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MGP005060

UniProt Annotations

Entry Information
Gene NameNADPH oxidase 3
Protein EntryNOX3_HUMAN
UniProt IDQ9HBY0
SpeciesHuman
Comments
Comment typeDescription
Developmental StageExpressed in fetal kidney and to a lower extent in liver, lung and spleen. {ECO:0000269|PubMed:10974555, ECO:0000269|PubMed:11376945}.
Enzyme RegulationActivated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)- dependent manner. Inhibited by diphenyleneiodonium chloride. {ECO:0000250, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103}.
FunctionNADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. {ECO:0000269|PubMed:15824103}.
SimilarityContains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule:PRU00716}.
SimilarityContains 1 ferric oxidoreductase domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitInteracts with and stabilizes CYBA/p22phox. {ECO:0000269|PubMed:15824103}.
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