#METABOLOMICS WORKBENCH juliehaines_20210329_112445 DATATRACK_ID:2546 STUDY_ID:ST001735 ANALYSIS_ID:AN002825 PROJECT_ID:PR001110
VERSION             	1
CREATED_ON             	April 2, 2021, 5:47 am
#PROJECT
PR:PROJECT_TITLE                 	The COVIDome Explorer Researcher Portal (Red blood cells)
PR:PROJECT_SUMMARY               	COVID-19 pathology involves dysregulation of diverse molecular, cellular, and
PR:PROJECT_SUMMARY               	physiological processes. In order to expedite integrated and collaborative
PR:PROJECT_SUMMARY               	COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19
PR:PROJECT_SUMMARY               	patients including matched analysis of the whole blood transcriptome, plasma
PR:PROJECT_SUMMARY               	proteomics with two complementary platforms, cytokine profiling, plasma and red
PR:PROJECT_SUMMARY               	blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and
PR:PROJECT_SUMMARY               	clinical data annotation. We refer to this multidimensional dataset as the
PR:PROJECT_SUMMARY               	COVIDome. We then created the COVIDome Explorer, an online researcher portal
PR:PROJECT_SUMMARY               	where the data can be analyzed and visualized in real time. We illustrate here
PR:PROJECT_SUMMARY               	the use of the COVIDome dataset through a multi-omics analysis of biosignatures
PR:PROJECT_SUMMARY               	associated with C-reactive protein (CRP), an established marker of poor
PR:PROJECT_SUMMARY               	prognosis in COVID-19, revealing associations between CRP levels and
PR:PROJECT_SUMMARY               	damage-associated molecular patterns, depletion of protective serpins, and
PR:PROJECT_SUMMARY               	mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer
PR:PROJECT_SUMMARY               	will rapidly accelerate data sharing, hypothesis testing, and discoveries
PR:PROJECT_SUMMARY               	worldwide.
PR:INSTITUTE                     	University of Colorado Anschutz Medical Campus
PR:LAST_NAME                     	Haines
PR:FIRST_NAME                    	Julie
PR:ADDRESS                       	12801 E 17th Ave, Room 1303
PR:EMAIL                         	julie.haines@cuanschutz.edu
PR:PHONE                         	3037243339
#STUDY
ST:STUDY_TITLE                   	The COVIDome Explorer Researcher Portal (Red Blood Cells)
ST:STUDY_SUMMARY                 	COVID-19 pathology involves dysregulation of diverse molecular, cellular, and
ST:STUDY_SUMMARY                 	physiological processes. In order to expedite integrated and collaborative
ST:STUDY_SUMMARY                 	COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19
ST:STUDY_SUMMARY                 	patients including matched analysis of the whole blood transcriptome, plasma
ST:STUDY_SUMMARY                 	proteomics with two complementary platforms, cytokine profiling, plasma and red
ST:STUDY_SUMMARY                 	blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and
ST:STUDY_SUMMARY                 	clinical data annotation. We refer to this multidimensional dataset as the
ST:STUDY_SUMMARY                 	COVIDome. We then created the COVIDome Explorer, an online researcher portal
ST:STUDY_SUMMARY                 	where the data can be analyzed and visualized in real time. We illustrate here
ST:STUDY_SUMMARY                 	the use of the COVIDome dataset through a multi-omics analysis of biosignatures
ST:STUDY_SUMMARY                 	associated with C-reactive protein (CRP), an established marker of poor
ST:STUDY_SUMMARY                 	prognosis in COVID-19, revealing associations between CRP levels and
ST:STUDY_SUMMARY                 	damage-associated molecular patterns, depletion of protective serpins, and
ST:STUDY_SUMMARY                 	mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer
ST:STUDY_SUMMARY                 	will rapidly accelerate data sharing, hypothesis testing, and discoveries
ST:STUDY_SUMMARY                 	worldwide.
ST:INSTITUTE                     	University of Colorado Anschutz Medical Campus
ST:LAST_NAME                     	Haines
ST:FIRST_NAME                    	Julie
ST:ADDRESS                       	12801 E 17th Ave, Room 1303
ST:EMAIL                         	julie.haines@cuanschutz.edu
ST:PHONE                         	3037243339
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0001	COVID_Status:Positive | Sex:Male | Age:77	RAW_FILE_NAME=F2-03-39
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0002	COVID_Status:Positive | Sex:Female | Age:44	RAW_FILE_NAME=F2-03-74
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0003	COVID_Status:Positive | Sex:Female | Age:29	RAW_FILE_NAME=F2-03-28
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0004	COVID_Status:Negative | Sex:Male | Age:38	RAW_FILE_NAME=F2-03-115
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0005	COVID_Status:Positive | Sex:Male | Age:61	RAW_FILE_NAME=F2-03-36
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0006	COVID_Status:Negative | Sex:Female | Age:41	RAW_FILE_NAME=F2-03-35
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0007	COVID_Status:Positive | Sex:Male | Age:28	RAW_FILE_NAME=F2-03-113
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0008	COVID_Status:Positive | Sex:Female | Age:39	RAW_FILE_NAME=F2-03-02
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0009	COVID_Status:Positive | Sex:Female | Age:25	RAW_FILE_NAME=F2-03-19
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0010	COVID_Status:Positive | Sex:Male | Age:71	RAW_FILE_NAME=F2-03-03
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0011	COVID_Status:Positive | Sex:Male | Age:79	RAW_FILE_NAME=F2-03-30
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0012	COVID_Status:Positive | Sex:Male | Age:42	RAW_FILE_NAME=F2-03-112
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0013	COVID_Status:Positive | Sex:Male | Age:42	RAW_FILE_NAME=F2-03-07
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0014	COVID_Status:Positive | Sex:Female | Age:53	RAW_FILE_NAME=F2-03-87
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0016	COVID_Status:Positive | Sex:Male | Age:41	RAW_FILE_NAME=F2-03-55
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0017	COVID_Status:Negative | Sex:Female | Age:36	RAW_FILE_NAME=F2-03-70
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0018	COVID_Status:Positive | Sex:Female | Age:45	RAW_FILE_NAME=F2-03-22
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0019	COVID_Status:Positive | Sex:Female | Age:60	RAW_FILE_NAME=F2-03-82
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0020	COVID_Status:Positive | Sex:Male | Age:50	RAW_FILE_NAME=F2-03-31
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0021	COVID_Status:Positive | Sex:Male | Age:24	RAW_FILE_NAME=F2-03-56
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0022	COVID_Status:Positive | Sex:Female | Age:39	RAW_FILE_NAME=F2-03-92
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0023	COVID_Status:Negative | Sex:Male | Age:63	RAW_FILE_NAME=F2-03-25
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0024	COVID_Status:Positive | Sex:Female | Age:under 20	RAW_FILE_NAME=F2-03-09
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0025	COVID_Status:Positive | Sex:Female | Age:56	RAW_FILE_NAME=F2-03-78
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0026	COVID_Status:Positive | Sex:Female | Age:53	RAW_FILE_NAME=F2-03-34
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0027	COVID_Status:Negative | Sex:Female | Age:36	RAW_FILE_NAME=F2-03-40
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0028	COVID_Status:Negative | Sex:Female | Age:34	RAW_FILE_NAME=F2-03-47
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0029	COVID_Status:Positive | Sex:Male | Age:47	RAW_FILE_NAME=F2-03-77
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0030	COVID_Status:Positive | Sex:Male | Age:60	RAW_FILE_NAME=F2-03-13
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0031	COVID_Status:Negative | Sex:Male | Age:50	RAW_FILE_NAME=F2-03-42
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0033	COVID_Status:Positive | Sex:Female | Age:29	RAW_FILE_NAME=F2-03-80
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0035	COVID_Status:Positive | Sex:Female | Age:23	RAW_FILE_NAME=F2-03-103
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0036	COVID_Status:Positive | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-64
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0037	COVID_Status:Negative | Sex:Female | Age:30	RAW_FILE_NAME=F2-03-23
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0038	COVID_Status:Negative | Sex:Female | Age:39	RAW_FILE_NAME=F2-03-100
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0039	COVID_Status:Negative | Sex:Female | Age:38	RAW_FILE_NAME=F2-03-63
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0040	COVID_Status:Positive | Sex:Female | Age:61	RAW_FILE_NAME=F2-03-67
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0041	COVID_Status:Positive | Sex:Male | Age:33	RAW_FILE_NAME=F2-03-95
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0042	COVID_Status:Positive | Sex:Male | Age:55	RAW_FILE_NAME=F2-03-69
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0043	COVID_Status:Positive | Sex:Male | Age:21	RAW_FILE_NAME=F2-03-17
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0044	COVID_Status:Negative | Sex:Female | Age:80	RAW_FILE_NAME=F2-03-90
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0045	COVID_Status:Positive | Sex:Female | Age:46	RAW_FILE_NAME=F2-03-52
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0046	COVID_Status:Positive | Sex:Male | Age:54	RAW_FILE_NAME=F2-03-88
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0047	COVID_Status:Positive | Sex:Male | Age:59	RAW_FILE_NAME=F2-03-21
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0048	COVID_Status:Negative | Sex:Male | Age:60	RAW_FILE_NAME=F2-03-50
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0049	COVID_Status:Positive | Sex:Male | Age:50	RAW_FILE_NAME=F2-03-51
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0050	COVID_Status:Positive | Sex:Female | Age:under 20	RAW_FILE_NAME=F2-03-89
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0051	COVID_Status:Negative | Sex:Male | Age:42	RAW_FILE_NAME=F2-03-20
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0052	COVID_Status:Negative | Sex:Male | Age:43	RAW_FILE_NAME=F2-03-59
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0054	COVID_Status:Positive | Sex:Male | Age:46	RAW_FILE_NAME=F2-03-26
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0055	COVID_Status:Positive | Sex:Female | Age:54	RAW_FILE_NAME=F2-03-62
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0056	COVID_Status:Positive | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-32
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0057	COVID_Status:Positive | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-99
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0059	COVID_Status:Positive | Sex:Male | Age:55	RAW_FILE_NAME=F2-03-86
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0060	COVID_Status:Positive | Sex:Female | Age:38	RAW_FILE_NAME=F2-03-10
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0061	COVID_Status:Positive | Sex:Male | Age:51	RAW_FILE_NAME=F2-03-04
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0062	COVID_Status:Positive | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-61
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0063	COVID_Status:Negative | Sex:Female | Age:43	RAW_FILE_NAME=F2-03-68
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0064	COVID_Status:Negative | Sex:Male | Age:66	RAW_FILE_NAME=F2-03-45
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0065	COVID_Status:Positive | Sex:Male | Age:34	RAW_FILE_NAME=F2-03-12
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0066	COVID_Status:Positive | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-41
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0067	COVID_Status:Positive | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-107
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0068	COVID_Status:Positive | Sex:Male | Age:52	RAW_FILE_NAME=F2-03-24
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0069	COVID_Status:Positive | Sex:Female | Age:56	RAW_FILE_NAME=F2-03-76
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0070	COVID_Status:Positive | Sex:Male | Age:69	RAW_FILE_NAME=F2-03-118
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0071	COVID_Status:Positive | Sex:Female | Age:49	RAW_FILE_NAME=F2-03-14
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0072	COVID_Status:Negative | Sex:Male | Age:67	RAW_FILE_NAME=F2-03-54
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0073	COVID_Status:Negative | Sex:Male | Age:54	RAW_FILE_NAME=F2-03-83
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0074	COVID_Status:Positive | Sex:Female | Age:61	RAW_FILE_NAME=F2-03-81
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0075	COVID_Status:Positive | Sex:Female | Age:41	RAW_FILE_NAME=F2-03-75
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0076	COVID_Status:Negative | Sex:Male | Age:65	RAW_FILE_NAME=F2-03-33
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0077	COVID_Status:Positive | Sex:Female | Age:49	RAW_FILE_NAME=F2-03-94
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0078	COVID_Status:Positive | Sex:Female | Age:under 20	RAW_FILE_NAME=F2-03-38
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0079	COVID_Status:Negative | Sex:Female | Age:34	RAW_FILE_NAME=F2-03-58
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0080	COVID_Status:Positive | Sex:Female | Age:35	RAW_FILE_NAME=F2-03-105
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0081	COVID_Status:Negative | Sex:Male | Age:25	RAW_FILE_NAME=F2-03-43
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0082	COVID_Status:Negative | Sex:Male | Age:under 20	RAW_FILE_NAME=F2-03-98
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0083	COVID_Status:Negative | Sex:Male | Age:47	RAW_FILE_NAME=F2-03-72
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0084	COVID_Status:Negative | Sex:Male | Age:25	RAW_FILE_NAME=F2-03-84
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0085	COVID_Status:Positive | Sex:Female | Age:under 20	RAW_FILE_NAME=F2-03-104
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0086	COVID_Status:Negative | Sex:Male | Age:23	RAW_FILE_NAME=F2-03-110
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0087	COVID_Status:Positive | Sex:Female | Age:21	RAW_FILE_NAME=F2-03-01
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0088	COVID_Status:Positive | Sex:Female | Age:under 20	RAW_FILE_NAME=F2-03-91
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0089	COVID_Status:Positive | Sex:Male | Age:60	RAW_FILE_NAME=F2-03-97
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0090	COVID_Status:Positive | Sex:Female | Age:43	RAW_FILE_NAME=F2-03-37
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0091	COVID_Status:Negative | Sex:Male | Age:35	RAW_FILE_NAME=F2-03-79
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0092	COVID_Status:Positive | Sex:Female | Age:under 20	RAW_FILE_NAME=F2-03-29
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0093	COVID_Status:Negative | Sex:Male | Age:26	RAW_FILE_NAME=F2-03-08
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0094	COVID_Status:Negative | Sex:Female | Age:31	RAW_FILE_NAME=F2-03-117
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0095	COVID_Status:Negative | Sex:Female | Age:76	RAW_FILE_NAME=F2-03-16
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0096	COVID_Status:Positive | Sex:Male | Age:43	RAW_FILE_NAME=F2-03-11
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0097	COVID_Status:Negative | Sex:Male | Age:71	RAW_FILE_NAME=F2-03-66
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0098	COVID_Status:Positive | Sex:Male | Age:61	RAW_FILE_NAME=F2-03-116
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0100	COVID_Status:Positive | Sex:Female | Age:23	RAW_FILE_NAME=F2-03-27
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0101	COVID_Status:Positive | Sex:Male | Age:20	RAW_FILE_NAME=F2-03-49
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0102	COVID_Status:Positive | Sex:Female | Age:57	RAW_FILE_NAME=F2-03-109
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0104	COVID_Status:Positive | Sex:Male | Age:79	RAW_FILE_NAME=F2-03-85
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0105	COVID_Status:Negative | Sex:Male | Age:59	RAW_FILE_NAME=F2-03-101
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0106	COVID_Status:Positive | Sex:Female | Age:21	RAW_FILE_NAME=F2-03-122
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0107	COVID_Status:Positive | Sex:Male | Age:26	RAW_FILE_NAME=F2-03-120
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0108	COVID_Status:Positive | Sex:Male | Age:45	RAW_FILE_NAME=F2-03-121
SUBJECT_SAMPLE_FACTORS           	-	CUcovID_0109	COVID_Status:Positive | Sex:Male | Age:30	RAW_FILE_NAME=F2-03-119
#COLLECTION
CO:COLLECTION_SUMMARY            	Study design, participant recruitment, and clinical data capture. Research
CO:COLLECTION_SUMMARY            	participants were recruited and consented for participation in the COVID Biobank
CO:COLLECTION_SUMMARY            	of the University of Colorado Anschutz Medical Campus [Colorado Multiple
CO:COLLECTION_SUMMARY            	Institutional Review Board (COMIRB) Protocol # 20-0685]. Data was generated from
CO:COLLECTION_SUMMARY            	deidentified biospecimens and linked to demographics and clinical metadata
CO:COLLECTION_SUMMARY            	procured through the Health Data Compass of the University of Colorado under
CO:COLLECTION_SUMMARY            	COMIRB Protocol # 20-1700. Participants were hospitalized either at Children’s
CO:COLLECTION_SUMMARY            	Hospital Colorado or the University of Colorado Hospital. COVID-19 status was
CO:COLLECTION_SUMMARY            	defined by a positive PCR reaction and/or antibody test. Cohort characteristics
CO:COLLECTION_SUMMARY            	can be found in Supp. File 1. METHOD DETAILS. Blood processing. Blood samples
CO:COLLECTION_SUMMARY            	were collected into EDTA tubes, PAXgene RNA, and sodium heparin tubes. After
CO:COLLECTION_SUMMARY            	centrifugation, EDTA plasma was used for MS proteomics, SOMAscan® proteomics,
CO:COLLECTION_SUMMARY            	as well as multiplex immunoassays using MSD technology for both cytokine
CO:COLLECTION_SUMMARY            	profiles and seroconversion assays. From sodium heparin tubes, PBMCs were
CO:COLLECTION_SUMMARY            	obtained by the Ficoll gradient method before cryopreservation and assembly of
CO:COLLECTION_SUMMARY            	batches for MC analysis.
CO:SAMPLE_TYPE                   	Red blood cells
#TREATMENT
TR:TREATMENT_SUMMARY             	n/a
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Samples were thawed on ice and extracted via a modified Folch method
SP:SAMPLEPREP_SUMMARY            	(chloroform/methanol/water 8:4:3), which completely inactivates other
SP:SAMPLEPREP_SUMMARY            	coronaviruses, such as MERS-CoV. Briefly, 20 μL of sample was diluted in 130
SP:SAMPLEPREP_SUMMARY            	μL of LC-MS grade water, 600 μL of ice-cold chloroform/methanol (2:1) was
SP:SAMPLEPREP_SUMMARY            	added, and the samples were vortexed for 10 seconds. Samples were then incubated
SP:SAMPLEPREP_SUMMARY            	at 4°C for 5 minutes, quickly vortexed (5 seconds), and centrifuged at 14,000 g
SP:SAMPLEPREP_SUMMARY            	for 10 minutes at 4°C. The top (i.e., aqueous) phase was transferred to a new
SP:SAMPLEPREP_SUMMARY            	tube for metabolomics analysis and flash frozen. The bottom (i.e., organic)
SP:SAMPLEPREP_SUMMARY            	phase was transferred to a new tube for lipidomics analysis, then dried under N2
SP:SAMPLEPREP_SUMMARY            	flow. UHPLC-MS metabolomics. Analyses were performed using a Vanquish UHPLC
SP:SAMPLEPREP_SUMMARY            	coupled online to a Q Exactive high resolution mass spectrometer (Thermo Fisher
SP:SAMPLEPREP_SUMMARY            	Scientific, Bremen, Germany). Samples (10 uL per injection) were randomized and
SP:SAMPLEPREP_SUMMARY            	analyzed in positive and negative electrospray ionization modes (separate runs)
SP:SAMPLEPREP_SUMMARY            	using a 5-minute C18 gradient on a Kinetex C18 column (Phenomenex) as described
SP:SAMPLEPREP_SUMMARY            	(Nemkov et al., 2019). Data were analyzed using Maven (Princeton University,
SP:SAMPLEPREP_SUMMARY            	Princeton, NJ, USA) in conjunction with the KEGG database and an in-house
SP:SAMPLEPREP_SUMMARY            	standard library.
SP:PROCESSING_STORAGE_CONDITIONS 	4℃
SP:EXTRACT_STORAGE               	-80℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	After sample randomization, 10 μL of extracts were injected into a Thermo
CH:CHROMATOGRAPHY_SUMMARY        	Vanquish UHPLC system (San Jose, CA, USA) and resolved on a Kinetex C18 column
CH:CHROMATOGRAPHY_SUMMARY        	(150 × 2.1 mm, 1.7 μm, Phenomenex, Torrance, CA, USA) at 450 μL/min through a
CH:CHROMATOGRAPHY_SUMMARY        	5 min gradient from 0 to 100% phase B (phase A was 5% acetonitrile, 95% water, 1
CH:CHROMATOGRAPHY_SUMMARY        	mM ammonium acetate, phase B was 95% acetonitrile, 5% water, 0.5 mM ammonium
CH:CHROMATOGRAPHY_SUMMARY        	acetate). Solvent gradient: 0-0.5 min 0% B; 0.5-1.1 min 0-100% B, 1.1-2.75 min
CH:CHROMATOGRAPHY_SUMMARY        	hold at 100% B, 2.75-3 min 100-0% B, 3-5 min hold at 0% B.
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Vanquish
CH:COLUMN_NAME                   	Phenomenex Kinetex C18 2.1 x 150 mm, 1.7 um
CH:FLOW_RATE                     	450 uL/min
CH:COLUMN_TEMPERATURE            	45
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	Resolution 70,000, scan range 65-900 m/z, maximum injection time 200 ms,
MS:MS_COMMENTS                   	microscans 2, automatic gain control (AGC) 3 x 10^6 ions, source voltage 4.0 kV,
MS:MS_COMMENTS                   	capillary temperature 320 C, and sheath gas 45, auxiliary gas 15, and sweep gas
MS:MS_COMMENTS                   	0 (all nitrogen).
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	peak area
MS_METABOLITE_DATA_START
Samples	CUcovID_0043	CUcovID_0067	CUcovID_0092	CUcovID_0085	CUcovID_0101	CUcovID_0057	CUcovID_0026	CUcovID_0052	CUcovID_0098	CUcovID_0049	CUcovID_0039	CUcovID_0087	CUcovID_0047	CUcovID_0070	CUcovID_0089	CUcovID_0002	CUcovID_0084	CUcovID_0035	CUcovID_0088	CUcovID_0024	CUcovID_0056	CUcovID_0082	CUcovID_0081	CUcovID_0086	CUcovID_0062	CUcovID_0031	CUcovID_0095	CUcovID_0019	CUcovID_0102	CUcovID_0045	CUcovID_0003	CUcovID_0090	CUcovID_0096	CUcovID_0011	CUcovID_0046	CUcovID_0080	CUcovID_0071	CUcovID_0009	CUcovID_0059	CUcovID_0018	CUcovID_0029	CUcovID_0077	CUcovID_0065	CUcovID_0012	CUcovID_0041	CUcovID_0040	CUcovID_0075	CUcovID_0072	CUcovID_0063	CUcovID_0069	CUcovID_0028	CUcovID_0105	CUcovID_0022	CUcovID_0091	CUcovID_0083	CUcovID_0079	CUcovID_0021	CUcovID_0038	CUcovID_0093	CUcovID_0094	CUcovID_0006	CUcovID_0017	CUcovID_0044	CUcovID_0073	CUcovID_0023	CUcovID_0027	CUcovID_0097	CUcovID_0037	CUcovID_0048	CUcovID_0025	CUcovID_0076	CUcovID_0036	CUcovID_0066	CUcovID_0050	CUcovID_0078	CUcovID_0054	CUcovID_0109	CUcovID_0064	CUcovID_0014	CUcovID_0068	CUcovID_0030	CUcovID_0074	CUcovID_0061	CUcovID_0106	CUcovID_0100	CUcovID_0051	CUcovID_0008	CUcovID_0055	CUcovID_0016	CUcovID_0042	CUcovID_0020	CUcovID_0104	CUcovID_0033	CUcovID_0013	CUcovID_0108	CUcovID_0010	CUcovID_0005	CUcovID_0001	CUcovID_0007	CUcovID_0060	CUcovID_0004	CUcovID_0107
Factors	COVID_Status:Positive | Sex:Male | Age:21	COVID_Status:Positive | Sex:Male | Age:under 20	COVID_Status:Positive | Sex:Female | Age:under 20	COVID_Status:Positive | Sex:Female | Age:under 20	COVID_Status:Positive | Sex:Male | Age:20	COVID_Status:Positive | Sex:Male | Age:under 20	COVID_Status:Positive | Sex:Female | Age:53	COVID_Status:Negative | Sex:Male | Age:43	COVID_Status:Positive | Sex:Male | Age:61	COVID_Status:Positive | Sex:Male | Age:50	COVID_Status:Negative | Sex:Female | Age:38	COVID_Status:Positive | Sex:Female | Age:21	COVID_Status:Positive | Sex:Male | Age:59	COVID_Status:Positive | Sex:Male | Age:69	COVID_Status:Positive | Sex:Male | Age:60	COVID_Status:Positive | Sex:Female | Age:44	COVID_Status:Negative | Sex:Male | Age:25	COVID_Status:Positive | Sex:Female | Age:23	COVID_Status:Positive | Sex:Female | Age:under 20	COVID_Status:Positive | Sex:Female | Age:under 20	COVID_Status:Positive | Sex:Male | Age:under 20	COVID_Status:Negative | Sex:Male | Age:under 20	COVID_Status:Negative | Sex:Male | Age:25	COVID_Status:Negative | Sex:Male | Age:23	COVID_Status:Positive | Sex:Male | Age:under 20	COVID_Status:Negative | Sex:Male | Age:50	COVID_Status:Negative | Sex:Female | Age:76	COVID_Status:Positive | Sex:Female | Age:60	COVID_Status:Positive | Sex:Female | Age:57	COVID_Status:Positive | Sex:Female | Age:46	COVID_Status:Positive | Sex:Female | Age:29	COVID_Status:Positive | Sex:Female | Age:43	COVID_Status:Positive | Sex:Male | Age:43	COVID_Status:Positive | Sex:Male | Age:79	COVID_Status:Positive | Sex:Male | Age:54	COVID_Status:Positive | Sex:Female | Age:35	COVID_Status:Positive | Sex:Female | Age:49	COVID_Status:Positive | Sex:Female | Age:25	COVID_Status:Positive | Sex:Male | Age:55	COVID_Status:Positive | Sex:Female | Age:45	COVID_Status:Positive | Sex:Male | Age:47	COVID_Status:Positive | Sex:Female | Age:49	COVID_Status:Positive | Sex:Male | Age:34	COVID_Status:Positive | Sex:Male | Age:42	COVID_Status:Positive | Sex:Male | Age:33	COVID_Status:Positive | Sex:Female | Age:61	COVID_Status:Positive | Sex:Female | Age:41	COVID_Status:Negative | Sex:Male | Age:67	COVID_Status:Negative | Sex:Female | Age:43	COVID_Status:Positive | Sex:Female | Age:56	COVID_Status:Negative | Sex:Female | Age:34	COVID_Status:Negative | Sex:Male | Age:59	COVID_Status:Positive | Sex:Female | Age:39	COVID_Status:Negative | Sex:Male | Age:35	COVID_Status:Negative | Sex:Male | Age:47	COVID_Status:Negative | Sex:Female | Age:34	COVID_Status:Positive | Sex:Male | Age:24	COVID_Status:Negative | Sex:Female | Age:39	COVID_Status:Negative | Sex:Male | Age:26	COVID_Status:Negative | Sex:Female | Age:31	COVID_Status:Negative | Sex:Female | Age:41	COVID_Status:Negative | Sex:Female | Age:36	COVID_Status:Negative | Sex:Female | Age:80	COVID_Status:Negative | Sex:Male | Age:54	COVID_Status:Negative | Sex:Male | Age:63	COVID_Status:Negative | Sex:Female | Age:36	COVID_Status:Negative | Sex:Male | Age:71	COVID_Status:Negative | Sex:Female | Age:30	COVID_Status:Negative | Sex:Male | Age:60	COVID_Status:Positive | Sex:Female | Age:56	COVID_Status:Negative | Sex:Male | Age:65	COVID_Status:Positive | Sex:Male | Age:under 20	COVID_Status:Positive | Sex:Male | Age:under 20	COVID_Status:Positive | Sex:Female | Age:under 20	COVID_Status:Positive | Sex:Female | Age:under 20	COVID_Status:Positive | Sex:Male | Age:46	COVID_Status:Positive | Sex:Male | Age:30	COVID_Status:Negative | Sex:Male | Age:66	COVID_Status:Positive | Sex:Female | Age:53	COVID_Status:Positive | Sex:Male | Age:52	COVID_Status:Positive | Sex:Male | Age:60	COVID_Status:Positive | Sex:Female | Age:61	COVID_Status:Positive | Sex:Male | Age:51	COVID_Status:Positive | Sex:Female | Age:21	COVID_Status:Positive | Sex:Female | Age:23	COVID_Status:Negative | Sex:Male | Age:42	COVID_Status:Positive | Sex:Female | Age:39	COVID_Status:Positive | Sex:Female | Age:54	COVID_Status:Positive | Sex:Male | Age:41	COVID_Status:Positive | Sex:Male | Age:55	COVID_Status:Positive | Sex:Male | Age:50	COVID_Status:Positive | Sex:Male | Age:79	COVID_Status:Positive | Sex:Female | Age:29	COVID_Status:Positive | Sex:Male | Age:42	COVID_Status:Positive | Sex:Male | Age:45	COVID_Status:Positive | Sex:Male | Age:71	COVID_Status:Positive | Sex:Male | Age:61	COVID_Status:Positive | Sex:Male | Age:77	COVID_Status:Positive | Sex:Male | Age:28	COVID_Status:Positive | Sex:Female | Age:38	COVID_Status:Negative | Sex:Male | Age:38	COVID_Status:Positive | Sex:Male | Age:26
ATP	44651	9157974	24210	7421754	76087	5879048	8821703	3540694	12569720	437165	324887	1998393	43979	4108544	10807840	178858	1510240	11730120	3637527	80565	88966	7915616	5519380	16165900	4748594	2500483	293586	556801	1901325	6374604	249143	81078	9900920	381594	115410	8163862	2002886	3848320	1496856	119576	1029337	389113	3582278	8183506	5096256	433466	235279	8276140	49506	13431460	65893	6800506	114418	521260	2274739	194574	906901	8901408	3945060	3031420	1506348	1902535	9198381	1813548	371890	138161	2846882	40388	261844	79652	648624	390936	8495061	6598752	40695	130426	6417768	334859	237446	924361	209053	4862820	1646474	10380820	117582	181014	4096522	112280	20475	116822	136036	845300	60199	8555309	9843708	6146242	110724	91494	11690620	2026797	2688350	11054890
ADP	977312	20622710	2165013	21310310	2732562	21207570	38925300	10254240	21427410	6095016	3739124	10799310	2528695	21092260	26091960	3324727	11204410	28310850	14396310	2488102	1840643	19655050	20952820	26890170	24322810	13723620	5023378	5478114	11670920	15921340	3884144	1345211	32635380	4543246	3318694	27482650	15480600	13218930	7820112	2913123	8242764	4744534	16701630	20195380	20582370	6716676	3762905	17097180	2193067	29159540	1486750	22192440	1225808	5268144	12640810	3726937	5339284	21599080	10117170	14079330	6340294	11593800	20209480	11328480	3078713	1324919	10283270	1584638	4339038	1619819	7863402	4290740	22654540	13842690	1821793	2639708	18829600	5936672	4360176	7866110	4684836	12539110	12300230	18453580	3361434	2857391	16082220	2285547	1883258	3084730	3361511	8202502	1613591	23673370	24710510	17055760	3131607	1871856	23013380	14210230	13189480	27812300
AMP	38518880	18733680	76661830	20164510	69809700	8829395	4026521	8459827	1689279	63734430	29434860	20218110	71925480	39251960	11246110	48497900	73531580	3740812	34297370	98468900	83844150	14338660	8774817	23324500	74964160	31105320	86919380	43559070	37099810	4046613	57442700	17563310	4226396	33828620	84104430	52875460	66808840	36079900	30735030	69311850	55919570	37007290	44140220	35629080	29934360	65688710	67898750	4603801	49050550	2006922	53654000	26075430	11035910	43721510	52785790	77191500	21632350	28866860	4021359	44925870	12554740	75980380	2853852	50175800	29299270	8426178	14881720	32429030	71833660	41382400	62532690	41644440	6176854	4588520	72622360	56627440	10515220	68772650	81046530	61753700	86720340	6166528	67136420	2632137	55177610	36470060	40597320	41941180	78449700	53115720	64481080	65802700	68312620	8571203	12749260	11275360	71462280	31528090	6845332	70738550	25173450	28248190
dAMP	87894	66313	122879	37074	190204	15714	5029	4874	30898	184253	137493	59769	90586	10790	17812	189543	119500	27292	64857	15097	118636	13875	31957	32692	54253	52090	102551	86606	11187	9453	175317	93436	9858	29325	90471	26987	78233	140783	4964	39982	27010	101327	52479	34325	31013	120647	124304	15748	263076	8945	159731	21888	200676	342261	99260	307299	58194	68988	11392	48391	51370	85406	38394	45293	144516	168283	28231	86083	208093	131457	336596	61516	5648	27562	72489	65434	29295	141440	78726	43470	97830	24347	43912	68396	125183	201538	44992	231383	125079	55521	20856	27012	52775	24653	40280	54277	33227	164991	21846	101709	11195	28012
GDP	374095	1422644	283965	1306186	463912	998738	1740758	788436	904411	395134	440029	352651	320316	883162	1621593	311708	638269	1022251	471758	257989	251768	892683	923945	1104783	971916	595804	465944	449031	899952	1040135	444227	813025	1134266	487838	325226	872091	819056	780583	575075	460815	317808	603257	1270791	761792	815059	503858	540965	640136	292631	1321952	407178	750053	609895	502750	626776	398437	404426	830979	1225190	947426	895050	391196	676227	735666	603535	826691	1144404	345288	445391	189137	761138	318800	884225	405049	359555	330909	831696	442824	348730	570829	373003	315001	527328	920567	287471	368427	711550	417833	306134	344061	232146	535227	237968	1269738	778452	832304	347401	344691	774100	602808	978076	658035
Cytidine	101422	105453	86056	129389	125420	119547	247083	292685	118842	56580	98031	58210	74318	100074	249571	50800	111977	233633	83446	65395	111960	312382	184969	103772	133311	116126	91835	68194	263027	233486	70385	65613	165820	160313	79190	98466	282575	70431	77047	140691	72349	202927	88370	71699	123051	93963	83301	256254	53568	198509	104949	100631	96094	199902	172239	62495	101654	88437	242187	80572	189471	126286	163688	378969	100537	165627	152960	65619	62319	54473	97312	117943	148107	139565	78861	172673	103120	45097	59107	164431	93318	112364	94629	145745	49840	85648	265677	87772	99101	107013	121191	58994	42988	211806	115653	340645	99828	75624	170885	50946	780597	185736
UDP	193543	164271	56022	346712	258707	201057	209232	525136	588842	142800	197680	246859	181123	156152	191824	139800	77971	663446	107776	41835	36075	676008	98832	40990	156904	151408	104776	239380	126420	230104	97215	209493	108136	214900	162779	80627	102617	81334	101331	179551	255247	273462	144274	46532	38241	112354	95668	488076	202830	241316	83297	28843	326842	91682	108155	70695	81345	60459	42774	129252	84372	21408	194892	71144	146855	220603	200260	76965	107706	69893	99858	490578	120468	476716	62420	160032	753884	108674	119250	127203	80513	206746	143664	751226	81144	274876	109321	255769	135538	208139	201888	79855	166491	344963	601570	399733	83993	188285	145434	109089	137936	170508
UMP	19943	98214	31500	40938	9721	28857	44374	71668	14559	109860	92764	18445	15803	14267	60785	52572	17316	14106	21796	61574	3194	58713	23182	476	65291	41691	66679	149065	104817	26432	67808	27553	14741	137592	59646	8704	23680	83280	97570	76086	63397	243234	60427	59113	14457	33808	9903	27730	108167	1001	75472	18229	112582	133189	100178	56564	264713	94025	87777	93779	180897	69145	13776	14539	93911	93968	197710	15728	71463	56270	23000	60345	16715	31550	9107	130955	26318	122446	65227	91731	132878	45418	66667	77131	11180	315941	135493	109644	17463	237110	21737	79035	10512	21520	42814	101119	82914	42552	13741	99679	114309	49904
Uracil	202643	203170	90580	148898	136795	95909	133270	110335	110309	229019	205863	105544	143394	145619	131453	129441	174430	194957	128014	137598	125140	190484	161428	101285	112185	143500	127282	118168	184687	150920	108865	138885	134730	117588	90292	135221	184349	162504	86793	97249	118858	130856	146478	148739	110981	131104	108059	184404	166205	200167	223709	105397	265405	163578	167264	240539	117498	138204	184294	170814	200160	98266	193567	108262	1304784	192829	176916	87649	154423	125923	291410	113577	157542	153253	102248	133844	132976	100659	149667	146766	128370	106338	88174	152968	134057	182058	112945	156494	252740	115132	123602	164225	122582	126729	951209	155795	110442	127031	178611	167228	143329	132718
IDP	592761	568351	503995	780069	1488561	258924	908811	837714	1420539	2679452	1237965	404796	6335758	590344	318200	700310	804450	929840	1699242	670535	430820	571316	794452	396401	1016764	1107641	1535990	1225740	539780	812100	1572162	1488078	675763	1275848	792144	245087	1491659	1687937	1116226	1550954	868682	1751961	2682586	1052092	1164515	728183	699219	2149889	2036852	498607	1467719	253275	1350178	983101	2520647	418962	2526024	1497109	980508	793788	1533249	1575739	1600302	354938	2470294	1316933	904310	972534	1957243	679592	2943097	1498387	1268153	2819404	560864	1301809	684607	1662054	1984716	1569069	925888	2479466	1368702	1255708	797317	2360885	1573034	896142	431328	1033100	1574565	292955	764408	1220095	1324741	2099093	753570	1576165	1010139	3425085	720586	1982954
IMP	14119360	44241120	4868014	16458560	4223362	7229232	11545900	18950120	6513826	24254210	55304120	3287833	7394600	5150338	9287729	15674620	10631430	12794170	21633440	9953892	2076581	15909520	13144500	1556006	5015596	8754708	6212306	40692660	15141470	3648268	26853590	21803670	13182090	24227170	6659640	3931254	16025750	13436990	25999920	17225560	9129235	33559020	12108440	5654822	10846200	6233392	12830980	20734250	48495570	25488020	41214180	9782419	43704610	37192630	21678280	20387650	49387830	14974000	41412440	13275260	33212150	4385190	9441265	1581093	53974240	34048060	20896650	16107580	26159670	22905670	15887460	42948200	15590060	35955680	2085649	38363180	19546400	6991972	12742020	17411350	7783098	23257310	8946371	21058190	6521382	44836710	5939724	29011680	32250080	21590540	9485234	24947940	19348150	42059410	7073988	29820590	22181880	34639050	4065227	11533380	15283000	5538314
Inosine	889179	606687	940428	881941	203201	773103	364681	401731	293431	376262	869126	279276	717041	403321	438733	486389	1250106	381976	756969	235485	449687	384069	608022	603367	520788	432609	415250	736052	275783	2152809	399235	412051	423577	913844	687001	1022446	489210	319400	881396	1748614	655767	682296	302407	361408	307582	548904	1610439	372958	541292	281072	412238	351370	751232	693976	550760	361949	948722	196114	558278	2306221	317421	224522	201457	971723	549935	1190844	1428767	427809	341062	549113	556267	974664	242443	1294752	405330	582589	661394	298952	559302	552922	711199	486159	671015	219854	432805	549515	533331	473423	520977	904314	673427	519816	723115	649520	240820	649026	690849	663747	1589773	2261632	354437	1257264
5-6-Dihydrothymine	1241674	1682600	1008352	1112274	3144735	1029636	586518	600351	831216	1017816	1044094	845567	668466	762437	1017318	751736	655423	1269857	960970	1156210	919249	2482839	1654789	1245270	912739	1382584	730756	446859	1449391	1032185	829743	1976270	821004	961747	1041167	900813	1078012	656047	197099	865811	760077	782520	908027	1038928	705263	1366809	1112965	982678	1082407	935470	1583283	704367	1992480	689325	649239	668049	673998	1081551	1007609	1006578	1102248	1007198	942756	1279910	1451931	1630448	1283609	982179	1143170	609101	902588	487249	663081	297413	1426433	597145	920294	1941931	617897	487583	585312	1053312	912346	1098790	1219253	1086775	1527608	624182	547069	785920	900282	894736	790207	796498	781254	887663	729016	745692	837241	1325815	1375524	1043590
4-Pyridoxate	10282	11748	4314	8507	7173	2186	0	3561	18686	12137	9693	6581	8135	6335	11099	8936	11189	15036	7936	16087	15808	11816	10213	10457	7254	11428	14345	10580	8404	6560	11049	5241	7024	0	11258	7446	8135	13835	7631	4951	9488	11361	11928	16215	11480	13610	4175	19320	4468	28094	8597	14490	5377	50227	10639	118400	18572	11129	52811	2822	26108	15268	34035	6857	21592	15543	17178	5883	10943	4835	17977	10038	12693	6518	0	7905	4237	1767	6371	8765	7394	13467	8286	21942	3787	18601	10559	16740	7211	5836	4524	6527	6637	3624	0	200101	6165	6714	2722	7098	11476	12717
UDP-glucose	763392	560544	844399	464875	416614	442677	383724	276512	429217	589557	509672	349467	793388	471795	1033016	427109	875105	567027	701169	764181	606744	698642	533915	650352	1144361	517678	778026	557708	858347	729178	575020	528914	577366	671371	712001	630264	606671	503058	817488	702082	411376	731711	574756	514232	514577	825340	598736	491247	744313	355084	715252	595129	735159	590414	613502	690983	662322	631795	450044	741237	537856	795471	416865	740765	815659	630272	927951	1002528	740732	636166	622642	469428	519515	554594	687005	573720	377083	592790	723995	732904	650375	487473	462711	462621	604914	598362	664175	661390	934409	694198	509188	626212	528371	545616	554610	421682	716404	636238	746745	577068	643142	515827
Phosphate	66063070	50193690	86790310	33469100	80664990	26855920	60455960	20383570	39324160	95076350	68716680	34960440	84553190	50866600	28427780	61444110	61293610	37307360	54991710	92066780	73719910	44042260	40919560	35715640	92974890	57871170	91443770	85486400	53325470	47677570	77923790	57253570	39882850	80385030	71863140	49566190	76163590	80921080	100049100	99698880	59485250	91315010	97338840	60841690	48163930	63028370	68990150	57608960	99881480	30595160	79913820	45201040	71900560	102803600	89869270	71156070	96047580	75002620	40283570	55094480	76504310	76365620	55941720	58055350	75381420	66010060	64476800	60804680	104861400	67641820	92137980	67492420	49755960	72420890	81593520	108130600	29879570	98107130	100950100	103215900	93620800	72679610	81047450	48866100	72110750	87073920	82072830	68454550	81067360	62521760	73715360	88630690	83182440	63374020	55126720	59531670	105160700	77571810	50860980	94361660	47834400	65384410
Diphosphate	3505592	2632277	5074828	2801842	5105508	2083648	2541838	1830370	1901935	8038164	2921213	1806504	5804378	2510761	3448540	3143140	2500228	2177945	2065189	6384766	5068156	2779070	2058974	1892176	6452552	2802510	7041290	4670434	3516024	3559298	3839159	2790468	2409657	3932711	3391191	3378532	3915531	5841242	11237810	6124492	3483371	4536372	8649877	3950856	2404746	3000217	3272014	2728978	8281878	2716567	4579472	2507385	4065824	9753101	6781520	4035766	7508046	4619104	1688395	2890737	4628932	7445192	3123222	3445151	3509330	2843025	3789685	3159432	8253948	4430024	5168180	3148058	2131731	4154310	5515968	9242644	2183420	9259582	9798665	8474433	6775086	4067921	5904650	2405262	4818614	5728056	4853516	3476825	4884244	3531860	5961522	6138108	5852576	2421238	2805297	2566983	8308292	4290060	2758500	6373596	3106382	3103177
D-Glucose	4055948	3502720	19637470	8073072	10843460	3481682	16281700	5808298	7513340	8772591	6437906	4502310	6805146	13571790	12356850	7294582	9230487	8841064	6403390	8869316	7697096	4768316	9065811	7028112	10418770	10985480	10729780	1682263	8556444	1350626	5685886	27133340	12376800	5277694	8094118	5049394	10229120	4425216	9132541	6266214	8296228	17483160	2968821	5413608	10330510	5078768	7504952	11825030	9051927	12154120	8502803	32505340	4899208	3049119	14424190	12175380	1928441	4179143	11394270	7299154	20364130	5215400	6980094	8647509	5686342	7095310	7925336	9009545	7584048	4015831	16063870	6090438	9128185	9533788	5965262	1499645	7110282	4786972	11644140	29164690	9119488	27492080	5936798	3516751	12221500	4908614	6066272	8487140	17239960	18833270	15510040	4766344	5155274	8706255	2780850	10598540	4952642	12267260	12543740	19204670	2460327	2447098
Hexose phosphate	5311506	4517440	2990390	3605960	2223669	6585306	2454120	1295281	1450833	1744546	2116709	2071328	2885081	2947824	5059572	2111942	2863420	2152311	2730741	3402316	2197756	4673825	1942671	2669974	3046020	3050395	2073401	2453521	5436968	4084616	2196736	1887104	2061628	2892871	4896398	4750282	4335642	2343670	2775857	3965016	2268562	2681538	2095794	2665249	3028955	4118697	3339061	2187380	2157068	2355797	3513057	3836120	2887519	1839928	1879899	3649648	2185411	3025717	2427766	2529733	3641844	1334675	1565992	2805322	1855848	3535355	6081690	2604630	3614748	2259443	2343296	2909120	1709405	2667214	2850331	2195653	2187657	1949321	2163178	3239670	3777488	2717924	3004348	2474820	2104874	1691564	3635093	4310214	4959880	3835919	2262963	2987606	2652562	3466020	2361581	2020458	2090153	2038400	5310254	3380043	4391986	2963762
D-Fructose 1-6-bisphosphate	25944310	9640429	12863680	9573996	8687693	11111940	5370076	5688612	7235014	7423138	14481940	6418920	15196620	7881026	12913380	10331660	17569960	7897498	9283837	17278140	10525510	9204099	7643370	10805080	14067770	7259500	11134250	14539300	11921370	14320330	13213720	7557726	10344370	12516540	16652490	17155160	22763480	15174600	7344376	22007090	11869340	14869650	8563393	10074390	10163850	18024070	11484320	8591928	9666805	7297648	11749260	7977868	14105100	12809000	7960316	24316660	13622860	11268360	10136320	10296360	12820130	7567468	6448916	8676714	9842072	16738520	11905730	10082110	17720550	8983556	8641439	17840790	7922336	9383348	10306700	14046750	7382628	7991598	11513860	17228430	15907870	9459859	10000290	9342875	7935002	8888896	22855490	17648330	24392030	13111220	10263540	14719600	14094660	20334450	7332140	9136525	11259710	9444037	10832050	21292460	13252020	11519610
D-Glyceraldehyde 3-phosphate/Glycerone phosphate	19214710	6972598	13770200	8433321	9600439	4002241	4975154	5900298	1401302	7897450	15664540	4165891	13916490	7306246	5817732	11144150	18311860	3533747	16690420	13168360	7258886	11789450	8640925	3419964	11270280	9917939	9536153	16921920	13844380	3152844	16045620	10771910	4379996	15055680	19650550	9515876	18104210	6956776	3360131	16981990	10380710	20018800	2196080	6198364	14398240	20652550	17640930	4496788	7877204	5017760	18803560	7278140	21317890	2141369	9800233	19070990	9668921	7703814	13062220	10880580	13443000	5531866	2277936	5257994	15976470	21045970	3348106	11953850	13621480	10116380	11191660	15342320	5550980	7165068	13366880	11182810	7980980	4483500	6382610	11131050	10686970	7300314	3814867	5106390	7638370	9761466	11497840	18819010	16662000	17052020	9873409	16515980	12720060	13098010	3734697	10422260	9233175	14214840	2542594	13524970	14169600	7356228
1-3-Bisphosphoglycerate	517898800	354814500	310978000	380668500	251839300	282012600	156442400	298010400	243414600	138815700	404280200	218903000	289910000	306203800	504049100	336908300	222389400	322645500	86490310	272720900	366562800	368308700	324143200	266972000	259513600	320077000	272188000	265433700	511861000	450489400	255548700	241409000	360248300	300961700	372277800	439410300	315500100	179722600	6672304	228885200	246435000	240740400	123200300	146590800	264763100	406808900	379375200	150363600	177021400	404766800	423165900	365384100	474718400	187276700	77476320	314156100	114946100	234598600	238188800	387600000	244281400	43911380	198579200	328167000	131455500	247356700	481994200	358916400	208222400	258671700	150550300	336804500	226459500	69445600	197900600	190866600	302969800	103496800	153191200	120458400	283348100	37692850	231065500	316720100	264093800	258495800	170823400	452001200	390463400	501612000	185954300	302588500	228438800	331874300	251668400	169171800	206736200	280110900	252715500	50994450	404445900	181316100
2/3-Phospho-D-glycerate	54700240	30651530	29647880	37551410	26091640	26960650	23116590	27747100	21732560	12293920	40233570	15190410	29746700	32198150	53212980	30989850	15180980	40639700	8435815	18223940	25768170	48885010	31844880	17459150	27710770	32436010	21489130	23416000	59137850	51090050	19686110	23121330	44105500	32843280	39516800	37721370	33095320	11990680	963294	22400410	21762080	26821460	13637100	9308998	20936850	40813560	42320260	17562810	17392250	40750240	38268370	34583440	46209970	13492350	6445272	26425870	7492898	17016160	16703270	37420380	21779230	2458369	20953740	25154950	12624560	24737440	52472020	31702150	16810710	20032170	13057240	29171040	20169880	10192800	15361290	15030940	36677460	9185891	10352420	9975385	28433280	4242380	22250200	32335720	23491870	21771550	16731060	51813250	39529590	54082770	18398510	25855740	21947490	34754060	24622610	12315890	19850750	21843920	25269180	4610926	47117490	17733550
Phosphoenolpyruvate	40503520	26523130	25626460	29552820	20087110	23241730	13034110	21811040	18486220	10056180	31302700	17154380	22503940	24509830	41966750	25689390	16875170	25662460	6796870	22660260	27106450	31146880	24499010	21417780	20918690	25302310	21606650	20559190	39977470	36048980	19982660	17543420	30594300	24077320	28275300	37101310	24010630	13520990	649890	18098140	18789610	18732750	9830443	11040680	21055570	32809210	30906930	11260880	12306440	30325990	33842630	30068730	34929100	14677480	5640052	25284060	8893151	17507050	19717150	34990860	19469490	3259091	15579020	25840890	8854960	18163470	39984280	28232160	15692160	20654600	11539920	26122090	17763270	5537558	16078650	15621000	22664360	8164526	12154380	10671280	24535260	3000005	17790160	25813820	19539610	18463700	13115130	36138560	29538460	41165330	14402650	24269460	18205950	26861770	19533690	12675280	16371300	22060310	19434830	3992628	33535330	14659380
Pyruvate	12086090	9654365	12790090	6628530	15921680	4449282	8010034	2642206	6293978	28870380	11903060	4949528	21598030	11816700	8616907	11901970	12394550	4267842	13925400	16994030	15094580	8222150	7153042	7722624	17801920	13927570	24386400	21736790	9757251	16363730	15774670	12656420	4622818	16629610	12921610	10968380	16837130	19406960	32348170	24339910	11663130	14679740	38312590	12916160	11570660	14325960	12739660	12387850	20441730	5752048	16743570	10336130	10138310	19523070	24191800	13615890	17356410	14659400	6057798	8571727	9854870	24653750	9438185	12009790	15493350	9463148	14909320	9132535	22897580	13532150	21519490	9545696	6070752	4250176	17400880	24272900	5279858	21213300	20178000	27255200	18631680	11726510	19179530	4105095	12458480	20436510	18068140	12220040	15578310	13458320	22007220	18542430	15047820	16269200	8665409	9087664	22621130	16156790	11541200	37038660	10848440	9026031
Lactate	199705400	131564100	114609900	64234660	83329370	86405100	212852200	62935560	162706200	268899600	81901210	31260750	134636800	120705000	99992540	68487020	97793180	87143880	53303610	159371500	64153740	142003800	62343870	50065920	85033730	75237790	159629400	173842500	78353590	256795000	144078500	76236420	67352100	170586400	82042490	100101500	77737340	170606800	415662400	154059400	174005300	188442000	268340100	202519900	90658430	159410400	100377300	212612000	212802700	128870400	113287000	156582100	137994900	223907000	189651000	101028700	186548300	161306900	151751900	80232140	215933400	149262000	177285900	96055940	112650300	102593800	155537900	71500650	175839300	156461400	134917000	72355960	101530900	92484900	82374790	278869400	96719990	207751100	180790700	231564400	229922400	162545400	181598700	101467400	79149060	207411000	154404500	77959900	87840310	113745400	202521000	187092000	126543800	171002300	201691600	145634000	200561200	69849560	189592600	200517100	145808300	169161000
Maltose	48580	86954	84260	73470	21307	90053	225662	95462	62192	50473	84813	20958	68861	20475	99061	48256	45460	81259	21940	28685	31760	81980	88124	17957	11632	57281	40370	78471	50968	707493	45465	121365	70814	186475	56835	27444	32617	16398	95203	78401	21545	215026	42575	25273	70020	73110	37680	136677	85493	168021	82191	81352	420497	65268	70192	108101	49788	21437	303239	40579	129618	11539	49034	38978	251232	480948	184119	95916	26141	97886	103967	37142	124783	119357	45586	52894	83294	26771	36656	88727	40377	190270	29922	80436	37933	103641	38496	57643	84234	112951	43746	76336	38254	93021	38981	181180	50265	189893	42686	39150	120579	17939
Maltotriose	42433	68180	13036	55548	0	97107	93783	38080	47140	12905	18134	3469	28973	8788	46564	30629	0	66730	9276	10286	0	37199	49046	0	0	27597	8388	29758	61229	233755	26442	72992	19692	117789	0	5467	8487	0	28017	56410	9846	83851	20587	22946	13124	55772	9045	62794	60797	59444	60128	50110	136857	15397	22918	11646	1251	0	48935	25193	72182	0	7391	7446	97728	356552	121546	56041	6472	55072	42453	0	32278	36350	11531	35045	60707	8549	0	22231	10659	70569	16968	29122	14269	48426	17718	31298	11427	19608	7962	54390	5662	37424	21038	63312	24683	140134	66381	16967	84503	4539
Mannitol	336953	259794	501323	248661	354219	291371	308477	33681	210548	97997	343203	150503	416571	205577	430086	249662	8492224	157453	278019	312127	148924	544643	536878	215707	311937	494317	456212	141728	498706	300294	179425	542019	83249	417014	866983	74363	268348	156191	475876	211554	268159	756102	885636	61132	236361	718432	372297	572454	268121	273896	350574	697230	74867	577121	625382	3541713	238297	616056	499910	306743	778332	206620	206258	372011	362415	6231182	563431	233953	174896	357694	964668	165030	204162	1456208	310284	68529	56018	1305356	330830	912714	416390	660268	657815	250572	249727	281553	208438	76625	2759139	321081	347930	244409	247494	297447	297310	1312822	163882	411574	439737	555033	2599324	269508
D-Ribose	724120	761714	621905	392362	322303	199933	535545	345358	598969	547517	530662	220922	485260	995024	436426	584637	552519	398563	295342	446011	582740	683008	276017	259073	1008651	322744	876391	416864	1432353	328860	313640	839851	402472	511062	1316457	438125	552592	581005	471649	487601	456891	598040	663288	620696	346211	708509	425555	573908	468758	371889	442963	846380	388815	2431126	462461	2301025	404137	579758	318210	316532	681958	377354	716730	434835	509894	1559633	984536	453651	913943	243146	1308877	675970	285952	685518	413601	440080	533424	569621	390538	804510	576096	824772	591455	340621	375951	587100	497754	414646	898944	545950	469404	1227883	378601	528372	420860	2191354	533925	921149	437094	655832	757559	348614
D-Rhamnose	190762	185140	53416	247985	117225	297831	14956	269138	248143	158756	63361	242207	421169	362812	16983	372003	270221	310352	333349	180941	247470	153184	465776	89190	370822	384684	191692	156585	472712	206940	306041	28791	357673	284018	287785	155030	326662	187625	7059	331362	132649	49904	660737	357756	29218	417704	320433	241202	133199	159105	202366	32774	386910	151659	103595	192195	133914	254599	259276	399592	90197	153676	100393	232469	283660	185720	65507	203329	201066	126550	184430	250779	301906	229933	104752	207420	462580	432479	242277	23205	245241	97695	226938	192141	267273	190565	172376	285376	40421	145594	149909	74123	197637	176475	275182	76070	177699	294298	483269	193462	276430	269205
Citrate	689731	899524	1048442	2889710	2937092	1302604	10006540	4346544	11741450	2726086	1831465	369176	1664516	1641110	2082089	1777775	1544422	5421532	625874	555471	857030	5690300	1795689	573709	540827	2229096	2621620	3156031	5859340	2962338	2348275	2335467	4816130	2393327	2413602	2603933	1606073	1582405	1202989	2468693	1403695	2997085	2243551	2635486	1600225	1891894	1075626	6320814	3520735	7560514	3062542	1321476	2363321	399347	1458525	1298063	2104572	5649124	3600063	1963919	2187302	2544564	9602106	1053141	2670647	1893201	2328942	3279244	2387459	1925786	850133	2740925	2697496	3314758	616281	1645518	2404021	1747015	2879683	702406	2030930	2955611	1521065	9055075	2579928	3347023	1509086	1625211	1018218	1107766	928665	2033563	1883094	2577447	5569692	6225032	1752250	1877299	2923726	1466791	2124271	2652963
2-Oxoglutarate	1988408	29565	29662	224530	618309	23293	504074	878164	48039	630934	1306584	47927	446515	11676	72920	299730	2552666	152676	152953	157285	310065	77521	387878	7139	40065	469204	333228	679011	488135	893173	97197	260554	1183077	206482	151876	11887	157647	191826	34210	87899	41423	259371	116948	47442	1121923	87017	541992	342132	158586	607090	2201846	85768	3636120	10953	120599	343133	196093	82704	1481128	34133	440727	81861	84207	97981	535159	883688	674722	965743	347070	859929	129947	596585	710969	332934	220386	57541	46975	912477	266148	53711	2095504	209712	45436	376638	2639774	2049531	33711	68539	406612	115287	2224020	755598	235753	189639	604710	199211	171873	207366	104100	65209	182936	138014
2-Oxoglutaramate	95458	97092	47556	54846	90820	66099	97173	33962	112538	132023	104549	19670	86657	93939	89363	64799	122463	85655	56963	49763	90350	121449	50849	72389	76383	84156	92550	116103	113845	88400	45489	78662	56613	78130	157464	93164	57694	106920	173282	57411	98089	125648	98706	122305	61872	84326	56846	144997	127502	213030	67183	75112	115349	926208	76731	236773	129192	134584	68476	74712	130253	69705	127093	52185	88451	165531	130721	59415	123717	83148	89128	102078	52934	91916	41310	116285	105599	120292	90921	122275	109793	165496	83483	98493	56049	123687	77608	59329	107426	57858	102958	156601	80635	96701	97625	295613	85439	64719	83426	104756	75541	87395
Succinate	305751	161719	195366	225340	169997	129784	953487	201661	285095	360238	272847	91753	232486	197450	187745	202382	219339	238840	119779	123789	113347	177049	183287	100403	169716	265054	180782	227337	451427	348390	255892	254893	388406	269590	257631	187309	219027	290036	549070	256073	169229	624072	290659	234015	162928	281724	185546	448475	382129	284061	287949	285120	529294	244689	316341	328343	446227	435733	391975	230900	384446	138415	764128	135107	297134	400957	316058	297760	405228	272035	217578	235370	237497	378721	70737	377834	233432	250184	281700	456336	335289	412053	324434	516286	234615	954802	424707	211545	201194	309730	305521	255297	135031	354547	373152	424154	257890	238892	485901	228736	191375	305533
Fumarate	1039014	468365	299919	363467	865114	196515	471779	403932	353647	1027993	582261	163308	708217	334845	603258	616460	415317	317721	323703	457868	398464	561528	444826	176521	230481	716706	894379	600172	868279	1117992	433858	515263	377625	581011	406809	437585	448070	593876	473118	545627	497365	656085	625906	482498	485060	421522	548480	504092	769740	432431	1427060	502595	1546477	291300	461278	663467	566165	689052	783857	380748	928597	417938	461676	739578	691973	961224	972764	734059	687842	563470	566767	495436	493988	380871	464361	503057	276293	614821	662281	401538	494062	467388	537160	651402	417649	806827	556410	556293	534828	333394	343063	801550	442880	368671	799225	334304	435921	544915	570737	535711	588822	560195
Malate	12718390	6253862	4126181	5375623	11110940	2507797	5990354	6164522	4289646	12942280	8251362	1814968	8518223	4047181	7270328	6982146	6333820	4753474	3197884	6057658	5697318	7769632	6522006	2076318	3017090	9745477	11351660	7454012	11082480	14840850	6142840	7188562	5128368	8375624	4478314	4347983	5718764	8184214	6603290	5999846	6120998	6740786	7524290	6084206	5846214	5000910	7286266	6495212	9487106	4791518	18203460	6741116	19608910	3515695	5915682	8684498	8283856	8560731	10181730	5662620	11218090	5702012	4315076	8651161	8579771	12222800	12614340	8103476	8954452	6726484	7343140	6233558	6127798	4368435	5782846	6048882	3126130	8753601	9155337	5112940	6372302	5481047	7028334	7919398	5846500	10737140	5570876	6158528	7981434	4940037	4081368	12021900	5683020	4651406	10614200	3948624	6864696	6200950	7587806	7073198	7906258	7313262
2-Hydroxyglutarate/Citramalate	542205	499967	530637	1096637	890545	160318	936160	745988	377962	673463	929719	104915	687788	498579	580745	857769	1823798	562044	289365	688952	644324	567518	575764	306759	413646	704915	755937	800415	1543811	2054685	369552	793392	814843	783840	538667	705150	504610	976367	499615	868338	367981	661949	981615	531073	895393	643841	599102	613214	842319	537921	1409779	503012	1553110	290982	355591	843578	793784	716923	607438	688004	1956952	790143	516581	539803	847349	903418	2303092	1220743	719608	508971	980602	788352	755949	842947	485641	456400	339935	599219	684944	480492	1144544	754031	663406	1218110	676944	799482	554018	925830	580371	477243	832352	789649	545374	765515	494643	669691	633058	432499	926882	378850	933002	409325
6-Phospho-D-gluconate	1323274	1456244	716269	978310	625339	1900741	1176617	336186	602392	869424	725159	664358	599603	686646	2314508	612041	564273	926438	715852	735611	577001	1472483	522441	922466	843041	816592	607371	564960	1317143	974576	610552	1972042	614897	820792	771835	1105452	682719	681233	1907817	848081	448386	1165902	713364	714836	2024337	945744	789358	811968	457673	567936	965060	1354010	1121261	584719	1131911	1003506	706628	837251	974050	741420	1183980	746293	554663	545655	690407	713520	996760	721934	670849	658281	743756	486537	549376	690693	807875	582711	526956	667177	647967	1649200	702990	893828	667969	830159	639290	625940	796125	495794	1484734	765052	624078	913304	391317	756255	909079	873092	619425	666517	1089635	830145	871257	735958
D-Erythrose 4-phosphate	601629	183442	153404	112786	110477	99836	59666	64974	73455	89714	276555	60622	152739	84806	70482	135889	114870	100148	136989	129360	70826	345215	103550	118280	108207	79921	109393	132702	89938	124140	207352	101787	95383	224266	167232	114776	180025	119894	58370	243336	250196	159220	17555	90528	129759	227222	119290	53617	83465	72745	164180	80456	423287	35741	65103	210951	132884	73157	122655	97805	211796	28953	65115	69758	142389	437588	52825	198117	187913	142121	99638	182991	74885	77801	127148	130428	133559	68204	61523	100692	154371	67834	74713	108787	76078	89276	175101	354906	271211	235593	90283	102109	158583	201237	76837	94913	110688	144717	98655	113632	240125	102786
Sedoheptulose 1-phosphate	208401	188702	138685	141678	102724	100089	120435	70028	155982	184261	210829	212055	137628	143914	209098	163160	179757	141350	180621	205282	154760	106210	185791	195831	169687	183710	187161	183468	127593	123862	228007	129369	202888	109603	161732	160760	170235	289291	177179	135544	166960	97195	143627	201423	216622	191616	171468	124897	163443	209205	167152	217697	135027	211654	206869	205241	175021	226745	127129	168998	248064	238030	199073	116757	180880	125862	144678	98800	205163	184300	207734	141662	202390	171137	171955	174135	163495	143789	180663	213043	168390	103361	161038	176151	136654	171866	314787	177111	129947	145883	136324	179750	144271	180587	132842	157905	202220	162472	192029	212738	186704	146797
alpha-D-Ribose 1-phosphate	6155642	2920028	2025784	2194830	1389495	1907164	368933	657343	265919	1468277	3204949	792710	2072066	1301058	2515609	2084624	1916769	630380	2549687	1625496	966428	4519354	637749	1064874	1611925	1387599	1257562	1764969	2419138	1824560	2509108	1946924	320949	3945630	2781029	1533277	2475468	1156326	1400026	2712766	1263918	2486887	417926	954351	1799242	3603296	1803729	535537	2134054	485003	2344960	1570601	3907794	330522	1394990	3799618	2201608	1545065	2032724	1881279	3108972	596311	307718	1026353	2111248	3923167	830714	3438581	2162329	1837497	1692427	2359272	445063	623767	1371240	1965294	1613861	920244	1142777	1392085	1104470	633720	866286	855777	1209025	1758360	1956223	5250126	3223572	4277226	959527	1385775	1651069	1762312	1089342	1431829	1489572	2315581	742745	1315157	3993129	1363268
5-Phospho-alpha-D-ribose 1-diphosphate	35178	17479	16614	22671	48492	18067	141325	12928	724210	845375	42479	25845	9787	3561	6175	15282	30852	30043	1800	304	5215	9296	18169	37102	13432	12148	53717	65573	23822	1529	16696	44275	11755	37756	10118	2866	15456	1502575	4928202	17494	31453	84629	473309	1981129	68162	8027	22090	1198834	41190	4839	18529	12619	254587	43852	444429	17643	2608433	3236445	86145	28480	1198435	604131	1392727	31917	147075	371414	18851	16725	1041962	68875	74029	45704	167091	384045	22651	1754290	93993	948876	2361579	1232358	16742	608852	11195	513107	22693	218572	753224	9640	13684	13155	206010	36219	12417	195544	1912811	194958	761146	34870	216837	1523922	18370	960748
Ascorbate	79553	65876	199394	112488	192049	42946	204969	84503	164211	124342	108676	52937	89926	209563	146918	87299	123676	132357	92675	142467	202037	96119	121047	97733	337008	144430	440734	43030	147658	13155	76415	324696	166783	69742	90989	87330	126158	102864	151494	87903	117384	280802	114321	158157	115340	52258	78959	144791	184982	208888	128331	373824	100485	22500	225895	203599	102700	257945	142340	118046	311780	133191	129774	106360	77150	134249	183134	79082	36200	66503	206951	122677	136398	186298	44604	118341	128512	85033	539413	448696	188221	496202	88074	347610	487048	351978	149064	129006	312114	239693	216896	70895	87305	159717	49583	276366	92531	178545	204174	276730	48300	43738
Dehydroascorbate	43692	15905	47511	86490	100521	29911	375077	167522	395539	135296	63740	32108	15771	61906	84211	58086	66852	249412	11504	16809	23881	176537	79606	25626	264521	107513	96340	79430	270276	91413	83554	69785	173228	99112	69909	45876	39145	79896	50843	45585	64195	139981	84693	110010	61890	64210	19840	332891	108952	291806	174165	74404	117285	60334	65026	64059	109933	256635	167810	31774	109699	131226	394140	24565	118451	127790	100883	118073	66475	78492	71796	110210	119509	199900	11931	59883	78587	48599	148691	96575	71785	203015	24374	483022	95167	126852	58431	16033	54810	11238	31862	57761	43574	54747	252662	298746	63469	77706	101160	62134	54973	109319
N-Acetylneuraminate	712495	226512	105238	195917	113729	149231	586615	279722	302678	268060	225446	77239	187263	123976	261158	128176	245955	233155	132030	165924	114552	274606	208223	70187	81041	166456	195617	190368	170733	675853	165135	237037	225434	283672	97063	93297	119756	163194	285028	111713	128466	609014	177665	197935	196935	148443	180482	338273	178691	181046	378062	215514	490736	286699	194750	198045	202161	267387	296292	261984	216243	147097	301629	180067	210554	352247	420261	145522	192454	198186	433389	237196	177448	262781	95859	192805	196487	147238	275908	272967	140746	290697	142294	328968	154733	242267	181281	112808	283562	273049	142340	233315	242978	328938	229871	473496	177256	125244	238204	616631	170819	153560
alpha-D-Glucosamine 1-phosphate	62448	43146	17175	25842	20490	0	47131	94333	11770	33683	0	11824	5359	62106	37144	69811	0	40754	23831	11829	10821	0	7486	11849	2252	59262	82324	15137	79986	18585	35061	16182	54442	40233	75142	0	38607	25261	5505	0	24646	76934	23365	24756	35310	71548	50521	88299	77760	71267	29804	27132	11565	157186	12354	111242	6172	156135	34763	56457	100870	8199	34679	93524	27719	206227	115782	58782	64239	0	90410	5000	48542	9719	9329	16773	10454	121190	63606	46574	22160	29728	7306	13301	58886	27532	0	11479	29961	28606	0	34696	9509	15969	12329	56996	12869	80393	40334	27471	14702	45391
L-Arabinose	724120	761714	621905	392362	322303	199933	535545	345358	598969	547517	530662	220922	485260	995024	436426	584637	552519	398563	295342	446011	582740	683008	276017	259073	1008651	322744	876391	416864	1432353	328860	313640	839851	402472	511062	1316457	438125	552592	581005	471649	487601	456891	598040	663288	620696	346211	708509	425555	573908	468758	371889	442963	846380	388815	2431126	462461	2301025	404137	579758	318210	316532	681958	377354	716730	434835	509894	1559633	984536	453651	913943	243146	1308877	675970	285952	685518	413601	440080	533424	569621	390538	804510	576096	824772	591455	340621	375951	587100	497754	414646	898944	545950	469404	1227883	378601	528372	420860	2191354	533925	921149	437094	655832	757559	348614
1-4-beta-D-Xylan	158199	138369	720469	300368	397906	156642	630444	218085	276734	343974	244438	174338	272843	492974	470556	295041	326225	338258	265887	348757	250704	179208	335032	271950	399006	398622	249766	92103	300382	36658	220489	1051759	477447	414278	305458	206586	388444	186775	346947	273272	305705	638247	38987	208857	369773	245375	312184	426907	354933	457331	362491	1234665	190874	29810	595990	460502	39997	101663	452409	299244	789351	131645	231593	289579	222856	272524	313149	355654	64421	142118	533615	227036	320016	406547	248302	81969	271796	57429	450634	1150554	364109	1022713	224738	142154	427944	177021	193515	310916	796223	674940	497305	179474	211030	309092	121682	415752	218274	486731	520172	720075	285625	95208
trans-4-Hydroxy-L-proline	477821	544651	218789	265970	562535	116032	635918	199681	203936	261129	381516	82179	232373	175435	241142	136366	224152	376673	283803	198505	387866	446742	164829	283894	338940	305927	298308	177824	675075	351166	202602	163841	283604	1185148	658387	212806	316754	183349	166265	322682	170761	458669	386858	322901	248805	1267315	250038	387502	212163	425329	258714	212712	577014	659584	260334	459675	289564	271701	457131	400849	361667	167153	730675	293019	354185	486524	872402	191788	232770	188895	418058	412935	298866	359488	223582	171166	151772	298701	175081	278123	201445	391262	182707	352646	127769	329154	267887	240583	360488	357421	218867	230414	192563	368286	273802	693066	131407	186395	244929	278425	512790	339031
Pantothenate	417915	743871	76135	147521	43801	17026	29191	3815	29269	64989	296687	22011	125029	124678	74649	91115	486627	105019	105677	52883	29230	565841	529203	35251	60028	157742	181371	43358	50314	2428	68536	28009	119121	22865	19590	17586	71689	64635	14297	10390	48532	38052	99724	140229	60160	91047	144526	8321	109506	12303	158097	178216	175200	21368	27795	360875	1528	117259	0	94883	31893	52304	61370	69356	39744	247311	43618	52209	62028	61810	385631	17454	58105	55287	8429	6266	30681	451820	104962	102844	63427	94344	7461	35415	56258	77240	73445	59517	301133	62506	231518	148310	52033	33649	174075	18206	79618	67445	52707	43183	402074	68792
Taurine	9833915	10459160	1472804	12441500	3119652	8733157	38871080	24913820	8911807	6708874	15153880	1608609	3189537	3646523	7372038	3280457	2676796	19852240	3965421	1180852	1353273	4890728	10612280	1170010	1257912	7987770	2983461	6122900	6910502	28575770	5206608	8787275	9542943	11277350	2222272	1644220	3339798	1991007	5175764	5662792	2218128	24356630	4054607	2456348	3561657	2049310	2436402	15005800	5356232	23590540	6442814	3630298	27003070	6441972	5553572	1350513	5798148	1844852	40831750	4014012	9875208	1954863	6795394	1939356	13464510	45025920	15378850	6951956	2751320	6127172	11108450	2951792	10010690	16651780	1873141	3466893	8838852	2643644	2511794	5138402	3074371	9694080	3340638	17335770	2564586	7808780	2590809	5914804	3417727	13719040	4400371	4545724	2377253	12579750	4886111	14439280	3317014	9218980	4027988	2775611	5119888	2188395
(R)-S-Lactoylglutathione	1464705	472851	1832480	1043150	1999636	423510	203842	57688	0	741067	1157594	380472	2596000	599842	378398	1767872	1298355	191450	879994	695841	529083	1332559	636252	137088	1016381	1447884	1395185	1230596	1908503	78594	1839477	1410409	362956	2773494	2841211	913415	1825750	352608	67636	2997256	959191	3501867	62634	379116	598995	2848684	1927374	388091	914191	15998	1542783	474476	2590943	27552	819257	1461934	380268	217793	203257	760372	592230	171615	10450	554435	1202740	2813977	65897	1506560	972295	670921	492755	756491	163993	212770	1659228	1119917	447045	534300	425578	920753	871650	137294	379248	80718	1074806	794077	1111429	2189685	1225242	2092807	1210322	1484032	2164252	787014	337999	166523	904407	2276196	95899	1296133	1809165	642532
Glycerol 3-phosphate	955289	420600	330969	284269	1406680	194977	441919	126484	111355	854004	699250	145871	422964	272561	343379	418446	399246	224788	255129	1130989	701415	1252400	305697	226465	292017	554041	1488325	391548	890350	462151	466871	394437	356347	607798	304326	302254	954317	370005	560231	382989	266507	471257	930119	550058	159805	800864	492012	510277	1219188	208554	877279	274548	652495	1309931	959742	1497346	521679	737166	303755	701437	1442629	1260681	485265	2206802	566066	1141856	333729	2537231	1046568	600430	772130	281620	245321	208582	811293	2409089	127662	1157152	1426620	443131	447754	211526	396914	262251	663073	939982	394485	492328	2010115	499649	282357	534137	562268	207386	389606	307133	830917	422509	255549	735975	917834	1065656
Ethanolamine phosphate	299614	282371	24434	290171	90432	140371	977543	639163	329891	119012	227174	7716	86850	42579	158463	109737	47373	434989	53204	38212	17668	122731	124847	41294	27775	57638	71759	172545	269680	827361	146379	205527	232312	283590	19238	59417	59789	107240	76047	155471	60470	509525	226438	48845	83255	58818	59514	340297	67959	492717	165823	75547	618287	157609	111956	50877	205376	23564	530736	129973	211508	18214	203013	56728	175490	727432	353302	44731	86428	103309	225933	231570	293089	862054	11509	95664	390183	85957	48573	65439	78944	138238	48458	872167	36380	267055	61474	160907	89895	349268	57268	101272	60937	387294	149728	297675	87385	233834	100579	62522	144383	42337
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	KEGGID	parent	medRt
ATP	C00002	505.9886	0.58
ADP	C00008	426.0226	0.58
AMP	C00020	346.0551	0.63
dAMP	C00360	330.0596	0.64
GDP	C00035	442.0158	0.56
Cytidine	C00475	242.0783	0.64
UDP	C00015	402.9997	0.86
UMP	C00105	323.0283	0.59
Uracil	C00106	111.0185	0.62
IDP	C00104	427.0074	0.55
IMP	C00130	347.0393	0.61
Inosine	C00294	267.0724	0.60
5-6-Dihydrothymine	C00906	127.0499	0.65
4-Pyridoxate	C00847	182.0449	0.89
UDP-glucose	C00029	565.0470	0.54
Phosphate	C00009	96.9680	0.59
Diphosphate	C00013	176.9350	0.58
D-Glucose	C00031	179.0550	0.65
Hexose phosphate	C02965	259.0221	0.56
D-Fructose 1-6-bisphosphate	C00354	338.9883	0.54
D-Glyceraldehyde 3-phosphate/Glycerone phosphate	C00118	168.9896	0.57
1-3-Bisphosphoglycerate	C00236	264.9516	0.55
2/3-Phospho-D-glycerate	C00631	184.9845	0.55
Phosphoenolpyruvate	C00074	166.9741	0.55
Pyruvate	C00022	87.0071	0.63
Lactate	C01432	89.0227	0.62
Maltose	C00208	341.1091	0.65
Maltotriose	C01835	503.1611	0.65
Mannitol	C00392	181.0704	0.67
D-Ribose	C00121	149.0447	0.62
D-Rhamnose	C01684	163.0603	0.67
Citrate	C00158	191.0190	0.56
2-Oxoglutarate	C00026	145.0130	0.56
2-Oxoglutaramate	C00940	144.0291	0.62
Succinate	C00042	117.0178	0.57
Fumarate	C00122	115.0021	0.56
Malate	C00149	133.0129	0.56
2-Hydroxyglutarate/Citramalate	C02630	147.0287	0.57
6-Phospho-D-gluconate	C00345	275.0173	0.54
D-Erythrose 4-phosphate	C00279	199.0002	0.55
Sedoheptulose 1-phosphate	C06222	289.0377	1.71
alpha-D-Ribose 1-phosphate	C00620	229.0116	0.57
5-Phospho-alpha-D-ribose 1-diphosphate	C00119	388.9447	0.56
Ascorbate	C00072	175.0238	0.64
Dehydroascorbate	C05422	173.0079	0.57
N-Acetylneuraminate	C00270	308.0980	0.61
alpha-D-Glucosamine 1-phosphate	C06156	258.0384	0.61
L-Arabinose	C00259	149.0443	0.62
1-4-beta-D-Xylan	C02352	131.0336	0.66
trans-4-Hydroxy-L-proline	C01157	130.0497	0.65
Pantothenate	C00864	218.1031	0.66
Taurine	C00245	124.0059	0.64
(R)-S-Lactoylglutathione	C03451	378.0977	0.64
Glycerol 3-phosphate	C00093	171.0057	0.58
Ethanolamine phosphate	C00346	140.0105	0.61
METABOLITES_END
#END