#METABOLOMICS WORKBENCH Naviaux_lab_20210421_122658 DATATRACK_ID:2581 STUDY_ID:ST001789 ANALYSIS_ID:AN002902 PROJECT_ID:000000 VERSION 1 CREATED_ON May 15, 2021, 8:33 am #PROJECT PR:PROJECT_SUMMARY Metabolomics has emerged as a powerful new tool in precision medicine for PR:PROJECT_SUMMARY gaining mechanistic insight into health and disease. The objective of this PR:PROJECT_SUMMARY project was to investigate the acute metabolomic changes in plasma and PR:PROJECT_SUMMARY cerebrospinal fluid in response to endurance exercise. Young adult volunteers PR:PROJECT_SUMMARY were enrolled, and the participants completed a monitored outdoor 90-minute run. PR:PROJECT_SUMMARY Cerebrospinal fluid (CSF) was collected at rest (Pre) and 60 minutes (Time 60) PR:PROJECT_SUMMARY after the run. Plasma samples were collected at rest, immediately after the run PR:PROJECT_SUMMARY (Time 0) and 60 minutes after the run (Time 60). Broad-spectrum targeted PR:PROJECT_SUMMARY metabolomics was conducted using liquid chromatography coupled with tandem mass PR:PROJECT_SUMMARY spectrometry (LC-MS/MS). This study provided insights into the benefits of PR:PROJECT_SUMMARY mental health and neuroprotective benefits of endurance exercise. PR:INSTITUTE University of California, San Diego PR:DEPARTMENT Department of Medicine PR:LABORATORY The Naviaux Lab PR:FIRST_NAME Robert PR:ADDRESS 214 Dickinson St., Room C-107 PR:EMAIL rnaviaux@health.ucsd.edu PR:PHONE 619-543-2904 PR:FUNDING_SOURCE UCSD Christini Fund and the Lennox Foundation PR:PROJECT_TITLE Acute metabolomic changes of plasma and cerebrospinal fluid in response to PR:PROJECT_TITLE endurance exercise PR:LAST_NAME Naviaux #STUDY ST:STUDY_TITLE Acute metabolomic changes of plasma in response to endurance exercise ST:STUDY_SUMMARY This study compared the metabolomic differences in plasma of young adult ST:STUDY_SUMMARY volunteers between before (Pre), immediately after the run (Time 0) and 60 ST:STUDY_SUMMARY minutes after the 90-min run (Time 60). ST:INSTITUTE University of California, San Diego ST:DEPARTMENT Department of Medicine ST:LABORATORY The Naviaux Lab ST:LAST_NAME Naviaux ST:FIRST_NAME Robert ST:ADDRESS 214 Dickinson St., Room C-107 ST:EMAIL rnaviaux@health.ucsd.edu ST:NUM_GROUPS 3 ST:TOTAL_SUBJECTS 19 ST:NUM_MALES 13 ST:NUM_FEMALES 6 ST:PHONE 619-543-2904 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:AGE_OR_AGE_RANGE 25(IQR 22-31) SU:GENDER Male and female SU:HUMAN_NUTRITION Participants were given a banana (~100g) #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS LP11 LP11_plasma_B_F Group:Pre SUBJECT_SAMPLE_FACTORS LP15 LP15_plasma_B_F Group:Pre SUBJECT_SAMPLE_FACTORS LP19 LP19_plasma_B_F Group:Pre SUBJECT_SAMPLE_FACTORS LP20 LP20_plasma_B_F Group:Pre SUBJECT_SAMPLE_FACTORS LP23 LP23_plasma_B_F Group:Pre SUBJECT_SAMPLE_FACTORS LP30 LP30_plasma_B_F Group:Pre SUBJECT_SAMPLE_FACTORS LP14 LP14_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP16 LP16_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP18 LP18_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP21 LP21_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP22 LP22_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP24 LP24_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP25 LP25_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP26 LP26_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP27 LP27_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP28 LP28_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP29 LP29_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP31 LP31_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP32 LP32_plasma_B_M Group:Pre SUBJECT_SAMPLE_FACTORS LP11 LP11_plasma_R2_F Group:Time 0 SUBJECT_SAMPLE_FACTORS LP15 LP15_plasma_R2_F Group:Time 0 SUBJECT_SAMPLE_FACTORS LP19 LP19_plasma_R2_F Group:Time 0 SUBJECT_SAMPLE_FACTORS LP20 LP20_plasma_R2_F Group:Time 0 SUBJECT_SAMPLE_FACTORS LP23 LP23_plasma_R2_F Group:Time 0 SUBJECT_SAMPLE_FACTORS LP30 LP30_plasma_R2_F Group:Time 0 SUBJECT_SAMPLE_FACTORS LP14 LP14_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP16 LP16_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP18 LP18_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP21 LP21_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP22 LP22_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP24 LP24_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP25 LP25_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP26 LP26_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP27 LP27_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP28 LP28_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP29 LP29_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP31 LP31_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP32 LP32_plasma_R2_M Group:Time 0 SUBJECT_SAMPLE_FACTORS LP11 LP11_plasma_R3_F Group:Time 60 SUBJECT_SAMPLE_FACTORS LP15 LP15_plasma_R3_F Group:Time 60 SUBJECT_SAMPLE_FACTORS LP19 LP19_plasma_R3_F Group:Time 60 SUBJECT_SAMPLE_FACTORS LP20 LP20_plasma_R3_F Group:Time 60 SUBJECT_SAMPLE_FACTORS LP23 LP23_plasma_R3_F Group:Time 60 SUBJECT_SAMPLE_FACTORS LP30 LP30_plasma_R3_F Group:Time 60 SUBJECT_SAMPLE_FACTORS LP14 LP14_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP16 LP16_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP18 LP18_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP21 LP21_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP22 LP22_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP24 LP24_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP25 LP25_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP26 LP26_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP27 LP27_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP28 LP28_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP29 LP29_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP31 LP31_plasma_R3_M Group:Time 60 SUBJECT_SAMPLE_FACTORS LP32 LP32_plasma_R3_M Group:Time 60 #COLLECTION CO:COLLECTION_SUMMARY Measurements and samples were collected on two days separated by 4 weeks. CO:COLLECTION_SUMMARY Samples were drawn at the same time on the two experimental days to control for CO:COLLECTION_SUMMARY circadian rhythms. A baseline blood sample (Pre) was collected, the cannula was CO:COLLECTION_SUMMARY closed with a screw cap and protected with an elastic bandage. Participants were CO:COLLECTION_SUMMARY given a banana (~100g) then completed a 90-minute outdoor run at local time CO:COLLECTION_SUMMARY 09:00 to 10:30 am. . Immediately after completing the 90-minute run, a time 0 CO:COLLECTION_SUMMARY blood sample was collected (Time 0). After 60 minutes of recovery (1130 am local CO:COLLECTION_SUMMARY time), a time 60 blood sample was collected (Time 60). CO:SAMPLE_TYPE Blood (plasma) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Participants were given a banana (~100g) then completed a 90-minute outdoor run TR:TREATMENT_SUMMARY at local time 09:00 to 10:30 am, maintaining an effort of 75%-80% of their heart TR:TREATMENT_SUMMARY rate. A baseline blood sample (Pre) was collected before the run. Immediately TR:TREATMENT_SUMMARY after completing the 90-minute run, a time 0 blood sample was collected (Time TR:TREATMENT_SUMMARY 0). After 60 minutes of recovery (1130 am local time), a time 60 blood sample TR:TREATMENT_SUMMARY was collected (Time 60). #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Plasma samples (90 µl) were mixed with 5 µl of commercial internal standards SP:SAMPLEPREP_SUMMARY and 5 µl of custom-synthesized 13C labeled standards and then incubated for 10 SP:SAMPLEPREP_SUMMARY min at room temperature to permit small molecules and vitamins in the internal SP:SAMPLEPREP_SUMMARY standards to associate with plasma binding proteins. The metabolites were SP:SAMPLEPREP_SUMMARY extracted with 400 µl of cold (-20 °C) methanol: acetonitrile (50:50, v/v), SP:SAMPLEPREP_SUMMARY yielding a final concentration of methanol: acetonitrile: water (40:40:20, SP:SAMPLEPREP_SUMMARY v/v/v). The samples were then vortexed vigorously, incubated on crushed ice for SP:SAMPLEPREP_SUMMARY 10 min, and then centrifuged at 16,000 g for 10 min at 4 °C. The supernatants SP:SAMPLEPREP_SUMMARY containing the extracted metabolites and internal standards were transferred to SP:SAMPLEPREP_SUMMARY labeled cryotubes and stored at -80 °C prior to LC-MS/MS. SP:PROCESSING_STORAGE_CONDITIONS On ice SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Ten µL of the extract was injected into the column through a CTC PAL CH:CHROMATOGRAPHY_SUMMARY autosampler. The samples were separated in the RP model using a Raptor Biphenyl CH:CHROMATOGRAPHY_SUMMARY column (150 × 2.1 mm, 2.7 µm) (Restek, PA). The LC conditions were as follows: CH:CHROMATOGRAPHY_SUMMARY Mobile phase A: 90% H2O with 0.1% formic acid and 10% MEOH, pH 4.0. Mobile phase CH:CHROMATOGRAPHY_SUMMARY B: MEOH-IPA (50:50, v/v) with 0.1% formic acid. The gradient was: 0 - 2 min 10% CH:CHROMATOGRAPHY_SUMMARY B, 2.1 - 4 min 40% B, 4 -12 min, linear ramping up to 100% B, 12 – 18 min 100% CH:CHROMATOGRAPHY_SUMMARY B, 19 - 24 min 10% B, 24.1 min stop. The flow rate was 250 µL/min, and the CH:CHROMATOGRAPHY_SUMMARY column temperature was controlled at 40 ºC. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Shimadzu 20AD CH:COLUMN_NAME Raptor Biphenyl column (150 × 2.1 mm, 2.7 µm) CH:FLOW_GRADIENT Constant CH:FLOW_RATE 250 µL/min CH:COLUMN_TEMPERATURE 40 CH:SOLVENT_A 90% H2O with 0.1% formic acid and 10% MEOH, pH 4.0 CH:SOLVENT_B MEOH-IPA (50:50, v/v) with 0.1% formic acid CH:COLUMN_PRESSURE 2800 psi - 4200 psi CH:INJECTION_TEMPERATURE 4 CH:OVEN_TEMPERATURE 40 CH:SAMPLE_LOOP_SIZE 10 CH:SAMPLE_SYRINGE_SIZE 100 #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME The Naviaux Lab AN:SOFTWARE_VERSION Analyst 1.6.2 AN:DATA_FORMAT .wiff #MS MS:INSTRUMENT_NAME ABI Sciex 5500 QTrap MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE UNSPECIFIED MS:MS_COMMENTS The MS/MS detection was performed using electrospray ionization (ESI) and MS:MS_COMMENTS advanced scheduled multiple reaction monitoring (MRM) with dynamic windowing and MS:MS_COMMENTS fast polarity switch. The ESI source conditions were set as follows: MS:MS_COMMENTS electrospray voltage of -4500 V for negative mode and 5500 V for positive mode, MS:MS_COMMENTS source temperature of 500 °C, curtain gas of 30, ion source gas 1, and gas 2 of MS:MS_COMMENTS 35 psi, respectively.Peaks were manually inspected and integrated using MS:MS_COMMENTS Multiquant 3.0.2. The peak area was exported to excel for further analysis. MS:COLLISION_ENERGY Compound-dependent MS:ION_SOURCE_TEMPERATURE 500 MS:ION_SPRAY_VOLTAGE -4500 V for negative and 5500 V for positive MS:IONIZATION ESI MS:MASS_ACCURACY 0.1 Da #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS peak area MS_METABOLITE_DATA_START Samples LP11_plasma_B_F LP15_plasma_B_F LP19_plasma_B_F LP20_plasma_B_F LP23_plasma_B_F LP30_plasma_B_F LP14_plasma_B_M LP16_plasma_B_M LP18_plasma_B_M LP21_plasma_B_M LP22_plasma_B_M LP24_plasma_B_M LP25_plasma_B_M LP26_plasma_B_M LP27_plasma_B_M LP28_plasma_B_M LP29_plasma_B_M LP31_plasma_B_M LP32_plasma_B_M LP11_plasma_R2_F LP15_plasma_R2_F LP19_plasma_R2_F LP20_plasma_R2_F LP23_plasma_R2_F LP30_plasma_R2_F LP14_plasma_R2_M LP16_plasma_R2_M LP18_plasma_R2_M LP21_plasma_R2_M LP22_plasma_R2_M LP24_plasma_R2_M LP25_plasma_R2_M LP26_plasma_R2_M LP27_plasma_R2_M LP28_plasma_R2_M LP29_plasma_R2_M LP31_plasma_R2_M LP32_plasma_R2_M LP11_plasma_R3_F LP15_plasma_R3_F LP19_plasma_R3_F LP20_plasma_R3_F LP23_plasma_R3_F LP30_plasma_R3_F LP14_plasma_R3_M LP16_plasma_R3_M LP18_plasma_R3_M LP21_plasma_R3_M LP22_plasma_R3_M LP24_plasma_R3_M LP25_plasma_R3_M LP26_plasma_R3_M LP27_plasma_R3_M LP28_plasma_R3_M LP29_plasma_R3_M LP31_plasma_R3_M LP32_plasma_R3_M Factors Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Pre Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 0 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 Group:Time 60 DeoxyCer(m18:1/16:0) 1.39E+05 8.54E+04 6.14E+04 1.53E+05 2.04E+05 1.67E+05 1.17E+05 1.41E+05 9.16E+04 2.01E+05 1.49E+05 1.42E+05 2.11E+05 1.58E+05 1.93E+05 1.78E+05 1.96E+05 1.86E+05 2.22E+05 1.94E+05 1.29E+05 7.55E+04 1.71E+05 2.63E+05 1.74E+05 1.47E+05 1.60E+05 1.23E+05 1.85E+05 1.63E+05 1.54E+05 2.38E+05 1.86E+05 2.67E+05 1.53E+05 1.91E+05 2.40E+05 2.53E+05 1.81E+05 9.31E+04 6.34E+04 1.88E+05 2.14E+05 2.10E+05 9.47E+04 1.21E+05 1.50E+05 2.03E+05 1.34E+05 1.30E+05 3.08E+05 1.67E+05 2.15E+05 1.75E+05 1.77E+05 2.10E+05 1.77E+05 DeoxyCer(m18:1/18:0) 7.28E+04 1.07E+05 6.53E+04 1.49E+05 1.27E+05 1.48E+05 2.21E+05 2.54E+05 1.69E+05 9.51E+04 1.44E+05 1.81E+05 1.78E+05 1.05E+05 1.89E+05 7.30E+04 8.94E+04 1.31E+05 1.75E+05 1.06E+05 1.44E+05 9.84E+04 1.64E+05 1.27E+05 1.14E+05 2.16E+05 2.19E+05 1.21E+05 9.86E+04 1.50E+05 1.20E+05 2.16E+05 1.35E+05 2.68E+05 1.12E+05 1.04E+05 1.53E+05 1.10E+05 7.08E+04 1.38E+05 7.72E+04 2.43E+05 1.27E+05 1.68E+05 1.90E+05 2.70E+05 1.24E+05 9.21E+04 1.38E+05 5.64E+04 2.00E+05 1.41E+05 2.73E+05 1.01E+05 1.16E+05 1.16E+05 1.27E+05 DeoxyCer(m18:1/20:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DeoxyCer(m18:1/22:0) 1.21E+05 1.01E+05 2.45E+04 1.12E+05 9.07E+04 1.12E+05 1.55E+05 9.02E+04 7.25E+04 6.13E+04 1.10E+05 7.01E+04 1.14E+05 7.39E+04 1.47E+05 8.65E+04 6.55E+04 5.78E+04 9.95E+04 1.47E+05 1.18E+05 3.26E+04 1.08E+05 1.16E+05 9.03E+04 1.24E+05 1.02E+05 1.07E+05 8.52E+04 1.11E+05 4.65E+04 1.23E+05 6.02E+04 1.26E+05 1.07E+05 7.59E+04 7.78E+04 1.34E+05 1.59E+05 8.73E+04 4.13E+04 1.28E+05 8.51E+04 1.46E+05 8.86E+04 1.29E+05 9.15E+04 7.31E+04 1.36E+05 6.42E+04 9.29E+04 8.98E+04 1.48E+05 1.02E+05 5.50E+04 7.92E+04 9.18E+04 DeoxyCer(m18:1/24:0) 1.26E+05 1.17E+05 2.79E+04 9.89E+04 9.97E+04 1.14E+05 1.51E+05 6.25E+04 8.23E+04 7.22E+04 1.22E+05 5.27E+04 1.13E+05 9.92E+04 1.31E+05 1.15E+05 1.09E+05 7.96E+04 1.32E+05 1.73E+05 7.33E+04 2.78E+04 1.01E+05 1.05E+05 9.61E+04 1.34E+05 1.09E+05 7.21E+04 7.23E+04 1.26E+05 5.51E+04 9.03E+04 9.16E+04 1.19E+05 1.06E+05 1.08E+05 8.32E+04 1.29E+05 1.53E+05 8.02E+04 4.62E+04 8.89E+04 9.48E+04 1.15E+05 9.40E+04 9.98E+04 8.68E+04 8.32E+04 1.11E+05 5.69E+04 1.07E+05 7.53E+04 1.33E+05 1.23E+05 9.90E+04 9.26E+04 1.13E+05 DeoxyCer(m18:1/24:1) 8.97E+04 1.51E+05 4.31E+04 1.14E+05 1.45E+05 1.28E+05 2.17E+05 1.21E+05 1.19E+05 1.00E+05 1.73E+05 7.30E+04 1.39E+05 1.47E+05 2.17E+05 1.17E+05 1.04E+05 1.23E+05 1.36E+05 1.21E+05 1.06E+05 7.38E+04 1.46E+05 1.84E+05 1.19E+05 2.34E+05 7.75E+04 1.46E+05 1.08E+05 1.91E+05 7.71E+04 1.63E+05 1.47E+05 2.30E+05 1.20E+05 9.64E+04 1.02E+05 1.12E+05 1.05E+05 1.15E+05 6.35E+04 1.34E+05 1.78E+05 1.13E+05 1.67E+05 7.64E+04 1.59E+05 1.17E+05 1.68E+05 9.03E+04 1.76E+05 1.60E+05 2.27E+05 1.50E+05 8.49E+04 1.19E+05 1.26E+05 DeoxyCer(m18:1/26:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DeoxyCer(m18:1/26:1) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DeoxydihydroCer(m18:0/16:0) 6.07E+04 3.74E+04 2.44E+04 4.11E+04 6.39E+04 7.57E+04 7.94E+04 5.96E+04 3.75E+04 4.30E+04 4.91E+04 3.36E+04 5.27E+04 4.75E+04 1.08E+05 5.59E+04 8.97E+04 6.82E+04 7.42E+04 7.52E+04 5.47E+04 1.53E+04 5.01E+04 7.43E+04 6.95E+04 5.26E+04 6.64E+04 3.84E+04 4.87E+04 7.59E+04 3.64E+04 5.07E+04 5.48E+04 1.16E+05 6.40E+04 9.22E+04 5.82E+04 7.96E+04 5.89E+04 3.69E+04 1.56E+04 4.29E+04 6.03E+04 7.69E+04 4.70E+04 4.08E+04 4.44E+04 5.27E+04 7.21E+04 2.05E+04 7.39E+04 4.75E+04 9.90E+04 6.40E+04 7.17E+04 6.26E+04 7.55E+04 DeoxydihydroCer(m18:0/18:0) 2.28E+04 3.50E+03 2.70E+03 1.57E+04 2.36E+04 1.86E+04 2.26E+04 2.88E+04 2.20E+04 3.46E+04 4.33E+04 6.57E+03 2.69E+04 4.17E+04 3.51E+04 3.82E+04 1.81E+04 1.61E+04 3.14E+04 1.51E+04 1.25E+04 5.07E+04 1.40E+04 4.34E+04 3.08E+04 2.48E+04 2.93E+04 1.92E+04 2.62E+04 2.80E+04 8.31E+03 1.90E+04 4.10E+04 2.67E+04 2.70E+04 4.96E+04 1.61E+04 3.08E+04 1.37E+04 4.27E+03 1.10E+04 2.88E+04 2.29E+04 3.02E+04 2.00E+04 2.04E+04 9.47E+03 1.06E+04 3.88E+04 7.46E+03 3.04E+04 4.78E+04 4.49E+04 2.27E+04 5.75E+04 1.20E+04 2.65E+04 DeoxydihydroCer(m18:0/20:0) 5.05E+03 4.72E+03 2.38E+03 5.23E+03 7.46E+03 7.51E+03 1.43E+04 4.27E+03 3.69E+03 1.06E+04 1.03E+04 8.23E+03 9.83E+03 5.05E+03 7.25E+03 5.15E+03 1.12E+04 1.24E+04 6.36E+03 8.21E+03 5.64E+03 1.39E+03 7.31E+03 7.47E+03 8.26E+03 9.20E+03 2.61E+03 5.80E+03 8.25E+03 6.36E+03 8.56E+03 5.08E+03 6.61E+03 5.51E+03 1.28E+04 7.07E+03 8.25E+03 1.01E+04 4.40E+03 5.63E+03 4.65E+03 1.24E+04 8.44E+03 1.00E+04 8.71E+03 1.99E+03 5.56E+03 7.41E+03 9.85E+03 8.38E+03 6.76E+03 7.29E+03 7.57E+03 8.00E+03 6.28E+03 7.49E+03 1.14E+04 DeoxydihydroCer(m18:0/22:0) 3.47E+04 2.67E+04 2.90E+04 4.04E+04 7.02E+04 5.51E+04 5.98E+04 3.47E+04 2.77E+04 6.96E+04 5.24E+04 7.25E+04 5.51E+04 5.03E+04 4.70E+04 4.48E+04 4.46E+04 4.82E+04 6.17E+04 5.05E+04 3.17E+04 2.45E+04 4.96E+04 3.04E+04 4.29E+04 7.07E+04 3.81E+04 2.92E+04 5.87E+04 5.24E+04 5.88E+04 3.50E+04 5.98E+04 3.49E+04 4.26E+04 5.61E+04 6.23E+04 4.16E+04 3.65E+04 2.17E+04 3.51E+04 5.89E+04 3.28E+04 4.45E+04 5.06E+04 3.67E+04 4.37E+04 5.38E+04 3.81E+04 5.49E+04 4.26E+04 3.85E+04 3.33E+04 5.31E+04 6.45E+04 6.02E+04 5.44E+04 DeoxydihydroCer(m18:0/24:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DeoxydihydroCer(m18:0/24:1) 2.61E+04 2.93E+04 1.52E+04 2.78E+04 3.92E+04 3.54E+04 5.90E+04 3.09E+04 2.84E+04 1.66E+04 5.89E+04 1.80E+04 3.83E+04 3.89E+04 4.35E+04 3.66E+04 3.85E+04 2.58E+04 3.30E+04 3.25E+04 3.12E+04 9.41E+03 3.50E+04 4.15E+04 2.31E+04 6.12E+04 1.80E+04 2.40E+04 2.58E+04 3.43E+04 2.32E+04 3.17E+04 4.14E+04 3.56E+04 4.11E+04 3.61E+04 3.79E+04 3.43E+04 1.73E+04 1.82E+04 1.25E+04 3.48E+04 3.39E+04 3.11E+04 3.22E+04 1.64E+04 3.38E+04 2.05E+04 4.84E+04 2.10E+04 3.88E+04 4.05E+04 5.99E+04 4.44E+04 2.31E+04 3.23E+04 3.37E+04 DeoxydihydroCer(m18:0/26:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DeoxydihydroCer(m18:0/26:1) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/16:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/18:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/18:1) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/19:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/20:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/21:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD2(d18:1/22:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/14:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/15:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/16:0) 5.70E+03 5.64E+03 3.24E+03 1.36E+04 1.18E+04 1.49E+04 5.26E+03 3.94E+03 2.39E+03 9.83E+03 1.23E+04 1.37E+04 1.47E+04 9.01E+03 8.62E+03 8.51E+03 1.01E+04 1.02E+04 7.80E+03 1.04E+04 6.80E+03 4.43E+03 1.76E+04 1.80E+04 1.53E+04 6.34E+03 4.99E+03 3.63E+03 1.13E+04 1.13E+04 1.12E+04 1.67E+04 1.12E+04 1.41E+04 9.51E+03 1.27E+04 1.18E+04 1.34E+04 1.04E+04 5.11E+03 5.26E+03 1.31E+04 1.40E+04 1.60E+04 3.23E+03 3.82E+03 3.88E+03 1.41E+04 1.08E+04 1.42E+04 1.28E+04 9.83E+03 7.73E+03 1.24E+04 1.17E+04 1.24E+04 1.01E+04 GD3(d18:1/16:1) 4.00E+03 3.11E+03 1.94E+03 4.64E+03 5.85E+03 4.93E+03 4.35E+03 2.63E+03 3.47E+03 5.37E+03 3.99E+03 5.46E+03 7.03E+03 4.14E+03 3.85E+03 2.72E+03 5.00E+03 5.06E+03 4.06E+03 6.17E+03 5.20E+03 2.72E+03 8.20E+03 7.41E+03 6.14E+03 4.31E+03 2.82E+03 2.54E+03 4.32E+03 4.75E+03 6.11E+03 7.86E+03 5.35E+03 5.17E+03 4.95E+03 5.17E+03 4.58E+03 3.53E+03 4.91E+03 4.51E+03 3.40E+03 5.62E+03 5.67E+03 5.86E+03 2.51E+03 3.28E+03 3.73E+03 4.75E+03 5.88E+03 6.55E+03 6.59E+03 6.51E+03 4.06E+03 2.36E+03 4.77E+03 6.92E+03 3.59E+03 GD3(d18:1/17:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/18:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/18:1) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/19:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/20:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/21:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/22:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/23:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/24:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GD3(d18:1/25:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GM2(d18:1/16:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GM2(d18:1/16:1) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GM2(d18:1/18:1) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GM2(d18:1/20:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GM3(d18:1/16:0) 6.72E+04 5.93E+04 3.75E+04 1.24E+05 1.37E+05 1.24E+05 7.73E+04 4.43E+04 6.00E+04 8.28E+04 9.49E+04 1.19E+05 1.67E+05 1.05E+05 1.01E+05 7.85E+04 1.51E+05 9.22E+04 7.75E+04 1.20E+05 7.18E+04 8.30E+04 1.39E+05 1.98E+05 1.19E+05 9.76E+04 6.09E+04 7.85E+04 1.19E+05 1.10E+05 1.07E+05 1.66E+05 1.20E+05 1.83E+05 1.43E+05 1.39E+05 1.05E+05 8.82E+04 8.36E+04 6.70E+04 6.46E+04 1.44E+05 1.26E+05 1.61E+05 6.36E+04 8.94E+04 1.07E+05 1.14E+05 6.95E+04 1.66E+05 1.81E+05 1.52E+05 1.29E+05 1.70E+05 1.70E+05 1.72E+05 1.08E+05 GM3(d18:1/16:1) 1.63E+04 1.85E+04 2.10E+04 1.96E+04 3.20E+04 2.25E+04 2.16E+04 1.36E+04 1.40E+04 2.47E+04 2.19E+04 3.81E+04 1.91E+04 1.66E+04 1.73E+04 1.58E+04 1.74E+04 2.92E+04 1.09E+04 2.54E+04 3.02E+04 3.55E+04 2.90E+04 3.96E+04 2.45E+04 2.66E+04 2.17E+04 2.35E+04 1.96E+04 1.81E+04 2.82E+04 3.81E+04 1.87E+04 2.68E+04 2.20E+04 2.52E+04 2.62E+04 1.85E+04 2.23E+04 2.26E+04 2.74E+04 2.22E+04 2.60E+04 2.85E+04 2.17E+04 1.88E+04 3.34E+04 3.18E+04 1.61E+04 3.70E+04 3.59E+04 2.45E+04 2.03E+04 2.25E+04 3.09E+04 4.21E+04 2.64E+04 GM3(d18:1/18:0) 1.81E+04 1.83E+04 1.59E+04 3.76E+04 2.35E+04 2.60E+04 3.27E+04 1.32E+04 1.31E+04 3.89E+04 1.24E+04 3.07E+04 3.47E+04 2.87E+04 3.56E+04 2.59E+04 3.80E+04 3.12E+04 2.22E+04 1.93E+04 1.27E+04 2.82E+04 2.80E+04 3.38E+04 3.80E+04 3.61E+04 1.87E+04 1.03E+04 2.67E+04 2.52E+04 3.73E+04 4.23E+04 3.21E+04 3.36E+04 3.34E+04 5.56E+04 3.25E+04 1.69E+04 1.89E+04 2.20E+04 2.13E+04 3.56E+04 3.24E+04 4.02E+04 2.23E+04 8.18E+03 2.11E+04 2.35E+04 3.63E+04 4.65E+04 4.42E+04 2.47E+04 3.45E+04 2.84E+04 4.48E+04 2.09E+04 1.87E+04 GM3(d18:1/18:1) 1.69E+04 1.95E+04 1.56E+04 2.83E+04 3.37E+04 2.08E+04 2.94E+04 2.13E+04 1.78E+04 2.05E+04 1.48E+04 4.67E+04 2.64E+04 2.05E+04 1.88E+04 1.39E+04 4.43E+04 1.88E+04 2.13E+04 2.10E+04 3.60E+04 2.52E+04 4.01E+04 2.72E+04 2.04E+04 4.95E+04 1.68E+04 3.15E+04 1.46E+04 2.08E+04 3.43E+04 2.70E+04 1.90E+04 4.15E+04 3.52E+04 4.00E+04 4.91E+04 1.48E+04 2.42E+04 2.75E+04 1.57E+04 2.88E+04 2.20E+04 4.28E+04 2.03E+04 2.45E+04 3.23E+04 1.78E+04 1.97E+04 3.87E+04 2.49E+04 2.51E+04 2.58E+04 2.38E+04 6.49E+04 3.82E+04 2.08E+04 GM3(d18:1/20:0) N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GM3(d18:1/22:0) 1.17E+04 1.72E+04 1.23E+04 1.59E+04 1.64E+04 1.15E+04 1.78E+04 6.27E+03 1.64E+04 1.20E+04 9.99E+03 8.30E+03 1.39E+04 9.37E+03 1.85E+04 2.02E+04 2.07E+04 1.59E+04 1.13E+04 3.96E+04 1.02E+04 6.71E+03 7.76E+03 1.39E+04 1.88E+04 1.88E+04 8.35E+03 8.86E+03 1.75E+04 7.89E+03 7.87E+03 1.05E+04 1.73E+04 1.32E+04 5.80E+03 1.96E+04 8.52E+03 1.04E+04 2.37E+04 1.80E+04 8.35E+03 3.01E+04 1.65E+04 1.52E+04 7.33E+03 8.35E+03 1.19E+04 9.04E+03 1.96E+04 1.83E+04 1.20E+04 1.33E+04 1.97E+04 1.26E+04 2.36E+04 1.77E+04 1.43E+04 GM3(d18:1/24:0) 1.35E+04 1.43E+04 1.73E+04 2.55E+04 2.14E+04 1.42E+04 3.04E+04 1.41E+04 1.63E+04 2.54E+04 1.14E+04 1.87E+04 2.26E+04 2.01E+04 3.68E+04 1.30E+04 4.87E+04 2.08E+04 1.44E+04 1.66E+04 1.53E+04 2.03E+04 2.18E+04 2.65E+04 1.15E+04 1.28E+04 1.08E+04 1.63E+04 1.05E+04 1.88E+04 1.73E+04 2.42E+04 2.11E+04 3.63E+04 2.69E+04 3.22E+04 9.26E+03 2.03E+04 1.83E+04 1.63E+04 6.85E+03 3.13E+04 2.44E+04 3.14E+04 1.34E+04 7.04E+03 1.13E+04 2.40E+04 9.69E+03 2.87E+04 2.09E+04 1.78E+04 2.71E+04 2.63E+04 3.10E+04 1.94E+04 1.48E+04 GM3(d18:1/24:1) 2.03E+04 3.01E+04 4.40E+04 4.42E+04 3.58E+04 3.48E+04 7.09E+04 1.41E+04 3.78E+04 3.61E+04 3.24E+04 5.71E+04 5.55E+04 6.98E+04 6.90E+04 7.53E+04 5.79E+04 3.37E+04 3.16E+04 2.73E+04 3.90E+04 3.71E+04 2.71E+04 6.02E+04 3.82E+04 5.90E+04 1.23E+04 4.25E+04 5.01E+04 3.97E+04 3.44E+04 6.31E+04 5.67E+04 7.00E+04 4.85E+04 8.03E+04 2.55E+04 4.94E+04 2.80E+04 4.26E+04 2.26E+04 7.86E+04 6.35E+04 4.16E+04 3.45E+04 2.33E+04 6.63E+04 3.25E+04 3.43E+04 4.89E+04 4.14E+04 4.01E+04 4.68E+04 4.61E+04 7.14E+04 4.85E+04 5.17E+04 SM(d18:1/12:0) 7.91E+07 5.60E+07 8.86E+07 5.44E+07 5.66E+07 7.31E+07 6.14E+07 4.70E+07 5.45E+07 5.82E+07 3.89E+07 4.44E+07 3.96E+07 3.93E+07 5.36E+07 3.41E+07 8.18E+07 4.97E+07 3.98E+07 8.96E+07 6.46E+07 1.01E+08 6.53E+07 6.11E+07 8.12E+07 6.59E+07 4.06E+07 4.90E+07 6.17E+07 4.20E+07 4.47E+07 4.98E+07 4.31E+07 6.43E+07 4.29E+07 9.46E+07 5.55E+07 4.51E+07 7.47E+07 6.74E+07 9.27E+07 5.98E+07 5.52E+07 7.79E+07 5.63E+07 4.09E+07 4.28E+07 6.08E+07 3.71E+07 4.02E+07 4.63E+07 4.22E+07 5.27E+07 4.12E+07 8.23E+07 5.53E+07 4.26E+07 SM(d18:1/16:0 OH) 1.46E+07 1.71E+07 1.38E+07 1.68E+07 2.22E+07 2.01E+07 1.78E+07 1.42E+07 9.29E+06 1.47E+07 1.19E+07 1.64E+07 2.23E+07 1.20E+07 1.86E+07 1.09E+07 1.89E+07 1.53E+07 1.29E+07 2.02E+07 1.43E+07 1.39E+07 1.84E+07 2.38E+07 1.78E+07 1.70E+07 1.28E+07 1.21E+07 1.31E+07 1.27E+07 1.32E+07 2.15E+07 1.27E+07 2.04E+07 1.15E+07 1.97E+07 1.74E+07 1.35E+07 1.53E+07 1.40E+07 1.23E+07 1.74E+07 2.19E+07 1.85E+07 1.24E+07 1.28E+07 1.35E+07 1.51E+07 1.18E+07 1.50E+07 2.23E+07 1.30E+07 1.84E+07 1.09E+07 1.98E+07 1.66E+07 1.20E+07 SM(d18:1/16:0) 6.46E+06 6.84E+06 7.08E+06 8.39E+06 6.34E+06 7.58E+06 4.32E+06 5.15E+06 5.11E+06 7.33E+06 5.64E+06 6.32E+06 8.90E+06 6.82E+06 6.09E+06 6.15E+06 7.75E+06 5.86E+06 5.15E+06 9.14E+06 5.75E+06 7.01E+06 4.72E+06 6.67E+06 7.12E+06 5.05E+06 6.57E+06 6.57E+06 9.50E+06 8.45E+06 7.98E+06 8.57E+06 6.10E+06 5.51E+06 4.93E+06 7.62E+06 5.17E+06 5.80E+06 5.89E+06 7.55E+06 5.20E+06 5.90E+06 5.06E+06 5.75E+06 3.75E+06 8.97E+06 6.16E+06 5.68E+06 6.75E+06 6.00E+06 8.72E+06 7.56E+06 6.92E+06 7.08E+06 8.79E+06 8.37E+06 4.12E+06 SM(d18:1/16:1 OH) 8.18E+06 9.29E+06 7.47E+06 7.19E+06 6.66E+06 7.00E+06 5.78E+06 1.07E+07 9.44E+06 8.16E+06 8.94E+06 9.75E+06 9.38E+06 6.52E+06 6.79E+06 5.47E+06 6.66E+06 6.43E+06 6.46E+06 9.12E+06 9.48E+06 9.15E+06 9.40E+06 7.96E+06 8.30E+06 5.12E+06 1.03E+07 6.44E+06 6.93E+06 7.31E+06 8.02E+06 1.07E+07 8.86E+06 5.05E+06 6.86E+06 8.87E+06 6.25E+06 5.88E+06 7.23E+06 8.92E+06 5.24E+06 7.14E+06 6.27E+06 6.93E+06 5.38E+06 8.66E+06 8.85E+06 1.05E+07 8.35E+06 5.29E+06 7.78E+06 1.02E+07 8.09E+06 8.40E+06 8.71E+06 6.25E+06 6.14E+06 SM(d18:1/16:1) 1.86E+06 1.81E+06 3.11E+06 2.08E+06 1.64E+06 2.00E+06 2.00E+06 1.95E+06 2.60E+06 1.71E+06 1.44E+06 1.84E+06 2.17E+06 1.92E+06 1.46E+06 1.30E+06 2.25E+06 1.87E+06 1.21E+06 1.86E+06 3.47E+06 2.83E+06 2.05E+06 1.35E+06 2.17E+06 1.50E+06 2.14E+06 1.91E+06 2.16E+06 1.77E+06 1.45E+06 1.93E+06 1.70E+06 1.51E+06 1.87E+06 2.32E+06 2.12E+06 1.48E+06 2.18E+06 2.60E+06 2.30E+06 1.88E+06 1.71E+06 1.74E+06 1.56E+06 2.56E+06 2.08E+06 1.85E+06 1.50E+06 1.41E+06 2.26E+06 1.58E+06 1.53E+06 1.45E+06 1.61E+06 1.97E+06 1.23E+06 SM(d18:1/16:2 OH) 7.31E+06 8.25E+06 8.71E+06 6.15E+06 5.16E+06 6.70E+06 5.50E+06 6.35E+06 6.25E+06 4.47E+06 5.63E+06 5.05E+06 6.21E+06 5.40E+06 5.17E+06 5.03E+06 5.43E+06 5.60E+06 3.96E+06 8.31E+06 7.01E+06 6.65E+06 5.70E+06 4.12E+06 4.69E+06 5.35E+06 5.89E+06 6.54E+06 6.24E+06 5.16E+06 4.15E+06 5.26E+06 6.14E+06 4.78E+06 5.42E+06 5.62E+06 5.42E+06 4.27E+06 6.92E+06 5.00E+06 6.26E+06 6.32E+06 4.95E+06 4.54E+06 4.67E+06 6.83E+06 4.48E+06 5.33E+06 5.01E+06 2.97E+06 5.94E+06 5.06E+06 4.50E+06 6.16E+06 5.60E+06 5.53E+06 4.28E+06 SM(d18:1/16:2) 1.10E+07 7.38E+06 1.06E+07 9.14E+06 8.51E+06 1.01E+07 8.47E+06 7.92E+06 5.93E+06 9.52E+06 5.63E+06 9.48E+06 8.12E+06 6.84E+06 7.66E+06 5.43E+06 1.24E+07 8.44E+06 6.19E+06 1.30E+07 9.09E+06 1.17E+07 9.20E+06 8.56E+06 1.09E+07 8.82E+06 8.02E+06 7.08E+06 7.97E+06 5.84E+06 8.89E+06 8.39E+06 6.82E+06 8.62E+06 5.82E+06 1.36E+07 8.98E+06 7.22E+06 1.08E+07 8.67E+06 1.11E+07 8.89E+06 8.69E+06 1.02E+07 7.22E+06 7.24E+06 6.30E+06 8.19E+06 5.01E+06 7.72E+06 8.16E+06 6.26E+06 7.66E+06 5.47E+06 1.18E+07 8.53E+06 5.86E+06 SM(d18:1/18:0 OH) 1.09E+07 9.69E+06 7.80E+06 9.82E+06 1.50E+07 1.30E+07 9.02E+06 8.86E+06 4.38E+06 1.19E+07 7.91E+06 9.83E+06 1.46E+07 8.21E+06 1.44E+07 7.39E+06 9.72E+06 9.09E+06 7.94E+06 1.23E+07 9.45E+06 6.97E+06 1.02E+07 1.63E+07 1.18E+07 9.55E+06 8.30E+06 6.51E+06 1.05E+07 8.35E+06 7.09E+06 1.43E+07 7.57E+06 1.15E+07 6.18E+06 1.00E+07 8.00E+06 8.25E+06 1.08E+07 9.41E+06 5.95E+06 1.04E+07 1.49E+07 1.42E+07 6.80E+06 6.98E+06 1.03E+07 1.01E+07 6.43E+06 8.06E+06 1.43E+07 9.00E+06 1.19E+07 5.86E+06 9.51E+06 7.87E+06 5.41E+06 SM(d18:1/18:0) 1.82E+07 1.89E+07 1.25E+07 2.14E+07 2.10E+07 2.10E+07 2.02E+07 1.82E+07 1.35E+07 1.86E+07 1.37E+07 1.77E+07 1.95E+07 1.51E+07 1.88E+07 1.44E+07 1.73E+07 1.49E+07 1.43E+07 2.05E+07 1.62E+07 1.29E+07 2.08E+07 2.20E+07 1.90E+07 1.90E+07 1.44E+07 1.48E+07 1.83E+07 1.42E+07 1.56E+07 2.02E+07 1.65E+07 2.00E+07 1.47E+07 1.75E+07 1.58E+07 1.50E+07 1.84E+07 1.65E+07 1.25E+07 2.22E+07 2.22E+07 2.05E+07 1.41E+07 1.50E+07 1.60E+07 1.92E+07 1.37E+07 1.65E+07 2.09E+07 1.63E+07 1.88E+07 1.61E+07 1.72E+07 1.60E+07 1.32E+07 SM(d18:1/18:1 OH) 8.05E+07 7.97E+07 6.15E+07 8.73E+07 9.86E+07 9.30E+07 8.20E+07 6.56E+07 4.57E+07 7.93E+07 5.99E+07 7.30E+07 1.06E+08 5.59E+07 9.24E+07 5.68E+07 7.54E+07 6.48E+07 5.72E+07 1.04E+08 6.66E+07 6.57E+07 9.11E+07 9.86E+07 8.18E+07 8.56E+07 5.56E+07 6.46E+07 7.50E+07 6.02E+07 6.23E+07 1.02E+08 5.79E+07 9.33E+07 5.52E+07 7.87E+07 6.96E+07 5.88E+07 8.99E+07 6.81E+07 6.05E+07 9.00E+07 9.79E+07 9.16E+07 6.09E+07 5.50E+07 6.93E+07 7.86E+07 5.94E+07 6.87E+07 1.06E+08 5.65E+07 9.38E+07 5.71E+07 7.96E+07 6.92E+07 5.07E+07 SM(d18:1/18:1) 1.98E+07 2.67E+07 2.41E+07 3.29E+07 3.25E+07 2.53E+07 2.50E+07 2.89E+07 1.87E+07 2.29E+07 1.50E+07 2.66E+07 2.64E+07 2.21E+07 2.13E+07 1.94E+07 2.32E+07 2.33E+07 2.04E+07 2.66E+07 2.90E+07 2.70E+07 3.53E+07 3.01E+07 2.69E+07 2.82E+07 2.59E+07 2.52E+07 2.22E+07 1.64E+07 2.57E+07 2.90E+07 2.21E+07 2.50E+07 2.10E+07 2.38E+07 2.67E+07 2.23E+07 2.18E+07 3.07E+07 2.51E+07 3.34E+07 3.21E+07 2.84E+07 2.37E+07 2.60E+07 2.19E+07 2.39E+07 1.54E+07 2.63E+07 2.76E+07 2.08E+07 2.08E+07 2.10E+07 2.35E+07 2.48E+07 2.01E+07 SM(d18:1/18:2 OH) 1.09E+06 1.26E+06 1.36E+06 1.46E+06 1.71E+06 1.16E+06 1.14E+06 1.14E+06 7.91E+05 1.15E+06 7.30E+05 1.41E+06 1.63E+06 7.07E+05 1.10E+06 5.63E+05 1.27E+06 1.24E+06 9.45E+05 1.52E+06 1.36E+06 1.77E+06 1.70E+06 1.63E+06 1.17E+06 1.72E+06 9.52E+05 1.16E+06 1.06E+06 7.06E+05 1.39E+06 1.88E+06 8.00E+05 1.35E+06 8.00E+05 1.27E+06 1.42E+06 9.85E+05 1.21E+06 1.31E+06 1.68E+06 1.71E+06 1.82E+06 1.16E+06 1.17E+06 9.27E+05 1.04E+06 1.20E+06 6.97E+05 1.20E+06 1.63E+06 7.64E+05 1.21E+06 8.07E+05 1.38E+06 1.34E+06 9.21E+05 SM(d18:1/18:2) 4.86E+07 4.85E+07 6.17E+07 5.82E+07 5.94E+07 5.28E+07 4.81E+07 5.19E+07 3.40E+07 4.85E+07 3.95E+07 5.33E+07 5.59E+07 5.18E+07 4.04E+07 3.40E+07 5.66E+07 5.77E+07 3.99E+07 5.83E+07 5.73E+07 6.66E+07 6.13E+07 5.78E+07 5.84E+07 5.40E+07 5.71E+07 4.42E+07 4.50E+07 3.78E+07 4.86E+07 4.16E+07 5.05E+07 4.42E+07 3.53E+07 6.05E+07 6.36E+07 4.24E+07 5.18E+07 6.20E+07 6.58E+07 5.81E+07 5.83E+07 5.29E+07 5.11E+07 5.06E+07 4.02E+07 4.45E+07 3.69E+07 4.39E+07 5.41E+07 4.87E+07 3.73E+07 3.37E+07 5.30E+07 5.82E+07 3.64E+07 SM(d18:1/20:0 OH) 2.86E+07 2.68E+07 3.22E+07 3.39E+07 2.90E+07 3.22E+07 2.57E+07 2.45E+07 2.09E+07 3.50E+07 1.84E+07 2.55E+07 3.06E+07 2.84E+07 3.06E+07 2.30E+07 3.43E+07 3.30E+07 2.36E+07 3.76E+07 2.79E+07 3.17E+07 3.53E+07 3.06E+07 3.18E+07 2.82E+07 2.49E+07 2.88E+07 3.05E+07 1.82E+07 2.52E+07 3.10E+07 2.78E+07 3.19E+07 2.24E+07 3.66E+07 3.39E+07 2.61E+07 3.28E+07 2.78E+07 2.97E+07 3.38E+07 3.02E+07 3.38E+07 2.39E+07 2.33E+07 2.73E+07 3.29E+07 1.74E+07 2.26E+07 3.24E+07 2.77E+07 2.96E+07 2.19E+07 3.25E+07 3.34E+07 2.28E+07 SM(d18:1/20:0) 1.56E+07 1.34E+07 7.09E+06 1.52E+07 1.42E+07 1.64E+07 1.32E+07 9.56E+06 8.88E+06 1.67E+07 9.23E+06 1.16E+07 1.33E+07 1.03E+07 1.36E+07 1.11E+07 1.17E+07 9.78E+06 1.05E+07 2.43E+07 1.16E+07 8.38E+06 1.45E+07 1.54E+07 1.35E+07 1.10E+07 8.79E+06 9.85E+06 1.50E+07 9.71E+06 1.09E+07 1.29E+07 1.09E+07 1.43E+07 1.10E+07 1.19E+07 1.07E+07 1.10E+07 1.99E+07 1.07E+07 6.38E+06 1.53E+07 1.41E+07 1.62E+07 7.71E+06 9.17E+06 1.08E+07 1.63E+07 9.36E+06 1.11E+07 1.37E+07 1.11E+07 1.47E+07 1.27E+07 1.20E+07 1.10E+07 8.66E+06 SM(d18:1/20:1 OH) 9.36E+07 7.38E+07 5.83E+07 8.76E+07 8.21E+07 9.51E+07 7.58E+07 4.90E+07 4.56E+07 1.09E+08 5.72E+07 7.08E+07 9.85E+07 6.24E+07 8.43E+07 6.50E+07 8.88E+07 6.53E+07 6.28E+07 1.10E+08 6.06E+07 6.01E+07 8.61E+07 8.82E+07 7.78E+07 7.57E+07 5.14E+07 5.58E+07 9.69E+07 5.53E+07 5.43E+07 9.15E+07 6.12E+07 7.67E+07 6.54E+07 8.68E+07 6.63E+07 6.54E+07 1.04E+08 6.18E+07 5.27E+07 8.58E+07 8.40E+07 8.93E+07 5.23E+07 4.89E+07 6.63E+07 1.03E+08 5.41E+07 6.23E+07 9.95E+07 6.34E+07 8.76E+07 6.51E+07 8.37E+07 6.45E+07 5.60E+07 SM(d18:1/20:1) 3.77E+05 1.73E+05 2.13E+05 3.38E+05 1.65E+05 2.34E+05 1.50E+05 1.22E+05 1.51E+05 2.15E+05 3.64E+05 2.90E+05 9.74E+04 2.63E+05 2.27E+05 1.87E+05 1.61E+05 1.74E+05 2.21E+05 5.20E+05 2.82E+05 4.37E+05 6.49E+05 4.39E+05 4.50E+05 3.38E+05 1.64E+05 3.05E+05 3.88E+05 3.89E+05 5.83E+05 3.37E+05 3.42E+05 3.53E+05 2.89E+05 1.73E+05 2.53E+05 2.78E+05 2.90E+05 2.64E+05 3.20E+05 2.62E+05 2.61E+05 2.88E+05 3.28E+05 3.13E+05 3.20E+05 1.68E+05 2.84E+05 3.14E+05 2.69E+05 3.88E+05 1.91E+05 2.02E+05 1.47E+05 3.57E+05 2.62E+05 SM(d18:1/20:2 OH) 4.70E+07 4.96E+07 5.27E+07 6.61E+07 5.72E+07 5.93E+07 4.66E+07 3.62E+07 2.95E+07 5.31E+07 3.73E+07 5.20E+07 6.63E+07 3.45E+07 6.18E+07 3.88E+07 4.95E+07 4.43E+07 3.56E+07 8.30E+07 4.83E+07 5.88E+07 5.97E+07 6.12E+07 5.37E+07 5.23E+07 3.75E+07 4.46E+07 4.89E+07 3.16E+07 5.58E+07 7.23E+07 3.80E+07 6.06E+07 3.70E+07 5.03E+07 4.53E+07 3.74E+07 7.15E+07 5.08E+07 4.70E+07 6.48E+07 5.98E+07 6.18E+07 4.37E+07 3.86E+07 4.12E+07 5.44E+07 3.52E+07 5.46E+07 6.82E+07 3.44E+07 5.24E+07 3.94E+07 5.38E+07 4.74E+07 3.27E+07 SM(d18:1/20:2) 8.73E+05 8.47E+05 8.44E+05 7.29E+05 8.95E+05 8.09E+05 7.63E+05 8.01E+05 1.08E+06 1.25E+06 7.69E+05 9.61E+05 1.07E+06 8.84E+05 6.64E+05 6.08E+05 6.54E+05 6.56E+05 7.06E+05 7.12E+05 1.40E+06 1.24E+06 8.48E+05 7.48E+05 6.46E+05 6.82E+05 7.39E+05 9.63E+05 1.06E+06 9.74E+05 6.02E+05 8.90E+05 9.30E+05 4.96E+05 8.42E+05 7.91E+05 9.01E+05 5.22E+05 9.07E+05 9.36E+05 6.45E+05 8.03E+05 6.40E+05 7.59E+05 6.28E+05 7.19E+05 1.04E+06 6.89E+05 7.81E+05 7.06E+05 1.05E+06 8.42E+05 7.28E+05 7.18E+05 8.22E+05 7.37E+05 7.38E+05 SM(d18:1/22:0 OH) 2.10E+07 2.28E+07 2.08E+07 2.72E+07 2.60E+07 2.48E+07 2.38E+07 1.76E+07 1.82E+07 2.65E+07 1.52E+07 2.18E+07 2.69E+07 2.18E+07 2.50E+07 2.08E+07 2.33E+07 2.35E+07 2.07E+07 2.85E+07 2.31E+07 2.13E+07 2.69E+07 2.77E+07 2.31E+07 2.48E+07 1.63E+07 1.86E+07 2.55E+07 1.52E+07 1.93E+07 2.53E+07 2.35E+07 2.52E+07 2.12E+07 2.57E+07 2.48E+07 2.14E+07 2.49E+07 2.22E+07 1.99E+07 2.70E+07 2.57E+07 2.51E+07 1.78E+07 1.53E+07 1.94E+07 2.63E+07 1.50E+07 1.99E+07 2.62E+07 2.33E+07 2.39E+07 2.06E+07 2.55E+07 2.54E+07 1.88E+07 SM(d18:1/22:0) 2.86E+06 2.94E+06 1.82E+06 3.35E+06 3.26E+06 3.38E+06 2.53E+06 1.89E+06 1.82E+06 3.51E+06 2.34E+06 3.02E+06 3.15E+06 2.68E+06 3.30E+06 2.51E+06 2.50E+06 2.39E+06 2.63E+06 4.00E+06 2.70E+06 1.71E+06 3.19E+06 3.42E+06 2.77E+06 2.82E+06 1.98E+06 2.37E+06 3.07E+06 2.48E+06 2.58E+06 2.73E+06 2.64E+06 2.78E+06 2.44E+06 2.45E+06 2.25E+06 2.24E+06 3.47E+06 2.46E+06 1.57E+06 3.38E+06 2.93E+06 3.07E+06 1.88E+06 1.78E+06 2.38E+06 3.16E+06 2.24E+06 2.85E+06 3.06E+06 2.73E+06 3.36E+06 2.62E+06 2.57E+06 2.19E+06 2.25E+06 SM(d18:1/22:1) 2.13E+07 2.29E+07 1.72E+07 2.48E+07 2.32E+07 2.29E+07 2.15E+07 1.43E+07 1.53E+07 2.23E+07 1.32E+07 2.17E+07 1.88E+07 1.74E+07 2.11E+07 1.72E+07 1.79E+07 1.73E+07 1.77E+07 3.02E+07 2.03E+07 1.66E+07 2.61E+07 2.39E+07 1.78E+07 2.22E+07 1.34E+07 2.03E+07 2.13E+07 1.48E+07 2.01E+07 2.06E+07 1.90E+07 2.27E+07 1.87E+07 1.68E+07 1.82E+07 1.83E+07 2.55E+07 2.14E+07 1.55E+07 2.48E+07 2.31E+07 2.23E+07 1.64E+07 1.44E+07 1.97E+07 2.25E+07 1.39E+07 2.09E+07 2.02E+07 1.89E+07 2.03E+07 1.82E+07 1.78E+07 1.74E+07 1.60E+07 SM(d18:1/22:2 OH) 3.76E+06 4.93E+06 3.41E+06 5.00E+06 5.21E+06 3.98E+06 4.64E+06 2.82E+06 2.91E+06 4.45E+06 2.66E+06 4.62E+06 5.42E+06 3.03E+06 3.87E+06 3.18E+06 4.03E+06 3.27E+06 3.38E+06 4.73E+06 3.83E+06 3.38E+06 4.97E+06 5.28E+06 3.61E+06 4.49E+06 2.35E+06 3.97E+06 4.40E+06 2.61E+06 3.85E+06 5.62E+06 3.45E+06 4.07E+06 3.36E+06 3.47E+06 3.40E+06 3.34E+06 4.19E+06 4.57E+06 3.17E+06 5.15E+06 4.88E+06 4.03E+06 3.18E+06 2.40E+06 4.29E+06 4.32E+06 2.72E+06 4.43E+06 5.83E+06 3.37E+06 3.92E+06 3.59E+06 3.80E+06 3.02E+06 2.87E+06 SM(d18:1/22:2) 2.47E+05 6.25E+05 3.85E+05 2.59E+05 2.91E+05 2.08E+05 2.50E+05 3.85E+05 2.55E+05 1.96E+05 2.56E+05 2.69E+05 3.61E+05 2.08E+05 2.24E+05 2.21E+05 3.19E+05 2.76E+05 1.10E+05 2.36E+05 3.93E+05 3.03E+05 3.25E+05 2.89E+05 2.02E+05 3.06E+05 2.97E+05 2.71E+05 3.19E+05 3.08E+05 2.31E+05 4.23E+05 2.89E+05 2.41E+05 2.92E+05 3.24E+05 2.90E+05 1.82E+05 3.47E+05 4.24E+05 2.41E+05 2.56E+05 2.52E+05 1.93E+05 3.07E+05 3.18E+05 2.67E+05 2.64E+05 2.14E+05 1.59E+05 3.96E+05 2.49E+05 3.82E+05 2.70E+05 4.16E+05 3.12E+05 2.58E+05 SM(d18:1/23:0) or SM(d18:1/22:1 OH) 3.11E+07 3.73E+07 2.27E+07 3.51E+07 4.05E+07 3.80E+07 3.35E+07 2.47E+07 1.87E+07 3.70E+07 2.87E+07 3.39E+07 5.25E+07 2.89E+07 4.11E+07 2.61E+07 2.89E+07 2.87E+07 2.90E+07 3.96E+07 3.11E+07 2.43E+07 3.27E+07 5.09E+07 2.92E+07 3.53E+07 2.35E+07 2.88E+07 3.75E+07 2.88E+07 2.76E+07 4.74E+07 3.18E+07 2.77E+07 2.55E+07 2.80E+07 2.44E+07 2.81E+07 3.58E+07 3.04E+07 2.20E+07 3.64E+07 3.75E+07 3.66E+07 2.42E+07 2.37E+07 3.45E+07 3.68E+07 2.94E+07 3.20E+07 4.97E+07 3.32E+07 4.36E+07 2.75E+07 2.89E+07 2.76E+07 2.67E+07 SM(d18:1/24:0 OH) 5.00E+06 7.56E+06 4.42E+06 8.37E+06 8.01E+06 5.79E+06 6.59E+06 4.95E+06 3.82E+06 7.38E+06 5.97E+06 6.31E+06 8.46E+06 7.15E+06 6.18E+06 6.83E+06 6.36E+06 7.18E+06 6.09E+06 7.30E+06 6.56E+06 4.39E+06 7.94E+06 8.96E+06 5.47E+06 6.30E+06 4.26E+06 5.27E+06 6.90E+06 6.13E+06 5.62E+06 7.52E+06 7.94E+06 6.07E+06 7.92E+06 6.33E+06 7.41E+06 6.26E+06 5.96E+06 6.39E+06 4.14E+06 8.15E+06 7.91E+06 5.49E+06 4.52E+06 4.25E+06 5.74E+06 7.01E+06 5.21E+06 6.30E+06 8.24E+06 7.50E+06 6.15E+06 6.64E+06 5.71E+06 7.51E+06 5.19E+06 SM(d18:1/24:0) 5.08E+07 8.11E+07 3.75E+07 6.05E+07 7.51E+07 5.80E+07 6.58E+07 5.17E+07 3.94E+07 5.81E+07 7.43E+07 5.65E+07 8.48E+07 6.78E+07 7.10E+07 5.46E+07 4.37E+07 5.36E+07 5.58E+07 6.09E+07 6.47E+07 3.63E+07 5.56E+07 7.98E+07 4.62E+07 6.64E+07 4.90E+07 5.69E+07 5.66E+07 8.08E+07 4.63E+07 7.77E+07 7.68E+07 4.75E+07 5.27E+07 4.31E+07 4.84E+07 5.42E+07 5.67E+07 5.68E+07 3.28E+07 6.19E+07 7.12E+07 5.90E+07 4.98E+07 4.59E+07 7.44E+07 5.74E+07 8.04E+07 5.60E+07 8.11E+07 7.92E+07 7.64E+07 5.74E+07 4.62E+07 5.21E+07 5.28E+07 SM(d18:1/24:1) 9.89E+06 1.86E+07 7.99E+06 1.49E+07 1.58E+07 1.21E+07 1.50E+07 1.14E+07 1.01E+07 1.22E+07 1.44E+07 1.42E+07 1.80E+07 1.41E+07 1.51E+07 1.21E+07 1.07E+07 1.06E+07 1.14E+07 1.35E+07 1.42E+07 8.12E+06 1.53E+07 1.85E+07 9.72E+06 1.51E+07 8.99E+06 1.46E+07 1.22E+07 1.50E+07 1.22E+07 1.72E+07 1.60E+07 1.22E+07 1.24E+07 1.02E+07 1.04E+07 1.13E+07 1.15E+07 1.30E+07 7.48E+06 1.58E+07 1.62E+07 1.29E+07 1.09E+07 9.46E+06 1.85E+07 1.22E+07 1.54E+07 1.42E+07 1.72E+07 1.58E+07 1.56E+07 1.28E+07 1.02E+07 1.06E+07 1.07E+07 SM(d18:1/24:2 OH) 3.45E+05 3.98E+05 4.25E+05 5.43E+05 5.55E+05 4.04E+05 3.14E+05 3.39E+05 3.62E+05 4.33E+05 2.30E+05 5.72E+05 3.68E+05 4.47E+05 3.90E+05 3.72E+05 5.70E+05 4.43E+05 4.26E+05 4.90E+05 3.49E+05 3.82E+05 5.98E+05 4.35E+05 4.18E+05 4.37E+05 2.52E+05 4.11E+05 4.52E+05 1.84E+05 4.95E+05 4.60E+05 4.36E+05 4.12E+05 3.90E+05 4.96E+05 4.94E+05 3.79E+05 4.14E+05 4.68E+05 3.31E+05 5.40E+05 4.40E+05 3.80E+05 3.43E+05 2.49E+05 1.00E+05 4.69E+05 2.15E+05 4.51E+05 4.64E+05 4.35E+05 4.00E+05 4.64E+05 5.61E+05 4.74E+05 3.79E+05 SM(d18:1/24:2) 4.43E+06 7.56E+06 5.22E+06 6.70E+06 6.80E+06 5.24E+06 5.88E+06 4.39E+06 5.04E+06 5.62E+06 4.50E+06 6.90E+06 6.89E+06 5.69E+06 5.43E+06 4.92E+06 4.94E+06 5.20E+06 5.24E+06 5.57E+06 6.57E+06 6.02E+06 8.12E+06 7.35E+06 4.82E+06 7.61E+06 3.60E+06 6.95E+06 5.41E+06 4.75E+06 6.60E+06 7.44E+06 6.16E+06 5.68E+06 5.18E+06 4.73E+06 5.32E+06 5.50E+06 5.07E+06 6.71E+06 5.83E+06 7.35E+06 6.76E+06 5.45E+06 5.76E+06 3.74E+06 6.42E+06 5.90E+06 4.92E+06 6.95E+06 7.12E+06 5.63E+06 5.74E+06 5.55E+06 5.32E+06 5.31E+06 5.33E+06 SM(d18:1/25:0) or SM(d18:1/24:1 OH) 9.26E+06 1.40E+07 8.24E+06 1.35E+07 1.48E+07 1.12E+07 1.23E+07 7.58E+06 7.08E+06 1.12E+07 1.03E+07 1.06E+07 1.45E+07 1.13E+07 1.36E+07 8.96E+06 1.15E+07 1.24E+07 1.04E+07 1.35E+07 1.21E+07 8.24E+06 1.40E+07 1.66E+07 9.68E+06 1.24E+07 6.78E+06 1.10E+07 1.41E+07 1.04E+07 1.04E+07 1.60E+07 1.20E+07 1.26E+07 1.37E+07 1.15E+07 1.36E+07 1.08E+07 1.23E+07 1.30E+07 7.42E+06 1.39E+07 1.53E+07 1.10E+07 8.39E+06 6.55E+06 1.16E+07 1.14E+07 9.82E+06 1.12E+07 1.58E+07 1.15E+07 1.41E+07 1.03E+07 1.19E+07 1.26E+07 9.06E+06 SM(d18:1/26:0 OH) 3.95E+05 4.94E+05 4.02E+05 3.15E+05 3.10E+05 3.13E+05 5.65E+05 7.14E+05 5.30E+05 4.00E+05 2.99E+05 3.19E+05 4.55E+05 3.20E+05 3.56E+05 3.54E+05 5.45E+05 3.97E+05 3.03E+05 5.60E+05 5.33E+05 3.77E+05 3.07E+05 3.40E+05 3.92E+05 5.63E+05 5.74E+05 3.72E+05 4.45E+05 2.97E+05 2.81E+05 5.20E+05 3.55E+05 4.43E+05 3.18E+05 4.75E+05 4.64E+05 3.46E+05 4.93E+05 5.65E+05 4.01E+05 3.82E+05 2.86E+05 3.55E+05 4.33E+05 5.52E+05 4.78E+05 3.65E+05 3.59E+05 1.34E+05 6.01E+05 3.13E+05 2.92E+05 4.23E+05 4.00E+05 4.69E+05 2.33E+05 SM(d18:1/26:0) 8.78E+04 1.27E+05 1.21E+05 8.65E+04 6.96E+04 8.92E+04 8.24E+04 1.33E+05 1.38E+05 1.18E+05 7.03E+04 6.91E+04 1.32E+05 9.25E+04 6.83E+04 6.63E+04 8.92E+04 8.83E+04 5.00E+04 1.06E+05 1.39E+05 1.08E+05 7.97E+04 7.04E+04 8.52E+04 9.37E+04 1.12E+05 9.34E+04 9.58E+04 7.91E+04 5.80E+04 1.10E+05 9.34E+04 7.89E+04 6.72E+04 1.27E+05 9.45E+04 7.17E+04 1.06E+05 1.30E+05 1.18E+05 1.02E+05 5.71E+04 5.88E+04 8.85E+04 8.89E+04 9.38E+04 8.94E+04 7.90E+04 2.43E+04 1.30E+05 8.45E+04 7.19E+04 7.60E+04 9.28E+04 9.34E+04 6.81E+04 SM(d18:1/26:1 OH) 1.23E+05 2.10E+05 1.37E+05 9.86E+04 7.32E+04 1.18E+05 1.57E+05 2.00E+05 2.32E+05 1.06E+05 1.05E+05 1.15E+05 1.55E+05 8.64E+04 1.90E+05 1.04E+05 1.22E+05 1.19E+05 9.79E+04 1.33E+05 1.49E+05 9.79E+04 1.25E+05 9.17E+04 1.14E+05 1.26E+05 1.50E+05 1.72E+05 1.22E+05 8.68E+04 9.54E+04 1.48E+05 1.17E+05 2.10E+05 9.92E+04 1.45E+05 7.56E+04 9.49E+04 1.27E+05 1.49E+05 1.53E+05 1.19E+05 7.57E+04 9.45E+04 9.07E+04 1.31E+05 1.56E+05 7.48E+04 9.25E+04 6.39E+04 1.21E+05 8.42E+04 1.52E+05 1.10E+05 1.20E+05 1.23E+05 7.88E+04 SM(d18:1/26:1) 1.59E+06 3.09E+06 1.59E+06 2.28E+06 2.66E+06 1.88E+06 2.17E+06 1.03E+06 1.10E+06 2.48E+06 2.51E+06 2.06E+06 2.87E+06 2.02E+06 2.63E+06 1.72E+06 2.47E+06 2.01E+06 1.67E+06 1.77E+06 2.23E+06 1.72E+06 2.01E+06 3.10E+06 1.82E+06 2.21E+06 1.30E+06 2.01E+06 2.73E+05 3.23E+06 1.84E+06 2.67E+06 2.33E+06 2.38E+06 1.86E+06 2.76E+06 1.94E+06 1.70E+06 1.47E+06 1.88E+06 1.13E+06 2.46E+06 2.41E+06 2.15E+06 1.37E+06 1.12E+06 2.40E+06 2.43E+06 2.68E+06 2.05E+06 2.89E+06 2.06E+06 2.98E+06 2.02E+06 2.43E+06 2.16E+06 1.41E+06 SM(d18:1/26:2 OH) 2.68E+06 3.42E+06 2.08E+06 3.00E+06 2.35E+06 2.51E+06 2.57E+06 3.30E+06 1.81E+06 6.00E+06 2.53E+06 2.53E+06 2.79E+06 2.47E+06 6.04E+06 1.98E+06 5.13E+06 4.05E+06 2.65E+06 2.74E+06 4.50E+06 2.13E+06 2.92E+06 2.36E+06 2.70E+06 2.85E+06 3.98E+06 1.78E+06 5.22E+06 2.22E+06 2.23E+06 2.99E+06 2.40E+06 5.97E+06 1.81E+06 5.40E+06 3.93E+06 3.17E+06 2.30E+06 3.70E+06 2.28E+06 3.17E+06 2.43E+06 2.29E+06 2.53E+06 3.74E+06 1.35E+06 5.22E+06 1.90E+06 2.00E+06 2.87E+06 2.17E+06 5.17E+06 1.86E+06 5.07E+06 3.48E+06 2.92E+06 SM(d18:1/26:2) 2.53E+06 3.58E+06 2.38E+06 2.24E+06 3.01E+06 1.70E+06 2.26E+06 1.48E+06 1.35E+06 4.11E+06 3.18E+06 1.57E+06 3.70E+06 1.99E+06 2.09E+06 1.89E+06 4.33E+06 2.46E+06 1.64E+06 2.65E+06 2.47E+06 3.04E+06 2.07E+06 3.17E+06 1.65E+06 2.45E+06 1.46E+06 2.05E+06 4.01E+06 3.52E+06 1.88E+06 3.92E+06 1.93E+06 2.23E+06 1.99E+06 4.69E+06 2.45E+06 1.79E+06 2.29E+06 2.38E+06 2.84E+06 2.38E+06 3.02E+06 2.12E+06 1.90E+06 1.48E+06 2.66E+06 3.99E+06 3.17E+06 1.98E+06 3.73E+06 1.95E+06 2.31E+06 1.97E+06 4.18E+06 2.35E+06 1.62E+06 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name KEGG ID PubChem ID HMDB ChEBI DeoxyCer(m18:1/16:0) NA NA NA NA DeoxyCer(m18:1/18:0) NA NA NA NA DeoxyCer(m18:1/20:0) NA NA NA NA DeoxyCer(m18:1/22:0) NA NA NA NA DeoxyCer(m18:1/24:0) NA NA NA NA DeoxyCer(m18:1/24:1) NA NA NA NA DeoxyCer(m18:1/26:0) NA NA NA NA DeoxyCer(m18:1/26:1) NA NA NA NA DeoxydihydroCer(m18:0/16:0) NA NA NA NA DeoxydihydroCer(m18:0/18:0) NA NA NA NA DeoxydihydroCer(m18:0/20:0) NA NA NA NA DeoxydihydroCer(m18:0/22:0) NA NA NA NA DeoxydihydroCer(m18:0/24:0) NA NA NA NA DeoxydihydroCer(m18:0/24:1) NA NA NA NA DeoxydihydroCer(m18:0/26:0) NA NA NA NA DeoxydihydroCer(m18:0/26:1) NA NA NA NA GD2(d18:1/16:0) NA 44262068 NA NA GD2(d18:1/18:0) NA 44262069 NA NA GD2(d18:1/18:1) NA NA NA NA GD2(d18:1/19:0) NA NA NA NA GD2(d18:1/20:0) NA 44262070 NA NA GD2(d18:1/21:0) NA NA NA NA GD2(d18:1/22:0) NA 44262071 NA NA GD3(d18:1/14:0) NA NA NA NA GD3(d18:1/15:0) NA NA NA NA GD3(d18:1/16:0) NA 44262044 NA NA GD3(d18:1/16:1) NA NA NA NA GD3(d18:1/17:0) NA NA NA NA GD3(d18:1/18:0) NA 44262045 NA NA GD3(d18:1/18:1) NA NA NA NA GD3(d18:1/19:0) NA NA NA NA GD3(d18:1/20:0) NA 44262046 NA NA GD3(d18:1/21:0) NA NA NA NA GD3(d18:1/22:0) NA 44262047 NA NA GD3(d18:1/23:0) NA NA NA NA GD3(d18:1/24:0) NA 44262048 NA NA GD3(d18:1/25:0) NA NA NA NA GM2(d18:1/16:0) NA 44262060 NA NA GM2(d18:1/16:1) NA NA NA NA GM2(d18:1/18:1) NA NA NA NA GM2(d18:1/20:0) NA 44262062 NA NA GM3(d18:1/16:0) NA 44262036 NA NA GM3(d18:1/16:1) NA NA NA NA GM3(d18:1/18:0) NA 44262037 NA NA GM3(d18:1/18:1) NA NA NA NA GM3(d18:1/20:0) NA 44262038 NA NA GM3(d18:1/22:0) NA 44262039 NA NA GM3(d18:1/24:0) NA 44262040 NA NA GM3(d18:1/24:1) NA 44262042 NA NA SM(d18:1/12:0) C00550 44260123 HMDB0012096 17636 SM(d18:1/16:0 OH) NA NA NA NA SM(d18:1/16:0) C00550 5283590 HMDB0010169 17636 SM(d18:1/16:1 OH) NA NA NA NA SM(d18:1/16:1) NA 52931145 NA 64487 SM(d18:1/16:2 OH) NA NA NA NA SM(d18:1/16:2) NA NA NA NA SM(d18:1/18:0 OH) NA NA NA NA SM(d18:1/18:0) C00550 5283588 HMDB0001348 17636 SM(d18:1/18:1 OH) NA NA NA NA SM(d18:1/18:1) C00550 53481366 HMDB0012100 17636 SM(d18:1/18:2 OH) NA NA NA NA SM(d18:1/18:2) NA NA NA NA SM(d18:1/20:0 OH) NA NA NA NA SM(d18:1/20:0) C00550 44260124 HMDB0012102 113818 SM(d18:1/20:1 OH) NA NA NA NA SM(d18:1/20:1) NA 52931179 NA 90494 SM(d18:1/20:2 OH) NA NA NA NA SM(d18:1/20:2) NA NA NA NA SM(d18:1/22:0 OH) NA NA NA NA SM(d18:1/22:0) C00550 44260125 HMDB0012103 17636 SM(d18:1/22:1) NA NA NA NA SM(d18:1/22:2 OH) NA NA NA NA SM(d18:1/22:2) NA NA NA NA SM(d18:1/23:0) or SM(d18:1/22:1 OH) NA NA NA NA SM(d18:1/24:0 OH) NA NA NA NA SM(d18:1/24:0) NA 5283595 HMDB0011697 NA SM(d18:1/24:1) C00550 44260126 HMDB0012107 17636 SM(d18:1/24:2 OH) NA NA NA NA SM(d18:1/24:2) NA NA NA NA SM(d18:1/25:0) or SM(d18:1/24:1 OH) NA NA NA NA SM(d18:1/26:0 OH) NA NA NA NA SM(d18:1/26:0) C00550 5283597 HMDB0011698 NA SM(d18:1/26:1 OH) NA NA NA NA SM(d18:1/26:1) C00550 44260128 HMDB0013461 84476 SM(d18:1/26:2 OH) NA NA NA NA SM(d18:1/26:2) NA NA NA NA METABOLITES_END #END