#METABOLOMICS WORKBENCH riverup_20230405_230208 DATATRACK_ID:3846 STUDY_ID:ST002542 ANALYSIS_ID:AN004188 PROJECT_ID:PR001637 VERSION 1 CREATED_ON 10-30-2024 #PROJECT PR:PROJECT_TITLE The metabolomics analysis of Methionine restriction PR:PROJECT_TYPE targeted metabolomics data PR:PROJECT_SUMMARY Methionine restriction (MR) provides metabolic benefits in many organisms. PR:PROJECT_SUMMARY However, mechanisms underlying the MR-induced effect remain incompletely PR:PROJECT_SUMMARY understood. Here, we show in the budding yeast S. cerevisiae that MR relays a PR:PROJECT_SUMMARY signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic PR:PROJECT_SUMMARY mitochondria to nitrogenic anabolism.In particular, decreases in cellular SAM PR:PROJECT_SUMMARY constrain lipoate metabolism and protein lipoylation required for the operation PR:PROJECT_SUMMARY of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete PR:PROJECT_SUMMARY glucose oxidation with an exit of acetyl-CoA and alpha-ketoglutarate from the PR:PROJECT_SUMMARY TCA cycle to the syntheses of amino acids, such as arginine and leucine. This PR:PROJECT_SUMMARY mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness PR:PROJECT_SUMMARY through the coordination of mitochondrial fuel metabolism with the nitrogenic PR:PROJECT_SUMMARY synthesis of amino acids. PR:INSTITUTE Zhejiang University PR:DEPARTMENT Life Sciences Institute PR:LAST_NAME Cunqi PR:FIRST_NAME Ye PR:ADDRESS 866 Yuhangtang Rd, Hangzhou 310058, P.R. China PR:EMAIL yecunqi@zju.edu.cn PR:PHONE 15267181160 PR:DOI http://dx.doi.org/10.21228/M83M7P #STUDY ST:STUDY_TITLE Methionine restriction constrains lipoylation and activates mitochondria for ST:STUDY_TITLE nitrogenic synthesis of amino acids (Part 2) ST:STUDY_SUMMARY Methionine restriction (MR) provides metabolic benefits in many organisms. ST:STUDY_SUMMARY However, mechanisms underlying the MR-induced effect remain incompletely ST:STUDY_SUMMARY understood. Here, we show in the budding yeast S. cerevisiae that MR relays a ST:STUDY_SUMMARY signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic ST:STUDY_SUMMARY mitochondria to nitrogenic anabolism. In particular, decreases in cellular SAM ST:STUDY_SUMMARY constrain lipoate metabolism and protein lipoylation required for the operation ST:STUDY_SUMMARY of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete ST:STUDY_SUMMARY glucose oxidation with an exit of acetyl-CoA and alpha-ketoglutarate from the ST:STUDY_SUMMARY TCA cycle to the syntheses of amino acids, such as arginine and leucine. This ST:STUDY_SUMMARY mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness ST:STUDY_SUMMARY through the coordination of mitochondrial fuel metabolism with the nitrogenic ST:STUDY_SUMMARY synthesis of amino acids. ST:INSTITUTE ZheJiang University ST:DEPARTMENT Life Sciences Institute ST:LAST_NAME Cunqi ST:FIRST_NAME Ye ST:ADDRESS 866 Yuhangtang Rd, Hangzhou 310058, P.R. China ST:EMAIL yecunqi@zju.edu.cn ST:PHONE 15267181160 ST:SUBMIT_DATE 2023-04-05 #SUBJECT SU:SUBJECT_TYPE Yeast SU:SUBJECT_SPECIES Saccharomyces cerevisiae SU:TAXONOMY_ID 4932 SU:GENOTYPE_STRAIN CEN.P.K #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - S1S2 0h_1 label:0h RAW_FILE_NAME=S1S2 0h_1 SUBJECT_SAMPLE_FACTORS - S1S2 0h_2 label:0h RAW_FILE_NAME=S1S2 0h_2 SUBJECT_SAMPLE_FACTORS - S1S2 0h _3 label:0h RAW_FILE_NAME=S1S2 0h _3 SUBJECT_SAMPLE_FACTORS - S1S2 15h_1 label:15h RAW_FILE_NAME=S1S2 15h_1 SUBJECT_SAMPLE_FACTORS - S1S2 15h_2 label:15h RAW_FILE_NAME=S1S2 15h_2 SUBJECT_SAMPLE_FACTORS - S1S2 15h_3 label:15h RAW_FILE_NAME=S1S2 15h_3 SUBJECT_SAMPLE_FACTORS - S1S2 15h_1+ label:15h+ RAW_FILE_NAME=S1S2 15h_1+ SUBJECT_SAMPLE_FACTORS - S1S2 15h_2+ label:15h+ RAW_FILE_NAME=S1S2 15h_2+ SUBJECT_SAMPLE_FACTORS - S1S2 15h_3+ label:15h+ RAW_FILE_NAME=S1S2 15h_3+ SUBJECT_SAMPLE_FACTORS - S1S2 2h_1 label:2h RAW_FILE_NAME=S1S2 2h_1 SUBJECT_SAMPLE_FACTORS - S1S2 2h_2 label:2h RAW_FILE_NAME=S1S2 2h_2 SUBJECT_SAMPLE_FACTORS - S1S2 2h_3 label:2h RAW_FILE_NAME=S1S2 2h_3 SUBJECT_SAMPLE_FACTORS - S1S2 2h_1+ label:2h+ RAW_FILE_NAME=S1S2 2h_1+ SUBJECT_SAMPLE_FACTORS - S1S2 2h_2+ label:2h+ RAW_FILE_NAME=S1S2 2h_2+ SUBJECT_SAMPLE_FACTORS - S1S2 2h_3+ label:2h+ RAW_FILE_NAME=S1S2 2h_3+ SUBJECT_SAMPLE_FACTORS - S1S2 4h_1 label:4h RAW_FILE_NAME=S1S2 4h_1 SUBJECT_SAMPLE_FACTORS - S1S2 4h_2 label:4h RAW_FILE_NAME=S1S2 4h_2 SUBJECT_SAMPLE_FACTORS - S1S2 4h_3 label:4h RAW_FILE_NAME=S1S2 4h_3 SUBJECT_SAMPLE_FACTORS - S1S2 4h_1+ label:4h+ RAW_FILE_NAME=S1S2 4h_1+ SUBJECT_SAMPLE_FACTORS - S1S2 4h_2+ label:4h+ RAW_FILE_NAME=S1S2 4h_2+ SUBJECT_SAMPLE_FACTORS - S1S2 4h_3+ label:4h+ RAW_FILE_NAME=S1S2 4h_3+ SUBJECT_SAMPLE_FACTORS - S1S2 6h_1 label:6h RAW_FILE_NAME=S1S2 6h_1 SUBJECT_SAMPLE_FACTORS - S1S2 6h_2 label:6h RAW_FILE_NAME=S1S2 6h_2 SUBJECT_SAMPLE_FACTORS - S1S2 6h_3 label:6h RAW_FILE_NAME=S1S2 6h_3 SUBJECT_SAMPLE_FACTORS - S1S2 6h_1+ label:6h+ RAW_FILE_NAME=S1S2 6h_1+ SUBJECT_SAMPLE_FACTORS - S1S2 6h_2+ label:6h+ RAW_FILE_NAME=S1S2 6h_2+ SUBJECT_SAMPLE_FACTORS - S1S2 6h_3+ label:6h+ RAW_FILE_NAME=S1S2 6h_3+ #COLLECTION CO:COLLECTION_SUMMARY Care was taken to quench cells quickly in -40â and maintain metabolites in CO:COLLECTION_SUMMARY acid to minimize oxidation CO:SAMPLE_TYPE Yeast cells #TREATMENT TR:TREATMENT_SUMMARY Mutant SAM1SAM2 DKO cells were cultured in SD medium with the supplements of SAM TR:TREATMENT_SUMMARY and growed to log phase, then cells were washed with normal SD medium and TR:TREATMENT_SUMMARY re-cultured in SD medium #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Briefly, equal OD units of cells were rapidly quenched to stop metabolism by SP:SAMPLEPREP_SUMMARY addition into 4 volumes of quenching buffer containing 60% methanol and 10 mM SP:SAMPLEPREP_SUMMARY Tricine, pH 7.4 that was pre-cooled to -40°C. 5 min after holding at -40°C, SP:SAMPLEPREP_SUMMARY cells were spun at 5,000 g for 3 min at 0°C, washed with the same buffer, and SP:SAMPLEPREP_SUMMARY then resuspended in 1 mL extraction buffer containing 75% ethanol and 0.5 mM SP:SAMPLEPREP_SUMMARY Tricine, pH 7.4. Intracellular metabolites were extracted by incubating at 75°C SP:SAMPLEPREP_SUMMARY for 3 min, followed by chilling on ice for 5 min. Samples were spun at 20,000 g SP:SAMPLEPREP_SUMMARY for 1 min to pellet cell debris, and 0.9 mL of the supernatant was transferred SP:SAMPLEPREP_SUMMARY to a new tube. After a second spin at 20,000 g for 10 min, 0.8 mL of the SP:SAMPLEPREP_SUMMARY supernatant was transferred to a new tube. Metabolites in the extraction buffer SP:SAMPLEPREP_SUMMARY were dried using a vacuum concentrator system (Labconco) and stored at -80°C SP:SAMPLEPREP_SUMMARY until analysis. Dried metabolite extracts were resuspended in 60% acetonitrile SP:SAMPLEPREP_SUMMARY for injection. #CHROMATOGRAPHY CH:INSTRUMENT_NAME Shimadzu 20AD CH:COLUMN_NAME Merck SeQuant ZIC-pHILIC (150 x 2.1mm,5um) CH:COLUMN_TEMPERATURE 45 CH:FLOW_GRADIENT 0.01 min 80% B, 20 min 20% B, 20.5 min 80% B, 34 min 80% B. CH:FLOW_RATE 0.15ml/min CH:SOLVENT_A 20 mM ammonium carbonate and 0.1% (v/v) ammonium hydroxide CH:SOLVENT_B acetonitrile CH:CHROMATOGRAPHY_TYPE HILIC #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 6500+ QTrap MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:MS_COMMENTS SCIEX OS MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak intensity MS_METABOLITE_DATA_START Samples S1S2 0h_1 S1S2 0h_2 S1S2 0h _3 S1S2 15h_1 S1S2 15h_2 S1S2 15h_3 S1S2 15h_1+ S1S2 15h_2+ S1S2 15h_3+ S1S2 2h_1 S1S2 2h_2 S1S2 2h_3 S1S2 2h_1+ S1S2 2h_2+ S1S2 2h_3+ S1S2 4h_1 S1S2 4h_2 S1S2 4h_3 S1S2 4h_1+ S1S2 4h_2+ S1S2 4h_3+ S1S2 6h_1 S1S2 6h_2 S1S2 6h_3 S1S2 6h_1+ S1S2 6h_2+ S1S2 6h_3+ Factors label:0h label:0h label:0h label:15h label:15h label:15h label:15h+ label:15h+ label:15h+ label:2h label:2h label:2h label:2h+ label:2h+ label:2h+ label:4h label:4h label:4h label:4h+ label:4h+ label:4h+ label:6h label:6h label:6h label:6h+ label:6h+ label:6h+ 13C-Alanine-1 13C-Arginine-1 2932.9005 4779.5979 5983.2110 72596.3944 25726.5272 31540.6617 114455.8032 100973.0646 31808.1741 6121.9273 8895.0311 5163.1819 42824.6592 8927.6346 14657.3494 5257.8519 8867.6083 14203.2118 19428.5564 25566.3539 25712.3897 47965.0028 72150.7600 58159.1714 88068.4761 48582.0519 38315.7527 13C-Aspartate-1 24189.1099 25731.6041 8461.6059 133885.8100 129018.7819 58582.6392 72470.4846 88083.1288 80465.6371 20299.8919 11720.9068 18600.5350 18066.3655 18553.1081 18566.7808 9558.4117 34768.8696 18410.6682 10259.2455 21053.4374 20823.5429 46826.4756 103256.8817 32254.0849 70713.7257 94711.0461 36506.7916 13C-Cystine-1 2559.4103 2061.0664 3801.5920 18316.9012 3697.0071 1628.9303 2908.3442 6566.3607 7302.1334 2576.4395 5905.6706 8305.7857 3778.6026 4469.9074 11277.0550 13715.0847 12933.9347 7597.0320 6154.0710 1751.0643 10017.8944 5419.8202 9515.7620 4069.3731 4085.8067 4634.6231 3995.9287 13C-Glutamic acid-1 17220.7097 18449.8738 24135.9418 1931.1741 3058.6197 2631.0450 9092.5422 8373.5318 14590.2431 7881.6860 26819.4935 4066.1378 24875.2927 9089.1498 9804.2194 10288.8869 7388.1312 4050.7963 8365.5342 14232.4024 5945.6215 2389.4258 4070.9681 8131.0811 13C-Glycine-1 13C-Histidine-1 264760.0652 204538.1474 272040.5593 103861.0028 111382.6083 91982.7029 34799.3643 57235.4002 143866.3202 228380.1264 184982.5136 474081.3293 294159.8154 378598.6487 335788.3218 267926.8327 223631.0333 331829.8571 219433.9879 215870.0617 204736.0282 192662.4716 89982.8853 106871.9579 163104.0268 156195.2584 222736.1524 13C-Iso Leucine-1 2391.8495 1673.8133 13C lysine 2870.2260 1674.2772 2152.6739 13C-Lysine-1 1224346.6390 849673.1753 346699.9941 721181.5093 303027.4937 298014.6576 672949.6686 533855.2842 545264.9008 1166916.9600 676793.3056 1071659.3780 1176751.1410 812105.8531 767537.7058 1186003.0060 693416.1961 569289.3796 769338.3417 160432.4231 723764.7733 193391.4210 346489.4345 731933.3622 879552.5137 13C-Methionine-1 497538.4289 466932.0020 513342.0607 226736.3032 342831.9579 310062.1048 433427.2144 563384.3949 556214.6558 400532.5368 337365.7829 472990.0384 440160.8254 504451.4818 437170.8473 431807.5341 451260.5331 384992.2878 322861.8354 331897.1989 478633.9853 284495.5603 299353.2288 276333.0538 521139.8083 451194.8919 274330.2157 13 C phenylalanine 6001.6352 5337.6403 7325.6922 3321.6624 12374.8959 5995.6119 5335.6767 7852.5058 12513.1493 3875.2637 9283.8170 4462.4390 8101.5299 5675.4878 13044.6876 9557.4679 8258.2121 5697.8127 7870.9808 8900.7059 8353.7211 4106.2098 2235.3209 2636.8611 1955.5501 7405.5554 13C-Phenylalanine-1 6186.1423 4646.1203 5644.2760 1731.0729 2369.2971 4336.3692 3848.7379 1771.3772 3338.3211 5539.5895 8970.2750 2228.2416 9376.4942 2721.6502 4850.5771 2651.1731 5306.3066 6107.7724 3558.0077 3904.8323 3146.5889 6823.2955 7236.7410 5517.5473 13C-Proline1 38119.0861 68225.8470 90705.2188 32720.0936 32380.1053 25984.3300 122829.3689 136038.5987 116803.6078 48434.5982 37057.6540 54950.7795 58018.9778 75719.0462 70237.9264 50945.2677 63710.9326 45633.6005 53647.4888 39130.2335 38952.6641 41503.2813 37752.2141 30520.1892 35454.9023 38316.9511 53020.0887 13C-Serine-1 13C-Threonine-1 3415.8050 10140.9361 3342.0705 5540.7915 12643.5199 8172.5087 4959.9405 2361.9541 6460.1649 2413.2819 3266.2873 10930.1179 2583.2613 6657.5798 3993.0682 2066.9518 4293.3165 2815.7987 6900.7925 1524.8534 1483.5984 3733.8356 2274.4426 2179.2616 1742.3924 13C tyrosine 2743868.2200 2636106.9490 3332467.2450 559324.5509 1625831.8650 1374713.1030 1473350.6290 2102300.5720 2053217.0440 2225757.9160 1589236.2020 3208611.3680 822856.2822 2631952.1610 1359247.9240 2526133.2660 2155102.2700 1397304.6020 896737.4518 1293725.5160 2266491.4070 1300784.5370 911843.2617 608911.5788 2804524.5810 2778868.5580 600529.5816 13C-Tyrosine 205286215.9000 176300231.8000 247782985.2000 35840968.3400 105013581.6000 96942056.0600 104772787.8000 142255424.3000 131636458.5000 160618755.2000 106051498.9000 242225510.0000 58284630.1100 194935424.9000 87086858.6200 177189904.9000 150923492.6000 96202916.9300 57921716.7200 90498932.5100 157082168.6000 87511178.6800 51963099.5400 45114692.2800 195125538.6000 186914223.0000 39962685.7700 13C valine-1 13C-Valine-1 1690.9318 1553.0247 1-Methyladenosine 3227738.7950 4333167.8230 4303449.1350 35046118.9200 22341862.4300 20838894.4300 27699596.0300 53831450.1500 45063231.1900 3495163.8930 4127007.1220 2807203.3750 3978936.3210 4568556.0860 4168437.5330 12359548.1900 14015903.8800 14424114.0100 4446474.5070 5210348.7480 4197155.2180 26183147.0800 25243578.0100 20998425.9600 4334821.5730 3930632.5740 5042258.1210 1-Methylhistidine 24110.5419 45749.5760 66845.4404 47956.2791 44707.3685 64675.2137 43058.9532 61489.4615 48180.6478 42635.5064 44273.9976 35497.9557 48402.2740 37515.3830 24137.3576 176822.5891 114790.5328 115190.5536 27338.2146 53484.3362 50130.3543 132632.3348 115354.4966 100522.8357 21579.9749 71568.2514 18592.1176 1-Methylnicotinamide 10577211.2900 13805071.0600 20102777.8600 4082787.4890 3690039.7720 4304321.2440 18514019.2700 24996910.2500 21837384.7400 1077527.1800 946488.0026 986119.8449 12206154.9900 12275101.6200 22589118.9400 3287673.4700 3654042.6570 3435085.5240 5390753.2190 11392554.7300 13752651.2700 6152607.5060 4791364.9920 4045192.2050 10933628.2100 12872384.5800 12515764.7000 3_5-Diiodothyronine 9089.0665 9921.2919 7212.0590 6878.0991 3819.0874 2404.7148 14411.3903 13196.0125 19768.3823 1653.4141 9089.0804 15080.5684 7368.4851 6419.2365 6374.4933 11200.0151 5178.2748 11654.4028 1915.4565 8837.8833 4804.1271 27267.1318 10773.3264 7123.1102 10242.9456 17698.1808 5385.6356 5-Methoxytryptophan 10832.5742 9669.2414 5205.6073 12707.7456 13160.3158 1441.1550 14740.0801 7739.6033 7776.5735 17699.1552 42463.2049 18461.5924 22762.9241 19184.2774 19608.8850 29991.6075 8922.8764 32106.2856 10945.8640 13657.9610 4296.2282 14357.8125 21960.1890 19222.2918 7932.9916 18348.6936 18198.5665 5-Methyltetrahydrofolic acid 31270.9099 15796.9446 42298.1884 26599.7605 34027.9088 82627.0754 29142.7987 25820.7857 16428.9288 19058.3602 29627.4329 15569.4919 48374.8705 19029.5209 45047.6726 31625.5714 38428.0852 16861.8930 38245.4759 23314.1995 16935.8279 24784.7373 24145.0740 17085.4462 24372.2734 9286.3781 42925.7701 5^-Methylthioadenosine 1910431667.0000 2372076666.0000 2133835819.0000 773036643.5000 453692287.4000 416110834.1000 2921629637.0000 3646748399.0000 3188175568.0000 909885064.2000 1064684375.0000 781199702.3000 4532253994.0000 2954009009.0000 3734841788.0000 1459418615.0000 1065786487.0000 1353087527.0000 3098625034.0000 3464660058.0000 2899535612.0000 1260895538.0000 1360692738.0000 1474461615.0000 1513485080.0000 1386373511.0000 2533425484.0000 5-Thymidylic acid 66917.1998 45199.0607 76514.0750 23254.6694 38819.0184 25199.4878 26641.4330 17577.3535 25887.5197 48234.9650 38280.0883 60600.0432 33616.8084 43555.6038 41770.9258 29486.1083 43494.3064 39563.5099 46174.7883 42507.6626 40987.5587 30092.6114 24172.0737 27215.4723 45143.8627 57058.5855 21715.8533 7-Methylguanosine 126027.6956 142098.3776 141560.2644 180943.7429 145437.1258 137980.4731 1776891.7510 3156486.3730 2523517.0280 157550.1329 121351.4854 112236.7610 105750.9129 102544.5933 147309.6594 616315.0758 518983.3109 565246.4407 87183.1067 121965.4679 154598.9773 571641.4166 592940.2909 372122.9372 181694.5300 176741.9440 131695.5408 Acetoacetyl-CoA 8610.6423 6219.0995 2152.6418 6218.7010 3587.6154 2389.2661 4556.5882 10524.1456 5262.0533 7653.8812 7893.2912 4824.9875 7414.7436 3669.5459 4303.9024 6697.1269 5379.2267 3940.3036 2391.4878 7653.7567 3587.7574 5741.4580 4783.6879 1926.9350 5508.8684 Acetyl-CoA 3753753.1220 5513711.0320 4631872.8910 2729850.6930 1624057.2490 2301926.3740 1980521.2540 4123537.8980 3292304.4590 3518199.8730 5454926.6120 3345782.3250 5162706.6150 4907318.8780 3710747.4730 3922427.6530 4193966.3060 3359876.3240 4007296.1700 4269443.2210 4642612.7820 4532304.2520 3656470.8760 3415367.3250 3730310.2390 3349311.6270 3020185.5040 Adenine 165203334.0000 227531996.6000 225921055.4000 40567619.1600 36492732.7500 30758525.1600 223855255.4000 249588746.2000 218274672.6000 107731507.2000 85387558.6300 75970681.9700 294489416.0000 319579864.4000 321415681.5000 136464126.4000 78473965.0000 128972918.5000 204263378.9000 278116170.3000 250902088.4000 67815490.6100 61893989.4700 45798134.6800 92166311.6100 134032156.6000 166653436.1000 Adenosine 15508724.4600 19012687.3900 26368016.8600 11158950.3100 11474290.6500 11720790.4700 13429973.3000 12123040.4200 13370312.0200 15520670.7500 13512980.1500 13355196.2000 21139870.1500 19183865.7800 24361869.8800 305573627.6000 29833664.2700 25258590.2300 18695364.2000 53086798.1300 19309789.8900 15388704.0400 13713503.8000 13163852.1600 15389612.6200 14688568.0400 11361496.9600 Adenosine monophosphate 18606544.5200 25484729.7200 30034277.8900 40545446.0900 29859504.0100 31684173.2000 17868718.3100 21687623.0900 19941300.3400 18591601.6800 25099581.7000 23051614.4200 55711050.7300 44098851.2700 70356415.3100 62568539.8800 48511293.6500 63907158.2400 65949417.6000 74544092.7600 46599957.1900 35714564.2100 43394078.3200 44526170.6700 24214931.8700 30378347.1200 27820365.4300 AICAR 37533.9095 47782.0451 54489.8983 36647.2234 51752.4825 38181.9184 32887.5941 59568.8364 20165.1403 55907.5736 73605.8357 69913.1927 73073.7286 51267.1242 62959.2663 50358.6581 64620.9740 78290.3474 71199.9052 97963.0005 79001.7631 75736.5344 49497.2420 52070.5404 75064.9201 69560.0560 57455.7019 AICA-riboside 82595.7115 87917.0648 67208.3239 126064.8181 96324.2723 132977.3268 45008.9158 89035.7704 55762.4789 116143.3727 112544.8707 78937.3433 108652.8169 65917.6455 147763.9981 243831.0056 244233.7103 235083.6441 73667.4764 123311.9414 90892.1741 298335.6591 268801.1124 236511.5050 56465.0725 73753.1753 61694.7159 Argininosuccinic acid 289917.2238 412502.3082 464204.7693 958370.2869 922360.9488 1589052.5550 456489.4673 532522.6918 450123.4860 422953.2081 553907.3362 624262.8014 578964.6389 601509.0324 695351.5095 1786633.0630 1750371.7630 934235.6524 445845.2660 769756.0159 678697.2205 651467.5551 1488584.1620 1499706.9330 307615.3056 325591.3419 336051.6027 Asymmetric dimethylarginine 542476.7704 259581.9880 329379.2607 1539510.4220 1271833.2320 1580730.3400 1816366.5570 2299226.3240 1943905.5870 113489.6349 213411.2916 170682.3051 200633.6740 176500.6808 196942.3100 881961.8169 684259.8708 601107.8855 538608.0343 368892.3969 243540.5591 627441.3894 744569.2119 677801.1172 238931.1178 212567.7516 375667.2247 Betaine 104468264.2000 103241791.5000 135829734.6000 82249782.5500 101210717.3000 41311548.5600 73552547.1700 130834804.2000 120226957.6000 28381599.0800 38167238.6600 23158724.1700 23183118.1600 18158330.2700 41104976.1100 400531879.6000 71230045.0700 57616128.8900 122985765.7000 149843397.1000 98298305.5700 26363185.8600 30555110.7400 39465226.6000 32415324.3100 14850250.2800 143832052.5000 Betaine aldehyde 284010195.9000 210588544.6000 315263449.9000 52009577.5300 172851139.5000 151985772.0000 111098913.8000 160770824.2000 168766970.1000 211464334.7000 165914940.0000 282962025.5000 102418021.3000 213454515.0000 155876929.4000 214707656.2000 215989877.6000 205826568.6000 109547546.6000 171222927.7000 215233601.1000 154351492.9000 122110788.2000 61956638.3500 212515283.8000 240657495.1000 62390052.9400 Biotin 31633.7223 139012.5002 1379157.9560 280245.1422 22279.8174 95442.3316 97419.6978 201369.5650 391005.7433 766836.5197 771443.9149 1530753.8930 115409.5427 911103.5159 683072.3584 1056151.1650 1238111.4860 132188.4322 104821.6955 78403.1968 45645.4834 716809.6079 93896.1816 58747.0458 83552.7536 89979.6974 17950.5031 Carnitine 2927339.9900 1650256.4340 1812789.3430 2163645.3010 1262478.2230 1380972.3780 993346.5520 1659835.1870 1569359.5420 799755.9486 380841.2975 507757.1601 471226.0921 279010.2471 400889.0812 3538889.2680 2016801.3880 1266828.2630 1399628.0070 2339016.9810 2061999.1420 1837505.6960 1086532.4230 1031102.9120 473186.0889 184529.3012 2217172.2120 Choline 19221919.6000 6240409.7910 12045761.8000 5135201.7630 4891125.4460 8445687.9740 7788986.2650 12748274.6600 12929363.8000 1101078.5350 1893825.0050 2797488.4620 2024760.9750 2779078.1250 2000293.7990 11170026.8400 5737638.6730 3806709.5530 6815983.6030 8090270.9670 8473058.9920 2838605.1060 3499217.0330 3210015.1250 2712359.6490 1335782.0670 8930314.9470 Citrulline 14826394.7500 28297052.1100 25968526.4000 29491202.2500 26075951.4800 37363299.2800 3543015.7670 5407217.2700 4185691.4080 27490185.7100 36013576.5700 27263649.9800 29993502.4200 21941423.4300 41041425.0000 97928631.7500 101079341.2000 86555981.4300 18639763.6100 34412549.6700 18978828.8300 85059487.1900 62658227.7100 77988622.2500 4650812.5230 3298932.0340 9445699.4620 Coenzyme A 232407.5690 344604.3542 345017.5576 237283.4918 160671.5812 193841.5647 115749.5820 191443.7238 421415.8615 327332.6599 248361.1101 150747.3621 264842.6209 220621.0136 145121.3714 330594.7324 290515.1547 297892.8781 261877.8452 118469.1185 37373.7072 256132.3254 117249.3721 33142.5139 51266.9456 11635.6810 Creatine 10909037.6000 3529208.8780 3371847.9400 7915332.5800 3297919.6160 20547532.9500 5245835.0280 9386163.8390 6738902.6460 1022185.4820 603957.6453 1177884.5430 1395297.3090 616392.4870 3269695.5070 4292891.5820 8683550.2920 4763849.4150 10858300.4300 1659605.0270 3823374.5950 1110150.2470 982227.0776 1722735.9090 2124347.4260 293340.4821 17432374.1500 Creatinine 14443721.7200 1870571.3700 2929378.8880 5020147.3930 3138695.2760 11644946.1900 5277622.5670 5461164.0710 4692894.3170 808524.1174 448299.8987 917875.9043 683172.1619 474460.7082 2807775.1810 3264080.7490 5390316.6550 2595728.7200 5027399.3570 1610192.3460 2612068.8760 700287.8528 629798.7817 916939.5519 1068439.4880 344032.2748 8390695.7950 Cytidine 1416578.9420 2528725.3660 2296618.8920 3057457.9670 2306661.6700 3163657.2420 2155588.6210 3567046.4690 3030168.8820 4564373.8240 5000016.2440 3075143.8870 3433949.6110 3297169.6160 4852801.3180 21051207.9000 22748387.4200 22630615.3200 2222009.5750 3931298.8640 4007184.2490 19805291.2700 15867393.3500 13500012.7100 1559113.2160 2083984.0850 1751624.4150 Cytidine monophosphate 227324.4516 297196.4063 329977.7985 1097640.1680 1009949.1320 948322.3335 729422.8274 1024984.2210 784173.2888 401902.0084 499264.6174 366695.1636 424853.1998 362620.1122 462672.5393 1054043.0030 882072.2641 787879.7574 497887.5391 777250.6194 413227.2027 1145369.4600 1393868.0260 1203276.3430 609136.9921 523607.9794 451052.9782 Cytosine 557787.1626 467530.9371 442169.3229 242717.1090 544773.5139 372123.5656 197277.9635 219435.9400 332955.2558 229426.4602 227095.2942 413933.4591 242394.3134 170913.1457 515159.7806 512384.8197 1488705.4220 383589.2954 112478.6199 716408.1133 228527.2989 256855.6846 519173.6277 761533.5901 90482.9936 859990.3492 279146.1792 dCMP 17440.9678 40999.2461 23681.4763 33026.3878 41050.3048 30978.9378 47050.8877 45560.1598 43623.4215 28679.1135 30054.4766 21578.1172 35284.5308 25718.6800 44444.3863 54633.0384 32145.9871 42404.6059 35394.7641 38064.6617 32274.8379 40405.4718 34265.3720 36447.1127 22806.6630 28650.9879 18860.0043 Deoxyadenosine 1799328.8190 3467972.1710 3418090.0080 3632789.1420 2559925.4200 2878868.6580 1810181.6790 2059241.5450 1797779.6740 1558381.1850 1812216.8160 1836826.4030 3970977.2200 3619543.6970 4664083.4160 6045146.6020 4475021.2160 4911917.9940 1656686.1350 2978255.0360 2628211.7280 4706489.9770 4243837.1360 4519146.6480 669475.0658 728442.4976 1151458.9500 Deoxyadenosine monophosphate 4281266.1070 3785880.0960 5803418.3470 4134041.2530 2555179.2660 5218091.7150 4452667.0690 6796728.8930 5709025.4400 3431147.6670 4716992.0980 5112654.6010 5828489.4770 4534074.4010 6166856.7750 5055738.0430 5153926.7010 6359816.1940 7709820.4750 7463135.8720 5641316.0020 5845710.8060 4990863.2340 3571060.3590 4003298.2080 4718800.3780 6070213.4790 Deoxyguanosine 525839.1580 647596.4463 980248.7446 172426.9949 156716.0938 179656.3047 102464.9766 147405.0709 107796.8650 247807.6340 346112.5703 199002.6761 670187.4003 770512.7682 1323846.0920 498017.7390 476194.1701 627368.9554 234127.4823 387587.3160 561446.5026 595131.0207 432484.8984 397850.4282 153851.4483 153485.9860 197697.1214 Dephospho-CoA 134523.5823 154212.0998 135185.4263 169313.6380 99416.6980 110687.7233 82895.3481 156140.4656 88185.0215 168064.8469 232185.8438 157289.1163 186784.4354 118879.8662 198873.6730 296542.7808 422256.8148 300857.6146 246821.7746 210136.7332 183549.1467 305068.6083 353654.7598 259529.8262 160741.8359 147592.9744 159367.9165 dGMP 25129.7332 11017.4753 37311.3426 44317.1819 42892.6616 27991.9478 37344.4309 88530.1728 36772.7329 20717.5579 32948.5099 22756.2226 38871.6600 58196.1378 52993.0798 22679.7826 23377.3526 30604.1884 34077.1965 26208.5640 31374.7327 51355.5274 35029.7355 48428.4678 29900.8588 48049.9238 44859.7568 Dihydrofolic acid 21155.1979 24576.6852 26889.5618 10154.0582 25144.6421 9395.2141 14827.5142 23660.9290 13606.0645 25406.2426 13960.8252 6896.3858 10010.9947 13650.6340 23172.0673 14340.5016 6325.5246 20426.1200 14950.7533 23891.7283 10630.4932 13844.6655 17273.9671 12887.7010 14448.5150 12778.5944 26854.6015 Dimethylglycine 171413.0371 194619.1078 187740.5573 16253024.7000 12175549.0400 14069326.3100 9828261.3740 15194851.7800 13120120.4300 166648.1563 84669.9480 103274.0670 96112.5893 71491.3011 135980.1501 1313180.9200 1574408.9770 905753.1380 165128.7733 71356.0427 85440.8040 2745916.8560 2773634.0720 120732.9422 36623.7167 365226.7313 DL-2-Aminooctanoic acid 12308.4414 24596.2386 26468.2430 19768.0455 19655.4471 19992.1971 30816.0288 50698.5917 30854.3561 4748.6855 5296.6613 11814.9599 2724.0095 1986.1025 3635.8680 43659.1623 15633.5181 15924.9578 5456.6873 25138.4454 19704.0220 14173.4209 17619.6159 18833.1729 11829.7547 2371.3533 15614.5733 DL-O-Phosphoserine 6506.1258 12327.8380 11854.1900 4950.2487 3378.8717 7076.9649 17298.5508 3409.4692 10197.2418 10806.7330 6279.8090 6676.7725 4901.9325 6468.6776 9229.4293 12061.4449 13281.6058 10005.7451 6681.9163 5157.6777 11305.7253 2892.2772 6854.3686 8752.7551 Ethanolamine 55452.6385 66015.8548 80311.5401 862580.4155 558825.0068 789837.3078 81312.9428 111599.1295 105221.6959 43328.4365 63488.2175 214462.1548 61315.3728 80852.3338 58034.6598 317220.6996 187453.6704 168203.2207 61096.1446 81480.9254 68518.3364 292333.7705 219006.2037 216605.5829 43767.9900 26016.2693 38325.3568 FAD 3908171.9920 4673993.5520 4229594.5420 2468443.0910 2037414.5830 2145767.9020 3428767.9060 5636490.7550 4840900.9270 4786805.4260 5209918.9400 4968227.4510 5038279.3440 5081790.3350 4200946.3360 4460539.6630 4860414.0660 5186924.8930 4612369.6350 4939001.5390 4630023.7090 3993383.1390 4068413.1960 3493576.9510 5475871.9160 4958539.3620 5082898.6620 Flavone 102377.4566 149721.6924 146582.0776 134389.4523 110634.5630 121452.1417 109784.2430 171649.3162 147064.2721 185569.9351 158764.9101 77910.6255 165934.5138 144477.8289 176654.2784 123046.1105 153877.9687 176094.8656 112207.6737 119217.7935 113801.5755 123056.6298 127587.8503 108514.5784 124062.2105 112114.3662 107339.7804 Folic acid 177339.0583 206539.4504 193399.7549 138718.8695 100436.2072 104247.2536 128516.6913 143171.7453 180795.1948 200576.1577 142719.5082 131666.5447 179779.8897 158037.5772 158918.3436 165011.1922 153823.4538 149647.4957 138363.5887 179544.2398 168162.3165 168100.3559 179105.7704 100285.1635 185517.0067 134951.7233 147962.9611 Gamma-Aminobutyric acid 40476.7400 44994.9001 41762.3821 171498.2136 108774.2519 179388.2206 325257.5410 393843.8925 406886.9498 31970.6146 41201.0709 24226.6956 25968.4093 39245.9590 31174.1961 274069.4180 117688.7151 85220.4414 23329.2427 94694.3643 50756.4342 129944.2542 100528.9768 112072.7452 23661.9736 20644.5533 45463.6712 Glucosamine 1094263116.0000 1038424502.0000 1147076313.0000 1120073996.0000 1079883282.0000 1105960098.0000 1124760707.0000 1294212599.0000 1168646380.0000 1071895684.0000 1271990136.0000 1289697555.0000 1324128431.0000 1298718633.0000 1350899707.0000 1159670846.0000 1283474441.0000 1384643492.0000 1168242536.0000 1131668687.0000 1137835657.0000 1307435317.0000 1112989694.0000 1137535487.0000 1133571571.0000 1172007290.0000 1192908537.0000 Glucosamine-1P 11471.9109 7978.2864 16694.2209 32686.6653 20095.8926 10378.1772 26086.2732 20284.9347 21433.7667 9149.4770 14784.5289 14280.7453 25411.5566 17821.2076 16889.1169 19906.4719 9169.2283 26777.2795 13170.3788 14168.2658 12154.9994 32335.7182 5111.7450 15956.9831 14154.8819 13404.1450 13983.8962 Glucosamine 6-phosphate 6507.2536 3588.0697 2376.2292 2640.2219 2420.4826 3843.7582 4814.0203 1738.8212 3732.5133 10142.9087 9923.9040 2219.5231 2491.6590 14113.3725 8816.1327 8323.3001 1608.9740 Glutathione 8430802.7150 14843575.2900 15155546.3300 4829836.5010 2588903.0400 3429074.6780 9712756.2920 15175656.5000 14152378.3400 2997293.4800 4555333.6140 4413124.7570 15359715.9100 11161457.5000 15968736.8500 7030762.0340 5594685.1030 4840350.8590 12991536.2800 22681609.1200 13173875.7700 7270524.0990 7095791.9130 7613830.2610 9483727.6350 8293813.9130 5008919.4780 Glycerophosphocholine 69633612.3000 109118002.4000 103754924.0000 15635199.3300 15111760.4800 15274237.5200 813487055.1000 1776204631.0000 1359333186.0000 48022380.2800 86648049.0800 106095286.6000 91636024.1800 134281016.5000 80573147.6000 92873604.4300 47433161.4800 27861944.8400 50309923.3400 108536958.5000 62661832.4100 30756196.5300 27839273.2900 17388524.4500 281444813.5000 245247704.1000 191194301.6000 Glycine 24410.8896 30242.0014 24855.3696 26792.3803 22722.4573 23694.1732 29190.0370 29810.9518 29318.6046 30140.1864 34929.2824 35877.8176 32882.0549 34685.6041 39584.4016 31268.5797 31845.3120 28145.2082 36701.9477 19524.1434 27457.1772 27256.8210 28001.5901 23681.4609 27745.3177 32289.9895 28449.2899 GMP 486147.1109 681223.1240 695219.9584 920364.9772 806608.3143 754802.5012 516886.7977 459254.6090 513197.2174 527319.6124 830555.7287 719801.2964 944071.3183 899113.4074 1077670.9260 1463644.8560 1238362.7080 1179132.4870 966082.0481 1292176.3900 1239343.2390 1034802.3470 1277260.6570 1173090.3290 598024.1696 578731.2132 620289.8870 Guanine 1268139.6210 1627796.0370 1441328.2490 866126.6286 707431.0119 835312.3692 3511580.3870 4901669.0870 4239334.2750 562933.7189 517867.6113 386804.3245 1111261.1130 1331289.1660 1968742.9050 2324103.9230 3285182.7470 2180313.4830 544897.5777 1126224.3370 1399059.9940 2235338.1430 2212429.4050 1933327.9410 901022.5802 1173090.4050 954546.3629 Guanosine 1006179.4870 1414066.2310 1896213.8500 514013.5741 482823.5578 527520.3802 2541161.4110 2902234.6850 2821752.9090 471039.7217 459407.8632 359125.6717 882297.0069 1127038.7370 2029935.4570 2542801.6600 2304341.6820 1967583.8890 390770.9596 772129.4195 1244132.2230 2239533.3400 1893824.9230 1853688.4600 702066.3360 985006.5496 623850.4851 Homocysteine 11565.0066 20669.4395 20351.3252 186215.2409 121843.7189 235993.1960 29800.4604 54180.8463 21931.1597 35786.4890 20261.2620 18193.2846 21352.5926 15001.8749 12276.9233 299444.5362 282752.6872 234905.0135 13656.2005 36820.0533 15120.5101 623686.2266 467227.9816 412267.9326 21282.8526 3776.4460 10304.3872 Hydroxyproline 1558434.3200 1399849.7310 1617712.4420 1439546.7540 1386414.9400 1354382.5470 1417956.2410 1620729.9310 1538788.6900 1465474.5910 1547202.9830 1781955.4120 1760034.8570 1823608.4390 1638662.0180 1383927.7280 1669496.8500 1719570.6890 1522338.8940 1395056.8930 1269384.9060 1628907.6020 1450594.9610 1399353.9230 1615358.4630 1594552.7630 1517120.0690 Imidazole 122521.6695 93006.1059 57021.2392 509815.0154 294183.8571 199090.3601 196800.3855 199809.4715 183449.7585 149455.8381 115600.9470 148673.5994 177675.8865 137764.7183 184276.8766 214128.3792 520289.0554 226190.4079 175049.3035 187156.7906 141331.2190 175725.4052 608053.1012 209465.6041 146856.0992 129026.5194 249109.7285 Imidazoleacetic acid 555127.0143 320196.3715 433884.9572 748390.4033 464536.8576 900431.9078 313109.7650 607445.0605 525542.1627 206453.8191 280213.1935 254189.4918 370745.5059 328897.8832 390894.0023 723841.3797 900529.7735 848981.4434 615345.5843 458063.0392 322974.8382 1084180.0220 774569.3766 711254.2033 231834.6271 177914.2639 493389.8448 IMP 1133154.2100 1468144.3850 1706752.3340 2288495.4280 1621050.3650 1676027.7470 1068587.6820 1511898.0920 1204301.5000 1035468.6110 1644651.3920 1349379.7180 3187138.8830 2776794.1160 4207336.3250 3587070.6390 3072867.0110 3198823.1290 3959557.1130 4195211.9190 3043641.8960 1982018.7380 2687950.3580 2638824.1950 1657693.0820 1740823.3140 1672483.2160 Indole 128332.3699 82674.5762 111383.2131 220553.6929 183568.8207 280977.4030 120775.8713 206183.1603 198498.2287 102786.4507 119694.0223 106113.7436 110251.6085 88751.0606 99997.9144 538496.5925 461283.4896 295304.4932 125906.2382 119036.7776 139100.1021 462328.6895 454617.3945 381854.6888 25113.9040 33273.8514 87917.5255 L-Acetylcarnitine 3385673.9840 2127727.2320 1407006.9920 5690176.6100 1058858.8090 1050020.5220 1263069.8150 1896943.5340 1768443.6780 1212264.7880 727542.1044 522527.1892 1085019.9620 669076.3070 1106183.9520 3669001.2350 1750984.7270 1561683.3880 1555706.0850 1339716.6920 1281588.7310 5786926.1130 1915951.8250 1629468.3900 952272.7859 739064.7165 2100015.3640 L-Alanine 1763659.5340 1364471.2480 1371597.6840 19157503.9600 11733851.7600 17949240.1800 6990233.1400 9929436.3620 8261032.4700 2425263.0210 2113911.8080 3121536.2430 1690260.1090 1448474.1210 1394209.5780 22899431.1300 14282981.8500 12067216.9200 1846399.9530 2337423.4030 1522062.6460 19261504.3400 14946025.8000 17158844.5200 819510.7689 572830.8407 1939157.5810 L-Arginine 23241963.2400 46391315.1500 41845674.3100 113043209.1000 98297073.6300 107257434.0000 64382585.0200 67943741.1900 57203097.2400 46862233.2300 56845070.6100 50623491.0200 74209495.3000 78221737.9400 79013610.0500 159279801.4000 142384397.5000 110370973.0000 62121019.7600 101135569.6000 69075086.1100 139812031.4000 130787236.7000 124013685.1000 52760845.0900 53709211.0200 53751813.4600 L-Asparagine 376087.1041 527586.4800 505523.0439 2583669.9110 1836807.6110 2701860.2260 1773120.1710 1959141.6220 1856965.6180 849176.0474 890771.5026 757990.9543 600764.3840 607133.8933 633524.3095 4050675.7060 3312714.4590 2544823.4990 492568.6062 1030911.5810 613029.8846 4600099.0630 3639376.3370 3643701.6320 349385.6184 351271.2562 432549.2098 L-Aspartic acid 1680359.7920 2290206.3140 2225660.9670 5950900.6260 4730786.7470 6620719.8830 3811187.4460 3731338.8820 3061576.7460 3616429.7990 3637963.0340 2958372.0900 2415791.1640 2002089.5310 2466767.3690 14123870.2000 11838746.5000 11453144.5000 2102786.6910 4499800.4930 2162212.7100 15314901.2000 13617087.4100 13585100.5900 1932233.4760 1492619.1960 1598679.7090 L-Cystathionine 2022210.2790 2683066.8690 2928235.7040 248928.7030 130190.3386 244001.7287 187358.7754 228158.2185 176428.1854 203438.2170 234836.0104 177469.7193 3104944.4740 3134306.6720 3413258.4660 324989.7295 274648.5848 384220.4479 2426794.6930 3762416.0050 2722085.5020 395356.8695 368196.6070 325004.3017 571614.9178 529062.9946 1145464.5310 L-Cysteine 5053.6175 5206.3531 16089.2373 2847.2336 4600.7373 15131.7795 20261.6338 11570.9043 8015.8353 6310.6241 5170.3166 9623.0808 8100.6949 4541.6699 3030.6079 5284.2768 8388.0366 8123.4778 7707.2766 4944.3784 3480.0943 3425.3477 3672.5353 4989.9880 7457.2995 2623.1310 L-Cystine 35684.5488 41208.7354 24034.8088 14885.5585 24833.1927 14694.2242 3300.7014 1901.0382 3433.0496 3640.1049 2316.0579 5799.2913 9608.9337 14804.2604 15723.6953 10851.0557 4730.8504 2918.9021 24832.3141 L-Glutamic acid 30017296.4400 49554277.0200 45884033.7400 141153483.7000 110155896.9000 143548598.8000 83092512.6700 95378137.1800 82442228.5900 66203049.7300 73804387.9000 59304561.7600 55782095.2100 51764214.4500 67745294.3000 290344032.3000 276398198.7000 224134681.2000 42294984.9800 97995443.7700 51937333.7400 306760503.9000 232813145.6000 238452502.6000 39727097.4900 37781889.6800 29001400.7000 L-Glutamine 21875984.1800 40995525.3600 38366773.2400 147443436.6000 109147744.4000 150182293.8000 90106136.1600 93648192.4200 84733524.0300 86981118.8800 73375746.3600 97179796.2200 57821372.3300 55974799.0800 66619680.8200 261537562.3000 219458222.0000 224414849.7000 31860386.9500 81838737.9500 40011853.5900 257141652.2000 200420869.2000 190861421.0000 22917558.1400 19493119.4000 18637412.9600 L-Histidine 386564.6790 313039.7627 837179.2144 1107746.7020 2055056.9740 1325382.3880 1484355.4590 604081.8671 1684087.6200 258871.9402 L-Histidinol 115885.2855 70684.5759 60336.7064 71676.5400 16362.1643 76187.2378 55514.8207 65021.7414 166970.1168 81863.2284 60094.0227 240740.9128 16562.1694 139232.5131 128455.6261 77568.5344 103073.6273 63338.8299 174644.0799 65416.0462 157832.5232 169608.2399 48710.5295 123793.7700 48669.3220 62911.7846 L-Homoserine 425427.2966 361682.1009 296142.9245 143913.8077 106448.9422 123906.9451 671709.5570 838280.9666 634949.4160 211206.1897 178780.4629 135296.9190 757231.0110 771259.4039 1102751.5060 233692.3794 245160.1578 368043.6345 1085460.3130 879193.7569 911637.9298 268607.0552 211617.1387 174996.9136 282841.3622 437304.6803 800892.7828 L-Kynurenine 138834.9422 233248.3218 159371.3546 1744704.3100 1082587.2740 1791427.6230 3330988.1650 3910871.8110 3479183.8140 207659.2647 226875.2749 281980.3298 117907.3693 138905.2696 175571.8873 1623317.4770 1389604.6490 1192168.5700 137409.8492 278413.3996 219887.6808 1995051.2060 1644898.8890 1627398.8360 949429.3496 741667.0155 509913.4603 L-Leucine 23754234.7800 6942975.9010 17295760.7700 103849953.5000 70934232.4800 90367193.6100 63898135.2500 87065067.3300 79141610.0100 19418943.2900 21185696.1600 22721433.5800 17160237.9300 12135885.2600 18338805.0000 202766866.5000 117083659.7000 94205062.0000 19138848.0300 17208153.3800 13656790.4300 160225689.8000 126078345.5000 117921515.9000 4835883.4310 3258356.9980 19317118.0400 L-Lysine 191586.9424 331834.3897 347739.0964 3567612.0650 2578311.3830 3076487.6110 1817922.7620 1455812.8900 1405730.9190 317397.3493 410047.4083 389676.8508 535093.0168 550187.7858 470405.5586 2419503.3060 2107046.8250 1614875.5140 361615.0624 803086.4565 525651.3626 3380221.1580 3722173.3750 2721371.1210 186181.8660 105458.1116 205610.8442 L-Methionine 1232063.2090 1210559.7450 1109354.1660 114632442.7000 66366911.6500 80236294.2000 18064696.1200 29786636.4100 24051931.2100 12820495.4200 15448081.9300 23318041.4600 1060434.2290 998845.7435 805089.5154 143425263.0000 122796899.2000 92819708.6100 1076457.5740 2007814.5770 1010554.1070 207541804.8000 166336720.9000 218427884.3000 1869462.1560 1210703.3580 1547925.5240 L-Phenylalanine 5840123.1560 4395069.8540 4796926.8580 26038369.9600 19072820.8000 22065155.5900 13355316.5900 15779758.0200 14617739.2800 4942315.1270 4967107.8810 6789632.9550 4108067.2090 2979449.2900 4450078.0850 62223791.8000 35171883.6500 25909160.6000 4138955.8180 7823149.9550 5845337.7720 35634564.7800 29982489.0000 31132748.3900 1539679.4950 1107784.4680 3280009.8580 L-Proline 21657846.5700 14441797.8000 18545595.5900 80104954.2600 45980827.4100 62039713.0600 40821518.3500 68633764.7600 58454111.3500 11988927.8000 12366795.9000 18774961.7900 15600005.8800 14176447.0400 12972368.7300 131332774.1000 105747181.1000 73894594.2000 23460246.0900 25055794.6100 16717497.7400 103285540.8000 93788003.8700 94886011.3500 5765833.7740 3523640.1310 21504207.8100 L-Threonine 3687013.0790 2831350.9360 3809173.9660 18667084.9500 11099009.5600 15948494.9300 7243190.4700 10177785.6300 8403055.0770 3386950.0260 4086401.3200 4985162.3070 4051485.2590 4025280.5820 4667672.6050 16067914.8000 14890832.5100 12328723.3400 3257807.2510 4753089.3910 4005682.0150 21037046.8400 18893276.8400 17624691.9800 1910230.5990 1399583.1920 2684643.0340 L-Tryptophan 1051262.4140 742708.3366 1029367.6290 2161744.2820 1783984.2270 2797348.7340 1381758.2680 2442043.5750 2149130.5180 932161.5783 995771.7737 881616.7965 895937.9798 909461.9189 1028246.3490 5494525.3040 4039294.3740 3324717.4650 942052.7613 1029593.6950 969968.3559 4418740.7530 4548085.1550 3766874.5990 259754.1723 243405.2759 699585.7124 L-Tyrosine 927310.7538 662817.0651 579803.2151 6456812.4290 5349007.1170 6570385.8440 3554370.6970 4905664.6310 4000072.9210 1264064.9460 1532639.5570 1260082.1640 571807.8398 481496.3549 700352.2218 7021728.0060 6958745.7350 5657565.9860 840374.5658 776754.2045 767378.9641 8629150.8250 6523927.5880 6441040.9070 363918.6508 298917.6588 604677.0437 L-Valine 301078.8917 354070.5655 456370.0029 3351734.7220 2036984.3350 2793349.6310 1326466.3970 2278304.1880 1999024.3050 617019.7686 610241.8240 673179.6991 436144.3789 473551.1542 565990.7548 4015838.3100 3678862.1970 3085198.4090 397170.3066 412628.2628 315761.5439 4162077.7440 3540686.3920 3220898.6880 118047.5227 120199.8060 229120.5005 Malonyl-CoA 8568.4060 19111.3440 23818.1959 3348.5900 2140.1192 1829.9208 11089.6366 20089.7596 10140.8439 4090.0700 7018.8800 2679.1327 3102.1452 3105.7615 3638.0768 15763.1826 3016.9526 2198.1586 4066.1488 4077.6454 2055.2340 Methionine sulfoxide 681125.9289 801426.0803 772380.4566 112250101.8000 101420477.5000 139730566.7000 26038919.6800 33823484.0800 29209959.5300 15146093.0500 13001146.0500 13442406.7600 616399.5340 653237.9171 757421.5057 80257918.1200 84951307.2300 99180854.6400 741407.8550 1511920.9530 871699.1648 121248858.2000 89591073.7800 54640761.0900 817531.9721 1270674.6010 1602399.9840 Methylcysteine 816897.9723 632131.1388 664387.5597 5699604.3570 4896078.6330 5217534.2570 3030654.1320 4469973.1980 3303562.2840 1035050.7970 1247022.5510 966015.2686 497744.1668 547306.9280 631878.1229 6538982.4760 5028023.3120 4163243.7140 682216.4948 648255.4795 743689.7100 6586068.3460 6376004.6310 5355767.3410 314850.8746 245940.3231 576005.1737 N6-Acetyl-L-lysine 3799647.8480 6561750.3780 7193032.7990 53443288.6600 34539682.1800 37704882.2400 10999750.4300 19329409.6100 15920015.9200 6227152.4880 7493658.4130 5400832.5330 9506345.8960 7301426.8380 9922211.2220 33953384.0500 32052439.1300 29764807.4300 9085910.9930 15295522.3700 10597375.3900 42842331.6900 46300712.3900 32218240.2900 7037060.1450 6231271.6810 7480475.8710 N-Acetyl-D-glucosamine 306097.6003 95430.1588 149915.2555 284199.2550 197603.9113 224314.1195 128495.7032 165686.7690 181084.3092 83393.3361 62769.9615 99445.3356 116028.2167 85555.8849 131017.5112 180386.1493 259831.7282 219395.0803 220371.7013 167189.1348 131222.0889 274492.5960 261834.2820 188045.0723 169310.3595 169739.4119 267718.4705 N-Acetylglutamic acid 1145107.1410 2248441.2100 2379330.6550 2130683.1460 1519916.6510 2190419.9830 467696.7210 708725.3776 629175.2571 2164479.3490 2461499.0820 1790173.4610 1477875.1630 1176042.5290 1900687.6300 4338327.7870 4098377.0050 5076681.5820 1282007.2830 2014246.3760 952486.1400 4115892.0410 2864831.0790 3409476.1200 251347.1955 475338.5601 234173.9173 N-Acetylglutamine 3667039.5400 6788202.8910 5911728.2180 15491906.2200 10525689.4700 9914176.0830 14618781.0100 20328013.6900 18282425.6500 6582828.8260 8531824.9370 6928694.2840 8441572.0000 8405752.2370 10874010.1800 21409228.0000 18653344.9900 17594680.5800 7945485.6550 15225094.0400 15254718.0400 20061891.2500 19814494.9200 18847483.4300 3376848.7120 4278710.3980 4594196.3480 N-Acetylornithine 2599115.0660 5768873.9220 6025283.9590 26544803.7100 14258188.7500 22765712.9900 7298151.8040 10654304.7000 10016559.1100 3485159.4070 4232629.8650 3432988.0400 4652961.1600 3805056.4850 6128000.2320 17559209.1100 17825628.9300 16320646.3800 3235727.4650 6788682.9320 3062236.2210 25440188.3700 20915598.7700 20647875.4600 889999.1636 1180468.7060 955910.0121 N-Acetylputrescine 540070.0289 676353.0261 886410.4921 34705740.5200 26522566.4300 30007169.5800 3631003.2590 3991631.0630 4036929.4060 976089.6733 1458246.7210 1041365.9030 642553.2698 681893.0134 991768.7666 5986778.5070 5112403.0540 6648827.9970 159818.1300 867903.0620 569642.8218 14582670.1700 13295756.8500 9113470.1610 915147.0265 418419.4731 556651.5826 NAD 98324338.8900 118050107.9000 111307338.8000 118450005.6000 68950055.5100 102755305.1000 112835181.3000 175739465.3000 141557274.7000 80060416.2300 108297612.9000 85763540.4200 114223050.5000 143476768.4000 131892794.4000 107761693.3000 107574400.5000 116668994.5000 132669849.9000 148240161.7000 131296605.0000 131696579.9000 116211537.9000 101672760.0000 98845266.9300 91041183.4800 95771348.5000 NADH 12681612.6600 15701037.2600 16771181.8100 8729845.5400 5955179.2690 8327596.7100 12817439.6500 24772164.6200 18208105.3900 7936673.7000 11250292.3600 8355162.7960 20421587.9100 13614290.0600 15094599.0500 17467090.0200 10996776.7100 12694865.7900 20348271.4700 24493624.2100 18469535.9600 8827872.4750 8323114.7100 12496256.8800 24217889.3300 15704021.2500 14273915.1100 NADP 3416999.0460 4081553.2470 4081660.0990 3291720.6700 2527547.7030 2694370.3310 3781992.8960 3285546.5550 3456544.9190 4205117.8830 6553389.3440 4401568.7420 3409148.4890 4561575.6750 3166423.7200 4977662.6880 4178483.8190 4592792.7090 3936328.7110 3516965.4490 3575291.8840 6453251.1340 5422309.3820 3369432.4540 3660336.9590 2828706.5830 2693044.8420 NADPH 1307823.6700 1573475.4810 1945254.0310 600280.3041 381005.5095 357521.1984 558783.7894 659779.5335 574883.2178 1622962.9930 2302928.7920 2498567.5120 1272026.3260 1701023.1030 992569.1138 2441678.7150 1780485.5400 1730887.5130 1018689.4400 985406.3093 913467.4781 1093366.8400 1890857.4980 1933991.1770 655583.2134 683823.4879 626315.4071 N-Alpha-acetyllysine 2827663.7390 5204680.9290 5624796.4630 40200606.5500 24575897.8200 29290342.9700 8370575.6290 15079288.4200 11913100.3600 4402119.3190 5675580.6260 4551694.9910 6503977.8070 6340485.3870 7950333.6650 26262769.1600 22261157.0900 21269505.8600 6718267.0760 12047358.1000 7338434.1770 35563282.3000 33615273.0200 27982027.3500 5496465.0320 4523438.3160 5662647.5660 Niacinamide 1220574.2530 1896660.2220 1295421.8650 5778947.5340 2575596.7800 2577392.5200 4157685.8130 3982634.1370 3694568.3830 2132032.3030 2857492.5400 1403367.6320 7631382.3110 2325527.2830 4549379.0660 4245910.1890 3650375.5710 4296959.4760 4183973.5670 3198279.1380 2656827.7080 5032408.0480 5772413.0790 7130724.0620 1551160.1520 1454806.7950 4527066.9140 Nicotinamide ribotide 712379.9250 1092558.5790 1073755.5510 2379862.4980 1943849.4800 2060034.4740 1740288.4500 2139997.3810 1538782.7110 1177055.6360 1757495.8050 1124120.3410 1576299.4990 1336916.9470 1459150.5350 3155204.2310 3184883.1160 2896789.4230 1089496.7340 1307298.2720 1807469.9990 3579172.5820 2975863.4280 3032278.6300 579688.8898 540326.1949 526722.9119 O-Acetylserine 139762.5573 133365.8250 104380.8848 350678.2624 139717.2559 90831.6307 94989.8740 78563.4313 136182.4617 202803.5306 242773.1659 132569.4589 432706.0067 188165.1757 348242.4711 310308.0264 243752.0379 525795.8088 280915.4154 146603.1528 91911.1404 260559.2053 240368.3332 321764.7212 230237.6064 103275.9261 307970.2583 Ornithine 4371321.2770 4177009.1530 5016671.7990 44165250.1800 32598425.9900 35725385.7800 15503238.9900 14920290.5500 10868164.1400 7387202.6960 7962330.3350 7244026.3300 6758252.7260 7772588.0480 8663924.1990 32747854.4300 29941312.4200 21068991.8100 5336942.6970 6091042.3630 4129817.8640 45431120.7600 41295674.2900 31581529.0300 1445010.1220 1099536.6930 2603799.5980 Oxidized glutathione 3311022.9300 3790701.0490 3885685.5860 2957417.5210 2539937.1470 2716223.5080 8558998.9680 9032859.6880 8044993.3280 1362968.3640 1657321.3130 1180496.6550 4038527.9440 4101489.2690 5951073.3830 2616566.9730 2506605.9510 3035852.4730 6409204.0840 8156367.8530 5751528.6710 3105074.5490 2782170.4520 2513751.2250 5541878.8210 5118884.5370 4820762.6740 Phosphorylcholine 221996.2013 401639.8944 766941.2245 340807.4184 583802.4128 638904.9907 11955877.9400 28429775.4700 26219852.0300 79725.2447 124645.2883 202531.6534 210944.7848 215558.5262 215191.8941 810868.4640 697649.5081 209202.6880 240072.2813 729630.4468 500132.7549 224601.3189 401767.6824 249475.9010 539152.9843 870046.6357 1177101.1080 Pipecolic acid 67867275.6800 113657127.5000 112105346.8000 421993106.5000 306208292.1000 392250273.4000 226664154.7000 266573714.9000 234572163.9000 231998384.5000 216791909.7000 237995095.6000 164590324.2000 148663004.9000 183750770.7000 705134512.8000 625148953.8000 586253728.5000 96206259.3600 221601481.6000 121799128.0000 714332093.0000 522514523.9000 554381366.1000 70501066.6100 64287211.0300 54961570.6100 Propionyl-CoA 95354.5857 115278.8378 73505.6996 36489.0070 31521.8868 17655.0960 49025.5957 8104.3796 41126.7081 12524.9604 14747.7176 31397.2680 40520.0882 86320.2373 52277.0310 10395.5377 13121.0577 32667.6976 111464.5792 93006.4891 90252.7900 7911.5370 31784.3423 10979.4880 95090.7996 27999.8738 90970.2152 Purine 150307.3832 108082.6778 124157.4521 512375.0855 375828.7616 445303.3557 320048.9049 308006.0771 333970.5131 118081.2738 153770.3835 186958.8104 108843.8398 92729.9248 118989.9265 1369542.6890 702084.8150 498558.1032 90077.5565 154338.2543 146267.7916 809668.9148 614685.8559 622411.7378 46498.4114 52627.4116 82832.0357 Putrescine 1030136.4180 1539370.0130 1143301.9530 1707227.9940 1692916.6970 1774171.6890 873969.2434 1962171.4470 1827130.4370 1559370.3200 981060.7652 1284963.4840 1240885.4550 1139312.1330 369365.7171 519863.1168 935196.9393 713300.3461 478664.6948 1101383.4920 988133.6404 514776.6699 1464411.4670 1541265.4470 1609314.5810 1706293.5240 1631771.8730 Pyridoxamine 7278.2893 9350.2746 11651.4974 37447.6074 17525.7506 28101.7499 6263.3019 25036.2719 24355.9629 11540.5446 15880.6915 13816.3921 5638.4571 17416.3265 13961.5127 16469.1604 25505.8113 5466.4393 13057.5688 29419.1336 20358.8620 5189.0854 9200.5569 25760.0226 11916.0582 13975.0162 11223.9944 Pyridoxine 450679.4101 551052.8396 966820.6416 601088.9985 768538.9757 806957.0346 403870.7843 436032.4087 377009.8014 410764.5031 1464214.9590 5188128.1970 3293761.9220 3080109.9000 2167005.0100 1512414.4220 349563.3588 272369.9853 155866.2516 461424.2022 477987.9961 1519755.1720 551371.1533 687395.8319 398100.1721 186649.1625 338275.4098 Riboflavin 292215.9363 326902.4983 429720.3393 155578.5234 98205.3910 95885.4379 162005.8484 210899.1837 192074.4045 257730.9712 326206.6522 270008.0334 483840.9904 402771.0075 479753.7450 529703.4355 353635.8803 372799.6302 303431.2994 432710.2356 356887.3184 309906.8108 357114.9032 364734.0830 368483.7870 332370.3525 271324.7354 S-Adenosylhomocysteine 10293309.7700 11771013.4100 10897846.0500 2039493.7400 1533370.9410 2227220.3030 2264333.1910 2359785.5540 2089779.1210 1886724.7620 2140169.9070 1713854.4840 14879621.6400 12870824.3700 17670324.5100 5272519.0900 5053507.3120 5225329.7310 12707530.9300 14355011.3200 17458320.1300 5101561.0470 5742134.3300 5997276.9570 4096378.6690 3874602.5800 6100412.1350 S-Adenosylmethioninamine 504739.4931 201077.1649 192673.6461 201621.6750 168200.6724 88002.9063 269183.9552 795322.5062 509417.0764 174389.8567 47786.7775 795032.2375 3041018.2670 513187.1915 1120911.4010 635167.4557 132637.9787 185864.4244 196020.5456 780117.9303 1251103.9410 163885.8899 494114.6375 407325.0726 468470.9719 94343.8009 177239.7222 S-Adenosylmethionine 386419056.7000 501923621.1000 446367188.0000 129137224.7000 105474053.4000 101826366.5000 543019348.9000 527563540.7000 426403322.5000 189770026.1000 253560466.3000 208390579.8000 430360934.1000 474609402.2000 524932969.9000 235738812.5000 199012109.9000 246248500.8000 380477241.7000 441481259.9000 455948879.2000 174334396.1000 134697677.9000 147357638.1000 279636134.0000 277506092.2000 318317347.5000 Sarcosine 493785.2276 305660.7763 320648.2847 2558402.5880 1482512.1660 2926370.3560 990694.9137 1470080.6670 1138974.6020 299059.3692 334300.2136 416138.5136 246013.4406 209035.6442 283709.5187 2910712.6460 2021269.1170 1718895.5240 597299.2707 363066.2575 325316.2945 2253056.0490 1767222.5120 2060701.2530 174098.2112 82057.4839 869260.3299 Serine 4013111.5980 1425015.0600 2021300.6720 4640103.2220 3319251.8030 4932780.1490 4143373.1190 4972418.2430 4744777.4680 1863085.0220 1900541.5930 2097703.2730 1646806.8940 1324902.7670 1464559.4620 6417402.0930 7335460.5340 4949283.5030 3073083.1190 1969037.8340 1721237.0580 5933975.3270 4875330.8600 4864163.2960 816709.0099 727495.4226 2863509.4840 Spermidine Spermine S-Ribosyl-L-homocysteine 9470.8412 1842.7168 5169.9921 2689.1932 5595.3432 2870.5353 3966.1180 9792.5870 1993.2239 3634.9292 8066.0615 4591.1221 9314.8047 2314.8554 31327.1390 5295.5104 3217.0429 7595.6638 5922.3382 6291.0013 3519.4428 4856.2625 3425.5980 Succinyl-CoA 2391.8733 1918.2916 1674.2914 Thiamine 101162087.9000 149291174.3000 156426170.4000 128890809.3000 105805875.3000 104641429.5000 75334804.4100 82271979.5100 83095920.2700 68190219.4200 98893504.2200 77645304.0200 77586084.9400 69785651.5100 81918747.1900 166428385.5000 127004861.5000 191700755.7000 75889501.7400 101465152.0000 75378716.0000 241419459.3000 188701389.4000 188940084.5000 88940875.7200 69384606.8800 59201797.4800 Thiamine monophosphate 74577.2135 87463.1209 89197.9943 113240.3889 75457.7566 85184.6246 43269.9771 72650.6669 45008.9083 80449.4826 128747.7612 92806.3488 108448.3315 136583.0852 127661.9718 165878.5983 159860.8646 189970.0205 122345.0552 128841.2482 100281.7440 255372.5904 151286.4762 183962.6547 67857.2471 73577.6281 64455.2942 Thymine 57665.9324 197615.9130 708334.5358 543516.9737 801621.9968 994181.6012 847900.0283 630662.0785 823401.8896 896371.8573 959658.0932 1082309.0600 1122247.2060 1006251.4190 1216568.5530 1110423.3430 1184093.4030 902630.9283 1296730.8930 781852.0951 1065708.6230 909867.7917 793950.1815 770773.8391 902134.5932 855323.7531 351957.8067 Urea 3379955.0590 1376118.2960 2149967.4720 2280533.1070 1580665.8280 2474644.5970 1597541.8120 1930665.1860 1666403.1150 930819.8420 1228032.6470 1158236.6650 1022470.8700 1331197.2610 2004656.6560 774591.8597 3612897.7150 1864613.8490 2852975.0390 781563.9420 1072330.7980 743831.6921 782519.6258 1019233.1070 896796.7749 592373.8709 4431425.2210 Ureidosuccinic acid 53074.2320 71775.1427 65461.5466 61869.3695 71569.0148 97140.8571 40131.2800 93469.8441 75546.6565 42869.4167 85234.2081 66311.9074 55281.6995 42838.2303 55302.2296 414333.7249 359402.5966 286435.9061 52474.5802 86279.3131 66325.8431 349529.8595 357355.9378 311957.7023 62046.8525 58529.6551 67654.5331 Uridine 5^-monophosphate 196128.0437 229619.9860 196017.4135 742882.5129 640277.8814 587782.7216 873486.7218 888449.5445 730631.9087 239548.7956 328159.8284 210419.3921 297057.4038 215406.1424 296027.2266 670429.1454 580377.9757 547582.4422 321259.9771 390210.4245 310757.2199 596549.6454 637280.4566 688612.9627 226081.3137 196957.0938 210093.0902 Xanthylic acid 4348.8782 3576.1220 3949.2065 3548.8569 2631.0862 2360.0775 2207.0981 3902.0226 4768.4722 7171.4353 4033.2414 2717.4675 4305.1329 2361.6817 2389.0650 9701.9001 3188.1695 2303.8092 1914.7968 3362.6297 3873.6541 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name pubchem_id inchi_key kegg_id other_id other_id_type ri ri_type moverz_quant 13C-Alanine-1 13C-Arginine-1 13C-Aspartate-1 13C-Cystine-1 13C-Glutamic acid-1 13C-Glycine-1 13C-Histidine-1 13C-Iso Leucine-1 13C lysine 13C-Lysine-1 13C-Methionine-1 13 C phenylalanine 13C-Phenylalanine-1 13C-Proline1 13C-Serine-1 13C-Threonine-1 13C tyrosine 13C-Tyrosine 13C valine-1 13C-Valine-1 1-Methyladenosine 1-Methylhistidine 1-Methylnicotinamide 3,5-Diiodothyronine 5-Methoxytryptophan 5-Methyltetrahydrofolic acid 5'-Methylthioadenosine 5-Thymidylic acid 7-Methylguanosine Acetoacetyl-CoA Acetyl-CoA Adenine Adenosine Adenosine monophosphate AICAR AICA-riboside Argininosuccinic acid Asymmetric dimethylarginine Betaine Betaine aldehyde Biotin Carnitine Choline Citrulline Coenzyme A Creatine Creatinine Cytidine Cytidine monophosphate Cytosine dCMP Deoxyadenosine Deoxyadenosine monophosphate Deoxyguanosine Dephospho-CoA dGMP Dihydrofolic acid Dimethylglycine DL-2-Aminooctanoic acid DL-O-Phosphoserine Ethanolamine FAD Flavone Folic acid Gamma-Aminobutyric acid Glucosamine Glucosamine-1P Glucosamine 6-phosphate Glutathione Glycerophosphocholine Glycine GMP Guanine Guanosine Homocysteine Hydroxyproline Imidazole Imidazoleacetic acid IMP Indole L-Acetylcarnitine L-Alanine L-Arginine L-Asparagine L-Aspartic acid L-Cystathionine L-Cysteine L-Cystine L-Glutamic acid L-Glutamine L-Histidine L-Histidinol L-Homoserine L-Kynurenine L-Leucine L-Lysine L-Methionine L-Phenylalanine L-Proline L-Threonine L-Tryptophan L-Tyrosine L-Valine Malonyl-CoA Methionine sulfoxide Methylcysteine N6-Acetyl-L-lysine N-Acetyl-D-glucosamine N-Acetylglutamic acid N-Acetylglutamine N-Acetylornithine N-Acetylputrescine NAD NADH NADP NADPH N-Alpha-acetyllysine Niacinamide Nicotinamide ribotide O-Acetylserine Ornithine Oxidized glutathione Phosphorylcholine Pipecolic acid Propionyl-CoA Purine Putrescine Pyridoxamine Pyridoxine Riboflavin S-Adenosylhomocysteine S-Adenosylmethioninamine S-Adenosylmethionine Sarcosine Serine Spermidine Spermine S-Ribosyl-L-homocysteine Succinyl-CoA Thiamine Thiamine monophosphate Thymine Urea Ureidosuccinic acid Uridine 5'-monophosphate Xanthylic acid METABOLITES_END #END