#METABOLOMICS WORKBENCH Madjihounoum_20221203_061829 DATATRACK_ID:3623 STUDY_ID:ST002435 ANALYSIS_ID:AN003967 PROJECT_ID:PR001567 VERSION 1 CREATED_ON January 11, 2023, 1:34 pm #PROJECT PR:PROJECT_TITLE Multiomics study of CHCHD10S59L-related disease reveals energy metabolism PR:PROJECT_TITLE downregulation: OXPHOS and β-oxidation deficiencies associated with lipids PR:PROJECT_TITLE alterations PR:PROJECT_SUMMARY Mutations in the coiled-coil-helix-coiled-coil-helix domain containing 10 PR:PROJECT_SUMMARY (CHCHD10) gene have been associated with a large clinical spectrum including PR:PROJECT_SUMMARY myopathy, cardiomyopathy and amyotrophic lateral sclerosis (ALS). Herein, we PR:PROJECT_SUMMARY analyzed the metabolic changes induced by the p.S59L CHCHD10 mutation to PR:PROJECT_SUMMARY identify new therapeutic opportunities. Using metabolomic, lipidomic and PR:PROJECT_SUMMARY proteomic analysis we observed a strong alteration of metabolism in plasma and PR:PROJECT_SUMMARY heart of Chchd10S59L/+ mice compared to their wild type littermates at PR:PROJECT_SUMMARY pre-symptomatic and symptomatic stages. In plasma, levels of phospholipids were PR:PROJECT_SUMMARY decreased while those of carnitine derivatives and most of amino acids were PR:PROJECT_SUMMARY increased. The cardiac tissue from Chchd10S59L/+ mice showed a decreased PR:PROJECT_SUMMARY Oxidative Phosphorylation (OXPHOS) and β-oxidation proteins levels as well as PR:PROJECT_SUMMARY tricarboxylic acid cycle (TCA) intermediates and carnitine pathway metabolism. PR:PROJECT_SUMMARY In parallel, lipidomics analysis reveals a drastic change in the lipidome, PR:PROJECT_SUMMARY including triglyceride, cardiolipin and phospholipids. Consistent with this PR:PROJECT_SUMMARY energetic deficiency in cardiac tissue, we show that L-acetylcarnitine PR:PROJECT_SUMMARY supplementation improves the mitochondrial network length in IPS-derived PR:PROJECT_SUMMARY cardiomyocytes from a patient carrying the CHCHD10S59L/+ mutation. These data PR:PROJECT_SUMMARY indicate that a bioenergetic intermediate such as L-acetylcarnitine may restore PR:PROJECT_SUMMARY mitochondrial function in CHCHD10-related disease, due to the reduction in PR:PROJECT_SUMMARY energy deficit that could be compensated by carnitine metabolic pathways. PR:INSTITUTE INSERM PR:LAST_NAME Madji Hounoum PR:FIRST_NAME Blandine PR:ADDRESS 151 Route Saint Antoine de Genistière 06204 Nice PR:EMAIL madjihounoum@yahoo.fr PR:PHONE +33 (0)4 89 06 43 01 #STUDY ST:STUDY_TITLE Metabolomics analysis of plasma from CHCHD10S59L/+ KI mice ST:STUDY_SUMMARY Mutations in the coiled-coil-helix-coiled-coil-helix domain containing 10 ST:STUDY_SUMMARY (CHCHD10) gene have been associated with a large clinical spectrum including ST:STUDY_SUMMARY myopathy, cardiomyopathy and amyotrophic lateral sclerosis (ALS). Herein, we ST:STUDY_SUMMARY analyzed the metabolic changes induced by the p.S59L CHCHD10 mutation to ST:STUDY_SUMMARY identify new therapeutic opportunities. Using metabolomic, lipidomic and ST:STUDY_SUMMARY proteomic analysis we observed a strong alteration of metabolism in plasma and ST:STUDY_SUMMARY heart of Chchd10S59L/+ mice compared to their wild type littermates at ST:STUDY_SUMMARY pre-symptomatic and symptomatic stages. In plasma, levels of phospholipids were ST:STUDY_SUMMARY decreased while those of carnitine derivatives and most of amino acids were ST:STUDY_SUMMARY increased. The cardiac tissue from Chchd10S59L/+ mice showed a decreased ST:STUDY_SUMMARY Oxidative Phosphorylation (OXPHOS) and β-oxidation proteins levels as well as ST:STUDY_SUMMARY tricarboxylic acid cycle (TCA) intermediates and carnitine pathway metabolism. ST:STUDY_SUMMARY In parallel, lipidomics analysis reveals a drastic change in the lipidome, ST:STUDY_SUMMARY including triglyceride, cardiolipin and phospholipids. Consistent with this ST:STUDY_SUMMARY energetic deficiency in cardiac tissue, we show that L-acetylcarnitine ST:STUDY_SUMMARY supplementation improves the mitochondrial network length in IPS-derived ST:STUDY_SUMMARY cardiomyocytes from a patient carrying the CHCHD10S59L/+ mutation. These data ST:STUDY_SUMMARY indicate that a bioenergetic intermediate such as L-acetylcarnitine may restore ST:STUDY_SUMMARY mitochondrial function in CHCHD10-related disease, due to the reduction in ST:STUDY_SUMMARY energy deficit that could be compensated by carnitine metabolic pathways. ST:INSTITUTE INSERM ST:LAST_NAME Madji Hounoum ST:FIRST_NAME Blandine ST:ADDRESS 151 Route Saint Antoine de Genistière 06204 Nice ST:EMAIL madjihounoum@yahoo.fr ST:PHONE +33 (0)4 89 06 43 01 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - Plasma_2014 Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2014.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2015 Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2015.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2024 Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2024.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2027 Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2027.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2012 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2012.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2016 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2016.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2017 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2017.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2025 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2025.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2800 Genotype:Wild-type | Gender:Male | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2800.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2801 Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Pre-symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2801.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2772 Genotype:Wild-type | Gender:female | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2772.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2773 Genotype:Wild-type | Gender:female | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2773.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2768 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2768.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2769 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2769.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2008 Genotype:Wild-type | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2008.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2018 Genotype:Wild-type | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2018.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2019 Genotype:Wild-type | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2019.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2020 Genotype:Wild-type | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2020.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2007 Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2007.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2009 Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2009.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2010 Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2010.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_2021 Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_2021.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_1674 Genotype:Wild-type | Gender:female | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_1674.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_1675 Genotype:CHCHD10S59L/+ | Gender:female | Stage:Symptomatic RAW_FILE_NAME=C18_Neg_Plasma_1675.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_QC1 Genotype:QC | Gender:QC | Stage:QC RAW_FILE_NAME=C18_Neg_Plasma_QC1.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_QC2 Genotype:QC | Gender:QC | Stage:QC RAW_FILE_NAME=C18_Neg_Plasma_QC2.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_QC3 Genotype:QC | Gender:QC | Stage:QC RAW_FILE_NAME=C18_Neg_Plasma_QC3.mzXML SUBJECT_SAMPLE_FACTORS - Plasma_QC4 Genotype:QC | Gender:QC | Stage:QC RAW_FILE_NAME=C18_Neg_Plasma_QC4.mzXML #COLLECTION CO:COLLECTION_SUMMARY Blood was taken by cardiac puncture from mice at pre-symptomatic (16 to 20 weeks CO:COLLECTION_SUMMARY of ages, n=5 mice per group) and symptomatic (40 to 48 weeks of ages, n=7 mice CO:COLLECTION_SUMMARY per group) stages, and transferred to EDTA coated tubes (Sarstedt). Then, blood CO:COLLECTION_SUMMARY was centrifuged at 500 rpm for 10 min at 4°C, plasma was collected and CO:COLLECTION_SUMMARY immediately frozen in microtubes (Eppendorf) and stored at −80°C until CO:COLLECTION_SUMMARY further analyses CO:SAMPLE_TYPE Blood (plasma) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Then, blood was centrifuged at 500 rpm for 10 min at 4°C, plasma was collected TR:TREATMENT_SUMMARY and immediately frozen in microtubes (Eppendorf) and stored at −80°C until TR:TREATMENT_SUMMARY further analyses #SAMPLEPREP SP:SAMPLEPREP_SUMMARY 20 µL were precipitated with methanol and centrifuged at 16 000 x g for 10 mins SP:SAMPLEPREP_SUMMARY at 4°C, and the supernatant was dried SP:PROCESSING_STORAGE_CONDITIONS 4℃ SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Phenomenex Kinetex HILIC 100A (50 x 2.1 mm, 2.6um) CH:SOLVENT_A Water CH:SOLVENT_B Methanol CH:FLOW_GRADIENT 20 minutes CH:FLOW_RATE 0.4 mL/min CH:COLUMN_TEMPERATURE 55°C #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS The full-scan acquisition ranged from 58 to 870 m/z, the instrument operated at MS:MS_COMMENTS 70,000 resolution (m/z = 200).A targeted analysis was applied on the samples, MS:MS_COMMENTS based on a library of standard compounds (Mass Spectroscopy Metabolite Library MS:MS_COMMENTS (MSML®) of standards, IROA Technologies™). The following criteria were MS:MS_COMMENTS followed to identify the metabolites: (1) retention time of the detected MS:MS_COMMENTS metabolite within ± 20 s of the standard reference, (2) exact measured of MS:MS_COMMENTS molecular mass of the metabolite within a range of 10 ppm around the known MS:MS_COMMENTS molecular mass of the reference compound, and (3) correspondence between MS:MS_COMMENTS isotopic ratios of the metabolite and the standard reference. The signal value MS:MS_COMMENTS was calculated using Xcalibur® software (Thermo Fisher Scientific, San Jose, MS:MS_COMMENTS CA) by integrating the chromatographic peak area corresponding to the selected MS:MS_COMMENTS metabolite. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Relative units MS_METABOLITE_DATA_START Samples Plasma_2014 Plasma_2015 Plasma_2800 Plasma_2801 Plasma_2020 Plasma_2769 Plasma_2007 Plasma_2009 Plasma_1674 Plasma_2773 Plasma_2012 Plasma_2016 Plasma_1675 Plasma_2772 Plasma_2010 Plasma_2018 Plasma_2025 Plasma_2008 Plasma_2021 Plasma_2019 Plasma_2017 Plasma_2024 Plasma_2027 Plasma_2768 Plasma_QC1 Plasma_QC2 Plasma_QC3 Plasma_QC4 Factors Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic Genotype:Wild-type | Gender:Male | Stage:Pre-symptomatic Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Pre-symptomatic Genotype:Wild-type | Gender:Male | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic Genotype:Wild-type | Gender:female | Stage:Symptomatic Genotype:Wild-type | Gender:female | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Symptomatic Genotype:Wild-type | Gender:female | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic Genotype:Wild-type | Gender:Male | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic Genotype:Wild-type | Gender:Male | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:Male | Stage:Symptomatic Genotype:Wild-type | Gender:Male | Stage:Symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Pre-symptomatic Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic Genotype:Wild-type | Gender:female | Stage:Pre-symptomatic Genotype:CHCHD10S59L/+ | Gender:female | Stage:Symptomatic Genotype:QC | Gender:QC | Stage:QC Genotype:QC | Gender:QC | Stage:QC Genotype:QC | Gender:QC | Stage:QC Genotype:QC | Gender:QC | Stage:QC LPC(16:0) 404E+09 385E+09 552E+09 441E+09 456E+09 441E+09 435E+09 424E+09 297E+09 536E+09 403E+09 272E+09 281E+09 348E+09 320E+09 394E+09 311E+09 454E+09 307E+09 568E+09 335E+09 317E+09 376E+09 396E+09 559E+09 494E+09 518E+09 602E+09 BETAINE 402E+09 546E+09 278E+09 669E+09 279E+09 294E+09 421E+09 494E+09 154E+10 285E+09 845E+09 295E+09 576E+09 229E+09 587E+09 254E+09 482E+09 275E+09 588E+09 347E+09 382E+09 370E+09 909E+09 384E+09 657E+09 601E+09 577E+09 621E+09 LPC(18:0) 207E+09 151E+09 241E+09 162E+09 221E+09 218E+09 169E+09 152E+09 447E+08 273E+09 188E+09 123E+09 108E+09 170E+09 108E+09 189E+09 129E+09 174E+09 120E+09 258E+09 141E+09 140E+09 132E+09 172E+09 243E+09 213E+09 236E+09 278E+09 PC(34:2) 142E+09 241E+09 218E+09 243E+09 259E+09 166E+09 301E+09 279E+09 195E+08 230E+09 165E+09 201E+09 184E+09 117E+09 153E+09 256E+09 197E+09 220E+09 146E+09 333E+09 240E+09 216E+09 104E+09 180E+09 312E+09 279E+09 272E+09 266E+09 L-CARNITINE 142E+09 118E+09 168E+09 658E+09 185E+09 162E+09 214E+09 318E+09 174E+10 197E+09 889E+09 107E+09 574E+09 172E+09 548E+09 190E+09 343E+09 232E+09 316E+09 348E+09 203E+09 310E+09 750E+09 279E+09 543E+09 496E+09 407E+09 476E+09 O-ACETYL-L-CARNITINE 120E+09 992E+08 795E+08 381E+09 111E+09 200E+09 134E+09 263E+09 175E+10 178E+09 570E+09 837E+08 366E+09 126E+09 368E+09 983E+08 205E+09 116E+09 178E+09 121E+09 137E+09 174E+09 451E+09 149E+09 453E+09 355E+09 296E+09 359E+09 PC(36:2) 102E+09 131E+09 149E+09 127E+09 176E+09 121E+09 166E+09 164E+09 103E+08 168E+09 107E+09 125E+09 129E+09 948E+08 805E+08 180E+09 118E+09 138E+09 106E+09 211E+09 142E+09 125E+09 465E+08 133E+09 185E+09 174E+09 170E+09 166E+09 CREATININE 854E+08 962E+08 552E+08 140E+09 759E+08 811E+08 115E+09 129E+09 504E+09 117E+09 262E+09 121E+09 205E+09 803E+08 140E+09 993E+08 184E+09 101E+09 787E+08 108E+09 188E+09 752E+08 226E+09 104E+09 185E+09 186E+09 168E+09 174E+09 PC(34:1) 835E+08 739E+08 176E+09 130E+09 145E+09 115E+09 111E+09 129E+09 924E+07 120E+09 787E+08 794E+08 945E+08 858E+08 774E+08 113E+09 673E+08 124E+09 874E+08 144E+09 835E+08 924E+08 396E+08 123E+09 147E+09 131E+09 129E+09 126E+09 LPC(18:2) 825E+08 126E+09 153E+09 181E+09 143E+09 113E+09 180E+09 173E+09 145E+09 252E+09 200E+09 740E+08 161E+09 689E+08 115E+09 141E+09 121E+09 115E+09 121E+09 228E+09 134E+09 181E+09 112E+09 111E+09 208E+09 179E+09 194E+09 231E+09 LPC(18:1) 813E+08 616E+08 231E+09 140E+09 138E+09 133E+09 119E+09 124E+09 550E+08 186E+09 119E+09 458E+08 107E+09 938E+08 849E+08 111E+09 601E+08 107E+09 858E+08 186E+09 659E+08 882E+08 508E+08 110E+09 165E+09 139E+09 155E+09 190E+09 PC(O-14:0/2:0) 672E+08 534E+08 112E+09 840E+08 811E+08 821E+08 781E+08 806E+08 896E+07 104E+09 700E+08 441E+08 445E+08 634E+08 580E+08 764E+08 565E+08 831E+08 495E+08 121E+09 696E+08 515E+08 590E+08 760E+08 104E+09 923E+08 982E+08 115E+09 CREATINE 551E+08 573E+08 298E+08 142E+09 456E+08 445E+08 787E+08 111E+09 730E+09 310E+08 201E+09 572E+08 200E+09 426E+08 176E+09 445E+08 132E+09 767E+08 915E+08 601E+08 717E+08 675E+08 318E+09 554E+08 135E+09 130E+09 953E+08 956E+08 TAURINE 399E+08 610E+08 306E+08 150E+09 399E+08 395E+08 638E+08 116E+09 845E+09 617E+08 205E+09 475E+08 114E+09 454E+08 147E+09 409E+08 955E+08 430E+08 140E+09 573E+08 793E+08 790E+08 143E+09 665E+08 186E+09 175E+09 131E+09 134E+09 NICOTINAMIDE 369E+08 485E+08 252E+08 199E+08 206E+08 357E+08 218E+08 250E+08 231E+08 339E+08 285E+08 193E+08 249E+08 306E+08 169E+08 259E+08 224E+08 242E+08 778E+08 238E+08 200E+08 176E+08 250E+08 263E+08 352E+08 367E+08 370E+08 373E+08 L-PROLINE 359E+08 723E+08 205E+08 129E+09 330E+08 335E+08 774E+08 114E+09 490E+09 372E+08 220E+09 704E+08 841E+08 292E+08 157E+09 370E+08 182E+09 305E+08 709E+08 561E+08 145E+09 424E+08 268E+09 841E+08 143E+09 124E+09 968E+08 110E+09 GAMMA-LINOLENIC_ACID 345E+08 290E+08 343E+08 200E+08 267E+08 244E+08 258E+08 288E+08 394E+07 249E+08 216E+08 241E+08 800E+06 340E+08 168E+08 257E+08 240E+08 251E+08 233E+08 251E+08 178E+08 259E+08 209E+08 238E+07 318E+08 320E+08 318E+08 323E+08 PAF-C16 273E+08 146E+08 362E+08 362E+08 373E+08 339E+08 296E+08 338E+08 311E+08 491E+08 456E+08 166E+08 249E+08 316E+08 271E+08 424E+08 317E+08 335E+08 253E+08 547E+08 315E+08 306E+08 258E+08 350E+08 559E+08 507E+08 464E+08 565E+08 PC(36:1) 250E+08 263E+08 404E+08 276E+08 390E+08 315E+08 311E+08 331E+08 226E+07 369E+08 237E+08 271E+08 268E+08 252E+08 169E+08 354E+08 228E+08 312E+08 253E+08 409E+08 278E+08 246E+08 898E+07 327E+08 387E+08 361E+08 357E+08 349E+08 LEUCINE_NORLEUCINE 213E+08 249E+08 157E+08 346E+08 144E+08 205E+08 229E+08 406E+08 190E+09 191E+08 540E+08 219E+08 245E+08 154E+08 526E+08 145E+08 446E+08 147E+08 213E+08 246E+08 367E+08 207E+08 461E+08 338E+08 554E+08 512E+08 444E+08 449E+08 PC(25:0) 207E+08 346E+08 288E+08 646E+07 142E+08 152E+08 105E+08 142E+08 477E+06 860E+07 370E+07 789E+07 263E+07 299E+08 619E+07 792E+07 790E+07 241E+08 679E+07 118E+08 598E+07 654E+07 191E+07 849E+07 144E+08 142E+08 140E+08 159E+08 PC(36:3) 196E+08 322E+08 658E+08 541E+08 687E+08 392E+08 650E+08 692E+08 445E+07 619E+08 359E+08 303E+08 607E+08 250E+08 360E+08 706E+08 385E+08 460E+08 405E+08 111E+09 422E+08 472E+08 126E+08 417E+08 751E+08 704E+08 705E+08 685E+08 L-GLUTAMINE 192E+08 233E+08 156E+08 911E+08 202E+08 221E+08 206E+08 469E+08 367E+09 188E+08 153E+09 224E+08 520E+08 214E+08 837E+08 204E+08 607E+08 188E+08 236E+08 240E+08 442E+08 307E+08 176E+09 275E+08 699E+08 651E+08 442E+08 463E+08 L-PHENYLALANINE 176E+08 267E+08 861E+07 787E+07 102E+08 134E+08 192E+08 245E+08 964E+07 123E+08 726E+07 306E+08 146E+08 943E+07 177E+08 111E+08 216E+08 117E+08 148E+08 161E+08 394E+08 123E+08 833E+07 139E+08 255E+08 249E+08 252E+08 260E+08 PC(32:0) 171E+08 979E+07 619E+07 483E+07 720E+07 811E+07 918E+07 841E+07 449E+06 792E+07 411E+07 961E+07 988E+07 763E+07 536E+07 728E+07 622E+07 773E+07 664E+07 964E+07 808E+07 801E+07 481E+07 748E+07 115E+08 108E+08 114E+08 105E+08 TRIGONELLINE 171E+08 263E+08 163E+08 423E+08 162E+08 209E+08 289E+08 259E+08 786E+08 252E+08 567E+08 398E+08 320E+08 157E+08 299E+08 212E+08 738E+08 168E+08 156E+08 312E+08 740E+08 190E+08 293E+08 412E+08 413E+08 380E+08 356E+08 375E+08 PC(21:0) 167E+08 150E+08 125E+08 481E+07 863E+07 109E+08 566E+07 837E+07 776E+06 765E+07 452E+07 102E+08 131E+06 120E+08 474E+07 573E+07 739E+07 144E+08 669E+07 705E+07 848E+07 689E+07 536E+07 210E+07 117E+08 113E+08 122E+08 130E+08 L-TRYPTOPHAN 160E+08 195E+08 505E+07 119E+08 811E+07 148E+08 194E+08 302E+08 476E+08 203E+08 493E+08 187E+08 311E+08 150E+08 277E+08 104E+08 250E+08 820E+07 161E+08 113E+08 325E+08 177E+08 517E+08 275E+08 296E+08 311E+08 313E+08 345E+08 PC(O-16:2/2:0) 149E+08 272E+08 261E+08 329E+08 270E+08 195E+08 334E+08 346E+08 636E+07 507E+08 338E+08 161E+08 255E+08 125E+08 210E+08 307E+08 225E+08 212E+08 228E+08 492E+08 272E+08 349E+08 172E+08 218E+08 391E+08 356E+08 369E+08 452E+08 PC(36:4) 147E+08 228E+08 254E+08 339E+08 680E+08 259E+08 721E+08 563E+08 301E+07 707E+08 317E+08 373E+08 517E+08 801E+07 234E+08 991E+08 488E+08 373E+08 363E+08 117E+09 717E+08 843E+08 157E+08 195E+08 760E+08 701E+08 729E+08 707E+08 SN-GLYCERO-3-PHOSPHOCHOLINE 128E+08 683E+07 302E+08 323E+09 571E+08 298E+08 233E+08 118E+09 972E+09 426E+08 410E+09 886E+07 950E+08 922E+08 240E+09 597E+08 125E+09 436E+08 128E+09 742E+08 411E+08 756E+08 320E+09 181E+09 266E+09 248E+09 104E+09 113E+09 C2-CARNITINE 117E+08 967E+07 763E+07 370E+08 109E+08 195E+08 131E+08 259E+08 161E+09 173E+08 556E+08 805E+07 356E+08 121E+08 359E+08 953E+07 198E+08 113E+08 174E+08 119E+08 133E+08 170E+08 438E+08 145E+08 442E+08 348E+08 287E+08 353E+08 L-VALINE 107E+08 122E+08 909E+07 335E+08 104E+08 108E+08 151E+08 253E+08 238E+09 115E+08 534E+08 125E+08 216E+08 991E+07 411E+08 107E+08 367E+08 946E+07 151E+08 188E+08 265E+08 130E+08 514E+08 241E+08 403E+08 374E+08 284E+08 290E+08 LPC(20:4) 104E+08 104E+08 119E+08 231E+08 290E+08 200E+08 322E+08 271E+08 234E+08 760E+08 506E+08 822E+07 332E+08 731E+07 168E+08 361E+08 216E+08 162E+08 241E+08 515E+08 233E+08 499E+08 232E+08 126E+08 411E+08 364E+08 394E+08 453E+08 PC(O-16:1/2:0) 101E+08 899E+07 314E+08 287E+08 194E+08 180E+08 170E+08 226E+08 507E+07 280E+08 235E+08 751E+07 159E+08 142E+08 170E+08 182E+08 114E+08 173E+08 147E+08 333E+08 123E+08 138E+08 994E+07 186E+08 273E+08 259E+08 246E+08 292E+08 CYTOSINE 991E+07 104E+08 874E+07 275E+08 126E+08 107E+08 168E+08 226E+08 178E+09 136E+08 774E+08 174E+08 331E+08 100E+08 340E+08 128E+08 248E+08 103E+08 931E+07 156E+08 195E+08 132E+08 744E+08 131E+08 333E+08 315E+08 264E+08 270E+08 PC(38:6) 969E+07 118E+08 196E+08 344E+08 586E+08 201E+08 599E+08 484E+08 191E+07 637E+08 224E+08 243E+08 524E+08 514E+07 183E+08 836E+08 273E+08 279E+08 286E+08 889E+08 384E+08 581E+08 110E+08 247E+08 585E+08 533E+08 589E+08 570E+08 L-HISTIDINE 883E+07 106E+08 926E+07 786E+08 113E+08 117E+08 175E+08 322E+08 319E+09 147E+08 108E+09 243E+08 495E+08 238E+08 108E+09 227E+08 737E+08 201E+08 272E+08 339E+08 515E+08 361E+08 986E+08 399E+08 480E+08 745E+08 530E+08 570E+08 SM(34:1) 878E+07 102E+08 407E+07 441E+07 695E+07 957E+07 802E+07 731E+07 109E+07 847E+07 544E+07 127E+08 113E+08 912E+07 642E+07 623E+07 865E+07 614E+07 803E+07 937E+07 926E+07 344E+07 868E+07 107E+08 122E+08 114E+08 114E+08 127E+08 LPC(16:1) 870E+07 711E+07 505E+08 300E+08 240E+08 200E+08 204E+08 226E+08 160E+08 311E+08 226E+08 629E+07 171E+08 124E+08 146E+08 197E+08 959E+07 247E+08 122E+08 434E+08 889E+07 112E+08 108E+08 157E+08 271E+08 254E+08 284E+08 322E+08 C4-CARNITINE 705E+07 782E+07 161E+07 384E+07 284E+07 295E+07 781E+07 114E+08 166E+09 511E+07 130E+08 347E+07 179E+08 189E+07 843E+07 233E+07 986E+07 244E+07 489E+07 211E+07 124E+08 243E+07 546E+07 208E+07 262E+08 221E+08 170E+08 212E+08 LPC(22:6) 607E+07 559E+07 755E+07 225E+08 209E+08 133E+08 250E+08 247E+08 153E+08 665E+08 438E+08 389E+07 340E+08 488E+07 131E+08 304E+08 142E+08 131E+08 200E+08 418E+08 144E+08 448E+08 172E+08 111E+08 334E+08 296E+08 315E+08 370E+08 URACIL 576E+07 108E+08 913E+06 405E+07 218E+07 180E+07 499E+07 974E+07 183E+08 352E+07 100E+08 797E+07 595E+07 157E+07 987E+07 116E+07 839E+07 119E+07 163E+07 150E+07 731E+07 156E+07 262E+08 162E+07 979E+07 102E+08 923E+07 979E+07 DEOXYCARNITINE 572E+07 448E+07 344E+07 239E+08 499E+07 442E+07 578E+07 129E+08 128E+09 558E+07 412E+08 324E+07 253E+08 462E+07 187E+08 422E+07 126E+08 446E+07 103E+08 602E+07 695E+07 689E+07 293E+08 858E+07 265E+08 196E+08 146E+08 181E+08 L-ARGININE 489E+07 889E+06 489E+07 823E+08 116E+08 949E+07 119E+08 584E+08 459E+09 135E+08 141E+09 971E+07 902E+08 191E+08 117E+09 189E+08 714E+08 151E+08 108E+07 375E+08 391E+08 228E+08 116E+09 618E+08 728E+08 823E+08 472E+08 504E+08 CHOLESTERYL_ACETATE 422E+07 400E+07 718E+07 552E+07 431E+07 361E+07 440E+07 483E+07 373E+06 595E+07 517E+07 599E+07 419E+07 516E+07 365E+07 431E+07 429E+07 434E+07 323E+07 627E+07 597E+07 959E+07 337E+07 494E+07 730E+07 747E+07 747E+07 718E+07 C3-CARNITINE 419E+07 153E+08 228E+07 119E+08 370E+07 354E+07 718E+07 130E+08 185E+09 684E+07 223E+08 710E+07 214E+08 278E+07 162E+08 335E+07 162E+08 322E+07 207E+08 335E+07 101E+08 460E+07 200E+08 400E+07 270E+08 209E+08 158E+08 198E+08 LPC(20:3) 369E+07 216E+07 963E+07 110E+08 119E+08 614E+07 846E+07 889E+07 552E+07 167E+08 108E+08 205E+07 107E+08 361E+07 634E+07 127E+08 446E+07 604E+07 692E+07 163E+08 415E+07 112E+08 448E+07 675E+07 115E+08 108E+08 121E+08 136E+08 L-TYROSINE 364E+07 389E+07 198E+07 533E+07 271E+07 210E+07 683E+07 711E+07 244E+08 354E+07 603E+07 410E+07 584E+07 190E+07 818E+07 358E+07 100E+08 275E+07 555E+07 477E+07 771E+07 256E+07 552E+07 434E+07 793E+07 725E+07 658E+07 649E+07 PC(38:5) 325E+07 386E+07 941E+07 133E+08 225E+08 756E+07 209E+08 178E+08 193E+07 230E+08 886E+07 754E+07 246E+08 259E+07 881E+07 309E+08 109E+08 103E+08 113E+08 368E+08 140E+08 220E+08 357E+07 923E+07 217E+08 203E+08 227E+08 221E+08 SM(42:2) 305E+07 277E+07 119E+07 162E+07 199E+07 323E+07 269E+07 267E+07 270E+06 346E+07 243E+07 311E+07 311E+07 349E+07 319E+07 157E+07 347E+07 230E+07 334E+07 307E+07 280E+07 906E+06 369E+07 327E+07 332E+07 337E+07 311E+07 357E+07 LPC(18:3) 305E+07 323E+07 225E+07 689E+07 394E+07 322E+07 477E+07 476E+07 143E+08 382E+07 819E+07 311E+07 711E+07 351E+07 529E+07 501E+07 593E+07 431E+07 398E+07 703E+07 456E+07 277E+07 493E+07 451E+07 626E+07 666E+07 471E+07 375E+07 PC(32:1) 304E+07 223E+07 134E+08 737E+07 783E+07 474E+07 608E+07 765E+07 597E+06 544E+07 258E+07 278E+07 534E+07 318E+07 368E+07 788E+07 330E+07 617E+07 446E+07 965E+07 330E+07 646E+07 104E+07 341E+07 730E+07 686E+07 710E+07 660E+07 PC(35:2) 296E+07 457E+07 458E+07 386E+07 584E+07 398E+07 686E+07 592E+07 251E+06 539E+07 289E+07 528E+07 450E+07 335E+07 352E+07 540E+07 412E+07 586E+07 370E+07 671E+07 530E+07 428E+07 161E+07 519E+07 609E+07 549E+07 527E+07 520E+07 PC(34:3) 289E+07 388E+07 105E+08 108E+08 100E+08 542E+07 100E+08 971E+07 886E+06 816E+07 537E+07 398E+07 791E+07 287E+07 507E+07 936E+07 543E+07 850E+07 537E+07 172E+08 596E+07 113E+08 213E+07 381E+07 105E+08 960E+07 941E+07 919E+07 PANTOTHENIC_ACID 280E+07 381E+07 900E+06 851E+07 165E+07 201E+07 265E+07 544E+07 843E+08 240E+07 219E+08 580E+07 114E+08 172E+07 917E+07 166E+07 105E+08 123E+07 263E+07 196E+07 715E+07 310E+07 136E+08 328E+07 115E+08 109E+08 750E+07 736E+07 L-ALANINE 244E+07 577E+07 153E+07 110E+08 189E+07 221E+07 542E+07 902E+07 445E+08 204E+07 211E+08 591E+07 659E+07 209E+07 179E+08 275E+07 209E+08 224E+07 709E+07 363E+07 157E+08 333E+07 273E+08 437E+07 108E+08 126E+08 873E+07 738E+07 4-AMINOBUTANOATE 238E+07 349E+07 755E+06 406E+07 132E+07 155E+07 204E+07 285E+07 201E+08 108E+07 968E+07 440E+07 531E+07 146E+07 507E+07 165E+07 681E+07 124E+07 269E+07 137E+07 657E+07 184E+07 149E+08 185E+07 453E+07 445E+07 344E+07 341E+07 L-LYSINE 235E+07 283E+07 297E+07 515E+08 454E+07 473E+07 997E+07 250E+08 320E+09 658E+07 118E+09 651E+07 433E+08 131E+08 626E+08 985E+07 364E+08 568E+07 120E+08 169E+08 196E+08 178E+08 294E+08 171E+08 443E+08 365E+08 314E+08 325E+08 SM(42:3) 232E+07 228E+07 160E+07 169E+07 211E+07 205E+07 257E+07 243E+07 131E+06 209E+07 181E+07 300E+07 379E+07 198E+07 236E+07 174E+07 250E+07 215E+07 212E+07 317E+07 245E+07 107E+07 200E+07 212E+07 287E+07 292E+07 267E+07 309E+07 SM(34:2) 218E+07 313E+07 261E+07 224E+07 272E+07 240E+07 321E+07 288E+07 377E+06 227E+07 186E+07 335E+07 401E+07 179E+07 184E+07 232E+07 242E+07 287E+07 212E+07 381E+07 264E+07 159E+07 175E+07 252E+07 373E+07 346E+07 343E+07 396E+07 Thiamine 208E+07 248E+07 228E+05 669E+05 245E+05 117E+07 405E+06 141E+07 200E+06 828E+06 304E+07 226E+07 486E+03 252E+06 110E+07 730E+04 223E+07 137E+06 458E+06 423E+04 257E+07 205E+06 844E+07 200E+05 803E+06 879E+06 746E+06 807E+06 L-METHIONINE 205E+07 631E+07 158E+07 525E+07 243E+07 243E+07 495E+07 713E+07 174E+08 231E+07 561E+07 780E+07 820E+07 160E+07 600E+07 211E+07 680E+07 256E+07 303E+07 406E+07 755E+07 233E+07 419E+07 539E+07 738E+07 657E+07 588E+07 570E+07 3-AMINO-4-HYDROXYBENZOIC_ACID 203E+07 133E+07 378E+07 492E+07 346E+07 227E+07 241E+07 282E+07 335E+07 396E+07 431E+07 144E+07 601E+07 225E+07 335E+07 489E+07 237E+07 294E+07 239E+07 424E+07 225E+07 201E+07 382E+07 221E+07 351E+07 368E+07 379E+07 403E+07 CITRULLINE 201E+07 146E+07 169E+07 951E+07 296E+07 309E+07 593E+07 128E+08 871E+08 382E+07 206E+08 419E+07 211E+08 470E+07 156E+08 559E+07 121E+08 434E+07 828E+07 706E+07 127E+08 629E+07 193E+08 126E+08 145E+08 181E+08 106E+08 114E+08 5-AMINOPENTANOATE 196E+07 807E+06 873E+06 638E+07 504E+07 151E+08 484E+07 652E+07 306E+08 375E+07 325E+08 110E+07 377E+08 460E+07 209E+08 553E+07 613E+07 318E+07 638E+07 836E+07 487E+07 641E+07 217E+08 254E+08 132E+08 102E+08 761E+07 974E+07 LPC(14:0) 194E+07 135E+07 463E+07 246E+07 210E+07 291E+07 245E+07 261E+07 712E+06 462E+07 214E+07 136E+07 185E+07 248E+07 156E+07 251E+07 167E+07 250E+07 167E+07 380E+07 171E+07 186E+07 119E+07 265E+07 299E+07 305E+07 366E+07 388E+07 L-THREONINE 182E+07 389E+07 140E+07 121E+08 215E+07 231E+07 511E+07 826E+07 588E+08 230E+07 164E+08 400E+07 642E+07 235E+07 153E+08 292E+07 159E+08 255E+07 474E+07 483E+07 102E+08 300E+07 191E+08 675E+07 107E+08 114E+08 737E+07 724E+07 SARCOSINE 180E+07 290E+07 154E+07 628E+07 150E+07 247E+07 197E+07 321E+07 286E+07 146E+07 112E+08 346E+07 415E+06 222E+07 510E+07 177E+07 466E+07 158E+07 281E+07 222E+07 415E+07 173E+07 136E+08 250E+07 374E+07 388E+07 247E+07 261E+07 PC(O-18:4/2:0) 176E+07 235E+07 152E+07 432E+07 421E+07 275E+07 490E+07 529E+07 692E+07 126E+08 106E+08 191E+07 658E+07 121E+07 357E+07 731E+07 450E+07 278E+07 444E+07 984E+07 440E+07 968E+07 445E+07 231E+07 843E+07 775E+07 703E+07 884E+07 HISTAMINE 167E+07 899E+06 586E+06 265E+07 118E+07 118E+07 288E+07 399E+07 239E+08 201E+07 528E+07 103E+07 134E+08 797E+06 439E+07 124E+07 285E+07 105E+07 250E+07 249E+07 134E+07 103E+08 350E+07 162E+07 448E+07 569E+07 538E+07 565E+07 NEPSILON,NEPSILON,NEPSILON-TRIMET 166E+07 903E+06 844E+06 109E+08 107E+07 168E+07 117E+07 539E+07 469E+08 991E+06 156E+08 204E+07 205E+07 193E+07 109E+08 167E+07 111E+08 152E+07 141E+07 241E+07 600E+07 169E+07 221E+08 485E+07 991E+07 101E+08 311E+07 398E+07 LPC(20:0) 161E+07 148E+07 796E+07 801E+07 510E+07 203E+07 319E+07 459E+07 886E+05 235E+07 186E+07 135E+07 854E+06 181E+07 256E+07 464E+07 164E+07 790E+07 183E+07 111E+08 180E+07 160E+07 127E+07 178E+07 481E+07 435E+07 454E+07 528E+07 5,6-DIHYDROURACIL 152E+07 202E+07 382E+06 210E+07 584E+06 626E+06 968E+06 209E+07 128E+08 821E+06 744E+07 156E+07 738E+06 462E+06 409E+07 597E+06 554E+07 499E+06 613E+06 783E+06 445E+07 703E+06 102E+08 924E+06 297E+07 283E+07 194E+07 219E+07 PC(38:2) 149E+07 168E+07 635E+07 437E+07 654E+07 259E+07 451E+07 484E+07 173E+06 402E+07 173E+07 238E+07 318E+07 166E+07 228E+07 662E+07 208E+07 508E+07 290E+07 789E+07 256E+07 250E+07 555E+06 293E+07 471E+07 438E+07 476E+07 445E+07 UROCANATE 147E+07 565E+06 297E+07 151E+08 562E+07 396E+07 378E+07 119E+08 163E+09 616E+07 169E+08 124E+07 602E+07 350E+07 147E+08 478E+07 785E+07 360E+07 150E+07 287E+07 303E+07 161E+07 104E+08 146E+07 211E+08 199E+08 174E+08 186E+08 PC(40:6) 135E+07 164E+07 204E+07 358E+07 850E+07 262E+07 667E+07 523E+07 254E+06 104E+08 323E+07 399E+07 885E+07 732E+06 215E+07 149E+08 385E+07 336E+07 370E+07 123E+08 616E+07 947E+07 133E+07 370E+07 782E+07 786E+07 863E+07 805E+07 ALLANTOIN 129E+07 986E+06 836E+06 262E+07 115E+07 142E+07 143E+07 193E+07 699E+07 186E+07 399E+07 157E+07 236E+07 140E+07 322E+07 133E+07 242E+07 122E+07 158E+07 204E+07 216E+07 101E+07 298E+07 163E+07 269E+07 276E+07 239E+07 262E+07 PC(35:1) 123E+07 130E+07 212E+07 144E+07 204E+07 189E+07 180E+07 197E+07 769E+05 180E+07 104E+07 169E+07 150E+07 157E+07 125E+07 154E+07 116E+07 220E+07 148E+07 202E+07 146E+07 132E+07 572E+06 234E+07 205E+07 188E+07 182E+07 179E+07 BETA-ALANINE 122E+07 129E+07 680E+06 303E+07 100E+07 102E+07 166E+07 238E+07 149E+08 636E+06 426E+07 134E+07 423E+07 987E+06 408E+07 105E+07 307E+07 170E+07 204E+07 134E+07 173E+07 146E+07 708E+07 130E+07 293E+07 303E+07 215E+07 214E+07 L-GLUTAMIC_ACID 121E+07 112E+07 640E+06 136E+08 103E+07 130E+07 156E+07 540E+07 734E+08 149E+07 201E+08 699E+06 444E+07 393E+07 147E+08 150E+07 640E+07 111E+07 491E+07 140E+07 210E+07 208E+07 156E+08 501E+07 805E+07 850E+07 362E+07 370E+07 PC(O-14:1/2:0) 118E+07 958E+06 518E+07 311E+07 239E+07 235E+07 208E+07 234E+07 000E+00 284E+07 171E+07 812E+06 149E+07 136E+07 148E+07 183E+07 940E+06 217E+07 136E+07 387E+07 944E+06 105E+07 764E+06 181E+07 264E+07 227E+07 265E+07 302E+07 C5-CARNITINE 111E+07 272E+07 411E+06 151E+07 898E+06 728E+06 144E+07 207E+07 177E+08 117E+07 366E+07 143E+07 358E+07 460E+06 234E+07 683E+06 258E+07 627E+06 124E+07 717E+06 306E+07 751E+06 409E+07 592E+06 279E+07 232E+07 192E+07 223E+07 SM(33:1) 106E+07 144E+07 574E+06 613E+06 648E+06 840E+06 867E+06 865E+06 926E+05 754E+06 683E+06 154E+07 119E+07 834E+06 638E+06 438E+06 114E+07 618E+06 758E+06 625E+06 133E+07 435E+06 980E+06 102E+07 136E+07 115E+07 113E+07 140E+07 PC(36:5) 102E+07 207E+07 380E+07 515E+07 679E+07 192E+07 620E+07 671E+07 217E+07 631E+07 358E+07 257E+07 665E+07 179E+07 409E+07 866E+07 417E+07 306E+07 310E+07 122E+08 532E+07 817E+07 229E+07 364E+07 682E+07 629E+07 671E+07 622E+07 C14-CARNITINE 971E+06 883E+06 953E+06 769E+06 786E+06 234E+07 141E+07 174E+07 485E+05 384E+07 275E+07 109E+07 156E+07 143E+07 152E+07 112E+07 900E+06 112E+07 988E+06 147E+07 879E+06 164E+07 160E+07 110E+07 224E+07 231E+07 230E+07 233E+07 METHYLGUANIDINE 950E+06 168E+07 503E+06 138E+07 745E+06 678E+06 167E+07 186E+07 495E+05 991E+06 270E+07 203E+07 165E+07 600E+06 202E+07 897E+06 381E+07 108E+07 131E+07 135E+07 404E+07 797E+06 237E+07 160E+07 245E+07 242E+07 234E+07 242E+07 SM(34:0) 870E+06 102E+07 401E+06 429E+06 689E+06 967E+06 798E+06 743E+06 873E+05 841E+06 527E+06 129E+07 112E+07 910E+06 642E+06 626E+06 871E+06 601E+06 815E+06 936E+06 924E+06 348E+06 874E+06 108E+07 122E+07 114E+07 114E+07 128E+07 PC(O-20:6/2:0) 824E+06 114E+07 833E+06 238E+07 224E+07 132E+07 273E+07 293E+07 115E+08 812E+07 492E+07 724E+06 417E+07 592E+06 154E+07 381E+07 166E+07 166E+07 230E+07 579E+07 160E+07 555E+07 194E+07 127E+07 437E+07 428E+07 393E+07 464E+07 3-UREIDOPROPIONATE 798E+06 114E+07 162E+06 105E+07 259E+06 291E+06 483E+06 110E+07 810E+07 453E+06 449E+07 797E+06 310E+06 267E+06 227E+07 278E+06 316E+07 255E+06 326E+06 326E+06 254E+07 320E+06 609E+07 475E+06 152E+07 149E+07 970E+06 113E+07 PC(O-16:3/2:0) 778E+06 727E+06 133E+07 143E+07 102E+07 101E+07 118E+07 126E+07 273E+06 163E+07 111E+07 848E+06 145E+07 121E+07 122E+07 150E+07 143E+07 215E+04 237E+04 233E+07 138E+07 137E+07 853E+06 152E+07 166E+07 215E+07 227E+07 236E+07 N(PAI)-METHYL-L-HISTIDINE 759E+06 805E+06 112E+07 193E+08 197E+07 220E+07 283E+07 661E+07 211E+09 184E+07 000E+00 289E+07 508E+08 294E+07 196E+08 451E+07 971E+07 402E+07 633E+07 829E+07 553E+07 864E+06 000E+00 483E+07 198E+08 223E+08 124E+08 181E+08 4-HYDROXY-L-PROLINE 756E+06 924E+06 827E+06 137E+08 760E+06 850E+06 198E+07 397E+07 358E+08 746E+06 167E+08 105E+07 539E+07 102E+07 860E+07 127E+07 603E+07 128E+07 197E+07 307E+07 426E+07 167E+07 166E+08 278E+07 586E+07 593E+07 306E+07 337E+07 L-SERINE 676E+06 825E+06 669E+06 627E+07 778E+06 783E+06 136E+07 263E+07 243E+08 731E+06 746E+07 965E+06 263E+07 101E+07 590E+07 113E+07 454E+07 101E+07 158E+07 155E+07 271E+07 160E+07 742E+07 254E+07 419E+07 407E+07 272E+07 260E+07 SM(40:2) 661E+06 533E+06 109E+07 128E+07 139E+07 616E+06 106E+07 130E+07 115E+05 510E+06 537E+06 642E+06 606E+06 526E+06 103E+07 124E+07 664E+06 147E+07 946E+06 201E+07 647E+06 237E+06 596E+06 628E+06 125E+07 124E+07 113E+07 133E+07 PHOSPHOCHOLINE 628E+06 565E+06 115E+07 290E+08 164E+07 914E+06 996E+06 659E+07 138E+09 369E+06 267E+08 412E+06 267E+07 243E+07 301E+08 176E+07 145E+08 128E+07 736E+07 116E+07 280E+07 119E+07 289E+08 318E+07 106E+08 111E+08 268E+07 282E+07 ADENINE 571E+06 396E+07 512E+06 904E+06 732E+06 598E+06 120E+07 304E+07 142E+07 603E+06 101E+07 220E+07 257E+07 394E+06 159E+07 705E+06 111E+07 509E+06 861E+06 904E+06 220E+07 229E+06 141E+07 656E+06 171E+07 160E+07 138E+07 144E+07 LPC(20:2) 548E+06 329E+06 272E+07 194E+07 227E+07 127E+07 170E+07 183E+07 628E+06 260E+07 136E+07 243E+06 181E+07 726E+06 133E+07 184E+07 540E+06 130E+07 161E+07 355E+07 556E+06 126E+07 485E+06 141E+07 200E+07 167E+07 191E+07 216E+07 PC(30:0) 510E+06 367E+06 487E+06 364E+06 457E+06 452E+06 573E+06 521E+06 409E+05 453E+06 286E+06 387E+06 700E+06 514E+06 449E+06 533E+06 468E+06 497E+06 394E+06 538E+06 426E+06 415E+06 191E+06 371E+06 650E+06 614E+06 607E+06 640E+06 PC(33:2) 506E+06 121E+07 997E+06 106E+07 123E+07 770E+06 179E+07 167E+07 535E+05 122E+07 583E+06 933E+06 962E+06 538E+06 844E+06 131E+07 982E+06 133E+07 781E+06 237E+07 116E+07 136E+07 397E+06 122E+07 152E+07 141E+07 142E+07 139E+07 HIPPURATE 484E+06 256E+06 644E+06 247E+07 129E+07 116E+07 162E+07 382E+07 167E+08 510E+07 804E+07 128E+06 217E+07 126E+07 342E+07 166E+07 224E+07 127E+07 117E+07 134E+07 115E+07 836E+06 243E+07 785E+06 495E+07 480E+07 415E+07 424E+07 URIDINE 420E+06 846E+06 590E+05 264E+06 153E+06 127E+06 371E+06 737E+06 120E+07 244E+06 701E+06 616E+06 420E+06 108E+06 751E+06 698E+05 623E+06 825E+05 105E+06 760E+05 585E+06 114E+06 204E+07 108E+06 689E+06 757E+06 679E+06 699E+06 PC(8:0) 418E+06 331E+06 338E+06 457E+06 281E+06 383E+06 271E+06 425E+06 614E+06 397E+06 449E+06 222E+06 264E+04 466E+06 366E+06 220E+06 384E+06 400E+06 359E+06 413E+06 363E+06 127E+06 364E+06 298E+06 510E+06 543E+06 570E+06 543E+06 SM(36:2) 409E+06 525E+06 205E+06 227E+06 244E+06 503E+06 375E+06 365E+06 605E+04 326E+06 506E+06 718E+06 559E+06 323E+06 281E+06 239E+06 407E+06 235E+06 289E+06 383E+06 506E+06 213E+06 557E+06 404E+06 698E+06 708E+06 542E+06 717E+06 L-ASPARAGINE 409E+06 807E+06 273E+06 356E+07 413E+06 511E+06 102E+07 189E+07 134E+08 437E+06 516E+07 108E+07 166E+07 752E+06 491E+07 616E+06 433E+07 623E+06 593E+06 983E+06 312E+07 924E+06 665E+07 171E+07 233E+07 269E+07 166E+07 155E+07 SM(36:1) 408E+06 383E+06 948E+05 117E+06 140E+06 485E+06 293E+06 278E+06 732E+04 269E+06 317E+06 645E+06 380E+06 265E+06 245E+06 138E+06 407E+06 159E+06 277E+06 248E+06 425E+06 140E+06 656E+06 372E+06 467E+06 451E+06 438E+06 462E+06 LPE(16:0) 408E+06 440E+06 105E+07 865E+06 101E+07 570E+06 132E+07 149E+07 433E+06 148E+07 619E+06 330E+06 236E+07 403E+06 719E+06 970E+06 674E+06 788E+06 615E+06 181E+07 954E+06 156E+07 143E+06 929E+06 153E+07 140E+07 155E+07 150E+07 PC(33:0) 404E+06 206E+06 260E+06 177E+06 305E+06 265E+06 273E+06 327E+06 241E+05 324E+06 118E+06 204E+06 295E+06 267E+06 189E+06 239E+06 193E+06 295E+06 245E+06 328E+06 189E+06 244E+06 105E+06 364E+06 300E+06 298E+06 298E+06 271E+06 SM(41:2) 384E+06 347E+06 214E+06 270E+06 279E+06 378E+06 308E+06 386E+06 739E+04 315E+06 300E+06 431E+06 422E+06 329E+06 401E+06 178E+06 419E+06 396E+06 397E+06 395E+06 405E+06 114E+06 440E+06 353E+06 444E+06 441E+06 409E+06 478E+06 SM(32:1) 373E+06 366E+06 295E+06 283E+06 278E+06 330E+06 327E+06 317E+06 125E+05 364E+06 339E+06 382E+06 412E+06 413E+06 271E+06 306E+06 382E+06 264E+06 300E+06 369E+06 381E+06 238E+06 308E+06 538E+06 577E+06 510E+06 492E+06 612E+06 PC(35:3) 345E+06 590E+06 867E+06 935E+06 935E+06 571E+06 121E+07 120E+07 550E+05 937E+06 518E+06 682E+06 901E+06 402E+06 690E+06 907E+06 642E+06 107E+07 651E+06 169E+07 804E+06 105E+07 244E+06 691E+06 112E+07 104E+07 100E+07 100E+07 C8-CARNITINE 326E+06 311E+06 648E+05 334E+05 104E+06 169E+06 247E+06 479E+06 666E+04 306E+06 105E+06 194E+06 513E+06 921E+05 160E+06 966E+05 297E+06 113E+06 104E+06 892E+05 567E+06 734E+05 667E+05 562E+05 299E+06 297E+06 307E+06 363E+06 PC(32:2) 286E+06 362E+06 175E+07 127E+07 961E+06 615E+06 103E+07 111E+07 676E+05 813E+06 428E+06 367E+06 910E+06 382E+06 560E+06 114E+07 559E+06 874E+06 569E+06 170E+07 539E+06 119E+07 157E+06 403E+06 116E+07 104E+07 114E+07 108E+07 LAUROYLCARNITINE 277E+06 282E+06 244E+06 241E+06 237E+06 542E+06 472E+06 589E+06 596E+06 120E+07 905E+06 344E+06 798E+06 350E+06 513E+06 309E+06 299E+06 346E+06 312E+06 426E+06 348E+06 529E+06 564E+06 271E+06 713E+06 747E+06 730E+06 751E+06 NALPHA-ACETYL-L-LYSINE 276E+06 336E+06 211E+06 895E+06 379E+06 321E+06 635E+06 713E+06 730E+07 430E+06 196E+07 526E+06 653E+06 427E+06 115E+07 580E+06 101E+07 469E+06 644E+06 102E+07 741E+06 579E+06 214E+07 450E+06 114E+07 129E+07 121E+07 136E+07 PC(31:0) 267E+06 217E+06 123E+06 106E+06 166E+06 181E+06 255E+06 210E+06 226E+04 167E+06 908E+05 173E+06 211E+06 187E+06 152E+06 174E+06 182E+06 212E+06 163E+06 267E+06 192E+06 160E+06 965E+05 205E+06 246E+06 254E+06 250E+06 247E+06 ADENOSINE_5'-MONOPHOSPHATE 266E+06 188E+06 175E+06 105E+07 714E+06 646E+06 992E+06 296E+07 132E+07 172E+04 322E+07 170E+06 000E+00 881E+05 156E+07 785E+06 799E+06 310E+06 185E+07 602E+06 173E+06 756E+06 163E+07 713E+06 101E+07 103E+07 404E+06 491E+06 LPC(22:1) 255E+06 269E+06 100E+07 108E+07 673E+06 395E+06 524E+06 721E+06 103E+06 442E+06 377E+06 252E+06 363E+06 277E+06 455E+06 611E+06 329E+06 855E+06 353E+06 187E+07 357E+06 300E+06 261E+06 318E+06 858E+06 747E+06 716E+06 833E+06 PC(37:4) 250E+06 299E+06 341E+06 425E+06 108E+07 492E+06 115E+07 872E+06 135E+05 110E+07 389E+06 733E+06 917E+06 161E+06 429E+06 140E+07 795E+06 706E+06 666E+06 183E+07 116E+07 145E+07 161E+06 437E+06 124E+07 114E+07 118E+07 119E+07 THYMINE 243E+06 239E+06 240E+06 351E+06 280E+06 255E+06 324E+06 424E+06 263E+07 581E+06 533E+06 350E+06 712E+06 208E+06 453E+06 261E+06 375E+06 260E+06 884E+05 365E+06 368E+06 201E+06 475E+06 221E+06 482E+06 413E+06 371E+06 431E+06 GUANIDINOACETATE 243E+06 253E+06 288E+06 146E+07 348E+06 288E+06 620E+06 960E+06 678E+07 375E+06 221E+07 167E+06 189E+07 243E+06 148E+07 451E+06 792E+06 282E+06 538E+06 383E+06 457E+06 502E+06 156E+07 718E+06 951E+06 955E+06 683E+06 721E+06 PC(O-12:0/2:0) 212E+06 188E+06 438E+06 319E+06 183E+06 313E+06 230E+06 242E+06 641E+05 370E+06 279E+06 142E+06 220E+06 236E+06 162E+06 169E+06 169E+06 195E+06 160E+06 261E+06 150E+06 146E+06 197E+06 300E+06 298E+06 269E+06 311E+06 332E+06 PC(40:7) 208E+06 306E+06 103E+07 162E+07 325E+07 866E+06 308E+07 220E+07 898E+06 355E+07 954E+06 600E+06 584E+07 265E+06 110E+07 549E+07 107E+07 111E+07 145E+07 632E+07 156E+07 298E+07 327E+06 105E+07 303E+07 299E+07 332E+07 319E+07 REICHSTEINS_SUBSTANCE_S 188E+06 845E+05 658E+05 116E+06 413E+06 276E+06 270E+06 317E+06 131E+06 528E+06 528E+06 177E+06 196E+07 924E+05 261E+06 817E+06 339E+06 202E+06 440E+06 281E+06 417E+06 471E+06 254E+06 964E+06 462E+06 459E+06 452E+06 488E+06 C10-CARNITINE 186E+06 217E+06 716E+05 959E+05 125E+06 223E+06 214E+06 358E+06 000E+00 466E+06 515E+06 220E+06 501E+06 116E+06 205E+06 111E+06 228E+06 120E+06 150E+06 133E+06 342E+06 115E+06 289E+06 876E+05 272E+06 248E+06 261E+06 272E+06 5-OXO-L-PROLINE 186E+06 368E+06 259E+06 152E+07 358E+06 312E+06 270E+06 728E+06 183E+08 306E+06 243E+07 220E+06 141E+07 309E+06 122E+07 399E+06 714E+06 367E+06 378E+06 459E+06 500E+06 766E+06 184E+07 552E+06 129E+07 133E+07 878E+06 839E+06 SM(38:2) 175E+06 251E+06 138E+06 178E+06 180E+06 199E+06 216E+06 219E+06 000E+00 152E+06 164E+06 296E+06 226E+06 144E+06 165E+06 175E+06 232E+06 155E+06 178E+06 198E+06 250E+06 102E+06 200E+06 182E+06 286E+06 273E+06 249E+06 303E+06 GLYCINE 154E+06 171E+06 136E+06 105E+07 161E+06 174E+06 238E+06 485E+06 581E+07 168E+06 150E+07 204E+06 801E+06 229E+06 120E+07 210E+06 867E+06 236E+06 437E+06 351E+06 469E+06 321E+06 179E+07 291E+06 838E+06 106E+07 625E+06 546E+06 PAF-C18 125E+06 745E+05 792E+06 709E+06 491E+06 171E+06 297E+06 444E+06 803E+05 179E+06 169E+06 921E+05 738E+05 174E+06 243E+06 499E+06 152E+06 876E+06 131E+06 116E+07 151E+06 146E+06 792E+05 140E+06 497E+06 488E+06 491E+06 523E+06 SM(40:3) 124E+06 108E+06 578E+06 459E+06 532E+06 188E+06 384E+06 462E+06 000E+00 140E+06 116E+06 187E+06 235E+06 118E+06 251E+06 476E+06 158E+06 436E+06 241E+06 799E+06 191E+06 887E+05 120E+06 145E+06 387E+06 373E+06 348E+06 407E+06 GUANINE 123E+06 268E+06 649E+05 269E+06 114E+06 984E+05 185E+06 558E+06 921E+06 141E+06 128E+07 301E+06 429E+06 141E+06 712E+06 139E+06 738E+06 130E+06 127E+06 173E+06 123E+07 112E+06 867E+06 276E+06 515E+06 550E+06 445E+06 518E+06 3-METHYLADENINE 123E+06 998E+05 892E+05 220E+06 105E+06 132E+06 262E+06 426E+06 273E+06 330E+06 298E+06 212E+06 368E+06 253E+06 340E+06 140E+06 153E+06 793E+05 969E+05 104E+06 326E+06 795E+05 750E+05 292E+06 238E+06 246E+06 224E+06 224E+06 ADENOSINE 108E+06 200E+06 881E+05 197E+06 118E+06 142E+06 681E+06 115E+07 525E+06 176E+06 640E+06 165E+06 789E+06 110E+06 429E+06 151E+06 262E+06 123E+06 145E+06 139E+06 456E+06 201E+06 394E+06 152E+06 415E+06 382E+06 324E+06 373E+06 LPE(18:2) 978E+05 218E+06 687E+06 617E+06 920E+06 408E+06 979E+06 986E+06 517E+06 171E+07 546E+06 860E+05 223E+07 280E+06 510E+06 904E+06 446E+06 589E+06 556E+06 180E+07 502E+06 146E+07 573E+05 891E+06 115E+07 113E+07 129E+07 121E+07 PC(O-18:2/2:0) 927E+05 646E+05 339E+06 352E+06 301E+06 157E+06 240E+06 327E+06 383E+06 432E+06 267E+06 510E+05 393E+06 121E+06 273E+06 373E+06 119E+06 215E+06 273E+06 633E+06 105E+06 247E+06 913E+05 232E+06 395E+06 353E+06 358E+06 444E+06 SPERMIDINE 906E+05 911E+05 769E+05 100E+06 623E+05 614E+05 166E+06 845E+05 874E+06 104E+06 215E+06 294E+05 423E+06 142E+06 158E+06 866E+05 641E+05 564E+05 533E+06 897E+05 273E+05 176E+06 453E+06 819E+05 119E+06 121E+06 466E+06 177E+06 LPC(19:1) 814E+05 136E+06 728E+05 337E+05 479E+05 972E+05 628E+05 769E+05 000E+00 759E+05 494E+05 137E+06 000E+00 619E+05 618E+05 263E+05 660E+05 795E+05 535E+05 328E+05 641E+05 182E+05 423E+05 200E+05 873E+05 797E+05 725E+05 857E+05 4-IMIDAZOLEACETIC_ACID 787E+05 128E+06 105E+06 547E+06 136E+06 103E+06 195E+06 268E+06 461E+07 187E+06 806E+06 157E+06 306E+06 151E+06 345E+06 186E+06 479E+06 127E+06 201E+06 164E+06 330E+06 216E+06 468E+06 353E+06 412E+06 394E+06 255E+06 310E+06 LPC(18:4) 720E+05 681E+05 749E+06 738E+06 347E+06 327E+06 390E+06 519E+06 653E+06 794E+06 741E+06 120E+06 724E+06 338E+06 388E+06 645E+06 232E+06 795E+06 320E+06 169E+07 233E+06 499E+06 209E+06 196E+06 728E+06 884E+06 136E+07 137E+07 SM(35:1) 592E+05 755E+05 159E+05 213E+05 355E+05 735E+05 502E+05 468E+05 000E+00 460E+05 425E+05 113E+06 650E+05 620E+05 501E+05 308E+05 685E+05 385E+05 550E+05 472E+05 775E+05 209E+05 926E+05 724E+05 911E+05 796E+05 833E+05 827E+05 SM(38:1) 587E+05 694E+05 321E+05 439E+05 456E+05 526E+05 644E+05 665E+05 000E+00 458E+05 120E+05 830E+05 417E+05 366E+05 510E+05 488E+05 737E+05 572E+05 628E+05 652E+05 730E+05 263E+05 763E+05 558E+05 845E+05 796E+05 766E+05 872E+05 LPC(22:4) 544E+05 606E+05 243E+06 296E+06 358E+06 169E+06 325E+06 380E+06 983E+05 612E+06 359E+06 946E+05 679E+06 117E+06 236E+06 515E+06 190E+06 309E+06 319E+06 884E+06 214E+06 367E+06 138E+06 205E+06 464E+06 503E+06 514E+06 591E+06 L-ANSERINE 494E+05 602E+05 743E+05 117E+07 108E+06 597E+05 438E+06 643E+06 205E+08 617E+05 112E+07 479E+05 184E+07 667E+05 122E+07 229E+06 488E+06 239E+06 518E+06 290E+06 195E+06 236E+06 870E+06 202E+06 114E+07 132E+07 713E+06 498E+06 N-ACETYLPUTRESCINE 359E+05 529E+05 652E+05 239E+06 736E+05 783E+05 121E+06 128E+06 506E+06 116E+06 323E+06 788E+05 155E+06 610E+05 215E+06 104E+06 141E+06 461E+05 668E+05 956E+05 166E+06 932E+05 197E+06 119E+06 186E+06 129E+06 100E+06 130E+06 Acetylcholine 299E+05 470E+05 607E+05 791E+05 723E+05 877E+05 591E+05 109E+06 317E+06 158E+06 141E+06 298E+05 281E+06 839E+05 160E+06 983E+05 104E+06 115E+06 898E+05 124E+06 771E+05 628E+05 953E+05 361E+05 153E+06 153E+06 164E+06 166E+06 SM(32:2) 216E+05 194E+05 500E+05 399E+05 398E+05 355E+05 349E+05 444E+05 000E+00 399E+05 333E+05 300E+05 571E+05 294E+05 157E+05 549E+05 318E+05 393E+05 339E+05 586E+05 263E+05 357E+05 278E+04 533E+05 587E+05 478E+05 568E+05 684E+05 CARNOSINE 151E+05 213E+05 275E+05 540E+06 452E+05 563E+05 174E+06 265E+06 707E+07 708E+05 968E+06 415E+05 948E+06 809E+05 627E+06 106E+06 186E+06 154E+06 176E+06 242E+06 107E+06 156E+06 639E+06 917E+05 515E+06 476E+06 315E+06 419E+06 SM(39:1) 110E+05 869E+04 141E+05 193E+05 107E+05 717E+04 157E+05 234E+05 000E+00 563E+04 937E+03 137E+05 170E+04 337E+04 135E+05 825E+04 770E+04 286E+05 138E+05 248E+05 943E+04 237E+04 500E+04 744E+04 116E+05 153E+05 158E+05 799E+04 PC(O-20:4/2:0) 720E+04 160E+05 182E+05 203E+05 322E+05 118E+05 284E+05 325E+05 188E+05 664E+05 436E+05 219E+05 693E+05 712E+04 230E+05 607E+05 150E+05 342E+05 270E+05 108E+06 183E+05 364E+05 122E+05 178E+05 447E+05 597E+05 662E+05 652E+05 PC(O-18:3/2:0) 399E+04 182E+04 166E+07 209E+07 502E+05 129E+07 109E+05 198E+07 189E+07 359E+07 241E+07 571E+06 313E+07 107E+07 139E+07 332E+07 116E+07 178E+07 160E+07 253E+05 109E+07 276E+07 751E+06 130E+07 293E+07 316E+07 353E+07 381E+07 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name RT (min) LPC(16:0) 9.8796237 BETAINE 10.173788 LPC(18:0) 9.6701446 PC(34:2) 7.2009143 L-CARNITINE 10.1336759999999 O-ACETYL-L-CARNITINE 9.5096904 PC(36:2) 7.1117728 CREATININE 3.8304237 PC(34:1) 7.1830853 LPC(18:2) 9.83059669999999 LPC(18:1) 9.7369988 PC(O-14:0/2:0) 9.5943737 CREATINE 9.6389443 TAURINE 4.6960907 NICOTINAMIDE 1.6968958 L-PROLINE 8.9231152 GAMMA-LINOLENIC_ACID 1.2632727 PAF-C16 9.3759799 PC(36:1) 7.1073163 LEUCINE_NORLEUCINE 6.5631454 PC(25:0) 8.16124379999999 PC(36:3) 7.1117728 L-GLUTAMINE 9.8127694 L-PHENYLALANINE 6.2675016 PC(32:0) 7.2913708 TRIGONELLINE 10.173788 PC(21:0) 9.0759754 L-TRYPTOPHAN 5.9290724 PC(O-16:2/2:0) 9.5453464 PC(36:4) 7.0070124 SN-GLYCERO-3-PHOSPHOCHOLINE 16.4205639999999 C2-CARNITINE 9.5096904 L-VALINE 7.5806456 LPC(20:4) 9.6567717 PC(O-16:1/2:0) 9.4383776 CYTOSINE 3.387786 PC(38:6) 6.9579829 L-HISTIDINE 13.557619 SM(34:1) 8.801413 LPC(16:1) 9.9598507 C4-CARNITINE 8.0453627 LPC(22:6) 9.5854589 URACIL 1.683525 DEOXYCARNITINE 9.4918609 L-ARGININE 13.593275 CHOLESTERYL_ACETATE 1.1741331 C3-CARNITINE 8.7242336 LPC(20:3) 9.68797159999999 L-TYROSINE 6.696856 PC(38:5) 6.9490707 SM(42:2) 8.3662691 LPC(18:3) 9.897453 PC(32:1) 7.2646291 PC(35:2) 7.1474289 PC(34:3) 7.2053708 PANTOTHENIC_ACID 1.5886375 L-ALANINE 8.8607169 4-AMINOBUTANOATE 9.7147134 L-LYSINE 14.63329 SM(42:3) 8.3662691 SM(34:2) 8.8236984 Thiamine 12.679581 L-METHIONINE 6.9490707 3-AMINO-4-HYDROXYBENZOIC_ACID 2.2134124 CITRULLINE 10.7719679999999 5-AMINOPENTANOATE 9.22889649999999 LPC(14:0) 10.1113909999999 L-THREONINE 8.5133504 SARCOSINE 9.4383776 PC(O-18:4/2:0) 9.3447796 HISTAMINE 13.152029 NEPSILON,NEPSILON,NEPSILON-TRIMET 17.8899289999999 LPC(20:0) 9.4829487 5,6-DIHYDROURACIL 1.8542105 PC(38:2) 7.0261622 UROCANATE 2.0025938 PC(40:6) 6.8719769 ALLANTOIN 1.7370104 PC(35:1) 7.1385145 BETA-ALANINE 9.6389443 L-GLUTAMIC_ACID 9.3224945 PC(O-14:1/2:0) 9.68797159999999 C5-CARNITINE 7.5079792 SM(33:1) 8.8607169 PC(36:5) 7.0350749 C14-CARNITINE 5.3541138 METHYLGUANIDINE 4.8713157 SM(34:0) 8.801413 PC(O-20:6/2:0) 9.2734674 3-UREIDOPROPIONATE 1.8542105 PC(O-16:3/2:0) 9.5943737 N(PAI)-METHYL-L-HISTIDINE 15.796578 4-HYDROXY-L-PROLINE 9.1174712 L-SERINE 8.9957483 SM(40:2) 8.4286668 PHOSPHOCHOLINE 17.178262 ADENINE 2.580169 LPC(20:2) 9.64785919999999 PC(30:0) 7.3729396 PC(33:2) 7.2365708 HIPPURATE 1.5039541 URIDINE 1.683525 PC(8:0) 11.1775579999999 SM(36:2) 8.6885776 L-ASPARAGINE 9.5408904 SM(36:1) 8.6752046 LPE(16:0) 7.0070124 PC(33:0) 7.2454833 SM(41:2) 8.3974691 SM(32:1) 8.92757319999999 PC(35:3) 7.1385145 C8-CARNITINE 6.2616913 PC(32:2) 7.2869145 LAUROYLCARNITINE 5.6393638 NALPHA-ACETYL-L-LYSINE 10.3311139999999 PC(31:0) 7.3314854 ADENOSINE_5'-MONOPHOSPHATE 10.178247 LPC(22:1) 9.3893507 PC(37:4) 6.9668978 THYMINE 1.5618958 GUANIDINOACETATE 8.8281547 PC(O-12:0/2:0) 9.8350551 PC(40:7) 6.8764329 REICHSTEINS_SUBSTANCE_S 1.3167581 C10-CARNITINE 5.96027 5-OXO-L-PROLINE 3.1145815 SM(38:2) 8.55346499999999 GLYCINE 9.393807 PAF-C18 9.1664986 SM(40:3) 8.4776942 GUANINE 2.3025523 3-METHYLADENINE 6.5052039 ADENOSINE 2.2758106 LPE(18:2) 6.9624415 PC(O-18:2/2:0) 9.3447796 SPERMIDINE 17.840902 LPC(19:1) 8.6083505 4-IMIDAZOLEACETIC_ACID 8.770213 LPC(18:4) 9.9420239 SM(35:1) 8.7286901 SM(38:1) 8.55346499999999 LPC(22:4) 9.5453464 L-ANSERINE 17.6878889999999 N-ACETYLPUTRESCINE 8.415296 Acetylcholine 6.3521869 SM(32:2) 8.973463 CARNOSINE 15.943661 SM(39:1) 8.4776942 PC(O-20:4/2:0) 9.22444 PC(O-18:3/2:0) 9.2199819 METABOLITES_END #END