#METABOLOMICS WORKBENCH flingrus_20200403_125632 DATATRACK_ID:1980 STUDY_ID:ST001376 ANALYSIS_ID:AN002296
VERSION                          	1
CREATED_ON                       	02-08-2024
#PROJECT
PR:PROJECT_TITLE                 	TCDD-elicited effects on metabolite levels in liver of male mice treated with
PR:PROJECT_TITLE                 	sesame oil
PR:PROJECT_TYPE                  	Untargetd Metabolomics
PR:PROJECT_SUMMARY               	Experiment to study TCDD-elicited effects on metabolite levels in liver of male
PR:PROJECT_SUMMARY               	mice treated with sesame oil vehicle or 0.01-30 ug/kg TCDD every 4 days for 28
PR:PROJECT_SUMMARY               	days.
PR:INSTITUTE                     	Michigan State University
PR:DEPARTMENT                    	Biochemistry and Molecular Biology
PR:LAST_NAME                     	Fling
PR:FIRST_NAME                    	Russell
PR:ADDRESS                       	1129 Farm Ln, East Lansing, MI,USA
PR:EMAIL                         	flingrus@msu.edu
PR:PHONE                         	(517) 884-2054
PR:PUBLICATIONS                  	-
PR:DOI                           	http://dx.doi.org/10.21228/M8912S
#STUDY
ST:STUDY_TITLE                   	2,3,7,8 -Tetrachlorodibenzo-p-dioxin Mediated Effects on Hepatic Coenzyme A
ST:STUDY_TITLE                   	(CoA) and Acetyl-CoA Levels (part-I)
ST:STUDY_TYPE                    	Dioxin
ST:STUDY_SUMMARY                 	Experiment to study TCDD-elicited effects on hepatic Coenzyme A (CoA) and
ST:STUDY_SUMMARY                 	Acetyl-CoA levels in liver of male mice treated with sesame oil vehicle or
ST:STUDY_SUMMARY                 	0.01-30 ug/kg TCDD every 4 days for 28 days.
ST:INSTITUTE                     	Michigan State University
ST:DEPARTMENT                    	Biochemistry and Molecular Biology
ST:LABORATORY                    	Zacharewski Lab
ST:LAST_NAME                     	Fling
ST:FIRST_NAME                    	Russell
ST:ADDRESS                       	1129 Farm Ln, East Lansing, MI, USA
ST:EMAIL                         	flingrus@msu.edu
ST:PHONE                         	(517) 884-2054
ST:SUBMIT_DATE                   	2020-04-03
#SUBJECT
SU:SUBJECT_TYPE                  	Mammalian Subjects
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
SU:GENOTYPE_STRAIN               	C57BL/6
SU:AGE_OR_AGE_RANGE              	postnatal day 56
SU:GENDER                        	Male
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	-	10	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_086.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:14:13
SUBJECT_SAMPLE_FACTORS           	-	10_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_086.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:14:13
SUBJECT_SAMPLE_FACTORS           	-	6	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_024.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=5:33:29
SUBJECT_SAMPLE_FACTORS           	-	6_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_024.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=5:33:29
SUBJECT_SAMPLE_FACTORS           	-	7	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_035.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:09:03
SUBJECT_SAMPLE_FACTORS           	-	7_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_035.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:09:03
SUBJECT_SAMPLE_FACTORS           	-	8	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_056.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:53:34
SUBJECT_SAMPLE_FACTORS           	-	8_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_056.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:53:34
SUBJECT_SAMPLE_FACTORS           	-	9	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_078.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:41:53
SUBJECT_SAMPLE_FACTORS           	-	9_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_090519_078.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:41:53
SUBJECT_SAMPLE_FACTORS           	-	17	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_039.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:12:58
SUBJECT_SAMPLE_FACTORS           	-	17_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_039.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:12:58
SUBJECT_SAMPLE_FACTORS           	-	18	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_050.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:11:47
SUBJECT_SAMPLE_FACTORS           	-	18_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_050.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:11:47
SUBJECT_SAMPLE_FACTORS           	-	19	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_074.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:45:09
SUBJECT_SAMPLE_FACTORS           	-	19_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_074.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:45:09
SUBJECT_SAMPLE_FACTORS           	-	20	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_094.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:18:10
SUBJECT_SAMPLE_FACTORS           	-	20_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_094.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:18:10
SUBJECT_SAMPLE_FACTORS           	-	26	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_018.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=5:41:25
SUBJECT_SAMPLE_FACTORS           	-	26_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_018.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=5:41:25
SUBJECT_SAMPLE_FACTORS           	-	27	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_033.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:16:20
SUBJECT_SAMPLE_FACTORS           	-	27_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_033.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:16:20
SUBJECT_SAMPLE_FACTORS           	-	28	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_060.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:15:18
SUBJECT_SAMPLE_FACTORS           	-	28_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_060.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:15:18
SUBJECT_SAMPLE_FACTORS           	-	29	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_070.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:48:42
SUBJECT_SAMPLE_FACTORS           	-	29_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_070.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:48:42
SUBJECT_SAMPLE_FACTORS           	-	30	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_096.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:20:56
SUBJECT_SAMPLE_FACTORS           	-	30_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_090519_096.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:20:56
SUBJECT_SAMPLE_FACTORS           	-	36	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_014.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=5:45:15
SUBJECT_SAMPLE_FACTORS           	-	36_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_014.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=5:45:15
SUBJECT_SAMPLE_FACTORS           	-	37	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_037.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:30:12
SUBJECT_SAMPLE_FACTORS           	-	37_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_037.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:30:12
SUBJECT_SAMPLE_FACTORS           	-	38	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_058.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:18:36
SUBJECT_SAMPLE_FACTORS           	-	38_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_058.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:18:36
SUBJECT_SAMPLE_FACTORS           	-	39	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_068.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:53:42
SUBJECT_SAMPLE_FACTORS           	-	39_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_090519_068.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:53:42
SUBJECT_SAMPLE_FACTORS           	-	46	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_012.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=5:48:59
SUBJECT_SAMPLE_FACTORS           	-	46_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_012.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=5:48:59
SUBJECT_SAMPLE_FACTORS           	-	47	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_031.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:20:14
SUBJECT_SAMPLE_FACTORS           	-	47_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_031.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:20:14
SUBJECT_SAMPLE_FACTORS           	-	48	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_048.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:22:17
SUBJECT_SAMPLE_FACTORS           	-	48_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_048.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:22:17
SUBJECT_SAMPLE_FACTORS           	-	49	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_084.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:57:17
SUBJECT_SAMPLE_FACTORS           	-	49_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_090519_084.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:57:17
SUBJECT_SAMPLE_FACTORS           	-	56	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_010.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=5:53:06
SUBJECT_SAMPLE_FACTORS           	-	56_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_010.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=5:53:06
SUBJECT_SAMPLE_FACTORS           	-	58	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_064.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:26:39
SUBJECT_SAMPLE_FACTORS           	-	58_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_064.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:26:39
SUBJECT_SAMPLE_FACTORS           	-	59	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_076.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:00:36
SUBJECT_SAMPLE_FACTORS           	-	59_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_076.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:00:36
SUBJECT_SAMPLE_FACTORS           	-	60	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_088.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:29:46
SUBJECT_SAMPLE_FACTORS           	-	60_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_090519_088.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:29:46
SUBJECT_SAMPLE_FACTORS           	-	76	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_022.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:01:34
SUBJECT_SAMPLE_FACTORS           	-	76_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_022.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:01:34
SUBJECT_SAMPLE_FACTORS           	-	77	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_029.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:39:31
SUBJECT_SAMPLE_FACTORS           	-	77_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_029.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:39:31
SUBJECT_SAMPLE_FACTORS           	-	78	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_052.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:33:48
SUBJECT_SAMPLE_FACTORS           	-	78_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_052.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:33:48
SUBJECT_SAMPLE_FACTORS           	-	79	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_080.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:07:40
SUBJECT_SAMPLE_FACTORS           	-	79_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_080.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:07:40
SUBJECT_SAMPLE_FACTORS           	-	80	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_090.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:35:49
SUBJECT_SAMPLE_FACTORS           	-	80_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_090519_090.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:35:49
SUBJECT_SAMPLE_FACTORS           	-	66	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_020.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=5:56:46
SUBJECT_SAMPLE_FACTORS           	-	66_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_020.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=5:56:46
SUBJECT_SAMPLE_FACTORS           	-	67	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_041.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:33:55
SUBJECT_SAMPLE_FACTORS           	-	67_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_041.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:33:55
SUBJECT_SAMPLE_FACTORS           	-	68	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_062.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:30:22
SUBJECT_SAMPLE_FACTORS           	-	68_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_062.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:30:22
SUBJECT_SAMPLE_FACTORS           	-	69	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_082.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:03:47
SUBJECT_SAMPLE_FACTORS           	-	69_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_082.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:03:47
SUBJECT_SAMPLE_FACTORS           	-	70	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_098.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:32:58
SUBJECT_SAMPLE_FACTORS           	-	70_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_090519_098.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:32:58
SUBJECT_SAMPLE_FACTORS           	-	86	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_016.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:04:56
SUBJECT_SAMPLE_FACTORS           	-	86_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_016.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:04:56
SUBJECT_SAMPLE_FACTORS           	-	87	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_043.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=6:42:43
SUBJECT_SAMPLE_FACTORS           	-	87_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_043.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=6:42:43
SUBJECT_SAMPLE_FACTORS           	-	89	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_054.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=7:37:33
SUBJECT_SAMPLE_FACTORS           	-	89_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_054.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=7:37:33
SUBJECT_SAMPLE_FACTORS           	-	90	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_092.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=8:10:53
SUBJECT_SAMPLE_FACTORS           	-	90_1uM_Coa_added	Collection Time:Afternoon | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_090519_092.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=8:10:53
SUBJECT_SAMPLE_FACTORS           	-	1	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_025.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:00:11
SUBJECT_SAMPLE_FACTORS           	-	1_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_025.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:00:11
SUBJECT_SAMPLE_FACTORS           	-	2	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_033.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:38:05
SUBJECT_SAMPLE_FACTORS           	-	2_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_033.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:38:05
SUBJECT_SAMPLE_FACTORS           	-	3	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_069.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:18:00
SUBJECT_SAMPLE_FACTORS           	-	3_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_069.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:18:00
SUBJECT_SAMPLE_FACTORS           	-	4	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_073.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:07:51
SUBJECT_SAMPLE_FACTORS           	-	4_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_073.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:07:51
SUBJECT_SAMPLE_FACTORS           	-	5	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_100.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:36:42
SUBJECT_SAMPLE_FACTORS           	-	5_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):-	RAW_FILE_NAME=XS1_082919_100.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:36:42
SUBJECT_SAMPLE_FACTORS           	-	11	Collection Time:Morning | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_072.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:04:36
SUBJECT_SAMPLE_FACTORS           	-	11_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_090519_072.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:04:36
SUBJECT_SAMPLE_FACTORS           	-	13	Collection Time:Morning | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_082919_061.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:22:18
SUBJECT_SAMPLE_FACTORS           	-	13_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_082919_061.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:22:18
SUBJECT_SAMPLE_FACTORS           	-	15	Collection Time:Morning | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_082919_104.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:11:10
SUBJECT_SAMPLE_FACTORS           	-	15_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.01	RAW_FILE_NAME=XS1_082919_104.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:11:10
SUBJECT_SAMPLE_FACTORS           	-	21	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_027.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:09:35
SUBJECT_SAMPLE_FACTORS           	-	21_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_027.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:09:35
SUBJECT_SAMPLE_FACTORS           	-	22	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_039.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:46:22
SUBJECT_SAMPLE_FACTORS           	-	22_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_039.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:46:22
SUBJECT_SAMPLE_FACTORS           	-	23	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_055.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:26:34
SUBJECT_SAMPLE_FACTORS           	-	23_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_055.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:26:34
SUBJECT_SAMPLE_FACTORS           	-	24	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_084.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:14:25
SUBJECT_SAMPLE_FACTORS           	-	24_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.03	RAW_FILE_NAME=XS1_082919_084.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:14:25
SUBJECT_SAMPLE_FACTORS           	-	31	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_019.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=-
SUBJECT_SAMPLE_FACTORS           	-	31_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_019.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=-
SUBJECT_SAMPLE_FACTORS           	-	32	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_047.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:49:55
SUBJECT_SAMPLE_FACTORS           	-	32_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_047.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:49:55
SUBJECT_SAMPLE_FACTORS           	-	33	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_051.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:47:11
SUBJECT_SAMPLE_FACTORS           	-	33_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_051.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:47:11
SUBJECT_SAMPLE_FACTORS           	-	34	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_086.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:18:44
SUBJECT_SAMPLE_FACTORS           	-	34_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_086.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:18:44
SUBJECT_SAMPLE_FACTORS           	-	35	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_090.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:40:07
SUBJECT_SAMPLE_FACTORS           	-	35_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.1	RAW_FILE_NAME=XS1_082919_090.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:40:07
SUBJECT_SAMPLE_FACTORS           	-	41	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_031.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:18:21
SUBJECT_SAMPLE_FACTORS           	-	41_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_031.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:18:21
SUBJECT_SAMPLE_FACTORS           	-	42	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_045.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:53:55
SUBJECT_SAMPLE_FACTORS           	-	42_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_045.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:53:55
SUBJECT_SAMPLE_FACTORS           	-	43	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_067.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:51:07
SUBJECT_SAMPLE_FACTORS           	-	43_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_067.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:51:07
SUBJECT_SAMPLE_FACTORS           	-	44	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_088.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:22:26
SUBJECT_SAMPLE_FACTORS           	-	44_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_088.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:22:26
SUBJECT_SAMPLE_FACTORS           	-	45	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_096.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:43:01
SUBJECT_SAMPLE_FACTORS           	-	45_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):0.3	RAW_FILE_NAME=XS1_082919_096.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:43:01
SUBJECT_SAMPLE_FACTORS           	-	51	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_029.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:23:10
SUBJECT_SAMPLE_FACTORS           	-	51_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_029.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:23:10
SUBJECT_SAMPLE_FACTORS           	-	52	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_043.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:57:21
SUBJECT_SAMPLE_FACTORS           	-	52_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_043.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:57:21
SUBJECT_SAMPLE_FACTORS           	-	53	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_065.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:54:33
SUBJECT_SAMPLE_FACTORS           	-	53_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_065.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:54:33
SUBJECT_SAMPLE_FACTORS           	-	54	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_080.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:26:12
SUBJECT_SAMPLE_FACTORS           	-	54_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_080.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:26:12
SUBJECT_SAMPLE_FACTORS           	-	55	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_094.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:46:12
SUBJECT_SAMPLE_FACTORS           	-	55_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):1	RAW_FILE_NAME=XS1_082919_094.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:46:12
SUBJECT_SAMPLE_FACTORS           	-	71	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_023.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:30:25
SUBJECT_SAMPLE_FACTORS           	-	71_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_023.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:30:25
SUBJECT_SAMPLE_FACTORS           	-	72	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_049.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:05:24
SUBJECT_SAMPLE_FACTORS           	-	72_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_049.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:05:24
SUBJECT_SAMPLE_FACTORS           	-	73	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_053.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:00:57
SUBJECT_SAMPLE_FACTORS           	-	73_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_053.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:00:57
SUBJECT_SAMPLE_FACTORS           	-	74	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_071.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:33:42
SUBJECT_SAMPLE_FACTORS           	-	74_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_071.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:33:42
SUBJECT_SAMPLE_FACTORS           	-	75	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_102.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:51:01
SUBJECT_SAMPLE_FACTORS           	-	75_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):10	RAW_FILE_NAME=XS1_082919_102.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:51:01
SUBJECT_SAMPLE_FACTORS           	-	61	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_021.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:26:37
SUBJECT_SAMPLE_FACTORS           	-	61_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_021.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:26:37
SUBJECT_SAMPLE_FACTORS           	-	62	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_041.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:00:57
SUBJECT_SAMPLE_FACTORS           	-	62_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_041.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:00:57
SUBJECT_SAMPLE_FACTORS           	-	63	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_063.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:57:41
SUBJECT_SAMPLE_FACTORS           	-	63_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_063.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:57:41
SUBJECT_SAMPLE_FACTORS           	-	64	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_082.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:29:49
SUBJECT_SAMPLE_FACTORS           	-	64_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_082.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:29:49
SUBJECT_SAMPLE_FACTORS           	-	65	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_098.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:49:10
SUBJECT_SAMPLE_FACTORS           	-	65_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):3	RAW_FILE_NAME=XS1_082919_098.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:49:10
SUBJECT_SAMPLE_FACTORS           	-	82	Collection Time:Morning | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_082919_017.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=0:34:20
SUBJECT_SAMPLE_FACTORS           	-	82_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_082919_017.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=0:34:20
SUBJECT_SAMPLE_FACTORS           	-	84	Collection Time:Morning | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_082919_037.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=1:09:05
SUBJECT_SAMPLE_FACTORS           	-	84_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_082919_037.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=1:09:05
SUBJECT_SAMPLE_FACTORS           	-	85	Collection Time:Morning | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_082919_059.raw; CoA standard addition=no CoA std. addition; collection time (zietgeber time (H:MM:SS)=2:04:02
SUBJECT_SAMPLE_FACTORS           	-	85_1uM_Coa_added	Collection Time:Morning | TCDD treatment(ug/kg):30	RAW_FILE_NAME=XS1_082919_059.raw; CoA standard addition=1 uM CoA std addition; collection time (zietgeber time (H:MM:SS)=2:04:02
#COLLECTION
CO:COLLECTION_SUMMARY            	Mice were take down with CO2. Livers were excised and immediatley frozen in
CO:COLLECTION_SUMMARY            	liquid nitrogen. Collection time (Morning or Afternoon) denoted in sample
CO:COLLECTION_SUMMARY            	factors refers to take-down time. Morning cohort samples were collected from
CO:COLLECTION_SUMMARY            	when the light turned on (7 am, ZT0) to ZT3.5. Afternoon cohort samples were
CO:COLLECTION_SUMMARY            	collected from ZT5-8.5.
CO:COLLECTION_PROTOCOL_COMMENTS  	Time-point: 28; Time-point Unit: Days;
CO:SAMPLE_TYPE                   	Liver
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	oral gavage every 4 days for 28 days. 7 total exposures oral gavage every 4 days
TR:TREATMENT_SUMMARY             	for 28 days. 7 total exposures with vehicle or 0.01-30 ug/kg TCDD.
TR:TREATMENT_PROTOCOL_COMMENTS   	Administration Interval: 4; Administration Interval Unit: DAYS; Dose Unit:
TR:TREATMENT_PROTOCOL_COMMENTS   	ug/kg; Number of Administrations: 7; Chemical Soucre: AccuStandard; Chemical
TR:TREATMENT_PROTOCOL_COMMENTS   	Catalog Number: S-70982; Chemical Purity: -; Vehicle Substance: CHEBI 28119
TR:TREATMENT_COMPOUND            	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
TR:TREATMENT_ROUTE               	GAVAGE
TR:TREATMENT_DOSE                	0.01,0.03,0.1,0.3,1,3,10,30
TR:TREATMENT_DOSEVOLUME          	0.1 ml
TR:TREATMENT_DOSEDURATION        	28 DAYS;
TR:TREATMENT_VEHICLE             	Sesame oil
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Frozen liver tissue was homegenized in 1000 ul h20:methanol (5:3) mixture5 ml
SP:SAMPLEPREP_SUMMARY            	and homegenized, 625 ul chloroform was added,vortexed and spun down at 15,000G.
SP:SAMPLEPREP_SUMMARY            	800 ul of top layer was removed and blown down with nitrogen and reconstituted
SP:SAMPLEPREP_SUMMARY            	in 400 l 10mM tetrabutylammonium (TBA)+10mM acetate (pH 5). A further 1:16
SP:SAMPLEPREP_SUMMARY            	dilution was performed for analysis of acetyl-CoA. Coenzyme A (CoA) was measured
SP:SAMPLEPREP_SUMMARY            	by standard addition method by diluting with TBA containing CoA standard
SP:SAMPLEPREP_SUMMARY            	resulting in 1 uM CoA standard addition. 1 uM CoA standard addition samples are
SP:SAMPLEPREP_SUMMARY            	denoted in the subject sample factor section.
SP:SAMPLEPREP_PROTOCOL_FILENAME  	SP_190815_Acetyl-CoA_modified_Metabolomics_polarextraction.docx
SP:PROCESSING_METHOD             	Liquid extraction
SP:PROCESSING_STORAGE_CONDITIONS 	-80 C
#CHROMATOGRAPHY
CH:METHODS_FILENAME              	CH_190829_prj155_28RDDR_LC-MS_expiriment_settings_Xevo_G2-XS_QTof_NEG-mode.txt
CH:INSTRUMENT_NAME               	Acquity H (Waters)
CH:COLUMN_NAME                   	Ascentis Express C18 2.1x5cm (Waters)
CH:INTERNAL_STANDARD             	Acetyl-1,2-13C2 Coenzyme A Sodium Salt (A172214, Toronto Research Chemicals,
CH:INTERNAL_STANDARD             	Toronto, Canada)
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
AN:ANALYSIS_PROTOCOL_FILE        	MS_170814_prj140_28RDDR_liver_compound_measurements_QTOF1_NEG.txt
#MS
MS:INSTRUMENT_NAME               	Waters Xevo G2 XS QTof
MS:INSTRUMENT_TYPE               	TOF
MS:MS_TYPE                       	ESI
MS:MS_COMMENTS                   	Samples were run in MS^e mode. MassLynx V4.2 was used to measure area under the
MS:MS_COMMENTS                   	curve. Accurate mass and retention were used for identification of signal for
MS:MS_COMMENTS                   	respective metabolites.
MS:ION_MODE                      	NEGATIVE
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	nmol/mg total protein
MS_METABOLITE_DATA_START
Samples	10	6	7	8	9	17	18	19	20	26	27	28	29	30	36	37	38	39	46	47	48	49	56	58	59	60	76	77	78	79	80	66	67	68	69	70	87	89	90	1	2	3	4	5	11	13	15	21	22	23	24	31	32	33	34	35	41	42	43	44	45	51	52	53	54	55	71	72	73	74	75	61	62	63	64	65	82	84	85
Factors	Collection Time:Afternoon | TCDD treatment(ug/kg):-	Collection Time:Afternoon | TCDD treatment(ug/kg):-	Collection Time:Afternoon | TCDD treatment(ug/kg):-	Collection Time:Afternoon | TCDD treatment(ug/kg):-	Collection Time:Afternoon | TCDD treatment(ug/kg):-	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	Collection Time:Afternoon | TCDD treatment(ug/kg):0.01	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	Collection Time:Afternoon | TCDD treatment(ug/kg):0.03	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	Collection Time:Afternoon | TCDD treatment(ug/kg):0.1	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	Collection Time:Afternoon | TCDD treatment(ug/kg):0.3	Collection Time:Afternoon | TCDD treatment(ug/kg):1	Collection Time:Afternoon | TCDD treatment(ug/kg):1	Collection Time:Afternoon | TCDD treatment(ug/kg):1	Collection Time:Afternoon | TCDD treatment(ug/kg):1	Collection Time:Afternoon | TCDD treatment(ug/kg):10	Collection Time:Afternoon | TCDD treatment(ug/kg):10	Collection Time:Afternoon | TCDD treatment(ug/kg):10	Collection Time:Afternoon | TCDD treatment(ug/kg):10	Collection Time:Afternoon | TCDD treatment(ug/kg):10	Collection Time:Afternoon | TCDD treatment(ug/kg):3	Collection Time:Afternoon | TCDD treatment(ug/kg):3	Collection Time:Afternoon | TCDD treatment(ug/kg):3	Collection Time:Afternoon | TCDD treatment(ug/kg):3	Collection Time:Afternoon | TCDD treatment(ug/kg):3	Collection Time:Afternoon | TCDD treatment(ug/kg):30	Collection Time:Afternoon | TCDD treatment(ug/kg):30	Collection Time:Afternoon | TCDD treatment(ug/kg):30	Collection Time:Morning | TCDD treatment(ug/kg):-	Collection Time:Morning | TCDD treatment(ug/kg):-	Collection Time:Morning | TCDD treatment(ug/kg):-	Collection Time:Morning | TCDD treatment(ug/kg):-	Collection Time:Morning | TCDD treatment(ug/kg):-	Collection Time:Morning | TCDD treatment(ug/kg):0.01	Collection Time:Morning | TCDD treatment(ug/kg):0.01	Collection Time:Morning | TCDD treatment(ug/kg):0.01	Collection Time:Morning | TCDD treatment(ug/kg):0.03	Collection Time:Morning | TCDD treatment(ug/kg):0.03	Collection Time:Morning | TCDD treatment(ug/kg):0.03	Collection Time:Morning | TCDD treatment(ug/kg):0.03	Collection Time:Morning | TCDD treatment(ug/kg):0.1	Collection Time:Morning | TCDD treatment(ug/kg):0.1	Collection Time:Morning | TCDD treatment(ug/kg):0.1	Collection Time:Morning | TCDD treatment(ug/kg):0.1	Collection Time:Morning | TCDD treatment(ug/kg):0.1	Collection Time:Morning | TCDD treatment(ug/kg):0.3	Collection Time:Morning | TCDD treatment(ug/kg):0.3	Collection Time:Morning | TCDD treatment(ug/kg):0.3	Collection Time:Morning | TCDD treatment(ug/kg):0.3	Collection Time:Morning | TCDD treatment(ug/kg):0.3	Collection Time:Morning | TCDD treatment(ug/kg):1	Collection Time:Morning | TCDD treatment(ug/kg):1	Collection Time:Morning | TCDD treatment(ug/kg):1	Collection Time:Morning | TCDD treatment(ug/kg):1	Collection Time:Morning | TCDD treatment(ug/kg):1	Collection Time:Morning | TCDD treatment(ug/kg):10	Collection Time:Morning | TCDD treatment(ug/kg):10	Collection Time:Morning | TCDD treatment(ug/kg):10	Collection Time:Morning | TCDD treatment(ug/kg):10	Collection Time:Morning | TCDD treatment(ug/kg):10	Collection Time:Morning | TCDD treatment(ug/kg):3	Collection Time:Morning | TCDD treatment(ug/kg):3	Collection Time:Morning | TCDD treatment(ug/kg):3	Collection Time:Morning | TCDD treatment(ug/kg):3	Collection Time:Morning | TCDD treatment(ug/kg):3	Collection Time:Morning | TCDD treatment(ug/kg):30	Collection Time:Morning | TCDD treatment(ug/kg):30	Collection Time:Morning | TCDD treatment(ug/kg):30	
acetyl-coa	2.2159	2.3828	1.5989	2.1954	2.4543	1.8728	2.6342	1.5160	1.4476	1.6000	1.1697	2.1707	1.9352	2.5440	2.0520	1.4957	1.6076	2.9079	2.7142	1.2730	3.6566	1.9934	3.8692	2.2475	2.3399	2.4181	1.2302	1.9557	1.5453	1.3701	0.8614	1.6225	1.1968	1.8670	2.0662	2.0846	0.6247	0.8056	0.5218	1.4942	2.4709	2.4694	3.1688	3.8684	1.6411	3.5639	3.0476	2.8214	2.1784	3.0725	3.1436	2.3040	1.6865	4.3636	2.6944	3.0662	3.2521	1.8382	3.5370	2.7930	2.0757	2.4859	1.6832	2.5705	2.4549	1.8792	2.3039	1.5166	2.0303	1.7782	2.2943	2.7691	1.8469	3.2190	3.2536	2.6261	0.8621	0.5414	0.7642
Coenzyme A	10.0808	7.0780	11.5181	6.2198	9.5884	11.7701	6.1272	11.6535	12.3824	10.1981	14.4735	7.8192	11.5014	14.9029	12.2803	10.1760	10.7999	10.6519	12.9513	14.1545	5.6500	11.7734	12.4498	7.8053	13.9706	11.1028	10.0897	11.5296	11.2133	13.0423	16.0554	8.0464	15.4303	10.0363	14.5289	10.7239	9.1508	8.4528	4.6657	6.0380	4.8281	8.4765	6.2538	15.9818	15.5446	13.1808	13.2219	11.4612	8.8322	18.3500	12.7409	10.8057	11.2232	9.5698	13.8333	13.4325	14.5539	14.5512	25.9182	22.2971	16.3554	22.4537	18.1612	18.2665	15.6190	13.0755	16.0141	26.2931	10.8778	17.1308	16.3902	17.0464	13.7223	13.8506	23.4316	19.6168	7.0923	3.6007	6.9959
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	pubchem_id	inchi_key	kegg_id	other_id	other_id_type	ri	ri_type	moverz_quant	
acetyl-coa	444493		C00024					809.126	
Coenzyme A	6816		C00010					767.115	
METABOLITES_END
#END