#METABOLOMICS WORKBENCH jburgess_20150629_9470891_mwtab.txt DATATRACK_ID:333 TEXT OUTPUT STUDY_ID:ST000223 ANALYSIS_ID:AN000332 PROJECT_ID:PR000183 VERSION 1 CREATED_ON 10-02-2015 #PROJECT PR:PROJECT_TITLE Metabolic Aberrations in Barth Syndrome PR:PROJECT_TYPE Metabolomics PR:PROJECT_SUMMARY The overall objective of thispilot research project is to investigate metabolic PR:PROJECT_SUMMARY mechanisms involved in disturbed intermediary metabolism in Barth Syndrome. PR:PROJECT_SUMMARY Barth Syndrome (BTHS) is x-linked disorder characterized mainly by dilated PR:PROJECT_SUMMARY cardiomyopathy, skeletal muscle weakness and neutropenia. BTHS is caused by PR:PROJECT_SUMMARY defects in Tafazzin, an enzyme responsible for modifying the acyl chain moieties PR:PROJECT_SUMMARY of cardiolipin, a critical phospholipid of the mitochondrial inner membrane. PR:PROJECT_SUMMARY While a few comprehensive clinical studies of BTHS have been published detailing PR:PROJECT_SUMMARY its cardiac and hematologic features, descriptions of its biochemical PR:PROJECT_SUMMARY characteristics are limited. PR:INSTITUTE Johns Hopkins University PR:DEPARTMENT Department of Pediatrics PR:LAST_NAME Vernon PR:FIRST_NAME Hilary PR:ADDRESS 733 N. Broadway St., Baltimore, MD 21205 PR:EMAIL hvernon1@jhmi.edu PR:PHONE (443) 923-2783 #STUDY ST:STUDY_TITLE Metabolic Aberrations in Barth Syndrome ST:STUDY_TYPE Metabolomic analysis of plasma samples ST:STUDY_SUMMARY 1) Characterize plasma metabolome in Barth Syndrome 2) To implement targeted, ST:STUDY_SUMMARY quantitative studies on prospective biomarkers and metabolites of interest ST:STUDY_SUMMARY derived from the non-targeted phase. ST:INSTITUTE RTI International ST:DEPARTMENT Discovery Science Technology ST:LABORATORY NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC) ST:LAST_NAME Sumner ST:FIRST_NAME Susan ST:ADDRESS 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA ST:EMAIL ssumner@rti.org ST:PHONE 919-541-7479 ST:NUM_GROUPS 2 ST:TOTAL_SUBJECTS 37 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - SVM0109 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0205 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0213 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0310 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0312 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0315 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0319 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0321 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0322 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0323 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0402 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0406 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0408 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0416 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0420 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0501 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0503 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0504 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0507 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0511 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0514 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0517 Type:Case SUBJECT_SAMPLE_FACTORS - SVM0518 Type:Case SUBJECT_SAMPLE_FACTORS - SVCM0221 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0301 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0305 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0307 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0308 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0313 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0315 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0403 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0416 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0417 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0418 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0419 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0511 Type:Control SUBJECT_SAMPLE_FACTORS - SVCM0520 Type:Control SUBJECT_SAMPLE_FACTORS - SVPool_1 Type:Pool SUBJECT_SAMPLE_FACTORS - SVPool_2 Type:Pool SUBJECT_SAMPLE_FACTORS - SVPool_3 Type:Pool #COLLECTION CO:COLLECTION_SUMMARY All participants have been carefully phenotyped and have a molecular CO:COLLECTION_SUMMARY confirmation of BTHS. In order to mitigate the potential effects of CO:COLLECTION_SUMMARY intercurrent illness in individual patients, plasma samples were collected under CO:COLLECTION_SUMMARY controlled conditions, while the patient is in a homeostatic state of wellness CO:COLLECTION_SUMMARY (outpatient setting). We controlled for nutritional effects by selecting CO:COLLECTION_SUMMARY samples hta thave amino acid profiles consistent with 4-6 hours of fasting. All CO:COLLECTION_SUMMARY samples were collected in an EDTA treated collection tube, plasma was separated CO:COLLECTION_SUMMARY via centrifugation and has been stored in a controlled setting at -80 degrees CO:COLLECTION_SUMMARY Celsius since collection. #TREATMENT TR:TREATMENT_SUMMARY none #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Aliquots of plasma samples (125 µL) were transferred into pre-labeled 2.0 mL SP:SAMPLEPREP_SUMMARY low-bind Eppendorf tubes for experimental samples. For all samples 125 µL of SP:SAMPLEPREP_SUMMARY 0.9% Saline in D2O (containing 2 mM Formate (chemical shift indicator) and 0.2% SP:SAMPLEPREP_SUMMARY NaN3 (to prevent bacterial growth)) was added to each tube and were vortexed for SP:SAMPLEPREP_SUMMARY 2 min at 5000 rpm. The samples were then centrifuged at 16,000 rcf for 2 min. SP:SAMPLEPREP_SUMMARY Total pools of the samples were prepared (by using 12 µL of each study sample) SP:SAMPLEPREP_SUMMARY to serve as QC samples, and 125 µL aliquots of QC samples were processed in SP:SAMPLEPREP_SUMMARY the same way as described above for study samples. A 200 µL aliquot of the SP:SAMPLEPREP_SUMMARY samples were then transferred into 3 mm NMR tubes (Bruker-Biospin, Switzerland), SP:SAMPLEPREP_SUMMARY which were kept in a cooler with freeze packs until data acquisition. SP:PROCESSING_STORAGE_CONDITIONS 4°C SP:SAMPLE_RESUSPENSION 0.9% Saline in D2O SP:SAMPLE_SPIKING Formate #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE - CH:INSTRUMENT_NAME - CH:COLUMN_NAME - #ANALYSIS AN:LABORATORY_NAME DHMRI AN:ANALYSIS_TYPE NMR AN:SOFTWARE_VERSION Top Spin 3.2 AN:OPERATOR_NAME Keven Knagge, Wimal Pathmasiri AN:DETECTOR_TYPE NMR AN:DATA_FORMAT Bruker FID #NMR NM:INSTRUMENT_TYPE FT NMR NM:NMR_EXPERIMENT_TYPE 1D 1H NM:PULSE_SEQUENCE Yes NM:PULSE_WIDTH 41967 NM:POWER_LEVEL Deuterium NM:RECEIVER_GAIN 1 mM (Formate) NM:OFFSET_FREQUENCY 950 MHz NM:PRESATURATION_POWER_LEVEL 5mm Cryogenically Cooled ATMA NM:CHEMICAL_SHIFT_REF_CPD D20 NM:TEMPERATURE 5mm NM:NUMBER_OF_SCANS Topshim (Gradient) NM:DUMMY_SCANS cpmgpr1d NM:ACQUISITION_TIME yes NM:RELAXATION_DELAY 8.11 NM:SPECTRAL_WIDTH 12.589 W NM:NUM_DATA_POINTS_ACQUIRED 4 NM:REAL_DATA_POINTS 4468.1 Hz NM:ZERO_FILLING Formate NM:APODIZATION 298 K NM:BASELINE_CORRECTION_METHOD 128 NM:CHEMICAL_SHIFT_REF_STD 16 NM:INSTRUMENT_NAME Bruker Avance III NM:SPECTROMETER_FREQUENCY - #NMR_BINNED_DATA NMR_BINNED_DATA:UNITS Peak area NMR_BINNED_DATA_START Bin range(ppm) SVM0109 SVM0205 SVM0213 SVM0310 SVM0312 SVM0315 SVM0319 SVM0321 SVM0322 SVM0323 SVM0402 SVM0406 SVM0408 SVM0416 SVM0420 SVM0501 SVM0503 SVM0504 SVM0507 SVM0511 SVM0514 SVM0517 SVM0518 SVCM0221 SVCM0301 SVCM0305 SVCM0307 SVCM0308 SVCM0313 SVCM0315 SVCM0403 SVCM0416 SVCM0417 SVCM0418 SVCM0419 SVCM0511 SVCM0520 SVPool_1 SVPool_2 SVPool_3 0.75...0.77 0.000926 0.000346 0.000657 0.000854 0.000805 0.00101 0.00121 0.000453 0.00116 0.000786 0.00138 0.000925 0.00091 0.000963 0.000867 0.00114 0.000596 0.000913 0.000704 0.000902 0.000592 0.000909 0.000507 0.000723 0.000725 0.000874 0.00119 0.000658 0.000538 0.00107 0.000848 0.00051 0.000921 0.000505 0.000111 0.00111 0.0007 0.000722 0.000558 0.000727 0.77...0.79 0.00154 0.000694 0.00134 0.00139 0.00129 0.00158 0.00208 0.000975 0.00161 0.00116 0.00206 0.00143 0.00151 0.00143 0.00138 0.00187 0.00109 0.00145 0.00121 0.00145 0.00101 0.0015 0.000949 0.00131 0.00132 0.00127 0.00174 0.00117 0.000836 0.00171 0.00128 0.00112 0.0014 0.000861 0.00043 0.00171 0.00119 0.00131 0.00101 0.00128 0.79...0.81 0.00744 0.00384 0.0054 0.0052 0.00297 0.00603 0.00811 0.00513 0.00578 0.00447 0.00682 0.00557 0.00466 0.00607 0.00621 0.00571 0.00275 0.00543 0.00425 0.00631 0.00464 0.00522 0.00481 0.00509 0.0071 0.00356 0.00461 0.00363 0.00249 0.00585 0.00432 0.00518 0.00491 0.00341 0.00412 0.00453 0.00387 0.00473 0.00456 0.00473 0.81...0.86 0.0523 0.0512 0.0764 0.0677 0.0205 0.0682 0.0667 0.0663 0.0702 0.0621 0.0552 0.0711 0.063 0.0604 0.0667 0.0393 0.0234 0.0533 0.0345 0.051 0.0416 0.0343 0.0614 0.0358 0.069 0.0237 0.0346 0.0245 0.0144 0.0443 0.0478 0.0617 0.0473 0.0488 0.0419 0.0242 0.0283 0.0456 0.0455 0.0462 0.86...0.90 0.0345 0.0371 0.0236 0.0373 0.0312 0.0383 0.0222 0.0364 0.0332 0.045 0.0335 0.0247 0.037 0.03 0.031 0.0362 0.0273 0.0255 0.0371 0.0259 0.0384 0.0535 0.0302 0.0517 0.0325 0.0224 0.0325 0.0285 0.0218 0.0511 0.067 0.0403 0.053 0.0658 0.0341 0.0423 0.0296 0.0368 0.0363 0.0396 0.90...0.96 0.0152 0.0205 0.0176 0.0211 0.0323 0.0207 0.0181 0.0223 0.0282 0.0211 0.0232 0.0184 0.02 0.0213 0.0224 0.0251 0.0235 0.0217 0.0331 0.0231 0.016 0.0247 0.0205 0.0217 0.019 0.0179 0.0282 0.0177 0.0146 0.0225 0.0181 0.0215 0.0209 0.0178 0.0147 0.024 0.0328 0.0202 0.0199 0.02 0.96...1.00 0.0055 0.00816 0.00887 0.0107 0.00756 0.00846 0.0062 0.0103 0.016 0.00928 0.0101 0.00862 0.01 0.0105 0.00935 0.00668 0.00551 0.0113 0.00547 0.00923 0.00722 0.0106 0.0103 0.00378 0.00795 0.00942 0.00472 0.00709 0.00423 0.00949 0.00736 0.0109 0.0081 0.00759 0.00507 0.00988 0.00803 0.00828 0.00875 0.00877 1.00...1.04 0.00385 0.00606 0.00608 0.00685 0.0073 0.00594 0.00441 0.00681 0.0124 0.00675 0.00757 0.00586 0.00752 0.00777 0.00662 0.00683 0.00569 0.00826 0.00823 0.00665 0.00537 0.00721 0.00754 0.00459 0.00558 0.00704 0.00616 0.00494 0.00297 0.00708 0.00496 0.00766 0.00553 0.00529 0.00302 0.00747 0.00863 0.00607 0.00626 0.00621 1.04...1.07 0.000879 0.000821 0.000956 0.00115 0.00219 0.00137 0.00107 0.00117 0.00219 0.000919 0.0014 0.00107 0.00109 0.00111 0.000897 0.00141 0.00133 0.00101 0.00171 0.00111 0.00108 0.00134 0.00103 0.00127 0.000994 0.00103 0.00135 0.00105 0.000818 0.00129 0.000986 0.0011 0.000942 0.000816 0.000661 0.00153 0.00163 0.00102 0.00114 0.00133 1.07...1.09 0.000638 0.000369 0.000544 0.000472 0.000713 0.000671 0.000778 0.000522 0.00064 0.000511 0.000905 0.000496 0.000601 0.000604 0.000476 0.0008 0.000534 0.000641 0.000582 0.000528 0.000614 0.000722 0.000573 0.000524 0.000456 0.000522 0.000901 0.000483 0.000414 0.000757 0.00061 0.000491 0.000657 0.000444 0.000267 0.000842 0.000627 0.000638 0.000547 0.000611 1.09...1.11 0.000888 0.000548 0.00062 0.000653 0.000993 0.000982 0.00125 0.000818 0.00109 0.000806 0.00125 0.000836 0.000774 0.000789 0.000811 0.000964 0.00045 0.000828 0.000623 0.001 0.000698 0.000903 0.000618 0.000709 0.000745 0.000693 0.000945 0.000596 0.000416 0.000975 0.00082 0.000622 0.000835 0.000563 0.000303 0.000965 0.000621 0.000776 0.000628 0.000747 1.11...1.13 0.00138 0.000844 0.000796 0.000863 0.00146 0.00139 0.00478 0.0011 0.00189 0.00108 0.00182 0.000786 0.00288 0.00114 0.00101 0.00199 0.000789 0.0011 0.002 0.000938 0.000787 0.00112 0.00091 0.000939 0.00126 0.000867 0.00126 0.00197 0.000588 0.00229 0.000938 0.00104 0.000888 0.00068 0.000423 0.00124 0.00131 0.00124 0.00111 0.00131 1.13...1.15 0.00199 0.00164 0.00167 0.00156 0.00269 0.0025 0.00249 0.00151 0.00192 0.00163 0.0024 0.00161 0.00156 0.0018 0.00159 0.00266 0.0016 0.00196 0.00178 0.00187 0.00145 0.00183 0.00163 0.00168 0.00169 0.00152 0.00234 0.00162 0.00115 0.00191 0.00146 0.00144 0.00161 0.0011 0.000968 0.00208 0.00204 0.00165 0.00152 0.00167 1.15...1.17 0.00328 0.00261 0.00281 0.00245 0.00437 0.00417 0.00447 0.00267 0.00309 0.00274 0.0037 0.0028 0.00256 0.00281 0.00278 0.00355 0.00214 0.00302 0.00263 0.00313 0.0024 0.0029 0.00271 0.00273 0.00271 0.00223 0.00326 0.00247 0.00158 0.00324 0.00241 0.00227 0.00241 0.0018 0.00174 0.00347 0.00285 0.00266 0.00255 0.00265 1.17...1.19 0.0125 0.00556 0.00863 0.00528 0.0258 0.0278 0.0282 0.0113 0.015 0.00984 0.0102 0.0132 0.00695 0.00657 0.00847 0.00697 0.0049 0.00617 0.00723 0.01 0.00557 0.00658 0.00826 0.00862 0.0099 0.004 0.00643 0.0132 0.00458 0.00731 0.00461 0.00531 0.00498 0.00391 0.00383 0.0134 0.00574 0.00863 0.00783 0.00855 1.19...1.21 0.0132 0.0114 0.0114 0.0104 0.00544 0.0128 0.0127 0.0125 0.0125 0.0121 0.0133 0.0108 0.0106 0.0133 0.013 0.0103 0.00504 0.0115 0.01 0.0105 0.0112 0.0105 0.0117 0.00897 0.0134 0.00553 0.00806 0.0055 0.00377 0.0108 0.0102 0.0114 0.00986 0.00954 0.00794 0.0062 0.00584 0.00955 0.00937 0.00946 1.21...1.23 0.0201 0.02 0.0211 0.0196 0.00594 0.0231 0.0208 0.0224 0.0226 0.0223 0.0209 0.0199 0.0207 0.0217 0.0214 0.0144 0.00695 0.0186 0.0156 0.0164 0.0175 0.0169 0.0207 0.0142 0.0222 0.00745 0.0109 0.00707 0.00474 0.0181 0.0186 0.0205 0.0168 0.0195 0.0132 0.00856 0.0073 0.0159 0.0156 0.016 1.23...1.29 0.108 0.103 0.0632 0.0875 0.031 0.101 0.0642 0.107 0.09 0.124 0.0889 0.0676 0.108 0.0831 0.082 0.0722 0.0409 0.0716 0.0804 0.0633 0.107 0.134 0.0765 0.119 0.0867 0.0364 0.0527 0.0444 0.0335 0.143 0.18 0.107 0.142 0.166 0.0765 0.0683 0.0349 0.0911 0.0893 0.0979 1.29...1.35 0.126 0.0656 0.045 0.053 0.0756 0.0481 0.0414 0.0559 0.0472 0.0694 0.0593 0.0388 0.0893 0.0425 0.044 0.0534 0.0402 0.0525 0.1 0.0454 0.0548 0.0828 0.0355 0.0733 0.0534 0.033 0.0497 0.0451 0.0734 0.0688 0.0846 0.0603 0.0783 0.108 0.0503 0.152 0.0361 0.0681 0.066 0.0601 1.35...1.41 0.00789 0.00964 0.00661 0.00892 0.0107 0.0079 0.00602 0.00921 0.0089 0.00961 0.00781 0.00702 0.00874 0.00992 0.00791 0.00936 0.00999 0.00859 0.0123 0.00816 0.00827 0.0142 0.00825 0.0125 0.00855 0.00718 0.0101 0.00712 0.00607 0.00752 0.0109 0.0105 0.00876 0.0105 0.00956 0.00979 0.0116 0.00879 0.00891 0.00946 1.41...1.47 0.00977 0.00898 0.0112 0.0125 0.0126 0.00908 0.00979 0.00948 0.0109 0.00788 0.0122 0.0111 0.0149 0.0172 0.0108 0.0125 0.0124 0.0179 0.0162 0.0117 0.00863 0.0122 0.0115 0.0107 0.0085 0.0107 0.0119 0.00813 0.00681 0.00787 0.00979 0.0147 0.0105 0.0115 0.0109 0.0122 0.0163 0.0109 0.0108 0.0116 1.47...1.51 0.00277 0.00346 0.00366 0.00346 0.00226 0.00316 0.00247 0.00375 0.00334 0.00333 0.00286 0.00336 0.00349 0.0031 0.00344 0.0028 0.00258 0.0036 0.00271 0.00306 0.00338 0.00288 0.00408 0.00314 0.00376 0.00237 0.00293 0.0024 0.0016 0.00278 0.00308 0.00365 0.00305 0.00341 0.00356 0.00247 0.00348 0.00305 0.00313 0.00288 1.51...1.54 0.0017 0.00203 0.00136 0.0015 0.0012 0.00183 0.00108 0.00188 0.00155 0.00177 0.00153 0.00145 0.00174 0.00161 0.00143 0.00145 0.00122 0.00156 0.00189 0.00144 0.00197 0.00239 0.00176 0.00218 0.00178 0.00114 0.00142 0.00117 0.000831 0.00186 0.00213 0.00171 0.00185 0.00231 0.00173 0.00139 0.00159 0.00169 0.00161 0.0017 1.54...1.60 0.00919 0.00851 0.0032 0.00609 0.00396 0.00648 0.00287 0.00899 0.00697 0.00984 0.00612 0.00411 0.00783 0.00609 0.00529 0.00608 0.00471 0.00517 0.00735 0.0044 0.00858 0.0129 0.00485 0.0117 0.00631 0.00374 0.00561 0.00421 0.00338 0.0119 0.0167 0.00851 0.0134 0.0144 0.00732 0.0064 0.00512 0.00774 0.00753 0.0084 1.60...1.62 0.00128 0.00139 0.0012 0.00147 0.00166 0.00127 0.000987 0.00132 0.00149 0.0015 0.00125 0.00121 0.0013 0.00151 0.00118 0.00161 0.00159 0.00135 0.00209 0.00129 0.00128 0.00202 0.0012 0.00213 0.00143 0.00115 0.00185 0.00114 0.000934 0.0013 0.00151 0.00165 0.00139 0.00147 0.00154 0.00147 0.00219 0.0014 0.00132 0.00147 1.62...1.64 0.00147 0.00164 0.00142 0.00174 0.00276 0.00141 0.00131 0.00172 0.00173 0.0015 0.00134 0.00152 0.00128 0.00162 0.00143 0.00217 0.00206 0.00154 0.00233 0.00176 0.00148 0.00192 0.0016 0.00194 0.00189 0.00175 0.00223 0.00162 0.00116 0.00167 0.00153 0.00169 0.00188 0.00165 0.0019 0.00192 0.00303 0.00179 0.0018 0.00175 1.64...1.67 0.00244 0.00293 0.00279 0.00311 0.00481 0.00274 0.00277 0.00346 0.00365 0.00286 0.00308 0.00285 0.00241 0.00287 0.00293 0.00367 0.00381 0.00322 0.00353 0.00361 0.00249 0.00267 0.00312 0.00324 0.00343 0.00329 0.00441 0.00315 0.0024 0.00256 0.0022 0.0027 0.00309 0.00243 0.003 0.00358 0.00506 0.0031 0.00304 0.00281 1.67...1.73 0.00547 0.00628 0.00642 0.00596 0.00753 0.0046 0.00681 0.00759 0.00665 0.00623 0.00702 0.00666 0.00562 0.0056 0.00567 0.0075 0.00673 0.00745 0.00752 0.00793 0.00631 0.00463 0.00718 0.0039 0.00653 0.00631 0.00815 0.0058 0.00481 0.00474 0.00368 0.00475 0.00599 0.0044 0.00446 0.00757 0.00751 0.00678 0.00635 0.00495 1.73...1.75 0.000565 0.000622 0.000626 0.000748 0.000919 0.000528 0.000526 0.000649 0.000732 0.000526 0.000566 0.000566 0.000442 0.000487 0.000499 0.000867 0.000729 0.000707 0.00089 0.000665 0.000562 0.000427 0.000695 0.000678 0.000727 0.000608 0.0011 0.000587 0.000449 0.000446 0.000391 0.000561 0.000499 0.000543 0.0006 0.000692 0.000935 0.000649 0.000632 0.000654 1.75...1.81 0.00198 0.0023 0.00191 0.00201 0.00465 0.00166 0.00207 0.00234 0.00225 0.00185 0.00219 0.00224 0.00172 0.00203 0.00199 0.00444 0.00471 0.00234 0.00448 0.00241 0.00196 0.00176 0.00225 0.0029 0.00238 0.00284 0.0058 0.00203 0.00176 0.00202 0.00142 0.00182 0.0021 0.00167 0.00192 0.00311 0.00507 0.00237 0.0024 0.00223 1.81...1.83 0.000964 0.000634 0.000783 0.000745 0.00156 0.00054 0.000928 0.000737 0.000878 0.000682 0.000711 0.00142 0.000525 0.00091 0.000704 0.00181 0.00151 0.000938 0.00113 0.00111 0.000843 0.00117 0.00084 0.00082 0.00111 0.00178 0.00121 0.00114 0.000574 0.00117 0.000652 0.000939 0.00129 0.00101 0.00105 0.00212 0.00174 0.00132 0.0014 0.00129 1.83...1.89 0.00326 0.00408 0.00482 0.00598 0.00412 0.00431 0.00426 0.00486 0.00571 0.00449 0.00507 0.00425 0.00443 0.00544 0.00426 0.0032 0.00295 0.00582 0.00264 0.00517 0.00506 0.00452 0.0055 0.00212 0.00472 0.0047 0.00347 0.00375 0.00353 0.00315 0.00395 0.0041 0.00443 0.00388 0.00401 0.00411 0.00302 0.00437 0.0044 0.00424 1.89...1.91 0.00153 0.00258 0.0017 0.00174 0.00504 0.00237 0.00219 0.00197 0.00151 0.00155 0.00162 0.00179 0.00164 0.00139 0.00155 0.00248 0.00317 0.00153 0.00319 0.00209 0.00143 0.00269 0.00137 0.00271 0.0026 0.00274 0.00343 0.00309 0.00316 0.00196 0.000887 0.00118 0.00116 0.00102 0.00177 0.00227 0.00278 0.00215 0.00212 0.00207 1.91...1.93 0.00154 0.00138 0.00138 0.00152 0.0024 0.00154 0.00161 0.00154 0.00156 0.00134 0.0018 0.00134 0.00131 0.00163 0.00158 0.00216 0.00172 0.00167 0.00176 0.0018 0.00137 0.00143 0.0014 0.00154 0.00162 0.00138 0.00232 0.00133 0.00102 0.00151 0.00122 0.00144 0.00139 0.00115 0.00121 0.00161 0.00211 0.00138 0.00143 0.0015 1.93...1.95 0.00286 0.00269 0.00246 0.00264 0.00277 0.00278 0.00314 0.00287 0.00311 0.00289 0.00323 0.00255 0.00261 0.00299 0.003 0.00307 0.00209 0.00286 0.00258 0.00313 0.00257 0.00296 0.00293 0.00226 0.00303 0.00226 0.00289 0.00215 0.00158 0.00291 0.00254 0.0028 0.00267 0.00251 0.00205 0.00257 0.00247 0.00264 0.00261 0.00275 1.95...1.97 0.00557 0.00488 0.00521 0.00532 0.00332 0.00577 0.00606 0.00566 0.00602 0.00546 0.00598 0.00488 0.00522 0.00553 0.00557 0.00454 0.0029 0.00554 0.00485 0.0054 0.00488 0.00468 0.00533 0.00443 0.00627 0.0029 0.00454 0.0029 0.0021 0.00483 0.00461 0.00511 0.00445 0.00455 0.00367 0.00325 0.0032 0.0045 0.00436 0.00446 1.97...2.01 0.0198 0.02 0.0186 0.0204 0.0147 0.0221 0.0177 0.0218 0.0211 0.0238 0.0206 0.0175 0.0215 0.0183 0.0199 0.0183 0.0134 0.0188 0.019 0.0172 0.0208 0.021 0.0183 0.0218 0.0209 0.0104 0.0176 0.011 0.00819 0.0248 0.0268 0.022 0.023 0.0261 0.0158 0.0144 0.0158 0.0182 0.0181 0.019 2.01...2.07 0.0388 0.0418 0.0331 0.0339 0.0548 0.0356 0.0404 0.0397 0.036 0.0379 0.0396 0.036 0.0326 0.0384 0.0372 0.0394 0.0391 0.0378 0.0393 0.0414 0.0419 0.0431 0.0333 0.039 0.0371 0.029 0.0486 0.0288 0.0257 0.0406 0.0432 0.0376 0.0405 0.0389 0.0318 0.0418 0.044 0.0381 0.0384 0.0391 2.07...2.13 0.00862 0.0133 0.0124 0.0136 0.0117 0.0106 0.0105 0.0117 0.0138 0.0118 0.0127 0.00897 0.0108 0.0132 0.0121 0.00996 0.00872 0.0139 0.00841 0.0114 0.0115 0.00946 0.0141 0.00699 0.0117 0.0085 0.0088 0.00724 0.00686 0.00758 0.00935 0.0104 0.0083 0.00794 0.00896 0.00818 0.0119 0.00924 0.00931 0.00921 2.13...2.15 0.00119 0.00149 0.00138 0.00127 0.00152 0.00149 0.00117 0.00148 0.00179 0.00116 0.00118 0.00139 0.00127 0.00134 0.00124 0.00107 0.00112 0.00137 0.000998 0.00145 0.00119 0.00131 0.00166 0.00105 0.0015 0.00138 0.00115 0.000902 0.000682 0.00104 0.00102 0.00131 0.00116 0.00112 0.0014 0.000928 0.0014 0.00131 0.00131 0.00121 2.15...2.17 0.000584 0.00101 0.000705 0.000786 0.000943 0.000813 0.000477 0.000994 0.00111 0.000861 0.000812 0.000637 0.00082 0.000779 0.000596 0.000756 0.000747 0.00078 0.00086 0.000807 0.000926 0.000987 0.00082 0.000904 0.000807 0.00115 0.00081 0.000647 0.000476 0.000864 0.000832 0.000864 0.000735 0.000833 0.000803 0.000715 0.00105 0.000776 0.000813 0.000738 2.17...2.19 0.000924 0.00107 0.000669 0.000731 0.00113 0.00118 0.00076 0.00117 0.000961 0.000945 0.000912 0.000713 0.000899 0.000893 0.000677 0.000936 0.000953 0.000778 0.00111 0.00102 0.00101 0.00127 0.000917 0.00128 0.000976 0.00107 0.00105 0.00073 0.000597 0.00113 0.00111 0.000833 0.000989 0.0011 0.000848 0.000874 0.00108 0.000913 0.000949 0.000973 2.19...2.25 0.0139 0.00941 0.00702 0.00791 0.0121 0.0203 0.016 0.0146 0.0139 0.0126 0.00889 0.00926 0.0101 0.00681 0.00747 0.00754 0.0069 0.00631 0.00763 0.00789 0.00912 0.0136 0.0078 0.0125 0.00969 0.00471 0.0068 0.012 0.00488 0.0141 0.0165 0.00882 0.0137 0.0139 0.00785 0.00706 0.00686 0.0102 0.01 0.0107 2.25...2.27 0.00186 0.00231 0.00255 0.00187 0.00312 0.00523 0.00477 0.00388 0.00544 0.00423 0.00227 0.0029 0.00219 0.00227 0.00237 0.00243 0.00237 0.00215 0.0023 0.00251 0.0018 0.0027 0.00249 0.00262 0.00217 0.00223 0.00268 0.00207 0.00175 0.00208 0.002 0.00214 0.00195 0.00177 0.00201 0.00242 0.0029 0.00242 0.00249 0.0025 2.27...2.30 0.00469 0.00308 0.0042 0.00299 0.0128 0.0106 0.00947 0.00546 0.00637 0.00459 0.00438 0.00522 0.00342 0.00342 0.0042 0.00386 0.00427 0.00329 0.00442 0.00498 0.00282 0.00326 0.00409 0.0051 0.00495 0.00358 0.00527 0.00672 0.00301 0.00374 0.0024 0.00338 0.0028 0.00245 0.00317 0.00669 0.00552 0.00425 0.00446 0.00434 2.30...2.35 0.00512 0.00433 0.00492 0.0048 0.0114 0.00381 0.00369 0.00497 0.00503 0.00425 0.00536 0.0045 0.00443 0.00454 0.00455 0.00937 0.00856 0.00542 0.00697 0.00534 0.0038 0.00544 0.00437 0.0063 0.00425 0.0087 0.00839 0.00703 0.00539 0.00492 0.00338 0.00455 0.00434 0.00392 0.00414 0.00722 0.0148 0.00556 0.00558 0.0056 2.35...2.40 0.00771 0.00435 0.00617 0.0046 0.0136 0.00968 0.0112 0.00601 0.00708 0.00539 0.00571 0.00849 0.00512 0.00544 0.00524 0.00501 0.00658 0.00555 0.00595 0.00683 0.00494 0.00404 0.00578 0.00849 0.00662 0.00537 0.00754 0.00804 0.00365 0.00529 0.00331 0.0057 0.00471 0.0041 0.00542 0.0104 0.00628 0.0063 0.00667 0.0064 2.40...2.46 0.00696 0.00857 0.00981 0.00972 0.00447 0.00856 0.00907 0.00786 0.0093 0.00793 0.00924 0.0092 0.00751 0.01 0.00829 0.00262 0.00278 0.0099 0.00218 0.00816 0.00852 0.00362 0.0115 0.00305 0.00903 0.00337 0.00309 0.00353 0.00362 0.00536 0.00626 0.00785 0.00608 0.00556 0.00687 0.00516 0.0032 0.00626 0.00637 0.0061 2.46...2.49 0.000504 0.000598 0.000503 0.00126 0.00089 0.000595 0.000233 0.000723 0.000725 0.000457 0.000541 0.000569 0.000513 0.000749 0.000652 0.000653 0.000928 0.000664 0.000554 0.000662 0.00062 0.000454 0.000743 0.000828 0.000805 0.00169 0.000839 0.00105 0.000823 0.000578 0.000504 0.000737 0.000556 0.000563 0.000729 0.000939 0.000914 0.000679 0.000788 0.000765 2.49...2.52 0.00085 0.00095 0.00137 0.00182 0.00141 0.00118 0.00144 0.00162 0.00116 0.000986 0.00182 0.00139 0.00117 0.00143 0.00118 0.0017 0.00172 0.00169 0.00112 0.00177 0.00113 0.000839 0.00166 0.00132 0.0016 0.00269 0.00192 0.0018 0.00157 0.00092 0.000769 0.00122 0.00101 0.000965 0.00167 0.00169 0.00207 0.0014 0.00138 0.00143 2.52...2.58 0.00218 0.00212 0.00321 0.00283 0.0031 0.00182 0.00281 0.00403 0.00234 0.00218 0.00325 0.00305 0.0024 0.00344 0.00284 0.00268 0.00298 0.0035 0.00182 0.00589 0.00268 0.00235 0.00356 0.00246 0.00358 0.0473 0.00309 0.0548 0.0334 0.00218 0.00206 0.00307 0.00298 0.00263 0.00348 0.00369 0.00414 0.0148 0.0152 0.0148 2.58...2.60 0.0004 0.000556 0.000516 0.000557 0.000827 0.000971 0.000357 0.000853 0.000746 0.000487 0.000675 0.000377 0.000429 0.000564 0.000625 0.00084 0.000897 0.000631 0.0012 0.000742 0.000505 0.000378 0.000616 0.000775 0.000675 0.000953 0.00127 0.00106 0.001 0.000372 0.000356 0.000429 0.000476 0.000447 0.000469 0.000548 0.00102 0.000549 0.000753 0.000651 2.60...2.62 0.000606 0.000799 0.000967 0.00082 0.0012 0.000951 0.000577 0.000883 0.00165 0.000699 0.000848 0.000873 0.000776 0.000875 0.000769 0.00101 0.000957 0.000972 0.000685 0.00103 0.000676 0.00079 0.000851 0.000538 0.000905 0.00125 0.000959 0.00101 0.000808 0.000643 0.000542 0.000867 0.000844 0.000687 0.000609 0.000644 0.00113 0.000911 0.000869 0.000849 2.62...2.64 0.00059 0.000782 0.000708 0.000775 0.0012 0.000817 0.000607 0.0008 0.00111 0.00056 0.000842 0.000582 0.000652 0.000756 0.000733 0.000994 0.000701 0.000869 0.000577 0.000819 0.000586 0.000572 0.000801 0.000482 0.000791 0.00193 0.000957 0.00163 0.00123 0.000518 0.000491 0.000609 0.000661 0.000539 0.000521 0.000675 0.000846 0.000665 0.000707 0.00068 2.64...2.70 0.00585 0.00663 0.0078 0.00832 0.00831 0.00843 0.00824 0.00868 0.00785 0.00654 0.00903 0.00688 0.00684 0.00867 0.00821 0.0068 0.00677 0.00809 0.00554 0.00833 0.00651 0.00566 0.0071 0.00528 0.00834 0.025 0.00759 0.024 0.0181 0.00576 0.00551 0.00725 0.00576 0.00626 0.00678 0.00705 0.00815 0.0067 0.00737 0.00743 2.70...2.76 0.00632 0.00694 0.00568 0.00898 0.00615 0.00938 0.00601 0.00813 0.00847 0.0068 0.00722 0.00597 0.00757 0.00892 0.00806 0.00578 0.006 0.00655 0.00561 0.00668 0.00805 0.00999 0.00731 0.00898 0.00821 0.00496 0.00661 0.00415 0.0036 0.00896 0.0126 0.0101 0.00843 0.0116 0.0078 0.00552 0.00741 0.00635 0.00676 0.00837 2.76...2.80 0.00154 0.00171 0.00144 0.00234 0.00159 0.00221 0.00159 0.00203 0.00176 0.0018 0.00167 0.00187 0.00176 0.00211 0.00158 0.00189 0.00177 0.00145 0.00149 0.00164 0.00156 0.00265 0.00196 0.00232 0.0018 0.00129 0.00175 0.000942 0.000827 0.00333 0.00315 0.00249 0.00198 0.00347 0.00159 0.00143 0.00203 0.00172 0.00165 0.00185 2.80...2.82 0.000633 0.000787 0.000524 0.000767 0.00101 0.00081 0.000483 0.000745 0.000756 0.000774 0.000839 0.000696 0.000707 0.0007 0.000681 0.00101 0.000799 0.000709 0.000754 0.000781 0.000776 0.00101 0.000899 0.000933 0.000731 0.000926 0.000989 0.000703 0.000653 0.00232 0.00116 0.00075 0.000879 0.00111 0.000553 0.000956 0.000886 0.000801 0.000883 0.000854 2.82...2.84 0.000648 0.00054 0.000589 0.000478 0.001 0.000493 0.00058 0.000527 0.000545 0.000446 0.000791 0.000938 0.000473 0.000545 0.000467 0.000737 0.000737 0.000656 0.00102 0.000852 0.000556 0.000808 0.000643 0.000852 0.000595 0.00125 0.00106 0.00104 0.000664 0.001 0.000514 0.000733 0.000808 0.000705 0.000512 0.000852 0.000894 0.000807 0.00084 0.000739 2.84...2.86 0.000713 0.000657 0.00088 0.000643 0.0016 0.000641 0.00108 0.00101 0.000762 0.000921 0.00082 0.00102 0.000726 0.00109 0.000877 0.0013 0.00144 0.00114 0.000845 0.00132 0.000983 0.00076 0.0013 0.00109 0.000958 0.00151 0.00149 0.00162 0.00126 0.000838 0.000694 0.000786 0.000723 0.000633 0.000698 0.00102 0.00144 0.0011 0.00108 0.000984 2.86...2.91 0.00285 0.00289 0.00344 0.00341 0.00346 0.00322 0.00355 0.00341 0.00321 0.00284 0.00384 0.00382 0.00304 0.00404 0.0032 0.00351 0.00355 0.00381 0.00243 0.00351 0.00334 0.00274 0.00406 0.00342 0.0035 0.00297 0.00417 0.00268 0.00271 0.00297 0.00241 0.00342 0.00256 0.00251 0.00315 0.00397 0.00524 0.00319 0.00306 0.00315 2.91...2.93 0.00103 0.000878 0.00117 0.00106 0.00181 0.00116 0.00113 0.000999 0.00111 0.000857 0.00124 0.00133 0.000955 0.00138 0.00118 0.00159 0.0016 0.00137 0.00137 0.00132 0.00114 0.00116 0.00133 0.00148 0.00139 0.00192 0.00195 0.00124 0.00102 0.00114 0.000906 0.00149 0.00104 0.000937 0.00132 0.00166 0.00213 0.00108 0.00111 0.00134 2.93...2.96 0.00304 0.00271 0.0034 0.00309 0.00626 0.00333 0.00402 0.0032 0.00328 0.0028 0.00384 0.00385 0.00271 0.00375 0.00345 0.00454 0.00523 0.00365 0.00384 0.0038 0.00327 0.00288 0.00365 0.00451 0.00386 0.00426 0.00553 0.00411 0.00324 0.00313 0.00235 0.00344 0.00302 0.00253 0.00328 0.00494 0.00671 0.00349 0.00336 0.00345 2.96...3.02 0.00844 0.00816 0.00983 0.00945 0.0149 0.00911 0.0111 0.00921 0.0102 0.00805 0.0108 0.0102 0.00834 0.0109 0.00956 0.0119 0.0126 0.011 0.00987 0.0111 0.00938 0.00897 0.0106 0.01 0.0106 0.0114 0.0136 0.0109 0.00841 0.00836 0.00671 0.00991 0.00846 0.00738 0.00907 0.0129 0.0164 0.00967 0.00969 0.00959 3.02...3.05 0.00381 0.00328 0.0047 0.00524 0.00523 0.00437 0.00525 0.0065 0.00599 0.00359 0.00475 0.0052 0.00381 0.00416 0.00425 0.00481 0.0044 0.00575 0.00363 0.00513 0.00494 0.0064 0.00551 0.00352 0.00469 0.00568 0.00505 0.00488 0.00402 0.00388 0.00303 0.00415 0.00507 0.00426 0.00419 0.00584 0.00621 0.00466 0.00468 0.00469 3.05...3.10 0.00261 0.0026 0.00305 0.0034 0.00342 0.0031 0.00307 0.00373 0.00295 0.00237 0.00366 0.00323 0.00277 0.00395 0.00326 0.00409 0.00332 0.00372 0.0027 0.00642 0.0031 0.00254 0.00348 0.00318 0.00342 0.0644 0.00406 0.0701 0.0456 0.0034 0.00235 0.00358 0.00306 0.00267 0.00296 0.00351 0.00415 0.0182 0.0183 0.018 3.10...3.14 0.00163 0.00101 0.00141 0.00169 0.00245 0.00168 0.00185 0.00126 0.00195 0.00117 0.00176 0.00186 0.00119 0.00159 0.00111 0.0026 0.00201 0.00151 0.00191 0.00392 0.00114 0.0013 0.00136 0.00199 0.00163 0.0438 0.00338 0.0477 0.0329 0.00144 0.00119 0.00138 0.00137 0.00122 0.00171 0.00236 0.00289 0.012 0.0121 0.012 3.14...3.17 0.00224 0.00151 0.00223 0.00237 0.00314 0.00165 0.00296 0.00258 0.00262 0.0018 0.00261 0.0024 0.002 0.00259 0.00233 0.00275 0.00232 0.00273 0.00182 0.00369 0.00146 0.00212 0.002 0.00179 0.00202 0.0221 0.00273 0.0248 0.0558 0.00208 0.00174 0.00205 0.00283 0.00169 0.00122 0.00278 0.00283 0.00736 0.0075 0.00735 3.17...3.22 0.0485 0.0428 0.0704 0.0598 0.0286 0.0531 0.0621 0.0557 0.0597 0.0473 0.0463 0.0665 0.0506 0.0525 0.0594 0.0407 0.0388 0.0481 0.0321 0.048 0.0348 0.0243 0.0562 0.0363 0.0557 0.0747 0.0434 0.0692 0.0563 0.0351 0.0343 0.0507 0.0409 0.0334 0.039 0.0328 0.041 0.0425 0.0426 0.0414 3.22...3.27 0.0168 0.0232 0.0253 0.0221 0.0212 0.0165 0.0227 0.019 0.0164 0.0204 0.0198 0.0248 0.0191 0.0221 0.0219 0.0268 0.0355 0.0237 0.0209 0.0235 0.0231 0.0172 0.0267 0.0207 0.0208 0.0264 0.0261 0.025 0.0168 0.0174 0.015 0.022 0.0184 0.015 0.0314 0.0208 0.0297 0.0211 0.0214 0.0198 3.27...3.29 0.000952 0.00118 0.00147 0.00144 0.0021 0.00109 0.0011 0.00175 0.00131 0.00109 0.000951 0.00198 0.000882 0.0016 0.00127 0.00217 0.00294 0.00133 0.0014 0.00128 0.00109 0.000921 0.00149 0.00159 0.0016 0.00558 0.00183 0.00205 0.00158 0.00241 0.00094 0.00203 0.00143 0.00113 0.0019 0.00385 0.00302 0.00157 0.00176 0.00166 3.29...3.35 0.00335 0.00512 0.00579 0.00538 0.00473 0.00276 0.00678 0.00431 0.00377 0.00392 0.00427 0.00562 0.00377 0.00519 0.0046 0.00549 0.00711 0.00642 0.00396 0.00493 0.00319 0.00357 0.00443 0.00431 0.00416 0.00757 0.00697 0.00611 0.00623 0.00458 0.0038 0.00558 0.0045 0.00433 0.00493 0.0062 0.00615 0.00542 0.00545 0.00512 3.35...3.37 0.000513 0.000414 0.000611 0.000736 0.00135 0.001 0.000743 0.000465 0.000572 0.000491 0.00103 0.00078 0.000501 0.000881 0.000539 0.00175 0.00329 0.00081 0.00155 0.000887 0.000646 0.000711 0.000508 0.00124 0.000668 0.00117 0.00204 0.000852 0.000857 0.00102 0.000495 0.000533 0.000702 0.000492 0.000272 0.00147 0.00217 0.000789 0.000792 0.000897 3.37...3.42 0.0259 0.0365 0.0432 0.0364 0.0369 0.029 0.0384 0.0255 0.0281 0.031 0.037 0.0431 0.0327 0.0394 0.0401 0.0455 0.0578 0.0422 0.0375 0.0422 0.0446 0.0324 0.0431 0.0369 0.034 0.0315 0.0417 0.0309 0.0206 0.0311 0.0239 0.0323 0.0311 0.0214 0.0548 0.0281 0.0453 0.0349 0.0354 0.0341 3.42...3.47 0.0217 0.0289 0.0338 0.0287 0.028 0.0226 0.0309 0.0202 0.0217 0.0244 0.0286 0.0358 0.026 0.0308 0.0311 0.0353 0.0454 0.0327 0.0302 0.0331 0.0348 0.0259 0.0338 0.0295 0.027 0.0257 0.0332 0.0248 0.0173 0.0251 0.0187 0.0257 0.0252 0.0173 0.0441 0.0225 0.0348 0.0282 0.0284 0.0274 3.47...3.50 0.0107 0.0156 0.0181 0.0147 0.0169 0.011 0.016 0.011 0.0106 0.0127 0.014 0.0178 0.0134 0.0164 0.0164 0.0203 0.0261 0.0173 0.0185 0.0179 0.0195 0.0123 0.0193 0.0169 0.0146 0.0124 0.0214 0.012 0.00935 0.0119 0.0096 0.0128 0.0122 0.00852 0.0226 0.0111 0.0221 0.014 0.0143 0.0131 3.50...3.54 0.0147 0.0186 0.0207 0.0197 0.0204 0.0167 0.0211 0.0153 0.016 0.0151 0.0203 0.021 0.0176 0.021 0.0202 0.0206 0.0261 0.0212 0.0182 0.0221 0.0231 0.0163 0.0217 0.0183 0.0186 0.0206 0.0202 0.0162 0.0163 0.0161 0.0123 0.0183 0.0161 0.0125 0.0271 0.0179 0.0232 0.0181 0.0187 0.0184 3.54...3.60 0.011 0.0135 0.0125 0.0118 0.02 0.0119 0.0162 0.014 0.014 0.0106 0.0124 0.0125 0.00917 0.0126 0.0123 0.0134 0.0175 0.013 0.0132 0.0158 0.0109 0.00905 0.0114 0.0108 0.0124 0.0297 0.0186 0.0103 0.198 0.00977 0.00729 0.0109 0.00895 0.00793 0.0114 0.0128 0.0161 0.0117 0.012 0.0112 3.60...3.62 0.00265 0.00257 0.00205 0.00215 0.00369 0.00201 0.00256 0.00243 0.00218 0.0017 0.00221 0.00273 0.00224 0.00216 0.00198 0.00366 0.00293 0.00228 0.00316 0.00254 0.00191 0.00178 0.00214 0.00248 0.00238 0.00371 0.00457 0.00221 0.00594 0.00251 0.00137 0.0023 0.00212 0.00168 0.00214 0.00317 0.00327 0.00247 0.00259 0.00236 3.62...3.67 0.0203 0.0195 0.0193 0.0176 0.0311 0.0177 0.0266 0.0227 0.0193 0.0162 0.0198 0.022 0.0158 0.0183 0.019 0.0227 0.025 0.0192 0.0204 0.0246 0.0172 0.0144 0.0166 0.0162 0.0201 0.0166 0.0292 0.0148 0.0146 0.0159 0.0106 0.0174 0.0173 0.0128 0.015 0.0204 0.0264 0.0196 0.0194 0.0181 3.67...3.73 0.0342 0.0484 0.0535 0.0468 0.0508 0.0378 0.0475 0.0364 0.0376 0.0401 0.047 0.0514 0.0415 0.0497 0.0501 0.0543 0.0701 0.0532 0.047 0.0521 0.0547 0.039 0.0541 0.0443 0.0433 0.0415 0.0537 0.0385 0.0271 0.0385 0.0306 0.04 0.0371 0.0271 0.0633 0.0379 0.0568 0.0428 0.0434 0.0418 3.73...3.78 0.0165 0.0211 0.0238 0.0219 0.0228 0.0176 0.0225 0.0174 0.0178 0.0173 0.0206 0.0231 0.0198 0.024 0.0224 0.0228 0.0295 0.0241 0.0208 0.0254 0.0245 0.0183 0.0244 0.0197 0.0207 0.018 0.0238 0.0173 0.012 0.0158 0.0139 0.0204 0.0174 0.0138 0.0289 0.0169 0.0251 0.0202 0.0201 0.0198 3.78...3.80 0.00422 0.00535 0.00468 0.00513 0.00851 0.00468 0.0052 0.00532 0.00476 0.0039 0.00515 0.00469 0.00365 0.00494 0.00466 0.00606 0.00746 0.00524 0.00533 0.00597 0.0047 0.00364 0.00484 0.00435 0.0047 0.00418 0.00772 0.00386 0.00308 0.00372 0.00271 0.00399 0.00338 0.00328 0.00498 0.00486 0.00709 0.0045 0.00452 0.00429 3.80...3.85 0.0235 0.032 0.0356 0.03 0.0362 0.0259 0.0321 0.0235 0.0238 0.026 0.0307 0.0357 0.0269 0.0335 0.0339 0.038 0.0496 0.035 0.033 0.0368 0.0384 0.0272 0.0363 0.0319 0.0302 0.0269 0.0385 0.0263 0.0174 0.0262 0.02 0.0284 0.0259 0.0185 0.046 0.025 0.0408 0.0297 0.0306 0.0292 3.85...3.91 0.0303 0.0421 0.0432 0.037 0.0512 0.0311 0.0442 0.0326 0.0318 0.033 0.0379 0.0423 0.0323 0.0411 0.0416 0.045 0.0593 0.0433 0.0389 0.047 0.0437 0.0326 0.0434 0.0357 0.0382 0.0342 0.05 0.0328 0.0232 0.0316 0.0245 0.0356 0.0307 0.0239 0.0505 0.0343 0.0511 0.0368 0.038 0.036 3.91...3.94 0.00437 0.0061 0.00553 0.00614 0.00615 0.00498 0.00509 0.00731 0.00606 0.00439 0.00478 0.00543 0.00424 0.00447 0.00533 0.00407 0.00518 0.00612 0.004 0.00619 0.00573 0.0052 0.00614 0.00413 0.0059 0.00545 0.00573 0.00496 0.00417 0.0036 0.00309 0.0052 0.00466 0.00395 0.00667 0.00404 0.0053 0.00508 0.00561 0.00498 3.94...4.00 0.00346 0.00611 0.00563 0.00541 0.00785 0.00469 0.00454 0.00601 0.00433 0.00411 0.00335 0.00491 0.00359 0.00525 0.00509 0.00495 0.00917 0.00534 0.00536 0.0057 0.00475 0.00337 0.00587 0.00481 0.00573 0.00552 0.00714 0.00467 0.00354 0.00337 0.00344 0.0052 0.00379 0.00412 0.00859 0.00533 0.00798 0.00484 0.00559 0.00461 4.00...4.03 0.000778 0.00147 0.00107 0.000953 0.00105 0.000774 0.0000672 0.00129 0.000921 0.000739 0.000351 0.000778 0.000764 0.000935 0.000801 0.000923 0.0025 0.000829 0.000948 0.00111 0.00106 0.00061 0.00137 0.00122 0.00133 0.00121 0.00106 0.000767 0.000253 0.000734 0.000759 0.00121 0.000867 0.00144 0.00294 0.000782 0.00138 0.00104 0.00135 0.000884 4.03...4.08 0.00319 0.00381 0.00267 0.00356 0.00303 0.00249 0.00124 0.00463 0.00292 0.00271 0.00206 0.0027 0.00243 0.00348 0.00237 0.00321 0.00377 0.00277 0.00315 0.00358 0.00355 0.00349 0.00414 0.00452 0.00351 0.00296 0.00315 0.00235 0.000793 0.00319 0.0044 0.00419 0.00431 0.00477 0.00549 0.00359 0.00558 0.00345 0.00382 0.00329 4.08...4.14 0.0256 0.0113 0.0118 0.00826 0.0245 0.00905 0.0115 0.00883 0.00783 0.00822 0.0112 0.00913 0.0164 0.00724 0.00916 0.011 0.0125 0.0121 0.0199 0.0124 0.00821 0.00679 0.00759 0.0084 0.0121 0.00825 0.0123 0.011 0.0171 0.00888 0.00471 0.00949 0.00926 0.0131 0.0112 0.0354 0.011 0.0128 0.0131 0.0102 4.14...4.15 0.00114 0.000898 0.00108 0.000905 0.0028 0.00297 0.00215 0.00144 0.00158 0.000906 0.000664 0.00142 0.000775 0.000969 0.000843 0.000503 0.000997 0.000789 0.000829 0.0013 0.000728 0.000574 0.00128 0.00127 0.00137 0.000575 0.000793 0.00147 0.00049 0.000606 0.000575 0.00094 0.000663 0.000718 0.00142 0.00185 0.00114 0.000994 0.00113 0.00103 5.15...5.17 0.000772 0.000627 0.000756 0.000475 0.000122 0.000885 0.000402 0.000307 0.000652 0.000718 0.000959 0.000712 0.000541 0.000443 0.000767 0.000874 0.00063 0.000802 0.000769 0.000596 0.000887 0.00111 0.00043 0.000453 0.000382 0.000454 0.000664 0.000456 0.000139 0.000973 0.000516 0.000233 0.000447 0.000389 0.0000318 0.000732 0.000998 0.00056 0.000375 0.000715 5.17...5.20 0.00165 0.00126 0.000593 0.000809 0.000242 0.00141 0.000677 0.00102 0.00118 0.00153 0.00144 0.00107 0.00141 0.000811 0.00113 0.00128 0.000679 0.000941 0.00112 0.000643 0.00146 0.00246 0.000483 0.00141 0.000659 0.000718 0.00102 0.000716 0.000368 0.00257 0.00263 0.00106 0.00201 0.002 0.000387 0.00124 0.00104 0.00114 0.000837 0.00141 5.20...5.23 0.00965 0.0122 0.0144 0.013 0.0114 0.0113 0.0123 0.00914 0.0104 0.0109 0.013 0.0138 0.0117 0.0142 0.0147 0.0142 0.0181 0.0141 0.0123 0.0138 0.0151 0.0129 0.0138 0.0136 0.0119 0.0102 0.0128 0.00981 0.00629 0.0118 0.00925 0.0119 0.0108 0.00804 0.0185 0.00913 0.015 0.0115 0.0117 0.0124 5.23...5.25 0.00393 0.00359 0.00446 0.00441 0.000508 0.00481 0.00385 0.00432 0.00426 0.00397 0.00363 0.00398 0.00388 0.00408 0.00457 0.00247 0.00151 0.00345 0.00245 0.00299 0.00339 0.00314 0.00351 0.00258 0.00474 0.0013 0.00164 0.00131 0.000594 0.00361 0.00344 0.00399 0.00309 0.00324 0.00296 0.00145 0.00199 0.00303 0.00282 0.0033 5.25...5.31 0.0176 0.0178 0.0144 0.0199 0.00347 0.0229 0.0129 0.02 0.0189 0.0213 0.0167 0.014 0.02 0.0178 0.0184 0.0114 0.00663 0.014 0.0123 0.0127 0.0205 0.0233 0.0158 0.0189 0.019 0.0059 0.00815 0.00701 0.00436 0.0258 0.0319 0.0227 0.0234 0.0293 0.0165 0.00952 0.00797 0.0153 0.0153 0.0184 5.31...5.37 0.00433 0.00462 0.00236 0.0043 0.000793 0.00418 0.000734 0.0045 0.00472 0.0063 0.00369 0.00255 0.00536 0.00371 0.00379 0.00336 0.00264 0.00266 0.00506 0.00175 0.00418 0.0102 0.00288 0.007 0.00282 0.00174 0.00245 0.002 0.00174 0.00844 0.011 0.00489 0.00616 0.00884 0.00361 0.00482 0.00293 0.0044 0.00402 0.00536 5.37...5.40 0.000698 0.000736 0.000557 0.000428 0.0000387 0.000453 0 0.000391 0.000523 0.000803 0.000469 0.000527 0.000667 0.000297 0.000755 0.000437 0.000765 0.000365 0.000865 0.000176 0.000477 0.00113 0.000426 0.000638 0.000282 0.000569 0.000566 0.000332 0.0000399 0.000843 0.000744 0.000465 0.000366 0.000517 0.000434 0.000721 0.000901 0.000618 0.00044 0.000674 6.80...6.82 0.000191 0.000259 0.000217 0.000232 0.00017 0.000244 0.00000555 0.000169 0.000308 0.00018 0.000195 0.000316 0.00024 0.000189 0.000369 0.000241 0.000407 0.000237 0.000611 0.000271 0.000218 0.000259 0.000312 0.000382 0.000239 0.0002 0.00044 0.000206 0.000084 0.0003 0.000146 0.000115 0.000177 0.000197 0.000272 0.000281 0.000528 0.000289 0.000214 0.00032 6.82...6.84 0.00029 0.000245 0.000327 0.000133 0.000855 0.000184 0 0.000217 0.000187 0.000152 0.000175 0.000346 0.000205 0.000175 0.000212 0.000872 0.000918 0.000233 0.000977 0.000299 0.00025 0.000264 0.000293 0.000667 0.000273 0.000246 0.000645 0.000169 0.000095 0.00036 0.000178 0.000151 0.000193 0.000143 0.000385 0.000364 0.00117 0.000235 0.000245 0.000314 6.84...6.89 0.00107 0.00151 0.0018 0.00145 0.000648 0.00108 0.000628 0.00134 0.00248 0.00154 0.00172 0.00183 0.00171 0.00149 0.00169 0.000978 0.000732 0.00183 0.000841 0.00158 0.0011 0.00135 0.00155 0.000563 0.00133 0.00126 0.000778 0.000908 0.000519 0.00131 0.000925 0.00119 0.0012 0.00102 0.00093 0.00121 0.0012 0.00148 0.00131 0.00135 6.89...6.91 0.000348 0.000374 0.000366 0.000368 0.000328 0.000383 0.0000428 0.000742 0.000339 0.000202 0.000413 0.000396 0.000235 0.000143 0.000361 0.000374 0.000419 0.000323 0.00032 0.000331 0.00028 0.000351 0.000317 0.00036 0.000293 0.000304 0.000394 0.000224 0.000149 0.000305 0.000216 0.000182 0.000226 0.000201 0.000256 0.00035 0.000611 0.000318 0.000297 0.000265 6.91...6.97 0.00118 0.0011 0.00139 0.00106 0.00102 0.000964 0.000552 0.000971 0.000986 0.00085 0.00107 0.00156 0.000803 0.00104 0.00119 0.00147 0.00145 0.0012 0.00112 0.00117 0.00138 0.00108 0.00125 0.00127 0.00123 0.00121 0.00163 0.00107 0.000473 0.00124 0.000768 0.0012 0.000965 0.000869 0.00132 0.00153 0.00207 0.00134 0.00114 0.00128 6.97...6.99 0.000305 0.000349 0.000446 0.000319 0.000492 0.000426 0.0000163 0.000364 0.000355 0.000258 0.000335 0.000465 0.00026 0.000311 0.000468 0.000705 0.000733 0.000473 0.000605 0.000291 0.000347 0.000278 0.000465 0.000487 0.000291 0.000249 0.000823 0.000212 0.000113 0.00019 0.000235 0.000206 0.000176 0.000212 0.000345 0.00023 0.00107 0.000299 0.000269 0.00031 6.99...7.05 0.00104 0.00126 0.0011 0.000806 0.000549 0.000961 0.000309 0.00101 0.00087 0.000773 0.000933 0.00128 0.000876 0.00108 0.00116 0.000591 0.000729 0.00117 0.000613 0.00102 0.000991 0.000929 0.00118 0.000585 0.000928 0.00111 0.000713 0.000815 0.0004 0.00101 0.000605 0.000915 0.000823 0.00081 0.001 0.00107 0.000881 0.00104 0.000913 0.00108 7.05...7.08 0.000326 0.000335 0.000374 0.000425 0.000322 0.000361 0 0.000265 0.000379 0.000305 0.000234 0.000461 0.000222 0.000352 0.000354 0.000427 0.000402 0.00042 0.000371 0.000403 0.000412 0.000413 0.000214 0.000384 0.000343 0.000373 0.000422 0.000317 0.000066 0.000327 0.000254 0.000269 0.000203 0.000207 0.000363 0.000351 0.000588 0.000408 0.00026 0.000421 7.08...7.10 0.000231 0.000289 0.000249 0.000255 0.000204 0.000217 0 0.00019 0.000216 0.000165 0.000128 0.000236 0.000172 0.00026 0.000305 0.000242 0.000403 0.000263 0.000165 0.000245 0.000157 0.000248 0.000315 0.000171 0.000215 0.000207 0.000262 0.000185 0.0000917 0.000233 0.00011 0.000192 0.000173 0.000154 0.000278 0.000258 0.000522 0.000263 0.000233 0.000286 7.10...7.13 0.000257 0.000303 0.000286 0.000226 0.000235 0.000167 0 0.000136 0.000168 0.000203 0.000152 0.000238 0.000142 0.000207 0.000272 0.000239 0.000285 0.000188 0.000288 0.000169 0.000229 0.000231 0.000275 0.00025 0.000241 0.000214 0.000217 0.0000693 0.0000802 0.000266 0.000147 0.000117 0.000146 0.000135 0.000279 0.000227 0.000461 0.00028 0.00019 0.000275 7.13...7.18 0.00108 0.00155 0.00183 0.00145 0.00104 0.00111 0.000272 0.00122 0.00264 0.00155 0.0017 0.00164 0.00166 0.0015 0.00163 0.00143 0.00144 0.0017 0.00164 0.00124 0.000866 0.00123 0.00134 0.000909 0.0012 0.00128 0.00109 0.000927 0.000456 0.0011 0.000929 0.00109 0.000951 0.00103 0.000996 0.00112 0.00185 0.0014 0.00125 0.00133 7.18...7.21 0.000362 0.000453 0.000541 0.000332 0.000491 0.000446 0.000148 0.000386 0.00042 0.000297 0.000383 0.00043 0.000366 0.000282 0.000441 0.00065 0.000554 0.00044 0.000478 0.000491 0.00037 0.000468 0.000441 0.000388 0.000454 0.000475 0.000538 0.000416 0.000132 0.000399 0.000212 0.000385 0.000295 0.000322 0.000452 0.000397 0.000802 0.000407 0.000322 0.000427 7.21...7.26 0.000877 0.00106 0.000905 0.000789 0.00126 0.00089 0.000261 0.000899 0.000931 0.000742 0.00071 0.000811 0.000657 0.000743 0.00104 0.00147 0.00127 0.000943 0.00099 0.00108 0.000666 0.000886 0.000949 0.00101 0.00116 0.00101 0.00143 0.000962 0.000644 0.000832 0.000599 0.000708 0.000855 0.000614 0.00116 0.0011 0.00157 0.000977 0.000889 0.000925 7.26...7.32 0.00104 0.00101 0.00106 0.000907 0.00111 0.00111 0.000386 0.000952 0.00133 0.00104 0.000886 0.00109 0.000732 0.00077 0.00101 0.00121 0.00127 0.00102 0.00111 0.00112 0.000832 0.000985 0.000996 0.00101 0.00107 0.000936 0.00134 0.000779 0.00059 0.000869 0.000592 0.000855 0.000769 0.000708 0.00116 0.000991 0.00175 0.00104 0.00101 0.00095 7.32...7.37 0.000635 0.000786 0.000749 0.000664 0.000623 0.000748 0 0.000729 0.000762 0.000563 0.000581 0.000672 0.000526 0.000647 0.0008 0.000917 0.000923 0.000779 0.000861 0.00086 0.000758 0.000559 0.00051 0.000764 0.000853 0.000731 0.000953 0.000412 0.000413 0.000619 0.000405 0.000398 0.000629 0.00045 0.000895 0.000891 0.0014 0.000735 0.000612 0.000756 7.37...7.42 0.000347 0.000369 0.000425 0.000289 0 0.000372 0 0.000326 0.000434 0.000292 0.000311 0.000495 0.000311 0.000366 0.000393 0.00051 0.000434 0.000495 0.000417 0.000333 0.000358 0.000336 0.000207 0.000377 0.000393 0.00037 0.000431 0.000147 0 0.000405 0.000282 0.000231 0.000281 0.000293 0.000423 0.00026 0.000567 0.000381 0.00022 0.000431 7.42...7.46 0.000452 0.000409 0.000364 0.000301 0.0000507 0.000343 0 0.000287 0.000275 0.0002 0.000131 0.000269 0.000283 0.000268 0.000265 0.000262 0.000518 0.000184 0.000352 0.00027 0.000386 0.000259 0.000345 0.000369 0.000251 0.00029 0.000397 0.000136 0 0.000329 0.0000827 0.000215 0.000122 0.000194 0.00038 0.000405 0.000585 0.00042 0.000233 0.0004 7.46...7.48 0.000176 0.000199 0.0000866 0.000174 0.000123 0.000132 0 0.000118 0.000159 0.000105 0.0000603 0.000167 0.000153 0.0000224 0.0001 0.000193 0.000282 0.000135 0.000244 0.000168 0.000203 0.000137 0.00013 0.000183 0.000103 0.000104 0.000181 0.0000522 0 0.000193 0.0000875 0.0000314 0.0000831 0.000104 0.000186 0.000174 0.000313 0.000149 0.000102 0.000141 7.48...7.53 0.00088 0.000751 0.00102 0.000734 0.000629 0.000325 0.000155 0.000587 0.00067 0.00064 0.000697 0.00101 0.000668 0.000768 0.000902 0.0009 0.000959 0.000792 0.000783 0.000722 0.000833 0.000826 0.00096 0.000972 0.000947 0.000528 0.00113 0.000236 0 0.000817 0.0006 0.000955 0.000579 0.000583 0.001 0.00111 0.00145 0.000825 0.000781 0.000878 7.53...7.59 0.000508 0.000506 0.00059 0.000376 0.000548 0.000859 0.00000337 0.000618 0.000599 0.000461 0.000518 0.000735 0.000421 0.000315 0.000532 0.000412 0.000723 0.0004 0.000485 0.000547 0.000639 0.000431 0.000709 0.00053 0.000502 0.000869 0.00062 0.00078 0.000208 0.000439 0.000368 0.000429 0.000381 0.00035 0.00054 0.000735 0.000996 0.000691 0.00057 0.00047 7.59...7.61 0.000249 0.000181 0.00022 0.000174 0.000181 0.000265 0 0.000181 0.000179 0.000118 0.00023 0.000296 0.000168 0.000185 0.000247 0.00033 0.000371 0.000186 0.000458 0.000285 0.000214 0.000154 0.000235 0.000428 0.000164 0.000334 0.000488 0.000165 0.0000602 0.000252 0.000172 0.000152 0.0000609 0.000123 0.000173 0.000353 0.000408 0.00025 0.000259 0.000203 7.61...7.63 0.000242 0.00022 0.000238 0.000209 0.000366 0.000184 0.0000378 0.000254 0.000199 0.000148 0.000173 0.000396 0.000157 0.000148 0.000351 0.000553 0.000559 0.000161 0.000451 0.000223 0.000251 0.000297 0.000154 0.000414 0.000202 0.000296 0.000538 0.0002 0.0000339 0.000309 0.0000925 0.000165 0.000416 0.000176 0.000246 0.000384 0.000834 0.000335 0.000281 0.000267 7.63...7.69 0.00169 0.00135 0.00166 0.00126 0.00258 0.000762 0.00135 0.00168 0.00135 0.00125 0.00142 0.002 0.00113 0.00167 0.00159 0.00228 0.00244 0.00159 0.00204 0.00197 0.00176 0.00166 0.0019 0.00193 0.00192 0.00214 0.00258 0.00174 0.000768 0.00168 0.00118 0.00158 0.00145 0.00117 0.00184 0.00224 0.0032 0.0019 0.00186 0.0019 7.69...7.73 0.00085 0.0011 0.00124 0.000905 0.000636 0.00132 0.000434 0.00102 0.000843 0.000768 0.00105 0.000983 0.000914 0.000957 0.00113 0.000715 0.000913 0.00115 0.000832 0.000907 0.000966 0.000799 0.0012 0.00062 0.000894 0.00094 0.000958 0.000754 0.000651 0.000767 0.000661 0.000842 0.000662 0.000715 0.000896 0.000835 0.00113 0.000827 0.000878 0.00096 7.73...7.75 0.000308 0.00021 0.000255 0.000204 0.000287 0.000256 0 0.000219 0.000187 0.000201 0.000204 0.000308 0.000162 0.000207 0.000172 0.000381 0.000413 0.000204 0.000388 0.000266 0.00017 0.0003 0.000257 0.00038 0.000241 0.000263 0.000413 0.000227 0 0.000289 0.000141 0.000171 0.000148 0.000179 0.00033 0.000343 0.000569 0.000265 0.000295 0.000267 NMR_BINNED_DATA_END #END