#METABOLOMICS WORKBENCH sdasari_20150521_9198581_mwtab.txt DATATRACK_ID:246 STUDY_ID:ST000168 ANALYSIS_ID:AN000262 PROJECT_ID:PR000146 VERSION 1 CREATED_ON 2016-09-17 #PROJECT PR:PROJECT_TITLE Effect of Insulin Sensitizer Therapy on Amino Acids and Their Metabolites PR:PROJECT_SUMMARY Aims: Prior studies have reported that elevated concentrations of several PR:PROJECT_SUMMARY amino acids (AA), particularly branched chain (BCAA) and aromatic AA predict PR:PROJECT_SUMMARY onset of type 2 diabetes. We sought to test the hypothesis that circulating PR:PROJECT_SUMMARY aromatic AA and related AA metabolites decline in response to the use of PR:PROJECT_SUMMARY sensitizing agents in overweight/obese adults with impaired fasting glucose or PR:PROJECT_SUMMARY diabetes. Methods: We performed a secondary analysis of a randomized, PR:PROJECT_SUMMARY placebo, controlled study conducted in twenty five overweight/obese (BMI ~ 30 PR:PROJECT_SUMMARY adults with impaired fasting glucose or untreated diabetes. Participants were PR:PROJECT_SUMMARY to three months of pioglitazone (45 mg per day) plus metformin (1000 mg twice PR:PROJECT_SUMMARY day, N = 12 participants) or placebo (N = 13). We measured insulin sensitivity PR:PROJECT_SUMMARY the euglycemic-hyperinsulinemic clamp and fasting concentrations of AA and AA PR:PROJECT_SUMMARY using ultra-pressure liquid chromatography tandem mass spectrometry before and PR:PROJECT_SUMMARY the three-month intervention. Results: Insulin sensitizer therapy that PR:PROJECT_SUMMARY enhanced insulin sensitivity reduced 9 out of 33 AA and AA metabolites measured PR:PROJECT_SUMMARY to placebo treatment. Moreover, insulin sensitizer therapy significantly PR:PROJECT_SUMMARY three functionally clustered AA and metabolite pairs: i) PR:PROJECT_SUMMARY ii) citrulline/arginine, and iii) lysine/?-aminoadipic acid. Conclusions: PR:PROJECT_SUMMARY in plasma concentrations of several AA and AA metabolites in response to three PR:PROJECT_SUMMARY of insulin sensitizer therapy support the concept that reduced insulin PR:PROJECT_SUMMARY alters AA and AA metabolites. PR:INSTITUTE Mayo Clinic PR:DEPARTMENT Endocrinology PR:LABORATORY Sree Nair PR:LAST_NAME Nair PR:FIRST_NAME Sree PR:ADDRESS - PR:EMAIL Dasari.Surendra@mayo.edu PR:PHONE - #STUDY ST:STUDY_TITLE Effect of Insulin Sensitizer Therapy on Amino Acids and Their Metabolites ST:STUDY_TYPE drug + time course ST:STUDY_SUMMARY We previously reported the overall study design for the parent study [29]. The ST:STUDY_SUMMARY report primarily examines the effect of three months of insulin sensitizer ST:STUDY_SUMMARY on plasma concentrations of BCAA, AAA, and AA metabolites in overweight/obese ST:STUDY_SUMMARY with fasting hyperglycemia, defined as either impaired fasting glucose or ST:STUDY_SUMMARY diabetes [29]. Briefly, 25 drug naïve, Northern European American participants ST:STUDY_SUMMARY fasting blood glucose concentrations of 108?180 mg/dL were randomized to ST:STUDY_SUMMARY either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = ST:STUDY_SUMMARY or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect ST:STUDY_SUMMARY hepatic insulin sensitivity and pioglitazone based on its effect on peripheral ST:STUDY_SUMMARY sensitivity. Current use of hypoglycemic medications excluded participants from ST:STUDY_SUMMARY present study. ST:INSTITUTE Mayo Clinic ST:DEPARTMENT Endocrinology ST:LABORATORY Sree Nair ST:LAST_NAME Nair ST:FIRST_NAME Sree ST:ADDRESS - ST:EMAIL Dasari.Surendra@mayo.edu ST:PHONE - ST:NUM_GROUPS 2 ST:TOTAL_SUBJECTS 27 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:SPECIES_GROUP Human #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - ms1860-5 Drug:Metformin | Pre vs. Post:Post Study date=7/14/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1860-6 Drug:Metformin | Pre vs. Post:Post Study date=7/14/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1860-7 Drug:Metformin | Pre vs. Post:Post Study date=7/14/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1860-8 Drug:Metformin | Pre vs. Post:Post Study date=7/14/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1863-21 Drug:Metformin | Pre vs. Post:Post Study date=9/14/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1863-22 Drug:Metformin | Pre vs. Post:Post Study date=9/14/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1863-23 Drug:Metformin | Pre vs. Post:Post Study date=9/14/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1863-24 Drug:Metformin | Pre vs. Post:Post Study date=9/14/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1864-29 Drug:Metformin | Pre vs. Post:Post Study date=1/16/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1864-30 Drug:Metformin | Pre vs. Post:Post Study date=1/16/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1864-31 Drug:Metformin | Pre vs. Post:Post Study date=1/16/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1864-32 Drug:Metformin | Pre vs. Post:Post Study date=1/16/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1868-29 Drug:Metformin | Pre vs. Post:Post Study date=2/2/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1868-30 Drug:Metformin | Pre vs. Post:Post Study date=2/2/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1868-31 Drug:Metformin | Pre vs. Post:Post Study date=2/2/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1868-32 Drug:Metformin | Pre vs. Post:Post Study date=2/2/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1869-5 Drug:Metformin | Pre vs. Post:Post Study date=8/17/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1869-6 Drug:Metformin | Pre vs. Post:Post Study date=8/17/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1869-7 Drug:Metformin | Pre vs. Post:Post Study date=8/17/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1869-8 Drug:Metformin | Pre vs. Post:Post Study date=8/17/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1871-21 Drug:Metformin | Pre vs. Post:Post Study date=11/21/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1871-22 Drug:Metformin | Pre vs. Post:Post Study date=11/21/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1871-23 Drug:Metformin | Pre vs. Post:Post Study date=11/21/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1871-24 Drug:Metformin | Pre vs. Post:Post Study date=11/21/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1873-5 Drug:Metformin | Pre vs. Post:Post Study date=3/6/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1873-6 Drug:Metformin | Pre vs. Post:Post Study date=3/6/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1873-7 Drug:Metformin | Pre vs. Post:Post Study date=3/6/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1873-8 Drug:Metformin | Pre vs. Post:Post Study date=3/6/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1874-13 Drug:Metformin | Pre vs. Post:Post Study date=4/9/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1874-14 Drug:Metformin | Pre vs. Post:Post Study date=4/9/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1874-15 Drug:Metformin | Pre vs. Post:Post Study date=4/9/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1874-16 Drug:Metformin | Pre vs. Post:Post Study date=4/9/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1875-21 Drug:Metformin | Pre vs. Post:Post Study date=7/30/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1875-22 Drug:Metformin | Pre vs. Post:Post Study date=7/30/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1875-23 Drug:Metformin | Pre vs. Post:Post Study date=7/30/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1875-24 Drug:Metformin | Pre vs. Post:Post Study date=7/30/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1878-45 Drug:Metformin | Pre vs. Post:Post Study date=4/3/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1878-46 Drug:Metformin | Pre vs. Post:Post Study date=4/3/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1878-47 Drug:Metformin | Pre vs. Post:Post Study date=4/3/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1878-48 Drug:Metformin | Pre vs. Post:Post Study date=4/3/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-13 Drug:Metformin | Pre vs. Post:Post Study date=7/7/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-14 Drug:Metformin | Pre vs. Post:Post Study date=7/7/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-15 Drug:Metformin | Pre vs. Post:Post Study date=7/7/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-16 Drug:Metformin | Pre vs. Post:Post Study date=7/7/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-37 Drug:Metformin | Pre vs. Post:Post Study date=8/24/2010; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-38 Drug:Metformin | Pre vs. Post:Post Study date=8/24/2010; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-39 Drug:Metformin | Pre vs. Post:Post Study date=8/24/2010; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-40 Drug:Metformin | Pre vs. Post:Post Study date=8/24/2010; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1860-1 Drug:Metformin | Pre vs. Post:Pre Study date=4/20/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1860-2 Drug:Metformin | Pre vs. Post:Pre Study date=4/20/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1860-3 Drug:Metformin | Pre vs. Post:Pre Study date=4/20/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1860-4 Drug:Metformin | Pre vs. Post:Pre Study date=4/20/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1863-17 Drug:Metformin | Pre vs. Post:Pre Study date=6/23/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1863-18 Drug:Metformin | Pre vs. Post:Pre Study date=6/23/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1863-19 Drug:Metformin | Pre vs. Post:Pre Study date=6/23/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1863-20 Drug:Metformin | Pre vs. Post:Pre Study date=6/23/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1864-25 Drug:Metformin | Pre vs. Post:Pre Study date=10/17/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1864-26 Drug:Metformin | Pre vs. Post:Pre Study date=10/17/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1864-27 Drug:Metformin | Pre vs. Post:Pre Study date=10/17/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1864-28 Drug:Metformin | Pre vs. Post:Pre Study date=10/17/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1868-25 Drug:Metformin | Pre vs. Post:Pre Study date=11/10/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1868-26 Drug:Metformin | Pre vs. Post:Pre Study date=11/10/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1868-27 Drug:Metformin | Pre vs. Post:Pre Study date=11/10/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1868-28 Drug:Metformin | Pre vs. Post:Pre Study date=11/10/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1869-1 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1869-2 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1869-3 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1869-4 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1871-17 Drug:Metformin | Pre vs. Post:Pre Study date=8/30/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1871-18 Drug:Metformin | Pre vs. Post:Pre Study date=8/30/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1871-19 Drug:Metformin | Pre vs. Post:Pre Study date=8/30/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1871-20 Drug:Metformin | Pre vs. Post:Pre Study date=8/30/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1873-1 Drug:Metformin | Pre vs. Post:Pre Study date=12/13/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1873-2 Drug:Metformin | Pre vs. Post:Pre Study date=12/13/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1873-3 Drug:Metformin | Pre vs. Post:Pre Study date=12/13/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1873-4 Drug:Metformin | Pre vs. Post:Pre Study date=12/13/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1874-10 Drug:Metformin | Pre vs. Post:Pre Study date=1/17/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1874-11 Drug:Metformin | Pre vs. Post:Pre Study date=1/17/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1874-12 Drug:Metformin | Pre vs. Post:Pre Study date=1/17/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1874-9 Drug:Metformin | Pre vs. Post:Pre Study date=1/17/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1875-17 Drug:Metformin | Pre vs. Post:Pre Study date=5/8/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1875-18 Drug:Metformin | Pre vs. Post:Pre Study date=5/8/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1875-19 Drug:Metformin | Pre vs. Post:Pre Study date=5/8/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1875-20 Drug:Metformin | Pre vs. Post:Pre Study date=5/8/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1878-41 Drug:Metformin | Pre vs. Post:Pre Study date=1/9/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1878-42 Drug:Metformin | Pre vs. Post:Pre Study date=1/9/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1878-43 Drug:Metformin | Pre vs. Post:Pre Study date=1/9/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1878-44 Drug:Metformin | Pre vs. Post:Pre Study date=1/9/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-10 Drug:Metformin | Pre vs. Post:Pre Study date=4/21/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-11 Drug:Metformin | Pre vs. Post:Pre Study date=4/21/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-12 Drug:Metformin | Pre vs. Post:Pre Study date=4/21/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-33 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2010; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-34 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2010; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-35 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2010; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-36 Drug:Metformin | Pre vs. Post:Pre Study date=5/25/2010; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-9 Drug:Metformin | Pre vs. Post:Pre Study date=4/21/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1859-5 Drug:Placebo | Pre vs. Post:Post Study date=5/12/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1859-6 Drug:Placebo | Pre vs. Post:Post Study date=5/12/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1859-7 Drug:Placebo | Pre vs. Post:Post Study date=5/12/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1859-8 Drug:Placebo | Pre vs. Post:Post Study date=5/12/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1861-5 Drug:Placebo | Pre vs. Post:Post Study date=8/10/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1861-6 Drug:Placebo | Pre vs. Post:Post Study date=8/10/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1861-7 Drug:Placebo | Pre vs. Post:Post Study date=8/10/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1861-8 Drug:Placebo | Pre vs. Post:Post Study date=8/10/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1862-13 Drug:Placebo | Pre vs. Post:Post Study date=8/28/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1862-14 Drug:Placebo | Pre vs. Post:Post Study date=8/28/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1862-15 Drug:Placebo | Pre vs. Post:Post Study date=8/28/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1862-16 Drug:Placebo | Pre vs. Post:Post Study date=8/28/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1865-5 Drug:Placebo | Pre vs. Post:Post Study date=1/18/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1865-6 Drug:Placebo | Pre vs. Post:Post Study date=1/18/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1865-7 Drug:Placebo | Pre vs. Post:Post Study date=1/18/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1865-8 Drug:Placebo | Pre vs. Post:Post Study date=1/18/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1866-13 Drug:Placebo | Pre vs. Post:Post Study date=1/19/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1866-14 Drug:Placebo | Pre vs. Post:Post Study date=1/19/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1866-15 Drug:Placebo | Pre vs. Post:Post Study date=1/19/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1866-16 Drug:Placebo | Pre vs. Post:Post Study date=1/19/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1867-21 Drug:Placebo | Pre vs. Post:Post Study date=1/25/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1867-22 Drug:Placebo | Pre vs. Post:Post Study date=1/25/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1867-23 Drug:Placebo | Pre vs. Post:Post Study date=1/25/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1867-24 Drug:Placebo | Pre vs. Post:Post Study date=1/25/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1870-13 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1870-14 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1870-15 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1870-16 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1872-29 Drug:Placebo | Pre vs. Post:Post Study date=1/4/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1872-30 Drug:Placebo | Pre vs. Post:Post Study date=1/4/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1872-31 Drug:Placebo | Pre vs. Post:Post Study date=1/4/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1872-32 Drug:Placebo | Pre vs. Post:Post Study date=1/4/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1876-29 Drug:Placebo | Pre vs. Post:Post Study date=8/12/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1876-30 Drug:Placebo | Pre vs. Post:Post Study date=8/12/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1876-31 Drug:Placebo | Pre vs. Post:Post Study date=8/12/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1876-32 Drug:Placebo | Pre vs. Post:Post Study date=8/12/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1877-37 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1877-38 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1877-39 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1877-40 Drug:Placebo | Pre vs. Post:Post Study date=8/22/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-21 Drug:Placebo | Pre vs. Post:Post Study date=7/23/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-22 Drug:Placebo | Pre vs. Post:Post Study date=7/23/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-23 Drug:Placebo | Pre vs. Post:Post Study date=7/23/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-24 Drug:Placebo | Pre vs. Post:Post Study date=7/23/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-29 Drug:Placebo | Pre vs. Post:Post Study date=4/8/2010; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-30 Drug:Placebo | Pre vs. Post:Post Study date=4/8/2010; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-31 Drug:Placebo | Pre vs. Post:Post Study date=4/8/2010; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-32 Drug:Placebo | Pre vs. Post:Post Study date=4/8/2010; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-5 Drug:Placebo | Pre vs. Post:Post Study date=6/30/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-6 Drug:Placebo | Pre vs. Post:Post Study date=6/30/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-7 Drug:Placebo | Pre vs. Post:Post Study date=6/30/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-8 Drug:Placebo | Pre vs. Post:Post Study date=6/30/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1859-1 Drug:Placebo | Pre vs. Post:Pre Study date=2/17/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1859-2 Drug:Placebo | Pre vs. Post:Pre Study date=2/17/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1859-3 Drug:Placebo | Pre vs. Post:Pre Study date=2/17/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1859-4 Drug:Placebo | Pre vs. Post:Pre Study date=2/17/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1861-1 Drug:Placebo | Pre vs. Post:Pre Study date=5/17/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1861-2 Drug:Placebo | Pre vs. Post:Pre Study date=5/17/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1861-3 Drug:Placebo | Pre vs. Post:Pre Study date=5/17/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1861-4 Drug:Placebo | Pre vs. Post:Pre Study date=5/17/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1862-10 Drug:Placebo | Pre vs. Post:Pre Study date=6/5/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1862-11 Drug:Placebo | Pre vs. Post:Pre Study date=6/5/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1862-12 Drug:Placebo | Pre vs. Post:Pre Study date=6/5/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1862-9 Drug:Placebo | Pre vs. Post:Pre Study date=6/5/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1865-1 Drug:Placebo | Pre vs. Post:Pre Study date=10/25/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1865-2 Drug:Placebo | Pre vs. Post:Pre Study date=10/25/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1865-3 Drug:Placebo | Pre vs. Post:Pre Study date=10/25/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1865-4 Drug:Placebo | Pre vs. Post:Pre Study date=10/25/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1866-10 Drug:Placebo | Pre vs. Post:Pre Study date=10/27/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1866-11 Drug:Placebo | Pre vs. Post:Pre Study date=10/27/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1866-12 Drug:Placebo | Pre vs. Post:Pre Study date=10/27/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1866-9 Drug:Placebo | Pre vs. Post:Pre Study date=10/27/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1867-17 Drug:Placebo | Pre vs. Post:Pre Study date=11/2/2006; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1867-18 Drug:Placebo | Pre vs. Post:Pre Study date=11/2/2006; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1867-19 Drug:Placebo | Pre vs. Post:Pre Study date=11/2/2006; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1867-20 Drug:Placebo | Pre vs. Post:Pre Study date=11/2/2006; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1870-10 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1870-11 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1870-12 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1870-9 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1872-25 Drug:Placebo | Pre vs. Post:Pre Study date=10/12/2007; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1872-26 Drug:Placebo | Pre vs. Post:Pre Study date=10/12/2007; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1872-27 Drug:Placebo | Pre vs. Post:Pre Study date=10/12/2007; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1872-28 Drug:Placebo | Pre vs. Post:Pre Study date=10/12/2007; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1876-25 Drug:Placebo | Pre vs. Post:Pre Study date=5/18/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1876-26 Drug:Placebo | Pre vs. Post:Pre Study date=5/18/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1876-27 Drug:Placebo | Pre vs. Post:Pre Study date=5/18/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1876-28 Drug:Placebo | Pre vs. Post:Pre Study date=5/18/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms1877-33 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2008; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms1877-34 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2008; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms1877-35 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2008; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms1877-36 Drug:Placebo | Pre vs. Post:Pre Study date=5/30/2008; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-1 Drug:Placebo | Pre vs. Post:Pre Study date=4/7/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-17 Drug:Placebo | Pre vs. Post:Pre Study date=4/24/2009; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-18 Drug:Placebo | Pre vs. Post:Pre Study date=4/24/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-19 Drug:Placebo | Pre vs. Post:Pre Study date=4/24/2009; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-2 Drug:Placebo | Pre vs. Post:Pre Study date=4/7/2009; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-20 Drug:Placebo | Pre vs. Post:Pre Study date=4/24/2009; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-25 Drug:Placebo | Pre vs. Post:Pre Study date=1/14/2010; Samples time=6:30 SUBJECT_SAMPLE_FACTORS - ms2418-26 Drug:Placebo | Pre vs. Post:Pre Study date=1/14/2010; Samples time=7:00 SUBJECT_SAMPLE_FACTORS - ms2418-27 Drug:Placebo | Pre vs. Post:Pre Study date=1/14/2010; Samples time=14:00 SUBJECT_SAMPLE_FACTORS - ms2418-28 Drug:Placebo | Pre vs. Post:Pre Study date=1/14/2010; Samples time=15:00 SUBJECT_SAMPLE_FACTORS - ms2418-3 Drug:Placebo | Pre vs. Post:Pre Study date=4/7/2009; Samples time=13:00 SUBJECT_SAMPLE_FACTORS - ms2418-4 Drug:Placebo | Pre vs. Post:Pre Study date=4/7/2009; Samples time=14:00 #COLLECTION CO:COLLECTION_SUMMARY we drew arterialized-venous blood samples into plasma EDTA tubes, processed, CO:COLLECTION_SUMMARY stored them at ? 80?C until analysis. #TREATMENT TR:TREATMENT_SUMMARY Placebo|Metformin TR:TREATMENT_PROTOCOL_COMMENTS We previously reported the overall study design for the parent study [29]. The TR:TREATMENT_PROTOCOL_COMMENTS report primarily examines the effect of three months of insulin sensitizer TR:TREATMENT_PROTOCOL_COMMENTS on plasma concentrations of BCAA, AAA, and AA metabolites in overweight/obese TR:TREATMENT_PROTOCOL_COMMENTS with fasting hyperglycemia, defined as either impaired fasting glucose or TR:TREATMENT_PROTOCOL_COMMENTS diabetes [29]. Briefly, 25 drug naïve, Northern European American participants TR:TREATMENT_PROTOCOL_COMMENTS fasting blood glucose concentrations of 108?180 mg/dL were randomized to TR:TREATMENT_PROTOCOL_COMMENTS either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = TR:TREATMENT_PROTOCOL_COMMENTS or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect TR:TREATMENT_PROTOCOL_COMMENTS hepatic insulin sensitivity and pioglitazone based on its effect on peripheral TR:TREATMENT_PROTOCOL_COMMENTS sensitivity. Current use of hypoglycemic medications excluded participants from TR:TREATMENT_PROTOCOL_COMMENTS present study.|We previously reported the overall study design for the parent TR:TREATMENT_PROTOCOL_COMMENTS [29]. The current report primarily examines the effect of three months of TR:TREATMENT_PROTOCOL_COMMENTS sensitizer therapy on plasma concentrations of BCAA, AAA, and AA metabolites in TR:TREATMENT_PROTOCOL_COMMENTS adults with fasting hyperglycemia, defined as either impaired fasting glucose TR:TREATMENT_PROTOCOL_COMMENTS untreated diabetes [29]. Briefly, 25 drug naïve, Northern European American TR:TREATMENT_PROTOCOL_COMMENTS with fasting blood glucose concentrations of 108?180 mg/dL were randomized to TR:TREATMENT_PROTOCOL_COMMENTS either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = TR:TREATMENT_PROTOCOL_COMMENTS or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect TR:TREATMENT_PROTOCOL_COMMENTS hepatic insulin sensitivity and pioglitazone based on its effect on peripheral TR:TREATMENT_PROTOCOL_COMMENTS sensitivity. Current use of hypoglycemic medications excluded participants from TR:TREATMENT_PROTOCOL_COMMENTS present study. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Storage of plasma/serum samples at ? 80?C for qualitative and quantitative SP:SAMPLEPREP_SUMMARY using mass spectrometry are routinely done, demonstrating little to no evidence SP:SAMPLEPREP_SUMMARY storage related decay including samples stored greater than 20 years [7] and SP:SAMPLEPREP_SUMMARY The frozen samples were thawed on ice and spiked with C13-labeled internal SP:SAMPLEPREP_SUMMARY and processed for analysis as previously described [32]. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Amino acids in particular are relatively stable for several years, with the CH:CHROMATOGRAPHY_SUMMARY of their keto-acids (e.g., KIC), which we have not included in the present CH:CHROMATOGRAPHY_SUMMARY Subsequently, we separated the samples using an Acquity UPLC system, followed CH:CHROMATOGRAPHY_SUMMARY mass detection using a TSQ Ultra Quantum from Thermo Finnigan running in ESI CH:CHROMATOGRAPHY_SUMMARY mode as previously described [32]. We calculated the AA and AA metabolites CH:CHROMATOGRAPHY_SUMMARY using 10 point standard curves as previously described [32]. We handled the CH:CHROMATOGRAPHY_SUMMARY and post-intervention samples similarly and analyzed them in the same run. The CH:CHROMATOGRAPHY_SUMMARY of the UPLC/MS/MS method in the MCRMC is excellent (average CV ~ 9.5%) [32]. CH:CHROMATOGRAPHY_TYPE - CH:INSTRUMENT_NAME Waters Acquity CH:COLUMN_NAME - #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME Mayo Clinic Metabolomics Core #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Thermo Quantum Ultra MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS uM MS_METABOLITE_DATA_START Samples ms1860-5 ms1860-6 ms1860-7 ms1860-8 ms1863-21 ms1863-22 ms1863-23 ms1863-24 ms1864-29 ms1864-30 ms1864-31 ms1864-32 ms1868-29 ms1868-30 ms1868-31 ms1868-32 ms1869-5 ms1869-6 ms1869-7 ms1869-8 ms1871-21 ms1871-22 ms1871-23 ms1871-24 ms1873-5 ms1873-6 ms1873-7 ms1873-8 ms1874-13 ms1874-14 ms1874-15 ms1874-16 ms1875-21 ms1875-22 ms1875-23 ms1875-24 ms1878-45 ms1878-46 ms1878-47 ms1878-48 ms2418-13 ms2418-14 ms2418-15 ms2418-16 ms2418-37 ms2418-38 ms2418-39 ms2418-40 ms1860-1 ms1860-2 ms1860-3 ms1860-4 ms1863-17 ms1863-18 ms1863-19 ms1863-20 ms1864-25 ms1864-26 ms1864-27 ms1864-28 ms1868-25 ms1868-26 ms1868-27 ms1868-28 ms1869-1 ms1869-2 ms1869-3 ms1869-4 ms1871-17 ms1871-18 ms1871-19 ms1871-20 ms1873-1 ms1873-2 ms1873-3 ms1873-4 ms1874-10 ms1874-11 ms1874-12 ms1874-9 ms1875-17 ms1875-18 ms1875-19 ms1875-20 ms1878-41 ms1878-42 ms1878-43 ms1878-44 ms2418-10 ms2418-11 ms2418-12 ms2418-33 ms2418-34 ms2418-35 ms2418-36 ms2418-9 ms1859-5 ms1859-6 ms1859-7 ms1859-8 ms1861-5 ms1861-6 ms1861-7 ms1861-8 ms1862-13 ms1862-14 ms1862-15 ms1862-16 ms1865-5 ms1865-6 ms1865-7 ms1865-8 ms1866-13 ms1866-14 ms1866-15 ms1866-16 ms1867-21 ms1867-22 ms1867-23 ms1867-24 ms1870-13 ms1870-14 ms1870-15 ms1870-16 ms1872-29 ms1872-30 ms1872-31 ms1872-32 ms1876-29 ms1876-30 ms1876-31 ms1876-32 ms1877-37 ms1877-38 ms1877-39 ms1877-40 ms2418-21 ms2418-22 ms2418-23 ms2418-24 ms2418-29 ms2418-30 ms2418-31 ms2418-32 ms2418-5 ms2418-6 ms2418-7 ms2418-8 ms1859-1 ms1859-2 ms1859-3 ms1859-4 ms1861-1 ms1861-2 ms1861-3 ms1861-4 ms1862-10 ms1862-11 ms1862-12 ms1862-9 ms1865-1 ms1865-2 ms1865-3 ms1865-4 ms1866-10 ms1866-11 ms1866-12 ms1866-9 ms1867-17 ms1867-18 ms1867-19 ms1867-20 ms1870-10 ms1870-11 ms1870-12 ms1870-9 ms1872-25 ms1872-26 ms1872-27 ms1872-28 ms1876-25 ms1876-26 ms1876-27 ms1876-28 ms1877-33 ms1877-34 ms1877-35 ms1877-36 ms2418-1 ms2418-17 ms2418-18 ms2418-19 ms2418-2 ms2418-20 ms2418-25 ms2418-26 ms2418-27 ms2418-28 ms2418-3 ms2418-4 Factors Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Post Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Metformin | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Post Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre Drug:Placebo | Pre vs. Post:Pre 1-Methylhistidine^ 23.6730 23.5978 14.8756 12.7021 6.4071 6.2028 3.4613 3.6093 6.6445 6.2097 3.2714 3.4939 4.6182 4.8429 3.4464 3.0001 7.2407 7.7635 4.0991 3.1240 13.1173 11.7681 7.6175 7.4033 12.5284 10.8534 6.2332 5.7119 21.1957 19.7779 8.6139 8.0152 7.1531 6.7479 3.5961 3.4340 16.7319 9.7136 7.0273 5.6871 11.9052 11.1254 8.3982 6.7600 9.7454 9.0109 5.5172 4.6436 18.3397 14.9333 10.6906 11.0351 12.0147 9.7375 5.0800 5.6918 6.6866 5.4200 3.4158 2.8257 7.2082 5.9700 3.1995 2.4307 5.3868 6.4548 3.3079 3.2881 12.3676 10.3091 7.6119 7.6334 8.6545 12.1738 6.3269 5.5587 13.5174 7.9832 14.9864 14.2277 7.0906 5.5822 4.3846 3.8055 9.2585 9.6912 5.6920 5.3512 16.5466 9.6334 8.4208 9.7853 8.5125 5.7172 5.6949 17.4652 0.6251 0.6510 0.6319 0.4918 5.8991 5.9326 3.0340 2.9341 4.1541 3.7535 2.5741 2.6010 13.6828 15.3495 9.0831 8.5749 24.3219 22.7157 16.2378 13.9226 44.6638 42.0096 19.4499 23.8343 10.2429 14.9502 6.3198 5.3571 8.8476 9.2862 6.8900 5.7918 16.0132 15.5994 8.2201 6.5927 25.2794 26.0710 14.5302 10.6666 12.9693 12.8389 7.1432 6.3516 19.0673 19.7757 11.5020 8.8529 7.4259 6.2292 3.6870 3.2724 0.7491 0.7651 0.6005 0.5310 5.6377 5.2064 3.0619 2.8122 5.3030 2.7640 2.0591 4.5207 21.7918 20.7380 12.7298 10.9503 15.5458 6.1185 9.5365 16.2016 52.0841 41.8318 20.5242 18.3753 7.4173 4.4451 4.1840 7.5813 17.0830 19.7684 13.5636 11.2325 21.0193 20.3722 11.6883 9.7266 17.9421 16.8960 10.9867 8.9494 7.3347 10.9156 11.8043 6.5783 7.0032 5.6571 20.2502 18.8514 9.8602 9.7544 4.9122 4.1340 3-Methylhistidine^ 8.1559 8.4226 5.9734 4.7069 6.0280 6.1216 3.9148 3.3426 3.9390 3.3106 2.3845 2.3087 3.6465 3.9749 3.7969 3.0435 4.6544 4.0928 2.5766 2.3691 5.0470 4.8830 2.9501 3.1823 4.2777 3.9674 3.2015 3.1135 7.0327 6.9744 4.3611 4.4765 5.2630 5.3256 2.4416 2.6162 3.7695 3.7341 3.1003 3.0227 5.7653 5.2031 4.3954 3.7821 4.3327 4.2430 3.2176 2.9194 7.4242 6.8530 4.7708 4.9778 6.2859 5.9766 3.8404 3.8931 4.1178 3.4992 2.3076 2.1501 6.3197 4.4581 3.7453 3.2084 3.3168 3.9137 2.2456 2.5098 5.7012 4.6089 3.6789 3.4656 5.9245 6.0649 4.2015 3.0036 5.7177 3.5478 4.7039 7.3296 4.8152 4.5527 3.1242 3.0959 4.4745 4.0059 3.0004 2.8933 5.3755 3.5115 3.5583 4.2300 3.6536 3.4491 3.0847 5.8912 3.0726 3.6941 2.7177 2.4088 3.5152 3.6154 1.7586 1.7251 4.8116 4.6442 2.9613 3.0312 6.1525 6.4102 4.5453 4.5402 6.1908 6.0199 4.7772 4.5472 4.8620 4.3850 2.4300 3.6700 5.1423 8.2363 3.7702 3.2178 8.3900 9.2359 7.3232 5.7624 5.2724 4.4920 2.9274 2.7175 6.4677 6.2082 4.8645 3.9271 5.5470 5.7671 3.7583 3.9067 6.6718 6.4666 4.0575 4.1206 4.2186 4.5259 3.2040 3.1226 3.1223 2.7720 2.8110 2.4092 3.7835 3.0454 2.5348 2.2106 4.1199 3.0186 2.6961 4.4980 7.1960 5.7176 4.6899 4.2327 5.2389 2.7979 3.2214 5.1334 6.6115 4.9562 2.9813 3.1153 4.9086 4.0112 3.8423 4.9731 8.9972 9.1019 7.7733 7.2294 5.3544 5.1543 4.1050 2.9968 5.6962 6.0792 4.6441 3.7340 4.3263 4.6056 5.2032 3.4465 4.0539 3.2846 6.6688 6.6073 4.2682 4.1924 3.9823 3.5367 Alanine 388.3271 405.1923 262.4794 272.3235 475.3782 459.9615 279.0067 291.9535 416.4769 402.5200 316.2462 378.5059 518.5077 571.0407 438.8058 408.3593 391.8543 395.0218 438.4038 491.4553 234.3377 258.3147 294.5677 320.8952 304.5472 310.3507 456.8453 447.0851 412.0065 423.5888 340.3603 334.6627 498.2214 462.2693 331.0002 321.7843 389.6775 401.7237 273.4033 293.4023 233.7694 210.3199 279.2678 318.9650 398.6091 391.4076 344.8444 287.8193 385.8393 387.0882 277.7873 270.2923 542.7003 501.6917 316.9765 330.4692 385.6462 395.4690 301.5566 296.9176 600.5294 526.0786 375.5041 355.4390 374.3212 366.5194 331.9449 469.0173 191.4781 196.5493 289.5281 327.3859 264.6755 264.8314 255.6869 221.2991 332.5451 333.2403 341.9397 357.7189 300.5766 313.7916 295.9204 348.0458 476.1831 462.3415 256.2779 231.1900 206.5055 260.5877 271.0967 394.4749 406.8338 262.8009 272.9035 195.9433 458.9640 448.1970 349.2805 326.7803 382.2489 353.6743 287.2761 305.4068 329.0001 312.9562 325.9789 316.5693 422.1076 540.2181 252.2547 274.5098 404.4836 440.4567 283.7881 300.1746 351.5162 318.5026 253.1475 302.7593 333.2507 303.0340 299.5502 343.5408 331.7224 281.7042 253.1622 246.7941 405.5303 392.9377 361.7747 370.8874 370.1329 376.2240 397.9050 392.9971 369.7354 372.3573 241.0428 246.4794 263.1953 273.8174 272.8957 254.8761 311.0550 298.2201 246.4577 271.4498 471.4941 489.5166 364.9024 390.9964 384.9365 354.3173 281.3491 326.0218 298.1136 321.3161 306.1920 325.5867 653.6273 565.3795 429.9216 328.9569 400.9211 187.3339 261.2318 409.0163 393.4209 363.8269 246.0629 247.8184 340.2941 282.0360 295.8637 345.1297 256.5524 303.1005 213.6361 210.3211 323.4183 319.9390 322.7443 333.9358 406.0268 404.3134 369.4630 287.1311 296.2492 310.3336 320.2920 230.9163 289.2430 228.9146 319.5353 268.5769 284.2154 275.1335 270.7849 265.7982 allo-Isoleucine 1.2180 1.2481 1.6054 1.2711 2.7031 2.8693 2.9713 3.0511 2.4690 2.4696 1.8690 1.9829 3.2655 4.0214 4.2618 4.1794 2.3991 2.5975 1.9974 2.6338 1.3142 1.3761 1.7524 1.7186 1.1760 1.1701 0.8106 0.7645 1.8570 1.8824 1.9625 1.8230 1.8352 1.7600 1.0917 1.0249 1.1821 1.2337 1.2313 0.7351 1.6239 1.5762 1.1975 1.0538 1.6370 1.7206 1.5274 1.4401 1.2238 1.2418 1.3299 1.4269 3.5331 3.4991 3.5928 3.7776 2.0658 2.1869 1.9513 2.2664 3.5418 3.0496 3.3765 2.8900 1.9109 1.8816 1.9273 1.8875 1.0667 1.0143 1.0937 1.3785 0.8435 0.8939 1.0460 1.2851 1.6902 1.4507 1.7478 1.6468 1.2593 1.4119 0.7101 0.7250 1.2865 1.3238 1.1595 1.2206 1.5081 1.0883 1.1645 1.7447 1.7636 1.8615 1.8516 1.4891 2.8294 2.9081 2.5845 2.8228 1.6332 1.6086 1.3659 1.3939 2.0365 2.0431 1.5213 1.7472 0.6092 0.7970 0.9682 0.7998 1.9857 2.0925 2.4831 2.5972 1.4929 1.5589 1.0744 1.0056 2.7121 2.3029 2.7886 2.5336 1.0110 1.1086 1.1237 0.8885 3.3464 3.4170 3.3995 3.4944 1.9866 2.0267 1.2434 1.3988 1.7203 1.6932 1.7621 1.8811 1.6003 1.5933 1.1539 1.0772 1.6634 1.7251 1.4516 1.3252 2.9244 3.3693 3.4742 3.1656 1.8682 1.7043 1.6595 1.7463 1.4308 1.5167 1.2493 1.3777 0.8308 0.8090 1.1462 0.9111 1.5539 1.2457 1.6158 1.5835 1.8377 1.7255 1.4874 1.3725 2.7967 2.6697 2.9893 2.6331 0.9909 1.1651 1.6020 1.6147 2.5755 2.6604 2.9041 2.8741 1.6273 1.5610 1.3951 0.9631 1.3291 1.6453 1.7560 1.6533 1.3622 1.5887 1.2169 1.2907 0.9209 0.9226 1.1575 1.1736 alpha-Aminoadipic-acid 1.1219 1.0256 4.4882 4.2759 2.0872 2.3037 5.2015 5.6368 1.0819 0.9537 2.7877 3.2588 1.6544 1.6936 5.5304 5.7639 0.5997 0.6392 2.4911 2.8723 0.7602 0.8888 2.5327 2.7193 0.1964 0.2398 1.5135 1.5554 1.2500 1.1815 3.5002 3.9603 0.3449 0.2923 2.3985 2.4255 0.6369 0.6267 3.6494 4.0788 0.5879 0.5757 3.1231 3.3824 0.9934 0.9611 5.4784 6.0127 1.2138 1.0951 4.4413 4.0918 2.1604 2.2682 6.2836 6.8998 1.2908 1.3783 3.8242 3.6795 1.8376 1.5375 5.1645 4.7668 0.7293 0.6620 2.7476 3.0653 0.7052 0.5708 2.6878 2.3968 0.4148 0.4070 2.3312 2.1826 1.0111 3.3740 3.8616 1.1368 0.4754 0.4623 2.5706 2.6241 0.6731 0.6641 4.4594 3.9761 0.5477 2.7351 3.0311 1.3927 1.3564 5.9994 6.4088 0.6346 1.8446 1.9637 4.5864 4.5706 1.3777 1.4792 4.3426 5.1498 1.0676 0.9751 3.5263 3.6613 1.0972 1.3904 3.9326 3.8300 1.2055 1.4607 6.1348 6.1035 0.7434 0.7136 2.3291 2.5054 0.8871 0.4359 4.0188 4.3574 0.4760 0.4139 1.4349 1.5204 1.5828 1.4469 6.8176 8.6465 0.6314 0.6221 4.7161 4.4634 1.1116 1.2161 5.4940 5.2476 0.6916 0.6082 2.4512 2.7025 0.7509 0.7161 3.3818 3.4768 1.7259 1.7079 5.0182 5.0484 1.5245 1.3329 4.9551 4.7341 1.0700 3.7887 4.1004 1.0601 1.3387 1.0971 4.4552 4.0237 1.1136 4.2718 5.2542 1.2636 1.2454 1.0740 2.8889 3.3455 1.0632 4.6671 4.9216 1.0515 0.7752 0.6984 3.3491 3.3689 1.3097 1.1937 6.7952 7.5997 0.5123 0.6513 4.5938 3.8172 0.9349 1.0805 1.0846 5.2974 1.0705 5.7870 0.6174 0.5073 2.7813 2.6636 4.1583 4.5758 alpha-Amino-N-butyric-acid 24.2905 25.4129 19.2548 16.3312 28.0562 27.8917 33.3701 32.7390 27.2864 24.0950 21.0108 20.6891 42.6298 44.4507 43.2576 44.8889 38.4785 39.1657 32.8970 31.8864 25.1188 26.1053 19.6696 19.1004 42.3108 42.7173 45.9635 49.6974 32.0143 26.4527 28.9872 31.5241 27.3549 26.9757 27.1995 26.9448 26.7744 25.8324 20.5765 21.3277 21.6576 21.1483 9.4430 8.5990 27.3548 27.6995 24.8451 24.7172 23.9038 25.7115 20.2688 18.8711 32.1064 31.0497 33.7760 34.5944 21.4412 22.2620 20.4336 18.5078 41.3532 36.3012 34.4509 30.4526 30.4850 31.7185 33.2753 30.9905 19.9283 18.7294 17.0762 16.5210 34.0028 33.8203 32.1042 32.5000 30.4393 29.2616 30.0377 30.4240 28.4615 29.4336 24.2260 21.9153 24.7856 25.4371 20.2446 18.5398 14.7088 7.2196 6.9979 24.3400 25.1018 24.6061 21.7811 14.2314 22.1902 21.7980 19.5846 17.8162 24.1036 24.9579 17.0809 17.9670 28.8405 27.9159 24.4036 21.4161 18.4730 22.9135 18.7465 18.5097 19.3395 24.0472 17.6088 15.5060 29.5800 28.0077 18.4783 21.0347 29.5024 29.3806 30.4050 35.2223 31.2954 32.4435 25.0616 23.8601 31.7344 30.8542 24.5044 27.0824 25.7085 26.7045 20.7713 16.9616 19.4678 19.3184 12.6749 12.5789 20.9838 20.9578 10.7314 10.7780 21.1418 21.5611 15.5018 15.4875 24.7094 23.6276 21.9899 20.3124 27.2590 24.8436 21.2881 20.9205 32.9060 24.2061 26.0858 31.5083 29.6145 25.8891 26.7337 21.4815 22.7282 13.4435 17.6274 25.9268 28.0968 23.6684 17.3607 17.7821 23.6130 22.6320 24.6915 23.8287 22.9832 24.6335 21.5702 23.4976 33.6778 35.5942 26.3021 24.5830 23.1192 24.4588 17.3072 12.8021 19.9546 17.4687 18.2995 14.3049 19.9516 14.8782 17.4810 16.4749 11.1574 9.9929 12.7520 12.1660 Arginine 120.4296 137.6148 56.1155 53.0936 124.1811 91.6782 68.6847 47.3686 60.1672 64.6929 39.8493 65.2729 102.6794 94.1397 46.6867 82.9405 63.3047 76.6706 32.5914 30.8590 66.7225 68.9512 66.4989 37.5762 81.4909 77.3479 34.5520 30.5140 100.2178 102.5823 47.3872 45.0447 80.8112 73.4049 32.9232 31.0131 68.4086 58.5845 33.4094 26.7943 77.0221 78.8235 35.7160 35.0625 76.2408 86.3081 39.4945 35.7834 74.6523 72.8703 60.9960 62.5079 175.7405 118.0145 53.4591 117.2815 66.2823 92.2957 35.2758 37.2465 146.8992 117.0956 37.2029 29.1272 93.2927 98.2329 64.8056 209.0130 61.1390 55.4635 33.7694 35.1026 104.9519 127.0394 74.3014 49.0070 87.9654 44.6584 47.2733 94.0792 128.1285 95.1878 45.9003 52.0315 79.0459 69.8587 30.0250 27.1354 94.0739 32.2804 30.3947 85.9004 84.2246 51.9185 48.0472 91.9402 129.7467 132.9687 35.1708 39.6504 80.6075 82.2837 38.3053 39.5891 58.2743 75.1242 24.1848 26.2576 78.0766 83.1448 42.5390 50.3562 88.1920 95.9004 52.6372 49.7356 73.0338 74.5227 37.6090 42.2353 55.0162 57.3148 24.6007 23.0413 44.4197 55.0470 29.2331 26.3861 68.1141 64.6933 36.4196 30.7745 69.9913 74.4027 35.3840 29.3280 69.1181 65.0587 36.3390 37.0651 73.4011 71.8597 33.0423 31.6940 61.3143 66.3568 27.2673 25.1498 117.2576 90.4242 35.2579 45.9497 70.5390 70.1164 57.7022 54.4182 113.1726 42.6241 46.8622 91.8669 143.2452 94.4217 57.4873 44.5294 72.1751 30.1473 46.7868 81.3519 91.6680 80.4382 45.4111 44.3557 69.4861 36.8379 36.0868 66.2662 71.3319 86.8833 50.0406 50.9364 68.3304 70.7980 26.4939 27.9649 63.2023 69.5165 44.6292 33.6248 78.7599 49.4079 58.5138 33.1141 74.9575 33.9440 75.6122 79.2329 38.7884 36.6029 39.1403 28.6174 Asparagine 48.4600 54.1371 13.5205 11.8760 65.4788 64.4488 19.2326 18.5920 67.5689 74.8507 18.1006 16.8692 52.8090 58.5304 27.0437 17.8453 76.3710 85.6590 28.9398 25.3746 77.9659 77.6014 22.5413 21.8271 76.9501 84.2768 40.6718 34.6288 77.9434 68.2881 17.2608 14.4087 78.6432 69.2391 10.9894 11.6621 67.1573 63.4162 21.7746 19.5650 64.2178 62.9386 12.6894 14.1522 60.4161 62.0162 17.0876 15.8538 41.6314 43.1183 9.7318 9.6650 79.5984 66.3100 18.4508 19.4791 53.1106 58.8240 14.9385 15.0264 70.0607 67.9654 25.6001 19.8490 64.2078 71.1782 16.2423 57.2345 66.2213 53.0434 22.4988 22.3563 58.5524 64.8269 26.4823 24.6095 62.3352 15.2080 16.2059 64.2370 67.1824 63.2397 11.3275 17.4002 65.4149 62.5055 16.4004 14.7480 67.4646 13.8574 13.7022 51.8420 53.5919 18.3753 18.6536 67.6943 85.4938 81.3131 11.1721 11.3598 57.2407 56.6918 20.2376 21.0391 59.5639 61.0955 14.0927 16.5114 51.9110 54.3516 19.5086 18.2334 59.9541 55.4272 17.2199 16.9836 74.4002 72.4938 18.3809 21.9227 68.0221 69.6059 22.8888 21.4404 60.6849 65.8820 22.0480 17.4522 50.6721 51.6335 11.2532 11.4601 68.0009 61.8927 18.3975 15.8619 52.3865 48.1943 12.5061 12.3440 54.3556 54.9959 9.3839 9.4190 66.9786 70.7655 17.7320 16.6977 79.2804 72.6766 11.8957 10.9772 59.7502 52.4371 25.3173 21.5260 59.2085 18.7315 14.2223 62.4265 62.2750 63.0131 21.4439 20.6822 59.4102 10.4805 18.4974 58.3983 67.6838 60.6960 17.6698 16.4232 60.4099 19.9984 18.3129 65.4852 45.7813 54.0125 16.6694 13.9809 52.4683 54.4921 10.3554 9.7483 58.2705 60.2359 19.4040 16.3961 55.4680 37.6745 39.1479 15.6456 55.2377 17.8436 50.8498 47.6601 9.4908 9.5182 21.0101 17.8781 Aspartic Acid 1.9877 2.2071 1.6249 1.4131 2.7328 3.1893 1.4607 1.7945 2.1749 2.0889 1.0830 1.2849 3.3206 3.9259 1.7629 2.2224 1.5062 1.9453 0.8403 1.1831 1.9122 1.9144 1.2284 0.7414 1.3604 1.9546 1.2430 0.7967 1.9828 1.8815 1.2926 1.1708 1.1979 1.0185 0.6998 0.5476 1.6369 1.4028 0.9166 1.3312 1.7618 1.6685 0.6600 0.4082 2.0085 1.8012 1.4184 1.0893 1.9033 1.9493 2.2332 1.4030 3.6435 2.9286 1.7641 2.1542 1.8851 1.9359 1.3539 1.2132 3.5150 2.8117 1.5647 1.4432 1.8334 1.8177 2.6482 25.7764 1.4521 1.4934 1.1415 0.6043 2.2114 3.0552 1.1540 1.0047 3.9105 1.2872 1.9856 5.5069 1.7165 1.2113 0.8817 0.5587 1.7826 1.7660 1.0767 0.9486 1.4709 0.5750 0.5221 2.6793 2.5521 1.6841 1.5855 1.5898 3.1952 4.4220 1.4652 1.3867 2.4995 2.1186 1.3291 1.3023 2.5455 2.7366 1.1383 1.4362 2.9325 3.3352 1.9856 1.6843 2.7343 2.7671 1.5409 1.5876 2.0575 1.8122 1.9239 0.9470 2.1934 1.3073 1.2565 1.3717 1.2480 1.2133 0.9017 0.9667 1.8670 2.2030 0.9946 0.9989 2.1205 1.5016 1.2921 1.0401 1.5910 2.2457 1.3855 1.1157 2.3685 2.0118 0.9743 0.8820 1.7858 1.8953 0.8406 0.7489 3.2200 3.5188 1.3289 1.4996 2.0913 1.8720 1.3703 1.6020 2.4750 1.3106 1.2418 2.6291 2.7719 2.5505 1.9240 1.4393 2.3662 1.0519 1.4919 2.3732 2.2074 1.8731 2.0953 1.2067 2.0019 1.3143 1.1931 2.1243 1.6106 12.5455 1.3288 1.0534 1.7265 1.7663 0.8632 1.1559 1.8733 2.1488 2.7849 0.8877 2.0328 2.4145 1.5575 1.4037 2.3385 1.1884 1.8360 1.7172 0.7648 0.3067 1.1657 1.0818 beta-Alanine^ 2.5759 2.5772 2.0360 1.9716 2.9672 3.2677 2.6924 2.8533 2.5819 2.4767 2.1843 2.5693 1.6955 1.8611 1.6634 1.5632 2.1458 2.2664 1.8449 2.0352 1.9651 1.9050 2.0277 1.9699 1.5528 1.6664 1.3299 1.1862 2.0666 1.9465 1.6938 1.6475 1.3841 1.5309 1.0924 1.2902 2.0567 2.0484 2.4513 1.8738 3.0459 3.2957 2.8740 2.7522 4.4250 4.1001 4.5057 3.3226 2.6761 2.6391 2.2035 2.0639 3.0135 3.2635 2.9343 3.2161 2.2789 2.0634 2.2940 1.9908 2.2000 1.5745 1.6990 1.6274 2.7077 2.4993 1.7186 2.8477 1.6827 1.8109 1.8831 1.7195 1.6089 1.8584 1.0032 1.1498 2.2273 1.9597 2.3561 2.1446 1.4622 1.5936 1.3513 1.3776 2.3955 1.7940 1.7647 1.4147 3.2588 2.6754 2.7073 3.7830 4.4119 3.4875 3.3706 3.7381 2.2361 1.8827 2.1435 2.0498 2.4078 2.2387 1.7628 2.0051 1.9559 1.9091 1.6754 1.5852 2.2570 3.2523 1.9385 2.1367 2.1588 2.4232 2.0771 2.1940 2.7261 2.3732 1.8878 1.9030 2.1607 1.3807 2.0979 2.4423 2.4894 2.2138 1.8033 1.7786 4.2754 4.0159 3.3075 4.0272 2.9467 2.9775 2.8236 2.6409 3.2827 3.0620 2.7311 2.6072 3.3339 3.8405 3.6531 3.1586 3.1309 3.1331 3.3116 2.9695 1.9194 2.4377 2.2453 2.4347 1.9705 2.1996 1.7955 2.0996 1.9782 1.9230 1.8552 2.1103 3.5045 3.4353 2.8547 2.5650 1.9274 1.4440 1.6517 1.8609 2.9747 2.4899 1.9614 1.9850 2.2742 2.6614 2.6437 2.5471 2.1392 2.1157 2.0576 1.7857 3.6104 3.5779 3.2586 3.5740 2.7684 2.6675 2.7038 1.7727 2.5129 2.7781 2.6785 3.0522 3.4553 2.8995 3.2008 3.0011 2.8298 2.9570 3.3798 3.1315 beta-Aminoisobutyric-acid 0.7002 0.8031 0.8231 0.7310 0.5973 0.6661 0.6824 0.6916 1.5481 1.4013 1.5676 1.7594 0.8222 0.8390 1.3681 1.2344 0.7747 0.9727 0.7783 0.7998 0.6417 0.7079 0.6592 0.6441 1.6221 1.8151 1.2924 1.3117 0.7350 0.7267 0.6615 0.6935 0.6714 0.6257 0.6658 0.6332 1.8687 1.6485 1.6155 1.5623 1.0811 1.1124 0.5407 0.5298 0.7058 0.7153 0.8774 0.7959 0.8502 0.8764 0.9768 0.8289 0.5394 0.6235 0.7175 0.6163 1.2024 1.2513 1.4386 1.4708 0.8305 0.7652 1.1734 1.2187 0.5973 0.7296 0.5704 0.5003 0.7897 0.6715 0.6698 0.5690 1.3137 1.5745 1.0402 1.1256 0.9278 0.6738 0.8436 0.8620 0.8479 0.8477 0.6815 0.7162 1.6276 1.6456 1.6272 1.4454 1.0820 0.5224 0.5603 0.7516 0.7421 0.8985 0.9226 0.9902 1.7483 1.7268 1.6440 1.5425 1.5996 1.7038 1.2493 1.5486 1.5299 1.5726 1.4870 1.4701 0.7826 0.9715 0.9561 0.9274 1.0073 1.2153 1.4329 1.1681 1.0954 1.1378 0.8604 0.8098 0.6790 0.8411 0.9990 0.9747 0.8828 1.0034 1.0631 1.0193 0.7190 0.6508 0.8179 1.0336 0.6545 0.6105 0.5658 0.5319 0.6587 0.6558 0.7497 0.6260 0.9052 0.9192 0.6091 0.6394 0.8693 0.9256 0.9120 0.9772 1.8549 1.8661 2.0890 1.9769 1.5272 1.4183 1.4465 1.4462 1.8771 1.6492 1.6825 1.9442 1.1363 1.0802 1.1760 1.0699 0.8961 0.7627 0.9238 0.9331 0.8384 0.7296 0.5822 0.6608 0.5488 0.6759 0.6779 0.5002 0.6480 0.7343 0.9802 0.8534 1.0444 0.9969 1.0288 0.8902 0.6345 0.6097 0.6462 0.4606 0.6444 0.6973 0.6923 0.7739 0.8200 0.8131 0.3624 0.4166 0.3557 0.2851 0.7374 0.7112 Citrulline 38.9385 39.9785 40.2760 31.1088 25.1027 26.8332 27.6071 27.2396 26.0432 29.1625 25.4169 28.0554 26.0573 28.5208 28.8903 27.1635 12.1246 11.0921 8.5208 10.0764 22.8347 24.0394 22.6528 24.7145 39.6124 36.8717 19.4970 20.0936 47.9270 46.3718 35.4659 35.3634 21.8930 19.6168 19.1092 19.1816 24.0102 24.1391 29.0699 26.6005 43.1685 42.3272 33.0803 32.4366 20.8386 22.3609 11.7688 12.0798 35.8288 33.7292 35.5612 30.6742 31.7270 28.2574 26.3611 26.4550 23.0655 22.9937 24.1990 23.4373 31.3990 26.6478 30.2167 25.9382 24.5314 25.0403 23.8440 24.2820 21.5012 19.8961 23.1151 22.2849 48.2085 47.7769 36.5489 36.1114 40.2328 32.6512 33.0025 44.0166 35.3876 33.0266 28.1819 31.1951 33.3926 30.4178 28.1333 26.8419 43.0112 26.3887 27.3072 26.3929 23.3780 25.9162 25.8954 40.3136 40.9898 39.9500 28.2841 29.9641 25.1400 24.9657 20.9960 25.4390 14.5250 15.1502 19.1234 22.2913 25.8492 27.7073 29.6546 29.5685 33.5423 35.7997 33.7301 33.5018 33.6896 28.6433 23.3352 28.2210 20.1332 10.0450 12.8614 14.4699 14.7947 17.0956 17.0168 18.4360 31.0811 31.6168 28.8882 28.4570 36.2017 38.7736 28.1846 30.2255 31.2533 31.6282 29.3691 28.0216 31.6822 30.4792 26.7031 27.0446 26.8459 27.5263 26.8588 29.4254 32.9798 35.2567 34.9084 30.4426 26.4181 25.7434 24.3566 25.6309 22.0703 21.7819 21.0890 23.5938 34.0579 35.4817 38.7946 33.3489 29.0113 22.0282 30.2063 29.2826 42.4325 36.2413 30.8364 25.1141 34.5925 31.3159 29.6524 32.6597 26.7568 39.9434 25.9039 24.3638 28.7798 28.5449 29.8739 28.3966 28.6398 28.6107 30.1172 23.7099 34.4114 27.5541 25.0403 24.5573 35.6984 27.2575 39.8384 38.6448 30.3327 29.9769 32.0459 29.3347 Cystathionine 1 0.3387 0.3103 3.3771 2.8749 0.5278 0.5734 2.0037 2.2336 0.1928 0.1107 0.7430 0.7486 0.2409 0.2277 1.5881 1.7133 0.1376 0.1037 1.3534 1.4399 0.0381 0.0259 0.9154 0.9745 0.2696 0.2206 1.5460 1.6032 0.5547 0.6511 2.2951 2.1977 0.2378 0.2660 2.4279 2.1371 0.2722 0.2352 1.8599 1.7235 -0.0292 -0.0670 0.6778 0.6682 0.0811 0.0797 2.1994 2.0725 0.3980 0.4287 4.1505 3.7623 0.3829 0.3554 1.3023 1.5909 0.1178 0.1425 0.7718 0.8799 0.4365 0.2516 1.4640 1.3817 0.1401 0.1043 0.6678 0.8717 0.0894 0.0393 0.9575 0.8929 0.3314 0.2860 1.6066 1.6002 0.6238 2.4424 2.4247 0.5808 0.2423 0.2177 2.7335 2.7595 0.3535 0.3231 1.6820 1.5625 -0.0316 0.8985 1.0153 0.1303 0.0918 1.8666 2.0470 -0.0702 0.5623 0.5861 3.4239 3.2468 0.1922 0.1573 1.3086 1.2284 0.6611 0.5343 2.6414 2.8541 0.4601 0.4106 4.4661 4.3694 1.1207 1.2158 4.8244 4.7979 0.3433 0.2992 1.3548 1.5760 0.3718 0.2357 1.2040 1.3046 0.6899 0.6532 1.4039 1.4623 0.4190 0.3596 1.0335 1.1460 0.1326 0.1713 1.6641 1.6934 0.1723 0.1554 1.6457 1.4945 0.2481 0.1771 0.7188 0.7646 0.0526 0.0174 1.1727 1.3917 0.4744 0.4605 3.5136 2.8645 0.2534 0.1816 1.5652 1.4434 0.2462 2.1597 2.3030 0.2997 0.8028 0.6648 4.5229 4.1446 0.4226 1.3588 1.9921 0.5802 0.4458 0.2875 1.2736 1.3467 0.2982 1.0951 1.3452 0.3292 0.3300 0.2684 1.3726 1.4485 0.3306 0.3965 1.1425 1.4251 0.2861 0.2554 2.5489 2.0121 0.0725 0.0799 0.0332 1.3717 -0.0069 1.7180 0.0952 0.1407 0.9235 0.7427 0.8509 1.0395 Cystine 31.3022 28.6814 8.6656 6.6880 8.4954 9.3906 4.3622 4.3371 6.5143 7.9258 2.6905 2.1942 65.3966 85.8122 25.5495 49.1820 71.6151 67.0634 46.2114 46.9196 55.6151 62.1469 42.8649 25.9313 91.1359 95.7475 65.5722 69.2823 132.9878 124 71.7286 64.8417 98.7251 101.7197 59.0564 56.1300 135.6888 127.8083 86.2261 77.9243 62.9458 58.5508 26.6723 25.5550 90.6180 92.4624 48.2949 45.8319 37.9748 38.1208 13.4496 11.8240 8.7011 6.8557 3.7619 3.4058 9.7156 8.1945 2.8319 1.9696 77.6199 36.6913 21.0503 21.4050 44.4919 40.4425 4.8719 5.2703 76.1133 69.1479 41.0004 30.8461 93.8422 96.5464 57.2469 49.9103 104.9870 53.7602 59.0981 100.9920 106.8023 99.1415 59.8070 57.5795 123.8478 129.1602 77.6647 66.3128 59.8322 29.2341 27.5236 87.7006 87.8947 55.1558 57.4824 59.8922 56.2240 50.9277 18.4509 17.9670 28.3363 34.0458 12.5186 16.2640 12.0215 12.9373 4.0603 7.0034 10.5937 8.4729 3.5137 2.1165 102.5208 110.2108 48.0062 21.9077 114.0456 107.1658 63.1678 63.6465 81.5533 75.3994 62.4867 64.4261 115.6764 118.3957 79.3160 77.8562 95.3799 100.6963 46.8627 53.2551 116.4538 100.6468 55.6388 51.7568 87.4425 89.9110 49.1898 45.6635 71.0745 70.0505 33.7070 35.5275 75.2589 77.3162 31.2982 30.5536 54.0113 52.6485 22.3591 19.4530 39.4216 35.4968 17.6362 18.7178 31.2590 8.9647 9.5821 20.6440 7.6854 11.7686 4.9473 2.7960 60.7326 22.8684 30.2628 70.6021 106.4078 118.0431 53.9814 63.5169 109.2643 65.8880 76.1896 98.5244 121.3599 103.2924 63.2117 69.4112 108.0577 113.7256 47.1926 45.2022 93.2903 103.6171 52.1737 44.9558 77.1090 82.5452 81.9613 48.4009 80.0194 48.7129 77.5579 70.8800 41.5860 39.4434 37.5186 33.4060 Ethanolamine 5.8622 10.4552 5.6292 5.1732 5.7126 6.3860 5.4370 5.5322 7.0457 6.7916 6.2797 6.0664 6.0962 6.6488 8.6077 7.0524 3.6754 3.6593 3.3773 3.8410 6.3819 5.6408 5.0667 5.6774 3.3684 2.5682 3.4873 3.0326 4.9164 4.6536 4.4904 5.1427 3.3117 3.6348 3.2538 3.0817 4.3969 4.5460 4.2914 4.6885 6.0025 5.5619 5.5064 5.6825 6.8549 7.0975 6.8498 5.6576 5.9877 4.9053 4.9559 5.4699 6.9310 6.1648 5.7461 6.9185 8.4275 7.1437 6.5151 6.4201 8.7987 6.4103 8.3569 6.0631 5.3407 5.4538 6.4114 12.0831 3.8715 3.3126 4.4935 5.5262 3.7773 4.2321 4.6127 3.6063 4.7748 4.1115 5.1923 4.5663 4.2132 4.7405 3.6672 3.8165 6.4079 5.4120 4.4388 3.6057 6.1155 4.2812 4.3604 6.8107 7.2134 6.3597 6.5344 5.6860 7.8393 7.3292 6.0647 6.9260 7.2077 6.1755 5.0822 5.9113 4.4671 4.3758 4.0754 4.2236 5.8161 7.2416 4.3169 4.2667 5.2935 5.2293 5.1924 4.7401 5.5109 3.8733 4.7141 5.7674 3.6767 4.1900 3.7482 4.3838 4.1132 4.2537 4.7459 4.3447 8.1004 7.7549 8.5274 8.2116 6.2824 6.2502 5.6964 5.3450 6.5533 6.5695 5.4654 6.1554 5.5130 5.5302 5.9874 5.8709 5.5589 6.3640 5.6588 5.6638 7.6241 8.1707 6.3315 6.9068 6.3066 6.3725 6.1260 6.1163 5.2142 6.2237 4.9914 6.0500 7.3796 5.8851 5.9432 5.5176 4.5250 2.7242 4.5335 4.7670 8.7982 8.1536 7.5593 6.3758 4.7942 4.5835 4.3435 5.1178 5.0990 6.4283 6.1057 4.8676 7.1812 7.6704 7.5672 7.8630 5.1406 5.9127 6.6396 4.9692 6.3828 5.0112 5.5882 5.2901 6.1163 4.7966 6.6521 6.0810 6.1246 6.0017 6.2948 5.9111 Glutamic Acid 60.4915 59.1163 59.4235 50.9780 80.0556 79.2494 91.1385 79.0860 66.6188 71.4314 59.5632 64.7771 55.4645 69.2161 51.8647 50.6681 28.8145 26.1039 29.9605 21.3338 42.9649 39.6751 25.6342 19.7008 40.3334 39.4120 38.8013 36.0782 82.0811 70.7644 57.4567 54.3257 49.0276 41.4636 45.7450 31.6596 71.2956 60.3283 56.0921 48.3309 21.7422 22.0378 17.9555 15.1619 44.6203 47.9408 32.6934 38.0227 67.2124 65.8060 57.8352 51.3913 106.8023 103.2038 95.6668 80.5383 75.7315 70.5877 80.5796 73.9396 60.4415 68.3417 54.0500 54.2722 32.9577 31.9343 68.8909 317.8754 38.6751 36.9458 20.8784 16.9552 51.3588 55.8744 49.0187 44.0687 83.2915 68.0044 55.7854 76.5371 65.5362 47.2469 47.3857 34.1993 70.5821 85.1118 64.1896 60.1837 21.1809 19.7782 17.0189 60.7850 57.6479 57.2856 58.6605 26.7842 75.8678 87.1321 44.9943 45.4959 69.0691 73.7021 56.0937 58.9314 54.1477 50.6407 40.6038 46.5531 69.2304 60.7259 55.2842 50.2322 81.3301 83.7439 59.6029 51.8785 42.2361 40.3600 22.9618 17.7066 53.6222 46.9897 44.3116 36.6884 15.4078 22.0234 16.1457 18.3145 68.1266 68.0167 45.2934 49.2773 72.7961 77.6159 60.6203 59.6233 35.9027 40.3573 33.7514 27.6464 28.4688 26.9569 21.5499 19.4236 36.3286 32.7263 32.1812 24.8105 69.3822 60.8417 43.1320 42.9224 75.8268 72.1578 62.2797 60.0254 58.4402 49.5791 50.8234 61.6586 55.3465 67.7039 47.2771 46.7132 65.7723 47.9312 60.7331 71.4049 56.8582 56.6995 45.9458 38.9013 60.6135 48.8800 45.1864 58.2843 30.9985 38.9019 37.2010 33.7947 63.4616 70.7266 48.9957 58.8499 72.7138 74.2699 69.1345 54.6168 42.7833 40.0857 38.0208 38.7089 48.5607 40.9037 19.6667 22.3771 18.5552 20.1134 40.8459 38.7166 Glutamine 738.7826 780.4344 524.5831 515.4750 607.8422 639.8221 517.4375 465.2785 692.4522 645.2632 531.7805 581.0061 538.9980 548.9702 596.4492 507.8170 867.7721 811.2328 748.0366 722.8827 729.1547 652.1268 623.6648 728.0804 272.7290 253.9583 253.9638 225.7350 293.0244 258.1379 232.6346 243.4928 236.6531 225.5652 192.7165 183.2874 289.9983 253.8037 203.5396 217.9082 292.4356 287.9396 222.1018 231.9942 305.7954 319.1074 265.8332 235.2792 720.4089 697.7184 548.1943 626.1655 748.6675 643.5981 474.1610 498.7368 586.6436 575.1018 473.3311 471.7415 769.4487 675.4632 529.1876 441.3988 732.9672 748.1168 472.4015 184.7572 590.4064 525.4167 651.5850 635.4417 204.4080 251.3528 205.3990 190.0946 278.1866 201.0065 244.2220 248.9060 247.8111 242.3477 167.3370 173.2748 245.4925 229.7155 175.0320 171.9718 324.6481 247.3987 225.2533 272.8472 278.6117 214.8943 218.6082 318.3491 883.8160 779.4116 506.2642 575.8324 678.2170 742.6996 566.9605 574.8910 603.1466 621.0013 590.8365 654.8725 675.1924 732.3014 639.9879 623.5230 841.1248 788.9803 640.1145 602.6576 916.3174 842.8227 576.2404 750.2639 804.7406 1178.4040 896.5458 993.7390 904.7779 931.2161 715.4838 681.5574 258.5160 248.3048 239.9020 251.0630 269.2352 267.0389 245.0534 190.5996 293.8247 271.8159 210.3945 235.4409 319.4700 346.6670 232.3056 240.8604 266.1216 300.1327 242.8087 229.0379 908.7808 825.3766 644.1660 706.0932 687.1099 640.1199 583.4080 541.2873 663.3402 552.0856 539.5754 646.7704 888.4996 795.8494 761.4697 707.6543 782.1039 402.1564 579.3201 795.1058 1026.7410 858.7404 574.1621 574.8424 865.5184 794.1344 730.7973 910.0600 707.3568 779.8206 696.0399 627.7803 253.5812 250.9294 205.7230 208.2951 268.5447 254.4298 234.3346 179.0908 250.4968 223.2193 256.6631 210.9982 246.3741 212.2918 325.0594 308.4204 245.5096 234.0791 195.9084 199.4570 Glycine 234.8291 267.0690 115.6968 114.1817 151.3813 147.3766 84.8723 77.6660 156.9497 156.9847 95.6085 100.8824 125.5536 136.3931 83.2663 73.5021 153.1278 182.9398 122.3232 122.7248 131.2788 123.7567 76.4844 76.2511 223.6116 217.2710 142.2966 123.0095 215.3289 187.4441 103.0448 103.8151 418.7512 399.4272 182.6382 176.5875 230.6219 211.4889 131.2981 137.6164 168.7166 169.8532 82.1189 77.7351 162.1123 176.8532 84.5860 76.7585 237.7017 233.4077 126.9475 137.7160 164.0813 135.7346 61.2555 72.7337 121.0105 135.5566 74.3849 69.4806 170.7573 143.0624 71.8821 62.2757 135.4069 137.9304 82.6545 167.6284 116.9886 102.2186 71.7674 75.9209 147.9644 173.8250 80.2125 62.8788 177.6251 94.5634 113.6844 181.3866 345.6690 355.9900 160.9528 174.7322 212.8039 196.3680 90.6197 78.8538 208.2383 77.0090 70.1654 133.9368 126.4385 74.1013 64.3306 197.4862 273.3809 283.4265 104.7913 121.7041 143.3961 151.9365 72.6661 78.0990 235.2062 232.9529 124.5048 137.8913 177.1133 189.4689 97.5203 105.3443 133.6376 133.0613 77.3850 72.0926 265.4931 242.6020 133.4151 165.6739 129.2575 154.6655 80.5662 83.1977 208.8925 227.3897 157.1452 138.6967 137.0279 147.1710 89.6046 71.5739 178.2310 169.5755 93.0240 80.4235 133.5776 121.5473 54.4972 54.5921 125.3921 130.3952 62.8090 62.0233 174.6905 193.4108 92.6881 79.3348 267.2541 242.6378 119.8852 110.1347 137.2869 133.3184 91.2399 85.5112 229.0184 130.5206 122.5101 231.7266 191.6178 194.9484 136.1045 123.6970 143.4894 57.4203 81.4483 153.8717 224.8308 189.3823 119.2016 103.5329 128.6930 70.1823 68.5523 129.0040 163.9264 221.3411 112.5907 104.5688 151.7172 164.8772 75.7786 71.6945 146.4334 157.1879 97.6716 75.7179 150.4413 104.2224 108.2602 58.5369 154.0862 59.1560 125.6533 123.1834 67.0883 64.3582 75.0837 71.9836 Histidine 80.3534 81.3159 117.8890 111.6601 98.6759 88.6082 138.9604 139.0592 79.4989 79.1460 105.2890 117.4393 81.3431 78.0171 174.6482 162.9730 67.1294 71.3272 111.4881 113.7177 86.6613 81.2200 127.4862 128.2981 67.8855 69.3316 125.6756 109.4142 91.2138 82.8646 121.2244 140.3617 86.9823 83.9640 141.5425 134.5713 67.5814 64.8860 125.3410 110.1464 72.7143 68.2920 104.2349 109.6523 63.3446 70.0717 102.8555 99.9239 78.4212 68.1629 124.5538 127.0621 100.9157 85.8727 126.6820 134.0137 70.7870 69.2683 111.7730 112.3680 109.2527 103.7739 153.7515 122.1762 59.4316 68.1783 100.9521 162.1838 74.4419 61.2817 111.2932 134.6658 58.2167 66.8559 105.4811 94.6529 77.4677 126.4323 116.9424 83.7331 72.9601 88.4066 130.8686 129.0883 76.4650 63.7681 98.9547 95.2665 79.1892 135.3166 109.6137 58.2920 65.3332 112.6546 103.3504 72.9935 102.9199 96.1469 115.9703 138.7625 82.1275 75.0668 116.7693 117.9191 80.0984 81.8664 115.2737 153.7371 68.0805 79.4485 137.0621 119.7131 76.5614 79.8887 147.8125 133.4002 83.5488 81.8148 125.8555 139.1691 68.9607 78.4358 141.2400 129.1251 72.4185 86.4813 114.0055 109.0860 66.8716 70.3960 144.2191 131.2507 66.5606 103.5479 162.3141 124.4526 74.1299 73.7245 130.4932 126.8697 68.1428 72.7068 109.2584 104.9816 68.6481 67.2097 120.8191 110.8509 102.9970 94.4499 135.4546 125.8497 76.0813 72.1781 127.6225 136.1973 101.7470 130.1843 117.3351 79.1722 97.4741 82.0174 158.5802 148.1227 68.0893 86.2575 130.1993 78.5619 86.8283 80.6774 150.4851 116.7027 77.7817 129.8604 114.2655 67.7869 63.0984 82.2110 128.2685 118.5373 72.6604 71.0589 119.7644 135.5564 65.9767 68.8534 155.3325 121.5861 58.0366 58.5013 61.9726 100.3459 56.8974 112.6693 67.1481 66.6401 107.3081 98.0874 123.9439 101.9411 Hydroxylysine 2 0.4433 0.5266 0.5836 0.4892 0.6029 0.6979 0.6713 0.6442 0.4748 0.3735 0.4623 0.4552 0.6337 0.6051 0.7458 0.7768 0.1521 0.3220 0.2406 0.2519 0.3138 0.5685 0.3659 0.3676 0.5268 0.6183 0.4007 0.5145 0.4767 0.4103 0.3415 0.3711 0.6306 0.4521 0.3109 0.3579 0.4739 0.4250 0.5017 0.4644 0.3790 0.3828 0.4117 0.3893 0.5938 0.6138 0.6177 0.6574 0.4774 0.4766 0.5546 0.4708 0.6798 0.6366 0.6223 0.5866 0.3606 0.3881 0.4705 0.4135 0.7548 0.4652 0.6600 0.5321 0.2304 0.2467 0.2652 0.3280 0.2593 0.2504 0.2972 0.3050 0.3747 0.4095 0.4440 0.3768 0.3508 0.3182 0.3690 0.3566 0.2968 0.2843 0.3299 0.3203 0.3244 0.3798 0.4389 0.4008 0.3735 0.3703 0.3857 0.7055 0.6669 0.7509 0.7190 0.3425 0.4505 0.7857 0.4151 0.4396 -0.0572 0.4011 0.3568 0.4412 0.3555 0.3230 0.3533 0.4197 0.3816 0.4467 0.4337 0.4800 0.3626 0.4423 0.4274 0.3959 0.3829 0.3262 0.3002 0.3348 0.1742 -0.1605 0.2251 0.2180 0.7334 1.4038 0.7863 0.8021 0.4516 0.4145 0.3475 0.3720 0.9344 0.6111 0.3933 0.3496 0.6737 0.8076 0.5507 0.5159 0.7664 0.7328 0.6351 0.6990 0.5230 0.6880 0.5562 0.5828 0.4636 0.4242 0.4658 0.4389 0.5121 -0.0614 0.5348 0.4573 0.3827 0.3787 0.3996 0.3662 0.4464 0.4359 0.5062 0.4890 0.2811 0.1801 0.3055 0.3257 0.3866 0.3354 0.3013 0.3631 0.2159 0.2433 0.3134 0.1679 0.5858 0.7046 0.7234 0.7258 0.3782 0.3940 0.3269 0.3281 0.2875 0.2965 0.2976 0.2284 0.5442 0.4411 0.5145 0.5357 0.5639 0.4782 0.7014 0.7059 0.7090 0.7187 0.5187 0.6042 Hydroxyproline 9.4793 9.8757 6.4251 6.2972 7.8780 8.0776 5.7817 5.8434 11.1225 10.4736 8.0121 8.7174 9.6871 9.8500 9.2233 8.6527 7.9696 9.0999 7.0163 7.3754 6.7649 8.4258 6.1583 6.4641 8.9897 11.2628 6.4057 6.4720 7.8140 7.5394 5.0221 4.9235 8.1622 9.6911 5.5115 4.6339 8.4654 8.0531 7.2280 6.9912 7.3890 7.3073 5.8268 5.9344 7.0167 7.2904 6.0280 5.2155 9.6299 8.3742 5.5487 6.4420 8.3781 7.3968 4.9473 6.0322 9.2173 8.1652 7.4470 6.5412 9.4344 7.8661 7.1417 5.9380 6.9819 7.1603 6.3337 7.2437 7.1077 5.5862 5.6131 5.5203 6.2549 7.5385 5.1102 4.5765 5.5303 3.4632 4.5023 6.0703 6.1331 5.7708 4.2524 4.1807 8.9781 8.9105 6.0768 5.3740 6.9688 4.5243 4.0926 7.7215 7.5515 6.0536 5.8347 7.3238 6.5221 8.9232 4.9086 6.0893 6.1704 6.1900 3.8221 4.1447 7.0768 7.7036 5.8112 5.4267 7.8989 9.5055 6.5892 5.8202 7.5073 7.5338 6.6789 6.0866 7.2503 6.7745 5.0429 5.8423 6.0191 10.9628 6.0012 5.7895 9.4931 13.9733 8.3185 7.3036 9.7573 9.0694 7.8382 7.4559 14.1716 12.2889 7.6955 6.0402 8.1343 9.9139 5.7691 5.9764 8.6285 9.1360 5.5941 5.2912 9.0117 9.1861 6.1417 5.7637 6.2883 5.8733 4.9605 5.4212 6.9766 6.1594 4.6981 4.5094 6.4225 5.4234 4.6822 6.8567 9.9622 8.1911 7.2661 6.1587 7.1692 3.9194 5.3889 7.1371 8.0943 6.6178 4.8840 4.2620 5.7693 5.8018 5.1520 5.8699 6.0757 6.7763 6.9068 5.7857 9.6023 9.8836 6.3998 6.4676 7.4964 7.0849 5.3073 4.6921 7.6268 5.5245 6.1095 4.2314 6.8410 4.2594 8.6353 8.2009 5.5013 5.5144 5.7398 5.3489 Isoleucine 60.0847 69.6007 203.4649 195.0545 119.6036 123.4885 280.6530 268.5404 86.3404 84.7596 194.9315 204.6012 98.6251 113.4749 353.9341 355.2067 81.2400 82.2659 189.6298 179.4175 71.6602 72.3962 146.1592 154.3316 66.5658 64.1365 158.7497 153.2332 109.3178 110.9213 223.2297 240.7868 61.8063 52.3134 183.3031 169.2059 56.4001 52.7973 195.0149 169.1128 76.1117 70.1549 194.2127 189.9797 79.8835 82.4295 224.1792 236.9600 59.3489 54.9182 204.0911 195.4792 131.5716 108.7278 296.0907 298.7839 73.2715 76.9944 219.0167 219.4633 111.9470 93.2910 283.8999 261.1276 66.4215 60.4579 191.5473 217.8753 63.5699 53.6710 138.1749 137.9077 55.0049 56.5192 186.8543 183.5747 91.3914 225.9174 159.8115 89.4948 55.5407 50.1413 176.0313 165.9933 58.3024 52.8818 214.7381 215.4711 71.0824 208.9065 202.3575 86.4246 84.3533 267.5506 262.2676 70.5792 135.5276 130.5695 234.5025 229.7602 67.1575 63.4832 172.4240 185.3963 94.2805 89.6371 194.7842 240.7156 47.8323 56.0379 159.6729 145.5751 106.1545 110.3757 376.3878 339.6710 79.4626 76.0499 150.5225 162.4461 97.9040 81.0118 235.4448 235.0269 58.2667 59.5570 139.0470 142.3277 110.9900 100.1088 315.6901 329.6631 70.3555 136.9425 206.2193 207.2526 81.5086 73.0173 248.2553 223.8035 80.7727 76.0158 178.4216 182.8816 76.9318 74.2509 186.4068 197.4961 119.3992 131.4948 259.6415 252.7778 72.8372 65.4660 205.2012 202.2926 100.4276 182.6611 185.8781 66.3210 56.5537 51.3763 177.7091 153.5271 90.1226 227.1551 321.1843 93.3626 92.4986 79.8684 209.1393 169.3687 87.8946 266.0289 265.6495 87.9902 50.9299 62.8975 183.4605 189.5012 98.9542 94.8964 288.3132 296.3808 62.3597 61.6096 205.7859 160.7852 65.8235 58.4965 58.6413 219.6846 67.1634 233.0437 58.9584 58.0670 158.6976 153.0082 189.7527 177.0029 Leucine 123.8897 134.2866 349.2927 332.6039 220.9087 226.2779 487.4921 474.1063 167.3140 167.7289 333.1084 360.7164 195.7127 227.3882 606.9275 615.1780 150.5699 159.3960 319.4662 303.2866 132.0515 128.5501 263.4034 272.5105 133.4465 131.4503 263.9267 257.4128 197.4856 209.9519 394.9515 430.0377 125.6752 111.6377 333.1591 300.3284 120.4427 112.8255 350.2780 302.9318 149.8586 139.9305 328.8435 323.9335 165.6456 170.6592 397.5086 414.4889 110.5797 112.2817 342.3141 341.4658 237.0332 205.3540 508.5817 500.2329 151.7018 146.6818 390.2324 372.8561 233.1682 189.8576 501.6920 447.4616 130.5106 120.7502 339.2829 406.6698 123.3038 109.5023 242.3175 253.6451 115.5237 115.5452 322.6025 314.3791 166.1347 401.8639 281.0118 171.4331 120.8582 115.1788 310.1671 298.2212 123.9337 113.1747 381.3563 392.2457 141.3270 350.0628 342.4612 170.0307 167.1502 474.7261 459.9323 141.3637 245.2510 235.3838 385.5998 378.1215 141.7584 132.7296 314.4044 326.8508 178.2294 170.1747 323.8372 390.9366 96.0164 113.8496 285.7167 270.4426 204.7023 222.2166 700.4312 623.4669 174.5574 165.3332 286.6324 314.5889 176.8540 148.0825 390.0139 415.3797 111.6823 110.3359 226.9281 234.3873 214.5763 208.0670 551.7770 603.4218 147.0239 252.2053 371.2702 367.8976 165.1050 150.3583 451.7910 408.3857 148.7836 137.0598 282.1022 303.9446 164.6719 159.4788 323.6958 350.9622 222.4023 235.3849 429.7391 411.7490 154.5208 144.8049 369.9366 362.9357 180.8951 322.9176 322.3494 132.7436 118.2127 114.6487 337.9272 276.5347 181.8977 400.9009 549.7691 189.3848 201.4771 177.1287 376.6524 325.5704 166.2316 451.7161 443.7178 169.1234 107.9215 123.2813 330.8959 328.2703 202.7849 194.4402 555.9451 546.9917 124.3369 122.5793 383.8065 294.8646 152.0638 136.8111 142.2287 417.7800 155.7623 431.9155 121.5973 116.4929 270.6220 272.8738 335.5187 324.2114 Lysine 221.8450 224.6029 305.1015 331.5700 396.6843 346.9313 512.5587 489.7530 209.8545 188.1856 407.5507 408.7339 189.9657 231.9177 422.3169 343.8100 185.3848 207.1634 366.9664 447.3349 210.8684 227.4803 475.4089 384.2236 194.8690 206.5440 397.3399 432.1566 291.0032 298.1439 405.9449 414.4954 270.3565 269.1795 455.8237 478.7871 166.5192 182.1282 455.8349 417.7043 166.4488 168.4764 294.8441 336.8168 243.4545 251.1824 410.3008 473.3889 180.9346 175.0166 386.6687 329.1529 434.7748 378.0856 531.0259 509.0591 191.7452 210.3066 368.8581 372.3175 228.9066 227.9372 305.4871 350.5682 199.4954 180.0008 323.4513 460.4222 193.3297 181.5380 412.3625 353.1383 213.9939 219.2046 424.0858 389.9743 267.8458 433.4967 399.3563 282.4928 270.4131 249.4471 445.5880 496.6321 197.5994 179.7946 363.0690 322.7745 157.1291 281.8706 294.5764 242.4318 226.4707 426.2716 422.2576 142.1101 213.9450 207.4696 282.2608 248.4811 218.7918 207.6227 439.2468 443.7181 197.0869 197.7113 396.2551 439.9473 162.5689 210.3865 279.7221 303.5683 164.4281 169.9986 359.3376 299.3341 202.1514 215.7199 339.7674 327.2160 202.4801 195.1526 399.4639 544.4161 156.8949 143.8579 299.7920 327.2912 269.7966 265.1618 491.8874 694.1711 190.5129 267.5479 475.5617 457.1678 212.7663 210.7770 360.0567 233.9232 151.6867 129.3413 256.0047 276.3657 147.3008 171.7118 286.3547 319.6418 211.6700 202.0981 272.5223 317.9764 194.9772 211.8532 360.7990 406.7571 259.2712 462.0882 463.5264 206.0164 228.6398 193.8222 350.7293 334.0572 176.7979 285.0724 380.2630 170.7803 233.8587 224.0197 325.3029 298.1657 210.8594 426.8408 482.6774 208.2118 194.7876 224.4043 425.6039 406.1156 231.6852 296.3480 491.8965 509.7659 192.0245 214.6824 515.9933 378.1207 128.9717 168.5328 151.0444 281.5898 174.8300 337.3882 131.4804 135.2412 272.7647 269.5750 276.8255 326.6796 Methionine 19.1004 20.0169 440.1166 491.0452 38.7802 33.0439 647.1982 706.2938 26.2764 25.0202 730.7190 823.9361 23.5024 27.7867 779.4344 791.7134 25.2897 22.3652 543.5069 638.9268 22.0145 22.4545 611.3692 609.2917 32.1736 32.1192 512.7893 561.6339 31.5655 30.1386 535.6774 593.7108 23.0171 21.8250 553.1360 551.3413 19.1185 18.9551 642.7613 618.7783 18.4895 16.1189 636.2458 737.8290 21.0148 23.2295 732.2789 806.6491 15.9863 16.3072 512.3631 505.1632 40.7889 29.7929 649.9667 698.1619 22.7663 24.8264 694.5394 785.9307 33.5448 26.3507 631.7357 692.1536 23.0756 22.7769 602.4850 729.8672 19.0658 17.6332 559.1999 554.8808 29.3959 29.3901 582.3423 612.2923 24.6356 572.1792 627.8237 25.3951 21.2219 19.2152 544.2994 572.2149 20.0142 17.2126 599.9696 594.1447 18.1073 552.4820 573.3222 20.2792 19.9127 662.4284 732.6291 16.7856 30.1530 30.4040 504.9831 504.1931 20.4096 20.0044 658.1123 679.7766 21.5769 19.5752 621.4943 771.8118 16.4392 19.6725 411.2084 439.0150 21.1463 21.7480 810.6942 776.6603 27.0985 28.1674 616.1520 744.1632 27.6922 21.0656 733.1442 853.2109 21.4181 21.0912 528.5161 579.0665 25.9815 27.8809 837.3788 922.7856 17.8893 100.7107 666.9782 729.4395 19.0660 16.8125 648.1507 564.1056 17.6880 16.0522 587.8876 688.7990 21.2825 22.0124 637.5934 677.6560 26.4468 28.0446 622.1848 713.7010 20.8007 20.9494 600.1634 771.0152 59.6232 639.7760 700.2198 19.2139 27.3865 21.5926 519.3120 512.7794 18.8928 555.4719 822.5885 20.9073 32.5409 27.0779 705.5093 692.0846 22.7354 717.8905 837.2880 22.7878 18.9846 19.2636 690.7853 743.7897 26.8290 29.3495 848.6222 919.6644 17.4296 20.2742 723.7362 640.0103 17.7911 15.6337 15.2892 518.7224 19.4748 627.1216 15.4567 14.2753 588.8150 621.9447 502.3669 611.4595 Ornithine 63.5647 62.4892 37.7886 32.8836 76.5242 88.8660 31.3035 34.8142 77.3744 69.8811 29.0599 28.1528 40.9265 48.7400 17.4677 14.9434 41.9650 45.4598 20.2928 16.2930 50.2376 44.3760 17.4335 15.8337 54.3738 66.5580 22.6108 22.0474 81.1851 73.0647 32.5907 32.7419 70.7007 70.7274 29.6500 28.9748 47.8334 43.9567 17.1576 17.6035 58.8017 54.6725 21.3971 19.8526 64.1730 60.1921 23.9803 22.0533 61.7773 57.5669 40.6821 36.3956 61.9649 62.1548 30.0793 26.5498 57.6594 51.8615 25.7960 24.2438 45.6956 41.2712 18.4484 16.1761 44.9460 40.9413 25.3508 33.4970 37.8886 35.5233 19.2247 16.7729 58.7235 63.4444 28.0707 27.9807 77.3742 30.7485 32.9623 77.7948 79.8759 74.0841 42.1050 44.9775 49.2224 44.6335 19.0474 16.7082 55.7459 20.9326 20.4769 56.6022 50.6535 26.3682 23.3915 59.0162 77.6857 88.1631 22.8280 20.9319 53.1143 55.5008 23.8097 23.7948 52.9804 53.1793 17.7150 17.3123 72.1389 80.3329 34.5120 31.7254 62.4417 71.4699 29.8368 25.3238 47.7027 50.7359 21.5873 19.9512 61.7901 56.9181 20.7055 20.5180 59.7335 59.7046 23.5547 18.6249 54.2281 52.3139 15.4253 14.7120 64.0471 49.7972 22.5038 20.7908 70.5229 70.8343 30.7213 23.1590 57.5146 50.5956 17.6603 15.7587 66.5978 65.5224 16.1780 14.2194 79.6701 71.0386 25.5383 20.3022 56.0855 51.1228 22.8310 20.6524 45.8360 22.2014 19.4346 44.4051 94.6701 78.9939 45.3832 34.2381 57.8888 20.5582 26.1643 67.3841 51.3750 39.1731 22.0168 20.3299 64.0390 30.1337 28.7422 66.8023 55.0668 59.6079 29.6604 30.8554 46.8485 43.7565 14.8423 13.1948 51.4746 50.9755 28.8455 20.6970 50.5157 64.2073 59.1678 28.7550 56.6403 28.8434 54.5929 50.3483 20.7054 19.2220 20.9453 17.4418 Phenylalanine 57.7488 60.1327 207.4830 194.9596 76.1450 77.8188 211.9637 219.0330 56.9156 54.4349 187.8438 203.9520 59.6870 65.8311 216.1354 210.6278 44.3692 46.8967 172.0841 174.5300 49.6558 47.1441 161.6646 166.0676 55.1859 59.2936 177.3541 177.7338 69.6882 71.7255 183.2296 198.9457 47.5304 44.4549 178.0923 173.8458 49.3828 49.8051 203.9681 189.8512 53.0093 50.2217 216.0572 220.5904 60.9548 62.2284 217.4168 211.7784 51.3056 51.9717 204.5942 205.2958 83.3982 71.8451 201.1845 200.4431 54.9527 53.6867 190.3026 181.6839 74.0723 60.0760 200.4465 196.8201 50.4951 48.9674 177.0547 206.0590 45.9002 42.2721 148.7588 150.0321 61.5201 62.6366 187.6542 191.3166 59.1665 189.7408 163.7483 63.7022 50.7496 46.3893 189.3555 185.2431 56.0682 49.4788 182.5700 181.5876 50.7204 198.4954 203.6189 64.6254 63.5960 214.6351 212.7803 47.5879 78.4712 76.7536 186.0591 187.9858 61.3701 64.7046 196.0024 211.4757 48.8100 48.0503 170.1812 188.9721 46.4577 53.2737 151.7475 158.2565 60.5581 66.8854 227.4808 223.5481 58.3898 59.2489 170.1857 186.1751 57.7547 47.4755 180.4271 194.1674 50.6324 48.9940 195.9307 207.4251 66.8396 66.6871 232.1241 231.1076 59.7589 77.0909 221.7577 229.5972 60.2932 57.4106 232.7184 210.1820 57.8478 58.3541 222.7333 234.2576 57.9465 56.2156 197.2163 210.2145 68.6086 71.8550 219.1441 213.4702 64.9498 61.8985 204.1110 223.6487 39.4421 189.2824 197.7159 51.6481 59.2533 56.1578 185.4756 162.9436 56.0134 175.4015 222.2682 59.3657 71.4575 63.1612 182.4022 163.8961 58.1642 209.0012 197.0040 63.1579 52.9113 61.4215 216.5318 203.5897 66.9103 65.0594 225.3766 237.6202 57.9532 57.6849 231.5481 200.1575 60.0225 63.1409 66.3167 210.8485 61.9847 221.2457 57.4007 52.6950 201.6029 202.1319 202.7536 198.4621 Phosphoethanolamine 0.5295 0.5555 0.1718 0.1288 0.2538 0.1120 0.0928 0.0807 0.0799 0.0849 0.0786 0.1424 0.3830 0.1377 0.0321 0.0394 0.7290 1.0638 0.3181 0.7348 0.4284 0.2539 0.1892 0.1510 0.1737 -0.1262 -0.0584 -0.3364 0.4268 0.4880 0.5466 0.2001 0.4959 0.3499 0.2460 0.4861 0.2737 0.1335 0.1055 0.8410 0.3047 0.6400 0.3205 0.3423 0.9894 0.4480 0.6793 0.2275 0.4332 0.4060 0.2271 0.2135 0.2497 0.1670 0.0826 0.2196 0.0884 0.0746 0.0831 0.1925 0.1519 0.1025 0.0454 0.4713 0.2688 -0.2736 0.4263 0.3339 0.4934 -0.0776 -0.1897 -0.1120 -0.3199 -0.4443 0.6277 0.3581 0.6340 0.4381 0.7022 0.4034 0.5590 0.2757 0.3208 0.0131 0.2559 -0.1695 0.3701 0.1775 0.0635 0.4658 0.5871 0.4493 0.4595 0.4969 0.8368 0.7386 0.2638 0.3364 0.3631 0.3395 0.1880 0.1414 0.2401 0.3663 0.1343 0.0956 -0.2154 -0.2139 -0.2329 -0.2315 1.0792 0.5668 0.5408 0.6239 0.7247 0.8400 0.9948 0.6756 0.5706 -0.2588 0.2449 0.4806 0.5724 0.5924 0.6564 0.6479 0.4756 0.0586 0.2757 0.2345 0.3581 0.3280 0.3018 -0.0797 0.6133 0.5143 0.0114 -0.0747 0.4124 0.2490 0.5401 0.3018 1.9128 2.0502 2.2091 1.3857 0.4805 0.4857 0.1859 0.3015 0.2958 0.4325 0.3478 0.3568 0.2621 0.1388 0.1278 0.1454 0.0643 -0.2329 -0.2198 -0.2312 0.8051 0.1558 0.4328 0.8667 1.2541 0.6305 0.5252 0.3750 0.4816 0.2943 0.2616 0.7205 0.5157 0.5182 0.6116 0.2904 0.0897 0.0945 -0.1853 0.3240 0.1116 0.2656 0.1908 -0.1160 1.7345 0.1628 0.1236 0.4253 2.0992 0.0444 0.4112 0.2613 0.2338 0.3911 2.0823 2.2197 Proline 201.4163 215.3644 83.3646 71.1490 187.3013 197.7604 78.4199 74.3602 338.0645 305.7935 140.9754 153.0415 241.7940 255.1800 116.1953 112.7123 242.4083 254.4565 113.8130 118.9674 136.3493 137.6923 66.0797 59.9549 205.8767 216.0101 126.3873 120.5211 295.9208 270.8491 107.8539 95.7068 278.8430 260.3560 94.7703 91.5125 162.1296 146.1660 54.2868 53.2583 138.7032 128.7361 51.0394 52.8086 207.0135 208.1172 83.4762 81.5023 193.0892 209.5880 84.9024 79.3335 235.1881 198.0033 87.2213 84.5848 281.5673 280.7269 130.0699 132.3854 288.3773 232.1174 103.1934 88.4052 205.5852 199.8370 94.3708 144.8039 121.9137 117.8922 67.6268 63.9416 186.9140 189.8877 91.7597 90.0339 235.8036 94.9972 98.9489 239.9988 215.8668 203.9842 78.5670 88.1563 159.3252 139.8779 51.6486 48.0509 130.4474 47.9299 49.9405 193.8828 183.9166 87.3579 82.9380 128.4694 320.0920 322.0309 115.1964 109.0835 139.2867 152.0496 59.4879 63.1321 325.5795 322.4739 143.1507 131.2625 252.3068 281.9334 97.5974 92.1917 164.8641 205.9868 87.8341 85.6606 194.0966 194.6683 76.4606 76.8900 204.8951 162.6190 92.4032 94.4232 213.0467 214.3729 88.6976 76.0054 254.1503 245.6840 116.1609 116.8823 227.1596 210.6984 89.1194 83.0192 203.4031 194.9806 81.0293 74.1278 218.8212 215.3835 84.2066 81.4198 269.0628 254.2835 101.1951 99.6409 334.2556 341.2225 146.7331 127.9646 151.1930 132.5095 69.3347 64.1738 215.4425 103.6528 95.2591 226.6608 333.4530 299.1291 130.5292 96.8926 169.7071 57.4405 76.6002 178.0937 190.0995 157.0307 69.1915 71.5508 179.0916 78.6745 84.0503 166.2249 144.4897 166.4540 68.1305 65.9236 224.5344 202.6383 105.4611 98.1550 152.8067 172.0285 73.8534 53.3815 206.0170 169.8712 175.8145 74.8789 197.4375 77.2880 191.9915 179.7919 81.6188 71.0201 98.1239 97.1550 Sarcosine 1.4419 1.3963 6.3232 6.0213 3.1094 2.8150 5.4571 4.8358 1.0018 1.0806 2.0897 2.1516 1.2822 1.3921 2.2915 2.1959 1.3593 1.6495 4.7600 4.9867 1.0127 0.9834 2.2164 2.0541 0.9241 1.0245 4.7409 5.0178 1.4215 1.3625 3.6497 3.3888 1.0125 0.8886 6.0971 6.2791 0.7381 0.7347 3.1648 2.8341 1.0755 1.0929 2.7302 2.8055 1.1852 1.2720 3.3774 3.4693 1.4594 1.3568 6.5587 6.2158 3.1155 2.9055 4.0756 3.7263 1.0310 0.9374 1.9717 2.0211 2.0164 1.6140 2.1691 1.9586 1.5393 1.4217 3.0620 2.9757 0.6866 0.6807 2.3019 2.2540 0.9758 0.9790 2.7024 2.6239 0.8483 3.6049 3.4581 1.0057 1.0064 0.8625 5.9063 6.0859 0.9522 0.7693 1.8612 1.6878 1.1846 3.3480 3.3034 1.1386 1.1149 2.5457 2.4378 1.1797 1.5751 1.3395 4.6298 4.8638 1.3853 1.2352 3.7146 4.1230 1.2969 1.1447 4.4848 4.7004 0.8173 0.9243 4.3348 4.2308 1.3426 1.4513 2.3970 2.1480 1.4937 1.3337 3.1209 3.5839 1.1314 0.2309 1.4518 1.5948 1.0497 1.0274 2.3532 2.7448 2.0920 1.8066 1.4510 1.7031 0.8095 0.9528 3.9291 4.0235 1.3563 1.4022 2.5152 2.4338 1.3171 1.2977 2.0567 2.0291 1.5073 1.4409 3.3954 3.2972 1.1163 1.2518 4.8520 4.4145 1.4184 1.3496 4.3948 4.6513 1.2101 4.2664 4.0765 1.3089 1.0664 0.9204 4.5376 4.1678 1.1372 2.0630 2.5847 1.2542 1.5064 1.2946 3.0970 2.7557 0.8806 1.2298 1.2238 0.9505 0.7497 0.7751 2.0520 2.2707 1.5650 1.5376 1.5422 1.7545 0.7330 0.7600 3.6508 3.2237 1.3392 1.1635 1.0863 2.7082 1.3589 2.9177 1.1863 1.1307 2.3558 2.3113 3.0030 3.0688 Serine 115.7343 124.6400 58.2446 54.7572 91.3439 87.7486 47.9042 45.8979 94.6787 88.8875 59.7328 70.8801 81.8691 87.1102 49.1339 48.7494 96.5249 110.7762 58.3966 62.8418 98.3902 92.6446 50.5687 45.5811 106.2777 122.1810 70.7584 55.5237 106.7880 99.0918 50.2309 54.4833 112.0152 122.7594 65.9813 65.4307 95.7555 89.3828 55.9434 55.3361 69.4304 69.7211 29.2307 28.3474 83.7296 88.4467 41.3462 42.4112 106.6526 93.5734 57.0994 64.7987 103.4311 82.1964 31.4851 44.6006 78.1010 82.7962 59.0768 50.9863 91.6069 90.6593 39.5856 33.9625 73.9498 82.3292 47.0407 158.2482 92.0741 79.9036 51.6669 45.6408 78.9194 93.9697 44.5507 36.3633 91.4895 43.2651 54.6241 114.9070 113.1135 104.1643 45.7157 47.3050 72.6446 74.6667 36.4652 35.5322 82.8384 31.3935 29.4131 67.3674 65.1675 32.6948 36.3866 80.7073 115.6515 119.7176 35.1538 38.1151 73.0070 76.8249 38.9719 37.6863 105.9618 117.2320 58.0518 60.4310 83.5144 92.0445 57.5796 54.3454 81.6636 79.0976 39.1814 34.6914 115.2131 109.9790 65.6731 82.1534 89.1130 109.8008 52.2265 52.6185 79.4056 89.3781 71.0904 70.3174 81.8134 78.4498 40.3080 45.9215 67.6282 61.4421 31.1319 26.8179 56.1020 58.6404 33.1511 30.9810 69.8244 66.5681 29.5765 32.6656 83.0743 86.2550 48.1559 42.1080 108.5720 88.4994 37.4551 39.8113 76.3942 71.8809 45.0539 45.0175 98.0646 60.4285 51.9008 96.5536 109.1112 97.9571 60.3386 62.9803 85.0373 28.3096 44.1646 84.7280 93.2001 86.2629 55.7130 43.5952 75.4564 38.7830 37.1893 79.5598 66.4912 112.8736 52.4712 49.7046 76.5425 86.8310 33.1765 40.9004 58.4652 58.4684 39.5558 25.4527 71.3759 63.0853 54.9115 32.5927 70.3069 38.1074 60.2250 57.8883 30.6109 33.6538 41.2779 42.1938 Taurine 42.9912 45.7458 36.6753 36.2478 29.4181 31.6066 26.4035 29.6083 43.2290 54.7330 30.6472 38.4414 40.3537 42.5303 42.2485 45.4445 29.4942 35.4989 23.6603 28.6725 37.7020 31.7044 28.1923 27.3834 44.7129 33.0887 36.4035 31.3291 50.9820 45.2969 45.4233 44.1475 52.9641 48.5317 37.8827 35.9004 41.9500 40.2429 35.4899 42.3601 30.8007 32.1737 29.4219 31.9751 43.7574 46.0049 34.7094 28.4849 44.9156 43.6609 34.6189 36.6052 33.1044 26.2622 25.1040 28.5238 43.0135 36.4696 38.2276 31.2198 54.3682 42.4829 50.4185 43.2199 32.7285 34.4017 24.6275 64.2010 31.4697 24.2212 29.5976 26.8940 36.3380 38.6065 41.0764 32.4003 47.4897 34.8869 51.2056 45.9591 58.6029 58.5894 46.5423 42.8190 39.5578 37.7430 33.2053 27.1683 33.9707 30.3342 28.4710 41.6197 44.3964 40.2746 38.2467 35.7460 43.2770 42.4929 31.8689 36.7877 48.9143 47.7468 28.4495 29.9540 38.2590 39.4351 27.7436 29.9485 36.8390 42.4693 28.9696 29.6698 60.2845 47.7915 46.4280 43.7130 35.3370 35.1767 32.3982 25.4198 44.1433 52.8606 34.7102 37.4964 38.7606 41.6267 39.0515 37.5106 40.6515 35.7397 44.2395 36.0278 45.0555 44.2674 40.5174 29.2518 41.9265 42.7020 38.3628 41.5711 41.5159 37.4975 35.2503 32.4346 32.6111 36.6809 29.5737 27.7901 40.5115 45.0091 32.9310 34.8641 49.5769 44.1989 41.1770 36.6047 36.4620 37.3142 31.6259 36.2551 45.3980 40.9401 43.4540 32.7358 54.3679 24.5909 41.5769 55.4311 47.4187 36.9662 28.4239 32.5184 45.1216 38.6805 40.3232 48.9021 47.1170 53.9794 50.9720 42.9818 46.5519 42.1873 39.4346 43.0519 51.6588 49.2499 45.4620 33.9332 35.1088 36.8623 40.2564 45.3841 32.5268 39.6414 48.1044 42.8566 39.1660 43.2776 32.5497 32.3961 Threonine 111.0711 109.7910 197.0546 184.4413 170.0885 170.2414 260.7562 250.6853 114.3960 119.3343 216.1502 235.2101 119.7703 135.1072 268.6300 257.2026 133.2828 141.5265 289.1636 283.9945 157.7312 161.3715 273.6478 261.9592 168.5756 168.7152 316.0947 327.9108 214.2196 210.5817 305.7800 293.0194 177.3166 166.2492 291.7142 300.4300 104.8645 104.5793 258.1187 238.2868 112.5386 104.8978 214.4045 216.3937 140.5382 145.1083 282.7385 275.0549 108.0459 104.2206 213.1670 202.8776 167.8106 148.9480 220.6261 230.3697 92.6820 88.0622 188.8796 183.1024 146.6325 127.8321 237.7458 218.1760 139.0622 137.2007 235.8796 306.7615 151.5916 140.1909 276.7037 273.6348 164.8234 164.0735 257.0871 238.1320 184.8109 296.3691 245.4809 193.1419 177.6472 170.6553 288.9650 290.8828 109.3654 101.3836 198.1543 197.6255 118.0315 211.2157 211.1235 118.8998 114.4090 241.2057 232.9462 115.8427 224.9555 206.6545 225.3295 210.1850 98.9942 92.1880 186.0544 206.9790 113.5315 101.0105 220.4462 266.8749 99.3248 122.6612 203.2788 210.1671 92.3388 102.5591 247.3871 232.5586 134.2449 124.4038 221.8068 261.3569 111.6594 83.9118 225.8295 246.0195 146.7179 138.9765 240.5343 258.9799 101.6388 103.2001 228.2004 243.6959 105.2114 158.0403 248.4491 248.5455 96.5989 94.8456 193.8379 167.8579 124.0515 123.8034 199.7841 206.3727 123.5640 122.9283 216.4471 226.5690 197.2150 208.8108 272.1443 262.4420 96.5897 93.3144 202.7404 213.5057 137.0828 253.3047 245.9661 112.6532 151.1003 139.3040 266.0142 237.5544 107.6248 194.4292 264.7615 106.0300 130.4877 118.6414 222.6760 200.0694 107.2000 235.6634 235.6203 111.0903 93.8507 100.8541 207.5187 208.0073 112.5979 107.8175 239.1265 256.5093 108.4224 104.1600 251.0770 188.7825 89.1437 76.3302 76.5202 173.8222 94.1859 191.7550 110.2869 101.1689 192.1899 193.5612 192.1889 185.3800 Tryptophan 58.1561 59.9439 93.0156 89.0954 81.6770 86.5721 92.2343 102.7334 76.8469 71.5173 105.4783 116.7287 51.1844 56.1648 96.0713 101.0883 39.4961 39.8968 75.6835 78.8343 57.9353 54.1067 75.1154 78.0562 40.8600 41.8716 64.1739 64.4708 55.6213 52.4773 68.9143 76.6797 49.9802 43.8719 81.8821 80.9055 44.0707 44.0859 82.0307 75.7720 52.8290 49.1617 76.8471 79.0649 59.3278 58.2751 78.6644 78.3947 59.0764 56.6805 83.1859 87.0716 76.8498 71.5056 87.8166 95.8622 79.1620 76.3316 118.0134 115.1530 59.4948 47.0200 84.6214 81.3296 45.8837 41.5193 80.7195 90.2193 52.1970 48.3367 73.0632 77.1274 45.1986 46.6643 72.1906 77.7585 54.6921 72.1188 76.6903 57.6379 50.1508 45.8141 87.8388 90.2158 62.7921 55.3021 77.5826 84.2430 54.9659 77.0324 80.0705 61.4076 57.5048 88.2655 86.5717 53.2264 78.5897 74.5095 91.9499 94.6230 54.4192 56.6363 73.2439 81.4543 57.0397 57.6631 74.0524 83.9782 46.9103 57.9942 78.9035 77.2176 55.8458 57.5083 84.7136 88.8542 58.4902 58.3210 77.7674 83.1729 58.2846 44.2839 85.2800 86.9262 43.6657 39.9167 72.0272 70.2683 67.0592 62.9133 104.3640 104.8654 50.0459 41.4988 75.5513 79.4576 64.1175 64.6264 96.4259 92.0101 57.4582 57.8511 90.9151 93.6791 53.2238 47.6991 79.2507 81.6963 62.8106 64.6884 99.4141 98.5691 55.7565 55.5010 86.0217 91.8608 31.0627 87.8761 93.5660 57.7878 56.5305 52.4654 97.7921 82.4069 49.4108 63.5783 82.9722 52.1200 68.1934 60.4065 85.2843 87.1618 58.6818 99.0579 98.0437 61.7920 49.8644 53.1280 92.9965 89.7953 70.3073 71.4164 113.6300 107.5738 46.6443 44.4917 75.5877 65.2430 60.4788 62.2696 66.4571 94.1658 62.6988 98.0169 58.3741 52.0417 87.3763 87.4511 93.9669 86.6501 Tyrosine 64.9067 68.2752 47.7851 45.6971 129.4397 121.5208 56.1465 59.1813 96.7448 94.5224 69.4035 75.2111 68.3664 82.0550 78.1742 69.7624 46.5915 48.3828 69.1917 73.9579 58.6718 62.9902 61.2987 61.9237 47.7652 48.0572 54.9035 54.4603 86.5028 88.2299 53.0730 49.7075 58.9320 58.0904 61.0191 58.5282 69.8269 64.2224 77.3930 75.6559 49.7893 45.3587 35.6038 39.2931 63.1973 70.7886 71.4515 65.5233 55.8356 59.3218 52.3200 48.6160 132.6480 111.5317 60.0185 64.4009 101.4950 93.9398 60.7990 64.8800 100.3228 82.3865 56.8724 55.1141 62.0816 52.8707 53.9650 89.3491 42.9091 37.3253 53.0652 49.7210 60.4783 62.1809 47.5872 46.4651 81.2405 47.9700 50.2412 88.0702 65.5075 63.0449 67.0601 80.7810 68.5369 65.4115 53.2637 48.2048 46.8788 29.9785 31.5916 76.1426 70.2042 67.4729 68.0176 45.6956 110.6674 105.0224 41.9450 40.8071 71.8177 67.5638 55.1632 58.0424 58.5324 59.6476 68.6818 75.7740 52.9009 65.3821 44.8762 48.0524 73.9412 74.3872 59.7558 52.5879 88.5771 86.2186 59.3312 71.7174 62.1566 47.9608 59.7019 63.2917 75.4026 72.5156 49.1906 54.8292 93.9202 107.9842 57.4056 58.3186 59.0820 50.4687 56.7814 56.9870 76.1830 71.8645 42.7931 38.0264 81.8600 76.4356 54.1756 59.6117 72.8408 67.1003 45.4670 49.7159 93.7271 89.8988 40.6038 39.6266 75.8096 69.3287 56.5782 56.5025 67.8507 69.7826 74.9577 73.1537 74.3048 69.1613 56.3923 49.2742 59.3188 41.2249 63.6152 60.9305 125.4401 105.6837 81.4887 74.5016 78.6493 54.7267 65.6772 82.0846 82.1818 88.8599 58.0300 57.9664 101.0473 107.8318 57.3818 61.5942 56.8232 61.6367 61.5255 43.5563 70.0356 70.2313 67.1331 51.0311 70.2453 52.6987 78.6578 71.4801 54.0370 56.4345 46.2138 44.7448 Valine 296.4917 300.4255 653.6186 641.6199 423.3415 443.9907 836.6489 867.7810 311.0218 317.6499 638.2530 742.5983 365.6837 440.1104 971.0258 971.6022 295.3111 284.1829 560.9404 556.2957 256.4131 275.1503 512.8758 513.9412 266.5131 240.8646 460.0537 472.3262 375.5047 386.3183 704.0617 659.9668 235.8330 219.7960 580.1656 523.2987 253.9556 227.0916 593.9086 590.7012 257.7321 260.9701 605.7579 593.5759 307.3774 309.9453 734.2555 749.6370 273.7820 255.2684 639.1332 627.4381 455.3934 396.4646 900.0135 917.1816 306.0769 290.4078 733.8473 642.8356 420.8266 348.1599 860.3338 879.4478 249.5834 224.4121 532.9546 611.2280 248.8306 239.8884 497.1366 527.7387 220.5258 232.0555 545.1695 541.2614 314.9745 636.9013 624.8028 324.9490 234.0150 224.6029 506.5496 570.3852 253.4100 234.1968 614.9937 651.8328 273.8618 580.5142 603.9608 317.6859 313.7618 801.5895 772.9303 267.6256 421.7325 419.6030 666.8189 694.0750 281.3100 269.2435 577.8942 587.7839 321.6958 318.0772 636.5144 703.4815 225.9181 264.7432 597.9630 552.3574 430.6048 377.2093 1090.2519 1044.4517 329.8286 315.5676 612.1402 639.9197 351.6370 282.9375 660.4622 719.4979 224.8840 218.1934 403.2209 444.4054 401.0140 395.0978 861.2559 904.3018 272.6042 348.6153 641.8049 675.1224 304.5173 310.7504 743.3472 709.6640 267.1826 248.3062 533.2413 535.6026 298.4570 273.6149 625.3642 631.6001 429.7949 377.4885 786.1190 779.0301 292.1123 272.6492 626.8821 732.3799 304.4791 635.8640 575.7455 249.0525 254.4330 259.6485 655.4914 582.0945 324.8902 642.8620 907.7676 343.6865 372.0847 357.1595 643.1613 655.2514 331.4066 771.8364 778.8396 350.4273 224.4795 244.6118 550.0108 592.9499 310.9529 320.3934 802.0770 884.2845 247.8002 228.7135 638.0733 503.5115 266.9788 276.7009 297.6275 702.5362 272.0211 756.9561 227.8856 220.7413 487.4045 496.0157 601.5967 593.2519 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name moverz_quant ri ri_type pubchem_id inchi_key kegg_id other_id other_id_type 1-Methylhistidine' 92105 MAYO_ID 3-Methylhistidine' MAYO_ID Alanine 5950 MAYO_ID allo-Isoleucine 99288 MAYO_ID alpha-Aminoadipic-acid 469 MAYO_ID alpha-Amino-N-butyric-acid 6657 MAYO_ID Arginine 6322 MAYO_ID Asparagine 6267 MAYO_ID Aspartic Acid 5960 MAYO_ID beta-Alanine' MAYO_ID beta-Aminoisobutyric-acid 439434 MAYO_ID Citrulline 9750 MAYO_ID Cystathionine 1 MAYO_ID Cystine 595 MAYO_ID Ethanolamine 700 MAYO_ID Glutamic Acid 33032 MAYO_ID Glutamine 5961 MAYO_ID Glycine 750 MAYO_ID Histidine 6274 MAYO_ID Hydroxylysine 2 MAYO_ID Hydroxyproline 11137200 MAYO_ID Isoleucine 6306 MAYO_ID Leucine 6106 MAYO_ID Lysine 5962 MAYO_ID Methionine 6137 MAYO_ID Ornithine 6262 MAYO_ID Phenylalanine 6140 MAYO_ID Phosphoethanolamine 1015 MAYO_ID Proline 145742 MAYO_ID Sarcosine 1088 MAYO_ID Serine 5951 MAYO_ID Taurine 1123 MAYO_ID Threonine 6288 MAYO_ID Tryptophan 6305 MAYO_ID Tyrosine 6057 MAYO_ID Valine 6287 MAYO_ID METABOLITES_END #END