#METABOLOMICS WORKBENCH jgooding_20170227_142647 DATATRACK_ID:855 STUDY_ID:ST000565 ANALYSIS_ID:AN000868 PROJECT_ID:PR000415
VERSION             	1
CREATED_ON             	March 6, 2017, 11:44 am
#PROJECT
PR:PROJECT_TITLE                 	Association of hemodialysis patient plasma trace metals with response to
PR:PROJECT_TITLE                 	erythropoiesis stimulating agents
PR:PROJECT_TYPE                  	Metallomics
PR:PROJECT_SUMMARY               	Erythropoietin (EPO) is a cytokine used to treat the anemia of chronic renal
PR:PROJECT_SUMMARY               	disease in greater than 90% of all in-center hemodialysis patients at a cost of
PR:PROJECT_SUMMARY               	approximately 2 billion dollars per year (2010). Despite protocols for anemia
PR:PROJECT_SUMMARY               	management in the end stage kidney disease (ESKD) population, a large proportion
PR:PROJECT_SUMMARY               	of patients do not predictably respond to typical doses of EPO. Several recent
PR:PROJECT_SUMMARY               	randomized controlled trials looking to increase hemoglobin in patients with the
PR:PROJECT_SUMMARY               	anemia of renal disease have uncovered many questions about the treatment of
PR:PROJECT_SUMMARY               	anemia with erythropoietic stimulating agents (ESA) not previously addressed in
PR:PROJECT_SUMMARY               	new drug applications or in subsequent research. We sought to test the
PR:PROJECT_SUMMARY               	hypothesis that serum trace metal concentrations correlate with markers of
PR:PROJECT_SUMMARY               	anemia and response to ESA treatment. EDTA-Plasma from 110 hemodialysis patients
PR:PROJECT_SUMMARY               	participating in an NIDDK funded study (R01-01DK091584) were analyzed by ICP-MS
PR:PROJECT_SUMMARY               	for the concentration of As, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sb, Se, Sn, V, and
PR:PROJECT_SUMMARY               	Zn. Associations were determined between trace metals and gender, race,
PR:PROJECT_SUMMARY               	hemodialysis status, hemoglobin at the time of draw (Hgb), total ESA dose for
PR:PROJECT_SUMMARY               	the month the sample was collected (EPO), and erythropoietin resistance index
PR:PROJECT_SUMMARY               	determined over the 6 months of treatment leading up to sample collection (ERI).
PR:INSTITUTE                     	University of Louisville
PR:DEPARTMENT                    	School of Medicine, Division of Nephrology & Hypertension
PR:LAST_NAME                     	Merchant
PR:FIRST_NAME                    	Michael
PR:ADDRESS                       	550 South Jackson Street, 3rd Floor, Louisville, Kentucky 40202
PR:EMAIL                         	michael.merchant@louisville.edu
PR:PHONE                         	502/852-0245
PR:FUNDING_SOURCE                	NIH Grants 1R01DK091584, U24DK097193, and K01GM109320
#STUDY
ST:STUDY_TITLE                   	Association of hemodialysis patient plasma trace metals with response to
ST:STUDY_TITLE                   	erythropoiesis stimulating agents
ST:STUDY_TYPE                    	Metallomics
ST:STUDY_SUMMARY                 	EDTA-Plasma from 110 hemodialysis patients participating in an NIDDK funded
ST:STUDY_SUMMARY                 	study were analyzed by ICP-MS for the concentration of As, Cd, Co, Cr, Cu, Mn,
ST:STUDY_SUMMARY                 	Mo, Ni, Pb, Sb, Se, Sn, V, and Zn. Associations were determined between trace
ST:STUDY_SUMMARY                 	metals and gender, race, hemodialysis status, hemoglobin at the time of draw
ST:STUDY_SUMMARY                 	(Hgb), total ESA dose for the month the sample was collected (EPO), and
ST:STUDY_SUMMARY                 	erythropoietin resistance index determined over the 6 months of treatment
ST:STUDY_SUMMARY                 	leading up to sample collection (ERI)
ST:INSTITUTE                     	RTI International
ST:LABORATORY                    	NIH Eastern Regional Comprehensive Metabolomics Resource Core at UNC Chapel Hill
ST:LABORATORY                    	(ERCMRC)
ST:LAST_NAME                     	Sumner
ST:FIRST_NAME                    	Susan
ST:ADDRESS                       	3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA
ST:EMAIL                         	susan_sumner@unc.edu
ST:PHONE                         	704-250-5000
ST:TOTAL_SUBJECTS                	110
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Both
SU:HUMAN_TRIAL_TYPE              	validation/discovery trial
SU:HUMAN_INCLUSION_CRITERIA      	All subjects will receive hemodialysis in-center on a 3 times per week dialysis
SU:HUMAN_INCLUSION_CRITERIA      	schedule. Subjects are eligible to participate if 1) subjects that have received
SU:HUMAN_INCLUSION_CRITERIA      	EPO will have received it for 6 or more months, 2) between the ages of 18 and 80
SU:HUMAN_INCLUSION_CRITERIA      	years, 3) have an adequacy of dialysis (Kt/V) that is ≥ 1.2, 4) have adequate
SU:HUMAN_INCLUSION_CRITERIA      	iron stores as measured by ferritin and transferrin saturation.
SU:HUMAN_EXCLUSION_CRITERIA      	None
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	-	M1	Gender:F | Race:Caucasian	Months on dialysis=14; EPO=14000; ERI=1.69; Hb=11.9; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M10	Gender:M | Race:Other	Months on dialysis=96; EPO=29200; ERI=3.96; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M100	Gender:M | Race:African American	Months on dialysis=29; EPO=25400; ERI=2.98; Hb=9.6; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M101	Gender:F | Race:Other	Months on dialysis=32; EPO=88500; ERI=4; Hb=10.1; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M102	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=10.2; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M103	Gender:M | Race:Caucasian	Months on dialysis=37; EPO=26000; ERI=2.25; Hb=11.1; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M104	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=11.8; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M105	Gender:F | Race:Caucasian	Months on dialysis=101; EPO=115500; ERI=9.1; Hb=7.3; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M106	Gender:F | Race:Caucasian	Months on dialysis=10; EPO=132000; ERI=7.55; Hb=10; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M107	Gender:F | Race:Caucasian	Months on dialysis=49; EPO=87100; ERI=7.47; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M109	Gender:M | Race:Caucasian	Months on dialysis=6; EPO=10000; ERI=2.6; Hb=7.9; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M11	Gender:M | Race:Caucasian	Months on dialysis=6; EPO=-; ERI=-; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M110	Gender:M | Race:African American	Months on dialysis=2; EPO=1000; ERI=0.02; Hb=9.5; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M111	Gender:M | Race:Caucasian	Months on dialysis=41; EPO=89500; ERI=7.64; Hb=8.7; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M112	Gender:M | Race:Caucasian	Months on dialysis=6; EPO=30000; ERI=0.74; Hb=12.6; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M113	Gender:M | Race:Other	Months on dialysis=67; EPO=28800; ERI=1.66; Hb=10.6; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M114	Gender:F | Race:Other	Months on dialysis=13; EPO=75300; ERI=5.19; Hb=10.3; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M115	Gender:M | Race:Caucasian	Months on dialysis=19; EPO=-; ERI=2.36; Hb=11.4; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M12	Gender:M | Race:Caucasian	Months on dialysis=2; EPO=-; ERI=-; Hb=11.8; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M13	Gender:M | Race:Other	Months on dialysis=1; EPO=6000; ERI=0.26; Hb=7.7; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M14	Gender:M | Race:Caucasian	Months on dialysis=41; EPO=3200; ERI=1.09; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M15	Gender:F | Race:Caucasian	Months on dialysis=23; EPO=106500; ERI=6.95; Hb=11.1; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M16	Gender:M | Race:African American	Months on dialysis=8; EPO=14000; ERI=4.14; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M17	Gender:M | Race:Caucasian	Months on dialysis=30; EPO=56000; ERI=9.46; Hb=10.9; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M18	Gender:M | Race:Other	Months on dialysis=12; EPO=-; ERI=-; Hb=11.8; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M19	Gender:M | Race:African American	Months on dialysis=12; EPO=-; ERI=-; Hb=13.3; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M2	Gender:M | Race:Caucasian	Months on dialysis=48; EPO=39800; ERI=3.83; Hb=8.9; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M20	Gender:Pool | Race:Pool	Months on dialysis=Pool; EPO=Pool; ERI=Pool; Hb=Pool; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M21	Gender:M | Race:Other	Months on dialysis=31; EPO=18900; ERI=2.21; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M22	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=8.3; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M23	Gender:M | Race:Other	Months on dialysis=58; EPO=37500; ERI=1.89; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M24	Gender:M | Race:African American	Months on dialysis=1; EPO=5000; ERI=0.2; Hb=8.5; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M25	Gender:M | Race:Caucasian	Months on dialysis=46; EPO=26900; ERI=2.6; Hb=10.8; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M26	Gender:F | Race:Caucasian	Months on dialysis=36; EPO=35000; ERI=2.77; Hb=11.2; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M27	Gender:M | Race:Caucasian	Months on dialysis=8; EPO=-; ERI=1.24; Hb=11.6; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M28	Gender:F | Race:Other	Months on dialysis=36; EPO=34000; ERI=2.14; Hb=10.3; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M29	Gender:M | Race:Caucasian	Months on dialysis=9; EPO=22500; ERI=1.36; Hb=12.4; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M3	Gender:F | Race:Caucasian	Months on dialysis=10; EPO=4000; ERI=2.26; Hb=11.3; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M30	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=9.1; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M31	Gender:M | Race:Caucasian	Months on dialysis=46; EPO=-; ERI=0.19; Hb=12.4; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M32	Gender:M | Race:African American	Months on dialysis=6; EPO=-; ERI=-; Hb=12.6; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M33	Gender:F | Race:African American	Months on dialysis=1; EPO=-; ERI=-; Hb=9.9; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M34	Gender:F | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=-; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M35	Gender:F | Race:Caucasian	Months on dialysis=90; EPO=77000; ERI=6.86; Hb=10.4; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M36	Gender:M | Race:Other	Months on dialysis=11; EPO=12400; ERI=5.36; Hb=11.9; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M37	Gender:M | Race:Caucasian	Months on dialysis=49; EPO=39200; ERI=2.4; Hb=10.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M38	Gender:F | Race:Caucasian	Months on dialysis=42; EPO=3000; ERI=0.05; Hb=10.5; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M39	Gender:F | Race:Caucasian	Months on dialysis=50; EPO=11700; ERI=1.21; Hb=10.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M4	Gender:F | Race:Caucasian	Months on dialysis=26; EPO=58500; ERI=4.95; Hb=10.8; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M40	Gender:M | Race:Caucasian	Months on dialysis=14; EPO=30000; ERI=4.8; Hb=8.9; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M41	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=9.9; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M42	Gender:M | Race:Caucasian	Months on dialysis=197; EPO=17600; ERI=1.52; Hb=10.5; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M43	Gender:M | Race:Other	Months on dialysis=2; EPO=-; ERI=-; Hb=11.4; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M44	Gender:F | Race:Caucasian	Months on dialysis=16; EPO=-; ERI=5.53; Hb=9.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M45	Gender:F | Race:Caucasian	Months on dialysis=21; EPO=57600; ERI=4.74; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M46	Gender:M | Race:Caucasian	Months on dialysis=35; EPO=-; ERI=-; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M47	Gender:F | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=-; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M48	Gender:M | Race:African American	Months on dialysis=1; EPO=-; ERI=-; Hb=8.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M49	Gender:M | Race:Caucasian	Months on dialysis=50; EPO=1800; ERI=0.43; Hb=11.2; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M5	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=13.2; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M50	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M51	Gender:M | Race:Caucasian	Months on dialysis=34; EPO=69000; ERI=4.42; Hb=9.7; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M52	Gender:F | Race:Caucasian	Months on dialysis=56; EPO=18000; ERI=2.21; Hb=11.7; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M53	Gender:M | Race:Caucasian	Months on dialysis=24; EPO=26300; ERI=5.49; Hb=10.8; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M54	Gender:M | Race:Caucasian	Months on dialysis=7; EPO=110000; ERI=11.81; Hb=10.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M55	Gender:F | Race:Caucasian	Months on dialysis=15; EPO=78000; ERI=5.77; Hb=10.6; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M56	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=9.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M57	Gender:M | Race:African American	Months on dialysis=9; EPO=12000; ERI=1.29; Hb=10.3; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M58	Gender:F | Race:Caucasian	Months on dialysis=23; EPO=-; ERI=0.83; Hb=11.3; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M6	Gender:M | Race:Caucasian	Months on dialysis=68; EPO=1300; ERI=1.93; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M61	Gender:F | Race:Caucasian	Months on dialysis=50; EPO=30000; ERI=6.89; Hb=7.4; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M62	Gender:M | Race:Other	Months on dialysis=98; EPO=40000; ERI=3.03; Hb=10.8; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M63	Gender:M | Race:Caucasian	Months on dialysis=11; EPO=-; ERI=-; Hb=12; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M64	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=9.1; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M65	Gender:F | Race:Caucasian	Months on dialysis=6; EPO=24000; ERI=0.37; Hb=11.3; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M66	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=11.7; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M67	Gender:M | Race:Caucasian	Months on dialysis=44; EPO=5600; ERI=0.84; Hb=11.6; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M68	Gender:M | Race:Caucasian	Months on dialysis=36; EPO=-; ERI=-; Hb=9.4; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M69	Gender:M | Race:Other	Months on dialysis=68; EPO=130000; ERI=8.48; Hb=11.7; Raw Data Folder and Date of Analysis=Merchant_011116C
SUBJECT_SAMPLE_FACTORS           	-	M7	Gender:F | Race:African American	Months on dialysis=2; EPO=-; ERI=-; Hb=11.9; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M70	Gender:M | Race:Caucasian	Months on dialysis=2; EPO=-; ERI=-; Hb=15.2; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M71	Gender:M | Race:Caucasian	Months on dialysis=37; EPO=15100; ERI=1.41; Hb=9.1; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M72	Gender:F | Race:African American	Months on dialysis=1; EPO=6000; ERI=0.25; Hb=8.8; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M73	Gender:M | Race:Caucasian	Months on dialysis=33; EPO=64400; ERI=4.11; Hb=10.7; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M74	Gender:F | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=10.6; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M75	Gender:M | Race:African American	Months on dialysis=63; EPO=-; ERI=-; Hb=14.7; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M76	Gender:F | Race:African American	Months on dialysis=29; EPO=72000; ERI=4.33; Hb=10.8; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M77	Gender:F | Race:Caucasian	Months on dialysis=49; EPO=53400; ERI=3.73; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M78	Gender:F | Race:Caucasian	Months on dialysis=18; EPO=58000; ERI=9.61; Hb=9.2; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M79	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=10.3; Raw Data Folder and Date of Analysis=Merchant_011316
SUBJECT_SAMPLE_FACTORS           	-	M8	Gender:M | Race:African American	Months on dialysis=4; EPO=11000; ERI=2.55; Hb=9.8; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M80	Gender:F | Race:Caucasian	Months on dialysis=20; EPO=124800; ERI=8.39; Hb=10.9; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M81	Gender:F | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=11.2; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M82	Gender:M | Race:African American	Months on dialysis=26; EPO=19500; ERI=1.37; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M83	Gender:M | Race:Caucasian	Months on dialysis=12; EPO=70100; ERI=7.36; Hb=10.5; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M84	Gender:F | Race:Caucasian	Months on dialysis=48; EPO=15300; ERI=3.79; Hb=9.1; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M85	Gender:F | Race:Caucasian	Months on dialysis=92; EPO=71000; ERI=6.88; Hb=12.3; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M86	Gender:F | Race:Other	Months on dialysis=19; EPO=11100; ERI=1.2; Hb=11.5; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M87	Gender:F | Race:-	Months on dialysis=34; EPO=21600; ERI=1.91; Hb=12.4; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M88	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=11.2; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M89	Gender:M | Race:Other	Months on dialysis=1; EPO=-; ERI=-; Hb=-; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M9	Gender:M | Race:Other	Months on dialysis=14; EPO=10000; ERI=0.89; Hb=10.8; Raw Data Folder and Date of Analysis=Merchant_010616B
SUBJECT_SAMPLE_FACTORS           	-	M90	Gender:M | Race:Caucasian	Months on dialysis=61; EPO=11600; ERI=1.89; Hb=10.9; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M91	Gender:F | Race:Caucasian	Months on dialysis=3; EPO=60000; ERI=2.53; Hb=8.7; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M92	Gender:F | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=11.3; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M93	Gender:M | Race:Caucasian	Months on dialysis=38; EPO=130000; ERI=8.69; Hb=8.5; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M94	Gender:F | Race:Caucasian	Months on dialysis=115; EPO=120000; ERI=6.68; Hb=-; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M95	Gender:F | Race:Caucasian	Months on dialysis=29; EPO=25000; ERI=2.25; Hb=8.1; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M96	Gender:M | Race:Caucasian	Months on dialysis=1; EPO=-; ERI=-; Hb=11; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M97	Gender:M | Race:Caucasian	Months on dialysis=15; EPO=72000; ERI=10.4; Hb=11.3; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M98	Gender:F | Race:Caucasian	Months on dialysis=47; EPO=136200; ERI=9.93; Hb=10.9; Raw Data Folder and Date of Analysis=Merchant_011916
SUBJECT_SAMPLE_FACTORS           	-	M99	Gender:Pool | Race:Pool	Months on dialysis=Pool; EPO=Pool; ERI=Pool; Hb=Pool; Raw Data Folder and Date of Analysis=Merchant_011916
#COLLECTION
CO:COLLECTION_SUMMARY            	Subjects that passed the screening were asked to donate 20 mL of blood for
CO:COLLECTION_SUMMARY            	analysis following an informed consent process. The blood was processed to
CO:COLLECTION_SUMMARY            	plasma and serum and stored as 0.5mL aliquots at -70 degrees until analyzed.
CO:SAMPLE_TYPE                   	Blood
CO:ADDITIVES                     	EDTA
CO:BLOOD_SERUM_OR_PLASMA         	Plasma
#TREATMENT
TR:TREATMENT_SUMMARY             	NA
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	A volume of 150 µL of each EDTA-plasma sample was dispensed into an acid-washed
SP:SAMPLEPREP_SUMMARY            	plastic digestion tube. To each digestion vessel, 300 µL of concentrated HNO3,
SP:SAMPLEPREP_SUMMARY            	150 µL of concentrated HCl, and 100 µL of H2O2 solution was added. Samples
SP:SAMPLEPREP_SUMMARY            	were loosely capped and placed in the graphite digestion block and heated at a
SP:SAMPLEPREP_SUMMARY            	temperature of 90 °C for 2 hours. At the end of digestion, all samples were
SP:SAMPLEPREP_SUMMARY            	removed from the heating block and allowed to cool to room temperature. In the
SP:SAMPLEPREP_SUMMARY            	clean hood, samples were spiked with a multielement internal standard to provide
SP:SAMPLEPREP_SUMMARY            	a final concentration of 1.0 ng/mL Sc, In, and Pr, and diluted to the final
SP:SAMPLEPREP_SUMMARY            	volume with deionized (DI) H2O.
SP:PROCESSING_METHOD             	Acid Digestion
SP:PROCESSING_STORAGE_CONDITIONS 	90°C
SP:EXTRACT_STORAGE               	8°C
SP:SAMPLE_SPIKING                	Sc, In, Pr
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	None
CH:INSTRUMENT_NAME               	Thermo Element 2 ICP-MS
CH:COLUMN_NAME                   	None
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
AN:LABORATORY_NAME               	RTI
AN:OPERATOR_NAME                 	James Harrington
AN:SOFTWARE_VERSION              	Element ICP-MS, Version 3.1.2.242
AN:ACQUISITION_DATE              	1/6/16, 1/11/16, 1/13/16, and 1/19/16
#MS
MS:MS_COMMENTS                   	-
MS:INSTRUMENT_NAME               	Thermo Element 2 ICP
MS:INSTRUMENT_TYPE               	Sector Field
MS:MS_TYPE                       	Other
MS:ION_MODE                      	POSITIVE
MS:MASS_ACCURACY                 	7000 (medium resolution) and 10000 (high resolution)
MS:DATAFORMAT                    	.dat
MS:SCAN_RANGE_MOVERZ             	27-209
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	ng/mL plasma
MS_METABOLITE_DATA_START
Samples	M1	M10	M100	M101	M102	M103	M104	M105	M106	M107	M109	M11	M110	M111	M112	M113	M114	M115	M12	M13	M14	M15	M16	M17	M18	M19	M2	M20	M21	M22	M23	M24	M25	M26	M27	M28	M29	M3	M30	M31	M32	M33	M34	M35	M36	M37	M38	M39	M4	M40	M41	M42	M43	M44	M45	M46	M47	M48	M49	M5	M50	M51	M52	M53	M54	M55	M56	M57	M58	M6	M61	M62	M63	M64	M65	M66	M67	M68	M69	M7	M70	M71	M72	M73	M74	M75	M76	M77	M78	M79	M8	M80	M81	M82	M83	M84	M85	M86	M87	M88	M89	M9	M90	M91	M92	M93	M94	M95	M96	M97	M98	M99
Factors	Gender:F | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:African American	Gender:F | Race:Other	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:African American	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:F | Race:Other	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:African American	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:African American	Gender:M | Race:Caucasian	Gender:Pool | Race:Pool	Gender:M | Race:Other	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:African American	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Other	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:African American	Gender:F | Race:African American	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:African American	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:African American	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:F | Race:African American	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:African American	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:African American	Gender:F | Race:African American	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:African American	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:African American	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Other	Gender:F | Race:-	Gender:M | Race:Caucasian	Gender:M | Race:Other	Gender:M | Race:Other	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:F | Race:Caucasian	Gender:M | Race:Caucasian	Gender:M | Race:Caucasian	Gender:F | Race:Caucasian	Gender:Pool | Race:Pool
V	1.86	1.62	2.15			1.94				1.33			0.778	1.12	0.947	2.68	1.32	1.05	1.03		1.3			2.52			3.08	1.09	1.13		1.24		1.29	1.68	2.15	1.15	1.53	0.8		2.46					1.19	2.34	0.819	2.05	2.35	1.07		2.24	1.23		1.74	1.73			2.15	0.673			0.96	1.06	0.981	0.968	1.08	2	2.69	1.74	1.42	1.94		0.869	1.7		1.58	1.45		0.8		1.65	1.02	2.66		2.74		2.15	2.67		0.61	1.4		1.25	2.22	2.16		1.95	1.31			0.655	2.43	0.916		0.847		1.35		1.98		0.958
Cr	3.13	4.06	9.82	2.22	0.517	6.17	6.91				4.54	5.2	5.81				14	7.6	0.588		3.8	6.04		27.3		5.37	18	20.5		11.8		2.47		1.56	1.71		12		12.3		14.9	3.7	10.7	0.581		2.14		21	3.01	13	3.45	29.9	13.9			12.6	18.1	15		10.4			6.75				22.4	3.9		2.11			2.75		0.48	3.28	10.5	0.423		11.6		4.01	2.84			2.32	0.512				11.3		0.521		1.54	24.6	2.85			11.2	0.627		2.74	5.63	2.52	2.83		17.4		0.637	4.67	3.9
Mn	0.643	0.695		2.7	2.21	1.27	2.13	1.58	2.13		2.15	0.514			0.358	0.372	0.445		2.54	2.58	0.498	2.9	2.27	0.808	0.355	0.452	0.79	1.2		2.53	0.429	2.53	0.376	0.59	0.42	0.461	0.626	0.385	2.49	0.456	0.401	2.48	2.44	2.56	0.677	0.796	0.79	1.25	1.71	0.943	2.72	1.43	2.87	2.73	0.726	0.86	3.46	2.88	0.617	3.86	2.63	2.92	0.735	0.593	0.608	0.615	6.15	0.575	0.365		0.603	1.26	2.75	3.28	0.697	2.63	0.827	0.601	2.49	2.99	3.76		2.55		2.79		2.48			2.63	2.34		2.67	1.44	1.1	1.17	2.55		0.359	2.87	2.8	0.453	0.712		6.28		2.06	0.745	2.58	0.497	4.09	1.57
Co			0.452	0.59	2.4	0.452	0.412	0.446	0.526		0.48				0.393	0.525		0.537				0.41																															0.399	0.402					0.417								0.885					0.748		0.468						0.399			0.581									0.557	0.659	0.502	0.639	0.639	0.633	0.57	0.589	0.528	0.471		0.589	0.45	0.506	0.466	0.445	1.25	0.515	0.516	0.505	0.606
Ni	3.5	3.37	1.53	1.69		1.96		1.72	1.49	0.996	1.46	2.27		0.802	1.14	1.89	2.53	2.21	1.26	0.768	1.64	3.01	2.03	3.32	1.52	4.65	2.14	1.94	1.73	0.779	3.28	1.03	1.55	2.23	1.67	3.34	1.71	2.71	1.59	1.62	1	2.54	2.44	2.02	2.24	1.61	1.71	2.8	2.8	3.98	0.896	2.09	1.09	1.64	1.97	1.51	1.13	1.23	2.95	2.18		3.48	2.51	2.29	1.7	2.35	1.86		1.22	1.76	2.35	4.07	1.99		2.43	0.78	2.37	2.61	2.08	2.09	0.832	0.752		0.94		2.42	1.22				2.77	0.864	1.19	1.36	1.69	1.88	3.82	3.12	2.58	3.21		2.15	1.64	1.81	1.19	1.81	2.37	1.55		2.39	6.53	2.03
Cu	915	908	531	1140	1030	758	898	777	930	605	960	658	552	875	829	711	1090	752	578	944	747	885	602	1060	570	865	940	578	523	1010	613	779	631	833	788	751	759	853	1050	695	451	814	818	568	593	1110	780	734	785	506	1290	630	671	508	834	541	864	849	1180	807	938	295	696	1010	978	818	711	1000	1030	922	656	725	706	1280	921	766	625	595	618	1250	724	729	662	1200	1440	992	1360	1000	1030	633	659	609	754	592	658	620	737	652	372	1000	458	933	523	690	760	927	795	1040	847	631	554	1020
Zn	538	584	646	441	457	503	459	487	494	566	731	825	590	575	543	522	534	405	460	717	676	499	469	483	644	705	595	449	604	429	598	515	552	640	437	615	710	590	465	591	569	524	648	528	570	627	569	521	528	752	657	757	519	549	478	530	578	530	639	528	593	647	494	549	520	543	785	823	917	451	746	601	463	555	579	559	688	587	678	563	610	812			1170	1210	1120	951	1300		611	654	756	1160	515	447	614	537	454	593	408	486	675	449	791	570	408		497	514	505	701
Mo	6.65	2.95	1.67	5.64	1.21	5.32	1.85	2.91	3.52	2.04	6.83	7.33	4.48	2.1	3.27	5.57	5.28	3.02	1.59	4.09	3.3	3.1	3.81	1.62	5.77	2.73	5.19	2.76	3.77	10.5	4.26	5	7.49	2.51	3.22	4.67	2.22	1.51	2.95	1.87	2.89	3.78	1.79		7.1	3.46	12.7	5.66	4.04	5.67	0.874	2.18	2.6	2.4	7.02	1.7	2.4	1.48	7.41	3.34	2.48	1.3	0.97	1.12	5.54	6.45	2.45	5.7	3.97	1.39	3.42	4.44	0.848	1.69	3.26	2.73	3.17	4.62	4.51	3.24	1.94	4.96	6.77	4.28	4.22	7.04	1.96	2.48	7.5	10.4	7.68	4.09	3.98	4.02	3.92	3.41	9.71	5.67	3.72	4.05	3.86	5.3	2.08	6.82	2.21	2.67	8.24		1.21	1.85	7.09	5.1
Cd		0.141	0.212	0.198	0.138	0.274	0.109	0.233	0.161	0.27	0.235	0.2	0.131	0.143	0.156	0.307	0.27	0.222				0.114					0.204		0.224		0.139		0.116	0.195		0.667		0.196							0.199	0.244	0.319	0.185		0.216	0.141	0.226	0.155	0.214	0.243	0.205	0.179	0.173			0.147	0.281	0.177	0.237	0.224	0.252	0.243	0.325	0.249	0.129	0.249	0.569	0.171	0.171	0.356	0.192	0.264	0.209	0.222		0.246	0.373	0.309	0.279	0.214	0.329		0.22	0.358		0.259	0.217	0.171	0.194	0.203	0.423	0.218	0.22	0.256	0.201	0.182	0.174	0.21	0.266		0.42	0.218	0.24	0.108	0.32	0.239	0.251
Sn	1.59	2.18	4.67	2.16	1.45	2.75		1.62	1.48	4.62	1.7	15.8	1.39	0.842	0.879	2.27	4.28	3.97	1.27		0.757	1.5	1.32	2.65		0.97	2.99	1.69	4.75		2.44	0.492	2.18	5.3	0.61	6.53	1.56	5.39	0.497	2.28	0.609	1.75	0.968	0.86	1.86	1.33	1.14	5.79	2.33	1.12		2.51	0.745	1.3	2.29	1.64	0.444	0.874	5.56	0.847		1.39	1.81	2.68	1.36	1.63	2.44	1.21	1.72	2.5	1.76	10.2	1.18	0.698	4.78	2.06	3.41	1.69	1.26	1.9	0.55	4.59	0.61	2.49	0.867	2.98	6.53	1.21	3.26	7.71	6.05	2.22	1.05	1.09	1.05	8.06	1.03	1.79	1.29	1.83	1.8	1.69	2.64	3.38	0.736	8.45	1.7	2.68	0.977	5.23	2.46	3.32
Sb	4.44	3.78	3.26	3.73	4.01	3.6	3.24	2.46	3.26	3.2	3.02	2.87	4.42	4.09	4.59	3.59	3.75	3.5	2.98	3.39	3.54	4.38	3.58	4.1	4.67	3.65	3.99	2.62	5.62	3.98	3.7	3.32	3.62	4.35	3.09	4.68	3.88	3.92	3.65	4.73	3.7	3.86	3.08	3.68	3.35	4.86	5.06	4.68	3.51	3.42	4	4.46	3.48	2.87	3.69	3.3	3.22	3.85	3.51	6.05	3.84	4.15	3.23	3.54	3.99	3.75	3.68	5.8	4.55	4.17	2.87	3.95	3.49	5.17	4.09	3.88	3.92	2.68	3	3.68	6.83	4.03	4.38	4.56	4.55	6.23	3.9	4.94	4.79	4.5	3.15	3.85	4.49	3.52	4.55	3.46	4.19	3.33	4.42	3.97	3.39	2.78	4.01	3.54	4	3.03	3.07	2.84	4.23	4.24	3.01	4.56
Pb	0.377	0.413				0.864	0.586		0.352						0.452																									0.426				0.471	0.403	0.333	0.452	0.747				0.701	0.515	0.32	0.442	0.353			0.416	0.316			0.383	0.384	0.451	0.394	0.493	0.474	0.332		0.338	0.693	0.33		0.396	0.91	0.391	0.404	0.751		0.525	0.621				0.416	0.466					2.08				0.596	0.47			1.85	0.717			0.725						1.02	1.94	
As				6.5							6.94		6.5			11															11.7																													6.49																			7.65																		20.9									7.98				11.6	7.83	
Se	94.7	126	122	88	98.5	106	102	94.4	104	96.4	107	112	107	104	119	118	105	110	119	109	143	98.1	116	99.8	99.7	120	127	81.1	123	102	126	114	121	140	120	68.6	126	108	91.7	140	93.8	143	139	108	110	93.1	103	119	124	133	114	146	122	132	113	124	136	107	116	85.4	152	73.7	101	127	117	111	129	172	142	92.7	100	118	60.3	98.7	113	108	112	138	145	87.6	179	162	113	148	155	184	151	121	169	154	113	77.4	120	113	126	114	99.1	126	126	105	97	81.8	145	87.4	109	86.1	80.4	117	100	97.9	102	143
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	retention index	quantified m/z	PubChem ID	KEGG ID
V			23990
Cr			23976
Mn			23930
Co			104730
Ni			935
Cu			23978
Zn			23994
Mo			23932
Cd			23973
Sn			5352426
Sb			5354495
Pb			5352425
As			5359596
Se			6326970
METABOLITES_END
#END