#METABOLOMICS WORKBENCH hormel101_20170303_115623_mwtab.txt DATATRACK_ID:859 STUDY_ID:ST000567 ANALYSIS_ID:AN000871 PROJECT_ID:PR000387
VERSION             	1
CREATED_ON             	March 6, 2017, 7:51 pm
#PROJECT
PR:PROJECT_TITLE                 	Mayo Metabolomics Pilot and Feasibility Award: Effects of Curcumin
PR:PROJECT_TITLE                 	Supplementation on the Plasma Metabolome of Older Adults: Relation to Vascular
PR:PROJECT_TITLE                 	Function
PR:PROJECT_SUMMARY               	Age is the major risk factor for cardiovascular diseases (CVD). Two key
PR:PROJECT_SUMMARY               	contributors to the increased risk of CVD in middle-aged and older (MA/O) adults
PR:PROJECT_SUMMARY               	are stiffening of the large elastic arteries and the development of vascular
PR:PROJECT_SUMMARY               	endothelial dysfunction, indicated by impaired nitric oxide (NO)-induced
PR:PROJECT_SUMMARY               	endothelium-dependent dilation (EDD). The mechanisms by which aging causes
PR:PROJECT_SUMMARY               	arterial dysfunction are incompletely understood, but involve reductions in NO
PR:PROJECT_SUMMARY               	bioavailability associated with the development of oxidative stress and
PR:PROJECT_SUMMARY               	inflammation. Thus, establishing novel strategies to reduce arterial stiffness
PR:PROJECT_SUMMARY               	and increase vascular endothelial function in MA/O adults by increasing NO
PR:PROJECT_SUMMARY               	bioavailability and reducing oxidative stress and inflammation are a high
PR:PROJECT_SUMMARY               	biomedical research priority. Curcumin is a naturally occurring phenol found in
PR:PROJECT_SUMMARY               	the Indian spice turmeric that improves physiological function in animal models
PR:PROJECT_SUMMARY               	of age-related diseases and is a promising nutraceutical for intervention for
PR:PROJECT_SUMMARY               	promoting healthy aging. Our preclinical results indicate that chow supplemented
PR:PROJECT_SUMMARY               	with curcumin reduces aortic pulse wave velocity (PWV), the most common and
PR:PROJECT_SUMMARY               	clinically important measure of large elastic artery stiffness, restores
PR:PROJECT_SUMMARY               	NO-mediated EDD and reduces arterial oxidative stress and inflammation in old
PR:PROJECT_SUMMARY               	C57/BL6 mice. Preliminary data from our recently funded NIH R21 pilot grant
PR:PROJECT_SUMMARY               	indicate that curcumin supplementation improves vascular function in humans. It
PR:PROJECT_SUMMARY               	is possible that changes in the circulating (plasma) metabolome with oral
PR:PROJECT_SUMMARY               	curcumin supplementation will provide insight into novel metabolic mechanisms by
PR:PROJECT_SUMMARY               	which curcumin may improve vascular function. The goal of this project is to
PR:PROJECT_SUMMARY               	identify key metabolic pathways that change with oral curcumin supplementation
PR:PROJECT_SUMMARY               	and to relate those changes with improvements in vascular function in MA/O
PR:PROJECT_SUMMARY               	adults with initial endothelial dysfunction. Metabolomic analysis of plasma
PR:PROJECT_SUMMARY               	samples at baseline also may produce unique molecular signatures that predict
PR:PROJECT_SUMMARY               	responsiveness (changes in vascular function) to curcumin supplementation among
PR:PROJECT_SUMMARY               	individuals.
PR:INSTITUTE                     	Mayo Clinic
PR:LAST_NAME                     	Seals
PR:FIRST_NAME                    	Douglas
PR:ADDRESS                       	Department of Integrative Physiology University of Colorado Boulder, CO 80309
PR:EMAIL                         	seals@colorado.edu
PR:PHONE                         	303-492-5305
#STUDY
ST:STUDY_TITLE                   	Large Scale HILIC Profiling of the Effects of Curcumin Supplementation of Older
ST:STUDY_TITLE                   	Adults: Relation to Vascular Function
ST:STUDY_SUMMARY                 	Perform large scale profiling HILIC metabolite analysis related to nitric oxide
ST:STUDY_SUMMARY                 	biology, oxidative stress and inflammation in plasma before and after 12 weeks
ST:STUDY_SUMMARY                 	of oral curcumin (2000 mg/d) or placebo (double-blind, randomized) in men and
ST:STUDY_SUMMARY                 	women aged 45-79 years who are free from clinical cardiovascular disease.
ST:INSTITUTE                     	Mayo Clinic
ST:LAST_NAME                     	Seals
ST:FIRST_NAME                    	Douglas
ST:ADDRESS                       	Department of Integrative Physiology University of Colorado Boulder, CO 80309
ST:EMAIL                         	seals@colorado.edu
ST:PHONE                         	303-492-5305
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	1	17may15_004-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	1	17may15_004-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	2	17may15_005-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	2	17may15_005-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	2	17may15_006-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	2	17may15_006-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	3	17may15_007-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	3	17may15_007-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	3	17may15_008-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	3	17may15_008-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	4	17may15_009-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	4	17may15_009-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	5	17may15_010-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	5	17may15_010-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	5	17may15_011-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	5	17may15_011-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	6	17may15_012-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	6	17may15_012-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	6	17may15_013-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	6	17may15_013-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	7	17may15_014-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	7	17may15_014-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	8	17may15_015-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	8	17may15_015-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	8	17may15_016-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	8	17may15_016-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	9	17may15_017-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	9	17may15_017-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	9	17may15_018-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	9	17may15_018-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	10	17may15_019-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	10	17may15_019-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	11	17may15_020-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	11	17may15_020-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	11	17may15_021-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	11	17may15_021-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	12	17may15_022-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	12	17may15_022-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	12	17may15_023-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	12	17may15_023-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	13	17may15_024-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	13	17may15_024-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	13	17may15_025-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	13	17may15_025-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	14	17may15_026-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	14	17may15_026-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	15	17may15_027-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	15	17may15_027-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	15	17may15_028-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	15	17may15_028-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	16	17may15_029-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	16	17may15_029-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	16	17may15_030-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	16	17may15_030-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	17	17may15_031-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	17	17may15_031-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	17	17may15_032-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	17	17may15_032-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	18	17may15_033-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	18	17may15_033-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	19	17may15_034-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	19	17may15_034-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	19	17may15_035-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	19	17may15_035-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	20	17may15_036-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	20	17may15_036-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	20	17may15_037-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	20	17may15_037-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	21	17may15_038-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	21	17may15_038-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	21	17may15_039-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	21	17may15_039-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	22	17may15_040-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	22	17may15_040-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	23	18may15_004-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	23	18may15_004-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	24	18may15_005-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	24	18may15_005-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	24	18may15_006-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	24	18may15_006-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	25	18may15_007-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	25	18may15_007-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	25	18may15_008-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	25	18may15_008-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	26	18may15_009-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	26	18may15_009-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	27	18may15_010-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	27	18may15_010-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	27	18may15_011-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	27	18may15_011-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	28	18may15_012-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	28	18may15_012-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	28	18may15_013-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	28	18may15_013-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	29	18may15_014-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	29	18may15_014-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	30	18may15_015-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	30	18may15_015-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	30	18may15_016-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	30	18may15_016-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	31	18may15_017-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	31	18may15_017-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	31	18may15_018-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	31	18may15_018-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	32	18may15_019-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	32	18may15_019-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	33	18may15_020-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	33	18may15_020-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	33	18may15_021-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	33	18may15_021-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	34	18may15_022-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	34	18may15_022-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	34	18may15_023-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	34	18may15_023-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	35	18may15_024-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	35	18may15_024-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	35	18may15_025-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	35	18may15_025-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	36	18may15_026-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	36	18may15_026-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	37	18may15_027-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	37	18may15_027-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	37	18may15_028-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	37	18may15_028-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	38	18may15_029-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	38	18may15_029-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	38	18may15_030-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	38	18may15_030-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	39	18may15_031-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	39	18may15_031-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	39	18may15_032-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	39	18may15_032-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	40	18may15_033-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	40	18may15_033-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	41	18may15_034-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	41	18may15_034-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	41	18may15_035-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	41	18may15_035-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	42	18may15_038-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	42	18may15_038-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	42	18may15_039-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	42	18may15_039-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	43	18may15_040-r001	groups:young | Time point:Baseline | replicate:1	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	43	18may15_040-r002	groups:young | Time point:Baseline | replicate:2	ionmode=NHILIC
SUBJECT_SAMPLE_FACTORS           	1	13may15_004-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	1	13may15_004-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	2	13may15_005-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	2	13may15_005-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	2	13may15_006-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	2	13may15_006-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	3	13may15_007-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	3	13may15_007-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	3	13may15_008-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	3	13may15_008-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	4	13may15_009-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	4	13may15_009-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	5	13may15_010-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	5	13may15_010-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	5	13may15_011-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	5	13may15_011-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	6	13may15_012-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	6	13may15_012-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	6	13may15_013-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	6	13may15_013-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	7	13may15_014-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	7	13may15_014-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	8	13may15_015-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	8	13may15_015-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	8	13may15_016-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	8	13may15_016-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	9	13may15_017-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	9	13may15_017-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	9	13may15_018-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	9	13may15_018-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	10	13may15_019-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	10	13may15_019-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	11	13may15_020-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	11	13may15_020-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	11	13may15_021-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	11	13may15_021-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	12	13may15_022-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	12	13may15_022-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	12	13may15_023-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	12	13may15_023-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	13	13may15_024-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	13	13may15_024-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	13	13may15_025-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	13	13may15_025-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	14	13may15_026-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	14	13may15_026-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	15	13may15_027-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	15	13may15_027-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	15	13may15_028-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	15	13may15_028-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	16	13may15_029-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	16	13may15_029-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	16	13may15_030-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	16	13may15_030-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	17	13may15_031-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	17	13may15_031-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	17	13may15_032-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	17	13may15_032-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	18	13may15_033-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	18	13may15_033-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	19	13may15_034-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	19	13may15_034-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	19	13may15_035-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	19	13may15_035-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	20	13may15_036-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	20	13may15_036-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	20	13may15_037-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	20	13may15_037-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	21	13may15_038-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	21	13may15_038-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	21	13may15_039-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	21	13may15_039-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	22	13may15_040-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	22	13may15_040-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	23	15may15_004-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	23	15may15_004-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	24	15may15_005-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	24	15may15_005-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	24	15may15_006-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	24	15may15_006-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	25	15may15_007-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	25	15may15_007-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	25	15may15_008-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	25	15may15_008-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	26	15may15_009-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	26	15may15_009-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	27	15may15_010-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	27	15may15_010-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	27	15may15_011-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	27	15may15_011-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	28	15may15_012-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	28	15may15_012-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	28	15may15_013-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	28	15may15_013-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	29	15may15_014-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	29	15may15_014-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	30	15may15_015-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	30	15may15_015-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	30	15may15_016-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	30	15may15_016-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	31	15may15_017-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	31	15may15_017-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	31	15may15_018-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	31	15may15_018-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	32	15may15_019-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	32	15may15_019-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	33	15may15_020-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	33	15may15_020-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	33	15may15_021-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	33	15may15_021-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	34	15may15_022-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	34	15may15_022-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	34	15may15_023-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	34	15may15_023-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	35	15may15_024-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	35	15may15_024-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	35	15may15_025-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	35	15may15_025-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	36	15may15_026-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	36	15may15_026-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	37	15may15_027-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	37	15may15_027-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	37	15may15_028-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	37	15may15_028-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	38	15may15_029-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	38	15may15_029-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	38	15may15_030-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	38	15may15_030-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	39	15may15_031-r001	groups:Old-Curcumin | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	39	15may15_031-r002	groups:Old-Curcumin | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	39	15may15_032-r001	groups:Old-Curcumin | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	39	15may15_032-r002	groups:Old-Curcumin | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	40	15may15_033-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	40	15may15_033-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	41	15may15_034-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	41	15may15_034-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	41	15may15_035-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	41	15may15_035-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	42	15may15_038-r001	groups:Old-Placebo | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	42	15may15_038-r002	groups:Old-Placebo | Time point:Pre | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	42	15may15_039-r001	groups:Old-Placebo | Time point:Post | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	42	15may15_039-r002	groups:Old-Placebo | Time point:Post | replicate:2	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	43	15may15_040-r001	groups:young | Time point:Pre | replicate:1	ionmode=PHILIC
SUBJECT_SAMPLE_FACTORS           	43	15may15_040-r002	groups:young | Time point:Pre | replicate:2	ionmode=PHILIC
#COLLECTION
CO:COLLECTION_SUMMARY            	Healthy men & women aged 45-79 without clinical CVD, but with below normal
CO:COLLECTION_SUMMARY            	baseline endothelial dysfunction (FMDBA < 7%).
#TREATMENT
TR:TREATMENT_SUMMARY             	"A 12-week randomized, double-blind, placebo controlled study will be conducted.
TR:TREATMENT_SUMMARY             	After CTRC screening for inclusion/exclusion criteria, qualified subjects will
TR:TREATMENT_SUMMARY             	be randomly assigned to 1 of 2 groups. The investigators involved in the
TR:TREATMENT_SUMMARY             	acquisition and analysis of key outcomes will be blinded to the curcumin intake
TR:TREATMENT_SUMMARY             	status of the subjects. With the assistance of dietary monitoring from the
TR:TREATMENT_SUMMARY             	UC-Boulder CTRC bionutritionists, subjects will maintain their baseline diet
TR:TREATMENT_SUMMARY             	with either unchanged (control) or enhanced curcumin intake delivered as
TR:TREATMENT_SUMMARY             	capsules (Longvida®, Verdure Sciences): Group 1 = placebo (inert substances);
TR:TREATMENT_SUMMARY             	Group 2 = curcumin (2000mg curcumin/day). Extensive published work has
TR:TREATMENT_SUMMARY             	established that the curcumin dose of 2000 mg/day is well tolerated and safe.
TR:TREATMENT_SUMMARY             	Sessions 1 & 2: Screening measurements. Session 3: Baseline measurements and
TR:TREATMENT_SUMMARY             	blood draw. Sessions 4-8 (every other week to assess adherence and overall
TR:TREATMENT_SUMMARY             	subject well-being): Body weight, BP, adherence, discuss any problems. Session
TR:TREATMENT_SUMMARY             	9: Identical to session 3 (stop intake of capsules after completion of
TR:TREATMENT_SUMMARY             	post-testing)."
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Venous blood sampling. All blood samples are handled in a similar time frame and
SP:SAMPLEPREP_SUMMARY            	immediately spun to extract plasma and stored in our -80 freezer until ready for
SP:SAMPLEPREP_SUMMARY            	analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Waters Acquity
CH:COLUMN_NAME                   	Waters Acquity BEH Amide (150 x 2.1mm, 1.7um)
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:MS_COMMENTS                   	-
MS:INSTRUMENT_NAME               	Agilent 6550 QTOF
MS:INSTRUMENT_TYPE               	QTOF
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_RESULTS_FILE               	ST000567_AN000871_Results.txt	UNITS:intensity	Has m/z:Yes	Has RT:Yes
#END