#METABOLOMICS WORKBENCH swagatpradhan7_20240221_111637 DATATRACK_ID:4667 STUDY_ID:ST003145 ANALYSIS_ID:AN005161 PROJECT_ID:PR001956 VERSION 1 CREATED_ON March 28, 2024, 8:16 am #PROJECT PR:PROJECT_TITLE Muscle-type specific stress responses explain external ophthalmoplegia in PR:PROJECT_TITLE mitochondrial disease PR:PROJECT_SUMMARY Mitochondrial dysfunctions elicit progressive tissue-specific stress responses PR:PROJECT_SUMMARY that can be protective or deleterious. Here, we show that even different muscles PR:PROJECT_SUMMARY of an individual react differently to mitochondrial disease. In mitochondrial PR:PROJECT_SUMMARY myopathy (MM), the extraocular muscles (EOMs) are affected first, followed by PR:PROJECT_SUMMARY exercise intolerance in the large lower limb muscles. Both muscle types show PR:PROJECT_SUMMARY clear signs of respiratory chain deficiency. However, the limbs upregulate the PR:PROJECT_SUMMARY mitochondrial integrated stress response (ISRmt) that drives glucose carbons to PR:PROJECT_SUMMARY anabolic repair pathways, while EOMs present no signs of ISRmt. In contrast, in PR:PROJECT_SUMMARY EOMs, Pdk4 activation inhibits pyruvate metabolism, while beta-oxidation of PR:PROJECT_SUMMARY fatty acids is induced - despite the reliance of beta-oxidation on a functional PR:PROJECT_SUMMARY respiratory chain for ATP production. The data suggest that the inability to PR:PROJECT_SUMMARY upregulate ISRmt and consequent deleterious fuel choices sensitize EOMs to early PR:PROJECT_SUMMARY weakness and atrophy, explaining ophthalmoplegia, the most common MM sign. The PR:PROJECT_SUMMARY distinct responses to disease even in muscles of a single individual predict PR:PROJECT_SUMMARY different responses to treatment, which is essential knowledge when designing PR:PROJECT_SUMMARY interventions. PR:INSTITUTE University of Helsinki PR:LABORATORY Anu Wartiovaara Lab PR:LAST_NAME Pradhan PR:FIRST_NAME Swagat PR:ADDRESS C519b, Biomedicum 1, Haartmaninkatu 8, Helsinki, Uusimaa, 00290, Finland PR:EMAIL swagat.pradhan@helsinki.fi PR:PHONE +358465287359 #STUDY ST:STUDY_TITLE Muscle-type specific stress responses explain the onset of external ST:STUDY_TITLE ophthalmoplegia in mitochondrial disease ST:STUDY_SUMMARY Mitochondrial dysfunctions elicit progressive tissue-specific stress responses ST:STUDY_SUMMARY that can be protective or deleterious. Here, we show that even different muscles ST:STUDY_SUMMARY of an individual react differently to mitochondrial disease. In mitochondrial ST:STUDY_SUMMARY myopathy (MM), the extraocular muscles (EOMs) are affected first, followed by ST:STUDY_SUMMARY exercise intolerance in the large lower limb muscles. Both muscle types show ST:STUDY_SUMMARY clear signs of respiratory chain deficiency. However, the limbs upregulate the ST:STUDY_SUMMARY mitochondrial integrated stress response (ISRmt) that drives glucose carbons to ST:STUDY_SUMMARY anabolic repair pathways, while EOMs present no signs of ISRmt. In contrast, in ST:STUDY_SUMMARY EOMs, Pdk4 activation inhibits pyruvate metabolism, while beta-oxidation of ST:STUDY_SUMMARY fatty acids is induced - despite the reliance of beta-oxidation on a functional ST:STUDY_SUMMARY respiratory chain for ATP production. The data suggest that the inability to ST:STUDY_SUMMARY upregulate ISRmt and consequent deleterious fuel choices sensitize EOMs to early ST:STUDY_SUMMARY weakness and atrophy, explaining ophthalmoplegia, the most common MM sign. The ST:STUDY_SUMMARY distinct responses to disease even in muscles of a single individual predict ST:STUDY_SUMMARY different responses to treatment, which is essential knowledge when designing ST:STUDY_SUMMARY interventions. ST:INSTITUTE University of Helsinki ST:DEPARTMENT Faculty of Medicine ST:LABORATORY Anu Wartiovaara Lab ST:LAST_NAME Pradhan ST:FIRST_NAME Swagat ST:ADDRESS C519b, Biomedicum 1, Haartmaninkatu 8, Helsinki ST:EMAIL swagat.pradhan@helsinki.fi ST:PHONE +358465287359 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - WT_1_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_1_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_2_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_2_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_3_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_3_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_4_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_4_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_5_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_5_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_6_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_6_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_7_EOM Sample source:Extra-ocular muscle | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_7_EOM.mzML SUBJECT_SAMPLE_FACTORS - Del_1_EOM Sample source:Extra-ocular muscle | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_1_EOM.mzML SUBJECT_SAMPLE_FACTORS - Del_2_EOM Sample source:Extra-ocular muscle | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_2_EOM.mzML SUBJECT_SAMPLE_FACTORS - Del_3_EOM Sample source:Extra-ocular muscle | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_3_EOM.mzML SUBJECT_SAMPLE_FACTORS - Del_4_EOM Sample source:Extra-ocular muscle | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_4_EOM.mzML SUBJECT_SAMPLE_FACTORS - Del_5_EOM Sample source:Extra-ocular muscle | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_5_EOM.mzML SUBJECT_SAMPLE_FACTORS - Del_6_EOM Sample source:Extra-ocular muscle | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_6_EOM.mzML SUBJECT_SAMPLE_FACTORS - WT_1_QF Sample source:Quadriceps femoris | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_1_QF.mzML SUBJECT_SAMPLE_FACTORS - WT_2_QF Sample source:Quadriceps femoris | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_2_QF.mzML SUBJECT_SAMPLE_FACTORS - WT_3_QF Sample source:Quadriceps femoris | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_3_QF.mzML SUBJECT_SAMPLE_FACTORS - WT_4_QF Sample source:Quadriceps femoris | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_4_QF.mzML SUBJECT_SAMPLE_FACTORS - WT_5_QF Sample source:Quadriceps femoris | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_5_QF.mzML SUBJECT_SAMPLE_FACTORS - WT_6_QF Sample source:Quadriceps femoris | Genotype:Wild type RAW_FILE_NAME(Raw file name)=WT_6_QF.mzML SUBJECT_SAMPLE_FACTORS - Del_1_QF Sample source:Quadriceps femoris | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_1_QF.mzML SUBJECT_SAMPLE_FACTORS - Del_2_QF Sample source:Quadriceps femoris | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_2_QF.mzML SUBJECT_SAMPLE_FACTORS - Del_3_QF Sample source:Quadriceps femoris | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_3_QF.mzML SUBJECT_SAMPLE_FACTORS - Del_4_QF Sample source:Quadriceps femoris | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_4_QF.mzML SUBJECT_SAMPLE_FACTORS - Del_5_QF Sample source:Quadriceps femoris | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_5_QF.mzML SUBJECT_SAMPLE_FACTORS - Del_6_QF Sample source:Quadriceps femoris | Genotype:Deletor RAW_FILE_NAME(Raw file name)=Del_6_QF.mzML #COLLECTION CO:COLLECTION_SUMMARY Muscles were extracted by excision and snap frozen in liquid nitrogen CO:SAMPLE_TYPE Muscle #TREATMENT TR:TREATMENT_SUMMARY The experimental mouse model used in this study (Deletor) are transgenic for TR:TREATMENT_SUMMARY Twnk, encoding Twinkle, a nuclear-encoded mtDNA helicase that carries a dominant TR:TREATMENT_SUMMARY mutation (homologous to a MM patient mutation, leading into a 13-amino acid TR:TREATMENT_SUMMARY duplication of amino acids p.353-365 in the protein). The controls were TR:TREATMENT_SUMMARY wild-type (WT) littermates of Deletor mice. WT mice are used as controls. The TR:TREATMENT_SUMMARY genotype and tissue specific differences were studied by analysing metabolites TR:TREATMENT_SUMMARY from Quadriceps femoris(QF) and extra-ocular muscles(EOM). #SAMPLEPREP SP:SAMPLEPREP_SUMMARY The samples were added to 2 ml Precellys homogenization tube (Bertin SP:SAMPLEPREP_SUMMARY Technologies, Montigny-le-Bretonneux, France) with 2.8 mm ceramic (zirconium SP:SAMPLEPREP_SUMMARY oxide) beads with 500µl of cold extraction solvent SP:SAMPLEPREP_SUMMARY (Acetonitrile:Methanol:Milli-Q Water; 40:40:20). Subsequently, samples were SP:SAMPLEPREP_SUMMARY homogenized using a tissue homogenizer (Bertin Technologies, France) for 3 SP:SAMPLEPREP_SUMMARY cycles (30sec at 5500rpm with 60sec pause at 4°C). It was then followed by SP:SAMPLEPREP_SUMMARY centrifugation at 14000rpm at 4°C for 5 minutes. The supernatant was then SP:SAMPLEPREP_SUMMARY loaded into a Phenomenex, Phree Phospholipid removal 96 well plate 30mg (Part SP:SAMPLEPREP_SUMMARY No. 8E-S133-TGB) and passed through using a robotic vacuum. The resulting SP:SAMPLEPREP_SUMMARY filtrate was then transferred into polypropylene tubes and placed into a SP:SAMPLEPREP_SUMMARY Nitrogen gas evaporator to completely dry the solvent. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME Merck SeQuant ZIC-pHILIC (100 x 2.1mm,5um) CH:SOLVENT_A 100% water, 20mM Ammonium hydrogen carbonate, pH 9.4 CH:SOLVENT_B 100% acetonitrile CH:FLOW_GRADIENT gradient elution began with 20% mobile phase A and 80% mobile phase B and was CH:FLOW_GRADIENT maintained until 2 minutes. Then, mobile phase A was gradually increased from CH:FLOW_GRADIENT 20% to 80% until 17 minutes, followed by a decrease from 80% to 20% in mobile CH:FLOW_GRADIENT phase A from 17.1 minutes and maintained up to 24 minutes. CH:FLOW_RATE 0.100 mL/minute CH:COLUMN_TEMPERATURE 40 ± 3 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE UNSPECIFIED MS:MS_COMMENTS Mass spectrometry (MS) was used with a heated electrospray ionization (H-ESI) MS:MS_COMMENTS source using polarity switching and the following settings: resolution of MS:MS_COMMENTS 70,000, spray voltages of 4250 V for positive mode and 3250 V for negative mode, MS:MS_COMMENTS sheath gas flow rate of 25 arbitrary units (AU), auxiliary gas flow rate of 15 MS:MS_COMMENTS AU, sweep gas flow rate of 0, capillary temperature of 275°C, and S-lens RF MS:MS_COMMENTS level of 50.0. The instrument was controlled with the Xcalibur 4.1.31.9 software MS:MS_COMMENTS (Thermo Fischer Scientific, Waltham, MA, USA). In data processing, peak MS:MS_COMMENTS integration was performed using TraceFinder 5.1 software (Thermo Fischer MS:MS_COMMENTS Scientific), and the confirmed retention times of 462 metabolites in an in-house MS:MS_COMMENTS library developed using the library kit MSMLS-1EA (Merck) were used. The peak MS:MS_COMMENTS area data were exported as an excel file for further analysis. Data quality was MS:MS_COMMENTS monitored throughout the run using a pooled sample as Quality Control (QC), MS:MS_COMMENTS which was prepared by pooling 5µL from each suspended sample and interspersed MS:MS_COMMENTS throughout the run as every 10th sample. After integration of QC data with MS:MS_COMMENTS TraceFinder 5.1, detected metabolites were checked for peak, and % RSD were MS:MS_COMMENTS calculated. An acceptance limit was set at ≤20%. Blank samples for carryover MS:MS_COMMENTS were injected after every fifth randomized sample to monitor the metabolites' MS:MS_COMMENTS carryover effect and were calculated against the mean QC area. The acceptance MS:MS_COMMENTS limit was set at ≤20% for each metabolite. Background % noise was calculated MS:MS_COMMENTS with respect to the first blank against the mean QC area, and the acceptance MS:MS_COMMENTS limit was set at ≤20% for each metabolite. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak intensity MS_METABOLITE_DATA_START Samples WT_1_EOM WT_2_EOM WT_3_EOM WT_4_EOM WT_5_EOM WT_6_EOM WT_7_EOM Del_1_EOM Del_2_EOM Del_3_EOM Del_4_EOM Del_5_EOM Del_6_EOM WT_1_QF WT_2_QF WT_3_QF WT_4_QF WT_5_QF WT_6_QF Del_1_QF Del_2_QF Del_3_QF Del_4_QF Del_5_QF Del_6_QF Factors Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Wild type Sample source:Extra-ocular muscle | Genotype:Deletor Sample source:Extra-ocular muscle | Genotype:Deletor Sample source:Extra-ocular muscle | Genotype:Deletor Sample source:Extra-ocular muscle | Genotype:Deletor Sample source:Extra-ocular muscle | Genotype:Deletor Sample source:Extra-ocular muscle | Genotype:Deletor Sample source:Quadriceps femoris | Genotype:Wild type Sample source:Quadriceps femoris | Genotype:Wild type Sample source:Quadriceps femoris | Genotype:Wild type Sample source:Quadriceps femoris | Genotype:Wild type Sample source:Quadriceps femoris | Genotype:Wild type Sample source:Quadriceps femoris | Genotype:Wild type Sample source:Quadriceps femoris | Genotype:Deletor Sample source:Quadriceps femoris | Genotype:Deletor Sample source:Quadriceps femoris | Genotype:Deletor Sample source:Quadriceps femoris | Genotype:Deletor Sample source:Quadriceps femoris | Genotype:Deletor Sample source:Quadriceps femoris | Genotype:Deletor (S)-NICOTINE 0 0 0 0 0 0 0 0 0 0 0 0 0 1537278.786 1190101.21 2508290.362 1215460.543 899253.1827 1471926.448 1859370.873 2307439.632 2150161.697 2039623.597 1177821.492 1810526.369 1-AMINOCYCLOPROPANE-1-CARBOXYLATE 6959491.486 5427684.783 6323038.881 4890809.456 1500801.15 3493534.662 5946362.33 4609845.944 3867822.694 5107914.886 6224632.875 5810467.313 3911243.515 0 0 0 0 0 0 0 0 0 0 0 0 1-HYDROXY-2-NAPHTHOATE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11721873.38 2595734.552 23731127.95 0 0 0 0 0 0 0 0 1-METHYLADENOSINE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE 0 374513.7199 0 497747.0578 295756.3629 333593.5402 404400.1455 380459.6801 487011.6494 415614.3946 147049.1685 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE 0 0 0 0 0 0 0 0 0 0 0 0 0 3318293.976 2917689.644 3964055.293 3395838.812 0 0 6341570.669 4267605.448 4503410.807 4517007.732 5368869.362 2616940.776 2-DEOXY-D-GLUCOSE 0 0 0 0 0 0 0 0 0 0 0 0 0 20645775.28 21906012.81 22691373.02 18993460.8 19026012.93 18605224.29 21176696.58 20095679.75 16861032.81 22542564.67 13957470.42 18223138.05 2-HYDROXY-4-(METHYLTHIO)BUTYRIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 0 254647.183 0 0 0 0 314213.614 0 0 269915.7626 0 0 2-HYDROXYBUTYRIC ACID 75530658.63 87337739.87 52184940.7 43914905.01 135688734.8 81041065.33 46796072.15 56967180.33 210788570 41644236.15 41642161.7 60954223.61 50055757.96 50578150.06 67474944.33 51164822.84 131285363.9 41397166.29 95852235.77 87814144.91 70987616.46 54276846.68 70128605.01 36182478.38 71798849.45 2-METHYLGLUTARIC ACID 11416203.87 5832845.933 15043302.53 7529142.057 9038077.95 7502658.404 11629037.47 11991220.98 11111711.5 13373658.63 12053374.99 7167037.887 6845476.05 2287992.931 3162221.217 7707618.708 608294.433 4861425.097 1655756.609 5940283.242 7079266.18 2771036.954 4355477.365 1136583.307 6440813.182 2,6-DIHYDROXYPYRIDINE 940092.4016 971598.2334 0 1455430.999 0 821534.53 699373.7231 727202.2121 719606.691 0 532554.2617 1187397.987 1143809.617 0 0 0 0 0 0 0 0 0 0 0 0 3-(2-HYDROXYPHENYL)PROPANOATE 2294972.525 3752700.336 2335879.605 1426986.946 2902025.509 1749572.462 1489977.053 1491303.164 2491072.938 3129154.124 2303933.247 1367148.746 1904789.581 16924847.92 17635827.1 15705339.86 19649790.17 18406532.93 17498502.4 21536789.19 22049474.17 19690813.29 24228050.22 20274415.1 23310033.69 3-(4-HYDROXYPHENYL)LACTATE 48247918.35 68087304.16 38971367.17 26789735.75 37511557.38 51804126.63 27387041.93 36464461.89 16982050.77 48009995.25 31958428.06 51904093.36 27697121.03 44496288.78 58859425.82 69972413.24 99264902.68 20711672.68 23259184.44 77654347.33 46805799.08 43694368.01 56738393.89 15928285.66 47264388.68 3-HYDROXY-3-METHYLGLUTARATE 55169731.33 47053591.2 33408406.51 34951027.6 48150160.55 32817850.91 32342269.58 35282585.99 24947263.24 39939050.35 32949111.14 33251488.81 32425913.91 14714026.06 13939392.3 17716905.99 16590807.42 11596344.97 6463085.724 11609822.34 20890827.36 11402592.71 19563762.9 8397519.559 8824972.613 3-HYDROXYBUTANOIC ACID 19745439.88 28042418.44 18375401.79 14972238.47 24801775 14457179.47 17857592.11 17024838.04 25700574.74 21076813.13 16585540.64 15677915.17 15233877.55 24668144.56 29181294.67 26747694.64 33522444.58 15684196.79 15630612 35430378.2 31864794.78 19384359.92 44817865.31 23894956.06 25435438.94 3-METHYLADENINE 250524.8876 434765.1152 840142.318 1063642.89 1471874.78 0 960976.0066 143553.0232 154120.2435 73873.70518 107195.5858 1962109.905 4408543.811 0 0 0 0 0 0 0 0 0 0 0 0 3-METHYLHISTAMINE 1751593.907 1017893.27 284430.4744 1526032.485 802776.727 869238.7581 1037890.498 956540.0259 939669.7821 1149309.519 1459597.868 1142461.641 1113935.02 0 0 0 0 0 0 0 0 0 0 0 0 3-UREIDOPROPIONATE 35600193.05 46960403.1 6561042.355 19263074.43 7834126.192 12588336.58 10393276.53 24299969.09 6762499.21 25070336.75 16399947.98 22202168.96 22542189.87 6625465.291 8214076.424 7516753.61 16101648.38 5524562.205 1131207.037 9404608.287 4567790.909 8997768.792 14135334.82 2678063.759 7296520.98 4-GUANIDINOBUTANOATE 160926444.7 162963610.8 165625579.9 134501310.9 124272649.1 75924183.13 88119637.75 101191810.8 44114601.6 134558408.5 112532033.4 95399308.99 116016023.5 74921175.42 77676624.6 82844904.43 88237306.78 85478554.47 55229520.89 74177121.36 103034947.6 86079726.85 105766768.7 39052527.35 47149604.18 4-HYDROXYPROLINE 23024349.37 17942285.91 9104257.841 15548901.74 15970781.89 8506673.148 10987854.67 12358209.52 6563338.097 15679511.81 6118415.017 18030512.65 12286278.62 20798329.67 32329068.61 24158468.76 15254961.14 45884422.07 18641439.5 16405688.26 29059356.08 16466043.58 14223631.06 11214215.85 8289329.216 4-IMIDAZOLEACETIC ACID 15195166.67 17104374.53 0 10358333.12 5626983.316 4574102.028 4290135.228 11196253.87 4232413.543 10016506.66 5911187.864 6968373.773 6599682.188 7863862.584 5441238.227 5107480.122 6896751.718 5670631.334 4802474.984 5108868.598 10463055.7 4874505.284 9047067.794 4644764.822 4498980.419 4-METHYL-2-OXO-PENTANOIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 65200515.21 59987801.81 55375830.03 18927911.25 119476155.7 53665707.38 29044181.16 82788061.73 37498904.82 77862335.5 24875793.72 14062793.91 4-PYRIDOXATE 293848.3769 2476454.832 3433842.947 414525.7023 679175.1421 0 133204.8664 578386.0337 599648.5024 218404.2688 190873.5641 459490.6647 104150.8166 0 0 0 0 0 0 0 0 0 0 0 0 5'-METHYLTHIOADENOSINE 16005577.99 12619776.16 20207571.98 9681331.692 18624540.29 9496326.691 9385500.152 12350876.54 9574073.113 12766948.98 8818039.411 9194085.439 8534246.712 23592617.64 26142417.4 22765924.33 21257426.48 27538320.3 18600729.1 27874703.41 19726191.32 36807983.87 41494758.51 26417025.24 29160989.35 5-METHYLCYTOSINE HYDROCLORIDE 8309761.889 13234230.08 8730301.708 4544827.767 3548970.532 3428718.086 3831363.212 6502091.167 2808585.112 6221383.844 3950112.911 6454701.591 4267215.89 0 0 0 0 0 0 0 0 0 0 0 0 5-OXO-PROLINE 836120222.5 943672900.6 802758378.5 496409395 782114710.2 292945198.2 341276230.8 545180541.6 419823858.8 829309717.7 368954658 387783120.7 327850371.2 324287041.4 267178164.7 249501725.4 321076337 262138615.8 232185379.8 278048369.3 362762878.5 326213569.5 346381404.3 317840281 355093421.2 5-VALEROLACTONE 19650058.04 32550776.45 22516252.01 27321977.78 18755106.06 22389755.95 28666250.79 27600053.42 24030034.78 32734483.18 19671692.21 23876722.07 14646657.59 0 0 0 0 0 0 0 0 0 0 0 0 5,6-DIHYDROURACIL 2726483.724 4590649.222 2706351.03 1606544.192 3591820.943 1527492.717 664693.6015 0 104843.8953 930667.4044 1043950.497 2149863.747 1565465.831 0 0 0 0 0 0 0 0 0 0 0 0 Acetic Acid 78419537.95 140500188.1 273427245.2 115142803.9 73342694.32 79061610.22 74196225.52 90712872.38 81668055.57 83292410.68 71030518.85 96072296.49 92343942.38 49272161.02 153812009.6 45757472.86 57899275.57 174949310.9 258296622.2 128633487.8 109151289.5 269462059.4 203118119.3 203814170.9 188510420 Adenine 0 0 0 0 0 0 0 0 0 0 0 0 0 473980108.6 243208522.9 221007868.9 349034187.2 241735133.3 371603173.3 397541051.1 151881895.1 392234498.7 309612688.6 822224641.8 1147160549 Adenosine 5744120708 11208532569 2980784127 4725191952 6855465802 6918574898 9581189499 1842799917 8746061935 6932611798 6673158358 8408759164 6389267561 219365445.4 142520003.3 192349336.3 426645285.9 168628048 203543079.5 318770165.8 187509864.2 430652372.2 217306674.2 402526263.9 1066460234 ADENOSINE 5'-DIPHOSPHORIBOSE(ADPR) 28137714.83 107052436.4 87782622.55 99150811.1 133262434.1 106505997.4 122118068.3 121009631.9 87205190.7 158129427.8 148494336.4 106730031.9 100252801.2 0 0 0 0 0 0 0 0 0 0 0 0 Adenosine cyclic monophosphate(cAMP) 20147955.41 37915268.2 5060400.087 26966164.94 34909698.03 31282847.32 40449870.68 7214861.979 26334266.71 35871050.28 25469306.02 46957452.53 34114764.95 0 0 0 843430.0495 2020419.703 545265.2838 1250533.332 0 2018656.701 0 1085749.392 1791766.053 Adenosine diphosphate(ADP) 15917389.71 7986633.306 14441461.3 0 45833171.08 0 31009348.75 0 0 0 28259443.03 0 10474803.94 20423154.2 41423898.36 54207769.21 19749305.43 37505091.19 26829490.29 44278349.29 69011520.64 55351442.1 67590219.91 38406566.79 23604582.22 Adenosine monophosphate(AMP) 398008843.8 636384087.6 128619280.3 846265107 648154073 663115648.3 512174472.2 48227825.17 599246430.4 1117545947 543949797.3 498381831.4 472216687.6 9194594.039 7035161.357 8121077.591 9610865.487 8083461.379 10605433.21 17946508.21 8479636.934 9346457.033 8957973.877 10794747.07 38261635.6 Adenylosuccinic acid 7379902.918 2789086.381 3224319.963 959648.7803 804337.1439 1686130.454 3227405.595 1852728.736 735205.8446 2449135.459 5535564.349 3029542.255 1426022.682 3721015.679 1162478.943 6410931.738 8206030.985 690810.3099 2814812.507 8871762.387 3766568.319 3227344.236 3226235.051 7942560.151 24634008.53 ALLANTOIN 32383967.94 47791886.68 86489608.28 22479366.36 29259733.21 12199954.81 18485300.02 27447286.91 14668862.98 22147546.47 20901614.71 26765112.66 21956588.3 12712911.81 12148358.3 15258201.99 16920720.17 18484204.09 10915409.08 12210691.54 14578173.88 19080019.29 15148346.48 21430288.42 15231296.04 ALPHA-AMINOADIPATE 35929559.5 44837163.13 34843981.66 36931163.05 39279531.52 24546046.43 23486144.01 30711931.2 30825851.77 38396229.51 27047479.03 27166067.42 26123300.72 7772712.442 10176641 12193478.56 15570063.27 9952653.79 9474686.459 20400007.38 20560421.81 17703419.74 17156215.28 19435357.69 17241766.91 ALPHA-D-GLUCOSE 1-PHOSPHATE 194345025.1 307853952.9 87523853.95 74658643.01 28394002.89 61600446.48 59993156.69 135432040.4 29640047.88 201870358.7 310241393.7 333581488.6 211968844.2 0 0 0 0 0 0 0 0 0 0 0 0 ALPHA-KETOGLUTARIC ACID 14277095.72 9462709.377 6597691.406 8633325.852 14434526.07 9093546.263 9835462.569 11387839.95 16439369.7 6627670.819 5340980.98 14793290.99 8016372.017 9609498.478 9493807.647 11690943.87 8813209.761 15349147.86 15082502.58 13828930.56 18041173.99 13313723.27 12344497.52 7328404.45 16207847.83 AMINOISOBUTANOATE 0 0 0 0 0 0 0 0 0 0 0 0 0 34526403.57 42142647.7 106332788.7 63445208.58 38751198.25 38688693.16 46873834.57 50833044.89 75085281.13 50584953.74 41037803.72 48991111.4 ARACHIDIC ACID 673365511.1 37080710.47 71099601.27 29612417.59 651977095.6 56190617.85 636623113.8 137606914.6 432736125.5 47890086.58 613982888.4 43601468.78 139671867.1 0 0 0 0 0 0 0 0 0 0 0 0 Aspartic acid 339046545.6 313866392.3 521985237.6 221043989.5 334174369.8 372766021.4 286395770 144323662.6 218675637.7 407650525.7 312547911.6 185930279 325879787.1 211746191 218928692.9 180478146.8 198565583.6 183244006.2 198480224 199842553 277303022 182711222.6 244509110.2 266220750.2 230518075.5 BETAINE 12782143710 16398290885 9082879900 9619771056 11409278996 10398604700 9438861010 9864937106 5860719502 9864469125 8753320264 8244234305 7103979900 9889424473 10189915564 12655590012 10601019368 7677891518 8642628628 9439891466 13443147073 10726339424 14366304473 5925873401 7454584213 BIS(2-ETHYLHEXYL)PHTHALATE 24444179.24 38638242.32 31861043.36 37220015.73 15768821.44 30510445.58 18813707.13 30325788.48 22401898.42 28371393 22081758.68 27471630.12 31595657.41 6925572.147 5089180.169 21975943.54 5838867.498 7321300.475 4486581.682 9996296.697 5860973.295 13304487.17 4615145.485 4636476.48 8167536.366 BUTANAL 17989342.61 31584459.5 15029755.96 28962880.05 13713099.84 16899139.05 18194401.71 14869451.24 17496362.57 24817527.4 15787705.09 17746903.53 14499913.52 3636527.387 7966150.787 2897469.618 3352518.053 5867366.085 12316046.42 5195343.949 3401329.384 15764557.78 6844150.886 10630946.5 9513126.773 BUTANOATE 9976077.131 17107932.24 8265876.032 8786503.52 5568507.483 12672446.06 7365478.517 12458860.08 11475877.26 9129758.632 8565809.863 8278952.923 7144253.148 8744559.501 7419078.439 6945646.448 6848370.387 16292321.13 20445223.12 8170552.591 7638882.613 22198903.01 6329452.101 20194465.05 20817315.39 CAPRYLIC ACID 54467205.36 62802161.32 50462918.41 45657264.1 69536178.71 56455316.49 65311607.12 63873740.53 80042081.61 65221120.04 74292519.83 56900667.51 57679497.03 19168112.6 21652050.38 22909757.63 17321460.27 24503843.27 32831575.91 22309817.41 20926597.09 30106786.35 22470228.91 26564473.36 26640943.33 CARNOSINE 722142009.8 519512212.5 630683835.5 644488754.3 469947910.4 752996456.3 523251968.1 522528495.2 507309438.2 630887216.1 608686587 530738950.5 618983388.4 16218641070 15542157352 15371632222 5211342683 13368999132 17120338892 10026824739 16264464315 12769575921 14669052490 13593063439 6396284082 CHOLATE 501190.7703 1331285.501 1447596.517 5220018.571 4392555.934 14877909.69 1217851.281 3943184.247 538392.1885 2812597.524 468311.9964 6936516.265 2356775.097 209359.7098 0 267652.9928 1061811.256 0 9051534.97 0 230331.3821 1506297.825 1847390.781 0 635487.6713 cis-Aconitic acid 66211298.56 12940664.81 96463400.45 9470194.64 5906254.964 5868677.799 7301246.939 12525625.65 5769509.38 11519463.15 4637267.617 48731579.47 6365292.379 65976506.59 66840010.47 44850808.49 39460828.85 41451039.06 57099764.78 44523221.88 90518166.74 57704372.55 64843854.57 69025920.9 45534325.63 CITRAMALATE 248006376.2 292516719.6 275450918.3 242679838.6 317669068.6 192748776.2 212332147.8 178786105.1 137264380.2 223894274.6 189419502.6 205640259 214421657.9 154727260.6 161995043.8 219463681.8 400576707.5 115011079.5 108215017.7 264035129.4 195663350.1 158145990.9 168953622.5 101628588 230694632.7 CITRULLINE 1030285233 934759890.2 834166248.7 716609792.5 1093129169 658080369.4 778431152.4 793861560.4 487696187.9 938272446.2 652953221.5 729636381.7 910841977.7 1673610797 1656318156 1705615211 1592652885 1411353126 1321172077 1597762637 1818461147 1901189404 2128318390 1540601952 1526379812 CMP 15537873.64 20507418.77 13152582.89 6796843.207 11918779.29 5080600.445 6413367.198 7136472.735 5290354.404 11167957.64 13733873.62 11406246.92 8948448.785 2384226.459 2874724.213 2839864.363 2618521.567 2302282.445 1244706.31 2011619.55 3014346.961 2312118.273 2330454.523 2446846.517 1381889.145 COENZYME A 21152823.25 25143386.58 5669610.788 22216714.79 20333923.21 16154698.02 17668058.47 16792845.15 14717003.2 18146506.79 21107273.34 22971028.63 17973337.49 0 0 0 0 0 0 0 0 0 0 0 0 CORTISONE 0 0 0 0 0 0 0 0 0 0 0 0 0 1563039.655 1606938.053 2137178.363 1937877.703 971250.6742 1626897.11 2738214.4 1684149.374 1140916.002 1753498.111 1811219.486 2340839.345 CREATINE 1.36275E+11 1.36971E+11 1.25209E+11 1.36775E+11 1.29627E+11 1.28724E+11 1.26356E+11 1.25707E+11 1.19293E+11 1.43092E+11 1.35397E+11 1.36604E+11 1.23582E+11 99121208195 1.02616E+11 94276482298 1.02704E+11 1.02182E+11 1.01801E+11 1.05474E+11 91308162582 1.08102E+11 94899470941 99137552291 1.01915E+11 CREATINE PHOSPHATE 15041361.71 3825961.102 58284780.79 6174575.967 76314316.7 61499865.67 124296205.5 111189406.9 46629001.68 6026561.098 105907621.9 71501279.68 72061322.93 5630046.789 4015276.3 6257288.768 7074372.599 7565132.5 5825466.826 3218544.922 2474586.83 4495872.151 0 2701097.023 4404028.997 CREATININE 3490718683 3499290069 3429681967 2923041637 1633880384 2049399440 2825134793 2638687765 2159488730 3047798383 2912965781 3073107956 2623203121 6870551311 7258934613 6775002760 6267953874 5892036025 5167353290 5915280434 7112653780 6414909632 7188962452 5149408806 6550696123 CYTIDINE 283725806.7 363801597.4 196586908.3 192826711.1 197292155 123650631.2 136612719.7 260013424.2 158329531.1 206590322.8 172342938.4 196278478.4 165050282.4 177763901.8 210039774.9 146660541.1 131224155 444334021.5 112152973.6 147068322.6 191274926.2 245069866.6 190973622.9 166497472.9 174552730 CYTIDINE 5'-DIPHOSPHOCHOLINE 163509689.4 157846636.8 120376477.6 93778969.03 245443897.5 77908604.03 108233980.1 110179834.8 91530252.78 122688644.6 112428138 140493822.6 89897964.38 236926844.5 217298414.4 162262181.4 149411605.6 143690227.1 146569624.9 160908586.1 156836364.2 125826577.5 208956667.5 233847005.6 183180596.2 CYTOSINE 0 0 0 0 0 0 0 0 0 0 0 0 0 10534518.68 11504456.17 14713955.01 9386392.129 14361555.26 11096416.39 8193272.964 8077224.753 7285770.186 11883532.91 6516898.981 10566580.69 D-(+)-RAFFINOSE 80958837.04 56766190.58 33014785.93 17863161.65 9538685.392 4013794.073 4512634.375 73787022.2 6790565.238 29949047.67 50678717.53 23260086.35 17909540.1 0 0 0 0 0 0 0 0 0 0 0 0 D-FRUCTOSE 6-PHOSPHATE 194345025.1 307853952.9 87523853.95 74658643.01 28394002.89 61600446.48 59993156.69 135432040.4 29640047.88 201870358.7 310241393.7 333581488.6 211968844.2 0 0 0 0 0 0 0 0 0 0 0 0 D-GLUCOSAMINE 6-PHOSPHATE 1761009.4 972015.3444 673863.0449 128067.4927 0 0 0 212178.499 0 789976.0022 910649.4681 3671602.261 723270.669 916913.9429 1139522.949 758588.5539 1389302.375 841404.9112 657754.2619 1094590.345 1096918.247 767766.5561 1316748.152 866711.672 895334.5358 D-GLUCOSE-6-PHOSPHATE 267671854.7 304119434.5 98923094.63 96925198.1 8675448.233 59778034.93 55435565.14 67122692.86 28071340.29 224544723.4 227682064.1 616212406 207999323 5553412.319 6416114.938 7394865.2 21150799.19 4653453.562 5022695.377 7357923.516 8159453.132 8385874.761 7923112.115 4703348.143 6448417.087 D-GLUCURONIC ACID 2816493.738 787874.2869 0 867301.0456 2053312.271 394155.1173 911008.1434 1117583.197 726053.4205 0 181648.6246 603639.0631 1127322.543 0 0 0 0 0 0 0 0 0 0 0 0 D-MANNOSE 6-PHOSPHATE 72976644.45 49412799.22 26088345.08 16321461.72 348260.5187 9452817.427 9562292.524 11916956.78 4583051.339 36610728.16 40197744.47 152000554.9 37096561.53 5274701.776 6516014.134 6446779.279 12638364.76 5378319.705 4651286.866 6674942.947 7816227.276 7804240.383 7344059.873 5872520.072 6630225.271 D-PANTOTHENIC ACID 1883736250 2815453565 1865678427 1558418100 1749367782 1768905899 1761189918 1661053380 1239990449 2002732689 1660410538 1945467760 1619154516 730753059 843292836.9 1096791728 1599619875 1188662406 555765590.8 1053624756 1313195193 1761071439 1002615300 828716398.5 1198876261 D-RIBOSE 5-PHOSPHATE 0 0 0 0 0 0 0 0 0 0 0 0 0 197498459.2 198713017.7 185472090.6 222663016.4 175354980.7 186626909.7 245617172.2 211622801.9 210121588 208243721.4 184447603.2 280718993.3 DAMP 1957783.587 4606070.12 3020994.275 3246754.22 2945031.883 980060.5769 1269509.616 52703.66035 1739947.594 2780222.099 1801723.195 1714928.919 1979658.849 0 137528.7423 0 212008.4616 0 0 689170.4668 211897.691 1214669.803 534529.1656 0 631233.3017 DECANOATE 19466858.67 22727935.19 17376179.66 10903657.1 20662036.88 17293571.94 15866438.73 20126265.99 21928534.19 20899525.37 20521974.72 16742487.2 21247095.11 10208570.8 8648716.73 8590288.439 9470361.185 11450988.23 10936161.15 12515519.31 11349541.14 9599284.675 9740694.841 9468688.299 9104850.02 DEOXYCARNITINE 460807100.1 459177085.4 402607712.6 284166516.2 419796342.4 504683272.8 376052545.3 340923832.8 259718543.5 460992207.6 451193174.1 362244161 277141080.2 662027071.2 824139778.5 672425335.5 715271807 492089952.4 619290040.5 621376921.6 769939622.7 755512017.9 620704437.1 600014163.6 906151407.8 DEOXYCYTIDINE 0 0 0 0 0 0 0 0 0 0 0 0 0 9904945.152 10354964.23 13744754.27 9961974.311 17509123.35 10950071.73 7825241.512 7664667.117 9397683.242 11653957.76 8922436.651 14153246.06 DEOXYURIDINE 681683.0038 1816437.062 536227.484 340442.9748 548039.9717 330409.159 234180.3798 1418366.563 280888.087 386138.0347 0 1856388.705 113902.3921 0 0 0 0 0 0 0 0 0 0 0 0 DIACETYL 6687783.87 9575138.497 5752871.461 6768398.317 8490261.467 6803417.238 4834067.588 8831003.678 5410262.347 5755209.807 6283125.341 9708876.639 8368068.745 8578467.189 13664895.8 5203674.734 7689983.56 11949731.84 14170124.83 9575604.768 6015305.756 11341397.96 9579534.97 8783508.223 15934707.77 DIETHANOLAMINE 238541046.9 330423382.5 449080753.9 253351739.5 250859750.3 257119199.7 341485726.7 384641117.9 265961993.5 358708613.1 363615298.6 206533815.9 325513678.1 515845402.8 363062799.8 392643639.9 392706855.1 364698975.3 382166755.9 576876103.5 305478050.7 372537392.6 400543435.3 310949953.1 452624186.3 DIHYDROXYACETONE PHOSPHATE 82830682.75 131578196.2 85458768.8 53092550.52 37393504.17 59973440.58 50373487.01 180066285.8 49492324.43 127663908.8 144462683.1 103960840 72288990.73 0 0 0 0 0 0 0 0 0 0 0 0 DOCOSAHEXAENOIC ACID 95561156.26 60625433.03 83356259.77 62365975.44 88036182.57 41589139.57 37986907.04 82791270.68 38244763.4 48048836.31 42070558.76 49802058.98 38915129.06 0 3638624.34 498498.4573 6219513.901 0 0 2847760.736 667341.7578 287345.9167 549885.2699 2433528.659 789616.9185 ERUCIC ACID 9655291.86 3762495.92 0 6363435.299 0 11238197.86 0 10796035.89 8062555.784 13297888.52 5972580.716 14927456.04 10748583.25 0 0 0 0 0 0 0 0 0 0 0 0 ETHANOLAMINE PHOSPHATE 100961689.1 100581467.4 66524081.94 31484601.85 83057949.68 32644783.72 40992708.05 53643784.37 33664356.81 45931288.75 79499363.45 69231541.79 63802923.37 19519753.62 22025614.22 17674248.42 22657132.81 20513535.17 15443876.09 22192257.88 23415805.17 19376603.95 27779502.9 34683538.38 23570213.57 FLAVIN ADENINE DINUCLEOTIDE 8308016.589 5235139.729 2939368.086 6212837.579 5107458.29 2867170.51 5879833.476 3973073.973 5096438.852 7350540.809 4601012.497 4500372.462 2707032.312 2690710.373 2065970.116 1698542.552 3309477.809 3779272.36 2145417.435 4631117.077 2768678.161 7876314.056 2053360.582 700435.6678 4898149.083 FORMYL-L-METHIONYL PEPTIDE 4361952.971 3949045.001 3754965.918 2665182.047 3474565.8 2474204.023 2916463.699 2659361.151 2327131.91 2941036.899 2641919.7 3083764.51 2751816.643 4638486.497 4841703.97 4534966.074 3864992.679 2407065.311 3181338.156 3989092.028 5799736.219 3542703.768 3494708.094 2269796.672 4328113.756 Fumaric acid 190933225.6 210839565.8 259781452.4 117191554.8 149874702.7 147641878 118394898.7 190864103.5 112799342.3 162183572.9 170299665.5 148711161.3 170717478.9 126782940 125465633.8 177323836.1 297579349.9 44314537.86 114786637.3 223118068.2 204794963.2 139726415.3 150452674.8 178277913.7 258414325.8 GABA 1795703605 1303530942 1447364134 836648775.8 662979937 572024105.2 436131390.5 1349344164 520535935.9 620373303.6 729362593.9 1088530848 729608737.4 90061272.16 73718575.02 102604824.6 187355435.3 113866298.1 134401762.6 123349132.9 159681643.1 124492471.5 117218256 162976937.9 258595717.8 GALACTARATE 0 0 0 0 0 0 0 0 0 0 0 0 0 19236012.36 25986122.5 23080020.29 19684345.87 22864044.43 18890141.89 32526033.24 30636651.34 24120738.02 28369933.02 22615041.08 26850973.18 GALACTITOL 25703455.94 21397806.35 19802538.53 24627208.88 21523480.91 12700009.82 15520336.49 17725328.57 14888736.78 17405665.47 17662048.73 18195985.14 17565195.97 23909299.88 25608505.99 25161283.47 18947314.37 35334501.9 20232082.3 17617568.8 28296482.27 25405638.29 20604537.22 14848603.49 14708100.24 GAMMA-LINOLENIC ACID 47344604.57 47139956.61 69215813.91 41251047.29 36021120.93 14244301.31 10552409.69 100003091.5 25778808.83 31521495.15 18296791.28 10125992.94 13986536.81 0 0 565165.6429 4527524.576 0 0 828510.5024 0 1386132.383 583942.1624 0 0 GLUCONIC ACID 64421374.85 70238854.32 0 36971358.61 91297838.21 23602570.56 45937827.3 42195493.88 36026261.86 39745255.38 38034610.37 36740254.08 25992691.11 0 0 0 0 0 0 0 0 0 0 0 0 Glucose 14150351.47 15195462.77 19476823.26 17833882.85 18246251.63 14750066.31 15482062.77 19326141.28 10627660.74 19102834.78 19020869.53 21388184.87 16147337.3 0 0 0 0 0 0 0 0 0 0 0 0 GLUTARIC ACID 30291968.07 27058749.33 44726566.58 20798006.3 40545155.19 26882091.76 36801658.99 38834321.81 37561289.52 47155525.68 44109405.09 26787840.09 26867704.16 4192457.295 7423133.865 20103703.76 6308729.877 16111017.47 9571864.658 16034986.22 15652051.99 9621801.264 21482867.73 9731589.543 19593934.33 GLUTATHIONE 469509618.9 523022854.1 377177075.6 476972648 433656950.4 419264263.2 484601043.2 435104842.5 470446980.6 564008267 464869066.1 441689461.2 424566081.1 1108056486 1239793350 1189238024 1205222929 1402739643 1099924000 1199389184 1546485674 1421580605 1229243951 928282306.9 1004228182 GLYCERATE 21780062.99 16109725.1 0 18840281.02 14242600.19 7836318.787 9586904.051 11864475.39 6954138.91 13254636.2 11786773.37 11861313.04 10508779.27 20393211.07 22458390.91 17829282.11 15916479.88 11810571.95 11822774.46 14252831.76 22647238.98 15115589.5 22027290.32 6129805.417 9026343.298 Glycerol 2-Phosphate 21626082.2 16303311.32 12676015.42 17729975.9 25585192.9 17303212.9 19008205.8 17148237.5 17294089.72 20808356.07 18387567.86 23250243.03 14117970.91 5470302.5 6743716.872 5872586.086 6341847.968 6058361.567 4794482.671 6366710.645 7783162.134 9202044.996 9315801.768 7885408.838 5859209.85 Glycerol 3-Phosphate 0 0 0 0 0 0 0 0 0 0 0 0 0 21436848.8 29993848.57 144348947.2 366272001 11010787.02 34171680.86 97085769.1 35104408.09 50678894.72 33644019.07 17341802.8 156421467.2 Glycine 188753098.8 204925424.5 200137436.7 152457878.6 263711046.4 139976509.1 224891182.3 153353646.6 144646864.2 222516706.1 226377084.3 156975600.8 167195907.2 382362879.7 309658109.7 295961218.6 199544659.3 387360957.4 352870129.9 287805090.8 412789562.2 348060419.6 483169971.9 428983232.2 275392684.2 GLYCOLATE 6021199138 7430992679 6147852001 5605069303 8608347804 7053371591 6341682911 7563283789 5474758613 5701122791 8115989121 7928700335 6968208076 8717290401 8744038532 8718214213 8538575664 7454205167 7297628573 8404710862 8608192467 7089214959 8288794810 7266991360 7927773203 GLYOXYLIC ACID 4193315.999 4726187.342 6759800.863 3214257.897 3639301.461 1820649.569 2441768.779 2965023.11 2375765.028 3379358.3 3154034.405 2880585.776 3573279.292 3215051.764 3168126.977 3935119.179 7551529.249 442217.5037 3667939.799 6171420.036 4468727.316 2887336.147 3454302.758 3738594.791 5916282.387 GUANIDINOACETATE 146354393.8 131399378.7 139022057.8 99014860.21 114975874.2 132584888.5 154228473.5 94913249.85 111109337.4 140318950.6 114793187.1 100860407.3 107951587.6 100362772.6 89796456.9 86297021.66 113009756.1 61347322.26 37111733.34 149827764.2 80633763.77 71020338.89 49057432.4 49544050.78 114738702 GUANINE 2930463.41 3188907.318 3770292.93 1300344.64 1899021.571 1219288.128 229331.6221 1365218.554 169981.7592 1452573.617 1016852.073 1018829.786 103932.62 2649802.123 1389741.646 945743.1858 880177.66 3174138.568 774443.9931 1003493.23 525208.9131 2647915.086 40653757.48 139245.8427 1196833.394 GUANOSINE 165453741.5 122426836.3 67359834.51 68996923.07 84051568.19 40085900.15 60141688.92 109441613.7 64824322.48 75435710.99 73315427.46 48356426.82 56301761.84 3678668.656 4141837.489 2861552.832 5184080.145 25421916.89 2399499.896 3490871.478 3433018.022 18105410.85 46290421 1898952.401 4878735.717 GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 GUANOSINE 5'-DIPHOSPHATE 0 0 0 0 0 0 0 0 0 0 0 0 0 532164.3239 585738.8944 621946.3001 678589.8546 605868.3818 420992.8395 665674.9293 700652.2412 550938.0611 484074.2252 971510.0693 639853.0384 GUANOSINE 5'-DIPHOSPHOGLUCOSE 995476.7296 384998.5307 588599.857 129002.162 0 244733.2709 517136.0261 163174.0761 195755.9043 310758.3219 223741.875 732224.7384 329133.117 1315291.974 1567093.603 1222956.487 1474004.271 1182447.259 1308408.107 1520500.941 1151762.137 1095526.072 809163.0659 1054691.606 1271440.009 GUANOSINE 5'-MONOPHOSPHATE 59600691.25 28352708.9 69143559.7 17773721.1 4851513.491 9795350.356 14212347.82 19156083.08 9866932.084 23385799.77 32795874.03 60149747.47 17055532.18 140041831.9 153561970.6 141768816.9 127562425.1 133772921.6 98630656.86 134243856.8 127818199.6 111196590.2 1078030958 147932739.2 122849188.4 HEPTADECANOATE 1396490518 893001710.9 1079822011 844377155.6 1329545448 976544792.4 1199676654 877471786.9 1076572848 929365082.2 1304901008 1017151772 1186235458 925556160.9 856979209.8 754589057 893933438.1 508317688.9 355430330.6 700636833.1 765346059.5 279505904 687153979.3 308337876.5 628389003.1 HEPTANOIC ACID 27370153.97 36814238.79 25469383.85 21991882.01 24573707.11 23573277.58 22844188.57 25540297.84 25786682.45 27927323.83 25572552.66 25366553.1 29217122.19 7307445.444 7517018.539 8924424.546 6410532.684 12976574.71 17986966.87 7699491.8 8356222.024 16132202.73 8063249.081 13278901.8 8953585.739 HEXANOATE 57665528.19 76012212.49 60357413.66 47917811.11 48342434.93 68822930.48 56477510.96 43753931.59 59241814.54 64995807.62 62954658.2 51142012.67 61989913.75 16380901.64 14477974.98 18150214.34 13327667.57 45233833.76 67389228.8 16318342 18640531.07 62711004.84 17728997.09 54458923.82 39997841.73 HIPPURATE 21919365.5 32885143.69 19131686.14 19423827.25 19960840.04 11529522.46 8180215.242 18608868.99 11672142.32 17091526.06 8924092.071 12749400.16 14889066.67 5929222.199 13125640.01 6675602.778 11611138.98 3344089.1 2128979.309 7970976.374 13017008.07 8723919.669 17491315.23 3613149.754 4956424.66 HOMOCYSTEINE 124381.4197 1314156.645 358031.7212 810915.393 964727.8583 1687070.563 2062405.988 803922.2393 2189855.438 0 1211578.905 2037048.544 1224465.069 0 0 0 0 0 0 0 0 0 0 0 0 HYPOTAURINE 46198719.57 56418519.43 23229000.7 35985384.38 51108940.47 30630649.15 24715342.81 26600337.28 14617988 36502775.37 21161068.62 14861905.27 35753918.25 19180127.63 15379231.86 30496185.79 35346439.63 15470045.05 19978363.21 21905082.85 30281853.01 31570017.75 39939029.6 18139375.37 20115796.3 HYPOXANTHINE 10121864630 7499581351 7800328143 4520592410 5763540575 4249215504 3835269930 6400763575 4289020960 5623465612 5040050559 3783815193 3979258857 4731373276 4344013957 4030671711 6342687301 6558356605 4749630606 4804307861 4719098180 5621025116 4698357474 4294535403 7787405497 INDOLE-3-ETHANOL 0 0 0 0 0 0 0 0 0 0 0 0 0 4957721.877 5502367.05 4985634.504 4476406.396 5762218.391 5834570.165 7217590.724 5151685.47 5598281.343 5571501.906 5060075.03 6176878.938 INDOXYL SULFATE 45136547.51 44927025.95 45760362.6 56817732.59 35083511.15 14922675.62 37031807.68 27165863.76 11412040.76 38754078.7 14268849.24 17257315.72 23251557.5 17632712.15 11508578.36 18847412.99 14644002.46 19785961.81 9127515.354 15235147.22 18643461.8 18466939.65 23074459.62 18406158.25 3647436.801 INOSINE 4708538582 3650689174 3447539851 2041359262 2094326214 1501136907 1806266106 3296510678 1502265599 2241650605 2720530937 1828776378 1843142315 1591773873 1752657405 1424879445 2007352240 2036336320 1390977950 1454496110 1596801205 1935982949 1451988026 1128851063 2275131270 INOSINE 5'-MONOPHOSPHATE 1366737649 1458142132 1683648786 977850847.8 1084258463 883379934.3 994367320.5 1212642222 787427246.1 1338985338 1743149830 1338222427 1151727395 4379731928 4574674655 4587876243 4082593397 4067314251 4187197558 4177864432 4510889737 4097612272 4548919193 3824137095 3713683523 ITACONATE 0 0 0 0 0 0 0 0 0 0 0 0 0 17585472.98 18622277 24041821.31 41828165.21 16513936.14 12075218.06 29531934.5 23345502.43 14013415.8 19457805.02 14073128.42 26978510.27 KYNURENINE 3704987.924 9340689.559 4751209.93 3426214.809 1210859.145 4070938.452 3259320.295 3772324.272 2856815.989 3640564.034 3259320.307 8451918.336 4937682.502 0 0 0 0 0 0 0 0 0 0 0 0 L-Alanine 1739808937 1698719381 1501218567 1530433538 1619663101 1449452489 1435339129 1535929078 1336186444 1755228202 1537540137 1538073710 1551115995 1246254914 1278975361 1222925284 1407093669 1207095033 1146927428 1343228571 1321411989 1282445446 1388706563 1248060930 1311696959 L-ANSERINE 3199106189 2456783996 833940629.4 2837594594 2077023632 1972854237 2210590844 1855361406 1891321121 2544017229 2649543688 2342644634 2008575305 29569867743 29692481815 28660611740 14481387695 37452116242 27932421863 24255900207 31167850243 35392550686 30423628976 25879092705 17515893360 L-ARGININE 1214837562 924788404.9 1928914840 768648847.8 906368440.8 538961005.1 602324221.3 767893954.1 580209822.6 885759772.6 820375169.2 475942678.8 664887342 1055223222 1204962947 1112008815 1438866883 848803836.6 802131549.8 1945956621 1865179139 1000264101 1327936288 1090754930 1246263572 L-Argininosuccinic acid 11526165.36 2549773.038 11874322.16 779506.1798 353307.4021 714007.7988 774251.7746 1562034.607 509956.7201 1184420.755 2721965.708 3739922.748 1694828.959 5358416.891 4233479.924 5988808.197 11758465.31 2080650.234 3725685.363 14638896.76 10553375.23 6180944.549 6877654.506 10554392.34 15002183.45 L-ASPARAGINE 65691099.2 74448353.05 81115959.81 51570222.53 74271379.56 62883469.79 49069299.04 43993176.98 39526186.61 67829505.02 58898333.54 50917270.25 73444419.3 83567149.96 80005536.16 75710091.06 73218309.85 79948118.72 50135328.85 82212474.9 91181724.32 79224175.64 105265517.7 104288027.3 97341242.03 L-CARNITINE 36534687350 37215551889 32563977599 25033698461 31132305250 28571123115 29507628888 23642298260 17290349083 39966197114 38488750880 30549954524 29793009136 20960282318 23600924229 26093111893 25333473543 13114974081 17799905607 21952569393 23844353227 23763902566 21022298671 14888482538 28411466341 L-CYSTATHIONINE 3039748.464 1563715.437 2638414.386 150559.7055 299652.0742 298536.2904 632887.7288 919809.9339 283243.9003 0 2281324.902 3241380.613 1656809.691 363817.8946 286763.0392 205252.303 244683.0961 240206.4147 243535.0172 136974.0768 722257.1292 186339.2869 346817.392 581399.8466 34312.82357 L-CYSTEIC ACID 151740430.9 198839559.9 129000824.5 159748071.9 212863090.3 138890206.7 150684667 150957686.6 110386001.1 168762665.9 194865710.4 175848173.7 166180042.5 274472731.1 297801090.8 309140432.2 268439830.9 244367341.3 233010952.8 275779936.2 330366027.7 251794819.7 289900237.2 216004017.7 236754362.3 L-CYSTINE 1750840.284 2923537.57 714308.7589 1409863.843 4139978.196 3989025.683 1724232.575 777700.9311 1321460.085 1231951.301 939900.5798 1042824.184 2476970.464 127356.5411 67271.64898 55390.81545 149695.5781 319780.7323 354609.6606 384495.5046 157803.0374 366546.6863 87436.9224 718363.5121 747947.2382 L-Glutamic acid 1187892855 1474754948 1129202422 913114831.2 1402427152 1033360061 966162547.5 1008177236 973126233.3 1243103848 1138370506 966354475.2 1114904079 371828073.7 383832133.9 573944094.6 1276302871 486169784 454235099.4 982600272.2 990490441.6 726646403.9 584634866.6 453837561.1 937290127.2 L-Glutamine 2078982904 2289524251 2332364125 1808096239 3070842467 2476228829 2293451660 2490941446 2116095393 2470443167 2488290086 2669489139 2333978460 1471783063 1145758482 1747295161 2667635684 1596050555 1663650372 2417775051 2571944784 2506159432 2209210301 2038565869 2693457972 L-ISOLEUCINE 1113630636 1270132171 1962728821 750554176.9 655799290.4 639047318 767766322.9 755395366.9 717933012.9 853301907.2 946971459.6 868573241.6 985033791.1 1435706128 1395077300 1059561399 1120730293 1905206447 1457545467 1267665966 1355877531 1293305491 1372617482 1534800965 1569674365 L-Lactic acid 33048915134 35791904493 25936792441 26283379528 31646780389 17922809576 19718232534 31270987359 17178211101 24795227064 25196082793 29836890523 20602156465 71053254528 83340362833 78821480518 62422474125 48884670979 59153292415 66389434726 97245267791 69024236068 85338387650 48150853091 43164711529 L-LYSINE 446126863.2 393343288.5 633624776.4 291784559.2 417604004.2 153886199.8 236648044 310669645.6 192683066.4 314320065 286316140.9 233507361.1 217302543.2 436636342.6 597424742.6 543313938.3 674066387 355295470 409457987.9 1057071816 1007408971 557389740.8 661817878.7 649817061.2 723257113.9 L-METHIONINE 1097220379 1125940966 1106484067 657637801.3 482288419.3 532912886.8 727850309.8 622191588.4 534251900 790287911.5 830313450.6 839194077.2 847135551 1942692082 1995493665 1730508298 1276850985 1898923614 1104028467 1539892454 1875140660 1585921526 2101307769 1619738875 1551451951 L-PHENYLALANINE 217642807.3 287387977.8 214467143.8 162791422.1 218069661.9 148881045.8 130952368.9 193969274.3 101665654.3 189959477.4 151243567.9 220843838.8 130268126.9 317422156.8 311074408.7 293860015.6 291935406.4 224442331.1 165949998.2 258070702 361777219.7 237573963.2 313557414.1 243160533.8 240128888.8 L-PIPECOLIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 160568345.6 173815871.2 132134411.9 158470166.3 218048392.6 101281427.6 146486121.6 182938467.6 313276143.9 158797474.3 204764557.5 144511426.3 L-PROLINE 5723852897 5771443422 6240246151 3926266158 2460831105 2923235034 3265808884 4168381848 2351379926 4984278526 3798081780 3613282157 4178570690 4883336329 4877388170 4278977448 3505037436 5619751229 3577225688 4757656865 4848083252 6110018231 5610001350 5004119156 5362611248 L-RHAMNOSE 0 0 0 0 0 0 0 0 0 0 0 0 0 30404123.33 26432165.73 27908791.91 31711684.64 25541510.68 27310512.04 29815828.08 18784996.79 24842552.52 25653312.93 23647461.79 24251723.65 L-Serine 169386238.5 183160600.8 188473704.4 132551058.1 206307635.2 147592253.8 148732777.3 129334639.3 114665784.3 189740147.9 159785014.8 117350982.6 170006089.1 199347458.7 165177697.7 173441831.9 177733022.9 207016380.8 127314773 191259322.8 239578518.6 175826242 232532909.5 182924907.3 203803820.5 L-THREONINE 927105069 1127387417 438239467.3 749446694.9 860186317.4 348676188.6 562041396.1 782150186 383899132.7 973755642 891892948.8 685318290.3 885864479.6 486957479.2 456257185.9 480039108.5 508186705.1 873883963.3 265185692.6 506419323.7 590094213.9 842817452.7 668918450.8 464523751.7 433446393 L-TYROSINE 782685036.6 999189397.8 1023780550 482461695.2 600761976.3 694775621.6 555611996.7 463990619 337273944.8 682621552.6 495582983.1 488427594.5 522389975.6 457401871 509084550.6 311612636.4 334375985 1395677570 232356419.7 481216408 385500771.1 1122201448 479391826.7 192079962.4 277657038.3 LAURIC ACID 62711139.92 83913451.8 127503054.4 48062983.43 52749734.13 41480156.46 29510199.49 55961271.2 42922445.56 62232619.79 43296464.73 40023532.54 34632991.94 16835171.84 16108565.06 21985245.47 20888554.36 25113278.08 24085117.44 25665410.18 17450443.29 20138318.61 18922364.51 14212017 22013886.08 LAUROYLCARNITINE 48889195.07 53584024.42 38957642.61 52138300.18 47811249.07 53136317.52 39300577.87 42497587.25 45585082.02 53295913.21 48507864.18 53136649.86 56731728.99 9095745.628 10199327.47 15184611.81 8992305.05 17655516.96 12348168.83 16005643 13295007.3 14325279.42 12544550.85 8202852.562 15625524.14 LEUCINE 1741056917 2235015844 2600401460 1422976199 1538711625 1337955792 1137204171 1418640029 1166556072 1752282862 1358383981 1506681374 1427701398 2157078189 2047522585 1855341223 1772178139 2319576884 1595088337 1760278817 2053802394 1948944467 2094226730 1758134473 1673948324 LINOLEATE 494967884 448133330.3 693707477 408261665.7 397218087.7 193228059.1 151658558.6 873552793.4 287961811.1 329931574 241002629.7 190676672.1 165331570.4 2709316.022 22707726.78 10288695.41 64663084.12 3170225.209 5672119.594 22667862.68 5662246.345 17899396.71 14664248.38 7638076.945 12419832.96 LL-2,6-DIAMINOHEPTANEDIOATE 0 0 0 0 0 0 0 0 0 0 0 0 0 317798.1446 265352.9256 374019.9764 345696.7825 237114.5381 407885.1027 241913.5572 722723.1785 610127.3888 584201.2929 431435.0947 190464.379 MALEIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 49741776.87 54212430.08 59987579.6 55915204.85 53928832.26 42056237.78 65119207.78 63906641.83 51088651.95 58609382.67 35634598.4 65221303.09 Malic acid 2999762342 3173229729 3717756299 1488638463 1627865890 1747722569 1418930413 2365270687 1370020781 2230937248 2573175444 2067898540 2576040462 1694135788 1742238162 2339059192 3762376884 630984197.1 1621568576 2914184914 2638709121 1885886746 2143701969 2338948082 3099045389 MALONATE 43888483.82 55354113.06 74797901.35 29930713.23 65252249.16 47718258.66 69160092.62 81184443.33 62002221.61 71308753.12 92415835.14 44320460.51 45953325.22 11282964.51 10706109.47 19475968.99 12833795.84 15796359.22 9853940.763 18988595.26 17706394.55 10908198.77 19359932.54 8256046.681 19132094.28 MALTOSE 102245091.7 73475196.28 192297692.7 44723358.48 25355350.4 7573532.497 10736955.31 72889430.15 9299147.813 32496004.95 34693823.41 10249631.19 30587985.03 84226608.48 129256785.6 150579596.9 66381559.66 78833527.72 77856845.34 97330892.41 130996980.6 100816023.4 146963189.3 41468896.03 50705211.23 MANNITOL, D-SORBITOL 3157473.932 2531517.793 23584263.53 2587016.945 2679649.6 1276335.828 1454693.991 1781747.074 1209190.836 2014265.388 1765816.017 1662793.81 1919689.027 445871.8287 758387.3944 96911.81418 216539.0726 2180419.543 158542.2533 289405.1445 404740.4972 679007.4996 0 88155.21542 63647.34981 METHYL-2-OXOVALERIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 65200515.21 59987801.81 55375830.03 18927911.25 119476155.7 53665707.38 29044181.16 82788061.73 37498904.82 77862335.5 24875793.72 14062793.91 METHYL BETA-D-GALACTOSIDE 29796349.64 26074156.63 29423905.44 17214781.66 23982526.85 22928198.75 17562576.43 26840972.57 13338720.07 26103284.61 17744345.26 16582465.58 19327429.03 0 0 0 0 0 0 0 0 0 0 0 0 METHYL JASMONATE 37909161.99 38303991.07 26186249.62 38038540.68 37613913.56 35276017.39 36619815.64 36595253.69 38998808.57 46635798.25 37685483.76 36227888.88 34205630.42 14708958.99 19295535.72 16329741.3 11692870.28 26672497.15 20278475.59 21197757.9 17769361.03 27673266.37 19102652.25 17970340.39 26856575.22 METHYLMALONATE 17003797.76 13619940.01 26322400.08 11134207.79 9404296.503 6045794.014 7813040.277 10050078.52 4641052.592 2097348.215 8885203.853 5668758.851 11522421.81 8002752.568 7649098.697 9195988.503 9732707.278 5218687.73 4236822.981 6642153.052 9040903.745 4027371.043 9856377.216 3590886.211 3920848.515 MEVALOLACTONE 0 0 0 0 0 0 0 0 0 0 0 0 0 1843826.312 1351462.745 1639714.768 1571917.417 710670.7569 568543.5706 984233.5971 2244236.295 1763627.157 1808555.325 1739105.567 857622.6949 MYO-INOSITOL 288603435.7 354042634.8 227228474 263749449.6 696806422.6 165146848 294462547.4 258307557.4 202441095 284412032.8 252276483.9 241565256.4 176392042.2 24639381.15 26647585.99 26294880.07 31659012.2 29192761.59 22387949.63 29296101.73 31921011.94 26627089.98 38665863.39 25314506.77 28799419.42 MYRISTIC ACID 1828632710 2863245759 2033774845 2562660784 1578349683 2434940999 1438974886 2094707947 1981258990 2501651470 1715787203 2305196541 1986596739 1666799025 1527879984 1192695906 1661320090 917892495.3 1195916279 1163866449 1032568487 1131937001 916134797.5 1028624455 1090608129 N-ACETYL-DL-GLUTAMIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 2884720.362 719696.5226 3302304.939 4155852.874 1205459.653 474722.4399 3113294.569 2280884.211 2918590.581 4103437.845 1753468.241 2246720.423 N-ACETYL-DL-METHIONINE 5221179.398 5095604.622 4254570.847 2361361.641 3244089.928 1060629.446 1372281.5 3970153.795 1260161.997 3203343.283 1112936.61 1671525.793 1365414.3 21411418.52 22148363.15 17878854.07 6751104.169 38195892.32 13058616.5 10589801.78 14376266.25 14469056.06 12999350.19 9202878.874 4865278.664 N-ACETYL-DL-SERINE 24695661.58 25273431.84 37621486.28 20114602.68 27274330.81 18724823.06 17540092.7 16634078.58 13970058.95 19177141.68 14179297.65 17928445.08 21147960.73 86819096.39 90217877.44 82402015.8 35904929.73 88013519.34 71179428.91 43934863.59 74311782.24 59330370.39 86937772.8 89715169.5 49586428.51 N-ACETYL-L-ASPARTIC ACID 1717126898 1420590470 1562434813 1243505104 1145396762 1066916682 1058801148 1242949408 843087867.3 1196668526 1156676196 1414719681 1283619695 219301447.7 109190217.3 182547426.8 391828880.1 175002843.9 86591931.03 295931513.3 235231632.3 351320203.1 186529803.9 153491324.3 253721467.7 N-ACETYL-L-CYSTEINE 3789813.993 4591720.777 3335312.059 1771735.586 5163324.603 729333.5896 1867118.483 2128938.275 1052429.48 2842113.333 1056445.295 1596838.954 1707691.419 7696301.735 5849246.494 4656527.825 5613846.304 14692243.51 4496180.164 6174219.765 6352257.509 9629156.195 7454773.427 10740247.23 11811513.77 N-ACETYL-L-LEUCINE 0 0 0 0 0 0 0 0 0 0 0 0 0 743219.3168 1094500.672 522304.017 1369084.676 1552666.694 1845074.889 190501.9058 558124.1485 758181.7817 1383113.149 1345572.391 327239.7238 N-ACETYL-L-PHENYLALANINE 0 4362630.178 2780305.749 673379.844 1432885.801 924562.7409 878314.0144 238506.3235 661481.2545 1953794.361 703688.2657 1224433.89 1545546.727 803635.02 1023936.216 913551.6138 1504175.807 1196670.451 188521.959 234438.1854 596613.6952 1034620.222 1004168.711 836696.586 736840.1567 N-ACETYLGLYCINE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 359058.4856 0 4614431.963 0 0 351338.1965 292323.4855 0 5790434.407 2271259.993 N-ACETYLNEURAMINATE 28813796.28 27134064.64 22843585.11 15980947.3 23641047.98 11973025.98 15728242.71 20667839.59 10788871.11 17216850.24 18307053.42 18111933.48 15456736.95 2225789.343 2864304.747 3055618.621 4948647.362 6208258.114 1695264.889 5448460.441 3441301.379 11620121 4831206.108 1644450.062 4936449.808 N-ALPHA-ACETYL-L-ASPARAGINE 0 0 0 0 0 0 0 0 0 0 0 0 0 2964554.19 3533854.175 3578482.153 3275367.377 2544248.039 2682008.692 2160087.563 2216118.228 3241765.703 4366971.667 4295183.381 2483339.693 N-AMIDINO-L-ASPARTATE 1157788.6 1350149.062 1686946.211 689793.7504 2613513.949 338069.6263 2077914.917 573653.8218 1217217.915 2662950.084 1000679.964 1141451.247 1317136.205 464214.9538 629129.9005 525068.5091 921313.9255 529001.8834 118942.213 591637.5114 596845.4499 699260.0352 974275.2396 5737224.875 307043.089 N(PAI)-METHYL-L-HISTIDINE 0 0 0 0 0 0 0 0 0 0 0 0 0 610251653.2 569375185.2 550664802.3 328445056.4 570056594.3 460093988.1 407251584.1 500424826 516091113.2 482627873.7 441106110.8 317884446.7 N6-(DELTA2-ISOPENTENYL)-ADENINE 0 0 0 0 0 0 0 0 0 0 0 0 0 19677810.24 27493093.64 20701245.83 17176998.87 22782580.77 24369344.68 25120150.74 21742043.4 24636639.38 24658076.68 22600463.08 25293016.27 NAD 26818195.67 27035371.73 3908612.118 24446353.67 38269606.04 41526101.79 34016424.97 580571.5652 31303094.69 29847225.58 26079756.8 35472054.58 41352112.41 1435694.122 1585467.614 661359.275 945181.6025 0 2063070.874 847562.3346 592608.9404 0 494024.2945 986162.4537 0 NADH 3934943.765 6497880.308 83285.0593 1402257.49 6086645.891 3930264.844 8233855.754 0 4583302.297 2409293.085 3530871.966 7697885.598 7165064.817 0 0 0 0 0 0 0 0 0 0 0 0 NADP 551018.249 186687.7344 126888.031 0 85230.18682 0 189678.6776 0 0 0 561227.3349 58157.02557 154378.5362 281716.4055 286454.6901 348020.5356 113553.4276 248343.9578 191349.9818 412030.5318 377207.7766 228757.3824 286596.105 319053.6999 165562.9114 NEPSILON,NEPSILON,NEPSILON-TRIMETHYLLYSINE 17574052.17 22261205.71 42243043.63 11227736.48 52222146.11 15974711.92 28722753.34 37844136.83 24664154.22 27536584.8 43078782.13 20354306.71 15631215.11 183965790.8 324756614.9 215011299.8 135147478.4 158344279.1 164447304.4 176879789.5 382714683.1 173897426.3 333094253.4 246389807 142420603 Nicotinamide mononucleotide(NMN) 1882034.479 3985990.646 4051806.987 2089779.502 5350042.248 1120863.419 1470160.712 1399304.512 1845671.171 2357720.405 1639609.098 1371526.195 1394353.002 0 0 0 167106.5638 0 0 0 229701.1087 0 246792.3714 210889.4114 138313.7563 Nicotinamide(NAM) 0 0 0 0 0 0 0 0 0 0 0 0 0 2072995963 2432447992 2388738199 2779879295 2671247897 2330901013 2185046615 2399737539 2662833803 2304588427 1629583365 2738421252 Nicotinic acid(NA) 62651200.81 2761117.941 4795544.879 38746791.08 1185824.788 1408561.838 2867462.379 8813732.429 1713243.667 1452987.609 947844.8753 697711.2702 532855.2354 0 0 0 0 0 0 0 0 0 0 0 0 NONANOATE 174488864.7 191575951 132534773.5 97478223.51 184965850.1 121796479.2 119709683 146018541.2 110654487.9 123436167 169118819.1 94698959.04 171740776.7 34193535.15 27580252.8 34769380.85 43380683.43 52383392.4 37457619.16 42135286.69 43515618 32912776.07 38437405.01 34191776.79 24059004.78 O-ACETYL-L-CARNITINE 29647627243 37933078703 24686169114 19429897137 35490983093 30578601275 31991907390 20240455890 25247294721 34040784957 29831902845 35928069294 26746533337 36152855861 37623070863 40121108161 40558491820 26154640762 33033637822 36800658587 40223973728 36451849701 34561041092 28814255971 38227654003 O-SUCCINYL-L-HOMOSERINE 10599486.95 11289555.33 7767691.859 7297147.027 9288196.627 3286569.744 6268317.195 6546184.423 5654487.228 8178720.778 7984666.997 5017344.719 6436389.75 1304591.576 1775231.183 1466685.593 903628.1092 14721105.11 1363057.401 1682974.335 1835068.888 14472281.99 1325950.845 599492.7302 1735766.178 OLEATE 270790141.4 253742019.2 357030976.7 294274471.4 197593806 221132563.1 125487129.3 261027476.4 220280782.3 246859107.5 192746978 218553738.9 181238635.8 62419021.8 59306570.93 61526241.44 69517813.68 37348901.97 45312210.34 49362366.71 46691181.12 41961267.43 44128631.36 37487509.15 55367565.04 Oleoylethanolamide 7035931.495 8968333.978 13166204.46 7158425.491 10677200.2 7798377.093 6186342.322 6586731.232 5819189.659 8090101.123 11295863.43 8041587.056 5898874.779 0 0 0 0 0 0 0 0 0 0 0 0 OPHTHALMIC ACID 6841160.815 8093909.99 3888152.907 2904867.619 6273362.233 2780492.022 3117112.204 4236760.796 2613855.46 4929025.305 3073381.816 4750449.286 5098631.667 0 0 0 0 0 0 0 0 0 0 0 0 ORNITHINE 66720816.11 55216846.44 78096097.4 32905144.7 32787380.81 10689875.01 25922710.24 39004406.81 11163343.9 39419361.84 23139724.81 31242407.1 23611713.13 60732684.67 79181946.84 74583621.94 83139859.16 44906068.1 28788243.73 121088706.5 160820101 86601629.35 134370707.5 42881750 56826693.83 OROTATE 5011872.062 6028634.967 4684046.493 4079662.938 4599346.56 2345362.586 3533573.08 5066438.162 3590457.415 6432016.078 3132137.188 6697480.455 4698853.23 0 0 0 0 0 0 0 0 0 0 0 0 OXALIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 11587525.08 13215984.07 19878297.9 15392937.1 16492693.37 11893340.71 15124086.77 14424283.31 11097344.93 12302067.11 9784333.58 11490600.83 Oxidised Glutathione 56321601.45 19500602.49 53118320.44 5993488.537 12007275.55 4214919.259 15235466.7 9702456.183 8111143.994 10792847.36 17780662.3 22783624.09 9263577.209 13998543.58 15691034.15 13890166.53 21324493.92 7181184.05 8467628.792 16458695.65 21338991.77 12091225.74 10299621.56 5937408.627 9115898.394 PALMITATE 26852740057 23437360173 27032591954 21493864934 23478961395 24936770560 23027930795 21513971748 23360361590 22380417115 25568273167 26280471679 27573306446 24113337093 22442761925 18454632627 23208281400 13899692273 8120049376 18955626613 19750176420 5873695476 18788664432 8085965679 15606629165 PALMITOLEIC ACID 120458886 105544003.8 130306630.1 126670531 243015974.2 68786154.28 68581482.18 161012263.5 164450071 115666057.1 73399739.05 53613983.2 58662525.59 787421.6292 9097165.421 6140195.956 9471692.84 4335620.269 3454833.225 9999540.572 8362114.4 9365842.365 5451575.488 6024884.468 7027415.068 Palmitoylethanolamide 23273245.48 22725299.62 17016579.95 17802724.99 21528110.37 17198564.53 15336251.36 17053830.13 14526837.83 17543438.84 18340482.91 19387491.71 19284961.29 0 0 0 0 0 0 0 0 0 0 0 0 PENTANOATE 0 0 0 0 0 0 0 0 0 0 0 0 0 8224409.185 8845729.041 7981026.236 2289307.241 11370438.71 9386067.563 6039459.075 11875410.18 8745916.717 10146990.02 10433900.19 11412791.25 Phenylacetyl L-Glutamine 1533451.714 685527.9537 953152.5003 1089236.252 1818932.172 923115.3375 1527581.901 1144321.171 1758687.784 1728450.287 1390958.671 1127486.102 1448850.275 0 0 0 0 0 0 0 0 0 0 0 0 PHENYLPYRUVATE 0 0 776759.5161 146563.4215 0 483648.3828 142635.4125 0 0 289823.2521 0 202107.9218 0 309358.3114 0 0 0 470380.5015 0 0 428078.2437 0 357836.3551 0 183069.7957 PHOSPHO(ENOL)PYRUVIC ACID 22686663.73 159383.3732 0 133776.9823 0 0 619313.2877 430432.8649 0 0 248969.3491 1584308.109 0 0 0 0 0 0 0 0 0 0 0 0 0 PHOSPHOCHOLINE 1242112050 1195504569 1673306549 1030150141 1585558528 881915888.5 867700750.5 1351405072 948369556.6 1269377004 1038853978 918931768.1 778752359.6 1057548305 1137582553 982122614.6 1266438245 764258313.1 466315785.2 873554001.4 958344668.9 1032436022 1414962769 1293483535 742450889.3 PROPIONATE 0 29114924 0 21758501.98 0 19892286.35 0 0 0 0 0 0 0 8546902.438 16976971.13 6569208.344 5977676.258 53709755.97 57039839.85 24342356.99 10508216.9 55893890.04 13785605.59 54113311.95 48792837.72 PURINE 11766075.08 4453408.19 6991499.312 2084667.167 1741244.373 761085.4932 1046320.586 3014515.71 1031937.255 1399313.267 1338345.252 1127800.518 801769.8113 3871427.127 3084001.586 4336248.046 13926647.47 2088223.416 2341879.209 4765600.251 4259919.265 2899306.159 2713568.879 2134052.828 9527864.301 PYRIDOXAL 5278975.046 6810831.086 2377765.313 3849942.66 4136462.056 2623334.946 3422974.347 3842758.759 3323523.338 4806191.578 4311318.206 2805820.103 3581866.687 4234525.252 5256920.735 3703203.146 5880247.136 5020295.448 4932713.68 6218916.368 6361204.105 6671346.233 4916831.339 5755940.482 11140594.27 Pyruvic acid 190649158.2 152208093.2 167338905.2 139278527.7 287809255.5 70850038.61 145195020.2 628333831.8 88611173.79 117700677 345882917.6 128214863.4 96018953.38 404748395.3 576931275.7 299372049.3 76583098.06 820246258.6 361784146.4 120391743 222152605.6 337034350.6 566678299.8 71251412.24 81051382.38 RAC-GLYCEROL 1-MYRISTATE 3804143.408 2277493.907 1322126.067 3200753.561 4041189.869 2812154.458 3195347.101 2473846.085 3628002.544 3210532.695 3085739.011 2835208.791 3151859.363 0 0 0 0 0 0 0 0 0 0 0 0 RIBOFLAVIN 1863298.805 798019.5991 1873881.626 1325611.472 1103562.871 107622.9337 459330.6698 1274951.146 657701.7915 1092074.575 361595.2154 257326.7069 0 688692.6859 550792.3491 320422.4856 536684.1623 1358421.722 792563.0806 460681.8786 478948.2489 2270607.004 1032898.18 852440.1559 1943147.261 S-(5'-ADENOSYL)-L-HOMOCYSTEINE 166485076.3 121253022.9 47888613.69 92370710.16 70235865.2 37836794.84 53679567.67 101594023.2 54198657.63 73954571.97 65106811.61 45098613.38 42538758.32 48542871.33 41974296.45 50503344.26 46521385.21 105224929.6 37089764.05 49848455.3 42941634.02 82492987.38 39370089.13 28630568.38 41143862.46 S-(5'-ADENOSYL)-L-METHIONINE 15166511.62 25514757.38 12249597.13 77575567.26 91370269.98 47832194.28 68676900.89 50744493.05 57858183.49 74401018.03 17204969.46 11255909.19 21775840.38 30500529.09 37186530.75 27668567.24 23077994.01 19536600.01 34115081.66 31055285.27 24432878.52 23902936.43 48547673.26 45780000.57 27429541.96 SARCOSINE 32109583.71 36584883 0 14828800.82 12100953.24 6812446.735 8449182.747 16017515.28 7424617.793 21375174.49 14836638.06 27604009.74 21904094.17 15587489.14 16004414.74 15682831.97 19469139.85 22899492.03 12541899.7 16248309.64 26331592.54 35648957.77 22505049.52 9693354.136 14170741.33 SHIKIMATE 1997290.467 0 0 1148736.885 1461045.774 0 3384263.561 1773618.815 0 2666586.456 3610430.746 1633169.281 0 0 0 0 0 0 0 0 0 0 0 0 0 SN-GLYCEROL 3-PHOSPHATE 668737806.2 704395825.2 62372432.02 416506564.5 458626673.3 384964327.4 460092477.5 396455307.4 412484915.6 582090730.4 449806281.8 654760110.8 539246821 0 0 0 0 0 0 0 0 0 0 0 0 STACHYOSE 31452379.57 14385878.57 5053931.229 4437249.036 0 201696.6486 0 22140014.99 0 7998589.532 13864038.17 11192315.56 3054333.644 0 0 0 0 0 0 0 0 0 0 0 0 STEARATE 42073033173 5566584399 7375752485 4376429315 47049461141 8969586172 38552801043 12168338729 27688176812 8216213140 38113347117 8048243669 10621816532 0 0 0 0 0 0 0 0 0 0 0 0 SUBERIC ACID 16562903.57 9668265.192 8245476.816 9720771.169 14705306.49 9882849.483 11931169.69 12515333.07 16470560.32 16490282.1 17562837.53 9645616.802 11322891.78 0 0 0 0 0 0 0 0 0 0 0 0 Succinic acid 833016423.7 712571349.3 161105791 495929171.5 501581511.4 467025322.8 487050569.4 206510922.8 494429947.3 543378967 438245347.9 458886108 421297359 29011922.76 34936250.02 88586821.97 120780667 43327591.69 42467847.13 82453252.86 71424338.11 48855832.58 68014879.74 47016447.83 98767616.87 TAURINE 10039460276 10744245002 6899597172 9910242315 10577902640 8930673475 8945268846 9445355790 7911932481 9940641052 9590845947 10710393320 8779841765 8610797148 9231974121 9021295376 8354922516 9418223975 7891528894 8536836457 10411738440 9430681176 9784012339 7414246219 7706706936 THIAMINE MONOPHOSPHATE 1787557.273 1216790.024 1193017.667 1311566.647 1391741.436 363887.8651 276855.6456 1751475.731 286608.6283 539876.3598 114310.2947 219996.2786 440039.4281 1242400.728 753747.2092 1999202.408 3838612.619 634479.8997 850613.5508 2245474.105 1548566.762 1572698.186 1076132.912 1743957.921 2818239.001 THYMIDINE 2481264.145 4858939.115 3029915.333 1074468.726 1827431.447 2407520.787 1500523.125 2534119.146 896012.4179 1293108.65 1610001.099 2624021.346 1889988.301 2195771.444 3361471.417 2546316.057 4927104.248 1998340.28 0 6577463.186 1136860.731 1325266.996 4544600.353 0 1651364.104 THYMIDINE 5'-MONOPHOSPHATE 120408.8054 392898.9437 0 60848.16295 0 372185.7447 54823.94355 312557.2792 61396.61609 163744.7517 275846.4835 143226.8748 193408.5441 0 0 0 0 0 0 0 0 0 0 0 0 TRIGONELLINE 1786609756 1790532416 1419976715 1060414343 915454854.5 608668479.1 859061606.8 904649461.8 438634734.3 1286476616 836827475.6 1120045379 1056758254 951670513.4 1191502360 1141817804 1308792910 427577162.4 203228461.8 950925087.3 1426263713 1088263384 1272068553 839237257.9 599195839.6 TRYPTOPHAN 464114977.3 633621356.1 572549860.7 316058010 337758410.4 287547944.1 261440751.4 325731461.5 205065306.5 435568545.7 331256970.4 488275806.6 374669622.1 420076657.5 502666093.8 283319897 433101328.9 524795150.6 256448977.2 437798849.9 458670376 571932272.3 439249540.8 344214533.7 329818660.2 URACIL 108736557.3 146453091.5 58369462.43 52766109.64 127018059.8 30679006.35 43401087.07 92392383.69 46822041.57 70166029.65 36658051.62 53920638.14 34174802.05 3389450.04 3855117.258 2558766.087 7990223.293 8733778.798 2675170.153 4720854.016 5810858.379 6282261.955 9848834.116 11814061.72 17090897.41 Uric acid 272245756.5 333455712.4 442769871.8 283529273.3 216231680.4 235758875.9 182732208.6 254995362.6 274563639.5 251948973.4 162068348.7 203101114.3 276375916.8 19854221.88 18154113.29 16054571.93 18247045.73 98912677.8 16435087.12 21847138.3 21737788.64 102783403.6 31118289.28 31777301.17 31149147.66 URIDINE 126408359.2 128492831.5 94184904.78 80615303.87 137590776.4 71159202.6 76533388.42 103044356.8 72067045.72 83882053.17 84086721.35 94021408.54 67949839.58 53271257.11 55797154.32 49957106.72 59064979.77 94666335.16 32599495.16 46721054.6 55834066.7 67154727.21 56099717.35 38995745.05 60415694.21 URIDINE-5-MONOPHOSPHATE 30844895.03 54138863.28 47525793.23 40981033.01 51594865.32 25250474.42 25231641.78 19203754.97 26357469.36 52846684.6 39554266.8 35290581.45 22656413.79 57647516.93 56170723.37 61725656.57 44294730.71 38542324.13 47822172.34 64734738.67 68390917 55625267.62 71936183.15 49718231.73 44776488.88 URIDINE 5'-DIPHOSPHO-N-ACETYLGALACTOSAMINE/GLUCOSAMINE 28146540.43 33854704.04 42654383.05 17849493.93 51133415.87 16638354.23 21228988.17 18111771.4 16807622.23 23523400.44 22057191.44 22478006.66 19482505.95 0 0 0 0 0 0 0 0 0 0 0 0 URIDINE 5'-DIPHOSPHOGLUCOSE 6993411.375 4235533.604 4174829.403 584473.2909 1869372.615 879801.6089 2575329.145 874050.1667 1367761.697 0 3486330.134 8030317.306 3034379.563 1622402.627 2536839.656 2866206.853 0 2178320.406 1721807.493 968618.492 2991313.509 2723813.788 3441815.838 5426511.624 901004.1264 URIDINE 5'-DIPHOSPHOGLUCURONIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 0 369797.4352 919435.9594 228703.6688 928876.5862 255310.8925 739596.3817 261215.0402 229549.7432 748023.5731 242674.1443 0 VALINE 1892112097 2361360671 2681073433 2602818444 1663577434 1024933254 1938018647 2158170384 832506987.2 1852930773 1383227853 1452417143 1329505985 1885557036 1913133321 1382632092 1638467238 2061538567 1257682738 1865448112 2119058564 1900543145 1851298914 1068950369 1526460330 XANTHINE 700899143.1 615682171.4 485919708.2 432555043.6 539909818.8 261711488.6 268382950.6 587097362.9 278233221.8 367014649.3 278887155.6 339790914.2 264989457.4 172508834.1 175604879.8 161179758.7 225174405 229672096.4 150696461 195824319.4 200063929.6 245181969.6 201668066.1 151828474.7 294558299.8 XANTHOSINE 5'-MONOPHOSPHATE 0 0 0 0 0 0 0 0 0 0 0 0 0 330254.2788 418335.7151 282959.771 231890.6913 447931.2443 310291.8934 387380.4724 354930.6625 310871.4322 432857.893 435832.9426 385068.1909 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name (S)-NICOTINE 1-AMINOCYCLOPROPANE-1-CARBOXYLATE 1-HYDROXY-2-NAPHTHOATE 1-METHYLADENOSINE 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE 2-DEOXY-D-GLUCOSE 2-HYDROXY-4-(METHYLTHIO)BUTYRIC ACID 2-HYDROXYBUTYRIC ACID 2-METHYLGLUTARIC ACID 2,6-DIHYDROXYPYRIDINE 3-(2-HYDROXYPHENYL)PROPANOATE 3-(4-HYDROXYPHENYL)LACTATE 3-HYDROXY-3-METHYLGLUTARATE 3-HYDROXYBUTANOIC ACID 3-METHYLADENINE 3-METHYLHISTAMINE 3-UREIDOPROPIONATE 4-GUANIDINOBUTANOATE 4-HYDROXYPROLINE 4-IMIDAZOLEACETIC ACID 4-METHYL-2-OXO-PENTANOIC ACID 4-PYRIDOXATE 5'-METHYLTHIOADENOSINE 5-METHYLCYTOSINE HYDROCLORIDE 5-OXO-PROLINE 5-VALEROLACTONE 5,6-DIHYDROURACIL Acetic Acid Adenine Adenosine ADENOSINE 5'-DIPHOSPHORIBOSE(ADPR) Adenosine cyclic monophosphate(cAMP) Adenosine diphosphate(ADP) Adenosine monophosphate(AMP) Adenylosuccinic acid ALLANTOIN ALPHA-AMINOADIPATE ALPHA-D-GLUCOSE 1-PHOSPHATE ALPHA-KETOGLUTARIC ACID AMINOISOBUTANOATE ARACHIDIC ACID Aspartic acid BETAINE BIS(2-ETHYLHEXYL)PHTHALATE BUTANAL BUTANOATE CAPRYLIC ACID CARNOSINE CHOLATE cis-Aconitic acid CITRAMALATE CITRULLINE CMP COENZYME A CORTISONE CREATINE CREATINE PHOSPHATE CREATININE CYTIDINE CYTIDINE 5'-DIPHOSPHOCHOLINE CYTOSINE D-(+)-RAFFINOSE D-FRUCTOSE 6-PHOSPHATE D-GLUCOSAMINE 6-PHOSPHATE D-GLUCOSE-6-PHOSPHATE D-GLUCURONIC ACID D-MANNOSE 6-PHOSPHATE D-PANTOTHENIC ACID D-RIBOSE 5-PHOSPHATE DAMP DECANOATE DEOXYCARNITINE DEOXYCYTIDINE DEOXYURIDINE DIACETYL DIETHANOLAMINE DIHYDROXYACETONE PHOSPHATE DOCOSAHEXAENOIC ACID ERUCIC ACID ETHANOLAMINE PHOSPHATE FLAVIN ADENINE DINUCLEOTIDE FORMYL-L-METHIONYL PEPTIDE Fumaric acid GABA GALACTARATE GALACTITOL GAMMA-LINOLENIC ACID GLUCONIC ACID Glucose GLUTARIC ACID GLUTATHIONE GLYCERATE Glycerol 2-Phosphate Glycerol 3-Phosphate Glycine GLYCOLATE GLYOXYLIC ACID GUANIDINOACETATE GUANINE GUANOSINE GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE GUANOSINE 5'-DIPHOSPHATE GUANOSINE 5'-DIPHOSPHOGLUCOSE GUANOSINE 5'-MONOPHOSPHATE HEPTADECANOATE HEPTANOIC ACID HEXANOATE HIPPURATE HOMOCYSTEINE HYPOTAURINE HYPOXANTHINE INDOLE-3-ETHANOL INDOXYL SULFATE INOSINE INOSINE 5'-MONOPHOSPHATE ITACONATE KYNURENINE L-Alanine L-ANSERINE L-ARGININE L-Argininosuccinic acid L-ASPARAGINE L-CARNITINE L-CYSTATHIONINE L-CYSTEIC ACID L-CYSTINE L-Glutamic acid L-Glutamine L-ISOLEUCINE L-Lactic acid L-LYSINE L-METHIONINE L-PHENYLALANINE L-PIPECOLIC ACID L-PROLINE L-RHAMNOSE L-Serine L-THREONINE L-TYROSINE LAURIC ACID LAUROYLCARNITINE LEUCINE LINOLEATE LL-2,6-DIAMINOHEPTANEDIOATE MALEIC ACID Malic acid MALONATE MALTOSE MANNITOL, D-SORBITOL METHYL-2-OXOVALERIC ACID METHYL BETA-D-GALACTOSIDE METHYL JASMONATE METHYLMALONATE MEVALOLACTONE MYO-INOSITOL MYRISTIC ACID N-ACETYL-DL-GLUTAMIC ACID N-ACETYL-DL-METHIONINE N-ACETYL-DL-SERINE N-ACETYL-L-ASPARTIC ACID N-ACETYL-L-CYSTEINE N-ACETYL-L-LEUCINE N-ACETYL-L-PHENYLALANINE N-ACETYLGLYCINE N-ACETYLNEURAMINATE N-ALPHA-ACETYL-L-ASPARAGINE N-AMIDINO-L-ASPARTATE N(PAI)-METHYL-L-HISTIDINE N6-(DELTA2-ISOPENTENYL)-ADENINE NAD NADH NADP NEPSILON,NEPSILON,NEPSILON-TRIMETHYLLYSINE Nicotinamide mononucleotide(NMN) Nicotinamide(NAM) Nicotinic acid(NA) NONANOATE O-ACETYL-L-CARNITINE O-SUCCINYL-L-HOMOSERINE OLEATE Oleoylethanolamide OPHTHALMIC ACID ORNITHINE OROTATE OXALIC ACID Oxidised Glutathione PALMITATE PALMITOLEIC ACID Palmitoylethanolamide PENTANOATE Phenylacetyl L-Glutamine PHENYLPYRUVATE PHOSPHO(ENOL)PYRUVIC ACID PHOSPHOCHOLINE PROPIONATE PURINE PYRIDOXAL Pyruvic acid RAC-GLYCEROL 1-MYRISTATE RIBOFLAVIN S-(5'-ADENOSYL)-L-HOMOCYSTEINE S-(5'-ADENOSYL)-L-METHIONINE SARCOSINE SHIKIMATE SN-GLYCEROL 3-PHOSPHATE STACHYOSE STEARATE SUBERIC ACID Succinic acid TAURINE THIAMINE MONOPHOSPHATE THYMIDINE THYMIDINE 5'-MONOPHOSPHATE TRIGONELLINE TRYPTOPHAN URACIL Uric acid URIDINE URIDINE-5-MONOPHOSPHATE URIDINE 5'-DIPHOSPHO-N-ACETYLGALACTOSAMINE/GLUCOSAMINE URIDINE 5'-DIPHOSPHOGLUCOSE URIDINE 5'-DIPHOSPHOGLUCURONIC ACID VALINE XANTHINE XANTHOSINE 5'-MONOPHOSPHATE METABOLITES_END #END