#METABOLOMICS WORKBENCH gardinassi_20240301_092149 DATATRACK_ID:4683 STUDY_ID:ST003117 ANALYSIS_ID:AN005177 PROJECT_ID:PR001936 VERSION 1 CREATED_ON April 2, 2024, 11:37 pm #PROJECT PR:PROJECT_TITLE Metabolomics of patients with Plasmodium vivax malaria PR:PROJECT_SUMMARY Background: Malaria is the leading parasitic disease worldwide, with P. vivax PR:PROJECT_SUMMARY being a major challenge for its control. Several studies have indicated PR:PROJECT_SUMMARY metabolomics as a promising tool for combating the disease. Objective: The study PR:PROJECT_SUMMARY evaluated plasma metabolomic profiles of patients with recurrent and PR:PROJECT_SUMMARY non-recurrent P. vivax malaria in the Brazilian Amazon. Methods: Metabolites PR:PROJECT_SUMMARY extracted from the plasma of P. vivax-infected patients were subjected to LC-MS PR:PROJECT_SUMMARY analysis. Untargeted metabolomics was applied to investigate the metabolic PR:PROJECT_SUMMARY profile of the plasma in the two groups. Results: Overall, 51 recurrent and 59 PR:PROJECT_SUMMARY non-recurrent patients were included in the study. Longitudinal metabolomic PR:PROJECT_SUMMARY analysis revealed 52 and 37 significant metabolite features from the recurrent PR:PROJECT_SUMMARY and non-recurrent participants, respectively. Recurrence was associated with PR:PROJECT_SUMMARY disturbances in eicosanoid metabolism. Comparison between groups suggest PR:PROJECT_SUMMARY alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, PR:PROJECT_SUMMARY 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. PR:PROJECT_SUMMARY Integrative network analysis revealed enrichment of other metabolic pathways for PR:PROJECT_SUMMARY the recurrent phenotype, including the butanoate metabolism, aspartate and PR:PROJECT_SUMMARY asparagine metabolism, and N-glycan biosynthesis. Conclusion: The metabolites PR:PROJECT_SUMMARY and metabolic pathways predicted in our study suggest potential biomarkers of PR:PROJECT_SUMMARY recurrence and provide insights into targets for antimalarial development PR:PROJECT_SUMMARY against P. vivax. PR:INSTITUTE University of Sao Paulo PR:LAST_NAME Gardinassi PR:FIRST_NAME Luiz Gustavo PR:ADDRESS Av. dos Bandeirantes, 3900, Campus Unviversitário, Ribeirão Preto, SP, Brazil PR:EMAIL gardinassi@eerp.usp.br PR:PHONE 55 16 3315-3395 #STUDY ST:STUDY_TITLE Metabolomics of patients with Plasmodium vivax malaria ST:STUDY_SUMMARY Background: Malaria is the leading parasitic disease worldwide, with P. vivax ST:STUDY_SUMMARY being a major challenge for its control. Several studies have indicated ST:STUDY_SUMMARY metabolomics as a promising tool for combating the disease. Objective: The study ST:STUDY_SUMMARY evaluated plasma metabolomic profiles of patients with recurrent and ST:STUDY_SUMMARY non-recurrent P. vivax malaria in the Brazilian Amazon. Methods: Metabolites ST:STUDY_SUMMARY extracted from the plasma of P. vivax-infected patients were subjected to LC-MS ST:STUDY_SUMMARY analysis. Untargeted metabolomics was applied to investigate the metabolic ST:STUDY_SUMMARY profile of the plasma in the two groups. Results: Overall, 51 recurrent and 59 ST:STUDY_SUMMARY non-recurrent patients were included in the study. Longitudinal metabolomic ST:STUDY_SUMMARY analysis revealed 52 and 37 significant metabolite features from the recurrent ST:STUDY_SUMMARY and non-recurrent participants, respectively. Recurrence was associated with ST:STUDY_SUMMARY disturbances in eicosanoid metabolism. Comparison between groups suggest ST:STUDY_SUMMARY alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, ST:STUDY_SUMMARY 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. ST:STUDY_SUMMARY Integrative network analysis revealed enrichment of other metabolic pathways for ST:STUDY_SUMMARY the recurrent phenotype, including the butanoate metabolism, aspartate and ST:STUDY_SUMMARY asparagine metabolism, and N-glycan biosynthesis. Conclusion: The metabolites ST:STUDY_SUMMARY and metabolic pathways predicted in our study suggest potential biomarkers of ST:STUDY_SUMMARY recurrence and provide insights into targets for antimalarial development ST:STUDY_SUMMARY against P. vivax. ST:INSTITUTE University of Sao Paulo ST:LAST_NAME Gardinassi ST:FIRST_NAME Luiz Gustavo ST:ADDRESS Av. dos Bandeirantes, 3900, Campus Universitário, Ribeirão Preto, SP, Brazil ST:EMAIL gardinassi@eerp.usp.br ST:PHONE 55 16 3315-3395 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER Male and female #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS P217 ID_1 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_1.mzML SUBJECT_SAMPLE_FACTORS P143 ID_2 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_2.mzML SUBJECT_SAMPLE_FACTORS P191 ID_3 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_3.mzML SUBJECT_SAMPLE_FACTORS P271 ID_4 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_4.mzML SUBJECT_SAMPLE_FACTORS P151 ID_5 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_5.mzML SUBJECT_SAMPLE_FACTORS P134 ID_6 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_6.mzML SUBJECT_SAMPLE_FACTORS P131 ID_7 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_7.mzML SUBJECT_SAMPLE_FACTORS P396 ID_8 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_8.mzML SUBJECT_SAMPLE_FACTORS P035 ID_9 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_9.mzML SUBJECT_SAMPLE_FACTORS P166 ID_10 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_10.mzML SUBJECT_SAMPLE_FACTORS P274 ID_11 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_11.mzML SUBJECT_SAMPLE_FACTORS P214 ID_12 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_12.mzML SUBJECT_SAMPLE_FACTORS P429 ID_13 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_13.mzML SUBJECT_SAMPLE_FACTORS P351 ID_14 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_14.mzML SUBJECT_SAMPLE_FACTORS P092 ID_15 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_15.mzML SUBJECT_SAMPLE_FACTORS P311 ID_16 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_16.mzML SUBJECT_SAMPLE_FACTORS P111 ID_17 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_17.mzML SUBJECT_SAMPLE_FACTORS P380 ID_18 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_18.mzML SUBJECT_SAMPLE_FACTORS P123 ID_19 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_19.mzML SUBJECT_SAMPLE_FACTORS P176 ID_20 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_20.mzML SUBJECT_SAMPLE_FACTORS P276 ID_21 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_21.mzML SUBJECT_SAMPLE_FACTORS P084 ID_22 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_22.mzML SUBJECT_SAMPLE_FACTORS P217 ID_23 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_23.mzML SUBJECT_SAMPLE_FACTORS P258 ID_24 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_24.mzML SUBJECT_SAMPLE_FACTORS P197 ID_25 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_25.mzML SUBJECT_SAMPLE_FACTORS P225 ID_26 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_26.mzML SUBJECT_SAMPLE_FACTORS P296 ID_27 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_27.mzML SUBJECT_SAMPLE_FACTORS P044 ID_28 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_28.mzML SUBJECT_SAMPLE_FACTORS P005 ID_29 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_29.mzML SUBJECT_SAMPLE_FACTORS P234 ID_30 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_30.mzML SUBJECT_SAMPLE_FACTORS P095 ID_31 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_31.mzML SUBJECT_SAMPLE_FACTORS P351 ID_32 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_32.mzML SUBJECT_SAMPLE_FACTORS P030 ID_33 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_33.mzML SUBJECT_SAMPLE_FACTORS P244 ID_34 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_34.mzML SUBJECT_SAMPLE_FACTORS P181 ID_35 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_35.mzML SUBJECT_SAMPLE_FACTORS P186 ID_36 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_36.mzML SUBJECT_SAMPLE_FACTORS P443 ID_37 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_37.mzML SUBJECT_SAMPLE_FACTORS P018 ID_38 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_38.mzML SUBJECT_SAMPLE_FACTORS P322 ID_39 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_39.mzML SUBJECT_SAMPLE_FACTORS P364 ID_40 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_40.mzML SUBJECT_SAMPLE_FACTORS P427 ID_41 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_41.mzML SUBJECT_SAMPLE_FACTORS P323 ID_42 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_42.mzML SUBJECT_SAMPLE_FACTORS P355 ID_43 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_43.mzML SUBJECT_SAMPLE_FACTORS P096 ID_44 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_44.mzML SUBJECT_SAMPLE_FACTORS P042 ID_45 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_45.mzML SUBJECT_SAMPLE_FACTORS P155 ID_46 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_46.mzML SUBJECT_SAMPLE_FACTORS P033 ID_47 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_47.mzML SUBJECT_SAMPLE_FACTORS P157 ID_48 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_48.mzML SUBJECT_SAMPLE_FACTORS P284 ID_49 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_49.mzML SUBJECT_SAMPLE_FACTORS P147 ID_50 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_50.mzML SUBJECT_SAMPLE_FACTORS P151 ID_51 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_51.mzML SUBJECT_SAMPLE_FACTORS P096 ID_52 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_52.mzML SUBJECT_SAMPLE_FACTORS P042 ID_53 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_53.mzML SUBJECT_SAMPLE_FACTORS P317 ID_54 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_54.mzML SUBJECT_SAMPLE_FACTORS P443 ID_55 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_55.mzML SUBJECT_SAMPLE_FACTORS P188 ID_56 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_56.mzML SUBJECT_SAMPLE_FACTORS P207 ID_57 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_57.mzML SUBJECT_SAMPLE_FACTORS P240 ID_58 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_58.mzML SUBJECT_SAMPLE_FACTORS P145 ID_59 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_59.mzML SUBJECT_SAMPLE_FACTORS P285 ID_60 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_60.mzML SUBJECT_SAMPLE_FACTORS P143 ID_61 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_61.mzML SUBJECT_SAMPLE_FACTORS P113 ID_62 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_62.mzML SUBJECT_SAMPLE_FACTORS P019 ID_63 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_63.mzML SUBJECT_SAMPLE_FACTORS P016 ID_64 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_64.mzML SUBJECT_SAMPLE_FACTORS P053 ID_65 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_65.mzML SUBJECT_SAMPLE_FACTORS P360 ID_66 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_66.mzML SUBJECT_SAMPLE_FACTORS P005 ID_67 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_67.mzML SUBJECT_SAMPLE_FACTORS P169 ID_68 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_68.mzML SUBJECT_SAMPLE_FACTORS P084 ID_69 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_69.mzML SUBJECT_SAMPLE_FACTORS P015 ID_70 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_70.mzML SUBJECT_SAMPLE_FACTORS P061 ID_71 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_71.mzML SUBJECT_SAMPLE_FACTORS P265 ID_72 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_72.mzML SUBJECT_SAMPLE_FACTORS P357 ID_73 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_73.mzML SUBJECT_SAMPLE_FACTORS P258 ID_74 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_74.mzML SUBJECT_SAMPLE_FACTORS P171 ID_75 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_75.mzML SUBJECT_SAMPLE_FACTORS P083 ID_76 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_76.mzML SUBJECT_SAMPLE_FACTORS P243 ID_77 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_77.mzML SUBJECT_SAMPLE_FACTORS P021 ID_78 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_78.mzML SUBJECT_SAMPLE_FACTORS P166 ID_79 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_79.mzML SUBJECT_SAMPLE_FACTORS P274 ID_80 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_80.mzML SUBJECT_SAMPLE_FACTORS P360 ID_81 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_81.mzML SUBJECT_SAMPLE_FACTORS P053 ID_82 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_82.mzML SUBJECT_SAMPLE_FACTORS P317 ID_83 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_83.mzML SUBJECT_SAMPLE_FACTORS P184 ID_84 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_84.mzML SUBJECT_SAMPLE_FACTORS P296 ID_86 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_86.mzML SUBJECT_SAMPLE_FACTORS P163 ID_87 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_87.mzML SUBJECT_SAMPLE_FACTORS P277 ID_88 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_88.mzML SUBJECT_SAMPLE_FACTORS P197 ID_89 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_89.mzML SUBJECT_SAMPLE_FACTORS P322 ID_90 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_90.mzML SUBJECT_SAMPLE_FACTORS P343 ID_91 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_91.mzML SUBJECT_SAMPLE_FACTORS P131 ID_92 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_92.mzML SUBJECT_SAMPLE_FACTORS P021 ID_93 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_93.mzML SUBJECT_SAMPLE_FACTORS P323 ID_94 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_94.mzML SUBJECT_SAMPLE_FACTORS P277 ID_95 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_95.mzML SUBJECT_SAMPLE_FACTORS P337 ID_96 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_96.mzML SUBJECT_SAMPLE_FACTORS P111 ID_97 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_97.mzML SUBJECT_SAMPLE_FACTORS P357 ID_98 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_98.mzML SUBJECT_SAMPLE_FACTORS P018 ID_99 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_99.mzML SUBJECT_SAMPLE_FACTORS P353 ID_100 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_100.mzML SUBJECT_SAMPLE_FACTORS P384 ID_101 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_101.mzML SUBJECT_SAMPLE_FACTORS P188 ID_102 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_102.mzML SUBJECT_SAMPLE_FACTORS P063 ID_103 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_103.mzML SUBJECT_SAMPLE_FACTORS P360 ID_104 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_104.mzML SUBJECT_SAMPLE_FACTORS P256 ID_105 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_105.mzML SUBJECT_SAMPLE_FACTORS P024 ID_106 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_106.mzML SUBJECT_SAMPLE_FACTORS P296 ID_108 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_108.mzML SUBJECT_SAMPLE_FACTORS P145 ID_109 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_109.mzML SUBJECT_SAMPLE_FACTORS P010 ID_110 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_110.mzML SUBJECT_SAMPLE_FACTORS P015 ID_111 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_111.mzML SUBJECT_SAMPLE_FACTORS P243 ID_112 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_112.mzML SUBJECT_SAMPLE_FACTORS P343 ID_113 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_113.mzML SUBJECT_SAMPLE_FACTORS P061 ID_114 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_114.mzML SUBJECT_SAMPLE_FACTORS P042 ID_115 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_115.mzML SUBJECT_SAMPLE_FACTORS P257 ID_116 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_116.mzML SUBJECT_SAMPLE_FACTORS P343 ID_117 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_117.mzML SUBJECT_SAMPLE_FACTORS P203 ID_118 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_118.mzML SUBJECT_SAMPLE_FACTORS P176 ID_119 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_119.mzML SUBJECT_SAMPLE_FACTORS P220 ID_120 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_120.mzML SUBJECT_SAMPLE_FACTORS P134 ID_121 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_121.mzML SUBJECT_SAMPLE_FACTORS P018 ID_122 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_122.mzML SUBJECT_SAMPLE_FACTORS P257 ID_123 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_123.mzML SUBJECT_SAMPLE_FACTORS P217 ID_124 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_124.mzML SUBJECT_SAMPLE_FACTORS P214 ID_125 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_125.mzML SUBJECT_SAMPLE_FACTORS P184 ID_126 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_126.mzML SUBJECT_SAMPLE_FACTORS P188 ID_127 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_127.mzML SUBJECT_SAMPLE_FACTORS P031 ID_128 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_128.mzML SUBJECT_SAMPLE_FACTORS P396 ID_129 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_129.mzML SUBJECT_SAMPLE_FACTORS P030 ID_130 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_130.mzML SUBJECT_SAMPLE_FACTORS P096 ID_131 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_131.mzML SUBJECT_SAMPLE_FACTORS P205 ID_132 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_132.mzML SUBJECT_SAMPLE_FACTORS P281 ID_133 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_133.mzML SUBJECT_SAMPLE_FACTORS P220 ID_134 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_134.mzML SUBJECT_SAMPLE_FACTORS P355 ID_135 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_135.mzML SUBJECT_SAMPLE_FACTORS P258 ID_136 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_136.mzML SUBJECT_SAMPLE_FACTORS P120 ID_137 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_137.mzML SUBJECT_SAMPLE_FACTORS P172 ID_138 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_138.mzML SUBJECT_SAMPLE_FACTORS P079 ID_139 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_139.mzML SUBJECT_SAMPLE_FACTORS P124 ID_140 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_140.mzML SUBJECT_SAMPLE_FACTORS P259 ID_141 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_141.mzML SUBJECT_SAMPLE_FACTORS P328 ID_142 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_142.mzML SUBJECT_SAMPLE_FACTORS P311 ID_143 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_143.mzML SUBJECT_SAMPLE_FACTORS P211 ID_144 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_144.mzML SUBJECT_SAMPLE_FACTORS P020 ID_145 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_145.mzML SUBJECT_SAMPLE_FACTORS P429 ID_146 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_146.mzML SUBJECT_SAMPLE_FACTORS P192 ID_147 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_147.mzML SUBJECT_SAMPLE_FACTORS P207 ID_148 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_148.mzML SUBJECT_SAMPLE_FACTORS P120 ID_149 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_149.mzML SUBJECT_SAMPLE_FACTORS P084 ID_150 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_150.mzML SUBJECT_SAMPLE_FACTORS P239 ID_151 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_151.mzML SUBJECT_SAMPLE_FACTORS P134 ID_152 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_152.mzML SUBJECT_SAMPLE_FACTORS P009 ID_153 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_153.mzML SUBJECT_SAMPLE_FACTORS P203 ID_154 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_154.mzML SUBJECT_SAMPLE_FACTORS P024 ID_155 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_155.mzML SUBJECT_SAMPLE_FACTORS P251 ID_156 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_156.mzML SUBJECT_SAMPLE_FACTORS P155 ID_157 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_157.mzML SUBJECT_SAMPLE_FACTORS P311 ID_158 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_158.mzML SUBJECT_SAMPLE_FACTORS P277 ID_159 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_159.mzML SUBJECT_SAMPLE_FACTORS P285 ID_160 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_160.mzML SUBJECT_SAMPLE_FACTORS P176 ID_161 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_161.mzML SUBJECT_SAMPLE_FACTORS P244 ID_162 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_162.mzML SUBJECT_SAMPLE_FACTORS P353 ID_163 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_163.mzML SUBJECT_SAMPLE_FACTORS P177 ID_164 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_164.mzML SUBJECT_SAMPLE_FACTORS P020 ID_165 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_165.mzML SUBJECT_SAMPLE_FACTORS P116 ID_166 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_166.mzML SUBJECT_SAMPLE_FACTORS P031 ID_167 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_167.mzML SUBJECT_SAMPLE_FACTORS P284 ID_168 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_168.mzML SUBJECT_SAMPLE_FACTORS P145 ID_169 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_169.mzML SUBJECT_SAMPLE_FACTORS P140 ID_170 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_170.mzML SUBJECT_SAMPLE_FACTORS P199 ID_171 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_171.mzML SUBJECT_SAMPLE_FACTORS P092 ID_172 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_172.mzML SUBJECT_SAMPLE_FACTORS P035 ID_173 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_173.mzML SUBJECT_SAMPLE_FACTORS P157 ID_174 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_174.mzML SUBJECT_SAMPLE_FACTORS P147 ID_175 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_175.mzML SUBJECT_SAMPLE_FACTORS P281 ID_176 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_176.mzML SUBJECT_SAMPLE_FACTORS P443 ID_177 Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_177.mzML SUBJECT_SAMPLE_FACTORS P113 ID_178 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_178.mzML SUBJECT_SAMPLE_FACTORS P337 ID_179 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_179.mzML SUBJECT_SAMPLE_FACTORS P177 ID_180 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_180.mzML SUBJECT_SAMPLE_FACTORS P351 ID_181 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_181.mzML SUBJECT_SAMPLE_FACTORS P353 ID_182 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_182.mzML SUBJECT_SAMPLE_FACTORS P212 ID_183 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_183.mzML SUBJECT_SAMPLE_FACTORS P123 ID_184 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_184.mzML SUBJECT_SAMPLE_FACTORS P016 ID_185 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_185.mzML SUBJECT_SAMPLE_FACTORS P020 ID_186 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_186.mzML SUBJECT_SAMPLE_FACTORS P199 ID_187 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_187.mzML SUBJECT_SAMPLE_FACTORS P063 ID_188 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_188.mzML SUBJECT_SAMPLE_FACTORS P388 ID_189 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_189.mzML SUBJECT_SAMPLE_FACTORS P256 ID_190 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_190.mzML SUBJECT_SAMPLE_FACTORS P009 ID_191 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_191.mzML SUBJECT_SAMPLE_FACTORS P113 ID_192 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_192.mzML SUBJECT_SAMPLE_FACTORS P010 ID_193 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_193.mzML SUBJECT_SAMPLE_FACTORS P396 ID_194 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_194.mzML SUBJECT_SAMPLE_FACTORS P299 ID_195 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_195.mzML SUBJECT_SAMPLE_FACTORS P234 ID_196 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_196.mzML SUBJECT_SAMPLE_FACTORS P083 ID_197 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_197.mzML SUBJECT_SAMPLE_FACTORS P281 ID_198 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_198.mzML SUBJECT_SAMPLE_FACTORS P143 ID_199 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_199.mzML SUBJECT_SAMPLE_FACTORS P115 ID_200 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_200.mzML SUBJECT_SAMPLE_FACTORS P338 ID_201 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_201.mzML SUBJECT_SAMPLE_FACTORS P203 ID_202 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_202.mzML SUBJECT_SAMPLE_FACTORS P384 ID_203 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_203.mzML SUBJECT_SAMPLE_FACTORS P033 ID_204 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_204.mzML SUBJECT_SAMPLE_FACTORS P207 ID_205 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_205.mzML SUBJECT_SAMPLE_FACTORS P240 ID_206 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_206.mzML SUBJECT_SAMPLE_FACTORS P083 ID_207 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_207.mzML SUBJECT_SAMPLE_FACTORS P079 ID_208 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_208.mzML SUBJECT_SAMPLE_FACTORS P038 ID_209 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_209.mzML SUBJECT_SAMPLE_FACTORS P036 ID_210 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_210.mzML SUBJECT_SAMPLE_FACTORS P323 ID_211 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_211.mzML SUBJECT_SAMPLE_FACTORS P214 ID_212 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_212.mzML SUBJECT_SAMPLE_FACTORS P380 ID_213 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_213.mzML SUBJECT_SAMPLE_FACTORS P033 ID_214 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_214.mzML SUBJECT_SAMPLE_FACTORS P323 ID_215 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_215.mzML SUBJECT_SAMPLE_FACTORS P328 ID_216 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_216.mzML SUBJECT_SAMPLE_FACTORS P427 ID_217 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_217.mzML SUBJECT_SAMPLE_FACTORS P240 ID_218 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_218.mzML SUBJECT_SAMPLE_FACTORS P234 ID_219 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_219.mzML SUBJECT_SAMPLE_FACTORS P364 ID_220 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_220.mzML SUBJECT_SAMPLE_FACTORS P157 ID_221 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_221.mzML SUBJECT_SAMPLE_FACTORS P036 ID_222 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_222.mzML SUBJECT_SAMPLE_FACTORS P009 ID_223 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_223.mzML SUBJECT_SAMPLE_FACTORS P355 ID_224 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_224.mzML SUBJECT_SAMPLE_FACTORS P243 ID_225 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_225.mzML SUBJECT_SAMPLE_FACTORS P120 ID_226 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_226.mzML SUBJECT_SAMPLE_FACTORS P251 ID_227 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_227.mzML SUBJECT_SAMPLE_FACTORS P166 ID_228 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_228.mzML SUBJECT_SAMPLE_FACTORS P192 ID_229 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_229.mzML SUBJECT_SAMPLE_FACTORS P317 ID_230 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_230.mzML SUBJECT_SAMPLE_FACTORS P284 ID_231 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_231.mzML SUBJECT_SAMPLE_FACTORS P030 ID_232 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_232.mzML SUBJECT_SAMPLE_FACTORS P380 ID_233 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_233.mzML SUBJECT_SAMPLE_FACTORS P225 ID_234 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_234.mzML SUBJECT_SAMPLE_FACTORS P015 ID_235 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_235.mzML SUBJECT_SAMPLE_FACTORS P225 ID_236 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_236.mzML SUBJECT_SAMPLE_FACTORS P271 ID_237 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_237.mzML SUBJECT_SAMPLE_FACTORS P095 ID_238 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_238.mzML SUBJECT_SAMPLE_FACTORS P199 ID_239 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_239.mzML SUBJECT_SAMPLE_FACTORS P251 ID_240 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_240.mzML SUBJECT_SAMPLE_FACTORS P155 ID_241 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_241.mzML SUBJECT_SAMPLE_FACTORS P010 ID_242 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_242.mzML SUBJECT_SAMPLE_FACTORS P274 ID_243 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_243.mzML SUBJECT_SAMPLE_FACTORS P005 ID_244 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_244.mzML SUBJECT_SAMPLE_FACTORS P181 ID_245 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_245.mzML SUBJECT_SAMPLE_FACTORS P205 ID_246 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_246.mzML SUBJECT_SAMPLE_FACTORS P211 ID_247 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_247.mzML SUBJECT_SAMPLE_FACTORS P299 ID_248 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_248.mzML SUBJECT_SAMPLE_FACTORS P115 ID_249 Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_249.mzML SUBJECT_SAMPLE_FACTORS P256 ID_250 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_250.mzML SUBJECT_SAMPLE_FACTORS P429 ID_251 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_251.mzML SUBJECT_SAMPLE_FACTORS P191 ID_252 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_252.mzML SUBJECT_SAMPLE_FACTORS P259 ID_253 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_253.mzML SUBJECT_SAMPLE_FACTORS P328 ID_254 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_254.mzML SUBJECT_SAMPLE_FACTORS P019 ID_255 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_255.mzML SUBJECT_SAMPLE_FACTORS P240 ID_256 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_256.mzML SUBJECT_SAMPLE_FACTORS P169 ID_257 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_257.mzML SUBJECT_SAMPLE_FACTORS P172 ID_258 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_258.mzML SUBJECT_SAMPLE_FACTORS P140 ID_259 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_259.mzML SUBJECT_SAMPLE_FACTORS P124 ID_260 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_260.mzML SUBJECT_SAMPLE_FACTORS P239 ID_261 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_261.mzML SUBJECT_SAMPLE_FACTORS P140 ID_262 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_262.mzML SUBJECT_SAMPLE_FACTORS P239 ID_263 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_263.mzML SUBJECT_SAMPLE_FACTORS P338 ID_264 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_264.mzML SUBJECT_SAMPLE_FACTORS P240 ID_265 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_265.mzML SUBJECT_SAMPLE_FACTORS P370 ID_266 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_266.mzML SUBJECT_SAMPLE_FACTORS P079 ID_267 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_267.mzML SUBJECT_SAMPLE_FACTORS P124 ID_268 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_268.mzML SUBJECT_SAMPLE_FACTORS P265 ID_269 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_269.mzML SUBJECT_SAMPLE_FACTORS P092 ID_270 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_270.mzML SUBJECT_SAMPLE_FACTORS P244 ID_271 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_271.mzML SUBJECT_SAMPLE_FACTORS P116 ID_272 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_272.mzML SUBJECT_SAMPLE_FACTORS P063 ID_273 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_273.mzML SUBJECT_SAMPLE_FACTORS P271 ID_274 Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_274.mzML SUBJECT_SAMPLE_FACTORS P205 ID_275 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_275.mzML SUBJECT_SAMPLE_FACTORS P285 ID_276 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_276.mzML SUBJECT_SAMPLE_FACTORS P035 ID_277 Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_277.mzML SUBJECT_SAMPLE_FACTORS P095 ID_278 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_278.mzML SUBJECT_SAMPLE_FACTORS P276 ID_279 Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_279.mzML SUBJECT_SAMPLE_FACTORS P031 ID_280 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_280.mzML SUBJECT_SAMPLE_FACTORS P212 ID_281 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_281.mzML SUBJECT_SAMPLE_FACTORS P021 ID_282 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_282.mzML SUBJECT_SAMPLE_FACTORS P370 ID_283 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_283.mzML SUBJECT_SAMPLE_FACTORS P257 ID_284 Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_284.mzML SUBJECT_SAMPLE_FACTORS P276 ID_285 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_285.mzML SUBJECT_SAMPLE_FACTORS P337 ID_286 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_286.mzML SUBJECT_SAMPLE_FACTORS P147 ID_287 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_287.mzML SUBJECT_SAMPLE_FACTORS P115 ID_288 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_288.mzML SUBJECT_SAMPLE_FACTORS P061 ID_289 Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_289.mzML SUBJECT_SAMPLE_FACTORS P265 ID_290 Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_290.mzML SUBJECT_SAMPLE_FACTORS P111 ID_291 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_291.mzML SUBJECT_SAMPLE_FACTORS P163 ID_292 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_292.mzML SUBJECT_SAMPLE_FACTORS P171 ID_293 Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_293.mzML SUBJECT_SAMPLE_FACTORS P181 ID_294 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_294.mzML SUBJECT_SAMPLE_FACTORS P131 ID_295 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_295.mzML SUBJECT_SAMPLE_FACTORS P019 ID_296 Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_296.mzML SUBJECT_SAMPLE_FACTORS P172 ID_297 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_297.mzML SUBJECT_SAMPLE_FACTORS P186 ID_298 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_298.mzML SUBJECT_SAMPLE_FACTORS P145 ID_299 Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_299.mzML SUBJECT_SAMPLE_FACTORS P038 ID_300 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_300.mzML SUBJECT_SAMPLE_FACTORS P145 ID_301 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_301.mzML SUBJECT_SAMPLE_FACTORS P163 ID_302 Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_302.mzML SUBJECT_SAMPLE_FACTORS P197 ID_303 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_303.mzML SUBJECT_SAMPLE_FACTORS P116 ID_304 Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_304.mzML SUBJECT_SAMPLE_FACTORS P044 ID_305 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_305.mzML SUBJECT_SAMPLE_FACTORS P364 ID_306 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_306.mzML SUBJECT_SAMPLE_FACTORS P177 ID_307 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_307.mzML SUBJECT_SAMPLE_FACTORS P123 ID_308 Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_308.mzML SUBJECT_SAMPLE_FACTORS P212 ID_309 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_309.mzML SUBJECT_SAMPLE_FACTORS P171 ID_310 Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_310.mzML SUBJECT_SAMPLE_FACTORS P016 ID_311 Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_311.mzML SUBJECT_SAMPLE_FACTORS P184 ID_312 Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_312.mzML SUBJECT_SAMPLE_FACTORS P192 ID_313 Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_313.mzML SUBJECT_SAMPLE_FACTORS P220 ID_314 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_314.mzML SUBJECT_SAMPLE_FACTORS P357 ID_315 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_315.mzML SUBJECT_SAMPLE_FACTORS P191 ID_316 Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_316.mzML SUBJECT_SAMPLE_FACTORS P038 ID_317 Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_317.mzML SUBJECT_SAMPLE_FACTORS P044 ID_318 Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_318.mzML SUBJECT_SAMPLE_FACTORS P370 ID_319 Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_319.mzML SUBJECT_SAMPLE_FACTORS P384 ID_320 Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_320.mzML SUBJECT_SAMPLE_FACTORS P024 ID_321 Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma RAW_FILE_NAME(RawFileName)=ID_321.mzML #COLLECTION CO:COLLECTION_SUMMARY Individuals with P. vivax were admitted at the Fundação de Medicina Tropical CO:COLLECTION_SUMMARY Dr. Heitor Vieira Dourado (FMT-HVD), a reference center for infectious diseases CO:COLLECTION_SUMMARY located in Manaus, Western Brazilian Amazon. At inclusion into the CURAVIVAX CO:COLLECTION_SUMMARY study, patient socio-demographic data including sex, age, weight, body-mass CO:COLLECTION_SUMMARY index and ethnicity was captured. Laboratory analyses were done at pre-treatment CO:COLLECTION_SUMMARY through the treatment days and follow-up including the day of recurrence. CO:COLLECTION_SUMMARY Patients of both sexes, aged > 6 months, body weight ≥ 5 kg, with symptomatic CO:COLLECTION_SUMMARY P. vivax monoinfection, parasite density between 100 and 100,000 parasites/ µL CO:COLLECTION_SUMMARY were included. Exclusion criteria included the use of antimalarials in the last CO:COLLECTION_SUMMARY 60 days, mixed Plasmodium infections especially P. falciparum, pregnancy, or CO:COLLECTION_SUMMARY lactation and concomitant or underlying diseases. Patients with dengue and other CO:COLLECTION_SUMMARY febrile diseases were excluded during screening. After confirmation of malaria CO:COLLECTION_SUMMARY vivax by thick blood smears, whole blood and plasma samples were collected, CO:COLLECTION_SUMMARY aliquoted and stored at -80OC until needed for analysis. Plasma samples for day CO:COLLECTION_SUMMARY of inclusion and before treatment (D0), day six (D6), day ninety (D90) and CO:COLLECTION_SUMMARY recurrence day (DR) were used for this study. CO:SAMPLE_TYPE Blood (plasma) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Patients were randomly assigned to one of four treatment groups: Group1- TR:TREATMENT_SUMMARY chloroquine (CQ) for 3 days + primaquine (PQ) for 14 days (0.50mg/kg/day) TR:TREATMENT_SUMMARY concurrently. Group 2 - dihydroartemisinin/piperaquine (DHA/PPQ) for 3 days + PQ TR:TREATMENT_SUMMARY for 14 days (0.50mg/kg/day) concurrently, Group 3 - CQ for 3 days + PQ for 14 TR:TREATMENT_SUMMARY days (0.50mg/kg/day) starting on day 42 after the initial CQ, and Group 4 - TR:TREATMENT_SUMMARY DHA/PPQ for 3 days + PQ for 14 days (0.50mg/kg/day) starting on day 42 after the TR:TREATMENT_SUMMARY initial DHA/PPQ. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Metabolites were extracted from 150 µL of sample (plasma EDTA), which was mixed SP:SAMPLEPREP_SUMMARY with acetonitrile (2:1, v/v; -5 °C) and centrifuged at 15,000 rpm for 15 min to SP:SAMPLEPREP_SUMMARY remove proteins. Stable isotopes caffeine-¹³C3, tyrosine-15N and SP:SAMPLEPREP_SUMMARY progesterone-d9 were used as internal standards. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY The binary mobile phases were water 0.5% formic acid with 5 mM of ammonium CH:CHROMATOGRAPHY_SUMMARY formate (A), and acetonitrile (B). Their gradient elution started with 20% (B) CH:CHROMATOGRAPHY_SUMMARY for 5 min, then linearly increased to 100% (B) in 30 min and kept constant for 8 CH:CHROMATOGRAPHY_SUMMARY min in 100% (B). The eluent was restored to the initial conditions in 4 minutes CH:CHROMATOGRAPHY_SUMMARY to re-equilibrate the column and held for the remaining 8 minutes. The flow rate CH:CHROMATOGRAPHY_SUMMARY was kept at 0.5 mL min-1. The injection volume for analysis was 3 μL, and the CH:CHROMATOGRAPHY_SUMMARY column temperature was set at 35 °C. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1220 Infinity CH:COLUMN_NAME Agilent ZORBAX Eclipse Plus C18 (100 x 4.6mm,3.5um) CH:SOLVENT_A 100% water; 0.5% formic acid; 5 mM of ammonium formate CH:SOLVENT_B 100% acetonitrile CH:FLOW_GRADIENT gradient elution started with 20% (B) for 5 min, then linearly increased to 100% CH:FLOW_GRADIENT (B) in 30 min and kept constant for 8 min in 100% (B). The eluent was restored CH:FLOW_GRADIENT to the initial conditions in 4 minutes to re-equilibrate the column and held for CH:FLOW_GRADIENT the remaining 8 minutes. CH:FLOW_RATE 0.5 mL/min CH:COLUMN_TEMPERATURE 35 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS The electrospray ionization was operating with the following settings: spray MS:MS_COMMENTS voltage 3.5 kV; capillary temperature: 269 °C; S-lens RF level 50 V; sheath gas MS:MS_COMMENTS flow rate at 53 L min-1; aux gas flow rate at 14 L min-1; sweep gas flow rate 3 MS:MS_COMMENTS L min-1. The high-resolution mass-spectrometry was obtained under full MS/dd-MS2 MS:MS_COMMENTS mode. The mass range in the full MS scanning experiments was m/z 80-1200. The MS:MS_COMMENTS max IT was set at 200 ms, and AGC target was set at 1 x 106. Resolving power was MS:MS_COMMENTS set at 140,000. MS:MS_RESULTS_FILE ST003117_AN005177_Results.txt UNITS:normalized intensity Has m/z:Yes Has RT:Yes RT units:Seconds #END