MGP Database

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MGP005189

UniProt Annotations

Entry Information
Gene Nameinositol hexakisphosphate kinase 2
Protein EntryIP6K2_HUMAN
UniProt IDQ9UHH9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9UHH9-1; Sequence=Displayed; Name=2; IsoId=Q9UHH9-2; Sequence=VSP_010925, VSP_010928; Name=3; IsoId=Q9UHH9-3; Sequence=VSP_010926, VSP_010927; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=Q9UHH9-4; Sequence=VSP_042698, VSP_042699, VSP_042700; Name=5; IsoId=Q9UHH9-5; Sequence=VSP_042845, VSP_042699, VSP_042700; Name=6; IsoId=Q9UHH9-6; Sequence=VSP_045416, VSP_045417; Note=No experimental confirmation available.;
Catalytic ActivityATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic ActivityATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
FunctionConverts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. {ECO:0000269|PubMed:10574768}.
SimilarityBelongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11502751}.
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