#METABOLOMICS WORKBENCH basilm_20220506_105941_mwtab.txt DATATRACK_ID:3225 STUDY_ID:ST002112 ANALYSIS_ID:AN004115 PROJECT_ID:PR001338
VERSION             	1
CREATED_ON             	May 18, 2022, 5:28 pm
#PROJECT
PR:PROJECT_TITLE                 	Health benefits of dietary fiber supplementation.
PR:PROJECT_SUMMARY               	Untargeted metabolomics to understand health benefits of dietary fiber
PR:PROJECT_SUMMARY               	supplementation.
PR:INSTITUTE                     	Stanford University
PR:LAST_NAME                     	Lancaster
PR:FIRST_NAME                    	Samuel
PR:ADDRESS                       	240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305
PR:EMAIL                         	slancast@stanford.edu
PR:PHONE                         	6126004033
#STUDY
ST:STUDY_TITLE                   	Global, distinctive and personal changes in molecular and microbial profiles
ST:STUDY_TITLE                   	induced by specific fibers in humans (Untargeted)
ST:STUDY_SUMMARY                 	Dietary fibers act through the microbiome and improve cardiovascular health,
ST:STUDY_SUMMARY                 	metabolic disorders and cancer prevention. To understand health benefits of
ST:STUDY_SUMMARY                 	dietary fiber supplementation we investigated two popular purified fibers,
ST:STUDY_SUMMARY                 	arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We
ST:STUDY_SUMMARY                 	present multi-omic signatures of metabolomics, lipidomics, proteomics,
ST:STUDY_SUMMARY                 	metagenomics, a cytokine panel and clinical measurements on healthy and insulin
ST:STUDY_SUMMARY                 	resistant participants. Each fiber is associated with fiber-dependent
ST:STUDY_SUMMARY                 	biochemical and microbial responses. AX consumption associates with a
ST:STUDY_SUMMARY                 	significant reduction in LDL and an increase in bile acids, contributing to its
ST:STUDY_SUMMARY                 	observed cholesterol reduction. LCI is associated with an increase in
ST:STUDY_SUMMARY                 	Bifidobacterium. However, at the highest LCI dose there is increased
ST:STUDY_SUMMARY                 	inflammation and elevation in the liver enzyme alanine aminotransferase. This
ST:STUDY_SUMMARY                 	study yields insights into the effects of fiber supplementation, it provides
ST:STUDY_SUMMARY                 	insights into mechanisms behind fiber induced cholesterol reduction, and it
ST:STUDY_SUMMARY                 	shows effects of individual, purified fibers on the microbiome.
ST:INSTITUTE                     	Stanford University
ST:LAST_NAME                     	Lancaster
ST:FIRST_NAME                    	Samuel
ST:ADDRESS                       	240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305
ST:EMAIL                         	slancast@stanford.edu
ST:PHONE                         	6126004033
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Male and female
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	1	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=1.RAW
SUBJECT_SAMPLE_FACTORS           	-	2	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=2.RAW
SUBJECT_SAMPLE_FACTORS           	-	3	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=3.RAW
SUBJECT_SAMPLE_FACTORS           	-	4	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=4.RAW
SUBJECT_SAMPLE_FACTORS           	-	5	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=5.RAW
SUBJECT_SAMPLE_FACTORS           	-	6	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=6.RAW
SUBJECT_SAMPLE_FACTORS           	-	8	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=8.RAW
SUBJECT_SAMPLE_FACTORS           	-	9	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=9.RAW
SUBJECT_SAMPLE_FACTORS           	-	11	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=11.RAW
SUBJECT_SAMPLE_FACTORS           	-	12	Fiber:Mix | Timepoint:30 | Sex:M	RAW_FILE_NAME=12.RAW
SUBJECT_SAMPLE_FACTORS           	-	14	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=14.RAW
SUBJECT_SAMPLE_FACTORS           	-	15	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=15.RAW
SUBJECT_SAMPLE_FACTORS           	-	16	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=16.RAW
SUBJECT_SAMPLE_FACTORS           	-	17	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=17.RAW
SUBJECT_SAMPLE_FACTORS           	-	18	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=18.RAW
SUBJECT_SAMPLE_FACTORS           	-	19	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=19.RAW
SUBJECT_SAMPLE_FACTORS           	-	20	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=20.RAW
SUBJECT_SAMPLE_FACTORS           	-	21	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=21.RAW
SUBJECT_SAMPLE_FACTORS           	-	22	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=22.RAW
SUBJECT_SAMPLE_FACTORS           	-	23	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=23.RAW
SUBJECT_SAMPLE_FACTORS           	-	24	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=24.RAW
SUBJECT_SAMPLE_FACTORS           	-	25	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=25.RAW
SUBJECT_SAMPLE_FACTORS           	-	26	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=26.RAW
SUBJECT_SAMPLE_FACTORS           	-	27	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=27.RAW
SUBJECT_SAMPLE_FACTORS           	-	28	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=28.RAW
SUBJECT_SAMPLE_FACTORS           	-	29	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=29.RAW
SUBJECT_SAMPLE_FACTORS           	-	30	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=30.RAW
SUBJECT_SAMPLE_FACTORS           	-	31	Fiber:Inulin | Timepoint:Washout Week 3 | Sex:M	RAW_FILE_NAME=31.RAW
SUBJECT_SAMPLE_FACTORS           	-	32	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=32.RAW
SUBJECT_SAMPLE_FACTORS           	-	33	Fiber:Mix | Timepoint:30 | Sex:M	RAW_FILE_NAME=33.RAW
SUBJECT_SAMPLE_FACTORS           	-	34	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=34.RAW
SUBJECT_SAMPLE_FACTORS           	-	35	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=35.RAW
SUBJECT_SAMPLE_FACTORS           	-	36	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=36.RAW
SUBJECT_SAMPLE_FACTORS           	-	37	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=37.RAW
SUBJECT_SAMPLE_FACTORS           	-	38	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=38.RAW
SUBJECT_SAMPLE_FACTORS           	-	39	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=39.RAW
SUBJECT_SAMPLE_FACTORS           	-	40	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=40.RAW
SUBJECT_SAMPLE_FACTORS           	-	41	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=41.RAW
SUBJECT_SAMPLE_FACTORS           	-	42	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=42.RAW
SUBJECT_SAMPLE_FACTORS           	-	43	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=43.RAW
SUBJECT_SAMPLE_FACTORS           	-	44	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=44.RAW
SUBJECT_SAMPLE_FACTORS           	-	45	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=45.RAW
SUBJECT_SAMPLE_FACTORS           	-	46	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=46.RAW
SUBJECT_SAMPLE_FACTORS           	-	47	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=47.RAW
SUBJECT_SAMPLE_FACTORS           	-	48	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=48.RAW
SUBJECT_SAMPLE_FACTORS           	-	49	Fiber:Mix | Timepoint:30 | Sex:M	RAW_FILE_NAME=49.RAW
SUBJECT_SAMPLE_FACTORS           	-	50	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=50.RAW
SUBJECT_SAMPLE_FACTORS           	-	51	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=51.RAW
SUBJECT_SAMPLE_FACTORS           	-	52	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=52.RAW
SUBJECT_SAMPLE_FACTORS           	-	53	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=53.RAW
SUBJECT_SAMPLE_FACTORS           	-	54	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=54.RAW
SUBJECT_SAMPLE_FACTORS           	-	55	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=55.RAW
SUBJECT_SAMPLE_FACTORS           	-	56	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=56.RAW
SUBJECT_SAMPLE_FACTORS           	-	57	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=57.RAW
SUBJECT_SAMPLE_FACTORS           	-	58	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=58.RAW
SUBJECT_SAMPLE_FACTORS           	-	59	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=59.RAW
SUBJECT_SAMPLE_FACTORS           	-	60	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=60.RAW
SUBJECT_SAMPLE_FACTORS           	-	61	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=61.RAW
SUBJECT_SAMPLE_FACTORS           	-	62	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=62.RAW
SUBJECT_SAMPLE_FACTORS           	-	63	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=63.RAW
SUBJECT_SAMPLE_FACTORS           	-	64	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=64.RAW
SUBJECT_SAMPLE_FACTORS           	-	67	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=67.RAW
SUBJECT_SAMPLE_FACTORS           	-	68	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=68.RAW
SUBJECT_SAMPLE_FACTORS           	-	69	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=69.RAW
SUBJECT_SAMPLE_FACTORS           	-	70	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=70.RAW
SUBJECT_SAMPLE_FACTORS           	-	71	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=71.RAW
SUBJECT_SAMPLE_FACTORS           	-	73	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=73.RAW
SUBJECT_SAMPLE_FACTORS           	-	74	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=74.RAW
SUBJECT_SAMPLE_FACTORS           	-	75	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=75.RAW
SUBJECT_SAMPLE_FACTORS           	-	76	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=76.RAW
SUBJECT_SAMPLE_FACTORS           	-	77	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=77.RAW
SUBJECT_SAMPLE_FACTORS           	-	78	Fiber:Mix | Timepoint:30 | Sex:M	RAW_FILE_NAME=78.RAW
SUBJECT_SAMPLE_FACTORS           	-	79	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=79.RAW
SUBJECT_SAMPLE_FACTORS           	-	80	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=80.RAW
SUBJECT_SAMPLE_FACTORS           	-	81	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=81.RAW
SUBJECT_SAMPLE_FACTORS           	-	82	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=82.RAW
SUBJECT_SAMPLE_FACTORS           	-	83	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=83.RAW
SUBJECT_SAMPLE_FACTORS           	-	84	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=84.RAW
SUBJECT_SAMPLE_FACTORS           	-	85	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=85.RAW
SUBJECT_SAMPLE_FACTORS           	-	86	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=86.RAW
SUBJECT_SAMPLE_FACTORS           	-	87	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=87.RAW
SUBJECT_SAMPLE_FACTORS           	-	88	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=88.RAW
SUBJECT_SAMPLE_FACTORS           	-	89	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=89.RAW
SUBJECT_SAMPLE_FACTORS           	-	90	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=90.RAW
SUBJECT_SAMPLE_FACTORS           	-	91	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=91.RAW
SUBJECT_SAMPLE_FACTORS           	-	92	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=92.RAW
SUBJECT_SAMPLE_FACTORS           	-	93	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=93.RAW
SUBJECT_SAMPLE_FACTORS           	-	94	Fiber:Arabinoxylan | Timepoint:Week 2 | Sex:M	RAW_FILE_NAME=94.RAW
SUBJECT_SAMPLE_FACTORS           	-	95	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=95.RAW
SUBJECT_SAMPLE_FACTORS           	-	96	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=96.RAW
SUBJECT_SAMPLE_FACTORS           	-	97	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=97.RAW
SUBJECT_SAMPLE_FACTORS           	-	98	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=98.RAW
SUBJECT_SAMPLE_FACTORS           	-	99	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=99.RAW
SUBJECT_SAMPLE_FACTORS           	-	100	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=100.RAW
SUBJECT_SAMPLE_FACTORS           	-	101	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=101.RAW
SUBJECT_SAMPLE_FACTORS           	-	102	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=102.RAW
SUBJECT_SAMPLE_FACTORS           	-	103	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=103.RAW
SUBJECT_SAMPLE_FACTORS           	-	104	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=104.RAW
SUBJECT_SAMPLE_FACTORS           	-	105	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=105.RAW
SUBJECT_SAMPLE_FACTORS           	-	106	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=106.RAW
SUBJECT_SAMPLE_FACTORS           	-	107	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=107.RAW
SUBJECT_SAMPLE_FACTORS           	-	108	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=108.RAW
SUBJECT_SAMPLE_FACTORS           	-	109	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=109.RAW
SUBJECT_SAMPLE_FACTORS           	-	110	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=110.RAW
SUBJECT_SAMPLE_FACTORS           	-	111	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=111.RAW
SUBJECT_SAMPLE_FACTORS           	-	112	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=112.RAW
SUBJECT_SAMPLE_FACTORS           	-	113	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=113.RAW
SUBJECT_SAMPLE_FACTORS           	-	114	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=114.RAW
SUBJECT_SAMPLE_FACTORS           	-	115	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=115.RAW
SUBJECT_SAMPLE_FACTORS           	-	116	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=116.RAW
SUBJECT_SAMPLE_FACTORS           	-	117	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=117.RAW
SUBJECT_SAMPLE_FACTORS           	-	118	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=118.RAW
SUBJECT_SAMPLE_FACTORS           	-	119	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=119.RAW
SUBJECT_SAMPLE_FACTORS           	-	120	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=120.RAW
SUBJECT_SAMPLE_FACTORS           	-	122	Fiber:Inulin | Timepoint:- | Sex:M	RAW_FILE_NAME=122.RAW
SUBJECT_SAMPLE_FACTORS           	-	124	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=124.RAW
SUBJECT_SAMPLE_FACTORS           	-	126	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=126.RAW
SUBJECT_SAMPLE_FACTORS           	-	127	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=127.RAW
SUBJECT_SAMPLE_FACTORS           	-	128	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=128.RAW
SUBJECT_SAMPLE_FACTORS           	-	129	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=129.RAW
SUBJECT_SAMPLE_FACTORS           	-	130	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=130.RAW
SUBJECT_SAMPLE_FACTORS           	-	131	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=131.RAW
SUBJECT_SAMPLE_FACTORS           	-	132	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=132.RAW
SUBJECT_SAMPLE_FACTORS           	-	133	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=133.RAW
SUBJECT_SAMPLE_FACTORS           	-	134	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=134.RAW
SUBJECT_SAMPLE_FACTORS           	-	135	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=135.RAW
SUBJECT_SAMPLE_FACTORS           	-	136	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=136.RAW
SUBJECT_SAMPLE_FACTORS           	-	137	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=137.RAW
SUBJECT_SAMPLE_FACTORS           	-	138	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=138.RAW
SUBJECT_SAMPLE_FACTORS           	-	139	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=139.RAW
SUBJECT_SAMPLE_FACTORS           	-	140	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=140.RAW
SUBJECT_SAMPLE_FACTORS           	-	141	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=141.RAW
SUBJECT_SAMPLE_FACTORS           	-	142	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=142.RAW
SUBJECT_SAMPLE_FACTORS           	-	143	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=143.RAW
SUBJECT_SAMPLE_FACTORS           	-	144	Fiber:Arabinoxylan | Timepoint:Washout D30 | Sex:M	RAW_FILE_NAME=144.RAW
SUBJECT_SAMPLE_FACTORS           	-	145	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=145.RAW
SUBJECT_SAMPLE_FACTORS           	-	146	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=146.RAW
SUBJECT_SAMPLE_FACTORS           	-	147	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=147.RAW
SUBJECT_SAMPLE_FACTORS           	-	148	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=148.RAW
SUBJECT_SAMPLE_FACTORS           	-	149	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=149.RAW
SUBJECT_SAMPLE_FACTORS           	-	150	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=150.RAW
SUBJECT_SAMPLE_FACTORS           	-	151	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=151.RAW
SUBJECT_SAMPLE_FACTORS           	-	152	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=152.RAW
SUBJECT_SAMPLE_FACTORS           	-	153	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=153.RAW
SUBJECT_SAMPLE_FACTORS           	-	154	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=154.RAW
SUBJECT_SAMPLE_FACTORS           	-	155	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=155.RAW
SUBJECT_SAMPLE_FACTORS           	-	156	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=156.RAW
SUBJECT_SAMPLE_FACTORS           	-	157	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=157.RAW
SUBJECT_SAMPLE_FACTORS           	-	158	Fiber:Arabinoxylan | Timepoint:Month 1 | Sex:M	RAW_FILE_NAME=158.RAW
SUBJECT_SAMPLE_FACTORS           	-	159	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=159.RAW
SUBJECT_SAMPLE_FACTORS           	-	161	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=161.RAW
SUBJECT_SAMPLE_FACTORS           	-	163	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=163.RAW
SUBJECT_SAMPLE_FACTORS           	-	164	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=164.RAW
SUBJECT_SAMPLE_FACTORS           	-	165	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=165.RAW
SUBJECT_SAMPLE_FACTORS           	-	166	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=166.RAW
SUBJECT_SAMPLE_FACTORS           	-	167	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=167.RAW
SUBJECT_SAMPLE_FACTORS           	-	168	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=168.RAW
SUBJECT_SAMPLE_FACTORS           	-	169	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=169.RAW
SUBJECT_SAMPLE_FACTORS           	-	170	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=170.RAW
SUBJECT_SAMPLE_FACTORS           	-	171	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=171.RAW
SUBJECT_SAMPLE_FACTORS           	-	172	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=172.RAW
SUBJECT_SAMPLE_FACTORS           	-	173	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=173.RAW
SUBJECT_SAMPLE_FACTORS           	-	174	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=174.RAW
SUBJECT_SAMPLE_FACTORS           	-	175	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=175.RAW
SUBJECT_SAMPLE_FACTORS           	-	176	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=176.RAW
SUBJECT_SAMPLE_FACTORS           	-	177	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=177.RAW
SUBJECT_SAMPLE_FACTORS           	-	178	Fiber:Mix | Timepoint:30 | Sex:M	RAW_FILE_NAME=178.RAW
SUBJECT_SAMPLE_FACTORS           	-	179	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=179.RAW
SUBJECT_SAMPLE_FACTORS           	-	180	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=180.RAW
SUBJECT_SAMPLE_FACTORS           	-	181	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=181.RAW
SUBJECT_SAMPLE_FACTORS           	-	182	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=182.RAW
SUBJECT_SAMPLE_FACTORS           	-	183	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=183.RAW
SUBJECT_SAMPLE_FACTORS           	-	184	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=184.RAW
SUBJECT_SAMPLE_FACTORS           	-	185	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=185.RAW
SUBJECT_SAMPLE_FACTORS           	-	186	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=186.RAW
SUBJECT_SAMPLE_FACTORS           	-	188	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=188.RAW
SUBJECT_SAMPLE_FACTORS           	-	189	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=189.RAW
SUBJECT_SAMPLE_FACTORS           	-	190	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=190.RAW
SUBJECT_SAMPLE_FACTORS           	-	191	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=191.RAW
SUBJECT_SAMPLE_FACTORS           	-	192	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=192.RAW
SUBJECT_SAMPLE_FACTORS           	-	193	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=193.RAW
SUBJECT_SAMPLE_FACTORS           	-	194	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=194.RAW
SUBJECT_SAMPLE_FACTORS           	-	195	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=195.RAW
SUBJECT_SAMPLE_FACTORS           	-	197	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=197.RAW
SUBJECT_SAMPLE_FACTORS           	-	198	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=198.RAW
SUBJECT_SAMPLE_FACTORS           	-	199	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=199.RAW
SUBJECT_SAMPLE_FACTORS           	-	201	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=201.RAW
SUBJECT_SAMPLE_FACTORS           	-	203	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=203.RAW
SUBJECT_SAMPLE_FACTORS           	-	204	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=204.RAW
SUBJECT_SAMPLE_FACTORS           	-	205	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=205.RAW
SUBJECT_SAMPLE_FACTORS           	-	206	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=206.RAW
SUBJECT_SAMPLE_FACTORS           	-	207	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=207.RAW
SUBJECT_SAMPLE_FACTORS           	-	208	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=208.RAW
SUBJECT_SAMPLE_FACTORS           	-	209	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=209.RAW
SUBJECT_SAMPLE_FACTORS           	-	210	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=210.RAW
SUBJECT_SAMPLE_FACTORS           	-	211	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=211.RAW
SUBJECT_SAMPLE_FACTORS           	-	213	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=213.RAW
SUBJECT_SAMPLE_FACTORS           	-	214	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=214.RAW
SUBJECT_SAMPLE_FACTORS           	-	215	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=215.RAW
SUBJECT_SAMPLE_FACTORS           	-	216	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=216.RAW
SUBJECT_SAMPLE_FACTORS           	-	217	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=217.RAW
SUBJECT_SAMPLE_FACTORS           	-	218	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=218.RAW
SUBJECT_SAMPLE_FACTORS           	-	219	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=219.RAW
SUBJECT_SAMPLE_FACTORS           	-	220	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=220.RAW
SUBJECT_SAMPLE_FACTORS           	-	221	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=221.RAW
SUBJECT_SAMPLE_FACTORS           	-	222	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=222.RAW
SUBJECT_SAMPLE_FACTORS           	-	223	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=223.RAW
SUBJECT_SAMPLE_FACTORS           	-	224	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=224.RAW
SUBJECT_SAMPLE_FACTORS           	-	225	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=225.RAW
SUBJECT_SAMPLE_FACTORS           	-	226	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=226.RAW
SUBJECT_SAMPLE_FACTORS           	-	227	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=227.RAW
SUBJECT_SAMPLE_FACTORS           	-	228	Fiber:Arabinoxylan | Timepoint:10 | Sex:M	RAW_FILE_NAME=228.RAW
SUBJECT_SAMPLE_FACTORS           	-	229	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=229.RAW
SUBJECT_SAMPLE_FACTORS           	-	230	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=230.RAW
SUBJECT_SAMPLE_FACTORS           	-	231	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=231.RAW
SUBJECT_SAMPLE_FACTORS           	-	232	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=232.RAW
SUBJECT_SAMPLE_FACTORS           	-	233	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=233.RAW
SUBJECT_SAMPLE_FACTORS           	-	234	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=234.RAW
SUBJECT_SAMPLE_FACTORS           	-	235	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=235.RAW
SUBJECT_SAMPLE_FACTORS           	-	237	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=237.RAW
SUBJECT_SAMPLE_FACTORS           	-	238	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=238.RAW
SUBJECT_SAMPLE_FACTORS           	-	239	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=239.RAW
SUBJECT_SAMPLE_FACTORS           	-	240	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=240.RAW
SUBJECT_SAMPLE_FACTORS           	-	242	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=242.RAW
SUBJECT_SAMPLE_FACTORS           	-	243	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=243.RAW
SUBJECT_SAMPLE_FACTORS           	-	244	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=244.RAW
SUBJECT_SAMPLE_FACTORS           	-	245	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=245.RAW
SUBJECT_SAMPLE_FACTORS           	-	246	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=246.RAW
SUBJECT_SAMPLE_FACTORS           	-	248	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=248.RAW
SUBJECT_SAMPLE_FACTORS           	-	249	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=249.RAW
SUBJECT_SAMPLE_FACTORS           	-	250	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=250.RAW
SUBJECT_SAMPLE_FACTORS           	-	251	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=251.RAW
SUBJECT_SAMPLE_FACTORS           	-	252	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=252.RAW
SUBJECT_SAMPLE_FACTORS           	-	253	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=253.RAW
SUBJECT_SAMPLE_FACTORS           	-	254	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=254.RAW
SUBJECT_SAMPLE_FACTORS           	-	255	Fiber:Arabinoxylan | Timepoint:Washout Week 3 | Sex:M	RAW_FILE_NAME=255.RAW
SUBJECT_SAMPLE_FACTORS           	-	256	Fiber:Arabinoxylan | Timepoint:Week2 2 | Sex:M	RAW_FILE_NAME=256.RAW
SUBJECT_SAMPLE_FACTORS           	-	257	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=257.RAW
SUBJECT_SAMPLE_FACTORS           	-	258	Fiber:Mix | Timepoint:? | Sex:F	RAW_FILE_NAME=258.RAW
SUBJECT_SAMPLE_FACTORS           	-	259	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=259.RAW
SUBJECT_SAMPLE_FACTORS           	-	260	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=260.RAW
SUBJECT_SAMPLE_FACTORS           	-	261	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=261.RAW
SUBJECT_SAMPLE_FACTORS           	-	262	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=262.RAW
SUBJECT_SAMPLE_FACTORS           	-	263	Fiber:Arabinoxylan | Timepoint:Month 2 | Sex:M	RAW_FILE_NAME=263.RAW
SUBJECT_SAMPLE_FACTORS           	-	264	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=264.RAW
SUBJECT_SAMPLE_FACTORS           	-	265	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=265.RAW
SUBJECT_SAMPLE_FACTORS           	-	266	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=266.RAW
SUBJECT_SAMPLE_FACTORS           	-	267	Fiber:Mix | Timepoint:10 | Sex:F	RAW_FILE_NAME=267.RAW
SUBJECT_SAMPLE_FACTORS           	-	268	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=268.RAW
SUBJECT_SAMPLE_FACTORS           	-	269	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=269.RAW
SUBJECT_SAMPLE_FACTORS           	-	270	Fiber:Mix | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=270.RAW
SUBJECT_SAMPLE_FACTORS           	-	271	Fiber:Arabinoxylan | Timepoint:Month 3 | Sex:M	RAW_FILE_NAME=271.RAW
SUBJECT_SAMPLE_FACTORS           	-	272	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=272.RAW
SUBJECT_SAMPLE_FACTORS           	-	273	Fiber:Arabinoxylan | Timepoint:Month 3 | Sex:M	RAW_FILE_NAME=273.RAW
SUBJECT_SAMPLE_FACTORS           	-	274	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=274.RAW
SUBJECT_SAMPLE_FACTORS           	-	275	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=275.RAW
SUBJECT_SAMPLE_FACTORS           	-	276	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=276.RAW
SUBJECT_SAMPLE_FACTORS           	-	277	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=277.RAW
SUBJECT_SAMPLE_FACTORS           	-	278	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=278.RAW
SUBJECT_SAMPLE_FACTORS           	-	279	Fiber:Arabinoxylan | Timepoint:Month 1 | Sex:M	RAW_FILE_NAME=279.RAW
SUBJECT_SAMPLE_FACTORS           	-	280	Fiber:Inulin | Timepoint:Washout Week 3 | Sex:M	RAW_FILE_NAME=280.RAW
SUBJECT_SAMPLE_FACTORS           	-	281	Fiber:Inulin | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=281.RAW
SUBJECT_SAMPLE_FACTORS           	-	282	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=282.RAW
SUBJECT_SAMPLE_FACTORS           	-	283	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=283.RAW
SUBJECT_SAMPLE_FACTORS           	-	284	Fiber:Arabinoxylan | Timepoint:30 | Sex:F	RAW_FILE_NAME=284.RAW
SUBJECT_SAMPLE_FACTORS           	-	285	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=285.RAW
SUBJECT_SAMPLE_FACTORS           	-	286	Fiber:Arabinoxylan | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=286.RAW
SUBJECT_SAMPLE_FACTORS           	-	287	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=287.RAW
SUBJECT_SAMPLE_FACTORS           	-	288	Fiber:Mix | Timepoint:30 | Sex:M	RAW_FILE_NAME=288.RAW
SUBJECT_SAMPLE_FACTORS           	-	289	Fiber:Inulin | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=289.RAW
SUBJECT_SAMPLE_FACTORS           	-	290	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=290.RAW
SUBJECT_SAMPLE_FACTORS           	-	291	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=291.RAW
SUBJECT_SAMPLE_FACTORS           	-	292	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=292.RAW
SUBJECT_SAMPLE_FACTORS           	-	293	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=293.RAW
SUBJECT_SAMPLE_FACTORS           	-	294	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=294.RAW
SUBJECT_SAMPLE_FACTORS           	-	295	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=295.RAW
SUBJECT_SAMPLE_FACTORS           	-	296	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=296.RAW
SUBJECT_SAMPLE_FACTORS           	-	297	Fiber:Arabinoxylan | Timepoint:10 | Sex:F	RAW_FILE_NAME=297.RAW
SUBJECT_SAMPLE_FACTORS           	-	298	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=298.RAW
SUBJECT_SAMPLE_FACTORS           	-	299	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=299.RAW
SUBJECT_SAMPLE_FACTORS           	-	300	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=300.RAW
SUBJECT_SAMPLE_FACTORS           	-	301	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=301.RAW
SUBJECT_SAMPLE_FACTORS           	-	303	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=303.RAW
SUBJECT_SAMPLE_FACTORS           	-	304	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=304.RAW
SUBJECT_SAMPLE_FACTORS           	-	305	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=305.RAW
SUBJECT_SAMPLE_FACTORS           	-	306	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=306.RAW
SUBJECT_SAMPLE_FACTORS           	-	307	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=307.RAW
SUBJECT_SAMPLE_FACTORS           	-	308	Fiber:Inulin | Timepoint:20 | Sex:M	RAW_FILE_NAME=308.RAW
SUBJECT_SAMPLE_FACTORS           	-	309	Fiber:Inulin | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=309.RAW
SUBJECT_SAMPLE_FACTORS           	-	310	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=310.RAW
SUBJECT_SAMPLE_FACTORS           	-	311	Fiber:Arabinoxylan | Timepoint:20 | Sex:M	RAW_FILE_NAME=311.RAW
SUBJECT_SAMPLE_FACTORS           	-	312	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=312.RAW
SUBJECT_SAMPLE_FACTORS           	-	313	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=313.RAW
SUBJECT_SAMPLE_FACTORS           	-	314	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=314.RAW
SUBJECT_SAMPLE_FACTORS           	-	315	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=315.RAW
SUBJECT_SAMPLE_FACTORS           	-	316	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=316.RAW
SUBJECT_SAMPLE_FACTORS           	-	317	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=317.RAW
SUBJECT_SAMPLE_FACTORS           	-	319	Fiber:Mix | Timepoint:20 | Sex:M	RAW_FILE_NAME=319.RAW
SUBJECT_SAMPLE_FACTORS           	-	320	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=320.RAW
SUBJECT_SAMPLE_FACTORS           	-	321	Fiber:Mix | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=321.RAW
SUBJECT_SAMPLE_FACTORS           	-	322	Fiber:Mix | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=322.RAW
SUBJECT_SAMPLE_FACTORS           	-	323	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=323.RAW
SUBJECT_SAMPLE_FACTORS           	-	324	Fiber:Mix | Timepoint:Washout Week 3 | Sex:M	RAW_FILE_NAME=324.RAW
SUBJECT_SAMPLE_FACTORS           	-	325	Fiber:Arabinoxylan | Timepoint:Month 2 | Sex:M	RAW_FILE_NAME=325.RAW
SUBJECT_SAMPLE_FACTORS           	-	326	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=326.RAW
SUBJECT_SAMPLE_FACTORS           	-	327	Fiber:Arabinoxylan | Timepoint:20 | Sex:F	RAW_FILE_NAME=327.RAW
SUBJECT_SAMPLE_FACTORS           	-	328	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=328.RAW
SUBJECT_SAMPLE_FACTORS           	-	329	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=329.RAW
SUBJECT_SAMPLE_FACTORS           	-	330	Fiber:Inulin | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=330.RAW
SUBJECT_SAMPLE_FACTORS           	-	331	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=331.RAW
SUBJECT_SAMPLE_FACTORS           	-	332	Fiber:Mix | Timepoint:30 | Sex:F	RAW_FILE_NAME=332.RAW
SUBJECT_SAMPLE_FACTORS           	-	333	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=333.RAW
SUBJECT_SAMPLE_FACTORS           	-	334	Fiber:Inulin | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=334.RAW
SUBJECT_SAMPLE_FACTORS           	-	335	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=335.RAW
SUBJECT_SAMPLE_FACTORS           	-	336	Fiber:Mix | Timepoint:20 | Sex:F	RAW_FILE_NAME=336.RAW
SUBJECT_SAMPLE_FACTORS           	-	337	Fiber:Inulin | Timepoint:20 | Sex:F	RAW_FILE_NAME=337.RAW
SUBJECT_SAMPLE_FACTORS           	-	338	Fiber:Mix | Timepoint:Washout D3 | Sex:M	RAW_FILE_NAME=338.RAW
SUBJECT_SAMPLE_FACTORS           	-	339	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=339.RAW
SUBJECT_SAMPLE_FACTORS           	-	340	Fiber:Inulin | Timepoint:Washout D3 | Sex:F	RAW_FILE_NAME=340.RAW
SUBJECT_SAMPLE_FACTORS           	-	341	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=341.RAW
SUBJECT_SAMPLE_FACTORS           	-	342	Fiber:Inulin | Timepoint:10 | Sex:M	RAW_FILE_NAME=342.RAW
SUBJECT_SAMPLE_FACTORS           	-	343	Fiber:Arabinoxylan | Timepoint:30 | Sex:M	RAW_FILE_NAME=343.RAW
SUBJECT_SAMPLE_FACTORS           	-	345	Fiber:Arabinoxylan | Timepoint:Baseline | Sex:M	RAW_FILE_NAME=345.RAW
SUBJECT_SAMPLE_FACTORS           	-	346	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=346.RAW
SUBJECT_SAMPLE_FACTORS           	-	347	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=347.RAW
SUBJECT_SAMPLE_FACTORS           	-	348	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=348.RAW
SUBJECT_SAMPLE_FACTORS           	-	349	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=349.RAW
SUBJECT_SAMPLE_FACTORS           	-	350	Fiber:Inulin | Timepoint:30 | Sex:M	RAW_FILE_NAME=350.RAW
SUBJECT_SAMPLE_FACTORS           	-	351	Fiber:Mix | Timepoint:10 | Sex:M	RAW_FILE_NAME=351.RAW
SUBJECT_SAMPLE_FACTORS           	-	352	Fiber:Inulin | Timepoint:10 | Sex:F	RAW_FILE_NAME=352.RAW
SUBJECT_SAMPLE_FACTORS           	-	354	Fiber:Arabinoxylan | Timepoint:Washout D10 | Sex:M	RAW_FILE_NAME=354.RAW
SUBJECT_SAMPLE_FACTORS           	-	355	Fiber:Inulin | Timepoint:End Washout | Sex:M	RAW_FILE_NAME=355.RAW
SUBJECT_SAMPLE_FACTORS           	-	356	Fiber:Mix | Timepoint:Baseline | Sex:F	RAW_FILE_NAME=356.RAW
SUBJECT_SAMPLE_FACTORS           	-	357	Fiber:Mix | Timepoint:Washout D10 | Sex:F	RAW_FILE_NAME=357.RAW
SUBJECT_SAMPLE_FACTORS           	-	358	Fiber:Inulin | Timepoint:30 | Sex:F	RAW_FILE_NAME=358.RAW
#COLLECTION
CO:COLLECTION_SUMMARY            	The study is a longitudinal, randomized crossover design in which 18 consented
CO:COLLECTION_SUMMARY            	participants (8 men and 10 women) had their diets periodically supplemented with
CO:COLLECTION_SUMMARY            	two fibers, arabinoxylan (AX) and long-chain inulin, and a mixture of fibers
CO:COLLECTION_SUMMARY            	consisting of equal parts AX, LCI, acacia gum, glucomannans, and resistant
CO:COLLECTION_SUMMARY            	starch. Participants were randomized to consume either AX or LCI first, and the
CO:COLLECTION_SUMMARY            	mixed fibers were always administered last. For each of the fiber cycles, blood,
CO:COLLECTION_SUMMARY            	urine and stool samples were collected at seven timepoints: baseline, end of
CO:COLLECTION_SUMMARY            	week one, end of week two, end of week three, day 3 after end of supplementation
CO:COLLECTION_SUMMARY            	and day 10 after end of supplementation. Blood was fractionated into plasma,
CO:COLLECTION_SUMMARY            	serum and peripheral blood mononucleotide cells (PBMCs). Metabolomics was
CO:COLLECTION_SUMMARY            	performed on the plasma fraction of the blood. Once all samples were in the
CO:COLLECTION_SUMMARY            	correct aliquots, they were stored at -80C. Samples were only thawed when
CO:COLLECTION_SUMMARY            	prepared for analysis for each of the respective omics assay which were all
CO:COLLECTION_SUMMARY            	performed within 5 years of collecting the samples.
CO:SAMPLE_TYPE                   	Blood (plasma)
#TREATMENT
TR:TREATMENT_SUMMARY             	Participants went through 3 cycles of fiber supplementation, each cycle was
TR:TREATMENT_SUMMARY             	three weeks long with weekly increasing doses of 10 g/day during the first week,
TR:TREATMENT_SUMMARY             	20g/day during the second week and 30 g/day during the third week. Randomized
TR:TREATMENT_SUMMARY             	for the first two cycles, fibers tested were chicory inulin (99%>5 dp; range
TR:TREATMENT_SUMMARY             	2-60dp; average >23 dp) and arabinoxylan (psyllium husks powder Now Foods) and a
TR:TREATMENT_SUMMARY             	mix of 5 fibers during the third cycle. The fiber mix included equal amounts of
TR:TREATMENT_SUMMARY             	inulin, arabinoxylan, glucomannan (Now Foods), resistant starch (Hi Maize from
TR:TREATMENT_SUMMARY             	Honeyville), and acacia fiber (Now Foods). Washout period between the cycles was
TR:TREATMENT_SUMMARY             	from 6-10 weeks. Fiber was provided in 10 g sachets and participants were
TR:TREATMENT_SUMMARY             	instructed to resuspend content of the sachet in at least 8 oz of water and
TR:TREATMENT_SUMMARY             	drink one with breakfast for the first week, one with breakfast and one with
TR:TREATMENT_SUMMARY             	dinner during the second week, and one with each meal (breakfast, lunch and
TR:TREATMENT_SUMMARY             	dinner) during the third week.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	We performed an untargeted metabolomics using a platform, previously described
SP:SAMPLEPREP_SUMMARY            	in Contrepois et al., 2015 (Contrepois et al., 2015) to profile plasma extracted
SP:SAMPLEPREP_SUMMARY            	metabolites. Samples were thawed and 100 μL of plasma was transferred into a
SP:SAMPLEPREP_SUMMARY            	2mL Protein Lobind Eppendorf tube. In order to precipitate and remove proteins,
SP:SAMPLEPREP_SUMMARY            	400 μL of 1:1:1 methanol:acetonitrile:acetone solution, including 17 internal
SP:SAMPLEPREP_SUMMARY            	standards to control for extraction efficiency and evaluate LC-MS performance,
SP:SAMPLEPREP_SUMMARY            	was added to each plasma sample while on a cold plate. Samples were placed on
SP:SAMPLEPREP_SUMMARY            	the vortex shaker for 15 minutes at 4C then placed at -20C for two hours to
SP:SAMPLEPREP_SUMMARY            	allow for sufficient protein precipitation. Samples were centrifuged at 10,000
SP:SAMPLEPREP_SUMMARY            	rpm for 10 min at 4C and the supernatant (metabolite extract) from each sample
SP:SAMPLEPREP_SUMMARY            	was carefully removed and placed in a new 2mL Protein Lobind Eppendorf tube.
SP:SAMPLEPREP_SUMMARY            	Samples were placed in the turbovap, evaporated to dryness under nitrogen and
SP:SAMPLEPREP_SUMMARY            	stored at -80C. Before analysis on the MS, samples were reconstituted in 100 μL
SP:SAMPLEPREP_SUMMARY            	1:1 methanol:water solution and vortexed for 30s, placed in a bath sonicator for
SP:SAMPLEPREP_SUMMARY            	30s and incubated on ice for 30s. This process was repeated 3 times for all
SP:SAMPLEPREP_SUMMARY            	samples and were centrifuged at 10,000 rpm for 10 min at 4C. The supernatant of
SP:SAMPLEPREP_SUMMARY            	each of these was then transferred to MS tubes and stored at -20C until ran on
SP:SAMPLEPREP_SUMMARY            	the mass spectrometer.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	HILIC experiments were performed using a ZIC-HILIC column 2.1x100 mm, 3.5μm,
CH:CHROMATOGRAPHY_SUMMARY        	200Å (Merck Millipore) and mobile phase solvents consisting of 10mM ammonium
CH:CHROMATOGRAPHY_SUMMARY        	acetate in 50/50 acetonitrile/water (A) and 10 mM ammonium acetate in 95/5
CH:CHROMATOGRAPHY_SUMMARY        	acetonitrile/water (B).(Contrepois et al., 2015)
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000 RS
CH:COLUMN_NAME                   	SeQuant ZIC-HILIC (100 x 2.1mm, 3.5um)
CH:FLOW_RATE                     	.5 ml/min
CH:COLUMN_TEMPERATURE            	40
CH:SOLVENT_A                     	10mM ammonium acetate in 50/50 acetonitrile/water
CH:SOLVENT_B                     	10 mM ammonium acetate in 95/5 acetonitrile/water
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Plus Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Raw data were imported into Progenesis QI 2.3 software (Water, Milford, MA, USA)
MS:MS_COMMENTS                   	to align and quantify chromatographic peaks. Data from all 4 acquisition modes
MS:MS_COMMENTS                   	(HILIC positive, HILIC negative, RPLC positive, RPLC negative) were processed
MS:MS_COMMENTS                   	independently. Using in house R code, we 1) removed noise, 2) imputed data and
MS:MS_COMMENTS                   	3) adjusted for MS drift with time using the LOESS normalization method on
MS:MS_COMMENTS                   	pooled QCs injected every 10 injections in the sequence. We used MetID and our
MS:MS_COMMENTS                   	MS/MS data to identify 12740 metabolites with confidence levels ranging from
MS:MS_COMMENTS                   	1-3, where 1 matches MS/MS, retention time and m/z from standards on our
MS:MS_COMMENTS                   	platform (843 metabolites), 2 has MS/MS and m/z matches from a database (395
MS:MS_COMMENTS                   	metabolites), and 3 matches the m/z of a database (11,502).
MS:MS_RESULTS_FILE               	ST002112_AN004115_Results.txt	UNITS:Area	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END