MGP Database

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MGP005191

UniProt Annotations

Entry Information
Gene NameRh family, C glycoprotein
Protein EntryRHCG_HUMAN
UniProt IDQ9UBD6
SpeciesHuman
Comments
Comment typeDescription
Developmental StageSpecifically expressed in fetal kidney. {ECO:0000269|PubMed:10852913}.
FunctionFunctions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion. {ECO:0000269|PubMed:11062476, ECO:0000269|PubMed:14761968, ECO:0000269|PubMed:15929723, ECO:0000269|PubMed:16477434}.
PtmN-glycosylated. {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:20457942}.
SimilarityBelongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. {ECO:0000305}.
Subcellular LocationApical cell membrane {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:12204676}; Multi- pass membrane protein {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:12204676}. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.
SubunitHomotrimer. {ECO:0000269|PubMed:20457942}.
Tissue SpecificityExpressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney. {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:11062476, ECO:0000269|PubMed:12204676}.
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