#METABOLOMICS WORKBENCH yli_20211223_093409 DATATRACK_ID:3006 STUDY_ID:ST002050 ANALYSIS_ID:AN003337
VERSION                          	1
CREATED_ON                       	09-06-2023
#PROJECT
PR:PROJECT_TITLE                 	Perfluoroalkyl Compounds and Child Metabolic Health (Healthy Start Cohort)
PR:PROJECT_TYPE                  	Metabolomics
PR:PROJECT_SUMMARY               	The project Perfluoroalkyl Compounds and Child Metabolic Health is funded by the
PR:PROJECT_SUMMARY               	NIH Environmental influences on Child Health Outcomes (ECHO) program, and uses
PR:PROJECT_SUMMARY               	data from the Healthy Start and Project Viva ECHO cohorts. This project will
PR:PROJECT_SUMMARY               	examine associations of untargeted metabolomics data acquired from cord blood
PR:PROJECT_SUMMARY               	with prenatal PFAS exposure and the effect on infant/child metabolic health.
PR:INSTITUTE                     	NC HHEAR Hub
PR:DEPARTMENT                    	Untargeted Analysis
PR:LABORATORY                    	Sumner/Li Lab
PR:LAST_NAME                     	Sumner, Li
PR:FIRST_NAME                    	Susan, Yuan
PR:ADDRESS                       	500 Laureate Way, Kannapolis, NC 28081
PR:EMAIL                         	susan_sumner@unc.edu, yuanyli4@unc.edu
PR:PHONE                         	9196224456
PR:FUNDING_SOURCE                	This research was supported by the Environmental influences on Child Health
PR:FUNDING_SOURCE                	Outcomes (ECHO) program, Office of The Director, National Institutes of Health.
PR:FUNDING_SOURCE                	The content is solely the responsibility of the authors and does not necessarily
PR:FUNDING_SOURCE                	represent the official views of the National Institutes of Health. Healthy Start
PR:FUNDING_SOURCE                	is an ECHO cohort which is supported by the following ECHO Program
PR:FUNDING_SOURCE                	Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute,
PR:FUNDING_SOURCE                	Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data
PR:FUNDING_SOURCE                	Analysis Center: Johns Hopkins University Bloomberg School of Public Health,
PR:FUNDING_SOURCE                	Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North
PR:FUNDING_SOURCE                	Carolina: Parker CB; U24 OD023382 North Carolina Human Health Exposure Analysis
PR:FUNDING_SOURCE                	Resource Hub: Research Triangle Institute: Fennell T, University of North
PR:FUNDING_SOURCE                	Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du
PR:FUNDING_SOURCE                	X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center:
PR:FUNDING_SOURCE                	Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
PR:DOI                           	http://dx.doi.org/10.21228/M86697
#STUDY
ST:STUDY_TITLE                   	Perfluoroalkyl Compounds and Child Metabolic Health (Project Viva)
ST:STUDY_SUMMARY                 	Project Viva: Pregnant women were enrolled in Project Viva between 1999 and 2002
ST:STUDY_SUMMARY                 	at their first prenatal visit at one of 8 obstetric clinics of Atrius Harvard
ST:STUDY_SUMMARY                 	Vanguard Medical Associates, a multispecialty group practice in eastern
ST:STUDY_SUMMARY                 	Massachusetts. Eligible mothers were fluent in English, had singleton
ST:STUDY_SUMMARY                 	gestations, were <22 weeks gestation, and had no plans to move away from the
ST:STUDY_SUMMARY                 	study area. Research staff performed in-person study visits with participating
ST:STUDY_SUMMARY                 	mothers in the first (median gestational age 9.9 weeks) and second (median
ST:STUDY_SUMMARY                 	gestational age 28.1 weeks) trimesters of pregnancy, and with mothers and
ST:STUDY_SUMMARY                 	children during the first few days after delivery, during infancy (median age
ST:STUDY_SUMMARY                 	6.3 months), in early childhood (median age 3.3 years), mid-childhood (median
ST:STUDY_SUMMARY                 	age 7.7 years), and adolescence (median age13 years). In this analysis, we will
ST:STUDY_SUMMARY                 	use data from 188 mother-child pairs in Project Viva with available information
ST:STUDY_SUMMARY                 	on prenatal PFAS concentrations, available umbilical cord serum samples at
ST:STUDY_SUMMARY                 	delivery, and outcomes of interest. Please contact Nicole Bornkamp at
ST:STUDY_SUMMARY                 	Nicole_Bornkamp@harvardpilgrim.org for questions related to the subject
ST:STUDY_SUMMARY                 	characteristics and outcomes. This research was supported by the Environmental
ST:STUDY_SUMMARY                 	influences on Child Health Outcomes (ECHO) program, Office of The Director,
ST:STUDY_SUMMARY                 	National Institutes of Health. The content is solely the responsibility of the
ST:STUDY_SUMMARY                 	authors and does not necessarily represent the official views of the National
ST:STUDY_SUMMARY                 	Institutes of Health. Project Viva is an ECHO cohort which is supported by the
ST:STUDY_SUMMARY                 	following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical
ST:STUDY_SUMMARY                 	Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C
ST:STUDY_SUMMARY                 	OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of
ST:STUDY_SUMMARY                 	Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute,
ST:STUDY_SUMMARY                 	Durham, North Carolina: Parker CB; U24 OD023382 North Carolina Human Health
ST:STUDY_SUMMARY                 	Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T,
ST:STUDY_SUMMARY                 	University of North Carolina at Chapel Hill: Sumner S, University of North
ST:STUDY_SUMMARY                 	Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis
ST:STUDY_SUMMARY                 	Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B;
ST:STUDY_SUMMARY                 	U24 ES026539
ST:INSTITUTE                     	Harvard Pilgrim Health Care Institute
ST:DEPARTMENT                    	Population Medicine
ST:LABORATORY                    	Channing
ST:LAST_NAME                     	Oken
ST:FIRST_NAME                    	Emily
ST:ADDRESS                       	401 Park Drive Ste 401, Boston, MA 02215
ST:EMAIL                         	emily_oken@harvardpilgrim.org
ST:PHONE                         	617-867-4835
ST:SUBMIT_DATE                   	2021-12-23
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Male and female
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_10_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_10_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_11_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_11_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_12_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_12_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_13_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_13_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_14_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_14_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_15_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_15_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_16_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_16_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_17_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_17_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_18_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_18_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_19_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_19_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_1_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_1_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_20_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_20_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_2_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_2_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_3_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_3_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_4_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_4_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_5_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_5_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_6_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_6_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_7_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_7_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_8_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_8_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	HHEAR_9_Oken	Study type:HHEAR reference material	RAW_FILE_NAME=HHEAR_9_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	NIST_1_Oken	Study type:NIST reference material	RAW_FILE_NAME=NIST_1_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	NIST_2_Oken	Study type:NIST reference material	RAW_FILE_NAME=NIST_2_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	NIST_3_Oken	Study type:NIST reference material	RAW_FILE_NAME=NIST_3_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	NIST_4_Oken	Study type:NIST reference material	RAW_FILE_NAME=NIST_4_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	NIST_5_Oken	Study type:NIST reference material	RAW_FILE_NAME=NIST_5_Oken
SUBJECT_SAMPLE_FACTORS           	N/A	NIST_6_Oken	Study type:NIST reference material	RAW_FILE_NAME=NIST_6_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP99-CBP-01-12701	S_100_Oken	Study type:Study sample	RAW_FILE_NAME=S_100_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNM7-CBP-01-12701	S_101_Oken	Study type:Study sample	RAW_FILE_NAME=S_101_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSB6-CBP-01-12701	S_102_Oken	Study type:Study sample	RAW_FILE_NAME=S_102_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSJ8-CBP-01-12701	S_103_Oken	Study type:Study sample	RAW_FILE_NAME=S_103_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPB9-CBP-01-12701	S_104_Oken	Study type:Study sample	RAW_FILE_NAME=S_104_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTJ7-CBP-01-12701	S_105_Oken	Study type:Study sample	RAW_FILE_NAME=S_105_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT38-CBP-01-12701	S_106_Oken	Study type:Study sample	RAW_FILE_NAME=S_106_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS05-CBP-01-12701	S_107_Oken	Study type:Study sample	RAW_FILE_NAME=S_107_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSS8-CBP-01-12701	S_108_Oken	Study type:Study sample	RAW_FILE_NAME=S_108_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT53-CBP-01-12701	S_109_Oken	Study type:Study sample	RAW_FILE_NAME=S_109_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSE9-CBP-01-12701	S_10_Oken	Study type:Study sample	RAW_FILE_NAME=S_10_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP32-CBP-01-12701	S_110_Oken	Study type:Study sample	RAW_FILE_NAME=S_110_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSA8-CBP-01-12701	S_111_Oken	Study type:Study sample	RAW_FILE_NAME=S_111_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTS7-CBP-01-12701	S_112_Oken	Study type:Study sample	RAW_FILE_NAME=S_112_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRY6-CBP-01-12701	S_113_Oken	Study type:Study sample	RAW_FILE_NAME=S_113_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNB1-CBP-01-12701	S_114_Oken	Study type:Study sample	RAW_FILE_NAME=S_114_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRU5-CBP-01-12701	S_115_Oken	Study type:Study sample	RAW_FILE_NAME=S_115_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTF6-CBP-01-12701	S_116_Oken	Study type:Study sample	RAW_FILE_NAME=S_116_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNK1-CBP-01-12701	S_117_Oken	Study type:Study sample	RAW_FILE_NAME=S_117_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRE0-CBP-01-12701	S_118_Oken	Study type:Study sample	RAW_FILE_NAME=S_118_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQF9-CBP-01-12701	S_119_Oken	Study type:Study sample	RAW_FILE_NAME=S_119_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR14-CBP-01-12701	S_11_Oken	Study type:Study sample	RAW_FILE_NAME=S_11_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS70-CBP-01-12701	S_120_Oken	Study type:Study sample	RAW_FILE_NAME=S_120_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRL5-CBP-01-12701	S_121_Oken	Study type:Study sample	RAW_FILE_NAME=S_121_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSV2-CBP-01-12701	S_122_Oken	Study type:Study sample	RAW_FILE_NAME=S_122_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRX8-CBP-01-12701	S_123_Oken	Study type:Study sample	RAW_FILE_NAME=S_123_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQX9-CBP-01-12701	S_124_Oken	Study type:Study sample	RAW_FILE_NAME=S_124_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQG7-CBP-01-12701	S_125_Oken	Study type:Study sample	RAW_FILE_NAME=S_125_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMQ9-CBP-01-12701	S_126_Oken	Study type:Study sample	RAW_FILE_NAME=S_126_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQY7-CBP-01-12701	S_127_Oken	Study type:Study sample	RAW_FILE_NAME=S_127_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNR6-CBP-01-12701	S_128_Oken	Study type:Study sample	RAW_FILE_NAME=S_128_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPQ6-CBP-01-12701	S_129_Oken	Study type:Study sample	RAW_FILE_NAME=S_129_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMK2-CBP-01-12701	S_12_Oken	Study type:Study sample	RAW_FILE_NAME=S_12_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMR7-CBP-01-12701	S_130_Oken	Study type:Study sample	RAW_FILE_NAME=S_130_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRF8-CBP-01-12701	S_131_Oken	Study type:Study sample	RAW_FILE_NAME=S_131_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMU0-CBP-01-12701	S_132_Oken	Study type:Study sample	RAW_FILE_NAME=S_132_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQN1-CBP-01-12701	S_133_Oken	Study type:Study sample	RAW_FILE_NAME=S_133_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR30-CBP-01-12701	S_134_Oken	Study type:Study sample	RAW_FILE_NAME=S_134_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRC5-CBP-01-12701	S_135_Oken	Study type:Study sample	RAW_FILE_NAME=S_135_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNJ3-CBP-01-12701	S_136_Oken	Study type:Study sample	RAW_FILE_NAME=S_136_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPT9-CBP-01-12701	S_137_Oken	Study type:Study sample	RAW_FILE_NAME=S_137_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMM8-CBP-01-12701	S_138_Oken	Study type:Study sample	RAW_FILE_NAME=S_138_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FU03-CBP-01-12701	S_139_Oken	Study type:Study sample	RAW_FILE_NAME=S_139_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRN0-CBP-01-12701	S_13_Oken	Study type:Study sample	RAW_FILE_NAME=S_13_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPP8-CBP-01-12701	S_140_Oken	Study type:Study sample	RAW_FILE_NAME=S_140_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPH6-CBP-01-12701	S_141_Oken	Study type:Study sample	RAW_FILE_NAME=S_141_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSH3-CBP-01-12701	S_142_Oken	Study type:Study sample	RAW_FILE_NAME=S_142_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRR2-CBP-01-12701	S_143_Oken	Study type:Study sample	RAW_FILE_NAME=S_143_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQT8-CBP-01-12701	S_144_Oken	Study type:Study sample	RAW_FILE_NAME=S_144_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPK9-CBP-01-12701	S_145_Oken	Study type:Study sample	RAW_FILE_NAME=S_145_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP73-CBP-01-12701	S_146_Oken	Study type:Study sample	RAW_FILE_NAME=S_146_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMC0-CBP-01-12701	S_147_Oken	Study type:Study sample	RAW_FILE_NAME=S_147_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNX2-CBP-01-12701	S_148_Oken	Study type:Study sample	RAW_FILE_NAME=S_148_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSQ3-CBP-01-12701	S_149_Oken	Study type:Study sample	RAW_FILE_NAME=S_149_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT04-CBP-01-12701	S_14_Oken	Study type:Study sample	RAW_FILE_NAME=S_14_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTG4-CBP-01-12701	S_150_Oken	Study type:Study sample	RAW_FILE_NAME=S_150_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTQ2-CBP-01-12701	S_151_Oken	Study type:Study sample	RAW_FILE_NAME=S_151_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FM76-CBP-01-12701	S_152_Oken	Study type:Study sample	RAW_FILE_NAME=S_152_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FM68-CBP-01-12701	S_153_Oken	Study type:Study sample	RAW_FILE_NAME=S_153_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ72-CBP-01-12701	S_154_Oken	Study type:Study sample	RAW_FILE_NAME=S_154_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRK7-CBP-01-12701	S_155_Oken	Study type:Study sample	RAW_FILE_NAME=S_155_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPY8-CBP-01-12701	S_156_Oken	Study type:Study sample	RAW_FILE_NAME=S_156_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPC7-CBP-01-12701	S_157_Oken	Study type:Study sample	RAW_FILE_NAME=S_157_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FST6-CBP-01-12701	S_158_Oken	Study type:Study sample	RAW_FILE_NAME=S_158_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FU11-CBP-01-12701	S_159_Oken	Study type:Study sample	RAW_FILE_NAME=S_159_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMB2-CBP-01-12701	S_15_Oken	Study type:Study sample	RAW_FILE_NAME=S_15_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQB8-CBP-01-12701	S_160_Oken	Study type:Study sample	RAW_FILE_NAME=S_160_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN34-CBP-01-12701	S_161_Oken	Study type:Study sample	RAW_FILE_NAME=S_161_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP24-CBP-01-12701	S_162_Oken	Study type:Study sample	RAW_FILE_NAME=S_162_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT95-CBP-01-12701	S_163_Oken	Study type:Study sample	RAW_FILE_NAME=S_163_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS39-CBP-01-12701	S_164_Oken	Study type:Study sample	RAW_FILE_NAME=S_164_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ07-CBP-01-12701	S_165_Oken	Study type:Study sample	RAW_FILE_NAME=S_165_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPR4-CBP-01-12701	S_166_Oken	Study type:Study sample	RAW_FILE_NAME=S_166_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTC3-CBP-01-12701	S_167_Oken	Study type:Study sample	RAW_FILE_NAME=S_167_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSF7-CBP-01-12701	S_168_Oken	Study type:Study sample	RAW_FILE_NAME=S_168_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNF2-CBP-01-12701	S_169_Oken	Study type:Study sample	RAW_FILE_NAME=S_169_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMJ4-CBP-01-12701	S_16_Oken	Study type:Study sample	RAW_FILE_NAME=S_16_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQH5-CBP-01-12701	S_170_Oken	Study type:Study sample	RAW_FILE_NAME=S_170_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPA1-CBP-01-12701	S_171_Oken	Study type:Study sample	RAW_FILE_NAME=S_171_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNY0-CBP-01-12701	S_172_Oken	Study type:Study sample	RAW_FILE_NAME=S_172_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRB7-CBP-01-12701	S_173_Oken	Study type:Study sample	RAW_FILE_NAME=S_173_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN91-CBP-01-12701	S_174_Oken	Study type:Study sample	RAW_FILE_NAME=S_174_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQE1-CBP-01-12701	S_175_Oken	Study type:Study sample	RAW_FILE_NAME=S_175_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR97-CBP-01-12701	S_176_Oken	Study type:Study sample	RAW_FILE_NAME=S_176_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRT7-CBP-01-12701	S_177_Oken	Study type:Study sample	RAW_FILE_NAME=S_177_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPG8-CBP-01-12701	S_178_Oken	Study type:Study sample	RAW_FILE_NAME=S_178_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMH9-CBP-01-12701	S_179_Oken	Study type:Study sample	RAW_FILE_NAME=S_179_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNP0-CBP-01-12701	S_17_Oken	Study type:Study sample	RAW_FILE_NAME=S_17_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS96-CBP-01-12701	S_180_Oken	Study type:Study sample	RAW_FILE_NAME=S_180_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQS0-CBP-01-12701	S_181_Oken	Study type:Study sample	RAW_FILE_NAME=S_181_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPV5-CBP-01-12701	S_182_Oken	Study type:Study sample	RAW_FILE_NAME=S_182_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN75-CBP-01-12701	S_183_Oken	Study type:Study sample	RAW_FILE_NAME=S_183_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMD7-CBP-01-12701	S_184_Oken	Study type:Study sample	RAW_FILE_NAME=S_184_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTU3-CBP-01-12701	S_185_Oken	Study type:Study sample	RAW_FILE_NAME=S_185_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS88-CBP-01-12701	S_186_Oken	Study type:Study sample	RAW_FILE_NAME=S_186_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP57-CBP-01-12701	S_187_Oken	Study type:Study sample	RAW_FILE_NAME=S_187_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSX7-CBP-01-12701	S_188_Oken	Study type:Study sample	RAW_FILE_NAME=S_188_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQA0-CBP-01-12701	S_18_Oken	Study type:Study sample	RAW_FILE_NAME=S_18_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FM84-CBP-01-12701	S_19_Oken	Study type:Study sample	RAW_FILE_NAME=S_19_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSM2-CBP-01-12701	S_1_Oken	Study type:Study sample	RAW_FILE_NAME=S_1_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMS4-CBP-01-12701	S_20_Oken	Study type:Study sample	RAW_FILE_NAME=S_20_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMT2-CBP-01-12701	S_21_Oken	Study type:Study sample	RAW_FILE_NAME=S_21_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMW6-CBP-01-12701	S_22_Oken	Study type:Study sample	RAW_FILE_NAME=S_22_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPU7-CBP-01-12701	S_23_Oken	Study type:Study sample	RAW_FILE_NAME=S_23_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRM3-CBP-01-12701	S_24_Oken	Study type:Study sample	RAW_FILE_NAME=S_24_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN67-CBP-01-12701	S_25_Oken	Study type:Study sample	RAW_FILE_NAME=S_25_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNC9-CBP-01-12701	S_26_Oken	Study type:Study sample	RAW_FILE_NAME=S_26_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP08-CBP-01-12701	S_27_Oken	Study type:Study sample	RAW_FILE_NAME=S_27_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ23-CBP-01-12701	S_28_Oken	Study type:Study sample	RAW_FILE_NAME=S_28_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT87-CBP-01-12701	S_29_Oken	Study type:Study sample	RAW_FILE_NAME=S_29_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FM92-CBP-01-12701	S_2_Oken	Study type:Study sample	RAW_FILE_NAME=S_2_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQD3-CBP-01-12701	S_30_Oken	Study type:Study sample	RAW_FILE_NAME=S_30_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQC6-CBP-01-12701	S_31_Oken	Study type:Study sample	RAW_FILE_NAME=S_31_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTH2-CBP-01-12701	S_32_Oken	Study type:Study sample	RAW_FILE_NAME=S_32_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMP1-CBP-01-12701	S_33_Oken	Study type:Study sample	RAW_FILE_NAME=S_33_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNS3-CBP-01-12701	S_34_Oken	Study type:Study sample	RAW_FILE_NAME=S_34_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTY4-CBP-01-12701	S_35_Oken	Study type:Study sample	RAW_FILE_NAME=S_35_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP65-CBP-01-12701	S_36_Oken	Study type:Study sample	RAW_FILE_NAME=S_36_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQV4-CBP-01-12701	S_37_Oken	Study type:Study sample	RAW_FILE_NAME=S_37_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ31-CBP-01-12701	S_38_Oken	Study type:Study sample	RAW_FILE_NAME=S_38_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMN5-CBP-01-12701	S_39_Oken	Study type:Study sample	RAW_FILE_NAME=S_39_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPJ1-CBP-01-12701	S_3_Oken	Study type:Study sample	RAW_FILE_NAME=S_3_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRW1-CBP-01-12701	S_40_Oken	Study type:Study sample	RAW_FILE_NAME=S_40_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQK8-CBP-01-12701	S_41_Oken	Study type:Study sample	RAW_FILE_NAME=S_41_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPF0-CBP-01-12701	S_42_Oken	Study type:Study sample	RAW_FILE_NAME=S_42_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS54-CBP-01-12701	S_43_Oken	Study type:Study sample	RAW_FILE_NAME=S_43_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN59-CBP-01-12701	S_44_Oken	Study type:Study sample	RAW_FILE_NAME=S_44_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNG0-CBP-01-12701	S_45_Oken	Study type:Study sample	RAW_FILE_NAME=S_45_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSG5-CBP-01-12701	S_46_Oken	Study type:Study sample	RAW_FILE_NAME=S_46_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTA7-CBP-01-12701	S_47_Oken	Study type:Study sample	RAW_FILE_NAME=S_47_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ49-CBP-01-12701	S_48_Oken	Study type:Study sample	RAW_FILE_NAME=S_48_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ15-CBP-01-12701	S_49_Oken	Study type:Study sample	RAW_FILE_NAME=S_49_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR22-CBP-01-12701	S_4_Oken	Study type:Study sample	RAW_FILE_NAME=S_4_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNA3-CBP-01-12701	S_50_Oken	Study type:Study sample	RAW_FILE_NAME=S_50_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FND6-CBP-01-12701	S_51_Oken	Study type:Study sample	RAW_FILE_NAME=S_51_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR48-CBP-01-12701	S_52_Oken	Study type:Study sample	RAW_FILE_NAME=S_52_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPL7-CBP-01-12701	S_53_Oken	Study type:Study sample	RAW_FILE_NAME=S_53_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMV8-CBP-01-12701	S_54_Oken	Study type:Study sample	RAW_FILE_NAME=S_54_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTK5-CBP-01-12701	S_55_Oken	Study type:Study sample	RAW_FILE_NAME=S_55_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FP81-CBP-01-12701	S_56_Oken	Study type:Study sample	RAW_FILE_NAME=S_56_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPX0-CBP-01-12701	S_57_Oken	Study type:Study sample	RAW_FILE_NAME=S_57_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMF3-CBP-01-12701	S_58_Oken	Study type:Study sample	RAW_FILE_NAME=S_58_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ64-CBP-01-12701	S_59_Oken	Study type:Study sample	RAW_FILE_NAME=S_59_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTP4-CBP-01-12701	S_5_Oken	Study type:Study sample	RAW_FILE_NAME=S_5_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTE8-CBP-01-12701	S_60_Oken	Study type:Study sample	RAW_FILE_NAME=S_60_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRS9-CBP-01-12701	S_61_Oken	Study type:Study sample	RAW_FILE_NAME=S_61_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQJ0-CBP-01-12701	S_62_Oken	Study type:Study sample	RAW_FILE_NAME=S_62_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT61-CBP-01-12701	S_63_Oken	Study type:Study sample	RAW_FILE_NAME=S_63_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FpS1-CBP-01-12701	S_64_Oken	Study type:Study sample	RAW_FILE_NAME=S_64_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNQ8-CBP-01-12701	S_65_Oken	Study type:Study sample	RAW_FILE_NAME=S_65_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FML0-CBP-01-12701	S_66_Oken	Study type:Study sample	RAW_FILE_NAME=S_66_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTW9-CBP-01-12701	S_67_Oken	Study type:Study sample	RAW_FILE_NAME=S_67_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTD0-CBP-01-12701	S_68_Oken	Study type:Study sample	RAW_FILE_NAME=S_68_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTT5-CBP-01-12701	S_69_Oken	Study type:Study sample	RAW_FILE_NAME=S_69_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ80-CBP-01-12701	S_6_Oken	Study type:Study sample	RAW_FILE_NAME=S_6_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSY5-CBP-01-12701	S_70_Oken	Study type:Study sample	RAW_FILE_NAME=S_70_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS62-CBP-01-12701	S_71_Oken	Study type:Study sample	RAW_FILE_NAME=S_71_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ56-CBP-01-12701	S_72_Oken	Study type:Study sample	RAW_FILE_NAME=S_72_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNT1-CBP-01-12701	S_73_Oken	Study type:Study sample	RAW_FILE_NAME=S_73_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNN4-CBP-01-12701	S_74_Oken	Study type:Study sample	RAW_FILE_NAME=S_74_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPD4-CBP-01-12701	S_75_Oken	Study type:Study sample	RAW_FILE_NAME=S_75_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPN2-CBP-01-12701	S_76_Oken	Study type:Study sample	RAW_FILE_NAME=S_76_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRQ4-CBP-01-12701	S_77_Oken	Study type:Study sample	RAW_FILE_NAME=S_77_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTX6-CBP-01-12701	S_78_Oken	Study type:Study sample	RAW_FILE_NAME=S_78_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRP6-CBP-01-12701	S_79_Oken	Study type:Study sample	RAW_FILE_NAME=S_79_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRV3-CBP-01-12701	S_7_Oken	Study type:Study sample	RAW_FILE_NAME=S_7_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTB5-CBP-01-12701	S_80_Oken	Study type:Study sample	RAW_FILE_NAME=S_80_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNU9-CBP-01-12701	S_81_Oken	Study type:Study sample	RAW_FILE_NAME=S_81_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQR3-CBP-01-12701	S_82_Oken	Study type:Study sample	RAW_FILE_NAME=S_82_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRG6-CBP-01-12701	S_83_Oken	Study type:Study sample	RAW_FILE_NAME=S_83_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQ98-CBP-01-12701	S_84_Oken	Study type:Study sample	RAW_FILE_NAME=S_84_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR89-CBP-01-12701	S_85_Oken	Study type:Study sample	RAW_FILE_NAME=S_85_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPW3-CBP-01-12701	S_86_Oken	Study type:Study sample	RAW_FILE_NAME=S_86_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQQ5-CBP-01-12701	S_87_Oken	Study type:Study sample	RAW_FILE_NAME=S_87_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN83-CBP-01-12701	S_88_Oken	Study type:Study sample	RAW_FILE_NAME=S_88_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMG1-CBP-01-12701	S_89_Oken	Study type:Study sample	RAW_FILE_NAME=S_89_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSK6-CBP-01-12701	S_8_Oken	Study type:Study sample	RAW_FILE_NAME=S_8_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN00-CBP-01-12701	S_90_Oken	Study type:Study sample	RAW_FILE_NAME=S_90_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNH8-CBP-01-12701	S_91_Oken	Study type:Study sample	RAW_FILE_NAME=S_91_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRA9-CBP-01-12701	S_92_Oken	Study type:Study sample	RAW_FILE_NAME=S_92_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRD2-CBP-01-12701	S_93_Oken	Study type:Study sample	RAW_FILE_NAME=S_93_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNE4-CBP-01-12701	S_94_Oken	Study type:Study sample	RAW_FILE_NAME=S_94_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT46-CBP-01-12701	S_95_Oken	Study type:Study sample	RAW_FILE_NAME=S_95_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPE2-CBP-01-12701	S_96_Oken	Study type:Study sample	RAW_FILE_NAME=S_96_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR71-CBP-01-12701	S_97_Oken	Study type:Study sample	RAW_FILE_NAME=S_97_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FPM5-CBP-01-12701	S_98_Oken	Study type:Study sample	RAW_FILE_NAME=S_98_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSL4-CBP-01-12701	S_99_Oken	Study type:Study sample	RAW_FILE_NAME=S_99_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT79-CBP-01-12701	S_9_Oken	Study type:Study sample	RAW_FILE_NAME=S_9_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMY1-QCSP-10-12701	SP_10_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_10_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN42-QCSP-11-12701	SP_11_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_11_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS13-QCSP-12-12701	SP_12_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_12_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FT20-QCSP-13-12701	SP_13_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_13_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR55-QCSP-14-12701	SP_14_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_14_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSR1-QCSP-15-12701	SP_15_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_15_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FTM1-QCSP-16-12701	SP_16_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_16_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSC4-QCSP-17-12701	SP_17_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_17_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FMA4-QCSP-18-12701	SP_18_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_18_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FME5-QCSP-19-12701	SP_19_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_19_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQL6-QCSP-01-12701	SP_1_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_1_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FQM4-QCSP-20-12701	SP_20_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_20_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSN9-QCSP-02-12701	SP_2_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_2_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FNL9-QCSP-03-12701	SP_3_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_3_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSD1-QCSP-04-12701	SP_4_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_4_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FR06-QCSP-05-12701	SP_5_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_5_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FS47-QCSP-06-12701	SP_6_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_6_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FSU4-QCSP-07-12701	SP_7_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_7_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FRH4-QCSP-08-12701	SP_8_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_8_Oken
SUBJECT_SAMPLE_FACTORS           	EM-2FN18-QCSP-09-12701	SP_9_Oken	Study type:Total Study Pool	RAW_FILE_NAME=SP_9_Oken
#COLLECTION
CO:COLLECTION_SUMMARY            	Pregnant women were enrolled in Project Viva between 1999 and 2002 at their
CO:COLLECTION_SUMMARY            	first prenatal visit at one of 8 obstetric clinics of Atrius Harvard Vanguard
CO:COLLECTION_SUMMARY            	Medical Associates, a multispecialty group practice in eastern Massachusetts.
CO:COLLECTION_SUMMARY            	Eligible mothers were fluent in English, had singleton gestations, were <22
CO:COLLECTION_SUMMARY            	weeks gestation, and had no plans to move away from the study area. Research
CO:COLLECTION_SUMMARY            	staff performed in-person study visits with participating mothers in the first
CO:COLLECTION_SUMMARY            	(median gestational age 9.9 weeks) and second (median gestational age 28.1
CO:COLLECTION_SUMMARY            	weeks) trimesters of pregnancy, and with mothers and children during the first
CO:COLLECTION_SUMMARY            	few days after delivery, during infancy (median age 6.3 months), in early
CO:COLLECTION_SUMMARY            	childhood (median age 3.3 years), mid-childhood (median age 7.7 years), and
CO:COLLECTION_SUMMARY            	adolescence (median age13 years).
CO:SAMPLE_TYPE                   	Blood (plasma)
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	N/A
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Study plasma samples (50 µL) and total study pool samples (50 µL) were
SP:SAMPLEPREP_SUMMARY            	prepared and shipped from the Channing Laboratory Division of Network Medicine
SP:SAMPLEPREP_SUMMARY            	at Brigham and Women’s Hospital, Boston, MA, to the NC HHEAR Hub on dry ice.
SP:SAMPLEPREP_SUMMARY            	Aliquots of HHEAR reference plasma (50 µL each) and NIST plasma (1950)
SP:SAMPLEPREP_SUMMARY            	reference material (50 µL each) were provided by the NC HHEAR Hub. All samples
SP:SAMPLEPREP_SUMMARY            	were stored under -80° C until lab analysis. All samples were thawed at 4 °C
SP:SAMPLEPREP_SUMMARY            	overnight a day before sample preparation. The same volume (50 µL) of LC-MS
SP:SAMPLEPREP_SUMMARY            	grade water was used as blank. Samples, including study samples, total study
SP:SAMPLEPREP_SUMMARY            	pool samples, HHEAR reference material, NIST reference material, and blanks were
SP:SAMPLEPREP_SUMMARY            	mixed with 400 µL methanol containing 500 ng/mL tryptophan-d5 as internal
SP:SAMPLEPREP_SUMMARY            	standard and vortexed by the multiple tube vortex mixer for 2 min at 5000 rpm in
SP:SAMPLEPREP_SUMMARY            	room temperature. All samples were centrifuged at 16,000 rcf for 10 min at 4°C.
SP:SAMPLEPREP_SUMMARY            	The supernatant (350 µL) was transferred into a pre-labeled 2.0 mL Lo-bind
SP:SAMPLEPREP_SUMMARY            	Eppendorf tube, and then dried by a SpeedVac overnight. For immediate analysis,
SP:SAMPLEPREP_SUMMARY            	100 µL of water-methanol solution (95:5, v/v) was used to reconstitute the
SP:SAMPLEPREP_SUMMARY            	dried extracts, and the samples were thoroughly mixed on the multiple tube
SP:SAMPLEPREP_SUMMARY            	vortex mixer for 10 min at 5000 rpm in room temperature. All samples were
SP:SAMPLEPREP_SUMMARY            	centrifuged at 4°C for 10 min at 16,000 rcf. The supernatant was transferred to
SP:SAMPLEPREP_SUMMARY            	pre-labeled autosampler vials for data acquisition by LC-MS.
SP:PROCESSING_STORAGE_CONDITIONS 	On ice
SP:EXTRACT_STORAGE               	Described in summary
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Reverse phase
CH:INSTRUMENT_NAME               	Thermo Scientific™ Vanquish™ UPHPLC
CH:COLUMN_NAME                   	Waters ACQUITY UPLC HSS T3 (100 x 2.1mm,3um)
CH:COLUMN_PRESSURE               	6000-10000
CH:COLUMN_TEMPERATURE            	50
CH:FLOW_GRADIENT                 	Time(min) Flow Rate %A %B Curve 1. 0 0.4 99.0 1.0 5 2. 1.00 0.4 99.0 1.0 5 3.
CH:FLOW_GRADIENT                 	16.00 0.4 1.0 99.0 5 4. 19.00 0.4 1.0 99.0 5 5. 19.50 0.4 99.0 1.0 5 6. 22.00
CH:FLOW_GRADIENT                 	0.4 99.0 1.0 5
CH:FLOW_RATE                     	0.4 ml/min
CH:INJECTION_TEMPERATURE         	8
CH:SOLVENT_A                     	100% water; 0.1% formic acid
CH:SOLVENT_B                     	100% methanol; 0.1% formic acid
CH:RANDOMIZATION_ORDER           	Randomized
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive HF hybrid Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:MS_COMMENTS                   	Instrument: Thermo Q Exactive HFx Software: Xcalibur 4.1.31.9 for data
MS:MS_COMMENTS                   	acquisition; Progenesis QI 2.1 for data preprocessing
MS:ION_MODE                      	POSITIVE
MS:CAPILLARY_TEMPERATURE         	320 °C
MS:CAPILLARY_VOLTAGE             	3.5 KV
MS:COLLISION_ENERGY              	20-45, ramp
MS:COLLISION_GAS                 	N2
MS:DRY_GAS_FLOW                  	55
MS:DRY_GAS_TEMP                  	400°C
MS:FRAGMENTATION_METHOD          	CID
MS:DESOLVATION_GAS_FLOW          	55
MS:MS_RESULTS_FILE               	ST002050_AN003337_Results.txt	UNITS:Normalized intensity	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END