#METABOLOMICS WORKBENCH akoeberle_20240612_030840 DATATRACK_ID:4912 STUDY_ID:ST003261 ANALYSIS_ID:AN005345 PROJECT_ID:PR002023 VERSION 1 CREATED_ON June 14, 2024, 1:45 am #PROJECT PR:PROJECT_TITLE Iron(III)-salophene catalyzes redox cycles that induce phospholipid peroxidation PR:PROJECT_TITLE and deplete cancer cells of ferroptosis-protecting cofactors PR:PROJECT_SUMMARY Ferroptosis, regulated by glutathione peroxidase 4 and redox cycles, offers new PR:PROJECT_SUMMARY cancer treatment strategies. PR:PROJECT_SUMMARY Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes (SCs, PR:PROJECT_SUMMARY compounds 1-3) exhibit potent anti-cancer effects by inducing ferroptosis, PR:PROJECT_SUMMARY apoptosis, or necroptosis, including in therapy-resistant cancers. Our study PR:PROJECT_SUMMARY shows that SCs favor ferroptosis in triple-negative breast cancer cells and are PR:PROJECT_SUMMARY effective against invasive, chemo- or radioresistant cell lines. Redox PR:PROJECT_SUMMARY lipidomics indicates that SCs initiate cell death through extensive oxidation of PR:PROJECT_SUMMARY arachidonic and adrenic acids in membrane phospholipids. Mechanistically, SCs PR:PROJECT_SUMMARY catalyze one-electron transfer reactions, reducing Fe(III) to Fe(II), forming PR:PROJECT_SUMMARY oxo-bridged dimers, and generating organic radicals using hydrogen peroxide. PR:PROJECT_SUMMARY This process depletes NADPH, oxidizes membrane phospholipids, and disrupts PR:PROJECT_SUMMARY cellular detoxification of phospholipid hydroperoxides. PR:INSTITUTE University of Innsbruck PR:LAST_NAME Koeberle PR:FIRST_NAME Andreas PR:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria PR:EMAIL Andreas.Koeberle@uibk.ac.at PR:PHONE +43 512 507 57903 PR:FUNDING_SOURCE Austrian Science Fund (FWF) (P 36299), Phospholipid Research Center Heidelberg PR:FUNDING_SOURCE (AKO-2022-100/2-2) PR:PUBLICATIONS in revision PR:CONTRIBUTORS Fengting Su, Andreas Koeberle #STUDY ST:STUDY_TITLE Exploration of RSL3 or ST:STUDY_TITLE Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complex-induced ST:STUDY_TITLE changes in the phospholipid oxidation of MDA-MB-231 breast cancer cells ST:STUDY_SUMMARY Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes (SCs) ST:STUDY_SUMMARY exhibit potent anti-cancer properties through incompletely understood molecular ST:STUDY_SUMMARY mechanisms. Here, we treated human MDA-MB-231 triple-negative breast cancer ST:STUDY_SUMMARY cells with the glutathione peroxidase (GPX)4 inhibitor RSL3 or ST:STUDY_SUMMARY chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes (SCs) ST:STUDY_SUMMARY and analyzed their oxidized phospholipid profile by targeted lipidomics. SCs ST:STUDY_SUMMARY induce extensive (hydroper)oxidation of arachidonic acid and adrenic acid in ST:STUDY_SUMMARY membrane phospholipids, particularly phosphatidylethanolamines (PE) and ST:STUDY_SUMMARY phosphatidylinositols (PC). In this process, SCs have demonstrated superior ST:STUDY_SUMMARY efficacy compared to the GPX4 inhibitor RSL3, an established ferroptosis ST:STUDY_SUMMARY inducer. Please note that one sample set was measured three times with the same ST:STUDY_SUMMARY sample-ID, but with different methods (oxPE, oxPC, oxPI), therefore each ST:STUDY_SUMMARY sub-class has their own raw-data file marked by their corresponding abbreviation ST:STUDY_SUMMARY (oxPE, oxPC, oxPI; e.g. ST:STUDY_SUMMARY "210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff", ST:STUDY_SUMMARY "210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff", ST:STUDY_SUMMARY "210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff", ST:STUDY_SUMMARY "210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff" or ST:STUDY_SUMMARY "210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff", ). ST:INSTITUTE University of Innsbruck ST:LAST_NAME Koeberle ST:FIRST_NAME Andreas ST:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria ST:EMAIL Andreas.Koeberle@uibk.ac.at ST:PHONE +43 512 507 57903 #SUBJECT SU:SUBJECT_TYPE Cultured cells SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_2h_DMSO_1 Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_2h_RSL3_1uM_2 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_2h_RSL3_10uM_3 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_4h_DMSO_4 Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_4h_RSL3_1uM_5 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_4h_RSL3_10uM_6 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_6h_DMSO_7 Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_6h_RSL3_1uM_8 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_6h_RSL3_10uM_9 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_24h_DMSO_10 Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_24h_RSL3_1uM_11 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n1_24h_RSL3_10uM_12 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_2h_DMSO_13 Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_2h_RSL3_1uM_14 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_2h_RSL3_10uM_15 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_4h_DMSO_16 Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_4h_RSL3_1uM_17 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_4h_RSL3_10uM_18 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_6h_DMSO_19 Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_6h_RSL3_1uM_20 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_6h_RSL3_10uM_21 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_24h_DMSO_22 Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_24h_RSL3_1uM_23 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n2_24h_RSL3_10uM_24 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_2h_DMSO_25 Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_2h_RSL3_1uM_26 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_2h_RSL3_10uM_27 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_4h_DMSO_28 Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_4h_RSL3_1uM_29 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_4h_RSL3_10uM_30 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_6h_DMSO_31 Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_6h_RSL3_1uM_32 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_6h_RSL3_10uM_33 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_24h_DMSO_34 Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_24h_RSL3_1uM_35 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210309_MDA_Timecourse_RSL3_n3_24h_RSL3_10uM_36 Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h RAW_FILE_NAME(Raw file name for oxPE)=210309_MDA_Timecourse_RSL3_oxPE_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210309_MDA_Timecourse_RSL3_oxPC_dil_UD_Std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=- SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_DMSO_T41 Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_T42 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_Ferrostatin1_3uM_T43 Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_1uM_T44 Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_3uM_T45 Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_10uM_T46 Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_1uM_T47 Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_3uM_T48 Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_10uM_T49 Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_1uM_T50 Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_3uM_T51 Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_10uM_T52 Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_DMSO_T53 Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_T54 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_Ferrostatin1_3uM_T55 Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_1uM_T56 Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_3uM_T57 Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_10uM_T58 Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_1uM_T59 Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_3uM_T60 Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_10uM_T61 Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_1uM_T62 Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_3uM_T63 Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_10uM_T64 Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_DMSO_T65 Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_T66 Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_Ferrostatin1_3uM_T67 Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_1uM_T68 Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_3uM_T69 Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_10uM_T70 Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_1uM_T71 Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_3uM_T72 Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_10uM_T73 Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_1uM_T74 Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_3uM_T75 Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff SUBJECT_SAMPLE_FACTORS - 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_10uM_T76 Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h RAW_FILE_NAME(Raw file name for oxPE)=210324_Rescue_Gust_compounds_oxPE_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPC)=210324_Rescue_Gust_compounds_oxPC_dil_UD_std_1ul_SFT.wiff; RAW_FILE_NAME(Raw file name for oxPI)=210324_Rescue_Gust_compounds_oxPI_dil_UD_std_1ul_SFT.wiff #COLLECTION CO:COLLECTION_SUMMARY Cultured cells were washed, trypsinized, counted and flash-frozen in liquid N2 CO:COLLECTION_SUMMARY and stored at -80°C. CO:SAMPLE_TYPE Breast cancer cells CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Treatment of brest cancer cells (MDA-MB-231 cells) for the analysis of oxidized TR:TREATMENT_SUMMARY phosphatidylethanolamine (oxPE), oxidized phosphatidylcholine (oxPC), and TR:TREATMENT_SUMMARY oxidized phosphatidylinositol (oxPI): Human MDA-MB-231 breast cancer cells were TR:TREATMENT_SUMMARY treated with vehicle (DMSO) or RSL3 (1 or 10 µM) with or without ferrostatin-1 TR:TREATMENT_SUMMARY (3 µM) for 2 h, 4 h, 6 h, or 24 h or with SCs (1, 3, and 10 µM) for 2 h at TR:TREATMENT_SUMMARY 37°C and 5% CO2. Cells were harvested, washed with PBS pH 7.4, snap-frozen, and TR:TREATMENT_SUMMARY stored at -80°C. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Phospholipids were extracted from cell pellets by successive addition of PBS pH SP:SAMPLEPREP_SUMMARY 7.4, methanol, chloroform, and saline to a final ratio of 14:34:35:17. SP:SAMPLEPREP_SUMMARY Evaporation of the organic layer yielded a lipid film that was dissolved in SP:SAMPLEPREP_SUMMARY methanol and subjected to UPLC-MS/MS. SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Chromatographic separation of phospholipids was carried out on an Acquity BEH C8 CH:CHROMATOGRAPHY_SUMMARY column (1.7 μm, 130 Å, 2.1×100 mm, Waters, Milford, MA) using an ExionLC CH:CHROMATOGRAPHY_SUMMARY UHPLC system. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Waters Acquity H-Class CH:COLUMN_NAME Waters ACQUITY UPLC BEH C8 (100 x 2.1mm,1.7um) CH:SOLVENT_A water/acetonitrile 90/10, 2 mM ammonium acetate CH:SOLVENT_B water/acetonitrile 5/95, 2 mM ammonium acetate CH:FLOW_GRADIENT The gradient was ramped from 75 to 85% B over 5 min and further increased to CH:FLOW_GRADIENT 100% B within 2 min, followed by isocratic elution for another 2 min. CH:FLOW_RATE 0.75 ml/min CH:COLUMN_TEMPERATURE 45°C #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 6500+ MS:INSTRUMENT_TYPE QTRAP MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Targeted MRM with pre-optimized settings and subsequent automated integration of MS:MS_COMMENTS selected signals using Analyst 1.6.3 or Analyst 1.7.1 (Sciex). Oxidized MS:MS_COMMENTS phospholipid anions (PE and PI: [M-H]-; PC: [M+OAc]-) were detected after MS:MS_COMMENTS fragmentation to both fatty acid anions. Retention time windows for oxidized PC MS:MS_COMMENTS and oxidized PE were predicted based on the analysis of oxidized PC(16:0/20:4) MS:MS_COMMENTS (oxPAPC) (Avanti Polar Lipids, Alabaster, AL; 1[O]: 2.8–4.6 min; 2[O]: MS:MS_COMMENTS 2.9–4.3 min; 3[O]: 1.45–2.3 min). Quantitation is based on the most intense MS:MS_COMMENTS signals of oxidized fatty acid anion fragments. The fractions of phospholipids MS:MS_COMMENTS with one 1[O], two 2[O], or three oxygens 3[O] incorporated comprise multiple MS:MS_COMMENTS isomeric species that were summed and normalized to DMPC (for oxidized PC and MS:MS_COMMENTS oxidized PI) or DMPE (for oxidized PE) and cell number. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS absolute intensities MS_METABOLITE_DATA_START Samples 210309_MDA_Timecourse_RSL3_n1_2h_DMSO_1 210309_MDA_Timecourse_RSL3_n1_2h_RSL3_1uM_2 210309_MDA_Timecourse_RSL3_n1_2h_RSL3_10uM_3 210309_MDA_Timecourse_RSL3_n1_4h_DMSO_4 210309_MDA_Timecourse_RSL3_n1_4h_RSL3_1uM_5 210309_MDA_Timecourse_RSL3_n1_4h_RSL3_10uM_6 210309_MDA_Timecourse_RSL3_n1_6h_DMSO_7 210309_MDA_Timecourse_RSL3_n1_6h_RSL3_1uM_8 210309_MDA_Timecourse_RSL3_n1_6h_RSL3_10uM_9 210309_MDA_Timecourse_RSL3_n1_24h_DMSO_10 210309_MDA_Timecourse_RSL3_n1_24h_RSL3_1uM_11 210309_MDA_Timecourse_RSL3_n1_24h_RSL3_10uM_12 210309_MDA_Timecourse_RSL3_n2_2h_DMSO_13 210309_MDA_Timecourse_RSL3_n2_2h_RSL3_1uM_14 210309_MDA_Timecourse_RSL3_n2_2h_RSL3_10uM_15 210309_MDA_Timecourse_RSL3_n2_4h_DMSO_16 210309_MDA_Timecourse_RSL3_n2_4h_RSL3_1uM_17 210309_MDA_Timecourse_RSL3_n2_4h_RSL3_10uM_18 210309_MDA_Timecourse_RSL3_n2_6h_DMSO_19 210309_MDA_Timecourse_RSL3_n2_6h_RSL3_1uM_20 210309_MDA_Timecourse_RSL3_n2_6h_RSL3_10uM_21 210309_MDA_Timecourse_RSL3_n2_24h_DMSO_22 210309_MDA_Timecourse_RSL3_n2_24h_RSL3_1uM_23 210309_MDA_Timecourse_RSL3_n2_24h_RSL3_10uM_24 210309_MDA_Timecourse_RSL3_n3_2h_DMSO_25 210309_MDA_Timecourse_RSL3_n3_2h_RSL3_1uM_26 210309_MDA_Timecourse_RSL3_n3_2h_RSL3_10uM_27 210309_MDA_Timecourse_RSL3_n3_4h_DMSO_28 210309_MDA_Timecourse_RSL3_n3_4h_RSL3_1uM_29 210309_MDA_Timecourse_RSL3_n3_4h_RSL3_10uM_30 210309_MDA_Timecourse_RSL3_n3_6h_DMSO_31 210309_MDA_Timecourse_RSL3_n3_6h_RSL3_1uM_32 210309_MDA_Timecourse_RSL3_n3_6h_RSL3_10uM_33 210309_MDA_Timecourse_RSL3_n3_24h_DMSO_34 210309_MDA_Timecourse_RSL3_n3_24h_RSL3_1uM_35 210309_MDA_Timecourse_RSL3_n3_24h_RSL3_10uM_36 210324_Rescue_Gust_compounds_2h_n1_DMSO_T41 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_T42 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_Ferrostatin1_3uM_T43 210324_Rescue_Gust_compounds_2h_n1_Ti41_1uM_T44 210324_Rescue_Gust_compounds_2h_n1_Ti41_3uM_T45 210324_Rescue_Gust_compounds_2h_n1_Ti41_10uM_T46 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_1uM_T47 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_3uM_T48 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_10uM_T49 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_1uM_T50 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_3uM_T51 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_10uM_T52 210324_Rescue_Gust_compounds_2h_n2_DMSO_T53 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_T54 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_Ferrostatin1_3uM_T55 210324_Rescue_Gust_compounds_2h_n2_Ti41_1uM_T56 210324_Rescue_Gust_compounds_2h_n2_Ti41_3uM_T57 210324_Rescue_Gust_compounds_2h_n2_Ti41_10uM_T58 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_1uM_T59 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_3uM_T60 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_10uM_T61 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_1uM_T62 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_3uM_T63 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_10uM_T64 210324_Rescue_Gust_compounds_2h_n3_DMSO_T65 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_T66 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_Ferrostatin1_3uM_T67 210324_Rescue_Gust_compounds_2h_n3_Ti41_1uM_T68 210324_Rescue_Gust_compounds_2h_n3_Ti41_3uM_T69 210324_Rescue_Gust_compounds_2h_n3_Ti41_10uM_T70 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_1uM_T71 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_3uM_T72 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_10uM_T73 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_1uM_T74 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_3uM_T75 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_10uM_T76 210309_MDA_Timecourse_RSL3_n1_2h_DMSO_1 210309_MDA_Timecourse_RSL3_n1_2h_RSL3_1uM_2 210309_MDA_Timecourse_RSL3_n1_2h_RSL3_10uM_3 210309_MDA_Timecourse_RSL3_n1_4h_DMSO_4 210309_MDA_Timecourse_RSL3_n1_4h_RSL3_1uM_5 210309_MDA_Timecourse_RSL3_n1_4h_RSL3_10uM_6 210309_MDA_Timecourse_RSL3_n1_6h_DMSO_7 210309_MDA_Timecourse_RSL3_n1_6h_RSL3_1uM_8 210309_MDA_Timecourse_RSL3_n1_6h_RSL3_10uM_9 210309_MDA_Timecourse_RSL3_n1_24h_DMSO_10 210309_MDA_Timecourse_RSL3_n1_24h_RSL3_1uM_11 210309_MDA_Timecourse_RSL3_n1_24h_RSL3_10uM_12 210309_MDA_Timecourse_RSL3_n2_2h_DMSO_13 210309_MDA_Timecourse_RSL3_n2_2h_RSL3_1uM_14 210309_MDA_Timecourse_RSL3_n2_2h_RSL3_10uM_15 210309_MDA_Timecourse_RSL3_n2_4h_DMSO_16 210309_MDA_Timecourse_RSL3_n2_4h_RSL3_1uM_17 210309_MDA_Timecourse_RSL3_n2_4h_RSL3_10uM_18 210309_MDA_Timecourse_RSL3_n2_6h_DMSO_19 210309_MDA_Timecourse_RSL3_n2_6h_RSL3_1uM_20 210309_MDA_Timecourse_RSL3_n2_6h_RSL3_10uM_21 210309_MDA_Timecourse_RSL3_n2_24h_DMSO_22 210309_MDA_Timecourse_RSL3_n2_24h_RSL3_1uM_23 210309_MDA_Timecourse_RSL3_n2_24h_RSL3_10uM_24 210309_MDA_Timecourse_RSL3_n3_2h_DMSO_25 210309_MDA_Timecourse_RSL3_n3_2h_RSL3_1uM_26 210309_MDA_Timecourse_RSL3_n3_2h_RSL3_10uM_27 210309_MDA_Timecourse_RSL3_n3_4h_DMSO_28 210309_MDA_Timecourse_RSL3_n3_4h_RSL3_1uM_29 210309_MDA_Timecourse_RSL3_n3_4h_RSL3_10uM_30 210309_MDA_Timecourse_RSL3_n3_6h_DMSO_31 210309_MDA_Timecourse_RSL3_n3_6h_RSL3_1uM_32 210309_MDA_Timecourse_RSL3_n3_6h_RSL3_10uM_33 210309_MDA_Timecourse_RSL3_n3_24h_DMSO_34 210309_MDA_Timecourse_RSL3_n3_24h_RSL3_1uM_35 210309_MDA_Timecourse_RSL3_n3_24h_RSL3_10uM_36 210324_Rescue_Gust_compounds_2h_n1_DMSO_T41 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_T42 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_Ferrostatin1_3uM_T43 210324_Rescue_Gust_compounds_2h_n1_Ti41_1uM_T44 210324_Rescue_Gust_compounds_2h_n1_Ti41_3uM_T45 210324_Rescue_Gust_compounds_2h_n1_Ti41_10uM_T46 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_1uM_T47 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_3uM_T48 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_10uM_T49 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_1uM_T50 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_3uM_T51 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_10uM_T52 210324_Rescue_Gust_compounds_2h_n2_DMSO_T53 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_T54 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_Ferrostatin1_3uM_T55 210324_Rescue_Gust_compounds_2h_n2_Ti41_1uM_T56 210324_Rescue_Gust_compounds_2h_n2_Ti41_3uM_T57 210324_Rescue_Gust_compounds_2h_n2_Ti41_10uM_T58 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_1uM_T59 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_3uM_T60 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_10uM_T61 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_1uM_T62 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_3uM_T63 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_10uM_T64 210324_Rescue_Gust_compounds_2h_n3_DMSO_T65 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_T66 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_Ferrostatin1_3uM_T67 210324_Rescue_Gust_compounds_2h_n3_Ti41_1uM_T68 210324_Rescue_Gust_compounds_2h_n3_Ti41_3uM_T69 210324_Rescue_Gust_compounds_2h_n3_Ti41_10uM_T70 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_1uM_T71 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_3uM_T72 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_10uM_T73 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_1uM_T74 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_3uM_T75 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_10uM_T76 210324_Rescue_Gust_compounds_2h_n1_DMSO_T41 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_T42 210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_Ferrostatin1_3uM_T43 210324_Rescue_Gust_compounds_2h_n1_Ti41_1uM_T44 210324_Rescue_Gust_compounds_2h_n1_Ti41_3uM_T45 210324_Rescue_Gust_compounds_2h_n1_Ti41_10uM_T46 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_1uM_T47 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_3uM_T48 210324_Rescue_Gust_compounds_2h_n1_Ti41_F_10uM_T49 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_1uM_T50 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_3uM_T51 210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_10uM_T52 210324_Rescue_Gust_compounds_2h_n2_DMSO_T53 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_T54 210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_Ferrostatin1_3uM_T55 210324_Rescue_Gust_compounds_2h_n2_Ti41_1uM_T56 210324_Rescue_Gust_compounds_2h_n2_Ti41_3uM_T57 210324_Rescue_Gust_compounds_2h_n2_Ti41_10uM_T58 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_1uM_T59 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_3uM_T60 210324_Rescue_Gust_compounds_2h_n2_Ti41_F_10uM_T61 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_1uM_T62 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_3uM_T63 210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_10uM_T64 210324_Rescue_Gust_compounds_2h_n3_DMSO_T65 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_T66 210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_Ferrostatin1_3uM_T67 210324_Rescue_Gust_compounds_2h_n3_Ti41_1uM_T68 210324_Rescue_Gust_compounds_2h_n3_Ti41_3uM_T69 210324_Rescue_Gust_compounds_2h_n3_Ti41_10uM_T70 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_1uM_T71 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_3uM_T72 210324_Rescue_Gust_compounds_2h_n3_Ti41_F_10uM_T73 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_1uM_T74 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_3uM_T75 210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_10uM_T76 Factors Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:4 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:4 h Sample source:Breast cancer cells | Treatment:DMSO | time point:6 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:6 h Sample source:Breast cancer cells | Treatment:DMSO | time point:24 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:10 µM RSL3 | time point:24 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:DMSO | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM RSL3 + 3 µM Ferrostatin | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 1 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 2 | time point:2 h Sample source:Breast cancer cells | Treatment:1 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:3 µM Comp. 3 | time point:2 h Sample source:Breast cancer cells | Treatment:10 µM Comp. 3 | time point:2 h PE 16:0/20:4;O 6.38E-05 1.67E-04 1.49E-04 6.45E-05 2.44E-04 1.50E-04 6.32E-05 1.22E-04 9.73E-05 4.36E-05 8.68E-05 5.03E-05 6.30E-05 2.38E-04 1.74E-04 6.22E-05 1.95E-04 1.32E-04 7.40E-05 1.30E-04 1.08E-04 4.28E-05 7.17E-05 4.50E-05 6.27E-05 2.98E-04 2.48E-04 8.01E-05 2.38E-04 1.92E-04 5.89E-05 1.90E-04 1.21E-04 5.46E-05 9.07E-05 5.16E-05 4.68369E-05 0.000263402 5.30904E-05 0.000315276 0.000429787 0.000608209 0.000293044 0.000420379 0.000412253 0.000633477 0.000468493 0.000438708 6.83063E-05 0.000228864 4.63909E-05 0.000283265 0.000524242 0.000444447 0.000242377 0.000513878 0.000497918 0.000410093 0.000363607 0.000316797 5.2519E-05 0.000197611 3.52296E-05 0.000285875 0.000324852 0.000378214 0.000245408 0.000378896 0.000451631 0.000201246 0.000382698 0.000360362 PE 16:0/20:4;O2 5.81E-05 6.83E-05 6.92E-05 7.02E-05 7.92E-05 6.17E-05 4.88E-05 6.54E-05 3.93E-05 2.93E-05 5.50E-05 6.26E-05 5.57E-05 6.90E-05 7.94E-05 3.46E-05 8.17E-05 7.30E-05 5.24E-05 6.68E-05 6.86E-05 4.43E-05 5.24E-05 7.41E-05 6.48E-05 8.87E-05 8.38E-05 5.29E-05 1.04E-04 7.00E-05 5.42E-05 8.80E-05 3.74E-05 4.65E-05 5.96E-05 5.63E-05 PE 16:0/20:4;O3 2.90E-05 2.09E-04 2.16E-04 1.96E-05 2.14E-04 1.09E-04 1.43E-05 1.09E-04 6.43E-05 2.37E-05 5.29E-05 1.01E-05 1.21E-05 2.26E-04 2.09E-04 2.18E-05 1.89E-04 1.42E-04 1.34E-05 1.01E-04 8.17E-05 1.43E-05 2.01E-05 1.40E-05 8.36E-06 2.43E-04 2.59E-04 1.27E-05 1.47E-04 1.41E-04 1.70E-05 1.25E-04 7.17E-05 1.50E-05 2.03E-05 4.68E-06 PE 18:0/20:4;O 2.78E-03 3.64E-03 5.24E-03 2.31E-03 5.30E-03 3.29E-03 2.52E-03 3.55E-03 3.14E-03 1.95E-03 2.79E-03 1.71E-03 2.35E-03 5.00E-03 3.94E-03 1.77E-03 3.81E-03 3.76E-03 2.12E-03 3.29E-03 3.00E-03 1.81E-03 2.07E-03 1.55E-03 2.46E-03 6.03E-03 6.55E-03 2.76E-03 5.10E-03 4.09E-03 2.49E-03 5.10E-03 2.90E-03 2.51E-03 2.47E-03 1.18E-03 0.002646686 0.005628262 0.002499662 0.006834778 0.006858022 0.009551341 0.005546085 0.005767176 0.006638312 0.011052814 0.00839238 0.008483326 0.002360321 0.005246848 0.001751733 0.005506578 0.008703996 0.008096838 0.005342867 0.008390143 0.009743523 0.007155243 0.006513489 0.006125927 0.001437488 0.004028815 0.001407703 0.005510676 0.004860741 0.005360986 0.004226242 0.005195751 0.006667216 0.003627547 0.005731283 0.006332477 PE 18:0/20:4;O2 4.91E-04 8.99E-04 1.13E-03 4.18E-04 1.17E-03 8.60E-04 4.63E-04 7.73E-04 6.74E-04 3.75E-04 5.90E-04 3.79E-04 4.43E-04 1.07E-03 8.24E-04 3.80E-04 9.15E-04 8.35E-04 4.58E-04 7.27E-04 6.52E-04 3.43E-04 3.76E-04 2.71E-04 6.08E-04 1.24E-03 1.41E-03 3.72E-04 1.07E-03 9.72E-04 3.73E-04 1.01E-03 6.30E-04 4.18E-04 4.88E-04 2.95E-04 0.000178127 0.000421093 0.000145276 0.000809216 0.000848183 0.001500601 0.000631397 0.000993962 0.000956287 0.001439689 0.001288036 0.001329814 0.000169998 0.000435816 9.06279E-05 0.000692338 0.001275292 0.001359607 0.000672786 0.001409002 0.001634632 0.000932009 0.00099967 0.000960277 0.00011165 0.000338439 8.75916E-05 0.00066999 0.000658123 0.000778059 0.000518693 0.000722081 0.001029331 0.000376705 0.000702302 0.000770036 PE 18:0/20:4;O3 3.50E-04 1.46E-03 1.93E-03 2.35E-04 1.52E-03 1.15E-03 2.69E-04 8.89E-04 6.35E-04 2.16E-04 4.29E-04 1.65E-04 2.06E-04 1.63E-03 1.34E-03 2.26E-04 1.15E-03 9.63E-04 1.93E-04 8.35E-04 6.51E-04 1.72E-04 2.08E-04 1.45E-04 1.99E-04 1.55E-03 1.93E-03 1.77E-04 1.28E-03 1.07E-03 1.47E-04 9.70E-04 6.26E-04 1.35E-04 3.16E-04 9.06E-05 8.43787E-05 0.000854909 4.20316E-05 0.00200752 0.001796124 0.002780037 0.001678363 0.001389564 0.001834744 0.001845397 0.001635734 0.002149114 6.75829E-05 0.000820055 2.75568E-05 0.00123493 0.002091979 0.002535704 0.000945 0.002012671 0.002444617 0.001194652 0.001269525 0.001551905 3.28222E-05 0.000628073 3.06895E-05 0.001214651 0.000962058 0.0015448 0.000794506 0.001068373 0.001660364 0.000765171 0.00110661 0.001402478 PE 18:1/20:4;O 7.72E-04 1.29E-03 1.53E-03 9.25E-04 1.47E-03 1.19E-03 9.49E-04 1.05E-03 9.61E-04 5.90E-04 8.60E-04 4.90E-04 8.85E-04 1.73E-03 1.33E-03 9.00E-04 1.28E-03 1.32E-03 9.81E-04 1.10E-03 1.04E-03 6.14E-04 5.92E-04 4.53E-04 1.18E-03 2.27E-03 2.43E-03 1.05E-03 1.80E-03 1.43E-03 8.45E-04 1.61E-03 8.89E-04 8.00E-04 8.98E-04 3.63E-04 0.000363803 0.001354142 0.000351899 0.00180224 0.001892215 0.002615649 0.001514248 0.001853477 0.001880446 0.00313419 0.002392245 0.002703855 0.0004836 0.001433614 0.000303283 0.001570946 0.002464498 0.002136841 0.001520808 0.002407582 0.002602862 0.002028976 0.001856668 0.001952491 0.000317288 0.001174656 0.000245523 0.001673024 0.00140913 0.001580957 0.001340598 0.00155162 0.00208947 0.001065071 0.001782161 0.001942291 PE 18:1/20:4;O2 2.49E-04 4.28E-04 3.59E-04 2.10E-04 4.32E-04 2.05E-04 2.27E-04 2.37E-04 1.92E-04 2.10E-04 2.17E-04 1.22E-04 1.84E-04 4.40E-04 3.47E-04 1.30E-04 2.64E-04 2.94E-04 1.77E-04 1.80E-04 2.27E-04 1.64E-04 1.38E-04 1.25E-04 1.67E-04 4.06E-04 5.17E-04 2.39E-04 2.88E-04 3.22E-04 1.56E-04 2.97E-04 1.67E-04 1.74E-04 1.74E-04 1.06E-04 4.47785E-05 0.000174686 2.90577E-05 0.000240035 0.000342825 0.000544624 0.00018293 0.000295873 0.000346884 0.000378531 0.000319245 0.000440021 6.01814E-05 0.000163508 2.75275E-05 0.000204137 0.000431433 0.000389162 0.000176154 0.000404211 0.000474833 0.000245049 0.000247772 0.000317746 3.60994E-05 0.000129768 3.06965E-05 0.000197066 0.000211625 0.000234533 0.000167531 0.000255101 0.000331015 9.67672E-05 0.000211937 0.00028716 PE 18:1/20:4;O3 2.80E-04 8.07E-04 1.04E-03 1.84E-04 7.08E-04 5.35E-04 2.05E-04 4.11E-04 3.41E-04 2.22E-04 3.11E-04 1.41E-04 1.55E-04 8.74E-04 8.07E-04 1.46E-04 6.26E-04 6.46E-04 2.47E-04 4.19E-04 4.16E-04 1.95E-04 1.58E-04 1.43E-04 1.78E-04 9.79E-04 1.11E-03 1.92E-04 7.54E-04 6.52E-04 1.63E-04 5.90E-04 3.34E-04 1.50E-04 2.05E-04 7.98E-05 3.5393E-05 0.000401496 1.69871E-05 0.001022686 0.001034534 0.001850294 0.000807467 0.000885617 0.001204112 0.00108367 0.000983629 0.001462503 4.00072E-05 0.000370157 1.25821E-05 0.000608514 0.001266658 0.001507021 0.00051268 0.001263148 0.001680271 0.000701533 0.000763414 0.001056094 2.40866E-05 0.000271789 1.36417E-05 0.000605734 0.000548196 0.000841013 0.000412109 0.000548105 0.001204574 0.000295992 0.000582869 0.000790305 PE 16:0/22:4;O 2.90E-05 6.32E-05 6.46E-05 5.05E-05 7.41E-05 4.60E-05 4.18E-05 4.21E-05 2.90E-05 2.30E-05 2.96E-05 1.46E-05 4.00E-05 7.82E-05 6.12E-05 4.04E-05 6.40E-05 6.74E-05 3.41E-05 6.06E-05 3.38E-05 2.00E-05 1.84E-05 1.29E-05 5.23E-05 1.24E-04 1.50E-04 5.11E-05 1.00E-04 1.25E-04 4.49E-05 7.15E-05 6.81E-05 1.92E-05 3.22E-05 1.87E-05 0.000279531 0.000968765 0.000186116 0.001251606 0.001240345 0.001874736 0.000979476 0.001256574 0.001159239 0.001968152 0.001633603 0.00144753 0.000242456 0.000857992 0.000139068 0.00098539 0.00159178 0.001275865 0.0009393 0.001624611 0.001693066 0.001274119 0.001267871 0.001045281 0.000200234 0.000835668 0.000113755 0.001199549 0.001128533 0.000934864 0.00091443 0.001139239 0.00122996 0.000685509 0.001299187 0.001082902 PE 16:0/22:4;O2* 3.91E-05 6.05E-05 5.43E-05 2.67E-05 6.66E-05 4.71E-05 2.86E-05 5.62E-05 4.76E-05 1.98E-05 4.66E-05 2.92E-05 4.85E-05 7.59E-05 4.40E-05 1.58E-05 4.40E-05 4.35E-05 3.08E-05 5.81E-05 4.20E-05 1.71E-05 1.84E-05 2.15E-05 2.72E-05 8.37E-05 6.99E-05 3.28E-05 6.81E-05 4.72E-05 2.94E-05 6.60E-05 4.42E-05 2.33E-05 2.98E-05 4.54E-05 PE 16:0/22:4;O3* 1.56E-05 1.06E-04 1.46E-04 1.83E-05 1.38E-04 7.97E-05 2.02E-05 6.63E-05 4.77E-05 1.58E-05 4.65E-05 3.93E-05 1.21E-05 9.32E-05 1.20E-04 8.92E-06 1.21E-04 9.98E-05 9.25E-06 7.36E-05 6.25E-05 1.43E-05 1.40E-05 9.66E-06 2.09E-05 1.44E-04 1.89E-04 1.46E-05 1.02E-04 1.06E-04 1.24E-05 1.23E-04 6.12E-05 2.19E-05 4.89E-05 1.87E-05 PE 18:0/22:4;O 6.75E-04 6.59E-04 8.71E-04 5.49E-04 9.90E-04 4.86E-04 5.25E-04 6.81E-04 4.45E-04 5.69E-04 4.56E-04 2.90E-04 5.28E-04 9.53E-04 5.62E-04 3.74E-04 6.85E-04 5.63E-04 4.59E-04 5.33E-04 3.93E-04 5.86E-04 4.63E-04 2.30E-04 5.04E-04 9.61E-04 9.38E-04 6.93E-04 8.76E-04 5.81E-04 5.61E-04 7.86E-04 4.69E-04 6.20E-04 4.40E-04 1.78E-04 PE 18:0/22:4;O2* 3.57E-05 7.60E-05 1.15E-04 1.26E-05 1.40E-04 1.10E-04 2.26E-05 9.91E-05 6.51E-05 1.50E-05 5.38E-05 2.02E-05 2.31E-05 1.19E-04 8.05E-05 7.89E-06 1.03E-04 7.74E-05 2.06E-05 7.89E-05 5.93E-05 1.00E-05 3.41E-05 1.83E-05 1.25E-05 1.39E-04 1.68E-04 7.31E-06 1.39E-04 9.77E-05 1.55E-05 1.06E-04 9.71E-05 1.23E-05 5.48E-05 3.75E-05 1.14535E-05 3.64396E-05 5.01883E-06 5.43098E-05 5.34229E-05 0.000128266 4.52419E-05 7.73874E-05 5.8228E-05 0.000118776 0.000100994 9.66307E-05 1.08427E-05 1.7473E-05 7.06584E-06 5.30656E-05 0.000103547 6.7236E-05 5.89207E-05 0.000110019 0.000102927 7.68917E-05 7.83835E-05 6.97784E-05 1.5334E-05 2.51429E-05 1.2504E-05 3.20231E-05 6.81585E-05 6.39668E-05 5.94065E-05 9.22091E-05 6.87012E-05 2.84672E-05 6.91035E-05 4.88912E-05 PE 18:0/22:4;O3* 3.80E-05 2.15E-04 2.71E-04 4.63E-05 2.94E-04 1.92E-04 1.79E-05 1.61E-04 1.09E-04 3.64E-05 7.51E-05 3.14E-05 4.00E-05 2.83E-04 2.01E-04 3.56E-05 2.41E-04 1.55E-04 4.01E-05 1.45E-04 1.21E-04 4.64E-05 4.46E-05 2.26E-05 3.13E-05 2.46E-04 3.02E-04 2.92E-05 2.80E-04 2.15E-04 2.48E-05 1.87E-04 1.12E-04 3.42E-05 7.16E-05 1.88E-05 2.08422E-06 8.66676E-05 -3.00137E-06 0.00013398 0.000132387 0.000165284 0.000128085 7.53777E-05 0.00012541 0.00013258 0.000121382 9.67108E-05 8.29286E-07 5.66926E-05 0 6.87013E-05 0.000139943 0.000131757 6.38753E-05 8.74101E-05 9.48933E-05 8.58284E-05 9.42069E-05 6.98362E-05 0 6.93866E-05 3.39898E-06 0.000112637 6.93642E-05 9.35737E-05 6.90433E-05 0.000101774 0.000114907 8.31686E-05 9.56821E-05 9.81069E-05 PC 16:0/20:4;O 1.52E-04 2.28E-04 2.73E-04 1.71E-04 3.05E-04 1.79E-04 1.56E-04 2.27E-04 2.09E-04 1.04E-04 1.32E-04 1.32E-04 1.23E-04 2.49E-04 1.31E-04 1.48E-04 2.14E-04 1.27E-04 1.52E-04 1.72E-04 1.36E-04 8.84E-05 9.82E-05 7.66E-05 2.02E-04 2.51E-04 2.67E-04 1.53E-04 2.46E-04 1.80E-04 1.82E-04 1.98E-04 1.44E-04 1.20E-04 1.26E-04 5.95E-05 1.52E-04 1.75E-04 1.12E-04 4.23E-04 4.08E-04 5.31E-04 3.39E-04 4.30E-04 5.05E-04 5.95E-04 4.46E-04 4.82E-04 1.10E-04 2.10E-04 8.79E-05 3.57E-04 4.63E-04 4.61E-04 2.58E-04 4.14E-04 4.22E-04 3.85E-04 3.46E-04 3.48E-04 1.07E-04 2.01E-04 1.06E-04 4.61E-04 4.35E-04 4.58E-04 3.66E-04 4.53E-04 6.17E-04 3.19E-04 4.41E-04 5.61E-04 PC 16:0/20:4;O2 2.36E-04 2.50E-04 1.47E-04 2.27E-04 2.52E-04 1.28E-04 2.25E-04 2.13E-04 1.64E-04 8.33E-05 1.15E-04 1.28E-04 2.15E-04 2.50E-04 8.03E-05 2.12E-04 1.64E-04 8.11E-05 2.23E-04 1.89E-04 7.10E-05 8.47E-05 1.20E-04 8.31E-05 1.51E-04 1.96E-04 1.45E-04 1.70E-04 1.68E-04 1.45E-04 1.35E-04 2.13E-04 1.05E-04 6.52E-05 1.06E-04 1.09E-04 6.78E-05 8.21E-05 6.76E-05 2.14E-04 2.23E-04 3.87E-04 1.60E-04 2.72E-04 2.44E-04 3.35E-04 3.12E-04 3.07E-04 6.73E-05 7.79E-05 3.46E-05 1.68E-04 2.68E-04 2.28E-04 1.74E-04 3.67E-04 2.60E-04 2.17E-04 2.42E-04 2.22E-04 8.05E-05 9.81E-05 8.51E-05 1.85E-04 2.59E-04 2.16E-04 2.05E-04 2.93E-04 3.33E-04 1.03E-04 3.11E-04 2.65E-04 PC 16:0/20:4;O3 1.69E-04 1.57E-04 1.34E-04 1.17E-04 1.14E-04 5.88E-05 1.39E-04 9.98E-05 8.58E-05 1.10E-04 1.19E-04 1.32E-04 1.12E-04 1.33E-04 1.46E-04 7.34E-05 9.27E-05 1.62E-04 7.76E-05 6.08E-05 1.23E-04 4.95E-05 7.76E-05 1.12E-04 1.28E-04 1.35E-04 1.50E-04 1.63E-04 1.20E-04 1.40E-04 1.14E-04 1.31E-04 7.31E-05 6.85E-05 9.58E-05 7.57E-05 6.70E-06 2.74E-05 1.47E-06 2.33E-04 2.28E-04 2.39E-04 2.04E-04 1.64E-04 2.52E-04 2.29E-04 2.02E-04 2.20E-04 5.09E-06 4.05E-05 5.41E-07 1.27E-04 2.07E-04 2.43E-04 1.18E-04 1.83E-04 2.22E-04 1.48E-04 1.57E-04 1.59E-04 9.25E-07 2.21E-05 3.15E-06 2.32E-04 1.84E-04 2.27E-04 1.52E-04 1.81E-04 2.64E-04 1.41E-04 2.16E-04 2.61E-04 PC 18:0/20:4;O 1.38E-04 2.15E-04 2.95E-04 1.78E-04 3.29E-04 2.61E-04 1.66E-04 1.98E-04 2.59E-04 1.26E-04 1.72E-04 1.35E-04 1.26E-04 2.24E-04 1.87E-04 1.01E-04 2.32E-04 1.59E-04 1.25E-04 1.98E-04 1.56E-04 1.06E-04 1.29E-04 1.14E-04 1.58E-04 2.69E-04 2.87E-04 1.37E-04 2.58E-04 2.14E-04 1.52E-04 2.58E-04 1.82E-04 1.71E-04 1.35E-04 1.25E-04 2.06E-04 3.30E-04 2.06E-04 6.46E-04 5.98E-04 7.60E-04 5.89E-04 5.27E-04 6.48E-04 6.50E-04 6.61E-04 6.89E-04 1.64E-04 3.51E-04 1.23E-04 4.47E-04 6.04E-04 5.89E-04 3.90E-04 6.19E-04 5.68E-04 4.21E-04 5.13E-04 4.98E-04 1.24E-04 2.96E-04 8.60E-05 6.82E-04 6.27E-04 6.46E-04 4.77E-04 5.72E-04 7.92E-04 4.86E-04 6.09E-04 7.69E-04 PC 18:0/20:4;O2 4.96E-05 4.19E-05 5.04E-05 4.08E-05 5.00E-05 5.50E-05 4.34E-05 3.97E-05 4.02E-05 2.39E-05 3.75E-05 2.95E-05 3.80E-05 5.16E-05 3.09E-05 4.19E-05 2.16E-05 4.10E-05 3.18E-05 2.76E-05 4.10E-05 2.10E-05 1.81E-05 2.04E-05 3.55E-05 3.99E-05 3.38E-05 4.20E-05 2.45E-05 4.03E-05 3.52E-05 3.87E-05 1.43E-05 1.98E-05 4.05E-05 4.10E-05 1.76E-05 2.24E-05 2.06E-05 1.18E-04 1.38E-04 2.18E-04 9.13E-05 1.16E-04 2.13E-04 1.32E-04 1.16E-04 1.50E-04 1.90E-05 3.06E-05 8.68E-06 7.69E-05 1.14E-04 1.62E-04 8.32E-05 1.47E-04 1.51E-04 8.54E-05 9.03E-05 1.08E-04 1.30E-05 2.65E-05 7.34E-06 7.96E-05 1.06E-04 1.25E-04 8.82E-05 9.54E-05 1.56E-04 4.94E-05 1.16E-04 1.68E-04 PC 18:0/20:4;O3 4.96E-05 7.06E-05 3.93E-05 7.32E-05 6.21E-05 6.01E-05 5.98E-05 4.81E-05 6.37E-05 3.10E-05 5.33E-05 7.33E-05 6.28E-05 5.03E-05 3.70E-05 5.34E-05 4.84E-05 3.22E-05 5.91E-05 4.87E-05 4.51E-05 2.89E-05 4.45E-05 8.42E-05 5.50E-05 6.15E-05 6.95E-05 6.16E-05 6.46E-05 5.60E-05 8.56E-05 7.74E-05 6.95E-05 3.88E-05 6.26E-05 9.02E-05 5.02E-06 1.99E-05 1.47E-06 2.49E-04 1.97E-04 2.40E-04 2.52E-04 1.41E-04 2.34E-04 2.21E-04 1.95E-04 1.79E-04 5.08E-06 3.44E-05 0.00E+00 1.47E-04 2.03E-04 2.00E-04 9.03E-05 1.90E-04 1.80E-04 1.43E-04 1.51E-04 1.29E-04 1.85E-06 2.32E-05 0.00E+00 2.27E-04 1.57E-04 1.40E-04 1.52E-04 1.62E-04 2.52E-04 1.17E-04 2.03E-04 2.37E-04 PC 18:1/20:4;O 1.39E-04 2.24E-04 2.39E-04 1.44E-04 3.13E-04 2.21E-04 1.36E-04 2.01E-04 2.08E-04 8.48E-05 1.67E-04 1.07E-04 1.23E-04 2.40E-04 1.96E-04 1.01E-04 2.29E-04 1.58E-04 1.41E-04 1.76E-04 1.43E-04 5.41E-05 1.02E-04 6.39E-05 1.76E-04 2.59E-04 2.77E-04 1.59E-04 2.43E-04 2.40E-04 1.65E-04 2.60E-04 1.50E-04 1.02E-04 1.66E-04 1.00E-04 2.44E-04 3.53E-04 1.99E-04 6.37E-04 5.64E-04 6.70E-04 5.97E-04 5.59E-04 6.42E-04 8.31E-04 7.01E-04 6.76E-04 1.98E-04 3.52E-04 1.54E-04 4.96E-04 6.60E-04 6.43E-04 4.23E-04 6.03E-04 5.93E-04 5.38E-04 5.44E-04 4.88E-04 1.35E-04 3.17E-04 1.17E-04 7.75E-04 6.43E-04 6.18E-04 5.51E-04 5.83E-04 8.79E-04 5.17E-04 7.65E-04 7.37E-04 PC 18:1/20:4;O2 5.51E-05 7.77E-05 6.16E-05 5.03E-05 4.32E-05 6.65E-05 5.04E-05 3.85E-05 5.54E-05 1.95E-05 2.44E-05 3.52E-05 5.60E-05 5.92E-05 3.17E-05 5.87E-05 2.67E-05 2.54E-05 6.27E-05 4.87E-05 4.60E-05 1.27E-05 1.07E-05 2.04E-05 6.75E-05 7.65E-05 7.48E-05 5.55E-05 4.37E-05 5.25E-05 4.48E-05 4.95E-05 2.67E-05 1.38E-05 2.21E-05 2.46E-05 1.67E-05 4.23E-05 8.08E-06 3.07E-04 3.05E-04 4.68E-04 2.87E-04 4.23E-04 3.29E-04 5.27E-04 4.90E-04 4.08E-04 2.60E-05 6.34E-05 1.03E-05 2.81E-04 4.30E-04 3.07E-04 2.74E-04 4.69E-04 3.85E-04 3.41E-04 3.81E-04 2.95E-04 2.41E-05 5.96E-05 5.24E-06 2.38E-04 3.22E-04 2.53E-04 3.20E-04 4.20E-04 4.77E-04 1.33E-04 3.83E-04 2.64E-04 PC 18:1/20:4;O3 1.16E-04 1.08E-04 7.02E-05 7.72E-05 1.45E-04 4.72E-05 1.09E-04 9.84E-05 7.74E-05 4.50E-05 8.73E-05 7.33E-05 8.04E-05 8.80E-05 8.46E-05 7.22E-05 7.11E-05 1.01E-04 9.85E-05 9.17E-05 9.21E-05 5.41E-05 8.08E-05 1.33E-04 1.21E-04 1.05E-04 9.98E-05 1.16E-04 1.03E-04 1.12E-04 8.70E-05 1.51E-04 8.73E-05 7.52E-05 1.21E-04 1.02E-04 1.68E-06 1.74E-05 3.68E-06 2.11E-04 1.81E-04 2.18E-04 1.61E-04 1.32E-04 1.76E-04 1.73E-04 1.65E-04 2.10E-04 4.45E-06 2.60E-05 5.41E-07 1.35E-04 1.58E-04 2.02E-04 7.96E-05 1.39E-04 1.57E-04 1.12E-04 1.28E-04 1.52E-04 9.22E-07 2.87E-05 5.24E-06 2.08E-04 1.42E-04 2.02E-04 1.37E-04 1.09E-04 2.34E-04 9.35E-05 1.68E-04 2.28E-04 PC 16:0/22:4;O 9.82E-05 1.21E-04 8.88E-05 1.11E-04 1.40E-04 9.61E-05 8.81E-05 1.19E-04 1.45E-04 5.41E-05 9.96E-05 1.25E-04 1.10E-04 1.17E-04 7.67E-05 7.76E-05 9.47E-05 9.87E-05 7.68E-05 6.97E-05 9.21E-05 4.10E-05 7.36E-05 7.02E-05 7.11E-05 9.14E-05 1.39E-04 1.12E-04 1.03E-04 1.16E-04 1.00E-04 9.03E-05 1.25E-04 5.40E-05 6.87E-05 1.33E-04 2.90E-04 3.33E-04 2.97E-04 2.67E-04 2.60E-04 3.75E-04 1.89E-04 2.31E-04 3.22E-04 4.61E-04 3.81E-04 3.82E-04 2.65E-04 3.02E-04 2.05E-04 2.15E-04 2.55E-04 3.07E-04 2.20E-04 3.09E-04 3.71E-04 2.98E-04 2.96E-04 2.76E-04 3.13E-04 2.66E-04 2.82E-04 2.45E-04 2.25E-04 2.59E-04 2.10E-04 2.35E-04 3.47E-04 2.55E-04 3.26E-04 3.55E-04 PC 16:0/22:4;O2* 2.51E-06 3.31E-06 2.94E-06 4.30E-05 4.68E-05 5.96E-05 2.36E-05 5.83E-05 4.66E-05 4.29E-05 5.03E-05 4.38E-05 1.27E-06 4.58E-06 2.71E-06 1.74E-05 5.68E-05 6.29E-05 2.42E-05 6.52E-05 5.03E-05 2.78E-05 3.90E-05 3.16E-05 3.70E-06 6.63E-06 2.10E-06 3.54E-05 6.00E-05 5.17E-05 3.88E-05 5.14E-05 8.76E-05 8.42E-06 4.50E-05 5.64E-05 PC 16:0/22:4;O3* 0.00E+00 0.00E+00 0.00E+00 4.13E-06 3.46E-06 2.98E-06 5.06E-06 0.00E+00 5.29E-06 0.00E+00 9.88E-07 2.97E-06 0.00E+00 0.00E+00 0.00E+00 1.75E-06 2.43E-06 5.58E-06 1.03E-06 4.16E-06 6.29E-06 0.00E+00 7.66E-07 2.15E-06 0.00E+00 1.10E-06 0.00E+00 6.64E-06 2.00E-06 6.58E-06 2.42E-06 7.50E-06 1.11E-05 2.10E-06 6.12E-06 5.23E-06 PC 18:0/22:4;O 1.86E-04 1.86E-04 1.38E-04 1.67E-04 2.24E-04 1.34E-04 1.66E-04 1.32E-04 1.54E-04 6.78E-05 1.25E-04 1.01E-04 1.91E-04 1.79E-04 1.27E-04 1.66E-04 1.41E-04 1.36E-04 1.56E-04 1.14E-04 8.70E-05 5.47E-05 1.01E-04 1.11E-04 2.45E-04 2.83E-04 2.23E-04 2.50E-04 1.76E-04 1.98E-04 1.86E-04 1.98E-04 1.09E-04 7.77E-05 1.03E-04 6.96E-05 1.07E-03 1.03E-03 1.21E-03 5.38E-04 5.84E-04 5.33E-04 4.67E-04 3.55E-04 5.46E-04 1.14E-03 8.58E-04 8.10E-04 9.64E-04 9.18E-04 7.53E-04 5.77E-04 6.96E-04 5.65E-04 5.57E-04 6.14E-04 7.12E-04 7.41E-04 6.66E-04 5.85E-04 6.82E-04 7.02E-04 7.81E-04 4.62E-04 3.18E-04 3.02E-04 3.51E-04 2.88E-04 3.25E-04 4.55E-04 4.76E-04 3.86E-04 PC 18:0/22:4;O3* 0.00E+00 8.30E-07 0.00E+00 5.80E-06 8.64E-06 1.99E-05 3.37E-06 5.48E-06 9.72E-06 1.51E-05 2.27E-05 1.59E-05 0.00E+00 7.65E-07 0.00E+00 8.14E-06 1.13E-05 7.16E-06 9.76E-06 2.08E-05 1.97E-05 9.75E-06 1.76E-05 1.15E-05 0.00E+00 2.21E-06 0.00E+00 1.11E-05 6.01E-06 1.03E-05 8.09E-06 1.07E-06 7.41E-06 1.05E-06 8.57E-06 6.55E-06 PI 16:0/20:4;O 9.35285E-06 2.67815E-05 1.37074E-05 5.74085E-05 9.75855E-05 0.000188095 5.5094E-05 7.03147E-05 0.000131726 9.88622E-05 9.26646E-05 0.000154341 6.20451E-06 3.49512E-05 7.19453E-06 5.06755E-05 0.000106314 0.000180925 5.60176E-05 0.000116363 0.000156029 6.40003E-05 7.19188E-05 0.000111452 1.15026E-05 3.31066E-05 2.44587E-06 4.81105E-05 6.0283E-05 7.13416E-05 5.08074E-05 4.20993E-05 0.000106639 4.85452E-05 7.46023E-05 8.85542E-05 PI 16:0/20:4;O3 2.27278E-05 2.58255E-05 3.05713E-05 0.000103825 0.000108114 0.000208146 7.64991E-05 0.000115384 0.000203572 0.000160922 0.000132104 0.00021396 2.86747E-05 5.87952E-05 2.74086E-05 6.67296E-05 0.000139117 0.000246888 6.92962E-05 0.000148222 0.000234041 0.000104176 0.000102528 0.000154503 2.72434E-05 6.00085E-05 2.84008E-05 8.52976E-05 7.59454E-05 0.000133573 5.0835E-05 7.4679E-05 0.000164716 4.39339E-05 0.000101193 0.000164621 PI 18:0/20:4;O 0.000447569 0.001071242 0.000456072 0.002349426 0.00289889 0.004297865 0.001809245 0.002003894 0.004150231 0.003889293 0.003437789 0.004192704 0.000415385 0.001444635 0.000295534 0.001933025 0.003312576 0.004113436 0.001933232 0.003269904 0.004121781 0.002517805 0.002668135 0.003027609 0.000242912 0.001021508 0.000241748 0.001939197 0.00190818 0.002010951 0.001553102 0.001893787 0.003098589 0.001247376 0.002203082 0.002507443 PI 18:0/20:4;O2 3.73892E-05 0.000133042 3.69018E-05 0.00068368 0.000823799 0.001650329 0.000584626 0.000706375 0.001274768 0.001009682 0.000958574 0.001325472 4.7941E-05 0.00019148 3.16966E-05 0.000477887 0.001033825 0.001482957 0.000527197 0.001195034 0.001469803 0.000653636 0.000743968 0.000957142 1.99006E-05 0.000137084 3.20559E-05 0.000544586 0.000577229 0.000737126 0.000471463 0.000716548 0.001100545 0.000308908 0.000721363 0.000850396 PI 18:0/20:4;O3 4.14224E-05 0.000510028 3.89537E-05 0.003447475 0.003802175 0.006232372 0.002533572 0.002371049 0.005072343 0.00367715 0.003632333 0.005008677 9.13854E-05 0.000882664 4.5362E-05 0.001738516 0.00342062 0.005555747 0.00175007 0.004225211 0.004886301 0.002380471 0.002819124 0.003616834 5.44404E-05 0.00062623 2.96442E-05 0.002427232 0.002273776 0.002910174 0.001760304 0.002553298 0.004476509 0.001138292 0.002752015 0.003531561 PI 18:1/20:4;O 3.88162E-05 5.94446E-05 2.93705E-05 0.000222209 0.000331127 0.000509529 0.00016359 0.000267076 0.000464664 0.000414531 0.000353085 0.000542524 2.08886E-05 9.56867E-05 1.4407E-05 0.000180888 0.000365688 0.000512414 0.000191589 0.000440241 0.000543989 0.000268354 0.000274036 0.000391764 1.36159E-05 7.47655E-05 2.10085E-05 0.000163336 0.000198411 0.000248669 0.00014996 0.000224197 0.000420931 0.000130812 0.00022543 0.000359728 PI 18:1/20:4;O2 2.66907E-06 5.95847E-06 2.10435E-06 5.75678E-05 0.000140263 0.000272561 6.43993E-05 0.000109167 0.000185239 0.000148512 0.000178261 0.000229249 5.41905E-06 2.39382E-05 2.15298E-06 6.19907E-05 0.000142565 0.000230373 7.12747E-05 0.000185223 0.000249032 9.61418E-05 0.000138352 0.000165544 1.04938E-06 2.21186E-05 0 7.92025E-05 7.2848E-05 0.000124206 6.16774E-05 0.000139872 0.000208259 5.94244E-05 8.93605E-05 0.000131339 PI 18:1/20:4;O3 4.13817E-05 9.4451E-05 2.21131E-05 0.000836526 0.001116181 0.002362318 0.000703245 0.00091209 0.002033899 0.001111435 0.001194675 0.00204518 3.94037E-05 0.000176742 1.44209E-05 0.000518965 0.001221852 0.002206373 0.000485318 0.001628664 0.001900175 0.000719508 0.000927211 0.001476852 1.57118E-05 0.000122415 1.2366E-06 0.000660702 0.000735023 0.001156451 0.000525345 0.00076836 0.001786803 0.000259873 0.000851939 0.001408628 PI 18:0/22:4;O 9.47115E-05 0.000182433 7.70039E-05 0.000278899 0.000349813 0.000495804 0.000233285 0.000229303 0.000456683 0.000460733 0.000422137 0.000435273 6.27171E-05 0.000237368 6.54983E-05 0.000244191 0.000387031 0.00048041 0.000243016 0.000429546 0.000497561 0.000298264 0.000327629 0.000314317 6.07019E-05 0.000187845 5.67606E-05 0.000232745 0.000208112 0.000244769 0.000175208 0.000245674 0.00033177 0.000140239 0.000269624 0.000258767 PI 18:0/22:4;O2* 1.8739E-05 5.4574E-05 1.99942E-05 0.00017603 0.000230729 0.00040303 0.000154313 0.000147292 0.000408837 0.000283187 0.000272997 0.000339206 2.39684E-05 5.61419E-05 1.4405E-05 0.000133504 0.000255088 0.000418244 0.000117827 0.000327792 0.000379289 0.000183326 0.000211879 0.000244946 1.67785E-05 3.80324E-05 1.35992E-05 0.000126214 0.000135232 0.00019185 0.000108064 0.000153103 0.000268791 6.89198E-05 0.000168154 0.000170358 PI 18:0/22:4;O3* 9.36394E-06 0.000125128 9.48705E-06 0.000419933 0.000417661 0.000725072 0.000305575 0.000314187 0.00057574 0.000483978 0.000477812 0.000608411 2.70524E-05 0.000181297 1.08028E-05 0.000245536 0.000475218 0.000784296 0.000260303 0.000534463 0.000656067 0.000313312 0.000370839 0.000439342 7.33988E-06 0.000110355 8.6357E-06 0.000233875 0.000246918 0.000382114 0.000208198 0.000296289 0.000456661 0.000118675 0.000315739 0.000354282 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Formula Exact mass super_class main_class Sub class PE 16:0/20:4;O C41H74NO9P 755.5101 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 16:0/20:4;O2 C41H74NO10P 771.505 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 16:0/20:4;O3 C41H74NO11P 787.5 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:0/20:4;O C43H78NO9P 783.5414 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:0/20:4;O2 C43H78NO10P 799.5363 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:0/20:4;O3 C43H78NO11P 815.5313 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:1/20:4;O C43H76NO9P 781.5258 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:1/20:4;O2 C43H76NO10P 797.5207 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:1/20:4;O3 C43H76NO11P 813.5156 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 16:0/22:4;O C43H78NO9P 783.5414 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 16:0/22:4;O2* C43H78NO10P 799.5363 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 16:0/22:4;O3* C43H78NO11P 815.5313 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:0/22:4;O C45H82NO9P 811.5727 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:0/22:4;O2* C45H82NO10P 827.5676 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PE 18:0/22:4;O3* C45H82NO11P 843.5626 Glycerophospholipids Glycerophosphoethanolamines Ox-PE PC 16:0/20:4;O C44H80NO9P 797.5571 Glycerophospholipids Glycerophosphocholines Ox-PC PC 16:0/20:4;O2 C44H80NO10P 813.552 Glycerophospholipids Glycerophosphocholines Ox-PC PC 16:0/20:4;O3 C44H80NO11P 829.5469 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:0/20:4;O C46H84NO9P 825.5884 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:0/20:4;O2 C46H84NO10P 841.5833 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:0/20:4;O3 C46H84NO11P 857.5782 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:1/20:4;O C46H82NO9P 823.5727 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:1/20:4;O2 C46H82NO10P 839.5676 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:1/20:4;O3 C46H82NO11P 855.5626 Glycerophospholipids Glycerophosphocholines Ox-PC PC 16:0/22:4;O C46H84NO9P 825.5884 Glycerophospholipids Glycerophosphocholines Ox-PC PC 16:0/22:4;O2* C46H84NO10P 841.5833 Glycerophospholipids Glycerophosphocholines Ox-PC PC 16:0/22:4;O3* C46H84NO11P 857.5782 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:0/22:4;O C48H88NO9P 853.6197 Glycerophospholipids Glycerophosphocholines Ox-PC PC 18:0/22:4;O3* C48H88NO11P 885.6095 Glycerophospholipids Glycerophosphocholines Ox-PC PI 16:0/20:4;O C45H79O14P 874.5207 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 16:0/20:4;O3 C45H79O16P 906.5106 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:0/20:4;O C47H83O14P 902.552 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:0/20:4;O2 C47H83O15P 918.547 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:0/20:4;O3 C47H83O16P 934.5419 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:1/20:4;O C47H81O14P 900.5364 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:1/20:4;O2 C47H81O15P 916.5313 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:1/20:4;O3 C47H81O16P 932.5262 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:0/22:4;O C49H87O14P 930.5833 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:0/22:4;O2* C49H87O15P 946.5783 Glycerophospholipids Glycerophosphoinositols Ox-PI PI 18:0/22:4;O3* C49H87O16P 962.5732 Glycerophospholipids Glycerophosphoinositols Ox-PI METABOLITES_END #END