#METABOLOMICS WORKBENCH hjyoo2_20231007_033452 DATATRACK_ID:4380 STUDY_ID:ST002924 ANALYSIS_ID:AN004795 PROJECT_ID:PR001816 VERSION 1 CREATED_ON October 11, 2023, 8:59 pm #PROJECT PR:PROJECT_TITLE Gut sphingolipid metabolites in infants with atopic dermatitis associated with PR:PROJECT_TITLE food allergy PR:PROJECT_SUMMARY This study determines S1P, ceradmides, sphingomyelins and diacylglycerols from PR:PROJECT_SUMMARY infant feces to explore differential sphingolipid metabolism associated with PR:PROJECT_SUMMARY food allergy in atopic dermatitis. PR:INSTITUTE Asan Medical Center PR:LAST_NAME Yoo PR:FIRST_NAME Hyun Ju PR:ADDRESS 88, Olympic-ro, 43-gil, Songpa-gu, Seoul, Seoul, 05505, Korea, South PR:EMAIL yoohyunju@amc.seoul.kr PR:PHONE 02-3010-4029 #STUDY ST:STUDY_TITLE Gut sphingolipid metabolites in infants with atopic dermatitis associated with ST:STUDY_TITLE food allergy - Part 2 ST:STUDY_SUMMARY This study determines sphingolipids and diacylglycerols from infant feces to ST:STUDY_SUMMARY explore the lipid changes with food allergy in atopic dermatitis. Food allergy ST:STUDY_SUMMARY (FA) may be present in the range of 20–80% in atopic dermatitis (AD). Food ST:STUDY_SUMMARY sensitization through the skin can cause FA due to damage to the skin barrier, ST:STUDY_SUMMARY and failure to acquire tolerance to food allergens in the gut can equally cause ST:STUDY_SUMMARY the development of FA. Gut metabolites can influence the physical gut barrier ST:STUDY_SUMMARY and intestinal homeostasis. Therefore, it is possible that gut metabolites ST:STUDY_SUMMARY related to gut immunity play an important role in the development of FA. ST:STUDY_SUMMARY Sphingolipids are key factors in cell inflammatory response and affect gut ST:STUDY_SUMMARY epithelial cells and skin barrier integrity and function. FA is associated with ST:STUDY_SUMMARY a marked decrease in serum sphingolipid levels. However, there are no reports of ST:STUDY_SUMMARY FA-associated gut sphingolipid metabolites in infants by targeted metabolomics. ST:STUDY_SUMMARY In our previous study, we showed that when FA is present in various phenotypes ST:STUDY_SUMMARY of AD in early life, it might be associated with the later development of ST:STUDY_SUMMARY asthma. The discovery of a biomarker that can distinguish the phenotypes that ST:STUDY_SUMMARY accompany AD and FA from other AD phenotypes is therefore expedient. ST:STUDY_SUMMARY Consequently, we aimed to investigate whether FA in AD infants. can be ST:STUDY_SUMMARY classified as gut sphingolipid metabolites using targeted metabolomics. ST:INSTITUTE Asan Medical Center ST:LAST_NAME Yoo ST:FIRST_NAME Hyun Ju ST:ADDRESS 88, Olympic-ro, 43-gil, Songpa-gu, Seoul, Seoul, 05505, Korea, South ST:EMAIL yoohyunju@amc.seoul.kr ST:PHONE 02-3010-4029 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER Not applicable SU:HUMAN_RACE Pacific asian #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 1_AD_human feces_child_1_2_dilu s_AD_1 Factor:AD Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 4_AD_human feces_child_1_2_dilu s_AD_2 Factor:AD Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 10_AD_human feces_child_1_2_dilu s_AD_3 Factor:AD Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 13_AD_child_1_2_dilu s_AD_4 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 24_AD_child_1_2_dilu s_AD_5 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 25_AD_child_1_2_dilu s_AD_6 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 33_AD_child_1_2_dilu s_AD_7 Factor:AD Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 39_AD_child_1_2_dilu s_AD_8 Factor:AD Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 41_AD_child_1_2_dilu s_AD_9 Factor:AD Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 46_AD_child_1_2_dilu s_AD_10 Factor:AD Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 51_AD_child_1_2_dilu s_AD_12 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 53_AD_child_1_2_dilu s_AD_13 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 55_AD_child_1_2_dilu s_AD_14 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 56_AD_child_1_2_dilu s_AD_15 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 57_AD_child_1_2_dilu s_AD_16 Factor:AD Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 62_AD_child_1_2_dilu s_AD_11 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 64_AD_child_1_2_dilu s_AD_17 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 66_AD_child_1_2_dilu s_AD_18 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 68_AD_child_1_2_dilu s_AD_19 Factor:AD Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 11_mild AD_1/3 dilu s_AD_20 Factor:AD Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 12_moderate AD_1/3 dilu s_AD_21 Factor:AD Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 17_severe AD_1/3 dilu s_AD_22 Factor:AD Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 25_mild AD_1/3 dilu s_AD_23 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 33_mild_AD_1/3 dilu s_AD_24 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 34_mild AD_1/3 dilu s_AD_25 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 36_mild AD_1/3 dilu s_AD_26 Factor:AD Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 47_moderate AD_1/3 dilu s_AD_27 Factor:AD Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 53_mild_AD_1/3 dilu s_AD_28 Factor:AD Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 66_mild AD_1/3 dilu s_AD_29 Factor:AD Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 78_moderate AD_1/3 dilu s_AD_30 Factor:AD Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 3_AD_human feces_child_1_2_dilu s_AD_FA_1 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 7_AD_human feces_child_1_2_dilu s_AD_FA_2 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 1_Disease_1/30 s_AD_FA_45 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 2_Disease_1/30 s_AD_FA_46 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 3_Disease_1/30 s_AD_FA_47 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 4_Disease_1/30 s_AD_FA_48 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 5_Disease_1/30 s_AD_FA_49 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 6_Disease_1/30 s_AD_FA_50 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 7_Disease_1/30 s_AD_FA_51 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 8_Disease_1/30 s_AD_FA_52 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 9_Disease_1/30 s_AD_FA_53 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 10_Disease_1/30 s_AD_FA_54 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 11_Disease_1/30 s_AD_FA_55 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 12_Disease_1/30 s_AD_FA_56 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 13_Disease_1/30 s_AD_FA_57 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 14_Disease_1/30 s_AD_FA_58 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 15_Disease_1/30 s_AD_FA_59 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 16_Disease_1/30 s_AD_FA_60 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 17_Disease_1/30 s_AD_FA_61 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 18_Disease_1/30 s_AD_FA_62 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 19_Disease_1/30 s_AD_FA_63 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 20_Disease_1/30 s_AD_FA_64 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 21_Disease_1/30 s_AD_FA_65 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 22_Disease_1/30 s_AD_FA_66 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 23_Disease_1/30 s_AD_FA_67 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 24_Disease_1/30 s_AD_FA_68 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 25_Disease_1/30 s_AD_FA_69 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 26_Disease_1/30 s_AD_FA_70 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 27_Disease_1/30 s_AD_FA_71 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 28_Disease_1/30 s_AD_FA_72 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 30_Disease_1/30 s_AD_FA_73 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 31_Disease_1/30 s_AD_FA_74 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 32_Disease_1/30 s_AD_FA_75 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 33_Disease_1/30 s_AD_FA_76 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 34_Disease_1/30 s_AD_FA_77 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 35_Disease_1/30 s_AD_FA_78 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 36_Disease_1/30 s_AD_FA_79 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 37_Disease_1/30 s_AD_FA_80 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 38_Disease_1/30 s_AD_FA_81 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 39_Disease_1/30 s_AD_FA_82 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 61_Disease_1/30 s_AD_FA_83 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 16_AD_child_1_2_dilu s_AD_FA_3 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 35_AD_child_1_2_dilu s_AD_FA_4 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 38_AD_child_1_2_dilu s_AD_FA_5 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 42_AD_child_1_2_dilu s_AD_FA_6 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 45_AD_child_1_2_dilu s_AD_FA_7 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 54_AD_child_1_2_dilu s_AD_FA_8 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 63_AD_child_1_2_dilu s_AD_FA_9 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 67_AD_child_1_2_dilu s_AD_FA_10 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 5_moderate AD_1/3 dilu s_AD_FA_11 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 6_moderate AD_1/3 dilu s_AD_FA_12 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 13_moderate AD_1/3 dilu s_AD_FA_13 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 14_mild AD_1/3 dilu s_AD_FA_14 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 19_severe AD_1/3 dilu s_AD_FA_15 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 28_mild AD_1/3 dilu s_AD_FA_16 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 30_mild AD_1/3 dilu s_AD_FA_17 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 31_moderate AD_1/3 dilu s_AD_FA_18 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 35_moderate AD_1/3 dilu s_AD_FA_19 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 37_moderate AD_1/3 dilu s_AD_FA_20 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 38_mild AD_1/3 dilu s_AD_FA_21 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 39_moderate AD_1/3 dilu s_AD_FA_22 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 40_mild AD_1/3 dilu s_AD_FA_23 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 46_mild AD_1/3 dilu s_AD_FA_24 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 48_severe AD_1/3 dilu s_AD_FA_25 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 49_moderate AD_1/3 dilu s_AD_FA_26 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 51_severe AD_1/3 dilu s_AD_FA_27 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 54_severe AD_1/3 dilu s_AD_FA_28 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 55_mild AD_1/3 dilu s_AD_FA_29 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 56_moderate AD_1/3 dilu s_AD_FA_30 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 57_severe AD_1/3 dilu s_AD_FA_31 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 58_severe AD_1/3 dilu s_AD_FA_32 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 60_moderate AD_1/3 dilu s_AD_FA_33 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 65_moderate AD_1/3 dilu s_AD_FA_34 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 68_moderate AD_1/3 dilu s_AD_FA_35 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 69_severe AD_1/3 dilu s_AD_FA_36 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 70_moderate AD_1/3 dilu s_AD_FA_37 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 71_mild AD_1/3 dilu s_AD_FA_38 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 73_mild_AD_1/3 dilu s_AD_FA_39 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 75_moderate AD_1/3 dilu s_AD_FA_40 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 76_moderate AD_1/3 dilu s_AD_FA_41 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 77_mild AD_1/3 dilu s_AD_FA_42 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 79_severe AD_1/3 dilu s_AD_FA_43 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 80_mild AD_1/3 dilu s_AD_FA_44 Factor:AD_FA Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 5_control_human feces_child_1_2_dilu s_Con_1 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 9_control_human feces_child_1_2_dilu s_Con_2 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 11_control_human feces_child_1_2_dilu s_Con_3 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 14_control_human feces_child_1_2_dilu s_Con_4 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 15_control_human feces_child_1_2_dilu s_Con_5 Factor:Con Subject=Cer_SM_SA_SO; Batch=set1; RAW_FILE_NAME=Cer_SM_SA_SO_set1.rdb SUBJECT_SAMPLE_FACTORS 41_Control_1/30 s_Con_27 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 43_Control_1/30 s_Con_28 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 44_Control_1/30 s_Con_29 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 45_Control_1/30 s_Con_30 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 48_Control_1/30 s_Con_31 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 49_Control_1/30 s_Con_32 Factor:Con Subject=Cer_SM_SA_SO; Batch=set10; RAW_FILE_NAME=Cer_SM_SA_SO_set10.rdb SUBJECT_SAMPLE_FACTORS 50_Control_1/30 s_Con_33 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 51_Control_1/30 s_Con_34 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 52_Control_1/30 s_Con_35 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 53_Control_1/30 s_Con_36 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 54_Control_1/30 s_Con_37 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 55_Control_1/30 s_Con_38 Factor:Con Subject=Cer_SM_SA_SO; Batch=set11; RAW_FILE_NAME=Cer_SM_SA_SO_set11.rdb SUBJECT_SAMPLE_FACTORS 56_Control_1/30 s_Con_39 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 57_Control_1/30 s_Con_40 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 58_Control_1/30 s_Con_41 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 59_Control_1/30 s_Con_42 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 60_Control_1/30 s_Con_43 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 62_Control_1/30 s_Con_44 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 63_Control_1/30 s_Con_45 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 64_Control_1/30 s_Con_46 Factor:Con Subject=Cer_SM_SA_SO; Batch=set12; RAW_FILE_NAME=Cer_SM_SA_SO_set12.rdb SUBJECT_SAMPLE_FACTORS 18_control_child_1_2_dilu s_Con_6 Factor:Con Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 22_control_child_1_2_dilu s_Con_7 Factor:Con Subject=Cer_SM_SA_SO; Batch=set2; RAW_FILE_NAME=Cer_SM_SA_SO_set2.rdb SUBJECT_SAMPLE_FACTORS 23_control_child_1_2_dilu s_Con_8 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 26_control_child_1_2_dilu s_Con_9 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 29_control_child_1_2_dilu s_Con_10 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 30_control_child_1_2_dilu s_Con_11 Factor:Con Subject=Cer_SM_SA_SO; Batch=set3; RAW_FILE_NAME=Cer_SM_SA_SO_set3.rdb SUBJECT_SAMPLE_FACTORS 31_control_child_1_2_dilu s_Con_12 Factor:Con Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 34_control_child_1_2_dilu s_Con_13 Factor:Con Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 43_control_child_1_2_dilu s_Con_14 Factor:Con Subject=Cer_SM_SA_SO; Batch=set4; RAW_FILE_NAME=Cer_SM_SA_SO_set4.rdb SUBJECT_SAMPLE_FACTORS 58_control_child_1_2_dilu s_Con_15 Factor:Con Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 59_control_child_1_2_dilu s_Con_16 Factor:Con Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 60_control_child_1_2_dilu s_Con_17 Factor:Con Subject=Cer_SM_SA_SO; Batch=set5; RAW_FILE_NAME=Cer_SM_SA_SO_set5.rdb SUBJECT_SAMPLE_FACTORS 1_control_1/3 dilu s_Con_19 Factor:Con Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 3_control_1/3 dilu s_Con_20 Factor:Con Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 4_control_1/3 dilu s_Con_21 Factor:Con Subject=Cer_SM_SA_SO; Batch=set6; RAW_FILE_NAME=Cer_SM_SA_SO_set6.rdb SUBJECT_SAMPLE_FACTORS 32_mild AD_1/3 dilu s_Con_18 Factor:Con Subject=Cer_SM_SA_SO; Batch=set7; RAW_FILE_NAME=Cer_SM_SA_SO_set7.rdb SUBJECT_SAMPLE_FACTORS 42_control_1/3 dilu s_Con_22 Factor:Con Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 43_control_1/3 dilu s_Con_23 Factor:Con Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 44_control_1/3 dilu s_Con_24 Factor:Con Subject=Cer_SM_SA_SO; Batch=set8; RAW_FILE_NAME=Cer_SM_SA_SO_set8.rdb SUBJECT_SAMPLE_FACTORS 61_control_1/3 dilu s_Con_25 Factor:Con Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 64_control_1/3 dilu s_Con_26 Factor:Con Subject=Cer_SM_SA_SO; Batch=set9; RAW_FILE_NAME=Cer_SM_SA_SO_set9.rdb SUBJECT_SAMPLE_FACTORS 1_AD_child d_AD_1 Factor:AD Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 4_AD_child d_AD_2 Factor:AD Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 10_AD_child d_AD_3 Factor:AD Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 13_AD_child d_AD_4 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 24_AD_child d_AD_5 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 25_AD_child d_AD_6 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 33_AD_child d_AD_7 Factor:AD Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 39_AD_child d_AD_8 Factor:AD Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 41_AD_child d_AD_9 Factor:AD Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 46_AD_child d_AD_10 Factor:AD Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 51_AD_child d_AD_12 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 53_AD_child d_AD_13 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 55_AD_child d_AD_14 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 56_AD_child d_AD_15 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 57_AD_child d_AD_16 Factor:AD Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 62_AD_child d_AD_11 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 64_AD_child d_AD_17 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 66_AD_child d_AD_18 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 68_AD_child d_AD_19 Factor:AD Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 11_mild AD d_AD_20 Factor:AD Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 12_moderate AD d_AD_21 Factor:AD Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 17_severe AD d_AD_22 Factor:AD Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 25_mild AD d_AD_23 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 33_mild AD d_AD_24 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 34_mild AD d_AD_25 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 36_mild AD d_AD_26 Factor:AD Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 47_moderate AD d_AD_27 Factor:AD Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 53_mild_AD d_AD_28 Factor:AD Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 66_mild AD d_AD_29 Factor:AD Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 78_moderate AD d_AD_30 Factor:AD Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 3_AD_child d_AD_FA_1 Factor:AD_FA Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 7_AD_child d_AD_FA_2 Factor:AD_FA Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 1_Disease d_AD_FA_45 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 2_Disease d_AD_FA_46 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 3_Disease d_AD_FA_47 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 4_Disease d_AD_FA_48 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 5_Disease d_AD_FA_49 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 6_Disease d_AD_FA_50 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 7_Disease d_AD_FA_51 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 8_Disease d_AD_FA_52 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 9_Disease d_AD_FA_53 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 10_Disease d_AD_FA_54 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 11_Disease d_AD_FA_55 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 12_Disease d_AD_FA_56 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 13_Disease d_AD_FA_57 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 14_Disease d_AD_FA_58 Factor:AD_FA Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 15_Disease d_AD_FA_59 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 16_Disease d_AD_FA_60 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 17_Disease d_AD_FA_61 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 18_Disease d_AD_FA_62 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 19_Disease d_AD_FA_63 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 20_Disease d_AD_FA_64 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 21_Disease d_AD_FA_65 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 22_Disease d_AD_FA_66 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 23_Disease d_AD_FA_67 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 24_Disease d_AD_FA_68 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 25_Disease d_AD_FA_69 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 26_Disease d_AD_FA_70 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 27_Disease d_AD_FA_71 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 28_Disease d_AD_FA_72 Factor:AD_FA Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 30_Disease d_AD_FA_73 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 31_Disease d_AD_FA_74 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 32_Disease d_AD_FA_75 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 33_Disease d_AD_FA_76 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 34_Disease d_AD_FA_77 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 35_Disease d_AD_FA_78 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 36_Disease d_AD_FA_79 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 37_Disease d_AD_FA_80 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 38_Disease d_AD_FA_81 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 39_Disease d_AD_FA_82 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 61_Disease d_AD_FA_83 Factor:AD_FA Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 16_AD_child d_AD_FA_3 Factor:AD_FA Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 35_AD_child d_AD_FA_4 Factor:AD_FA Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 38_AD_child d_AD_FA_5 Factor:AD_FA Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 42_AD_child d_AD_FA_6 Factor:AD_FA Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 45_AD_child d_AD_FA_7 Factor:AD_FA Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 54_AD_child d_AD_FA_8 Factor:AD_FA Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 63_AD_child d_AD_FA_9 Factor:AD_FA Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 67_AD_child d_AD_FA_10 Factor:AD_FA Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 5_moderate AD d_AD_FA_11 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 6_moderate AD d_AD_FA_12 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 13_moderate AD d_AD_FA_13 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 14_mild AD d_AD_FA_14 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 19_severe AD d_AD_FA_15 Factor:AD_FA Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 28_mild AD d_AD_FA_16 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 30_mild AD d_AD_FA_17 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 31_moderate AD d_AD_FA_18 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 35_moderate AD d_AD_FA_19 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 37_moderate AD d_AD_FA_20 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 38_mild AD d_AD_FA_21 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 39_moderate AD d_AD_FA_22 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 40_mild AD d_AD_FA_23 Factor:AD_FA Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 46_mild AD d_AD_FA_24 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 48_severe AD d_AD_FA_25 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 49_moderate AD d_AD_FA_26 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 51_severe AD d_AD_FA_27 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 54_severe AD d_AD_FA_28 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 55_mild AD d_AD_FA_29 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 56_moderate AD d_AD_FA_30 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 57_severe AD d_AD_FA_31 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 58_severe AD d_AD_FA_32 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 60_moderate AD d_AD_FA_33 Factor:AD_FA Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 65_moderate AD d_AD_FA_34 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 68_moderate AD d_AD_FA_35 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 69_severe AD d_AD_FA_36 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 70_moderate AD d_AD_FA_37 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 71_mild AD d_AD_FA_38 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 73_mild_AD d_AD_FA_39 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 75_moderate AD d_AD_FA_40 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 76_moderate AD d_AD_FA_41 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 77_mild AD d_AD_FA_42 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 79_severe AD d_AD_FA_43 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 80_mild AD d_AD_FA_44 Factor:AD_FA Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 5_control_child d_Con_1 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 9_control_child d_Con_2 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 11_control_child d_Con_3 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 14_control_child d_Con_4 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 15_control_child d_Con_5 Factor:Con Subject=DAG; Batch=set1; RAW_FILE_NAME=DAG_set1.rdb SUBJECT_SAMPLE_FACTORS 41_Control d_Con_27 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 43_Control d_Con_28 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 44_Control d_Con_29 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 45_Control d_Con_30 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 48_Control d_Con_31 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 49_Control d_Con_32 Factor:Con Subject=DAG; Batch=set10; RAW_FILE_NAME=DAG_set10.rdb SUBJECT_SAMPLE_FACTORS 50_Control d_Con_33 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 51_Control d_Con_34 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 52_Control d_Con_35 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 53_Control d_Con_36 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 54_Control d_Con_37 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 55_Control d_Con_38 Factor:Con Subject=DAG; Batch=set11; RAW_FILE_NAME=DAG_set11.rdb SUBJECT_SAMPLE_FACTORS 56_Control d_Con_39 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 57_Control d_Con_40 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 58_Control d_Con_41 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 59_Control d_Con_42 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 60_Control d_Con_43 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 62_Control d_Con_44 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 63_Control d_Con_45 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 64_Control d_Con_46 Factor:Con Subject=DAG; Batch=set12; RAW_FILE_NAME=DAG_set12.rdb SUBJECT_SAMPLE_FACTORS 18_control_child d_Con_6 Factor:Con Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 22_control_child d_Con_7 Factor:Con Subject=DAG; Batch=set2; RAW_FILE_NAME=DAG_set2.rdb SUBJECT_SAMPLE_FACTORS 23_control_child d_Con_8 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 26_control_child d_Con_9 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 29_control_child d_Con_10 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 30_control_child d_Con_11 Factor:Con Subject=DAG; Batch=set3; RAW_FILE_NAME=DAG_set3.rdb SUBJECT_SAMPLE_FACTORS 31_control_child d_Con_12 Factor:Con Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 34_control_child d_Con_13 Factor:Con Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 43_control_child d_Con_14 Factor:Con Subject=DAG; Batch=set4; RAW_FILE_NAME=DAG_set4.rdb SUBJECT_SAMPLE_FACTORS 58_control_child d_Con_15 Factor:Con Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 59_control_child d_Con_16 Factor:Con Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 60_control_child d_Con_17 Factor:Con Subject=DAG; Batch=set5; RAW_FILE_NAME=DAG_set5.rdb SUBJECT_SAMPLE_FACTORS 1_control d_Con_19 Factor:Con Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 3_control d_Con_20 Factor:Con Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 4_control d_Con_21 Factor:Con Subject=DAG; Batch=set6; RAW_FILE_NAME=DAG_set6.rdb SUBJECT_SAMPLE_FACTORS 32_mild AD d_Con_18 Factor:Con Subject=DAG; Batch=set7; RAW_FILE_NAME=DAG_set7.rdb SUBJECT_SAMPLE_FACTORS 42_control d_Con_22 Factor:Con Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 43_control d_Con_23 Factor:Con Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 44_control d_Con_24 Factor:Con Subject=DAG; Batch=set8; RAW_FILE_NAME=DAG_set8.rdb SUBJECT_SAMPLE_FACTORS 61_control d_Con_25 Factor:Con Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb SUBJECT_SAMPLE_FACTORS 64_control d_Con_26 Factor:Con Subject=DAG; Batch=set9; RAW_FILE_NAME=DAG_set9.rdb #COLLECTION CO:COLLECTION_SUMMARY The study population consisted of 158 six-month-old infants (46 healthy infants, CO:COLLECTION_SUMMARY 30 only AD group, and 82 with combined AD and FA) involved in the Cohort for CO:COLLECTION_SUMMARY Childhood Origin of Asthma and Allergic Diseases (COCOA) (reference: BMC Pulm CO:COLLECTION_SUMMARY Med 2014, 14:109.) CO:SAMPLE_TYPE Feces #TREATMENT TR:TREATMENT_SUMMARY no treatment #SAMPLEPREP SP:SAMPLEPREP_SUMMARY ~40 mg of feces was used and lipids were extracted by Bligh and Dyer method SP:SAMPLEPREP_SUMMARY after adding internal standard solutions (50 μl of 100 nM C18 ceramide-d7 and SP:SAMPLEPREP_SUMMARY C18:1 Sphingomyelin-d9 and 200 μl of 1 μM 1,3-19:0-d5). Organic solutions SP:SAMPLEPREP_SUMMARY containing the lipids were dried using a vacuum centrifuge and stored at SP:SAMPLEPREP_SUMMARY –20°C until LC-MS/MS analysis. The dried matter was reconstituted with SP:SAMPLEPREP_SUMMARY methanol and injected into the LC-MS/MS system. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY diacylglycerols CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity CH:COLUMN_NAME Agilent Pursuit 5 C18 (150 x 2.0 mm, 5um) CH:SOLVENT_A 5 mM ammonium formate/MeOH/tetrahydrofuran (500/200/300, v/v/v) CH:SOLVENT_B 5 mM ammonium formate/MeOH/ tetrahydrofuran (100/200/700, v/v/v) CH:FLOW_GRADIENT 90 % of B for 0 min, 90 % of B for 6 min, 90 to 95 % of B for 0.6 min, 95 % of B CH:FLOW_GRADIENT for 3.4 min, 95 to 90 % of B for 0.1 min, and 90 % of B for 1.9 min CH:FLOW_RATE 200 uL/min CH:COLUMN_TEMPERATURE 35 #ANALYSIS AN:ANALYSIS_TYPE MS AN:ACQUISITION_PARAMETERS_FILE MS_metadata.docx #MS MS:INSTRUMENT_NAME ABI Sciex 5500 QTrap MS:INSTRUMENT_TYPE QTRAP MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Multiple reaction monitoring (MRM) was performed in the positive ion mode and MS:MS_COMMENTS the extracted ion chromatogram corresponding to the specific transition for each MS:MS_COMMENTS lipid was used for quantification. The calibration range for each lipid was MS:MS_COMMENTS 0.1-1000 nM (r2 ≥ 0.99). Data analysis was performed by using Analyst 1.5.2 MS:MS_COMMENTS software. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS pmol/mg MS_METABOLITE_DATA_START Samples s_AD_1 s_AD_2 s_AD_3 s_AD_4 s_AD_5 s_AD_6 s_AD_7 s_AD_8 s_AD_9 s_AD_10 s_AD_11 s_AD_12 s_AD_13 s_AD_14 s_AD_15 s_AD_16 s_AD_17 s_AD_18 s_AD_19 s_AD_20 s_AD_21 s_AD_22 s_AD_23 s_AD_24 s_AD_25 s_AD_26 s_AD_27 s_AD_28 s_AD_29 s_AD_30 s_AD_FA_1 s_AD_FA_2 s_AD_FA_3 s_AD_FA_4 s_AD_FA_5 s_AD_FA_6 s_AD_FA_7 s_AD_FA_8 s_AD_FA_9 s_AD_FA_10 s_AD_FA_11 s_AD_FA_12 s_AD_FA_13 s_AD_FA_14 s_AD_FA_15 s_AD_FA_16 s_AD_FA_17 s_AD_FA_18 s_AD_FA_19 s_AD_FA_20 s_AD_FA_21 s_AD_FA_22 s_AD_FA_23 s_AD_FA_24 s_AD_FA_25 s_AD_FA_26 s_AD_FA_27 s_AD_FA_28 s_AD_FA_29 s_AD_FA_30 s_AD_FA_31 s_AD_FA_32 s_AD_FA_33 s_AD_FA_34 s_AD_FA_35 s_AD_FA_36 s_AD_FA_37 s_AD_FA_38 s_AD_FA_39 s_AD_FA_40 s_AD_FA_41 s_AD_FA_42 s_AD_FA_43 s_AD_FA_44 s_AD_FA_45 s_AD_FA_46 s_AD_FA_47 s_AD_FA_48 s_AD_FA_49 s_AD_FA_50 s_AD_FA_51 s_AD_FA_52 s_AD_FA_53 s_AD_FA_54 s_AD_FA_55 s_AD_FA_56 s_AD_FA_57 s_AD_FA_58 s_AD_FA_59 s_AD_FA_60 s_AD_FA_61 s_AD_FA_62 s_AD_FA_63 s_AD_FA_64 s_AD_FA_65 s_AD_FA_66 s_AD_FA_67 s_AD_FA_68 s_AD_FA_69 s_AD_FA_70 s_AD_FA_71 s_AD_FA_72 s_AD_FA_73 s_AD_FA_74 s_AD_FA_75 s_AD_FA_76 s_AD_FA_77 s_AD_FA_78 s_AD_FA_79 s_AD_FA_80 s_AD_FA_81 s_AD_FA_82 s_AD_FA_83 s_Con_1 s_Con_2 s_Con_3 s_Con_4 s_Con_5 s_Con_6 s_Con_7 s_Con_8 s_Con_9 s_Con_10 s_Con_11 s_Con_12 s_Con_13 s_Con_14 s_Con_15 s_Con_16 s_Con_17 s_Con_18 s_Con_19 s_Con_20 s_Con_21 s_Con_22 s_Con_23 s_Con_24 s_Con_25 s_Con_26 s_Con_27 s_Con_28 s_Con_29 s_Con_30 s_Con_31 s_Con_32 s_Con_33 s_Con_34 s_Con_35 s_Con_36 s_Con_37 s_Con_38 s_Con_39 s_Con_40 s_Con_41 s_Con_42 s_Con_43 s_Con_44 s_Con_45 s_Con_46 Factors Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:AD_FA Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con Factor:Con C16_0_16_0_DAG 9.744519146 17.40872316 12.90646717 6.65224894 8.11650049 7.753588517 4.827544844 5.859375 4.842105263 4.637931034 28.66626537 8.457037231 19.11526739 6.519125264 1.245767161 4.618453865 3.280871999 4.139431183 13.58322802 2.842016807 10.33035714 5.320928571 6.403682255 5.729479362 3.751121795 17.07501814 2.091836735 9.177083333 4.2453 10.9025 10.23512862 11.94914537 8.775395483 8.930042498 0.933333333 16.98275862 25.60606061 2.274238646 2.685504568 10.3678718 2.643993506 3.524068323 2.775952381 4.45 2.067516234 19.99537722 12.06037567 8.47503278 5.418213327 7.393352441 3.957932692 4.04059222 5.176473662 3.231707317 7.94 2.666666667 5.29787234 2.802083333 1.545454545 5.520833333 3.801886792 5 4.489583333 12.2375 3.591644444 7.468088889 12.93756098 4.6903 5.123304348 5.400595745 3.946297872 3.62408 7.2535 3.89944186 2.259599049 1.554281346 3.897808359 8.297247706 1.435168196 4.082342281 1.891284404 4.806783431 3.741896024 15.35705681 5.330275229 6.388019428 8.320081549 2.395174992 4.2 6.772093023 8.741025641 4.258333333 14.24705882 15.42058824 2.746153846 5.436666667 4.561290323 5.797435897 125.1025641 55.8 5.515151515 10.39347826 5.354806241 3.784874411 7.976430129 8.375047565 28.686462 6.479315551 12.71766482 4.254560896 4.99438659 3.574333166 3.739997484 3.853224891 13.02652733 1.152346649 11.67643906 8.246485089 11.04410009 16.619554 6.947368421 3.5859375 7.795081967 6.387931034 12.25510784 10.66549727 7.216334165 1.042712504 7.219553836 2.957744003 5.483035714 3.642642857 13.01832298 5.029827316 7.51 5.72 4.78 8.333636364 10.18325581 3.011984462 2.460207354 51.89286091 3.406345566 3.050458716 3.752392226 2.535909091 58.13043478 3.245454545 4.055882353 2.686486486 6.709756098 17.51467875 6.698862607 9.370910921 6.675417239 4.381205106 2.392201484 8.900556319 4.772626725 C16_0_18_1_DAG 3.548511628 9.017284321 1.553495874 6.337078842 3.677060724 2.346057258 2.592803199 2.703125 1.052631579 1.232758621 1.518699837 2.560855263 1.349698276 2.034011936 0.788861162 1.145815812 3.301104088 1.308776397 1.99311945 13.99663287 38.82074457 6.859909619 26.69638435 28.27770328 12.28881184 18.99688805 13.16326531 40.83333333 12.3490566 41.68238994 2.256118068 4.440403917 4.628362959 2.442413181 2.325 11.55172414 1.393939394 1.108365987 2.009911969 2.196808177 17.14977405 19.1921857 15.11168496 44.94566387 7.094899935 30.95020383 125.2335372 25.48291233 24.65646129 23.02929859 59.93065874 22.36255572 43.94125374 51.34146341 42.6 19.41176471 16.4893617 20.9375 11.26136364 12.08333333 19.43396226 18.13953488 9.135416667 32.60220126 10.9769392 25.82809224 29.56281638 16.18867925 61.36177194 7.630670413 7.242071457 14.94339623 26.46226415 39.19262835 15.21172016 8.892469136 12.17323045 37.61817284 10.04876543 18.1295839 8.93720679 31.30175832 15.7917037 33.63771044 18.05445094 64.16310821 35.16222655 11.22035665 13.35833333 18.72093023 34.1025641 23.52777778 43.02941176 50.64705882 26.92307692 29.86666667 28.4516129 29.25641026 195.6410256 92.6 22.48484848 22.52173913 29.5796727 20.16795866 44.53757537 33.94119871 84.70542636 38.58802756 51.71640827 26.47044574 26.3734844 16.27554264 20.79820736 2.492051984 6.801051567 1.699051878 1.902763338 2.939343365 6.007521619 3.774008775 1.412280702 1.6875 1.893442623 3.543103448 4.780263158 2.792544565 4.801094164 2.802366248 1.207448552 5.331176196 9.792769529 20.28147192 27.66441182 25.84023208 22.2 18 12.4 32.35849057 45.75691093 13.56304304 11.29974104 149.3881652 19.70521605 17.31691358 17.75474313 9.513636364 145.326087 23.48181818 32.94117647 NA 32.95121951 44.53757537 18.46578295 84.5709733 39.57280536 23.65151515 26.30603303 40.71747329 28.00063097 C18_0_C18_0_DAG 0.432443544 1.520957469 0.152095747 2.228276764 0.026685739 0.143928724 0.046213464 0.321875 0.062280702 0.04637931 0.632519157 0.237061404 0.087037037 0.42982906 0.058406433 0.115191396 2.572685311 1.681662885 1.572196579 0.265530076 5.155326877 1.800644068 1.623960348 6.469953295 4.161678487 7.163930149 0.719387755 13.33333333 1.385826271 9.610875706 0.236420056 0.360286065 0.203148602 0.588051643 0.128333333 0.668965517 0.481060606 0.130555556 1.290196078 4.662992126 1.02816641 1.315058954 2.827457627 0.705314266 1.826348228 10.68760229 10.53513112 8.746034816 5.234982682 3.296092471 2.635334347 0.929796905 0.785814061 0.925609756 1.39 1.431372549 12.44680851 3.5 0.722727273 4.864583333 2.462264151 12.20930233 8.34375 21.39194915 1.256647834 6.61393597 19.32761472 7.031440678 5.046720707 8.548864046 2.026397404 0.944966102 16.74152542 0.532094994 1.192270531 0.689813665 3.185597826 1.649804348 0.419157609 1.582242351 0.553288043 1.341304348 1.256993789 2.824868248 2.379050343 1.262404092 3.459153318 1.122721417 3.529166667 3.288372093 2.207692308 0.989722222 3.705882353 2.03 2.264230769 1.612333333 1.232903226 1.76974359 10.21282051 4.58 1.285454545 0.663478261 1.08327063 0.710527054 2.058214196 4.672595386 10.51546275 0.820035867 2.402539503 0.735777723 1.19118105 0.232524041 1.995587613 0.275296615 0.65979184 0.148434183 0.219141584 0.298580409 0.31395693 0.213518365 0.506140351 0.1421875 0.054344262 0.512068966 0.391666667 0.13940678 0.122521368 11.96225104 1.008062307 11.13550358 1.878771186 0.814010169 6.615733235 2.735410334 4.24 4.93 5.01 5.411402157 3.23582972 0.793907168 0.906198303 4.153418291 0.591012228 0.598796584 0.982180926 2.469090909 1.403043478 1.065909091 2.034117647 0.317837838 0.411463415 2.207163908 0.705859142 1.646571357 2.002586785 1.270381011 0.313677495 3.2278537 0.798093338 C18_1_18_1_DAG 1.350277454 3.407151713 1.024807351 1.291560539 2.293823551 0.706886909 1.316769821 1.275 0.519298246 0.494827586 0.681752874 0.791109475 0.667417767 1.223865878 0.384359792 0.617360282 0.542351097 0.494352851 1.175666144 12.41732409 70.88851742 2.043888389 11.93139337 146.894233 10.08805815 16.0271557 11.73469388 30.83333333 5.827328767 27.89497717 1.840762854 1.214953595 2.090016775 0.551333234 0.786666667 6.99137931 0.451515152 1.082856537 0.851016043 2.757678133 10.57057524 9.498728134 10.87212721 37.38411341 2.542058751 10.39036664 113.830689 25.16036534 31.736579 11.27408339 68.79728527 19.62192014 40.56481105 34.51219512 51.6 14.50980392 25.95744681 26.14583333 12.15909091 11.77083333 21.69811321 13.60465116 4.333333333 16.1586758 5.669710807 23.67671233 12.44570665 13.77739726 129.5652174 7.608510638 5.619527834 5.559945205 11.2260274 54.39757885 13.4699839 5.263586957 5.463783213 22.06927536 4.710235507 7.292042405 3.330230978 7.993126921 11.70405797 11.79501537 7.299408848 57.12936914 7.173442665 2.785252281 3.9375 4.330232558 8.417948718 72.13888889 154.8235294 19.49705882 21.26923077 16.66 16.21290323 10.60769231 54.02564103 27.2 7.021212121 NA 11.78572777 20.33256128 21.77530078 265.7324841 62.16242038 68.35230007 68.48938429 25.74283439 16.11429038 14.24990446 6.622551752 0.790382996 1.121154287 0.502242624 5.088545592 0.464360122 6.081402729 0.536204993 0.453508772 0.63984375 0.763934426 1.663793103 3.77642825 1.045494054 2.617894926 0.871022727 0.367885375 1.574898236 2.977317732 31.06066607 41.63346769 13.35685676 19.3 8.65 9.99 16.32876712 44.04969736 3.962828045 9.714757865 71.4097951 10.93543931 9.879347826 5.900093502 2.793636364 NA 24.78636364 NA 60.35135135 17.92682927 NA 5.899261146 NA 20.10948528 8.998668211 26.05333703 33.39610949 8.157369279 C18_0_18_2_DAG 2.06728065 33.80420268 1.00567503 4.988359846 0.26673482 3.083240976 0.236448424 1.0671875 0.628070175 0.145689655 2.217503748 1.201582761 1.398850242 1.381869565 0.365061022 3.149708378 1.380270851 1.162230954 3.400459372 2.149598357 22.56582976 1.131659522 14.12183544 46.35690028 61.08016878 9.751433007 1.112244898 75.9375 3.782348243 27.21445687 2.639978214 5.563682491 1.553835685 6.045045893 1.516666667 11.12068966 10.22727273 0.339044796 2.85551937 10.05363322 4.259797918 12.82342448 5.218207798 6.792904164 6.124464176 36.97237098 18.70032382 24.42246835 39.6106859 16.72894352 24.54113924 14.28797468 12.28419097 4.353658537 10.1 3.519607843 10.11702128 5.364583333 1.375 5.958333333 10.66037736 44.88372093 12.60416667 22.52496006 3.271884984 13.20234292 40.3210473 10.14776358 42.75698014 12.56202841 2.94422541 1.431757188 8.644049521 5.706776135 5.327366359 5.862405542 3.324302057 8.932670025 2.304061713 7.309576453 4.055966625 4.118143653 18.47612091 38.86787268 6.449363648 75.6739517 4.286181449 1.739028827 102.9583333 5.453488372 6.623076923 15.16666667 12.76470588 74.32352941 4.576923077 13.25333333 4.629032258 23.69230769 79.69230769 55 35.63636364 8.110869565 2.393934514 22.43917435 12.02777778 63.67196889 22.56142167 25.65925926 65.74189096 3.765217391 6.918989223 3.357318841 12.43306159 0.606155752 9.374419816 1.068082789 7.86975095 0.708894015 1.912148127 3.371676842 0.231578947 1.1171875 0.267213115 2.025862069 64.39016018 1.222881356 7.782065217 2.043736007 0.935297879 28.19475288 4.438227189 8.416717697 23.06371309 13.72513562 11.9 5.66 25.1 10.31549521 15.10364812 4.869739261 10.76315046 51.07391644 4.795584068 4.253652393 8.102697652 24.65909091 35.60869565 4.518181818 38.29411765 3.027027027 8.707317073 19.69766506 8.534492754 9.440933977 7.021621622 3.194729908 9.003780718 46.47160204 7.720155039 C18_0_20_4_DAG 0.005188579 0.036394009 6.85E-05 0.006959638 0.001918542 0.003119789 0.001867469 0.0030625 0.001438596 0.001793103 0.003550486 0.001563739 0.003606305 0.001361821 0.001143147 0.000676182 0.000467219 0.001983051 0.002759066 0.047629655 0.069666103 0.050514497 1.153870101 0.115994779 0.144481537 0.120696531 0.061428571 0.07875 0.055983881 0.173837874 0.011372899 0.011216165 0.01052161 0.013500573 0.000908333 0.008456897 0.01030303 0.003883856 0.001835294 0.000842563 0.341907612 0.24903203 0.084957594 0.026453402 0.086574771 0.097097968 0.080067017 0.52852647 0.041089159 0.243080666 0.121047904 0.212680321 0.08547237 0.04 0.0218 0.204901961 0.032765957 0.010625 0.05125 0.088854167 0.042641509 0.512790698 0.042083333 0.158475458 0.225962285 0.105219079 0.315215495 0.060641119 0.085213955 0.042113322 0.028240698 0.104011647 0.044631864 0.032582614 0.222035905 0.503920774 0.447259825 0.083983581 0.075467561 0.187530325 0.155275109 0.306867805 0.106474361 0.431660712 0.151011262 0.202532751 0.236880411 0.070261362 1.735416667 0.147488372 0.351794872 0.182 0.547647059 0.1015 0.054384615 0.620666667 0.151064516 0.513333333 1.434102564 0.794 0.277878788 0.467173913 0.355277676 0.181788577 0.303580925 0.341890712 0.700027442 0.104009465 0.214957922 0.040463707 0.321349039 0.165715587 0.261714805 0.001518166 0.007999132 0.001545693 0.002009763 0.002414607 0.003038568 0.002198671 0.002447368 0.001703125 0.001229508 0.004525862 0.009274588 0.003813292 0.002494308 0.001243264 ND 0.001791334 0.041922892 0.071493195 0.038854997 0.149647134 0.125 0.0594 0.0831 0.106728369 0.342072321 0.081560486 0.633943977 1.585342569 0.45569869 0.51356519 0.298354698 0.235136364 0.820217391 0.451818182 0.599117647 0.255405405 0.568536585 1.407361568 0.489425247 0.541165996 0.372430652 0.417573762 0.06172047 0.370825348 0.262448625 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name annotation HMDB_ID C16_0_16_0_DAG DG(16:0/16:0) HMDB0007098 C16_0_18_1_DAG DG(16:0/18:1) HMDB0007102 C18_0_C18_0_DAG DG(18:0/18:0) HMDB0007158 C18_1_18_1_DAG DG(18:1/18:1) HMDB0007159 C18_0_18_2_DAG DG(18:0/18:2) HMDB0007161 C18_0_20_4_DAG DG(18:0/20:4) HMDB0007170 METABOLITES_END #END