#METABOLOMICS WORKBENCH hjyoo2_20230330_221455 DATATRACK_ID:3829 STUDY_ID:ST002550 ANALYSIS_ID:AN004199 PROJECT_ID:PR001642
VERSION             	1
CREATED_ON             	April 7, 2023, 3:26 pm
#PROJECT
PR:PROJECT_TITLE                 	Targeted metabolomics for ARDS
PR:PROJECT_SUMMARY               	Acute respiratory distress syndrome (ARDS) is a heterogeneous disease in its
PR:PROJECT_SUMMARY               	etiology and clinical aspects, and it has been an important interest in how to
PR:PROJECT_SUMMARY               	diagnose it and classify its subtypes, and apply them to treatment. Metabolomics
PR:PROJECT_SUMMARY               	is becoming important for identifying ARDS biology and distinguishing subtypes.
PR:PROJECT_SUMMARY               	The aim of this study is to identify metabolites distinguishing sepsis-induced
PR:PROJECT_SUMMARY               	ARDS patients from healthy controls using a targeted metabolomics approach, and
PR:PROJECT_SUMMARY               	to find out whether direct and indirect ARDS are metabolically distinct groups
PR:PROJECT_SUMMARY               	and confirm their metabolites and associated pathways. Targeted metabolomics was
PR:PROJECT_SUMMARY               	performed to explore metabolome changes between pARDS (pediatric ARDS) and
PR:PROJECT_SUMMARY               	eARDS.
PR:INSTITUTE                     	Asan Medical Center
PR:LAST_NAME                     	Yoo
PR:FIRST_NAME                    	Hyun Ju
PR:ADDRESS                       	88, Olympic-ro 43-gil, Songpa-gu
PR:EMAIL                         	yoohyunju@amc.seoul.kr
PR:PHONE                         	0230104029
#STUDY
ST:STUDY_TITLE                   	Targeted metabolomics for ARDS
ST:STUDY_SUMMARY                 	Acute respiratory distress syndrome (ARDS) is a heterogeneous disease in its
ST:STUDY_SUMMARY                 	etiology and clinical aspects, and it has been an important interest in how to
ST:STUDY_SUMMARY                 	diagnose it and classify its subtypes, and apply them to treatment. Metabolomics
ST:STUDY_SUMMARY                 	is becoming important for identifying ARDS biology and distinguishing subtypes.
ST:STUDY_SUMMARY                 	The aim of this study is to identify metabolites distinguishing sepsis-induced
ST:STUDY_SUMMARY                 	ARDS patients from healthy controls using a targeted metabolomics approach, and
ST:STUDY_SUMMARY                 	to find out whether direct and indirect ARDS are metabolically distinct groups
ST:STUDY_SUMMARY                 	and confirm their metabolites and associated pathways. Targeted metabolomics was
ST:STUDY_SUMMARY                 	performed to explore metabolome changes between pARDS (pediatric ARDS) and
ST:STUDY_SUMMARY                 	eARDS.
ST:INSTITUTE                     	Asan Medical Center
ST:LAST_NAME                     	Yoo
ST:FIRST_NAME                    	Hyun Ju
ST:ADDRESS                       	88, Olympic-ro 43-gil, Songpa-gu
ST:EMAIL                         	yoohyunju@amc.seoul.kr
ST:PHONE                         	0230104029
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Male and female
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	D_Serum_1	D_Serum_1	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_1_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_1.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_1_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_2	D_Serum_2	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_2_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_2.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_2_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_3	D_Serum_3	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_3_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_3.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_3_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_4	D_Serum_4	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_4_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_4.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_4_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_5	D_Serum_5	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_5_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_5.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_5_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_61	C_Serum_61	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_61_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_61.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_61_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_62	C_Serum_62	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_62_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_62.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_62_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_63	C_Serum_63	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_63_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_63.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_63_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_64	C_Serum_64	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_64_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_64.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_64_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_65	C_Serum_65	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_65_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_65.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_65_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_31	B_Serum_31	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_31_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_31.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_31_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_32	B_Serum_32	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_32_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_32.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_32_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_33	B_Serum_33	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_33_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_33.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_33_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_34	B_Serum_34	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_34_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_34.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_34_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_35	B_Serum_35	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_35_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_35.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_35_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_6	D_Serum_6	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_6_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_6.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_6_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_7	D_Serum_7	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_7_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_7.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_7_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_8	D_Serum_8	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_8_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_8.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_8_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_9	D_Serum_9	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_9_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_9.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_9_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_10	D_Serum_10	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_10_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_10.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_10_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_66	C_Serum_66	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_66_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_66.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_66_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_67	C_Serum_67	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_67_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_67.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_67_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_68	C_Serum_68	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_68_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_68.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_68_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_69	C_Serum_69	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_69_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_69.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_69_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_70	C_Serum_70	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_70_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_70.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_70_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_36	B_Serum_36	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_36_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_36.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_36_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_37	B_Serum_37	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_37_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_37.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_37_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_38	B_Serum_38	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_38_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_38.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_38_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_39	B_Serum_39	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_39_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_39.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_39_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_40	B_Serum_40	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_40_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_40.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_40_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_11	D_Serum_11	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_11_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_11.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_11_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_12	D_Serum_12	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_12_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_12.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_12_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_13	D_Serum_13	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_13_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_13.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_13_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_14	D_Serum_14	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_14_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_14.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_14_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_15	D_Serum_15	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_15_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_15.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_15_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_71	C_Serum_71	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_71_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_71.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_71_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_72	C_Serum_72	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_72_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_72.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_72_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_73	C_Serum_73	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_73_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_73.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_73_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_74	C_Serum_74	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_74_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_74.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_74_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_75	C_Serum_75	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_75_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_75.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_75_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_41	B_Serum_41	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_41_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_41.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_41_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_42	B_Serum_42	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_42_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_42.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_42_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_43	B_Serum_43	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_43_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_43.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_43_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_44	B_Serum_44	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_44_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_44.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_44_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_45	B_Serum_45	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_45_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_45.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_45_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_16	D_Serum_16	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_16_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_16.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_16_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_17	D_Serum_17	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_17_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_17.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_17_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_18	D_Serum_18	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_18_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_18.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_18_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_19	D_Serum_19	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_19_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_19.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_19_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_20	D_Serum_20	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_20_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_20.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_20_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_76	C_Serum_76	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_76_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_76.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_76_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_77	C_Serum_77	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_77_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_77.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_77_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_78	C_Serum_78	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_78_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_78.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_78_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_79	C_Serum_79	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_79_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_79.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_79_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_80	C_Serum_80	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_80_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_80.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_80_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_46	B_Serum_46	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_46_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_46.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_46_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_47	B_Serum_47	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_47_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_47.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_47_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_48	B_Serum_48	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_48_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_48.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_48_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_49	B_Serum_49	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_49_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_49.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_49_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_50	B_Serum_50	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_50_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_50.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_50_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_21	D_Serum_21	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_21_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_21.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_21_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_22	D_Serum_22	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_22_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_22.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_22_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_23	D_Serum_23	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_23_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_23.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_23_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_24	D_Serum_24	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_24_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_24.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_24_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_25	D_Serum_25	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_25_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_25.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_25_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_81	C_Serum_81	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_81_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_81.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_81_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_82	C_Serum_82	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_82_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_82.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_82_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_83	C_Serum_83	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_83_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_83.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_83_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_84	C_Serum_84	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_84_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_84.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_84_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_85	C_Serum_85	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_85_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_85.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_85_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_51	B_Serum_51	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_51_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_51.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_51_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_52	B_Serum_52	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_52_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_52.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_52_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_53	B_Serum_53	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_53_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_53.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_53_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_54	B_Serum_54	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_54_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_54.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_54_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_55	B_Serum_55	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_55_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_55.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_55_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_26	D_Serum_26	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_26_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_26.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_26_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_27	D_Serum_27	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_27_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_27.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_27_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_28	D_Serum_28	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_28_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_28.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_28_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_29	D_Serum_29	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_29_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_29.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_29_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_30	D_Serum_30	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_30_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_30.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_30_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_86	C_Serum_86	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_86_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_86.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_86_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_87	C_Serum_87	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_87_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_87.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_87_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_88	C_Serum_88	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_88_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_88.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_88_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_89	C_Serum_89	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_89_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_89.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_89_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_90	C_Serum_90	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_90_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_90.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_90_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_56	B_Serum_56	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_56_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_56.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_56_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_57	B_Serum_57	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_57_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_57.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_57_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_58	B_Serum_58	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_58_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_58.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_58_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_59	B_Serum_59	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_59_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_59.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_59_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_60	B_Serum_60	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_60_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_60.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_60_1_5.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	This study was approved by the Asan Institutional Review Board (IRB No.
CO:COLLECTION_SUMMARY            	2019-1017). The inclusion criteria for the cohort were as follows: adult
CO:COLLECTION_SUMMARY            	patients aged > 18 years, patients admitted to the medical intensive care unit
CO:COLLECTION_SUMMARY            	(ICU) and clinically diagnosed as sepsis according to the Sepsis-2 definition16,
CO:COLLECTION_SUMMARY            	and those enrolled within 48 hours of ICU admission. The patients' serum was
CO:COLLECTION_SUMMARY            	collected at the time of sepsis cohort enrollment. The healthy control registry
CO:COLLECTION_SUMMARY            	included healthy people who visited the Health Screening and Promotion Center at
CO:COLLECTION_SUMMARY            	Asan Medical Center. The diagnosis of direct ARDS and indirect ARDS was made
CO:COLLECTION_SUMMARY            	through a blind review by the two intensivists reaching the same judgment.Since
CO:COLLECTION_SUMMARY            	the eligible ARDS patients belonged to the sepsis cohort, the direct ARDS group
CO:COLLECTION_SUMMARY            	included pulmonary ARDS patients with pneumonia-induced sepsis, and the indirect
CO:COLLECTION_SUMMARY            	ARDS included extrapulmonary ARDS patients with non-pneumonia induced sepsis.
CO:SAMPLE_TYPE                   	Blood (serum)
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	not available
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	50 μL human serum was mixed well, and 50 μL of internal standard solutions (50
SP:SAMPLEPREP_SUMMARY            	nM C17 ceramide for sphingolipid; 200 nM 18:0 D70 PC and 1 μM 16:0 D31-18:1 PE
SP:SAMPLEPREP_SUMMARY            	for plasmalogen and PC/PE profiling) were added. Metabolites were extracted from
SP:SAMPLEPREP_SUMMARY            	aqueous and organic phases by liquid-liquid extraction after the addition of
SP:SAMPLEPREP_SUMMARY            	chloroform and H2O. Nonpolar metabolites containing lipids were collected from
SP:SAMPLEPREP_SUMMARY            	the lower organic phase. The organic phases were dried under vacuum and stored
SP:SAMPLEPREP_SUMMARY            	at -20℃oC until further analysis. The dried matter was reconstituted with 50
SP:SAMPLEPREP_SUMMARY            	μL of MeOH prior to LC-MS/MS analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	LC-MS/MS (MRM) for sphingolipid
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 1290
CH:COLUMN_NAME                   	Agilent Pursuit 5 C18 (150 x 2.1mm,5um)
CH:SOLVENT_A                     	5 mM ammonium formate/MeOH/tetrahydrofuran(500/200/300)
CH:SOLVENT_B                     	5 mM ammonium formate/MeOH/tetrahydrofuran(100/200/700)
CH:FLOW_GRADIENT                 	50% A for 0 min, 50% A for 5 min, 50 to 30% A for 3 min, 30% A for 7 min, 30 to
CH:FLOW_GRADIENT                 	10% A for 7 min, 10% A for 3 min, 10 to 50% A for 0.1 min, and 50% A for 4.9 min
CH:FLOW_RATE                     	200 µL/min
CH:COLUMN_TEMPERATURE            	30
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 5500 QTrap
MS:INSTRUMENT_TYPE               	QTRAP
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Data analysis was performed using Analyst 1.5.2 software. Extracted ion
MS:MS_COMMENTS                   	chromatograms (EIC) corresponding to each metabolite were used for quantitation
MS:MS_COMMENTS                   	(MRM). The area under the curve of each EIC was normalized to that of the
MS:MS_COMMENTS                   	internal standard. For ceramides and sphingomyelins, the calibration range was
MS:MS_COMMENTS                   	generally 0.1 nM to 10 μM with R2>0.99
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	nM
MS_METABOLITE_DATA_START
Samples	D_Serum_1	D_Serum_2	D_Serum_3	D_Serum_4	D_Serum_5	D_Serum_6	D_Serum_7	D_Serum_8	D_Serum_9	D_Serum_10	D_Serum_11	D_Serum_12	D_Serum_13	D_Serum_14	D_Serum_15	D_Serum_16	D_Serum_17	D_Serum_18	D_Serum_19	D_Serum_20	D_Serum_21	D_Serum_22	D_Serum_23	D_Serum_24	D_Serum_25	D_Serum_26	D_Serum_27	D_Serum_28	D_Serum_29	D_Serum_30	C_Serum_61	C_Serum_62	C_Serum_63	C_Serum_64	C_Serum_65	C_Serum_66	C_Serum_67	C_Serum_68	C_Serum_69	C_Serum_70	C_Serum_71	C_Serum_72	C_Serum_73	C_Serum_74	C_Serum_75	C_Serum_76	C_Serum_77	C_Serum_78	C_Serum_79	C_Serum_80	C_Serum_81	C_Serum_82	C_Serum_83	C_Serum_84	C_Serum_85	C_Serum_86	C_Serum_87	C_Serum_88	C_Serum_89	C_Serum_90	B_Serum_31	B_Serum_32	B_Serum_33	B_Serum_34	B_Serum_35	B_Serum_36	B_Serum_37	B_Serum_38	B_Serum_39	B_Serum_40	B_Serum_41	B_Serum_42	B_Serum_43	B_Serum_44	B_Serum_45	B_Serum_46	B_Serum_47	B_Serum_48	B_Serum_49	B_Serum_50	B_Serum_51	B_Serum_52	B_Serum_53	B_Serum_54	B_Serum_55	B_Serum_56	B_Serum_57	B_Serum_58	B_Serum_59	B_Serum_60
Factors	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS
C14_Ceramide	7.49635119	8.415059524	7.951845238	7.365107143	9.573095238	8.629920379	11.83404347	4.354034861	11.27583387	11.16419195	16.04071565	11.26454751	9.101754386	11.17443113	12.07559493	10.73853287	11.42579897	12.71442292	10.30899155	9.364000662	13.0424581	12.73330354	8.714294227	12.19228305	10.16345624	5.944583333	5.374689394	5.079916667	5.8365	7.939212121	14.43684524	5.265202381	6.461839286	7.519511905	7.797440476	9.500727351	19.76061975	5.436961481	10.50550463	9.1546374	16.40118117	11.80524579	8.461928088	12.88664235	12.25582769	7.130385825	10.82444113	10.9103494	7.044477563	12.88623944	17.19672253	15.36111732	9.197348231	9.409891993	13.11974674	7.487227273	7.231757576	9.226386364	5.51225	8.499280303	9.495892857	10.65392857	6.145309524	3.968202381	6.28427381	10.41619109	12.05732731	3.405078545	7.502336992	12.16896923	10.18315095	6.163960396	8.173555671	9.462219906	9.462219906	9.192184136	9.965358503	10.39489982	7.053068389	11.25398245	10.72379888	17.66045438	6.666145251	10.26006704	5.642070764	5.404166667	8.39119697	6.897681818	5.040613636	4.677060606
C16_Ceramide	207.9768293	173.3140244	163.6854675	182.9425813	204.1254065	255.2354822	192.6680294	118.1829665	192.6680294	211.5375786	326.87025	206.070375	168.9619167	198.1749583	205.2808333	188.0616834	213.4539782	174.5720268	224.5631072	223.769598	251.4621966	279.5862581	203.4858565	264.6970491	191.9053606	172.4844872	225.9303846	131.1853846	212.5689103	293.9524359	1193.941057	184.8682927	405.3622459	346.6280488	248.4167683	295.9539832	504.5121593	254.242348	450.882914	480.6769392	526.6242917	370.2950417	424.7734167	562.9432083	363.1891667	318.1971943	369.7752931	434.8430486	369.7752931	618.9371859	694.8297538	627.001135	532.7028112	375.5389384	367.2671556	428.781859	730.0223718	392.3414744	323.1047436	258.7267308	221.4568089	540.1620427	163.6854675	210.8653963	275.3767276	321.7754717	490.6082809	95.14225367	268.1462264	429.0339623	947.45	251.07425	450.03875	177.646875	300.0258333	245.1943467	285.6633166	452.3002513	616.5566583	588.7838358	464.8741924	400.3542867	258.0796228	572.4073686	266.3514056	258.7267308	437.2846154	225.9303846	242.9358974	438.4992949
C18_Ceramide	71.81634111	67.33670796	52.33349214	95.99213911	111.6353025	63.5625	55.6875	49.78125	110.625	84.65625	228.1311787	76.27072243	105.66673	102.3752852	75.36273764	122.3502907	113.6729651	149.25	205.6526163	156.1918605	109.2648837	148.555814	93.02093023	133.7002326	103.8502326	93.37824957	73.4610052	78.1169844	148.732669	151.3193241	647.7691758	91.72582182	195.5395426	135.1000476	36.47701286	30.75	190.3125	93.09375	132.1875	199.6875	276.9353612	250.8307985	179.3269962	152.0874525	161.1673004	149.25	209.9912791	154.4563953	156.1918605	266.3938953	173.5465116	132.4506977	281.8395349	169.3813953	194.372093	84.84228769	144.8526863	139.6793761	116.7874783	31.03986135	79.63792282	396.7675083	30.14864221	115.1905669	154.2984755	135	143.4375	18.75	169.6875	195.9375	365.4638783	81.94562738	149.8174905	98.28935361	135.0627376	131.8953488	170.943314	200.4462209	688.9796512	510.2267442	265.1790698	176.3232558	170.7697674	304.0534884	105.7939535	123.7714471	223.7456672	140.9727036	204.3457539	262.5454939
C18_1_Ceramide	16.14596226	15.59864151	10.94641509	17.51426415	19.61232704	18.40263158	12.26842105	11.92763158	21.12894737	24.08245614	29.49822844	18.84843823	16.48181818	23.32811189	13.43902098	16.13806331	17.01586592	17.28595903	27.2794041	17.28595903	18.0743865	26.32372188	11.62322086	25.95296524	18.22268916	11.01338042	12.15984527	8.988772284	19.02643794	22.68536831	33.56900629	8.556447799	24.53821384	17.42304403	5.135693082	6.793070175	38.73640351	7.667763158	16.35789474	16.58508772	27.21613054	16.56634033	12.17118881	13.43902098	9.297435897	9.520782123	14.44998138	10.1960149	8.440409683	12.896946	23.17229039	13.97752556	30.77280164	16.05376278	20.20623722	11.44025563	12.68429196	14.87965018	7.122717793	4.04921628	10.58153459	28.36945912	3.338656604	6.677313208	17.97036478	14.1995614	30.10307018	3.055745614	17.49385965	16.92587719	32.54102564	9.297435897	14.79137529	10.98787879	13.69258741	11.34391061	13.23456238	16.27310987	26.6716946	40.71653631	22.98691207	23.54304703	19.2793456	19.65010225	10.02896728	10.06205853	12.31839892	11.48904137	10.54991591	16.22125799
C20_Ceramide	128.2232704	78.39937107	87.1918239	139.2138365	161.927673	111.974213	85.31368609	49.90850636	143.9668453	101.5232864	303.0824063	87.579007	118.0840544	104.3075814	74.78656778	150.7429505	160.5546218	186.4217554	203.3691877	173.0422035	110.9648531	174.6801559	89.05824341	139.8873052	113.2557404	92.60561224	87.49953839	83.55393586	149.7008017	163.6264577	361.2232704	64.69779874	188.3050314	144.3427673	30.0408805	33.80554811	163.1624246	63.55869614	82.00778075	138.6347399	115.131953	148.5891018	76.55782859	105.2916152	79.80514009	99.00868347	191.7735761	126.6597572	109.7123249	122.1999066	72.44931055	88.19916067	177.543765	132.7282824	114.687545	55.81867104	101.7733358	97.13145044	67.19129009	23.90570943	94.51886792	262.3081761	35.09654088	97.44968553	141.4119497	129.0369502	94.48490735	26.23395847	133.3026345	120.5055816	293.2420684	48.21765554	113.1638855	69.76799547	85.61093943	99.90065359	173.9341737	145.3911298	319.3253035	369.2756303	168.9529376	102.5172062	91.92185252	167.5211331	61.71077638	72.06526968	138.0960884	99.33634597	102.00543	156.6636297
C24_Ceramide	3071.986532	1963.299663	2548.439955	2771.717172	2502.244669	3515.323383	2138.772803	1036.394693	3822.487562	2081.890547	5926.756931	2158.401032	2600.696325	2547.62089	2149.555126	3083.614275	4406.651481	2052.270311	5323.40167	2979.438117	2202.494888	3577.300613	2090.265849	2216.523517	1921.92229	1491.731044	2178.712446	1678.197425	3336.76681	2581.087268	1547.542088	469.6520763	2201.975309	2340.561167	448.8641975	728.092869	1717.844113	596.1260365	1097.827529	1695.091211	1716.105738	719.172147	624.5209542	2061.096067	1273.810445	927.1678056	1791.829916	1156.355353	1343.872437	930.2930904	707.0429448	531.6850716	1697.464213	1795.664622	613.0511247	621.2274678	1050.100143	877.3733906	468.1287554	453.4077253	597.4590348	1924.803591	556.6531987	823.8159371	2047.991021	1581.3267	1051.18408	340.1558872	1058.00995	845.2703151	3405.673759	675.8272083	2370.702772	1052.662798	1300.348162	1760.577069	2812.756264	2177.281701	2771.085801	4156.628702	1697.464213	705.6400818	1262.576687	918.8752556	662.1513292	981.4020029	1413.218884	1334.706724	978.4577969	869.5221745
C24_1_Ceramide	1349.791022	1108.161765	707.3904799	841.5363777	1124.825851	1132.726333	953.5048966	729.7709467	1125.698041	700.4863983	2676.836266	1046.025249	897.7697016	789.0489671	812.1109411	1147.231571	1052.347756	1017.844551	1500.889423	1630.276442	749.1959554	1123.043236	624.5801953	795.7391911	463.9309623	665.0917008	650.7530738	502.954918	1411.803279	1191.209016	2807.898607	719.8885449	1683.072755	1758.061146	644.0669505	698.1436344	1757.072905	838.7094668	1153.811208	1815.642002	1474.319051	1235.462892	1004.843152	1400.191278	1153.098699	814.275641	1768.289263	2061.566506	1440.508814	1216.237981	1034.460948	882.8200837	1906.771269	1071.995816	687.6387727	644.1352459	1202.23873	1158.119877	815.0957992	340.8181352	714.0561146	3349.481424	452.4299536	941.5208978	1074.833591	1569.651795	1593.079434	372.4994559	1300.23395	928.905876	4315.883703	873.0604438	1153.098699	848.3511859	971.8974751	940.2123397	1811.418269	1940.805288	2277.211538	3234.675481	1216.129707	1177.093445	539.0006974	1214.628312	668.1206416	751.1234631	1466.951844	905.5394467	712.5194672	1367.684426
18_0_SM	17175.33776	16644.14175	12748.70432	14342.29236	13102.83499	12272.25877	11465.79605	12389.13743	11115.16009	11465.79605	13081.90909	13081.90909	11810.05682	10295.94697	9750.867424	13783.62069	13416.05747	12956.60345	24351.06322	16448.45402	16419.48773	17600.47177	9828.834882	11219.34834	11371.73338	7195.05	13457.40833	8047.796667	13017.71083	16921.69167	9118.864895	7684.635659	11774.84496	9472.99557	2965.844408	6720.522661	7433.482456	3962.186404	7702.303363	7445.170322	8781.837121	5953.479924	3791.331061	6722.647727	3688.371591	4511.838506	11762.02299	11578.24138	8426.386782	4824.267241	6476.36407	5314.428163	14628.96355	9124.054086	6228.738385	5849.309167	5982.550833	3917.305	3957.2775	3371.014167	7976.793466	14342.29236	6516.00443	8056.472868	13191.36766	9911.309942	8017.875731	2711.584795	5645.239035	5493.296784	12657.95833	6480.390152	8721.272727	7328.291667	6298.69697	12221.47701	23432.15517	18102.48851	24167.28161	16172.78161	18933.84084	3600.096497	8000.214439	8990.717179	3904.866571	6715.38	10219.63583	10046.42167	12578.01333	8247.659167
18_1_SM	8177.067869	9100.450689	5858.351007	6802.253446	5591.59597	6961.280488	5698.810976	7020.27439	5474.634146	6737.103659	6412.644788	6661.679537	5534.797297	5802.509653	4681.853282	6822.573937	8324.792052	7072.943623	14128.0037	8002.88817	5516.738014	6958.047945	3180.821918	4622.131849	4241.09589	2754.19708	5202.372263	2730.656934	5296.532847	7509.306569	3365.217391	2144.300106	6104.586426	4165.482503	980.8377519	2241.768293	3268.262195	1510.243902	3787.408537	3079.481707	4077.944015	1799.276062	1214.044402	2384.507722	989.9131274	1225.023105	6089.348429	4140.04159	2575.231054	1394.916821	2451.883562	1938.313356	5549.871575	2816.35274	2103.981164	1989.142336	2471.715328	1447.718978	1200.547445	919.2427007	3016.383881	4965.747614	2072.481442	2513.653234	5304.321315	3657.621951	4247.560976	849.5121951	2642.926829	2076.585366	4949.565637	2266.216216	3156.515444	2565.057915	3312.162162	4891.150647	8432.093346	8074.422366	6232.416821	8941.774492	5798.373288	1176.241438	3263.655822	2087.414384	1555.620719	2377.554745	2577.645985	3001.368613	3672.262774	2742.427007
16_0_SM	88702.44957	73674.75184	65965.73807	57280.89978	49669.46846	73647.91667	62335.22727	49637.31061	46982.29167	58064.10985	65529.14508	62568.49093	48817.89724	47699.42789	52107.51295	48512.27773	54447.29043	48426.26305	68123.62405	58662.0096	73218.00465	77827.37056	47689.20884	49639.32519	43966.25945	34556.88737	62967.75114	35716.51446	52878.99543	71548.99163	58354.30676	33763.52866	49767.05091	44595.18092	30152.97791	54947.34848	38555.49242	27589.10985	51830.58712	40979.64015	39672.76554	22764.14076	22632.55613	48817.89724	23224.68696	24944.25628	46791.98419	59694.18572	44899.6613	35266.0175	47334.64223	49284.75858	71267.88831	53184.99127	31556.42816	41514.64992	65982.78158	30266.26712	33629.18569	20989.25038	35129.683	49083.97374	46741.99488	34544.18828	51035.6228	48482.95455	45250.75758	25280.39773	26434.75379	29089.77273	74345.3152	31448.72625	50067.95121	28817.03368	36185.77288	44899.6613	55221.42252	56597.65735	49114.38047	44211.54389	72863.43805	21096.71321	31024.57824	40243.31006	20210.29668	36992.10426	47660.67352	39775.20928	40007.1347	37224.02968
24_0_SM	33700.19436	32639.69874	31107.87172	26865.88921	16850.09718	27429.92993	20875.87588	12865.36537	20390.39039	20997.24725	22130.1633	20383.04515	14966.97887	16714.09702	16189.96158	16946.19147	22368.97275	17115.65339	24487.24668	19742.31307	22575.07508	24941.81682	16949.51201	14673.7988	13144.51952	8980.220037	17710.67416	10024.69569	14872.42509	14758.89513	12843.78037	6186.22449	18735.42274	13197.27891	3912.050534	10377.25225	12258.50851	4527.152152	7452.202202	9224.224224	6522.574448	2841.978866	2294.548511	9958.573487	4018.371758	6592.068484	10252.44584	15759.95807	9744.060098	4278.913347	6590.465465	7336.899399	15110.73574	11232.92042	7009.196697	6686.914794	6584.737828	4507.139513	4268.726592	4529.845506	10051.14189	11017.37123	9308.794947	7258.503401	14257.77454	13472.22222	7209.459459	5194.694695	6262.762763	4794.169169	18111.79155	4228.025937	10715.65802	4950.168108	6930.235351	12624.91265	14743.18658	13556.95318	13980.60797	10337.1768	11688.06306	3404.466967	9303.115616	5825.825826	3641.141141	8106.039326	6527.972846	7901.685393	8435.276217	5710.557116
24_1_SM	69588.35759	87746.56965	47189.60499	40122.03742	35664.03326	36861.32723	36143.24943	43922.42563	27526.31579	39853.31808	40684.07367	47880.28169	30371.39762	27934.88624	36151.02925	32527.00491	36721.2766	34752.53682	48704.90998	45623.40426	40395.89552	42737.68657	26735.44776	27125.74627	18695.29851	21645.69378	33532.05742	18392.58373	36534.92823	37786.1244	44362.57796	28922.66112	42514.13721	33706.86071	21202.7027	36382.6087	25372.08238	16276.43021	24654.00458	24414.64531	25158.39653	13542.47021	12069.23077	24138.46154	13599.13326	12326.02291	28418.33061	53755.15548	30558.26514	12069.23077	23808.20896	26150	53275.74627	26735.44776	17992.76119	18142.3445	27025.83732	14388.75598	18392.58373	12111.57895	23051.14345	46537.21414	29248.85655	23159.87526	35337.83784	36741.6476	26329.51945	16994.50801	19747.13959	13882.83753	49636.8364	18018.85157	21531.961	18075.51463	21248.64572	26107.20131	43226.67758	46821.76759	38347.62684	28675.12275	33760.8209	15085.03731	12489.55224	22051.86567	10850.29851	20894.97608	23022.00957	24273.20574	23397.36842	24523.44498
SA	2.24	14.2	6.51	11.1	11	2.66	3.38	4.42	2.9	3.67	0.273	0.477	3.41	6	7.14	3.11	7.34	5.72	11.1	4.62	2.56	5.2	3.89	3.83	4	5.97	6.36	5.05	8.34	4	70.4	5.83	14.2	18.9	3.9	6.34	12.1	1.35	12.9	5.08	2.02	0.196	19.4	5.63	10.2	3.88	5.73	12.2	1.38	22.9	10.2	5.63	7.56	2.47	4.57	22.4	5.76	7.32	1.49	14.2	11.3	45.6	9.16	19.4	10.4	2.5	5.57	4.11	3.16	0.255	10.1	0.5	6.61	1.85	2.68	2.95	2.5	0.251	5.65	4.05	2.51	3.96	2.48	2.18	1.38	3.93	3.3	1.24	0.904	6.77
SO	12.81355932	15.27770535	17.68024772	17.37222947	29.32333768	7.617857143	11.8125	7.485267857	14.58482143	7.051339286	30.9244186	21.03488372	20.87790698	25.90116279	40.02906977	8.764411765	15.75	11.85882353	27.97941176	14.91617647	7.066468843	11.31476261	15.28264095	12.94117211	13.9787092	10.91761364	10.02272727	7.338068182	6.425284091	8.751988636	86.24511082	16.38657106	15.4625163	16.0785528	14.35365059	34.35267857	46.04464286	11.24598214	59.66517857	30.73660714	14.74011628	35.79069767	84.9244186	44.26744186	45.52325581	10.65441176	20.10441176	38.81911765	4.910294118	75.87794118	37.43545994	26.63946588	27.48071217	18.36721068	22.99406528	58.70454545	8.680397727	16.46590909	3.006818182	31.76846591	3.517568449	36.09973924	14.72327249	19.09713168	8.870925684	9.642857143	22.05803571	8.823214286	19.40625	13.74107143	65.30232558	22.60465116	27.94186047	11.31802326	8.147093023	8.643970588	3.418676471	4.558235294	23.43970588	12.6	14.00675074	11.30074184	15.00222552	21.87240356	10.26320475	6.174715909	5.252982955	1.503409091	4.358096591	24.78835227
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	HMDB_ID
C14_Ceramide	HMDB0011773
C16_Ceramide	HMDB0004949
C18_Ceramide	HMDB0004950
C18_1_Ceramide	HMDB0011774
C20_Ceramide	HMDB0004951
C24_Ceramide	HMDB0004956
C24_1_Ceramide	HMDB0004953
18_0_SM	HMDB0001348
18_1_SM	HMDB0012101
16_0_SM	HMDB0010169
24_0_SM	HMDB0011697
24_1_SM	HMDB0012107
SA	HMDB0000269
SO	HMDB0000252
METABOLITES_END
#END