#METABOLOMICS WORKBENCH ZJ309_20240802_054706 DATATRACK_ID:5075 STUDY_ID:ST003400 ANALYSIS_ID:AN005581 PROJECT_ID:PR002106
VERSION             	1
CREATED_ON             	August 10, 2024, 9:09 am
#PROJECT
PR:PROJECT_TITLE                 	A Study on the Mechanism of Perinatal BPS Exposure Promoting Obesity Based on
PR:PROJECT_TITLE                 	Metabolomics and Microbiomics
PR:PROJECT_SUMMARY               	Due to increasingly stringent regulations on bisphenol A (BPA) usage, its
PR:PROJECT_SUMMARY               	structurally similar counterpart, BPS, has become widely employed as the primary
PR:PROJECT_SUMMARY               	substitute in various industries such as food packaging. However, recent years
PR:PROJECT_SUMMARY               	have unveiled potential risks of obesity promotion and insulin resistance
PR:PROJECT_SUMMARY               	associated with BPS, particularly during early life stages, although its precise
PR:PROJECT_SUMMARY               	impact remains inadequately understood. Addressing these concerns, this study
PR:PROJECT_SUMMARY               	established a mouse model to investigate the effects of maternal BPS exposure
PR:PROJECT_SUMMARY               	during pregnancy and lactation, combined with offspring consumption of a
PR:PROJECT_SUMMARY               	high-fat diet. The research examined physiological indicators related to obesity
PR:PROJECT_SUMMARY               	and insulin resistance in offspring, evaluated pathological changes in vital
PR:PROJECT_SUMMARY               	organs including the heart, liver, pancreas, white adipose tissue, and brown
PR:PROJECT_SUMMARY               	adipose tissue, conducted metabolomics perturbation analysis across multiple
PR:PROJECT_SUMMARY               	organs, and performed microbiome analysis based on fecal samples. Finally,
PR:PROJECT_SUMMARY               	correlations between phenotype, metabolome, and microbiome were explored to
PR:PROJECT_SUMMARY               	unravel intergenerational effects and mechanisms under BPS exposure, aiming to
PR:PROJECT_SUMMARY               	identify potential biomarkers of its effects.
PR:INSTITUTE                     	College of Marine Food and Biological Engineering, Jimei University
PR:LAST_NAME                     	Li
PR:FIRST_NAME                    	Shuyin
PR:ADDRESS                       	No. 185 Yinjiang Road, Jimei District, Xiamen City, Fujian Province, China
PR:EMAIL                         	164000107@qq.com
PR:PHONE                         	18750682266
#STUDY
ST:STUDY_TITLE                   	A Study on the Mechanism of Perinatal BPS Exposure Promoting Obesity Based on
ST:STUDY_TITLE                   	Metabolomics and Microbiomics
ST:STUDY_SUMMARY                 	Due to increasingly stringent regulations on bisphenol A (BPA) usage, its
ST:STUDY_SUMMARY                 	structurally similar counterpart, BPS, has become widely employed as the primary
ST:STUDY_SUMMARY                 	substitute in various industries such as food packaging. However, recent years
ST:STUDY_SUMMARY                 	have unveiled potential risks of obesity promotion and insulin resistance
ST:STUDY_SUMMARY                 	associated with BPS, particularly during early life stages, although its precise
ST:STUDY_SUMMARY                 	impact remains inadequately understood. Addressing these concerns, this study
ST:STUDY_SUMMARY                 	established a mouse model to investigate the effects of maternal BPS exposure
ST:STUDY_SUMMARY                 	during pregnancy and lactation, combined with offspring consumption of a
ST:STUDY_SUMMARY                 	high-fat diet. The research examined physiological indicators related to obesity
ST:STUDY_SUMMARY                 	and insulin resistance in offspring, evaluated pathological changes in vital
ST:STUDY_SUMMARY                 	organs including the heart, liver, pancreas, white adipose tissue (WAT), and
ST:STUDY_SUMMARY                 	brown adipose tissue (BAT), conducted metabolomics perturbation analysis across
ST:STUDY_SUMMARY                 	multiple organs, and performed microbiome analysis based on fecal samples.
ST:STUDY_SUMMARY                 	Finally, correlations between phenotype, metabolome, and microbiome were
ST:STUDY_SUMMARY                 	explored to unravel intergenerational effects and mechanisms under BPS exposure,
ST:STUDY_SUMMARY                 	aiming to identify potential biomarkers of its effects.
ST:INSTITUTE                     	College of Marine Food and Biological Engineering, Jimei University
ST:LAST_NAME                     	Li
ST:FIRST_NAME                    	Shuyin
ST:ADDRESS                       	No.185 Yinjiang Road,Jimei District,Xiamen City,Fujian Province,China
ST:EMAIL                         	164000107@qq.com
ST:PHONE                         	18750682266
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	BCF-223	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-223.raw
SUBJECT_SAMPLE_FACTORS           	-	BCF-226	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-226.raw
SUBJECT_SAMPLE_FACTORS           	-	BCF-227	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-227.raw
SUBJECT_SAMPLE_FACTORS           	-	BCF-228	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-228.raw
SUBJECT_SAMPLE_FACTORS           	-	BCF-229	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-229.raw
SUBJECT_SAMPLE_FACTORS           	-	BCF-230	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-230.raw
SUBJECT_SAMPLE_FACTORS           	-	BCF-231	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCF-231.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-233	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-233.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-234	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-234.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-236	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-236.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-237	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-237.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-238	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-238.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-243	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-243.raw
SUBJECT_SAMPLE_FACTORS           	-	BCM-246	BPS Treatment:Control | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BCM-246.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-295	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-295.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-297	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-297.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-298	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-298.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-299	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-299.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-306	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-306.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-307	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-307.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4413	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4413.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4415	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4415.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4416	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4416.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4417	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4417.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4418	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4418.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4419	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4419.raw
SUBJECT_SAMPLE_FACTORS           	-	BHF-4438	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHF-4438.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-289	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-289.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-290	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-290.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-294	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-294.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-300	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-300.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-301	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-301.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-304	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-304.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-305	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-305.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4423	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4423.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4427	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4427.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4431	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4431.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4432	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4432.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4433	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4433.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4434	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4434.raw
SUBJECT_SAMPLE_FACTORS           	-	BHM-4452	BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BHM-4452.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-258	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-258.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-261	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-261.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-262	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-262.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-263	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-263.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-264	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-264.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-266	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-266.raw
SUBJECT_SAMPLE_FACTORS           	-	BLF-267	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLF-267.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-247	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-247.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-252	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-252.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-253	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-253.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-255	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-255.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-275	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-275.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-278	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-278.raw
SUBJECT_SAMPLE_FACTORS           	-	BLM-279	BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue	RAW_FILE_NAME(Raw filename)=BLM-279.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-223	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-223.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-226	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-226.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-227	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-227.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-228	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-228.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-229	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-229.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-230	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-230.raw
SUBJECT_SAMPLE_FACTORS           	-	HCF-231	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCF-231.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-233	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-233.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-234	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-234.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-236	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-236.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-237	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-237.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-238	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-238.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-243	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-243.raw
SUBJECT_SAMPLE_FACTORS           	-	HCM-246	BPS Treatment:Control | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HCM-246.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-295	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-295.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-297	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-297.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-298	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-298.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-299	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-299.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-306	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-306.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-307	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-307.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4413	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4413.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4415	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4415.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4416	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4416.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4417	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4417.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4418	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4418.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4419	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4419.raw
SUBJECT_SAMPLE_FACTORS           	-	HHF-4438	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHF-4438.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-289	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-289.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-290	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-290.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-294	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-294.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-300	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-300.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-301	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-301.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-304	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-304.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-305	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-305.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4423	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4423.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4427	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4427.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4431	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4431.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4432	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4432.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4433	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4433.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4434	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4434.raw
SUBJECT_SAMPLE_FACTORS           	-	HHM-4452	BPS Treatment:5mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HHM-4452.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-258	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-258.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-261	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-261.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-262	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-262.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-263	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-263.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-264	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-264.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-266	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-266.raw
SUBJECT_SAMPLE_FACTORS           	-	HLF-267	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLF-267.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-247	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-247.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-252	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-252.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-253	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-253.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-255	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-255.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-275	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-275.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-278	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-278.raw
SUBJECT_SAMPLE_FACTORS           	-	HLM-279	BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue	RAW_FILE_NAME(Raw filename)=HLM-279.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-223	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-223.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-226	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-226.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-227	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-227.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-228	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-228.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-229	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-229.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-230	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-230.raw
SUBJECT_SAMPLE_FACTORS           	-	LCF-231	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCF-231.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-233	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-233.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-234	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-234.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-236	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-236.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-237	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-237.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-238	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-238.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-243	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-243.raw
SUBJECT_SAMPLE_FACTORS           	-	LCM-246	BPS Treatment:Control | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LCM-246.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-295	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-295.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-297	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-297.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-298	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-298.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-299	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-299.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-306	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-306.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-307	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-307.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4413	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4413.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4415	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4415.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4416	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4416.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4417	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4417.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4418	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4418.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4419	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4419.raw
SUBJECT_SAMPLE_FACTORS           	-	LHF-4438	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHF-4438.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-289	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-289.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-290	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-290.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-294	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-294.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-300	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-300.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-301	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-301.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-304	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-304.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-305	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-305.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4423	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4423.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4427	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4427.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4431	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4431.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4432	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4432.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4433	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4433.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4434	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4434.raw
SUBJECT_SAMPLE_FACTORS           	-	LHM-4452	BPS Treatment:5mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LHM-4452.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-258	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-258.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-261	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-261.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-262	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-262.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-263	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-263.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-264	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-264.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-266	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-266.raw
SUBJECT_SAMPLE_FACTORS           	-	LLF-267	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLF-267.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-247	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-247.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-252	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-252.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-253	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-253.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-255	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-255.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-275	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-275.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-278	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-278.raw
SUBJECT_SAMPLE_FACTORS           	-	LLM-279	BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue	RAW_FILE_NAME(Raw filename)=LLM-279.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-223	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-223.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-226	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-226.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-227	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-227.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-228	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-228.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-229	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-229.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-230	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-230.raw
SUBJECT_SAMPLE_FACTORS           	-	PCF-231	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCF-231.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-233	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-233.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-234	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-234.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-236	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-236.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-237	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-237.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-238	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-238.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-243	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-243.raw
SUBJECT_SAMPLE_FACTORS           	-	PCM-246	BPS Treatment:Control | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PCM-246.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-295	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-295.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-297	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-297.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-298	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-298.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-299	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-299.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-306	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-306.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-307	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-307.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4413	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4413.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4415	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4415.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4416	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4416.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4417	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4417.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4418	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4418.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4419	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4419.raw
SUBJECT_SAMPLE_FACTORS           	-	PHF-4438	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHF-4438.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-289	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-289.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-290	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-290.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-294	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-294.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-300	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-300.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-301	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-301.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-304	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-304.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-305	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-305.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4423	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4423.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4427	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4427.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4431	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4431.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4432	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4432.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4433	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4433.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4434	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4434.raw
SUBJECT_SAMPLE_FACTORS           	-	PHM-4452	BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PHM-4452.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-258	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-258.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-261	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-261.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-262	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-262.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-263	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-263.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-264	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-264.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-266	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-266.raw
SUBJECT_SAMPLE_FACTORS           	-	PLF-267	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLF-267.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-247	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-247.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-252	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-252.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-253	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-253.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-255	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-255.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-275	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-275.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-278	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-278.raw
SUBJECT_SAMPLE_FACTORS           	-	PLM-279	BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue	RAW_FILE_NAME(Raw filename)=PLM-279.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-223	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-223.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-226	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-226.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-227	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-227.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-228	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-228.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-229	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-229.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-230	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-230.raw
SUBJECT_SAMPLE_FACTORS           	-	WCF-231	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCF-231.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-233	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-233.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-234	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-234.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-236	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-236.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-237	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-237.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-238	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-238.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-243	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-243.raw
SUBJECT_SAMPLE_FACTORS           	-	WCM-246	BPS Treatment:Control | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WCM-246.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-295	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-295.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-297	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-297.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-298	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-298.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-299	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-299.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-306	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-306.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-307	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-307.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4413	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4413.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4415	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4415.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4416	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4416.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4417	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4417.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4418	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4418.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4419	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4419.raw
SUBJECT_SAMPLE_FACTORS           	-	WHF-4438	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHF-4438.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-289	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-289.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-290	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-290.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-294	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-294.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-300	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-300.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-301	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-301.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-304	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-304.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-305	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-305.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4423	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4423.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4427	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4427.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4431	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4431.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4432	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4432.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4433	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4433.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4434	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4434.raw
SUBJECT_SAMPLE_FACTORS           	-	WHM-4452	BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WHM-4452.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-258	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-258.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-261	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-261.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-262	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-262.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-263	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-263.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-264	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-264.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-266	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-266.raw
SUBJECT_SAMPLE_FACTORS           	-	WLF-267	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLF-267.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-247	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-247.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-252	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-252.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-253	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-253.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-255	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-255.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-275	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-275.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-278	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-278.raw
SUBJECT_SAMPLE_FACTORS           	-	WLM-279	BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue	RAW_FILE_NAME(Raw filename)=WLM-279.raw
#COLLECTION
CO:COLLECTION_SUMMARY            	After 3 weeks of breastfeeding, F1 mice were fed adaptive diet for 1 week,
CO:COLLECTION_SUMMARY            	followed by high-fat diet for 8 weeks.After mouse feces were collected,the
CO:COLLECTION_SUMMARY            	method of euthanizing mice by cervical dislocation. After sampling, Mouse heart,
CO:COLLECTION_SUMMARY            	liver, pancreas, white adipose and brown adipose were collected. After sampling,
CO:COLLECTION_SUMMARY            	the tissues were quickly washed in normal saline. After cleaning, the tissues
CO:COLLECTION_SUMMARY            	were treated with liquid nitrogen and finally frozen in the refrigerator at -80
CO:COLLECTION_SUMMARY            	℃.
CO:SAMPLE_TYPE                   	White adipose,Brown adipose,Heart,Liver,Pancreas
#TREATMENT
TR:TREATMENT_SUMMARY             	Briefly,C57BL/6 pregnant mice were fed ordinary diet under constant temperature
TR:TREATMENT_SUMMARY             	[(23±1) ℃] and constant humidity [(55±5)%], and followed a strict 12 h/12 h
TR:TREATMENT_SUMMARY             	light/dark cycle.Animals were kept in polystyrene rat cages for the experiment.
TR:TREATMENT_SUMMARY             	They were divided into normal saline solvent as control, low-dose BPS group
TR:TREATMENT_SUMMARY             	(0.05 mg/kg/d) and high-dose BPS group (5 mg/kg/d). BPS exposure was performed
TR:TREATMENT_SUMMARY             	by subcutaneous injection. The general state of pregnant mice was observed
TR:TREATMENT_SUMMARY             	daily, and their body mass was weighed once a week. After delivery, pregnant
TR:TREATMENT_SUMMARY             	rats were exposed to BPS in different groups during lactation period, and the
TR:TREATMENT_SUMMARY             	mothers were killed after lactation period. After lactation, F1 mice were
TR:TREATMENT_SUMMARY             	observed in general state every day and weighed once a week. After 3 weeks of
TR:TREATMENT_SUMMARY             	breastfeeding, F1 mice were fed adaptive diet for 1 week, followed by high-fat
TR:TREATMENT_SUMMARY             	diet for 8 weeks. Mouse feces were collected, and mouse heart, liver, pancreas,
TR:TREATMENT_SUMMARY             	white adipose and brown adipose were collected. After sampling, the mice were
TR:TREATMENT_SUMMARY             	quickly washed in normal saline. After cleaning, the mice were treated with
TR:TREATMENT_SUMMARY             	liquid nitrogen and finally frozen in the refrigerator at -80 ℃.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Each replicate of mouse (1 tissue, ~15 mg) was accurately weighted and
SP:SAMPLEPREP_SUMMARY            	transferred to an Eppendorf tube. Then, each sample was added 200 μL of Milli-Q
SP:SAMPLEPREP_SUMMARY            	water,followed by tissue homogenization using the bead-based homogenizer
SP:SAMPLEPREP_SUMMARY            	(Tissuelyser-24, Shanghai jingxin industrial development co., ltd, China) for 2
SP:SAMPLEPREP_SUMMARY            	min at 65 Hz twice and the other samples including white adipose and brown
SP:SAMPLEPREP_SUMMARY            	adipose were homogenize for 2 min at 65 Hz four times. Next, each sample was
SP:SAMPLEPREP_SUMMARY            	added with 800 μL of precooled MeOH/ACN（1:1,v/v）containing standards (i.e.,
SP:SAMPLEPREP_SUMMARY            	0.49 μg/mL of Phenylalanine-d5(Phe-d5), 0.50 μg/mL of Tryptophan-d5(Trp-d5),
SP:SAMPLEPREP_SUMMARY            	0.25 μg/mL of Carnitine C2-d3, 0.40 μg/mL of Cholic acid-d4(CA-d4), 0.24
SP:SAMPLEPREP_SUMMARY            	μg/mL of Chenodeoxycholic acid-d4(CDCA-d4), 0.50 μg/mL of palmitic acid (fatty
SP:SAMPLEPREP_SUMMARY            	acid (FA) (16:0))-d3, and 0.5 μg/mL of stearic acid (FA(18:0))-d3)，the
SP:SAMPLEPREP_SUMMARY            	mixture was thoroughly vortexed for 30 s, use ultrasonic cleaning machine ice
SP:SAMPLEPREP_SUMMARY            	bath for 10 min, stand at -20 °C for 1 h, centrifugation at 15,000 g for 15 min
SP:SAMPLEPREP_SUMMARY            	at 4 ℃. The supernatant was collected and vacuum-dried in a refrigerated
SP:SAMPLEPREP_SUMMARY            	CentriVap concentrator (Labconco, USA), followed by storage at -80 °C until
SP:SAMPLEPREP_SUMMARY            	subsequent analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Negative
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000
CH:COLUMN_NAME                   	ACE Excel 2 C18-PFP (100 x 2.1mm,2um)
CH:SOLVENT_A                     	100% water; 0.01% ammonia; 5mM ammonium bicarbonate
CH:SOLVENT_B                     	50% Methanol/50% Acetonitrile; 0.01% ammonia; 5mM ammonium bicarbonate
CH:FLOW_GRADIENT                 	First maintain 2% B for 0.5 minutes, then linearly increase from 0.5 to 12
CH:FLOW_GRADIENT                 	minutes to 98% B, then rapidly decrease to 2% B at 0.1 minutes, maintain for 8.5
CH:FLOW_GRADIENT                 	minutes,equilibrate until the next injection
CH:FLOW_RATE                     	0.4 mL/min
CH:COLUMN_TEMPERATURE            	50
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive HF-X Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	Xcalibular
MS:MS_RESULTS_FILE               	ST003400_AN005581_Results.txt	UNITS:Peak area	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END