#METABOLOMICS WORKBENCH araskind_20240115_114015 DATATRACK_ID:4570 STUDY_ID:ST003060 ANALYSIS_ID:AN005015 PROJECT_ID:PR001906
VERSION             	1
CREATED_ON             	January 30, 2024, 5:25 pm
#PROJECT
PR:PROJECT_TITLE                 	Investigation of metabolism in ER+ breast cancer
PR:PROJECT_TYPE                  	MS
PR:PROJECT_SUMMARY               	This study aims to observe alterations in substrate preference in ER+ breast
PR:PROJECT_SUMMARY               	cancer cell lines when subjected to endocrine therapy
PR:INSTITUTE                     	University of Michigan
PR:DEPARTMENT                    	MRC2
PR:LABORATORY                    	BRCF metabolomics core
PR:LAST_NAME                     	Kachman
PR:FIRST_NAME                    	Maureen
PR:ADDRESS                       	Ann Arbor, MI, USA
PR:EMAIL                         	mkachman@med.umich.edu
PR:PHONE                         	734-232-0842
#STUDY
ST:STUDY_TITLE                   	Fluxomics of hormone deprivation in ER+ breast cancer cell lines
ST:STUDY_TYPE                    	Fluxomics
ST:STUDY_SUMMARY                 	Despite adjuvant treatment with endocrine therapies, estrogen receptor-positive
ST:STUDY_SUMMARY                 	(ER+) breast cancers recur in a significant proportion of patients. Recurrences
ST:STUDY_SUMMARY                 	are attributable to clinically undetectable endocrine-tolerant persister cancer
ST:STUDY_SUMMARY                 	cells that retain tumor-forming potential. We observed that persistence occurred
ST:STUDY_SUMMARY                 	stochastically without genetic predisposition. Genome-wide screening in
ST:STUDY_SUMMARY                 	persisters revealed a survival mechanism involving metabolic reprogramming with
ST:STUDY_SUMMARY                 	reliance upon mitochondrial respiration. Proteomic profiling showed reduced
ST:STUDY_SUMMARY                 	levels of glycolytic proteins in persisters. Metabolic tracing of glucose
ST:STUDY_SUMMARY                 	revealed an energy-depleted state in persisters where oxidative phosphorylation
ST:STUDY_SUMMARY                 	was required to generate ATP. Persisters exhibiting residual proliferation in
ST:STUDY_SUMMARY                 	human breast tumors following neoadjuvant endocrine therapy showed increased
ST:STUDY_SUMMARY                 	mitochondrial content. Pharmacological inhibition of oxidative phosphorylation
ST:STUDY_SUMMARY                 	suppressed the tumor-forming potential of persisters and synergized with the
ST:STUDY_SUMMARY                 	anti-estrogen fulvestrant to induce regression of patient-derived xenografts,
ST:STUDY_SUMMARY                 	supporting therapeutic targeting of mitochondrial metabolism to help eradicate
ST:STUDY_SUMMARY                 	residual disease.
ST:INSTITUTE                     	Dartmouth College
ST:DEPARTMENT                    	Molecular and Systems Biology
ST:LABORATORY                    	Miller
ST:LAST_NAME                     	Miller
ST:FIRST_NAME                    	Todd
ST:ADDRESS                       	Hanover, NH
ST:EMAIL                         	Todd.W.Miller@Dartmouth.edu
ST:PHONE                         	603-646-5507
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 glucose_1	13C label:glucose | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064226-MCF7_E2_glucose_1-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 glucose_2	13C label:glucose | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064227-MCF7_E2_glucose_2-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 glucose_3	13C label:glucose | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064228-MCF7_E2_glucose_3-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD glucose_1	13C label:glucose | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064229-MCF7_HD_glucose_1-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD glucose_2	13C label:glucose | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064230-MCF7_HD_glucose_2-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD glucose_3	13C label:glucose | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064231-MCF7_HD_glucose_3-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 oleic acid_1	13C label:oleic acid | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064232-MCF7_E2_oleic_acid_1-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 oleic acid_2	13C label:oleic acid | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064233-MCF7_E2_oleic_acid_2-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 oleic acid_3	13C label:oleic acid | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064234-MCF7_E2_oleic_acid_3-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD oleic acid_1	13C label:oleic acid | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064235-MCF7_HD_oleic_acid_1-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD oleic acid_2	13C label:oleic acid | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064236-MCF7_HD_oleic_acid_2-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD oleic acid_3	13C label:oleic acid | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064237-MCF7_HD_oleic_acid_3-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 glucose non-labeled control	13C label:glucose | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064238-MCF7_E2_glucose_non_labeled_ctrl-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 E2 oleic acid non-labeled control	13C label:oleic acid | Hormone treatment:Yes	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064239-MCF7_E2_oleic_acid_non_labeled_ctrl-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD glucose non-labeled control	13C label:glucose | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064240-MCF7_HD_glucose_non_labeled_ctrl-N.d
SUBJECT_SAMPLE_FACTORS           	-	MCF7 HD oleic acid non-labeled control	13C label:oleic acid | Hormone treatment:No	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-S00064241-MCF7_HD_oleic_acid_non_labeled_ctrl-N.d
SUBJECT_SAMPLE_FACTORS           	-	Pool	13C label:Pool | Hormone treatment:Pool	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-CS00000MP-01-N,20230109-EX01286-A045-IN0030-CS00000MP-02-N,20230109-EX01286-A045-IN0030-CS00000MP-03-N,20230109-EX01286-A045-IN0030-CS00000MP-04-N,20230109-EX01286-A045-IN0030-CS00000MP-05-N
SUBJECT_SAMPLE_FACTORS           	-	Blank	13C label:Blank | Hormone treatment:Blank	RAW_FILE_NAME=20230109-EX01286-A045-IN0030-CS00000SB-01-N,20230109-EX01286-A045-IN0030-CS00000SB-02-N,20230109-EX01286-A045-IN0030-CS00000SB-03-N,20230109-EX01286-A045-IN0030-CS00000SB-04-N,20230109-EX01286-A045-IN0030-CS00000SB-05-N,20230109-EX01286-A045-IN0030-CS00000SB-06-N
#COLLECTION
CO:COLLECTION_SUMMARY            	Cells were washed with 150 mM ammonium acetate and flash frozen, before storage
CO:COLLECTION_SUMMARY            	at -80deg C.
CO:SAMPLE_TYPE                   	Breast cancer cells
#TREATMENT
TR:TREATMENT_SUMMARY             	Cells are hormone deprived for 21 days, before reseeding into 10 cm dishes at
TR:TREATMENT_SUMMARY             	3-5e6 cells/dish. After 2 days of allowing the cells to properly adhere, cells
TR:TREATMENT_SUMMARY             	were labeled with 4.5 g/L 13C-glucose or 100 uM 13C-oleic acid according to the
TR:TREATMENT_SUMMARY             	sample preparation guidelines.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Glycolysis-TCA (GlyTCA) by Ion Pairing UPLC-QTOF mass spectrometry
SP:SAMPLEPREP_PROTOCOL_FILENAME  	GlyTCA_SOP_QTOF-with-prep-V1_20240118.pdf
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Ion Pairing UPLC
CH:CHROMATOGRAPHY_TYPE           	Ion pair
CH:INSTRUMENT_NAME               	Agilent 1290 Infinity II
CH:COLUMN_NAME                   	Agilent ZORBAX RRHD Extend-C18 (150 x 2.1mm, 1.8um, 80Å)
CH:SOLVENT_A                     	97% water, 3% methanol, 5mM tributylamine, 5.5mM acetic acid, 12.5nM medronic
CH:SOLVENT_A                     	acid
CH:SOLVENT_B                     	100% methanol, 5mM tributylamine, 5.5mM acetic acid, 12.5nM medronic acid
CH:SOLVENT_C                     	100% Acetonitrile
CH:FLOW_GRADIENT                 	(Time PercentA PercentB PercentC Flow) (2 100 0 0 0.25) (12 1 99 0 0.25) (19.5 1
CH:FLOW_GRADIENT                 	99 0 0.25) (20 5 0 95 0.5) (21 5 0 95 0.8) (22 5 0 95 0.8) (26 5 0 95 0.6) (26.1
CH:FLOW_GRADIENT                 	5 0 95 0.4) (26.2 100 0 0 0.4) (31.8 100 0 0 0.25) (32 100 0 0 0.25)
CH:FLOW_RATE                     	0.25 ml/min
CH:COLUMN_TEMPERATURE            	35
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
AN:ACQUISITION_PARAMETERS_FILE   	M001_30min_profile_MS1_10ul_WBsensON_AcqMethodReport.pdf
#MS
MS:INSTRUMENT_NAME               	Agilent 6545 QTOF
MS:INSTRUMENT_TYPE               	QTOF
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	All data acquisition and processing done using vendor software (Agilent)
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	counts
MS_METABOLITE_DATA_START
Samples	MCF7 E2 glucose_1	MCF7 E2 glucose_2	MCF7 E2 glucose_3	MCF7 HD glucose_1	MCF7 HD glucose_2	MCF7 HD glucose_3	MCF7 E2 oleic acid_1	MCF7 E2 oleic acid_2	MCF7 E2 oleic acid_3	MCF7 HD oleic acid_1	MCF7 HD oleic acid_2	MCF7 HD oleic acid_3	MCF7 E2 glucose non-labeled control	MCF7 E2 oleic acid non-labeled control	MCF7 HD glucose non-labeled control	MCF7 HD oleic acid non-labeled control	Pool	Pool	Pool	Pool	Pool
Factors	13C label:glucose | Hormone treatment:Yes	13C label:glucose | Hormone treatment:Yes	13C label:glucose | Hormone treatment:Yes	13C label:glucose | Hormone treatment:No	13C label:glucose | Hormone treatment:No	13C label:glucose | Hormone treatment:No	13C label:oleic acid | Hormone treatment:Yes	13C label:oleic acid | Hormone treatment:Yes	13C label:oleic acid | Hormone treatment:Yes	13C label:oleic acid | Hormone treatment:No	13C label:oleic acid | Hormone treatment:No	13C label:oleic acid | Hormone treatment:No	13C label:glucose | Hormone treatment:Yes	13C label:oleic acid | Hormone treatment:Yes	13C label:glucose | Hormone treatment:No	13C label:oleic acid | Hormone treatment:No	13C label:Pool | Hormone treatment:Pool	13C label:Pool | Hormone treatment:Pool	13C label:Pool | Hormone treatment:Pool	13C label:Pool | Hormone treatment:Pool	13C label:Pool | Hormone treatment:Pool
F6P m+0	1521745	2141800	2922134	4047110	1609930	167938	13520440	7031329	2849127	55359	2474115	494711	5255646	226271	58834	154564	741357	753366	736698	754159	715856
F6P m+1	11494	15785	15200	35570	5095	3048	0	24952	23492	1935	0	1387	16760	592	0	0	0	0	656	2995	2747
F6P m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
F6P m+3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
F6P m+4	0	0	0	0	0	0	0	445440	0	0	0	0	0	0	0	0	0	0	0	0	0
F6P m+5	0	0	0	0	0	0	0	51803	0	0	0	0	0	0	0	0	0	0	0	0	0
F6P m+6	0	0	0	0	0	0	0	0	11513	1498	0	1521	0	0	0	0	0	0	0	0	0
2PG / 3PG m+0	12613	91657	17262	201086	1019404	12739	5877533	45002	57295	365622	630920	2793251	62374	777542	70202	694003	1467832	1500656	1449476	1501381	1449268
2PG / 3PG m+1	0	0	1033	4178	22631	0	9363	1026	0	982	1926	0	974	0	970	0	2322	3656	3489	0	1062
2PG / 3PG m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2PG / 3PG m+3	164995	5053982	860013	1393740	4378473	52946	0	0	0	0	0	15876	13099	0	25302	25279	857053	836269	847096	824855	825308
sn-Glycero-3-phosphate m+0	1254253	562091	577913	1648729	2093699	2059016	14974180	9765169	11498470	9404976	11492030	21302530	9822959	9565388	7050959	16064630	8905099	9045230	9264182	9366112	9235544
sn-Glycero-3-phosphate m+1	22871	0	9159	15319	31978	21512	0	0	0	0	0	0	0	0	0	0	0	0	6358	0	0
sn-Glycero-3-phosphate m+2	0	0	0	0	0	0	14503	36957	35088	31242	25999	6405	40540	32158	46125	31488	0	0	0	0	0
sn-Glycero-3-phosphate m+3	22011240	9292293	7893119	7384057	7205429	10509690	7630	9196	0	0	0	0	0	0	0	2899	3989697	4052004	4244038	4316910	4218691
Citrate/isocitrate m+0	15441330	19509170	3783839	44174090	62318100	29544200	56948470	30747330	46123020	6900645	3632731	14249470	3839607	18281510	15975430	2975632	3271182	1887137	13480540	42305260	66965000
Citrate/isocitrate m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Citrate/isocitrate m+2	6569155	7826968	1670234	4802823	8311600	3311172	14013970	8595508	17811100	3216269	1155587	0	0	0	0	1546998	690536	372660	2545905	8385201	13681440
Citrate/isocitrate m+3	328645	397699	135353	1048444	1809495	835157	0	10617	53852	6642	0	0	0	1319	10071	16954	36026	31184	137792	358611	574739
Citrate/isocitrate m+4	292999	322998	116359	169109	369261	124914	417256	288522	1339712	281393	48726	0	0	0	0	186819	122162	16399	184601	528106	962080
Citrate/isocitrate m+5	285367	351011	117484	211177	385750	150005	8384	7088	68273	16082	1543	0	1356	0	0	15898	11323	11144	59055	169193	294004
Citrate/isocitrate m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Succinate m+0	16112750	12489780	11222880	15021310	16951830	12687990	15700260	14676020	17531760	13122240	11677400	16831110	14437760	15414970	14598960	2924546	16362320	16013940	15794180	15448970	15125620
Succinate m+1	0	0	0	26108	0	0	0	0	4126	0	0	0	0	0	0	13792	0	0	0	8152	0
Succinate m+2	1461903	992164	1088017	700434	1092880	628920	742255	689227	2204115	1990823	668965	0	0	0	0	587834	857442	834262	952747	938910	954791
Succinate m+3	62707	36272	52359	31415	53760	29032	27233	30896	158263	133024	36311	0	0	0	0	61098	73653	72264	61069	64793	56320
Succinate m+4	0	0	111995	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Malate m+0	77115420	59928090	68507530	69159670	65295190	74755380	79063730	83030380	82490740	80506500	65511310	71389490	80322170	76142330	81214900	82763210	73042610	71761110	72951480	74492710	72498900
Malate m+1	0	0	0	0	0	11570	0	0	0	0	0	0	0	0	0	8628	0	0	0	0	0
Malate m+2	2797176	2193747	3857871	1435119	1922267	1751323	1658485	1975704	4234636	5157918	2263129	0	21134	5201	1638	8385110	2344083	2365508	2236536	2244921	2171246
Malate m+3	2706985	2359571	3841036	3137332	3251270	3491960	30147	28616	161115	198952	49835	0	0	0	0	483935	1171537	1159008	1191495	1209281	1156968
Malate m+4	86778	74640	213950	42121	75057	58903	0	0	0	23	0	0	0	0	0	0	23229	28420	14370	24170	30943
R5P m+0	300053	57880	33846	295964	409505	475845	1799574	7260988	2604483	538546	7977745	828843	1019405	42448	1973902	797720	335974	344679	339787	379076	384962
R5P m+1	18128	920	1999	6349	9527	22896	11374	25748	12745	0	17142	0	9310	0	4017	622	5471	2622	2200	935	0
R5P m+2	0	40974	27028	92089	153297	34417	47992	0	0	56770	0	0	28747	0	22355	57903	0	68661	67234	62225	59976
R5P m+3	89905	40900	23080	109815	169909	76502	0	0	0	0	0	0	0	0	0	0	31057	20057	23150	22358	18197
R5P m+4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6204	2306	4489	2660	0
R5P m+5	1376557	1181122	915019	1555471	1518956	1190410	10363	7514	9974	11542	0	8278	9735	0	18236	13915	272697	263964	265019	264438	269807
6-phosphogluconate m+0	2473664	841342	1170964	1014704	587121	1867800	115448	182540	106890	98773	126188	113404	206690	140428	149003	143941	383983	415860	447171	368189	329976
6-phosphogluconate m+1	0	0	0	0	0	0	0	951	0	0	0	0	3892	3224	0	1247	0	0	0	0	0
6-phosphogluconate m+2	0	0	0	0	0	0	0	3374	2191	4312	2789	758	0	0	1212	0	8085	5407	4751	4355	3204
6-phosphogluconate m+3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6-phosphogluconate m+4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6-phosphogluconate m+5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6-phosphogluconate m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6729	2065	0	0
E4P m+0	7031	3336	5567	20585	33509	34166	129648	125936	302986	26130	100461	28000	0	0	0	0	6407	6099	6073	6813	6229
E4P m+1	0	0	0	7580	15005	19643	3754	0	4493	0	0	0	0	0	0	0	0	0	0	0	0
E4P m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
E4P m+3	0	0	0	0	15537	20023	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
E4P m+4	88744	20566	28403	65450	130834	181701	0	0	0	0	0	0	0	0	0	0	5529	0	0	0	0
S7P m+0	0	61710	44101	50243	148452	118848	2423979	2423522	7377307	662555	2424383	513148	211915	141482	559418	1307008	682556	726072	766778	780504	767600
S7P m+1	0	6663	9082	0	0	0	0	0	10426	371	3930	1125	1942	0	0	0	0	4034	5249	4457	2556
S7P m+2	148469	33850	23437	234910	493370	665471	34513	0	13201	0	0	0	0	0	0	40582	139399	155114	150098	158590	147018
S7P m+3	31589	0	18995	43058	99787	80471	0	0	0	0	0	0	0	0	0	0	27163	31747	28884	25773	28694
S7P m+4	87460	32511	23724	152237	336271	350420	0	0	0	0	0	0	0	0	0	0	44229	55025	59091	62274	62528
S7P m+5	264613	22764	15905	193649	586640	836841	0	0	0	0	0	0	0	0	0	0	150210	141642	147346	167146	176562
S7P m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
S7P m+7	3174402	433844	750226	1433505	2821860	4324418	0	0	1270	0	0	0	0	0	0	0	668892	716599	758474	779525	755791
Fructose 1,6-bisphosphate m+0	0	61710	44101	50243	148452	118848	2423979	2423522	7377307	662555	2424383	513148	211915	141482	559418	1307008	682556	726072	766778	780504	767600
Fructose 1,6-bisphosphate m+1	0	6663	9082	0	0	0	0	0	10426	371	3930	1125	1942	0	0	0	0	4034	5249	4457	2556
Fructose 1,6-bisphosphate m+2	148469	33850	23437	234910	493370	665471	34513	0	13201	0	0	0	0	0	0	40582	139399	155114	150098	158590	147018
Fructose 1,6-bisphosphate m+3	31589	0	18995	43058	99787	80471	0	0	0	0	0	0	0	0	0	0	27163	31747	28884	25773	28694
Fructose 1,6-bisphosphate m+4	87460	32511	23724	152237	336271	350420	0	0	0	0	0	0	0	0	0	0	44229	55025	59091	62274	62528
Fructose 1,6-bisphosphate m+5	264613	22764	15905	193649	586640	836841	0	0	0	0	0	0	0	0	0	0	150210	141642	147346	167146	176562
Fructose 1,6-bisphosphate m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+0	14591850	11704150	20559980	15940070	13761010	15317030	13641900	20300730	19854110	25193800	13509080	19339210	14641460	23940140	20969970	17265380	18104240	16946860	15350850	22234800	13562060
Glutathione - reduced m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+4	396375	919370	643450	427330	300905	333952	624059	328309	295532	653403	343406	684276	344097	742286	304773	465911	636841	607431	629941	778314	603645
Glutathione - reduced m+5	7428	53027	40761	22460	21284	10228	40056	15078	18091	43804	8951	43162	18740	37155	25530	30773	27926	30522	35061	35283	28619
Glutathione - reduced m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - reduced m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+0	42164180	40209160	40897420	37999070	37273560	40058210	42796420	39062410	39137560	44156690	32928790	43598500	47073680	47868980	40556270	47752580	45047280	44762790	46168080	43371520	42931770
Glutathione - oxidized m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+6	5060	0	0	0	0	0	2346	1320	375	234	0	879	6965	6801	6183	4317	10093	5983	4972	0	578
Glutathione - oxidized m+7	0	1812	2504	1610	2506	1445	1447	2029	3338	0	1370	0	3192	2983	0	4432	3041	3190	0	0	0
Glutathione - oxidized m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+10	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+11	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+12	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+13	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+14	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+15	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+16	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+17	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+18	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+19	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutathione - oxidized m+20	0		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+0	161474	127981	129242	397304	344766	334815	185776	227987	390918	240364	218000	138645	147762	152906	251810	229615	118922	125049	154254	159322	160536
FAD m+1	1738	0	5013	0	691	0	5536	0	2816	8155	0	0	6120	4031	4456	2582	7317	1995	1267	0	4608
FAD m+2	2666	0	0	1144	282	0	1036	3304	2522	607	0	0	2324	3849	0	3288	2326	2702	0	0	5227
FAD m+3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+11	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+12	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+13	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+14	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+15	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+16	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+17	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+18	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+19	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+20	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+21	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+22	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+23	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+24	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+25	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+26	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
FAD m+27	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+0	62330	48226	51775	67005	62093	68690	69752			141889		74760		147250	27885	134757	72373	74762	92474	104435	103422
Acetyl CoA m+1	1257	1987	254	0	317	784	0			0		1758		3129	352	1393	1228	0	0	1419	825
Acetyl CoA m+2	6035	7411	5926	3228	3414	3239	7504			24274		0		0	1159	24685	5179	7382	8737	7720	8023
Acetyl CoA m+3	109	0	418	323	0	0	0			0		366		374	0	896	127	138	10	0	998
Acetyl CoA m+4	0	513	0	0	0	75	472			154		0		340	0	0	0	193	0	0	0
Acetyl CoA m+5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+11	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+12	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+13	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+14	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+15	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+16	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+17	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+18	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+19	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+20	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+21	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+22	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Acetyl CoA m+23	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+0	7273498	5814256	7291118	9216491	9313125	9930571	8328055	8191549	11302410	11000020	6020025	8483804	8736616	11128940	11305910	11976970	9499779	9394594	9578655	9428866	9328428
NAD m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+3	2940	2167	10178	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+4	162	2046	0	3390	1587	2195	0	0	0	0	0	0	0	0	0	0	0	0	571	0	0
NAD m+5	45876	44397	90616	20996	40258	24410	0	0	0	0	0	0	0	0	0	0	11015	12187	16273	13684	12134
NAD m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+11	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+12	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+13	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+14	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+15	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+16	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+17	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+18	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+19	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+20	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NAD m+21	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+0	235725	168427	215845	369953	372077	412876	220123	236446	487480	430272	192907	232502	230491	395942	426606	444626	309102	299400	314745	328744	325587
NADP m+1	2804	155	3319	112	1249	0	1213	1365	1435	0	3048	0	1102	2265	3012	6813	0	2730	3187	0	5536
NADP m+2	0	2491	0	2408	0	0	2108	0	0	86	0	50	0	0	610	0	0	334	0	0	586
NADP m+3	0	0	741	738	256	492	0	0	0	0	0	0	0	0	0	0	0	0	275	1361	0
NADP m+4	0	0	107	1237	4052	838	947	0	0	201	1918	2919	0	583	1017	1720	1046	0	1338	597	270
NADP m+5	0	0	1230	0	0	855	27	462	1309	390	724	0	1284	310	711	0	248	1128	728	270	111
NADP m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+11	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+12	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+13	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+14	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+15	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+16	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+17	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+18	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+19	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+20	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
NADP m+21	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+0	7273498	5814256	7291118	9216491	9313125	9930571	8328055	8191549	11302410	11000020	6020025	8483804	8736616	11128940	11305910	11976970	9499779	9394594	9578655	9428866	9328428
AMP m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+3	2940	2167	10178	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+4	162	2046	0	3390	1587	2195	0	0	0	0	0	0	0	0	0	0	0	0	571	0	0
AMP m+5	45876	44397	90616	20996	40258	24410	0	0	0	0	0	0	0	0	0	0	11015	12187	16273	13684	12134
AMP m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+0	7273498	5814256	7291118	9216491	9313125	9930571	8328055	8191549	11302410	11000020	6020025	8483804	8736616	11128940	11305910	11976970	9499779	9394594	9578655	9428866	9328428
ADP m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+3	2940	2167	10178	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+4	162	2046	0	3390	1587	2195	0	0	0	0	0	0	0	0	0	0	0	0	571	0	0
ADP m+5	45876	44397	90616	20996	40258	24410	0	0	0	0	0	0	0	0	0	0	11015	12187	16273	13684	12134
ADP m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+0	31152790	18236850	31377440	22694280	22630630	29435820	32158420	40747370	45213820	43228870	32103630	32968120	42672420	48632090	51593480	46164720	31101360	31951250	34813130	34827980	33814080
ATP m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+2	22606	2982	0	27875	22954	42583	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+3	32857	24232	21689	26266	19585	38269	0	0	0	0	0	0	0	0	0	0	0	3226	5259	8323	6294
ATP m+4	0	0	0	6636	2402	9517	0	0	0	3628	705	986	1632	3898	0	0	3225	6620	0	0	3351
ATP m+5	673030	342253	611950	136120	179936	265181	0	143	0	0	5570	888	1082	307	1756	0	112119	117552	129998	134342	120308
ATP m+6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP m+10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Aspartate m+0	12870250	14503490	13261190	14354800	14442230	12750760	14575410	14709060	12215000	11244720	15480550	16858860	14503670	13923270	14089360	1821883	13831980	13787160	13470560	13637080	13267230
Aspartate m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Aspartate m+2	1146068	1312909	1526097	693689	899149	725522	780269	919403	1799212	1886254	1246193	0	0	0	0	409602	990231	1017524	968884	1010272	946862
Aspartate m+3	27727	43489	82980	44153	73599	40263	7800	6160	41222	42164	12458	0	0	0	0	19396	28016	34238	30946	29298	22658
Aspartate m+4	29150	30888	80350	20721	32428	20355	1522	9777	37529	58511	15908	0	0	0	0	18849	28825	28443	20964	28058	24157
Glutamic acid m+0	12870250	14503490	13261190	14354800	14442230	12750760	14575410	14709060	12215000	11244720	15480550	16858860	14503670	13923270	14089360	1821883	13831980	13787160	13470560	13637080	13267230
Glutamic acid m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Glutamic acid m+2	1146068	1312909	1526097	693689	899149	725522	780269	919403	1799212	1886254	1246193	0	0	0	0	409602	990231	1017524	968884	1010272	946862
Glutamic acid m+3	27727	43489	82980	44153	73599	40263	7800	6160	41222	42164	12458	0	0	0	0	19396	28016	34238	30946	29298	22658
Glutamic acid m+4	29150	30888	80350	20721	32428	20355	1522	9777	37529	58511	15908	0	0	0	0	18849	28825	28443	20964	28058	24157
Glutamic acid m+5	6466	13097	24612	648	9985	2096	0	0	0	483	1103	0	0	0	0	151	4898	3476	3100	3193	3735
Lactate m+0	12870250	14503490	13261190	14354800	14442230	12750760	14575410	14709060	12215000	11244720	15480550	16858860	14503670	13923270	14089360	1821883	13831980	13787160	13470560	13637080	13267230
Lactate m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Lactate m+2	1146068	1312909	1526097	693689	899149	725522	780269	919403	1799212	1886254	1246193	0	0	0	0	409602	990231	1017524	968884	1010272	946862
Lactate m+3	27727	43489	82980	44153	73599	40263	7800	6160	41222	42164	12458	0	0	0	0	19396	28016	34238	30946	29298	22658
Pyruvate m+0	27777	16073	16478	26255	36390	25093	211556	380466	365365	146341	320964	263286	214509	186878	278017	150116	71899	73814	83503	89699	95410
Pyruvate m+1	0	0	0	368	0	672	664	1190	165	0	0	0	0	0	0	570	0	0	325	543	253
Pyruvate m+2	0	0	0	0	0	0	2149	4404	4462	0	3998	2268	3285	2318	3455	0	0	0	0	0	0
Pyruvate m+3	732362	201601	546174	318318	298277	294368	266	0	0	87	0	0	0	0	273	0	115193	120310	134850	143265	141521
Oxoglutaric acid m+0	209372	301517	339150	269168	408076	113602	459580	186646	95506	149590	244912	855224	213996	426010	166985	179943	261004	270460	270387	275463	276396
Oxoglutaric acid m+1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Oxoglutaric acid m+2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Oxoglutaric acid m+3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Oxoglutaric acid m+4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Oxoglutaric acid m+5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name
F6P m+0
F6P m+1
F6P m+2
F6P m+3
F6P m+4
F6P m+5
F6P m+6
2PG / 3PG m+0
2PG / 3PG m+1
2PG / 3PG m+2
2PG / 3PG m+3
sn-Glycero-3-phosphate m+0
sn-Glycero-3-phosphate m+1
sn-Glycero-3-phosphate m+2
sn-Glycero-3-phosphate m+3
Citrate/isocitrate m+0
Citrate/isocitrate m+1
Citrate/isocitrate m+2
Citrate/isocitrate m+3
Citrate/isocitrate m+4
Citrate/isocitrate m+5
Citrate/isocitrate m+6
Succinate m+0
Succinate m+1
Succinate m+2
Succinate m+3
Succinate m+4
Malate m+0
Malate m+1
Malate m+2
Malate m+3
Malate m+4
R5P m+0
R5P m+1
R5P m+2
R5P m+3
R5P m+4
R5P m+5
6-phosphogluconate m+0
6-phosphogluconate m+1
6-phosphogluconate m+2
6-phosphogluconate m+3
6-phosphogluconate m+4
6-phosphogluconate m+5
6-phosphogluconate m+6
E4P m+0
E4P m+1
E4P m+2
E4P m+3
E4P m+4
S7P m+0
S7P m+1
S7P m+2
S7P m+3
S7P m+4
S7P m+5
S7P m+6
S7P m+7
Fructose 1,6-bisphosphate m+0
Fructose 1,6-bisphosphate m+1
Fructose 1,6-bisphosphate m+2
Fructose 1,6-bisphosphate m+3
Fructose 1,6-bisphosphate m+4
Fructose 1,6-bisphosphate m+5
Fructose 1,6-bisphosphate m+6
Glutathione - reduced m+0
Glutathione - reduced m+1
Glutathione - reduced m+2
Glutathione - reduced m+3
Glutathione - reduced m+4
Glutathione - reduced m+5
Glutathione - reduced m+6
Glutathione - reduced m+7
Glutathione - reduced m+8
Glutathione - reduced m+9
Glutathione - reduced m+10
Glutathione - oxidized m+0
Glutathione - oxidized m+1
Glutathione - oxidized m+2
Glutathione - oxidized m+3
Glutathione - oxidized m+4
Glutathione - oxidized m+5
Glutathione - oxidized m+6
Glutathione - oxidized m+7
Glutathione - oxidized m+8
Glutathione - oxidized m+9
Glutathione - oxidized m+10
Glutathione - oxidized m+11
Glutathione - oxidized m+12
Glutathione - oxidized m+13
Glutathione - oxidized m+14
Glutathione - oxidized m+15
Glutathione - oxidized m+16
Glutathione - oxidized m+17
Glutathione - oxidized m+18
Glutathione - oxidized m+19
Glutathione - oxidized m+20
FAD m+0
FAD m+1
FAD m+2
FAD m+3
FAD m+4
FAD m+5
FAD m+6
FAD m+7
FAD m+8
FAD m+9
FAD m+10
FAD m+11
FAD m+12
FAD m+13
FAD m+14
FAD m+15
FAD m+16
FAD m+17
FAD m+18
FAD m+19
FAD m+20
FAD m+21
FAD m+22
FAD m+23
FAD m+24
FAD m+25
FAD m+26
FAD m+27
Acetyl CoA m+0
Acetyl CoA m+1
Acetyl CoA m+2
Acetyl CoA m+3
Acetyl CoA m+4
Acetyl CoA m+5
Acetyl CoA m+6
Acetyl CoA m+7
Acetyl CoA m+8
Acetyl CoA m+9
Acetyl CoA m+10
Acetyl CoA m+11
Acetyl CoA m+12
Acetyl CoA m+13
Acetyl CoA m+14
Acetyl CoA m+15
Acetyl CoA m+16
Acetyl CoA m+17
Acetyl CoA m+18
Acetyl CoA m+19
Acetyl CoA m+20
Acetyl CoA m+21
Acetyl CoA m+22
Acetyl CoA m+23
NAD m+0
NAD m+1
NAD m+2
NAD m+3
NAD m+4
NAD m+5
NAD m+6
NAD m+7
NAD m+8
NAD m+9
NAD m+10
NAD m+11
NAD m+12
NAD m+13
NAD m+14
NAD m+15
NAD m+16
NAD m+17
NAD m+18
NAD m+19
NAD m+20
NAD m+21
NADP m+0
NADP m+1
NADP m+2
NADP m+3
NADP m+4
NADP m+5
NADP m+6
NADP m+7
NADP m+8
NADP m+9
NADP m+10
NADP m+11
NADP m+12
NADP m+13
NADP m+14
NADP m+15
NADP m+16
NADP m+17
NADP m+18
NADP m+19
NADP m+20
NADP m+21
AMP m+0
AMP m+1
AMP m+2
AMP m+3
AMP m+4
AMP m+5
AMP m+6
AMP m+7
AMP m+8
AMP m+9
AMP m+10
ADP m+0
ADP m+1
ADP m+2
ADP m+3
ADP m+4
ADP m+5
ADP m+6
ADP m+7
ADP m+8
ADP m+9
ADP m+10
ATP m+0
ATP m+1
ATP m+2
ATP m+3
ATP m+4
ATP m+5
ATP m+6
ATP m+7
ATP m+8
ATP m+9
ATP m+10
Aspartate m+0
Aspartate m+1
Aspartate m+2
Aspartate m+3
Aspartate m+4
Glutamic acid m+0
Glutamic acid m+1
Glutamic acid m+2
Glutamic acid m+3
Glutamic acid m+4
Glutamic acid m+5
Lactate m+0
Lactate m+1
Lactate m+2
Lactate m+3
Pyruvate m+0
Pyruvate m+1
Pyruvate m+2
Pyruvate m+3
Oxoglutaric acid m+0
Oxoglutaric acid m+1
Oxoglutaric acid m+2
Oxoglutaric acid m+3
Oxoglutaric acid m+4
Oxoglutaric acid m+5
METABOLITES_END
#END