#METABOLOMICS WORKBENCH gabrieltofani_20240903_024337 DATATRACK_ID:5160 STUDY_ID:ST003470 ANALYSIS_ID:AN005705 PROJECT_ID:PR002130
VERSION             	1
CREATED_ON             	September 6, 2024, 3:19 pm
#PROJECT
PR:PROJECT_TITLE                 	Gut Microbiota Regulates Stress Responsivity via the Circadian System
PR:PROJECT_SUMMARY               	Metabolomics of adult mice Amygdala and Hippocampus. Samples collected from
PR:PROJECT_SUMMARY               	conventional, antibiotic-treated and germ-free mice across 4 timepoints of the
PR:PROJECT_SUMMARY               	day. The goal of the project is to investigate the role of the gut microbiota on
PR:PROJECT_SUMMARY               	the circadian patterns of metabolites in the brain. Results indicated that
PR:PROJECT_SUMMARY               	metabolites involved in glutamate metabolism are altered across the day
PR:PROJECT_SUMMARY               	depending on microbial status.
PR:INSTITUTE                     	University College Cork
PR:DEPARTMENT                    	Anatomy & Neuroscience
PR:LABORATORY                    	Microbiome Gut Brain Axis
PR:LAST_NAME                     	John
PR:FIRST_NAME                    	Cryan
PR:ADDRESS                       	College Road, Cork, County Cork, T12 XF62, Ireland
PR:EMAIL                         	gabriel.tofani@ucc.ie
PR:PHONE                         	+353 (0)21 4903500
PR:FUNDING_SOURCE                	Saks Kavanaugh
#STUDY
ST:STUDY_TITLE                   	Gut Microbiota Regulates Stress Responsivity via the Circadian System - Mice
ST:STUDY_TITLE                   	Amygdala
ST:STUDY_SUMMARY                 	Stress and circadian systems are interconnected through the
ST:STUDY_SUMMARY                 	hypothalamic-pituitary-adrenal (HPA) axis to maintain appropriate responses to
ST:STUDY_SUMMARY                 	external stimuli. Yet, the mechanisms of how such signals are orchestrated
ST:STUDY_SUMMARY                 	remains unknown. We now uncover the gut microbiota as a regulator of HPA-axis
ST:STUDY_SUMMARY                 	rhythmic function. Additionally, microbiota depletion markedly disturbs the
ST:STUDY_SUMMARY                 	brain transcriptome and metabolome in key stress response pathways in the
ST:STUDY_SUMMARY                 	hippocampus and amygdala across the day. This is coupled with a dysregulation of
ST:STUDY_SUMMARY                 	the master circadian pacemaker in the brain that resulted in perturbed
ST:STUDY_SUMMARY                 	glucocorticoid rhythmicity. The resulting hyper-activation of the HPA-axis at
ST:STUDY_SUMMARY                 	the sleep/wake transition drives time-of-day-specific impairments of the stress
ST:STUDY_SUMMARY                 	response and altered stress-sensitive behaviors. Finally, using microbiota
ST:STUDY_SUMMARY                 	transplantation we confirm that diurnal oscillations of gut microbes underlie
ST:STUDY_SUMMARY                 	altered glucocorticoid secretion and identify L. reuteri as a candidate strain
ST:STUDY_SUMMARY                 	for such effects. Together, our data offers compelling evidence that the
ST:STUDY_SUMMARY                 	microbiota regulates stress responsiveness in a circadian manner and is
ST:STUDY_SUMMARY                 	necessary to respond adaptively to psychological stressors throughout the day.
ST:INSTITUTE                     	University College Cork
ST:DEPARTMENT                    	Anatomy & Neuroscience
ST:LABORATORY                    	Microbiome Gut Brain Axis
ST:LAST_NAME                     	John
ST:FIRST_NAME                    	Cryan
ST:ADDRESS                       	4th Floor, Block E, Food Science Building, University College Cork, College
ST:ADDRESS                       	Road, Cork, Ireland.
ST:EMAIL                         	j.cryan@ucc.ie
ST:PHONE                         	+353 (0)21 4903500
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
SU:AGE_OR_AGE_RANGE              	8-14 weeks
SU:GENDER                        	Male
SU:ANIMAL_ANIMAL_SUPPLIER        	Taconic Biosciences
SU:ANIMAL_LIGHT_CYCLE            	12h Light/Dark
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	GF_49	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_51	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_52	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_24	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_25	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_28	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_26	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	GROUP_ID=GF_ZT5
SUBJECT_SAMPLE_FACTORS           	-	GF_32	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_36	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_41	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_42	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_43	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_45	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_47	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_48	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	GROUP_ID=GF_ZT11
SUBJECT_SAMPLE_FACTORS           	-	GF_91	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_92	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_93	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_94	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_95	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_96	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_97	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_98	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	GROUP_ID=GF_ZT17
SUBJECT_SAMPLE_FACTORS           	-	GF_54	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_55	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_56	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_57	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_59	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_60	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_61	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	GF_53	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	GROUP_ID=GF_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_6	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_7	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_8	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_9	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_10	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_12	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_13	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	GROUP_ID=CV_ZT5
SUBJECT_SAMPLE_FACTORS           	-	CV_16	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_18	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_19	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_20	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_101	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_102	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	GROUP_ID=CV_ZT11
SUBJECT_SAMPLE_FACTORS           	-	CV_66	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_67	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_68	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_69	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_70	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_71	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_122	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_123	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	GROUP_ID=CV_ZT17
SUBJECT_SAMPLE_FACTORS           	-	CV_78	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_79	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_80	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_81	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_82	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_83	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_117	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	CV_118	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	GROUP_ID=CV_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_72	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_73	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_74	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_75	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_76	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_77	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_84	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_86	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	GROUP_ID=ABX_ZT5
SUBJECT_SAMPLE_FACTORS           	-	ABX_62	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_63	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_64	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_65	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_87	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_88	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_89	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_90	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	GROUP_ID=ABX_ZT11
SUBJECT_SAMPLE_FACTORS           	-	ABX_105	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	GROUP_ID=ABX_ZT17
SUBJECT_SAMPLE_FACTORS           	-	ABX_106	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	GROUP_ID=ABX_ZT17
SUBJECT_SAMPLE_FACTORS           	-	ABX_107	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	GROUP_ID=ABX_ZT17
SUBJECT_SAMPLE_FACTORS           	-	ABX_108	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	GROUP_ID=ABX_ZT17
SUBJECT_SAMPLE_FACTORS           	-	ABX_119	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	GROUP_ID=ABX_ZT17
SUBJECT_SAMPLE_FACTORS           	-	ABX_121	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	GROUP_ID=ABX_ZT17
SUBJECT_SAMPLE_FACTORS           	-	ABX_109	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_110	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_111	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_112	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_113	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_114	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_115	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
SUBJECT_SAMPLE_FACTORS           	-	ABX_116	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	GROUP_ID=ABX_ZT23
#COLLECTION
CO:COLLECTION_SUMMARY            	Mice were transferred to a cull room and immediately decapitated. Tissues were
CO:COLLECTION_SUMMARY            	then harvested, stored in PCR-grade tubes and flash-frozen in dry ice. Samples
CO:COLLECTION_SUMMARY            	were stored in -80°C until further analysis.
CO:SAMPLE_TYPE                   	Brain
#TREATMENT
TR:TREATMENT_SUMMARY             	Treatment = Conventional (Controls) - CV, Germ-Free - GF, Antibiotic Treated -
TR:TREATMENT_SUMMARY             	ABX. Timepoints = ZT (Zeitgeber) 5, 11, 17 and 23. Group_ID = Treatment +
TR:TREATMENT_SUMMARY             	Timepoint (eg. GF_ZT5, GF_ZT11) Details on antibiotic treatment: Mice received
TR:TREATMENT_SUMMARY             	antibiotic treatment in ad libitum drinking water for a period of 14 days. The
TR:TREATMENT_SUMMARY             	antibiotic cocktail consisted of ampicillin sodium salt (1g/L), gentamicin
TR:TREATMENT_SUMMARY             	sulfate (1g/L), vancomycin hydrochloride (0.5g/L) and imipenem (0.25g/L)
TR:TREATMENT_SUMMARY             	(Discovery Fine Chemicals). Water containing antibiotics was replaced every two
TR:TREATMENT_SUMMARY             	days for the duration of the treatment and prepared freshly every time. Cages
TR:TREATMENT_SUMMARY             	were randomly assigned to either vehicle or antibiotic treatment.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	1. Add pre-weighted sample and stainless steel beads in an extraction tube. 2.
SP:SAMPLEPREP_SUMMARY            	Add MeOH/Water (1:2) 3. Place the ET-1s into the pre-cooled Bead-beater and
SP:SAMPLEPREP_SUMMARY            	homogenize for 4 x 30 sec at 30 Hz. 4. Ultrasonicate the samples for 5 mins 5.
SP:SAMPLEPREP_SUMMARY            	Centrifuge the samples for 5 minutes at 18000 RCF and 4 °C and collect the
SP:SAMPLEPREP_SUMMARY            	supernatant in a Phree filter. 6. Repeat step 2-5 7. Centrifuge the Phree
SP:SAMPLEPREP_SUMMARY            	filters for 5 minutes at 1800 RCF and 4 °C. 8. Collect the filtrate and
SP:SAMPLEPREP_SUMMARY            	transfer it to a new extraction tube, 9. Dry the extracts under nitrogen gas.
SP:SAMPLEPREP_SUMMARY            	10. Reconstitute 20 x the initial sample weight with Eluent Mix (10% Eluent B in
SP:SAMPLEPREP_SUMMARY            	Eluent A) and shake @ 1000 for 3.5 min therafter vortex for 10 sec. 11. Transfer
SP:SAMPLEPREP_SUMMARY            	100 ul of the liquid to a filter plate and centrifuge them for 2 mins at 1800
SP:SAMPLEPREP_SUMMARY            	RCF and 4 °C. 12. Collect the filtrate and dilute five times in eluent A.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Thermo Scientific Vanquish LC coupled to a Q Exactive™ HF Hybrid
CH:CHROMATOGRAPHY_SUMMARY        	Quadrupole-Orbitrap
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Vanquish
CH:COLUMN_NAME                   	Waters ACQUITY UPLC HSS T3 (150 x 2.1mm,1.8um)
CH:SOLVENT_A                     	100% water; 10 mM ammonium formate; 0.1% formic acid
CH:SOLVENT_B                     	100% methanol; 10 mM ammonium formate; 0.1% formic acid
CH:FLOW_GRADIENT                 	0.0 min 0% B, 2.0 min 0% B, 4.0 min 35% B, 6.0 min 90% B, 14.0 min 90% B, 14.1
CH:FLOW_GRADIENT                 	min 0% B, 15.0 min 0% B
CH:FLOW_RATE                     	300 µl/min
CH:COLUMN_TEMPERATURE            	30°C
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive HF hybrid Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	Metabolomics processing was performed untargeted using Compound Discoverer 3.3
MS:MS_COMMENTS                   	(Thermo Scientific) and Skyline 22.2 (MacCoss Lab Software) for peak picking and
MS:MS_COMMENTS                   	feature grouping, followed by a in-house annotation and curation pipeline
MS:MS_COMMENTS                   	written in MatLab (2022b, MathWorks). Identification of compounds were performed
MS:MS_COMMENTS                   	at four levels; Level 1: identification by retention times (compared against
MS:MS_COMMENTS                   	in-house authentic standards), accurate mass (with an accepted deviation of
MS:MS_COMMENTS                   	3ppm), and MS/MS spectra, Level 2a: identification by retention times (compared
MS:MS_COMMENTS                   	against in-house authentic standards), accurate mass (with an accepted deviation
MS:MS_COMMENTS                   	of 3ppm). Level 2b: identification by accurate mass (with an accepted deviation
MS:MS_COMMENTS                   	of 3ppm), and MS/MS spectra, Level 3: identification by accurate mass alone
MS:MS_COMMENTS                   	(with an accepted deviation of 3ppm).
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	Peak area
MS_METABOLITE_DATA_START
Samples	GF_49	GF_51	GF_52	GF_24	GF_25	GF_28	GF_26	GF_32	GF_36	GF_41	GF_42	GF_43	GF_45	GF_47	GF_48	GF_91	GF_92	GF_93	GF_94	GF_95	GF_96	GF_97	GF_98	GF_54	GF_55	GF_56	GF_57	GF_59	GF_60	GF_61	GF_53	CV_6	CV_7	CV_8	CV_9	CV_10	CV_11	CV_12	CV_13	CV_16	CV_17	CV_18	CV_19	CV_20	CV_101	CV_102	CV_66	CV_67	CV_68	CV_69	CV_70	CV_71	CV_122	CV_123	CV_78	CV_79	CV_80	CV_81	CV_82	CV_83	CV_117	CV_118	ABX_72	ABX_73	ABX_74	ABX_75	ABX_76	ABX_77	ABX_84	ABX_86	ABX_62	ABX_63	ABX_64	ABX_65	ABX_87	ABX_88	ABX_89	ABX_90	ABX_105	ABX_106	ABX_107	ABX_108	ABX_119	ABX_121	ABX_109	ABX_110	ABX_111	ABX_112	ABX_113	ABX_114	ABX_115	ABX_116
Factors	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:GF | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:CV | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT5	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT11	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT17	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23	Sample source:Amygadala | Treatment:ABX | Zeitgeber_time:ZT23
1-Methyl Adenosine	621886	341183	567970	768697	1074042	1130616	426581	482477	821769	757200	786172	1198265	1118568	1222454	1055991	813273	820903	1148999	1001464	996448	714098	814420	1278850	1245165	1025120	1068567	1604770	1103850	1988975	1282550	1023660	1497793	1290919	1260375	1058795	1155968	1019965	1138487	1228595	1289417	1271521	1385389	492363	1608862	1376111	1448103	1364329	1064442	713094	1056651	897860	981709	1106454	897401	820964	895889	1055058	1220920	1009628	1091789	1402010	1213565	1021424	1033278	1230658	1000292	1114537	926357	743965	769014	1050659	956834	820237	1320411	1410086	1223541	832272	587320	1217113	1285413	1146471	320198	1013415	893895	1275541	1226021	1199847	1205066	1669121	993459	981684	1103522
3-Methylhistidine	725794	354666	818724	1048665	828668	1285889	558650	1375507	1719089	1535328	3083663	3342227	2621597	3464576	3439991	1037524	1207008	1481128	610981	991226	1006802	1136272	1257677	1138789	919374	1004906	1264928	1004095	1473243	1321458	1301072	2241791	1722976	2423991	1975620	1537245	1360165	1221725	1446893	2830745	2401688	3784382	1342773	3457256	3269621	3526567	1809850	1255742	1031517	1657413	1392723	1401153	1430456	1548006	614016	944164	815743	1011178	926923	829743	1125788	1091235	1209375	1547507	1542526	1184978	929522	1048921	725841	707690	2625736	2599385	1828956	2591993	2909436	2617113	2842472	1308689	917386	950427	862799	276549	1005067	988404	700411	536116	740946	761824	836379	504402	625353	788530
4-Guanidinobutyric acid	2859458	762714	1691661	1442716	2094380	1547172	1046747	1479729	1514074	2078144	3112952	1667984	1846133	3281794	1799886	1667559	1491159	2709907	5803205	3006758	1634577	1861530	4032939	4183860	3079650	2296273	2251971	2862407	5438192	2132666	2373199	3743584	2471276	3078189	2585537	3433002	1774933	4018612	2091721	2490107	2880572	1915177	1745462	2688277	2740093	4562124	2488276	2527422	904123	1159897	1231781	1587783	2143407	1235160	3160029	2387816	1694131	1755929	2005706	1974423	2226410	1872143	2447355	1561840	1827333	3971051	2112830	1421590	1954527	1195799	1937400	1434049	1452299	1888611	2286335	2063893	2117940	1085628	2407072	3118727	2905030	1172355	2267417	1703136	1801174	2436340	2716931	2247000	2562019	1714166	2222848	3305069
4-Hydroxybenzaldehyde	1726683	1183982	1832015	1872122	2552841	2089438	1064682	1649338	1976001	2522862	3673054	2077560	2519272	3804896	2062272	1751652	1896671	2513330	2434777	3096226	2353085	2407471	4576437	3190028	2734728	3524590	2645596	3644863	5382542	3281458	3334010	4785576	3815147	4090713	3761124	4455506	2464444	5089713	2392997	3696511	3449765	2701880	2889054	2733215	3377441	5354660	3026443	3452075	1362598	1475128	2084537	2168290	2708702	1764861	3751380	2749376	2298450	2332819	2304322	2280702	1670924	2245574	2842666	2046467	2527577	3767290	2833278	2009946	2325762	2400074	2716646	2025517	2258594	2569173	3268941	1914016	3644008	2076893	3496073	4795279	3814490	1737170	3500660	2997998	2436751	3292123	3763429	3261603	3663066	3013831	3929793	4309815
Acetylcarnitine	23649045	17024637	37065812	24183428	35022936	41605693	15171316	7773282	34932313	26788210	40893326	41190176	34887458	58054734	24564938	25980774	6170283	8153834	5464401	6225509	10066563	8226170	10056504	59257307	35541544	33235310	42535601	44947378	107040221	35735537	44023363	8235252	27322977	24506171	50109871	35840385	15485202	13014290	28310533	25782850	27304034	25373432	15013911	31323623	30904051	49713800	29819486	24296242	23467826	25745915	28657573	17979928	27167865	37252735	51896251	45994782	41535237	42824771	27835796	28709627	25541936	33292315	15197467	12155017	9593518	9752272	9420820	25540563	26113465	24236458	25664060	18958021	12430147	12224025	16718448	6579850	10069275	4446872	13903836	13386411	9764589	3190142	22049115	13649535	6835301	7519670	9574492	9731705	30339909	14229261	9985672	9859236
Adenosine	19787057	38050933	85815767	98719541	173746334	1562586	540155	22345027	56645661	106526045	101679380	722083	891949	1488043	826765	6144209	76158737	164904306	136502266	105260939	127217175	100627470	196537067	63212105	11760452	1555889	1280122	1475944	2439590	1616395	1569383	117590882	46356593	1279088	3801372	3195334	1154452	113942828	1791447	1818423	56464346	1261696	5575421	2015638	1339167	56007882	29196113	110376495	1124862	1276054	769024	119026189	195862307	912593	159822267	155421841	131681982	1738584	1728024	17407414	1635340	135965709	206619301	1479266	1711045	79335587	184160265	94302996	149502676	106983983	108441735	98694498	66066613	913522	1665955	15163806	150111643	70231029	1694190	106206262	45455257	79301531	109093598	103182487	1639304	169717426	85228251	111625459	1698484	149588602	147647067	62169934
Arginine	28653690	13218733	18974815	33656397	33333216	47074979	16968670	28744587	31462344	38367621	30225127	36336091	39265676	47911420	35451956	31809682	26382856	24276492	25909302	29905299	25417916	22919801	29103187	38950657	43310207	55456899	61263901	60907622	58856425	39625399	33470105	41425767	45870945	47498066	37083199	55618917	42264823	40715730	41621622	47779341	36527160	47794693	21444629	72118231	61860393	55940510	39252427	32712590	39372929	40033942	35041415	29724486	30686775	26860040	25469797	32482741	34262846	49950019	41334220	44397887	62129355	35907231	27083907	40483644	43797962	38214174	23230638	29254013	30409566	23891337	30071074	31233779	30401078	37969501	43771490	47737051	38435750	19043240	33296354	43206685	40677635	12974885	30294881	32581136	47075966	38224783	38885186	40507653	51808638	29539732	28608400	38933839
Carnitine	81585611	27161132	59846322	78163754	104368486	96764534	42153640	81347782	85877417	77388421	78481959	100082118	95941561	124028234	107120040	102367389	100550061	140662844	101017741	114639002	84902971	99350024	149644159	125095074	96015465	91366130	112227821	111359864	183137230	83715889	86323096	119553641	89015566	106755489	78890770	104783047	72953610	66378551	66336460	91274166	99886996	98809564	32656499	140811932	136861987	141505720	122411114	83191995	58310558	82857169	70791445	107644067	81994104	59070788	59343639	78679616	78024885	76893976	102486428	109830386	125736473	89964413	81545169	89317281	97657190	108921904	89749226	74878993	50048696	57562768	77499380	84554287	65737318	99097192	105566996	138720277	84151689	53793455	102699691	94243546	120948195	27492566	80439539	59753349	94979586	100850074	102634911	97602333	103627291	66798428	75591371	129455741
Carnosine	1306851	552290	1805151	1121696	1250563	1750018	752498	959663	1533725	1088427	1027871	1468709	1284178	931743	1535142	1381462	1057603	1191241	841245	795481	850850	947143	1189266	2039925	1051904	908286	1650777	984586	1523738	1156815	1820109	1220363	960353	1445445	1161588	701597	1261039	778832	1336283	1083609	1315788	1439569	704373	2051719	1639416	1335235	1110297	1010743	1083184	1121363	742087	1086792	1107065	1187198	1062860	1108451	1330303	1376502	1469096	1689183	1698513	1312005	907769	960071	894303	1244879	757746	1080103	925469	1032287	1058537	1554354	1058837	1314840	1069828	2522273	1052657	964623	858194	844485	1210495	558751	1089995	717061	1326971	1142533	996392	1189508	1164304	998941	1009488	1255684
Choline	639513813	228001332	431893829	696017062	863615633	938207302	363723412	464056214	673148399	752605016	743479414	1034484834	1019003718	1761694457	1054212049	750444172	752722970	832360050	712495801	932791087	634772925	608932411	1121962368	1060341758	864706846	1305805251	1192814288	1653643355	1871173074	1098788718	1045166091	1222587847	1280024187	1316856584	1285131264	1776227486	1101169774	1580871716	1060731729	1371257704	1121889638	1238845810	802809777	996938183	1195722625	1480406561	1066242361	871781293	833459287	1025296401	1290737966	862276399	984141464	876247616	921881093	949205628	888852069	1167388378	881404402	926389483	952952666	869101141	899887829	1171613873	1339167800	1361037525	786670332	815503714	788679807	612245181	833655561	819055609	773823646	1229564889	1571410234	753836299	1064560953	557986737	1273778749	1852031629	1118769115	457057306	900887551	882761090	1042880718	914156457	1130389944	1015954045	1601955718	633267342	897630893	1017183429
Citrulline	867803	345485	564818	1586953	2470847	1583982	1875306	795018	2077907	1835992	5007174	2255542	2230123	3509577	2181288	1826007	1224486	2226605	1679455	2075507	1614125	1827406	2555118	1212744	1319838	1419922	1220570	1308046	2383794	1574849	1214191	2849689	1673561	2585302	1220932	2007928	1426782	2335601	1393296	2496040	1512940	2368417	644774	1737580	2094276	3556098	1952482	1828286	884496	1232065	1286833	1459294	1785143	1076145	1472456	1772240	1702611	1544553	1054165	1050943	926071	1548314	2659281	1926851	1791314	1932425	2017445	1244828	1347698	1281558	2286712	1222510	1484634	2248863	2381349	764209	1236599	855881	2029491	1623984	1367610	462533	1975714	1375438	1676216	1271813	2200957	1503174	2291680	719862	1965798	1474205
Creatine	531930464	374527392	505506720	618313216	727070464	732762816	456020384	554521216	671462464	600072384	647293696	743654016	722717120	809936576	736330496	710077696	709980672	731882176	666262592	727965056	593235648	648597440	750794112	720476608	683071360	644568576	757582336	655142592	921067136	671449024	613232704	772257472	717121536	730892736	695831680	714389696	637483520	625172544	621167296	699962048	745493568	732459264	430739840	856432128	789244736	856684032	715616576	603270464	566087168	655832384	621761024	655832128	705343808	598147328	637071168	648534080	651151104	644843968	711127744	703272768	798269888	700034752	665593920	647642752	682158208	662711808	629103040	663559616	527457504	587916288	667679808	675642688	579861248	677948736	707786176	811182464	606975936	468692864	667327744	691341888	727234304	331284448	661997248	598112960	730792640	668717504	732672448	720412416	720169984	585668928	634723264	767424448
Cytidine	4237791	3688187	6021778	4746905	4910816	8141261	3032890	3924202	5395143	7698568	7833235	1664974	9246608	20572485	6794912	7451061	6883409	4573479	4889916	7216727	4333066	3077314	5370063	8686791	8407876	16916547	9126886	19758747	29368890	18301514	16120113	7885162	12591495	18616694	23422317	21694763	6094601	14139955	10743272	17158682	9975825	14519912	9017688	13930141	10370185	12854941	8149829	5270666	670693	5661023	13799474	5281503	7491381	3097867	7519676	7919340	7589996	14150584	9859239	8201053	1161529	7483234	5969708	6467666	11710088	11885563	6161053	8413032	5493259	6517164	7354511	7682471	7460841	4271156	14346849	12311253	12883698	3670355	11975382	18908998	9531758	2153283	7006721	8350918	3359495	7692936	10468243	8174338	9022730	5813596	7420772	8584049
Glutamic acid	21039881	12698302	22134518	30095397	37825577	49388212	19029719	19270278	35632236	30433600	39543419	46965908	37552313	53999319	41744420	44156335	40648316	45851299	38168120	43515622	29985688	31429300	40933571	37610417	34471945	32271951	40310509	38739846	52048021	39382705	29533668	47413336	42179140	43598776	45268033	40647169	29643430	36970661	34320222	43260019	45607439	47636449	20390230	48159804	45938223	65200924	45749629	35847687	27035812	35946002	36902741	38820315	44345723	35873623	40631847	45687460	41912550	44300816	43284724	39345052	39400770	41817296	39255513	34913683	38326857	26885742	34658797	37121830	22746027	29784619	36974261	34546296	25252275	37090697	39031593	36874244	29586309	18557213	34006923	44411338	38527468	9280241	36503903	33790046	38522149	35726208	41532650	39416926	43110341	28434632	39050549	37712151
Glutamine	10016919	5500083	9722018	15978790	19290829	19088848	8051371	10130064	14854243	13567059	18609663	22292772	20466192	26347732	21656406	21661772	18604941	20622069	16641665	19856980	14954003	16291936	23173021	23261491	18841591	16725278	19312505	18692407	38710268	20036956	16411081	25166604	22513994	22850866	17128766	20843935	16629607	19770091	17223994	20164371	21776185	20549010	7718435	20006208	22505624	29803799	21713893	18028807	13212865	17731488	17107387	18153419	20974258	15174676	17130441	19371717	19328732	19767723	18163864	18402063	19786800	21842718	18521265	18700252	18466036	15337813	17624715	16675979	12561875	14816778	16959805	16974324	13350180	18153786	21093642	17281204	15455827	10299550	18757261	20087626	21424865	4947689	19301561	15069898	21180698	21529384	22981816	22021530	24121211	14967970	16332251	20743611
Glutathione oxidized	1984090	1372668	2721276	2988346	5151161	842104	1143663	1864722	5260585	2065713	4162345	4406856	2069201	2940308	2944306	7138411	6561921	4398567	4124442	5234745	3424983	3572846	3877251	4477667	2939106	428004	7089	639128	2652076	451939	663096	4523333	2322299	1574156	405656	1333345	1398052	1240635	343998	4018427	5394521	362438	187832	434100	2235363	5667859	2039011	2800128	3810369	553420	1570317	5555752	5245423	1638818	3683064	6336295	4968568	470820	2439597	4956588	5206852	4768214	4634584	4862179	3360957	1361368	4233615	4485043	3440867	3645594	4126443	4883663	2908603	879555	1021728	4391386	3075148	1913779	873039	2140504	3204620	713487	4009739	1626492	2651474	4897367	5038859	4358316	496329	3186071	3939557	3983156
Histidine	10233540	8037030	8901323	11575762	10914010	16963635	12347624	12313320	12681452	14364936	18928573	13755554	17360066	26970221	14601364	11766682	10516268	13213710	14495341	10585000	10777043	12441534	15057713	13111059	15919883	25390563	19547479	38329785	25086292	17984882	17606076	14057316	14777587	16682628	18150657	28373102	13359750	29475628	15397885	17649929	15291345	18227399	11695093	20005524	17704517	19239731	14362251	12788529	13133638	13150658	15359627	9948712	12274799	13071614	15328133	11149312	11445084	16504007	14098582	12946729	15653239	12353704	11836500	13415704	15622694	19033192	12086843	11023063	10251945	11098114	13588389	12896239	9232627	14131343	18381844	13710678	14953739	10634491	15690197	19977000	13737170	7087298	13203968	10670332	12659917	12463126	11511834	10461468	18087053	12375922	3356740	10808838
Hypoxanthine	3089734	1262688	2015512	3357220	3431957	3227132	1261524	3138328	4354205	3708467	4198537	4480567	5622874	7410679	5158276	5748249	4069472	3816301	4159885	5182448	2971620	3566318	4571903	5350537	5339565	5484609	7219897	6133480	8450937	4284170	3842964	5837096	5873788	6700089	2777973	5650078	5597259	4065961	4413337	5418190	5318032	5956263	1065095	7510785	7674297	9070554	6852977	3924084	6786742	6415962	3424099	3523412	2411972	1467567	2636655	2879413	3137127	3416236	3604025	5252809	10455321	3469135	2645066	6768015	5438884	3281554	2661167	3344854	2144008	2496490	4047310	3999782	3947646	4723056	5204078	7128345	4094910	2387862	4042327	3659145	5982646	983920	4159814	3375506	5721868	3668641	6147556	5338353	5996348	2656488	3269139	5903940
Inosine	47588324	35741190	45906923	52816811	60094749	79086397	50371372	49493815	69438685	53768580	56004794	77831033	68341986	79281896	73402547	62495405	69981012	67542469	55139166	65998089	50449253	59954300	61737604	69496367	59193785	56859263	69540073	59131184	91718873	70852680	62639715	73276078	73705670	73090011	80304044	65060745	58840462	58199032	66006389	75608440	65307885	72963991	54178127	66577721	73982558	77201294	71463141	55561038	43701877	58647733	68388474	62021793	60153819	69081945	50710700	55680329	65217704	67087661	72394753	65497171	54687373	63469761	50885354	54756800	70944059	62045342	55203682	61786783	43048911	58513894	61082594	60598998	54675151	73541426	75508958	66128143	49097436	48227754	66550123	65652485	66112711	30130762	64888562	56808082	71682363	57522518	70425533	62318646	74949804	51068992	53786305	64445081
Lysine	1409240	739660	815768	1585700	1801735	1868115	737673	1208344	1730678	1564594	1493912	2067727	2434393	2939421	2053657	1473669	1405940	1117388	1425850	1624662	1165177	960713	1264707	2009955	2098482	2727062	2892654	3431563	3849221	1680495	1524258	2451815	2320006	2374339	1903791	3343084	2331792	2221725	2053697	2647009	2422543	2026964	915581	3257472	3542034	2704687	1744900	1572175	1646074	1741608	1676611	1446699	1370534	841753	1087254	1510342	1435209	1689935	1383993	1620043	2408367	1422384	1632090	1960625	2322294	1562053	1184048	1661038	1456041	1096861	1402515	1779730	1713709	2154599	2586307	2221321	2038317	885485	1240143	1995923	1966400	469468	1228721	1540774	2043499	1640149	1652311	1594033	2239402	1152312	1123531	1718403
Malic acid	644391	359162	767256	873625	918140	1529752	414878	379576	1230082	453042	595932	1916008	1200611	941026	1083626	1525606	1707154	1169505	1367848	942234	619179	863382	532690	1019543	1242330	1069519	2900583	971341	1960160	750719	621314	676253	935401	633046	997050	791534	1408398	393357	917540	1276146	1232012	931342	311784	4773278	2761573	841308	923313	462483	3233726	2256297	932941	1147178	874627	615992	502548	912048	838143	551583	1068152	1421359	4107586	1057666	544658	3187975	2130459	364313	637610	1127415	500920	488016	512872	1200929	754445	1592028	816504	2194855	582935	314352	426631	350603	752529	61443	429506	486432	2685738	859868	878057	1242033	1185106	524163	432100	461033
Methionine	5840245	2508053	3370572	9083933	10189597	12752332	2776242	5926078	9762872	9089012	7175696	12600845	13778625	19309485	11471594	10072191	9213824	8939294	9876731	9954623	7258009	7211972	10357081	11355418	12990716	16100339	16951337	18304145	24167503	11666834	9122938	14531275	14105445	16560783	10627278	19294005	11987490	14668173	11535680	17272153	13439323	13909669	4661626	20132931	19223944	19185139	14540573	10569064	10984801	12552098	10913039	10186051	9856753	7351748	6805080	8662600	10169580	15022618	10795836	12489298	15936585	10877868	9433032	12301543	12897420	8334043	8299809	10070232	6777247	6834862	9323916	9601728	9026001	14248042	15320868	12477741	11541182	4557604	9937782	14178925	12902274	2576281	10915536	11104162	14786434	12763083	13487362	13300882	18197586	9641519	9019447	11523219
Methionine sulfoxide	1063104	219012	433495	808627	900175	544357	1354531	675108	831768	976736	3337332	656090	725343	1463368	626518	699927	565602	913738	1536115	1910092	695933	868439	1514358	1277561	1094023	804500	507093	722029	2317314	804047	639993	1124828	890335	1213410	697751	1646868	578462	1389386	565060	907220	1190121	528923	470372	648861	780253	2093890	899449	778841	378211	395992	632737	433012	592980	347372	2430487	1961584	630422	539222	589689	530392	508076	537847	1235527	556391	705847	1862613	868703	528145	1500810	384195	733467	393912	755851	511532	662812	542043	1093748	540408	701580	749952	926818	364334	637823	675535	545595	976799	990870	672450	619125	662960	732818	1288525
N-Acetyl-arginine	954155	537538	913998	1189180	1644573	1631148	599535	994812	1198238	1186140	1282325	1575721	1206818	1668956	1501270	1365894	1427478	1789714	1419858	1612861	1048083	1287678	1773639	1838933	1260089	1152004	1475403	1491087	2568794	1235949	1222559	2097944	1732838	1948706	1446691	1565653	1185131	1295836	1248393	1501549	1505083	1384235	540295	1472540	1759358	1914347	1591527	1262612	830345	1028550	943715	1332792	1451033	1060744	1194303	1296635	1537634	1537172	1575763	1852355	1721605	1895020	1560342	1492700	1469232	1430218	1370215	1352728	905208	1172510	1141871	1040539	760709	1169276	1283446	1377873	967613	560863	1204532	1256117	1486371	305250	1080290	732529	1392842	1591398	1717024	1573445	1837257	1246124	1363103	1814666
N-Acetyl-aspartic acid	18498604	9694133	21128245	35820955	42568701	41721192	15221786	13564509	35866595	26167906	41882708	47473972	40751557	59544923	47041146	51670605	42599893	62871200	44850776	47849334	30977700	37536149	58220403	51801185	33498704	15851843	74678	30398305	78714053	37287448	30634669	52544862	40208805	52718020	33391301	38537649	11452878	42546722	17684469	46830982	48849222	35844471	13758528	106162	26682267	79406638	55918270	31500222	19854844	32852564	30869319	36970752	48066297	28732581	36805863	42440858	45324661	32783183	28330961	32807927	12114552	45268444	42180830	34536465	36461716	25537163	40431844	35496216	23895824	28622222	42671359	36841407	24526190	38886673	42755784	19935446	31024107	18881493	40967958	48567232	38561553	7998213	42400005	33082817	41838587	42923650	50975842	46242223	49235191	31700283	40307292	38311677
N-Acetyl-glutamine	863956	512499	990031	1032940	1176248	1258247	613968	902664	1088444	936219	1263642	1479878	1244482	1847147	1396262	1226812	1097625	1456819	1186354	1346590	965426	1162122	1615727	1712945	1414999	1461788	1250390	1386483	2581585	1262989	1225354	1729971	1276563	1486802	1302126	1330531	1221172	1346147	1701471	1483955	1387242	1338818	721961	1507390	2144257	2319147	1617718	1473834	1016113	1173011	1101125	1177931	1251768	1012457	1515198	1421838	1302165	1572393	1786068	1705534	1969856	1324707	1241589	1226596	1273482	1462874	1314851	1155218	1059519	1047299	1226826	1128829	953197	1261690	1352428	1519671	1120459	817276	1272221	1130768	1508798	488385	1255310	933905	1556658	1422930	1490033	1496425	1653273	1167093	1223603	1648370
Nicotine amide	210039604	129403048	224300944	256525276	343288507	354475079	164585546	210794712	289209202	259489083	297903188	345477927	321595495	387386445	333088872	318687875	310291282	341845678	297347639	346511340	246305835	269155481	362148579	354645866	312930225	278364618	345847325	310476947	527496774	302091614	271502200	374670912	342787916	368473528	331648955	346843238	277960843	292402268	299824549	332475436	338352961	342939969	165818129	407587926	373857940	456976127	355660155	282077330	233479289	297702775	296557163	307991372	312666229	270949595	290323775	323747072	306382395	306239124	314941985	327771012	363100611	330431926	317427506	306571845	322210331	297265563	296694971	306624085	228187124	251583063	288650917	288308015	243946139	308085039	329997971	356931062	277273671	172587610	303503643	333279084	348065467	105327287	312306880	271703719	348766223	316658112	360831068	343379290	367041432	265817377	298689896	373554728
Pantothenic acid	278379	130163	244825	477762	692659	452042	199460	229102	477831	374530	471181	653976	621259	854148	706132	490339	495796	659692	468771	535429	409676	442394	758257	733447	486929	414666	597553	519979	1127446	490941	428728	792847	626689	573027	355001	463191	431862	430770	424553	492314	580520	563898	175518	509702	678295	866359	705675	510253	300543	515877	378614	522822	526451	336513	375896	427528	450239	526788	406056	452537	431683	512928	580907	456245	524622	504462	540022	450087	346372	355455	508424	443616	364142	511674	628747	464293	441679	263779	451923	561621	521968	132518	496344	390316	549829	552630	564925	549593	693484	387147	475943	461612
Phenylalanine	9252476	3329966	5107021	11715630	15592621	16573562	4839403	7726631	13405293	13545290	13677278	16249423	19595259	29199373	15792923	12285799	11081725	10337372	10788576	15759680	9604015	9273652	15033346	17857640	18228432	22288345	23570345	27471826	39128326	15817573	11858449	22071560	19464980	23628231	13757926	29815303	17351665	22973729	14876818	24410693	20079044	19952563	7691734	30450852	28281404	31381646	17289329	14517330	13407138	15387985	14501414	12696503	13273615	8304881	11314215	14134403	12800294	20685314	13456328	16880255	22063676	13831426	13248802	16112028	17743791	14137355	10889345	12224027	10866208	9220019	8040411	12990637	12942550	17627098	21067988	17382704	17188953	4282425	13165139	21416487	18791330	4018601	13540671	14266246	18848884	17574895	17912443	16618728	23292612	12587810	11447465	15630503
Phosphocholine	414876176	196481967	244015896	431888755	618126073	386801219	199674142	309940065	537495528	446412262	327854909	514616942	556890237	332293256	483211988	537220374	544070482	333952940	434828166	564448338	438384879	364859160	345891616	439893689	475484699	249784989	394319883	14884918	372119670	309349163	236893327	487902263	359844218	362354971	103305898	88321297	467659562	54409398	377372349	489570299	446518641	390281986	86492045	577311587	552866151	401684298	353510114	448623795	490866145	434375132	354431785	508485267	408583587	250703217	218266504	126967187	434848660	310936796	374171752	517873241	559397433	436510548	428662377	594076930	486607472	193403346	331755799	411361805	390506459	328290461	356112900	471966528	578999462	474489838	356614493	601824827	421478871	213573694	252335411	212453666	475347459	67992897	356824282	510330844	579362932	521621432	536801799	564619200	385723811	327352241	328286168	507372491
Pyroglutamic acid	1827735	745412	1191816	2460939	2586617	3105142	815444	1986559	2031363	2141079	2578789	5046204	4043266	5642197	4132136	3757140	3075084	3134208	2694901	3018218	1914151	2170324	3612135	3664806	3703264	4059920	6941470	4041259	9290341	3354005	2478826	3826305	4307571	4549721	2208311	4221572	3813117	3329123	3866113	3730453	2725086	4548839	445837	8172567	5278067	5085335	4779449	2330373	2846848	5961459	3544736	2138678	2141651	1904131	1520786	1907980	2510942	4489116	3249515	3314969	5097521	3006553	1807668	3690595	4960207	1992449	1673847	2561922	1115311	1624122	1983324	2528083	1955707	4409074	5642851	4781542	2165538	1270987	2563170	3107753	3478854	560834	2336420	2104855	4587591	2834427	3879678	3535236	6227114	1062961	1793574	3452708
Serine	2562130	1953449	2037628	2759990	3086876	4127655	1814591	2244465	3022831	3293926	3732907	3639771	3695161	5023997	3447081	3170503	3291504	3286170	3433265	3607134	2442960	3053565	3680844	3462516	3423590	4589455	5301709	4972477	6385233	3423164	3081423	3728910	3873321	3918830	3372323	5071059	3430973	4077023	3472310	3868943	3777133	3981225	2240109	5685489	4605257	5039626	3862612	3047664	2509980	2830578	3193361	2603697	2897895	2601951	2824451	2675961	2808068	3543771	2306680	2969791	4589771	2938937	2695534	2873473	3241440	3488523	2850931	2652008	2233112	2493331	2773826	2754604	2249130	3061434	3386029	4200162	2805559	1728804	2730672	3676940	3075620	1359963	2907558	2834022	3401449	3219288	3482534	3098469	3801709	2604692	2688682	3378945
Spermine	1222407	446599	2222904	3030359	4203400	5226475	1020547	1128759	3362075	2161776	964130	5989016	3768563	3930157	4582658	2080870	4372031	3883628	1753445	3557749	2492969	2458338	5050575	4927451	5395789	3702781	7696071	3622038	10005300	5442644	4279276	5496222	5224671	6147951	5652032	3682051	4836327	462549	3972481	4581953	4103684	6908638	471588	6675189	6085992	6809278	5475719	4386304	3551646	7864485	5933064	3900979	4843887	3814180	2174244	2906083	4786134	4683254	4702899	6222645	5310437	8429149	4064884	4855707	4707359	1878401	5120384	4941430	2099595	3847711	5270850	6814896	3426150	7215771	6211965	5000752	3851490	2629038	4950503	4696430	5649274	316154	5094679	4963361	5892877	5134652	6667592	6641806	9041756	4066636	4311008	6519568
Taurine	18599267	11407881	20714896	30410355	35505748	43888553	17496682	19904849	34093706	26232053	30512720	45189557	37798076	49299430	42543745	46721782	38035777	44456264	34263163	38694363	29267544	31152453	42020978	42711394	32888758	30435524	47476768	36335263	61284113	35898076	30621832	46400558	44010267	45245331	36057218	34845845	30498708	36717173	32621803	40626554	45110152	44852642	15652587	46687820	45616590	60732301	41962796	25445398	23168540	34357475	30958292	36030794	40583503	29793563	28785809	34467734	38103679	36347843	33241549	33702766	42424370	40156625	36491461	33801913	37635672	27853837	36475569	35650213	22284759	26676096	35432762	33026094	23951945	37955412	42819383	42736067	28703392	19447878	35542620	43598110	35925215	8948826	37247907	29933381	41582968	34829967	44307205	40520035	40524551	26825511	33736398	35316348
Thiamine	384464	193050	319245	483513	678358	1477572	319541	326173	562460	656193	961358	1130833	1046991	4102248	1226691	458457	565904	637782	385785	739589	643118	531216	1798059	1317712	1086491	3304839	2426327	6086832	4693196	2098428	2168089	1909553	2446285	2689361	5984611	5974584	1340103	4487799	1866788	1714069	1510401	2102906	2163701	1478546	1693355	3283261	1540045	1232832	635238	1390618	2502212	866459	1154221	1507512	1961458	1001356	1002567	1994096	1352732	962389	902302	945884	1198385	989584	1496654	3441538	1223252	1108503	815383	838852	1256859	905700	754300	1755689	3223353	480571	1732543	643095	3033708	4499819	1402275	615382	1314387	963051	1002724	1091163	1280144	1093148	3266370	1137364	1452687	1331432
Threonic acid	1067345	215691	1089974	1195249	2224927	2772680	2317356	1148555	1181421	1933877	4482528	2003040	2732611	6105300	1597179	983376	880148	735321	1579741	2398069	1331862	2103274	5949177	2549439	1544267	2651153	1918976	2674922	7332723	3858852	2939520	3569700	2182640	4720444	3781971	5673128	1610184	4606364	851906	3290968	2003984	3090965	2212956	2810593	2363171	8167619	2020364	1932123	935710	1532244	3238046	1324394	2548051	1334589	6171333	2985455	2053340	2462910	2026309	1395268	1346480	1640542	3268481	2387075	3647637	6594992	4654729	1431065	1515041	1658339	3584318	1029290	1318853	2179930	3527377	583220	2023867	1298928	5109618	4263916	2566163	1202407	3358442	1614723	1699588	2199757	3386186	2363721	3467377	2093211	3378843	3834294
Tryptophan	105593	41961	59582	113195	152200	133996	53359	72503	128102	134050	131900	157099	159075	237332	150230	119207	107125	119226	101320	148583	90637	89784	143839	168345	167269	203925	206637	268108	296932	131401	106699	254780	175555	181279	126664	257153	149093	186509	116240	206112	191676	161361	63988	259036	239469	230598	164537	139301	118056	129103	119555	126763	113438	82551	95825	142361	119408	153001	121562	143713	221929	136002	143393	168342	170007	122056	109703	154861	114725	91897	132705	144184	138405	187013	207192	214373	191199	68942	136007	207721	211456	37054	141086	136278	199588	181822	196722	195021	247724	121942	129286	171509
Tyrosine	4462545	1747313	2516783	6002939	7618572	7547857	2749507	4007407	7534669	6191452	6411042	7461689	8825527	13105620	7932827	6047787	5866032	5714981	6564472	6886966	4697562	5009275	6950627	8325817	8308081	9352612	9366905	10919242	14106262	6731575	5371943	10641870	8770871	10291812	6649245	12138871	7494824	9662022	6532086	10466663	9104970	8640577	3497966	11378222	12114922	12930438	7537224	6427784	6197387	7033119	6966226	6402426	6518064	4844184	5496129	7595771	7376667	8387147	7042605	8069341	8798656	7245518	6956434	7818490	8616675	6418261	5500580	6787275	5671693	5084518	6492601	6876796	6188237	8956291	9553963	7409665	8157895	3319389	6115406	8536113	8304849	1788592	6829837	6374052	8661801	8805696	9150919	8669053	10862506	6603329	6563061	8259115
Uracil	1015912	220186	544078	1161414	975800	1216313	544297	1942338	1121453	1588139	1605801	1368534	1708699	2455533	1597842	1974477	1161616	1663648	2333487	1397907	1202850	1228055	1825440	1330934	1697291	1450831	4343302	2242274	1591168	923429	1066753	2142830	1730411	1830192	981068	1497211	1536253	1510066	1246956	1411431	1183697	1460853	239431	5125073	2745736	2792039	2120274	1333871	3043647	4437075	812609	976203	980719	716816	1044893	1083107	1187325	1158223	1797728	2159129	6528817	1177319	1058681	3492481	2989423	1223458	1033036	1503034	948199	803006	1336329	1302853	1170356	1387226	1644102	3489370	1624088	820650	1494076	1609756	1782481	474700	1343168	1180020	2444856	1284370	1763412	1735363	1910934	818738	1103839	2327004
Uridine	4541907	2206691	3689346	6463264	7898626	12231722	3275153	3231933	6810918	6197112	6788826	13868242	11890459	14146442	13947566	7925626	7091657	8278692	7257829	9012979	5669428	6989815	9225278	8166217	6816335	9120155	7465609	9900054	17720718	10010981	8187377	9566379	10182123	13614584	10674947	11705121	10027907	9637678	9260520	12416622	10198455	12703525	4483138	9340715	13914597	12180193	11211198	7846263	5709385	8580051	10281494	7752202	8012454	10379098	5789627	6347253	6676885	12413490	8300594	5959016	5025559	8618741	8221908	8368169	9386005	7438920	8080305	7002621	5299720	6066086	8029602	6993808	7763969	16306703	14347836	6892920	8425565	4822640	10200253	12306335	9822681	2217541	9100944	8637761	14636908	9691153	11369490	10367241	19313326	7630603	7622442	7827650
Xanthine	801756	307077	397642	1006208	994138	1117203	250271	406353	1005490	1010447	1005780	1026256	1502768	1224645	956770	1595408	868695	982983	1234989	1187041	758783	923713	1401567	1266104	1320772	1347482	2422901	1531125	1970550	1218216	894435	1465587	1907743	1546077	512512	1237489	1592231	1421341	1552961	1332403	1489055	1624941	302136	1935522	1847953	1887636	1886119	1320051	2131047	1959254	951251	1063818	710367	530295	626892	541704	705772	839634	575720	1095182	2929687	1112875	745116	1945240	1565806	608240	925968	1027545	767992	719690	926622	1150825	1128300	1292124	1486972	2565640	1602369	581695	1280803	1387079	1293980	349204	1225236	1216682	2075365	1530696	1766632	1851292	1959823	1349713	926861	1125053
y-Aminobutyric acid	77134792	38307470	71939673	95547196	105532959	88242424	48636731	76985525	94072276	70415292	72297975	121170157	119360024	130056972	111405376	112372470	98915099	55451365	99408995	110964436	80410742	93147584	125179924	161615045	125557376	106224089	139606869	114048864	264672766	104319105	110674879	154178383	114273215	127973079	92821203	110173763	90092841	90851648	101180538	110335978	118300770	129307759	32681849	145982998	152267970	149063613	152400681	97558034	98888628	120130648	86329918	108948629	96771896	77029535	71318625	85495844	104341181	96924193	95434652	126270038	141036672	120655150	87269963	114837522	92979878	92692802	87018072	98025049	69435616	72607249	88903102	106481819	88042971	119399526	126615108	134414329	91792737	68780732	126377733	109180877	132164380	41116370	109058908	51524605	141847493	126309905	135023424	134313791	148647528	84570661	96715886	136541466
12,13-DHOME	116783	290512	110324	212779	201068	175651	186192	64659	281087	604702	3527421	13132261	201519	103523	1482859	172243	167478	219711	108450	130977	178375	480603	4204695	19856878	203619	171257	150799	177622	95495	190717	2722336	99374	109727	354496	2935306	33412064	178034	118387	155460	192705	193708	190540	179836	174552	145432	724598	2745154	30084589	122016	161382	193187	185873	214488	149102	204948	193815	58123	434424	3088507	23631513	175280	188423	91415	110607	63888	178482	77127	157227	155062	478567	3335769	24494290	2057513	155366	82398	1934008	149979	166744	174146	213236	132904	934032	3433732	25505321	127729	208595	115990	222215	133730	167191	100075	129760
2-(hydroxymethyl)butanoic acid/2-Ethylhydracrylic acid	101400	24564	54176	69372	127967	70906	35259	72877	87923	113015	192602	71411	94156	219530	63315	54582	74435	67891	78522	158012	109370	75030	193807	127760	88520	105659	53678	167784	194345	81321	89709	197709	66112	112595	88754	199839	69856	195281	36865	118366	121504	51969	77077	80683	97510	199673	67762	130236	48989	41898	94564	109397	123888	47308	216988	146354	76715	57791	73275	74443	55549	77423	143581	77793	79682	250490	92653	51632	76005	60142	111636	68235	93133	84571	130986	54619	144051	40473	60340	193268	128522	76631	101820	98128	48720	114606	126226	87173	118402	84780	125705	149503
2-Aminoadipic acid	39254	23382	42437	60729	74260	89232	31029	25931	78852	47592	59615	81627	79826	136324	88290	46216	55204	61655	54879	73848	35952	48587	69183	89619	79822	65023	55166	67997	121391	64976	49488	109052	54382	79073	72710	99263	37022	49551	44989	85291	88193	78437	22991	54154	105923	164957	88524	58999	39818	50705	41816	56099	50072	37490	61801	71809	65087	58109	50095	65075	36366	49487	67754	78686	76895	46579	56841	62787	43093	48905	77363	85193	63046	94880	87678	71652	73024	44593	52642	52437	65634	12629	55382	40747	70464	56268	77159	74275	74496	41794	54063	66135
2'-Deoxycytidine	75983	34915	71997	86369	99465	323794	48719	56312	94013	118907	170900	65598	200348	643809	205772	144774	98667	71162	72976	128075	69685	54995	138339	171819	127451	381722	433167	565565	680972	251451	245062	153513	212106	276929	709888	686372	138676	432586	179890	219850	155870	325324	188259	366523	274448	251920	122772	93984	40761	226573	377658	93390	137359	123461	143907	116239	98531	470974	101783	139939	49581	108721	135682	109295	208635	300147	101160	153837	97916	88505	106987	132072	97298	225533	468838	187095	172601	48553	261576	536230	149222	43242	111587	89322	101856	111671	162234	147004	473317	82453	105338	138822
2-Oxoglutaric acid	7914	8359	6939	3820	10286	116569	3407	4573	10815	11966	19650	135614	88694	46565	33337	33132	6785	32920	56386	25583	9654	25114	30593	18351	7005	48542	7785	24407	34779	40436	28448	40304	6683	23208	53237	19048	32980	13652	6916	45126	16405	87185	9627	58104	38630	28565	43860	26694	27408	43747	80023	3452	9563	76365	29361	15046	6988	81389	24478	65502	4763	3417	37343	77671	106954	5585	22016	12165	4788	15284	26649	4385	3364	102177	114815	3381	13248	19318	32284	97072	8805	5811	38202	19160	36885	9321	41171	4588	158146	25534	22093	42713
3-hydroxy-4,5-dimethyl-3(5H)-furanone	173367	93292	123498	161953	221229	223392	98779	101834	144747	184787	186830	460046	228383	282974	227419	191535	229809	180765	175773	232221	163043	150415	176426	219700	212554	132015	285391	124511	395036	125654	137082	199576	217386	162513	192069	257232	175875	170489	193331	189549	185725	127059	117076	163443	169543	204471	139469	141671	113755	190963	245295	92027	153759	234538	171040	130139	137486	398136	145524	154712	82147	136910	133549	188241	236281	172865	106086	164907	95753	114302	119633	153536	96072	298128	235325	149943	115109	70994	112510	114511	106873	62965	92328	115918	127542	124332	132643	144484	252681	84321	100712	158466
5-Hydroxymethyl-2-furaldehyde	306466	387509	264845	518656	921145	455161	81633	271369	945020	317335	307460	343453	742404	335083	40983	394202	950274	416598	497532	566227	630386	424166	784637	1142647	1167522	589881	880171	383633	334085	172707	317394	754850	918425	324660	228817	720405	189058	580029	161767	226839	916433	217241	223093	461888	65482	375945	505545	472524	648114	858729	887314	925012	961828	273001	334745	479264	973825	75871	80243	1181249	606526	1212985	387299	1159809	1381667	270403	330146	528566	543614	521220	457454	1046018	349889	116393	514215	837080	464175	304786	508559	627361	442836	70968	416259	84962	122488	1080856	708599	932090	211395	427712	282867	679403
5-Methylcytosine	25157	9294	17673	16950	27673	29730	4963	18555	22532	50262	117510	23409	24071	73105	24845	22251	21245	55832	674096	72858	43052	56616	134393	50554	51460	39229	30522	55858	116661	44446	45731	80509	36570	73116	68384	67919	19114	143107	81362	60170	47408	27962	65775	18641	35473	105540	41228	68722	6987	13911	25018	26532	51775	22955	83031	34745	22676	39722	34016	23752	10033	24374	48603	12499	23212	96873	54763	21867	27446	36464	58016	24079	23100	36398	48604	7478	53388	27280	62740	80357	53380	35050	62372	38739	24615	46187	61532	32791	50060	46536	60069	84403
8-Aminooctanoic acid/Propranolol	176632	76767	125634	123961	224818	120026	90794	96088	135827	211939	259590	184516	203703	303630	149984	151119	152009	175204	281833	202873	125305	106777	208731	223740	136299	146768	162212	203695	312058	131298	123340	284504	187473	212485	187559	223444	118234	323700	135384	250574	217029	122979	131136	180456	187669	314437	165877	175384	102753	117637	111676	137940	218053	89979	262492	194381	176053	124985	153912	171689	138134	134628	167479	131240	164130	283951	116233	130696	118352	104743	113393	101016	141159	126628	157287	138924	200628	55067	119950	210487	220612	78705	121593	103602	109487	143941	194203	163889	146243	107334	138129	211813
Acetylcholine	173806	43330	133115	74824	272712	44377	145848	53680	128683	226104	812161	655	7052	9300	5355	32833	99104	564601	2603376	376610	180078	351496	213805	40625	33460	7755	1683	4566	15692	54242	45194	13011	35176	106286	43765	2949	9206	48613	1896	6485	2387	90817	112425	11202	958	168612	96972	1761	8352	4436	9302	19910	30481	1010222	724812	13915	22620	21685	65311	18967	4792	40459	7709	101011	6765	664820	970157	24538	19819	135145	1033293	52940	20827	12032	3986	34370	21302	256213	473121	8358	8921	435577	202337	9350	15930	16578	16258	27474	6079	291419	174446	12490
Acetylhistidine	380911	52865	47814	70369	168414	53655	28541	45211	133519	71127	91507	91095	82504	308076	119302	566809	55498	64991	80173	129668	157488	63024	67336	95730	149671	59736	60332	60093	102404	52923	53485	60772	77517	61506	48968	69994	338223	163061	71363	80797	60370	59039	32366	92701	88499	80253	105086	70215	208473	47198	45170	67261	62854	83499	68067	85783	98820	51374	73343	66495	160947	44481	58846	50373	41988	128818	46507	276339	55823	602684	52584	177596	154793	67021	61453	60655	57160	32849	51565	56021	400956	54230	45577	102429	73338	60030	67274	61658	60302	87785	49679	51408
Adenine	5342222	3636644	7130161	13473045	21271730	24098434	8735839	11051311	23597580	27640218	34475788	25779790	32020988	19786094	15963464	26158718	21010818	36452576	68026632	17478488	27408738	19766336	34554208	15940695	15746137	7599694	13592602	12580053	19299360	11700453	12821381	28730262	17823026	19331720	22706404	14479696	4438169	22326988	16395659	13168150	15647101	14053531	13273504	14266089	25564398	31415154	35380452	35850888	5380326	27861464	26073266	27384842	34182020	24588576	31019176	25208928	26523374	26381306	18442878	15962145	12787188	35806060	36458992	16482461	20631672	27450100	31614102	29556912	24598242	24773636	28032070	24685924	22549944	21119178	35826288	21835366	38287548	13511152	37450616	44479896	24212476	11628336	38199232	34982552	22194812	37699880	11418075	18658276	42891156	40055788	33509404	19603094
Alanine	1868820	1286200	1881665	2852812	3033325	4389499	1578302	1974295	3192986	2631658	2831138	6210120	4963710	5468001	4364925	3787468	3173039	3667967	3180128	3819539	2458316	2628380	3500773	3768670	3742449	4452651	5521463	4738737	7716812	3416687	2851572	4477319	3636110	4279550	3668640	4891676	4098829	4055033	3365724	4622599	3462490	4141672	1447335	8143842	7270553	6157638	4453904	3122963	4869692	4420952	4566331	3119345	3379461	3230560	2790237	3140461	3250666	4280861	4023053	3339989	5636905	3600634	3137402	5922057	5473974	2734844	2804496	3399460	2306903	2537183	3424170	3236145	2779432	5862387	5112945	3498912	3055262	1748888	3431436	4997283	4011491	1233365	3299448	3755445	6233490	3574873	4203838	3654915	6401668	2267963	3072092	3407246
Anserine	160625	70629	149822	198173	254530	273128	112145	150643	223915	188594	183607	273899	253286	376756	275737	242493	201381	226896	164926	195693	188420	175495	293670	330892	232863	265969	321130	295392	598875	259233	237592	330970	252214	290012	262751	258174	209036	213435	211863	239523	263012	277044	105263	422216	325592	409835	210509	166519	161119	240913	181579	195585	255276	192714	185469	213772	242555	264343	262864	275775	312405	250999	225280	227148	229331	245407	179553	191088	151705	158413	192692	235786	186362	246740	295322	345309	207133	128802	255719	230166	316835	65080	232803	133940	271336	256426	290696	285947	262580	189233	200432	301135
Asparagine	700189	568329	548103	795261	889427	1191217	557568	611334	804231	979644	1025085	917366	1097801	1629857	962731	867836	951635	991124	1184969	1162346	750836	932662	1291426	1023951	979631	1759255	2042353	2526479	1896703	958020	962488	1202683	1156166	1288453	1219037	2222846	1175315	1939763	1100997	1281439	1084896	1206329	894806	1941781	1470482	1431490	1088103	924681	824780	880171	1021891	759719	821375	801319	928807	793556	852376	1141858	904700	882980	1456124	901661	800305	889883	1062312	1171665	876442	790687	793190	755193	795087	785237	692432	893343	1172567	1320754	993168	543595	929656	1475097	1002466	634468	884893	859104	1086597	1001322	1095864	1002297	1373913	938147	864869	993857
Aspartic acid	5231301	2072687	4280547	6002081	7586293	10041563	3345364	6357415	6093395	6700481	6203738	7946351	7182153	10264698	8645422	7556510	10395326	9545771	9920954	8969958	5917835	7400491	12110601	9106896	7460999	10372171	24670146	9226939	14490616	6646008	5924914	11200697	10538922	9167738	8706150	8468503	12021761	7012139	11809850	8402487	9775646	12093659	2826010	23899756	14956136	12119050	9661676	6545599	5207366	7040498	5977110	7069671	7080575	6913403	5869210	7308175	7666208	9503906	8913095	8858123	18446132	7875383	5682105	6345115	8755029	9124435	7189582	6817985	4986525	5143339	5717209	6539950	5129376	6155356	8020098	17604208	7547873	3787249	6610309	7779633	9005391	2127795	6184179	5333501	7843138	7949251	10795509	9734757	8815565	5801120	6523232	10331866
Benzaldehyde	133894	160315	186998	210123	401931	222873	180956	182587	190434	240151	268385	123262	192329	593048	258628	212082	269160	229433	244214	465117	222031	199416	317823	137422	178670	232822	310297	379609	625524	313716	304434	555197	243101	268227	238830	281516	231460	474905	272559	390071	329087	265472	236831	283758	279555	577330	274621	275449	196727	356553	405529	408615	420491	294004	598697	569270	306991	313847	238949	207799	200821	214846	684800	373251	418476	641532	307948	251088	241145	280003	262367	199278	155612	167311	263040	213482	312058	221055	442610	438856	251654	241883	178738	181811	161730	192923	251752	189071	194615	280997	264617	333993
Betaine	18118552	9806714	15133461	13296409	17910010	13915448	6634050	11799609	15249551	16825766	29472368	12394924	14934304	16278935	12624493	16769826	12488608	17962660	106462432	19167010	14674628	14435855	20393130	21481762	22607134	11574689	16255602	12764128	17189104	12302574	13581336	18654894	15003105	15333454	17378950	13923906	12460613	20008912	19864116	17676706	18715712	12935708	12829133	19427234	18851718	20155282	16594992	19715434	10683555	11180474	11946464	14439639	19825588	11608023	20940250	18979812	17048226	13390248	17442158	15952814	16941234	14686041	18473480	12544394	12166159	17495794	15176505	13151712	14408756	11475468	14302917	12229003	12216460	11626009	12021430	16936090	14271236	8621685	12616067	13009567	15368157	8002284	13083380	12546917	14215323	14222334	14116587	14041564	13138180	13180453	13195423	16894062
Butylated hydroxyanisole	3355378	1708198	2339411	2917982	4989412	2823727	1694388	2997047	5704980	4457645	5999461	2989732	2563273	6503837	4107535	2579756	2593213	3265888	4920948	7131091	6202323	3292170	4732941	3688344	3834356	2406996	1212227	2518521	4677751	3116182	2680186	7310834	2593700	4058161	2427014	3850820	1910422	5066370	1658543	1462851	4194680	2716120	3221554	2483743	3625043	6146694	3291765	11501943	1453057	2121278	3781446	4707350	4662264	1568473	6168473	10168120	3530821	1075581	3194038	4099747	1902685	4565025	6530102	3553006	4156859	7453859	5084994	2636796	4308579	2865028	5795365	2822966	3054683	3650154	3783539	1905861	1824497	4148453	3133172	4786949	3694144	2074501	4510487	3325156	3486490	5452988	6655612	4998994	4374250	4066150	3054062	9906271
Butyrylcarnitine	43416	41468	86537	102701	120242	104336	44458	53667	89084	74264	68157	109812	74743	101027	121320	104210	220693	301064	176338	230079	108925	230783	560266	123974	49165	37172	138133	79682	367905	78017	52346	242035	77894	86585	117166	107969	89990	88450	90255	128253	133333	118736	334877	90486	156036	163389	114559	109189	27114	104365	100173	346378	199819	174594	80122	96744	108345	105408	74816	86244	93376	127391	151624	230085	240935	264297	266229	115124	107214	98235	112115	141883	57158	122559	109043	121409	91870	98257	99294	98187	132546	30340	90104	67391	118247	156299	227419	235081	117900	131668	104409	171380
CDP-choline	102865	56968	121080	151592	236623	103892	103816	103294	214576	114973	154571	103177	73143	83291	45877	190905	271984	268621	269012	289547	176307	229289	282186	203935	163581	3330	12513	673	2822	85317	30700	267874	137759	30513	4099	17914	39792	104830	48443	22998	173757	93425	29720	15362	43463	267906	205819	178284	63807	78892	2616	234781	223473	60465	183682	141930	193122	24405	37938	164468	83684	224716	220912	81796	25894	148696	234427	154558	100587	166467	199890	168393	110660	26492	14953	247453	123409	121749	148718	91910	175395	55352	182290	66020	77430	190404	207266	243757	2716	180321	234227	237444
CDP-ethanolamine	53167	37995	73409	86549	124802	80138	50836	62052	102466	74590	101273	83733	60475	63630	29117	114991	136997	152396	128622	108920	99190	110173	137825	126204	97187	7847	67406	13262	12215	46195	29922	137775	106064	28642	10433	13742	32728	44072	47829	24220	115468	79308	27145	56647	35926	156040	139064	93252	84475	61281	37152	121907	125934	43147	110688	113130	124929	32959	35519	112122	89116	122553	111167	83522	65979	57155	117015	98477	57636	85719	112723	99980	59770	24417	41740	112636	67780	64036	90823	49205	95254	22920	109051	35680	43990	96463	123820	126235	19585	92973	112727	124639
cis-Aconitic acid	17647	88721	23393	167530	458844	144329	5899	53275	567614	32718	9646	302543	192290	13412	58950	276589	811669	119666	93386	76647	221687	50618	49425	472460	586253	65374	401707	47109	50846	10403	8170	286081	455129	17874	11142	12467	84656	6246	140824	12744	517245	68339	548	206356	75352	75334	83125	137293	343181	515739	186253	712207	675094	113826	4939	44572	526566	21056	57289	850542	732033	867669	82096	527107	480106	1031	32128	435324	67637	153324	65724	726669	89002	76247	97228	1116066	96264	76045	7052	30140	206629	2648	81032	55436	178602	468765	331525	406876	41913	70076	64016	158372
Creatinine	96448	45111	92859	103621	139801	138893	61260	101185	133445	107776	129753	164526	138433	204093	156200	174688	139318	183543	137104	160302	114040	118267	174311	173353	143100	140471	177114	162743	306230	141599	112271	209426	174733	181916	159084	173565	114638	130148	128604	169427	184131	162428	59696	242743	210865	245131	182156	126215	96583	124346	112789	152131	156440	110262	123766	162633	145016	134395	153423	148576	202206	142776	155473	155880	161390	142826	128288	133053	91626	94774	139147	130631	108773	152456	171487	189917	119147	71342	144177	158696	192252	39414	138006	112896	167596	152705	169563	166427	172489	105453	132304	177101
Cystine	90738	7686	95754	137846	22764	349670	202132	129473	4421	88071	109026	4497	217270	444781	6726	3232	6156	223042	174972	66991	6825	111054	288515	154251	99726	457683	655183	838764	530858	923863	722716	164294	184504	431953	935890	492730	104178	252456	3547	211142	117162	837004	553117	598091	48612	405852	220632	70834	19095	388255	402113	2263	10261	21779	95658	19854	4004	504558	1418	22214	58610	38186	22509	129408	306060	303419	242300	397	13176	70917	262393	29885	1737	81737	404699	135732	44460	122202	968113	315355	13180	70934	170505	1773	5115	41993	195423	96723	259059	22242	118494	258737
Cytosine	212776	126561	199221	217068	267283	233672	136511	189106	223175	277037	365332	219528	191389	280895	199977	244836	225403	280008	2339358	275477	254522	264283	420041	279497	298411	178339	223695	249264	260269	202120	221451	292414	206611	225239	226641	263324	180999	383683	372668	266285	287207	205918	246595	224081	209003	312007	265071	333435	156355	181589	163404	225375	374365	174559	345615	251252	232586	195982	226617	216315	213031	212727	266491	224957	229021	302226	268738	215369	223166	206560	273237	231446	213673	210507	188077	213393	215549	177358	212083	263638	265021	209364	271416	192902	195972	256842	268159	260216	196141	230322	261316	280974
Fumaric acid	63061	28679	66502	63096	73784	157121	38032	65545	87327	76893	77681	67406	54146	49348	45602	74550	171492	152850	162930	136778	86649	128891	144403	153261	100210	69471	115622	68674	113555	86968	87888	210021	129697	132087	148750	79116	59431	109287	118150	62278	185253	153455	54146	229533	99493	211553	151877	104874	109487	85198	50176	57818	77645	118989	86878	55951	62440	35731	147280	83126	125054	84328	108373	168728	111556	92968	101024	69300	35421	85287	75785	66179	61454	77323	54007	107243	113629	57872	82784	89586	115978	24331	98218	89240	83454	133960	155254	107987	80911	101117	230960	148959
Glutaric acid/Ethylmalonic acid	235634	157847	192712	179709	363658	233877	120137	152421	215507	267312	371370	228917	257815	596529	258325	188350	223012	233508	191133	435108	248935	170556	426727	330229	216780	229402	204902	273383	482025	229757	185925	382487	241851	203234	208529	427286	148082	427671	180640	288691	329582	179270	165703	180528	260181	412185	197578	326244	181021	207634	288596	248370	305733	191813	387184	342659	219558	169858	164005	239930	156122	216140	563244	209160	262838	504998	202152	176192	168924	139817	211779	204824	216726	243085	328669	142446	252986	155907	226774	372611	241616	164363	161962	204672	183443	214447	304649	153515	218543	191424	219723	341289
Glutathione	75022	199052	199591	579670	645404	289497	131187	242998	1606410	154614	96199	424669	176130	66528	243191	427697	1901017	842583	1309473	229363	596016	598966	44152	153547	197172	40973	87466	37390	26991	33063	22997	297011	240329	33303	32605	25777	127557	31747	240109	99165	380337	242935	10056	197133	306510	44902	231632	433250	225748	255795	159024	3443237	2509735	429274	36742	455179	1337363	282263	778191	1918865	279021	2114443	761351	228467	172649	12340	147730	907327	496667	1212008	356839	1667395	399529	449517	163708	1991201	456874	526303	30684	125725	577821	14201	490241	648930	364271	597426	556270	1038409	271550	805879	388329	202831
Glycine	770175	515317	591101	777530	906478	1134419	559518	611499	784965	846367	843749	1048147	1107834	1452142	927284	879219	788716	921055	845810	948282	705391	827389	1048601	925245	934773	1213340	1378143	1467987	1883200	1142707	965210	968869	1121988	1305422	1197102	1372103	919863	1012667	912454	1005061	913384	1326771	765545	1539882	1222044	1341903	1181164	752204	669017	1137618	1086474	743958	728647	837192	615807	587063	726868	1071008	855691	815046	1024628	778868	786465	902623	980271	966867	707970	737309	531309	605388	851361	703653	702859	1112213	1323459	987394	784385	494481	1124028	1045225	993771	404471	814409	730083	1024530	870075	935134	863449	1350917	611736	700460	920248
Guanidoacetic acid	909035	295870	529595	606748	781880	791332	475080	469893	552182	497629	559393	752529	450471	525407	595620	1276439	587799	914800	84995	1022375	628028	725588	959187	764505	562875	463739	496884	552737	903550	532304	488271	755077	542253	689133	564282	595039	506345	373397	597404	463324	521686	557225	224069	651595	761546	733306	772098	507993	379601	449080	423319	613863	527462	472836	621800	987188	641987	699909	913068	655440	826383	684988	959486	584942	559521	887116	752164	843228	593670	535066	599753	448715	784121	465384	531125	595380	460897	349905	615595	483643	886170	193552	696596	634443	789715	692365	848510	718183	580811	565133	645190	1016016
Guanosine	840415	594379	1157665	1352280	2154012	2494080	930138	943977	1573504	1150835	1367970	2517446	1718846	2653541	2385026	1615593	1979172	1715762	1304768	1761684	1429663	1164558	1584817	2200280	1578744	1423812	1319892	1505984	3266947	1909838	1729339	2039700	1645822	1815345	2458562	1687399	1069517	1118817	1370034	1900689	1996122	2169788	1203156	1842144	2006353	2092264	1475657	1211228	229674	1207968	1842953	1704719	2057206	1926413	1473127	2023894	2028504	2181140	1977421	1754086	384847	1838785	1711237	1080922	1683472	1197033	1307607	1608140	1157987	1313381	1502083	1475643	1232431	2184405	2041569	711496	1144386	807215	1708745	1668499	1883238	315380	1492810	1257399	1535962	1477737	1726120	1751452	2005850	1003227	1589585	1524496
Hexose	50162971	38372931	29447828	38641488	60719089	40271813	25504530	33720398	55674523	54071309	50650885	47683311	45881438	52694457	50538488	47581526	49074786	48361620	51366114	61324432	52387605	52523305	53583628	47736595	44166039	39757869	26258652	44082649	58635065	38749795	39501151	55423901	43982194	45392171	30964661	47548847	39465052	36371060	44533176	49482905	50588374	43931598	34081998	43435363	46289374	46646689	51308350	59946417	42684229	34767013	40512540	51047456	44408941	41446457	40054766	43044836	41042700	35358960	43396216	38653306	42931176	50087764	50964830	58881110	48066954	54529293	45781646	41018334	49207064	43666366	42184998	47382296	52086354	50987165	49583086	43169541	43494605	32404669	42895657	37945236	53913782	26333756	48051454	45528648	46695909	50741928	43516969	33054048	50956527	47029150	42443549	48148993
Hydroxyphenyllactic acid	99667681	90979926	76954405	77534286	152142577	24265504	64151319	24599947	150260906	47211870	60532131	42583810	3194827	3152454	12117657	64050224	128462021	125133027	145155012	129994223	104499592	140774939	106707744	77640787	46604849	1248012	4779428	8306304	569806	2405548	1814479	121781707	76798059	6557156	448890	829318	6546196	494822	40605103	4316368	141266013	20035125	9312879	19540503	14742326	31572171	67631714	129668477	16158118	25879397	2085642	145693956	120109217	17082392	116635282	102288417	107887560	738485	69032560	64877974	16969271	150233035	202306836	3455011	1480342	1542483	188311153	156717045	112246466	138416956	84062019	93262021	79863284	1067206	534528	27808081	44016220	67441009	3496838	526987	92036135	38740069	86888323	46403153	4485150	139370028	80744109	89853864	503273	162296911	126777276	75940605
Imidazole	10064058	4416490	6023407	10800333	14845400	8337423	5424579	6028235	12755321	16314193	19636790	13845971	13072539	24429794	10695500	10381063	12087834	9243765	13514938	16686053	13969642	9776332	8584045	6748637	3120497	3740915	2392612	6711533	7338983	4005511	3963368	7217211	3335847	5533334	5597983	11108142	2439067	8215076	1669302	7670917	4719560	2267546	3881812	4459856	5147898	10658105	5237399	8099635	2372200	2305305	3735372	5635458	5943190	2409215	8204103	5174180	4094890	2928802	4314668	5331454	3064759	2526572	9589869	2756998	2886452	8375966	4502530	2370017	3896563	3699410	4856388	5044765	3656482	3919143	4663786	3202329	5150948	1455525	3632521	8112320	4466324	3582635	3431877	4281819	2952168	4009177	4705226	4201331	3624831	3673145	4763516	6021088
Isocitric acid	400251	4571442	574465	3489259	6141958	2278454	270907	1184451	9389557	487513	104153	4120233	2891384	106851	621175	4117720	7964022	1402824	606823	851118	4480747	1093760	418118	4911619	6561164	1131747	5896375	851667	216875	164151	129902	2900136	5272484	190925	133019	124173	1405527	110205	2340042	164791	5062606	844135	27884	1782665	724716	412371	1101975	2610797	8504059	9853787	3844542	7338277	8643617	3236115	87466	585558	8284258	303626	658597	7625792	6032121	6076846	1344117	8614267	6243663	22086	563162	6971576	1909749	3216549	1135591	8690903	2460014	1202229	1579250	418320	2286862	2566089	124459	347719	3153054	99428	1394729	1149575	2609117	6518814	4370201	6069049	583701	1795948	896708	1324024
Isoleucine	3358115	1258938	1821013	4359764	4814821	5210455	1358980	2427419	4175604	4384088	4662063	5459997	6607197	10721200	5091114	4270686	3596101	3081105	3935602	5236078	3104871	2678378	4720933	5785635	6378070	8541839	7749770	10307539	14333998	4742229	3867538	7173356	7032363	9053354	5174601	11871693	6173983	8941075	5209252	9428053	6824041	6147045	2506908	10203311	9571858	9937219	5199607	4513332	4898084	5343134	5230689	4206144	4399304	2402809	3722880	5050573	4444027	7309794	4245624	5571877	7429705	4540981	4149518	5572356	6306173	4776157	2988664	4194247	3793725	2684920	3637130	4169364	4456762	6128262	7433640	5790859	6177507	1888776	4050146	8004050	6717839	1375129	4047426	5032168	6888936	5960516	6048421	5528602	8565225	3857832	3654040	5490699
Isovalerylcarnitine	291147	259491	507993	327116	455699	591006	219365	224307	461535	402356	403033	403107	313836	433619	344510	189429	340096	391009	312097	420046	281738	351114	588608	595169	460595	392435	507869	525521	411655	487373	430292	424626	387387	496992	680704	476075	268236	350962	290442	288652	506284	423544	281010	505122	417036	506568	415975	401453	343915	381326	372969	499616	400302	374452	495106	604400	552029	441585	419259	442757	239524	496192	442524	478777	311705	468846	407143	411802	374994	312570	380434	408369	321934	473998	401682	382751	495321	237935	367135	346031	433453	132746	355130	347538	357162	469690	413553	377045	489423	372658	407212	371876
Kynurenine	33524	19747	29751	34513	53735	34800	25903	25653	31136	47647	51715	50372	38906	65236	38764	29272	38675	36231	23497	44315	38558	23342	31723	73729	57966	60212	39189	55639	71177	45721	41284	84247	45742	56518	40854	78325	30252	48840	39385	48218	46643	32828	17399	39064	35176	54353	29372	34958	17209	15447	32304	24905	35662	16724	44049	27457	24930	26197	23327	25790	34730	26534	39754	37980	42651	32266	40592	24768	35198	20323	26575	23160	23269	32758	40804	31653	47684	35390	34017	58848	45731	9631	28581	26023	31363	33686	45851	36556	38624	33174	31461	51152
Leucine	6793881	2321660	3345928	8376092	9315433	10826609	2656003	4925752	8022266	8645668	9057893	9988076	11931329	19731140	9498979	8020642	6825038	6173082	6714754	10262130	6015350	5601025	9316297	11533205	13446041	16482651	15590079	20506956	29062992	9840679	7826243	13962180	13939594	17194510	8960373	22903044	11106972	16328690	10255766	17557372	13556184	12692353	4821672	20043570	18607096	20601918	10773595	9142800	8901798	9855817	9172877	7979501	7967895	4839887	7338165	9000803	8204649	14088244	8412114	10596561	14231198	8615020	7956662	9993551	11172973	9026564	6214344	7707239	6953758	5192760	7191685	7690616	8363302	11247151	13665627	10722110	11998790	3788267	8167227	14608116	12665567	2718380	8247274	9255087	12302557	11523922	11652575	10827668	15621871	8432777	7312904	10532023
Maltotriose	53528	18023	25399	28662	58429	29941	7218	23730	44223	85922	138529	33948	43971	253535	38066	33941	30046	73378	2417030	91033	54511	28669	96759	121345	287984	51775	160626	87607	119735	25871	42581	90002	27098	46840	64581	67175	30872	159581	23607	76521	57848	16278	50061	31966	33227	52355	11431	57465	6986	8952	24930	29077	40242	8609	71417	44063	27944	14522	29848	14417	9452	16979	48422	21847	22917	71113	27238	11993	25740	17985	30056	20044	22361	19973	26908	9118	24884	6562	18051	41242	31606	23804	23277	20847	12618	22097	20582	17176	19944	22208	28014	40936
Mucic acid	35663	4618	24854	33858	75599	288669	20350	19405	48202	57450	11847	294988	212728	177530	197936	180884	63202	58723	117832	76516	73444	45972	1934	46629	35143	111279	289879	143405	269466	104526	73151	53761	58501	72637	103798	12415	157972	2430	112931	208525	50226	310998	1237	386105	275538	49664	69481	15066	85824	163219	92384	91892	53133	137173	605	8169	48125	151274	89238	42848	207110	50269	30620	130619	89124	2378	10027	65832	4681	25616	37150	48122	58768	202447	177806	98903	22627	15434	16173	89003	49241	318	46305	108594	218992	31311	48917	59668	232595	24492	38900	4987
N-Acetyl-alanine	227582	58246	97836	170996	293237	400857	87046	263167	245027	452995	307537	337730	419964	770180	299874	256384	155249	162700	204162	204198	155732	129120	257918	310783	287941	571078	818142	649499	838763	241985	180412	377912	373138	286823	303015	684569	359795	437349	375868	551190	311603	378829	62318	1090413	925181	691454	354498	267032	281039	275546	245089	200163	201422	182257	247972	259493	191303	561379	475035	345458	938641	234015	250316	263997	302114	339347	200684	239967	221684	115130	285654	192591	226417	328249	456897	617567	407789	99947	239794	451255	419189	109077	234620	351066	414284	246535	243630	240394	504599	154240	157233	262858
N-Acetyl-glucosamine	95374	57927	81634	110800	129081	206600	119972	108318	121313	145968	132221	139308	125597	154656	147455	154906	180125	102068	103616	125084	112296	92602	101452	100679	108788	134293	157168	317815	106555	155567	156674	117380	167859	182869	305552	197501	114981	218730	142885	118502	128199	187055	235037	110270	104419	148688	158526	138295	122224	212311	171328	169853	180188	206700	135750	186354	228116	149601	159113	228482	147417	194436	133717	120022	175416	209211	120046	259952	171136	170113	145986	180851	146713	129543	156620	177503	152942	91421	214903	185812	126185	77258	150882	159961	101782	147900	110073	152249	157238	171736	125788	134567
N-Acetyl-glutamic acid	70880	38781	74634	83133	104204	110357	49383	56170	97659	81594	118693	110968	103104	140871	109158	139330	131658	148090	121988	132938	85399	90097	142505	151987	119625	92035	102405	98112	205117	105610	87476	148130	118504	129011	109409	95136	79106	110580	86209	118690	123921	109117	42411	142809	129924	215362	141459	96158	78596	107774	102608	101555	131760	84384	120958	141203	130167	114990	122544	113106	133706	128097	108052	93934	110918	68096	99036	96510	64820	78908	103058	95964	65432	100938	99564	117592	96304	51598	99536	136540	116567	24493	101170	100571	128436	108247	143508	134401	140597	80580	110306	120371
N-Acetyl-glycine	177566	55606	104488	81598	170298	95261	39638	92593	94775	191978	385492	62440	120388	294109	90837	60214	77412	164021	142797	306684	147559	147607	447700	333815	184605	216973	50418	284132	362003	170843	194994	373877	190008	308270	220008	369388	98955	497575	50230	237052	235874	97643	227569	85613	129920	457549	163756	272515	18357	19270	73823	91125	138991	73692	370071	212267	92500	121214	88377	71012	22175	77903	215759	58573	81559	361070	179190	70430	152450	101806	177003	69159	106764	121611	182071	46672	247025	95508	211104	399917	258557	152699	206865	137354	70611	202707	252340	134673	194255	168499	240605	316069
N-acetyl-methionine	152780	54521	80326	249710	394501	49799	46989	114092	299895	216816	191886	46823	163561	846280	112591	277511	226866	150634	179088	265409	211905	130152	187781	339255	343312	114740	29807	725090	324106	41125	35864	389995	318546	40216	36290	901646	48029	562367	252269	410231	422110	56276	74210	52135	159093	579841	177181	282016	24581	27012	114112	297868	297316	11151	231248	370709	320000	80226	207127	343814	95150	266935	452604	88517	108593	240487	234957	285708	219768	200620	276465	237632	238192	30195	92927	232926	329994	83386	63719	412929	317837	45651	173414	287061	92967	272223	291709	301033	46885	179830	238795	297792
N-Acetylneuraminic acid	218286	117099	186315	301527	429151	396547	151834	225174	376322	324981	326428	485732	410664	509961	420715	414607	443890	422130	373984	437133	322029	311199	414969	416349	338356	302971	454107	346305	614666	331763	256538	482388	419412	413099	300115	359922	361123	314280	327585	394428	412965	440932	144393	524313	518037	549407	462721	361885	289628	393977	335340	349049	380270	277756	272491	357656	398150	327163	323662	410114	440164	444199	397728	387599	430288	308290	328670	362271	261728	274507	356740	397076	342920	433763	418760	465975	363038	172872	340589	390681	417565	94849	358428	329175	467689	410153	438282	431699	453559	294844	322145	437113
N-Acetyl-ornithine	232637	106537	187684	183869	289293	265052	100941	141928	240526	285920	1176705	975719	327140	771321	322510	306026	321016	381970	2157090	416065	226404	256582	382269	544783	569881	314399	412746	327498	728908	347193	294867	409616	311836	359994	348102	330226	263079	529242	433886	523140	385107	333864	203892	434259	423187	452282	401396	403381	293425	338725	307067	325826	430701	238623	374829	423760	296972	323573	323378	338773	368111	307919	293704	295383	269085	268035	229641	196418	158682	144924	222116	198528	175634	211143	220765	203450	196749	100298	193589	292393	261075	94918	186583	208118	282507	242313	295344	252400	318395	203399	225432	264363
Nicotinic acid	274345	99549	323791	164412	285285	334415	71860	153696	232359	379010	1145419	213706	230739	792190	232174	202442	172002	267154	4836840	420994	256602	175882	525201	424112	751963	273228	347314	417632	804837	210142	223820	451970	189635	274696	343927	367036	178508	1163248	1056191	1542870	467256	144658	298253	356088	520077	381692	275628	527181	152389	85582	177229	229973	384111	113801	535623	332451	192487	169385	216421	215343	156824	158612	408343	185367	192811	476817	188802	141667	200986	134176	221456	183253	205264	414283	276729	101545	255951	87643	193359	387560	298488	188544	181484	255397	191267	218105	249044	166351	234066	192033	239248	314623
O-Phosphorylethanolamine	1201142	694912	1296333	2126928	2658139	2688489	1525638	1196714	2198264	1299338	1170239	3103592	2314385	1447636	2594094	3089001	2926699	3295224	2538444	2326171	1703351	2080617	1945334	1940367	2163650	629276	2173350	30407	1946357	1600124	1195415	2124532	1498859	1890274	512933	261357	1799127	174953	1358529	2113537	2019473	2397705	294736	2371837	2863800	2125148	2827515	1505011	2007490	2672392	1630486	3071685	2597525	1847026	983685	2235764	2685434	2027982	1763150	2362812	2447363	2975509	2309942	2671418	2840797	568142	1920507	2199486	1327450	1686495	2156305	2389296	1792118	2361391	1890623	2285998	1251285	1413262	1617602	881035	1999934	285035	2193421	1812716	2968124	2351461	2725683	2863916	1769346	1547725	1558040	1851620
Ornithine	40331	15258	23873	54807	62227	65320	18129	35747	42657	52885	39599	55157	58159	77900	48943	47215	45290	39685	42891	46575	33433	31816	44044	62227	76712	83305	113764	106023	117031	55011	39954	78435	73997	71146	52144	95121	59438	66388	62657	72891	64157	66184	27254	133892	102611	105612	63103	53908	53021	57683	45902	45703	46011	30538	40646	52180	53173	78001	74736	68290	107672	58460	54602	56096	65016	57954	36021	47342	39545	32872	48194	47087	40858	48083	65918	81131	53053	26731	38331	62747	76047	16058	52769	45559	66875	67183	63783	69103	83660	54672	49080	77141
Phenylacetic acid	503600	271626	354917	539615	622064	641195	212442	305087	503548	605841	731643	421503	717835	850047	265261	327172	491014	498731	537728	564070	552927	484116	1289174	699042	1067561	485696	688392	531212	623706	329540	418413	664198	701153	386382	397910	949735	275641	657412	108798	433953	606098	397109	391319	443699	178751	669782	575356	515026	295598	715093	650843	347847	546627	201741	687622	357834	412229	154508	121933	733188	267320	720361	640645	519777	625875	869932	561739	230403	335395	389367	634441	618305	279241	290108	455041	358038	328881	207669	491972	545879	295619	181250	399769	146478	141944	548414	457273	558473	289345	347079	337002	711900
Phosphoenolpyruvic acid	51394	19169	45592	67217	65232	74793	32224	40217	55066	64146	67095	76964	88929	146431	74862	63972	59835	73255	56805	77551	55030	45300	88770	85421	72767	106071	86416	131710	143173	84539	75430	89488	105756	103872	98278	124631	75915	117371	82234	107091	82888	95824	75574	89380	104050	104163	72120	75586	52884	78420	104407	67759	61697	73115	72363	81817	71053	85887	71059	72282	74316	81210	72138	87154	88096	101619	65927	72738	59923	58636	63399	61201	57486	89830	117545	53482	76384	48189	99483	131098	88368	38754	76356	63208	90686	68434	88950	76683	120480	53450	79437	79278
Pipecolinic acid	1352243	485813	602076	1068817	1295551	1051909	467088	670394	1082478	1423929	1742352	1016859	1225809	1645418	1056286	937844	1078506	1092022	650668	1480638	1116466	886765	950257	77201	1004105	212787	592405	732431	1295625	551541	438070	848537	923269	647329	781597	908688	492132	592739	494373	946498	1073908	573662	140686	668887	976382	760186	877908	746758	295179	355137	488587	614903	744119	388160	640049	715434	568100	646165	669493	683631	480023	615933	567787	457963	541006	519692	469353	464734	439025	404554	606762	479884	443593	610209	791178	522447	614505	199898	370190	629651	737737	98139	444829	568730	592048	641326	765667	721593	932372	301563	478752	851033
Proline	28040812	11480362	16195772	37335245	37274908	43367285	15202612	25065144	37999777	39789881	41397126	48590798	56064439	81578494	46405528	39188453	34978197	34701683	39405655	43491690	27032928	28470741	41278944	45534123	51516295	64615689	64040021	74467822	93890265	37146016	29578194	53710981	52504334	56138697	31628335	76891931	50512934	54543847	41951075	69229109	52244801	48412129	16581768	78255610	74589479	81704156	49327193	37634691	48490896	50821766	48448390	35460948	36924708	23751377	31527475	39279412	37033307	48521489	37841171	45641715	64811046	38226149	37659015	49856641	54340311	35014946	31977821	35859081	29416875	27294068	38964660	36943545	36696766	49649399	57113039	48506996	46706591	20154110	37257981	54181748	49516094	12850179	38769205	38430654	59347156	44815345	51809939	46341856	63588513	31091992	32549190	44230740
Propionylcarnitine	61320	32220	62748	229321	337482	196086	184892	464830	339052	259002	207190	499158	263494	457827	536198	724707	1082627	1759898	848095	1088826	530734	970477	2260373	490668	217377	48663	102079	152350	163240	39168	59916	807803	170825	392090	122667	117972	307841	188626	105969	281382	206078	218187	175355	320455	901071	831995	927279	448150	264964	419477	412060	693634	540037	494332	280095	389092	466809	436336	622041	581708	493039	543246	484840	578567	507896	1222507	724672	595844	275020	319225	536719	637592	418809	620169	705135	1284861	560495	437426	723310	516970	1013426	185707	475103	364963	843157	572686	1337439	1025578	673999	401253	498755	1471045
Putrescine	473967	259220	597042	560971	739543	973902	434124	542007	731955	784663	562847	952201	644086	879790	883931	460597	748923	1060450	920317	578295	611924	779891	1145063	703689	824572	622225	1257405	637781	1400652	1752013	1180368	1139758	990740	1549757	1400047	860379	890158	337998	1101488	895473	549956	1358988	697173	1109519	987592	1489926	1061933	892035	671074	1237104	986187	660840	1240359	1172835	1406278	902330	1004171	1449566	1163753	1341203	810634	1117727	1228782	808231	965156	1603282	1551791	1105394	787763	1063610	1487894	1259192	721831	1353932	1327335	977034	797903	867399	1304555	952278	843623	323243	1246282	735973	921715	886984	899944	999283	1185184	1058840	1029652	1064892
Pyridoxal	296686	259829	561854	1121650	1057538	1973179	284613	825360	1237841	1159953	720725	675506	968841	3035280	624141	294713	1569644	822135	869881	490192	766081	636949	1213876	1541078	1111860	1011333	2728380	3062774	643772	491283	605749	1455202	3045294	712912	1755429	2318068	567815	1561892	873799	781022	1921275	2429438	849962	489529	623063	2693043	1845876	1573327	294199	2985794	2486841	1010410	1710008	585021	513540	713949	1406592	2524738	390797	1567479	503282	2590202	1134679	309403	557140	1266164	1202836	1423705	797343	1927821	1342189	1905271	766019	566672	2469448	2387726	1576494	998403	922902	2256951	1414260	355355	1946445	1035292	403476	1845895	1326636	1491735	1416962	1467805	1427846	1219329
Ribulose-5-phosphate	503989	309199	347069	226725	317584	164335	290170	269258	321942	366672	381944	83974	74790	130326	75973	442848	168916	263489	503662	248496	223637	364192	186049	270389	396125	46233	174840	10971	222580	69492	45154	148512	177653	150696	15459	38509	155370	24081	111782	183660	359170	126517	79000	472739	151853	249354	311880	188594	593761	253174	50495	290420	155487	83816	160231	198666	136923	86198	275977	694631	2383678	206845	294673	255609	178230	104264	423105	255188	153255	302341	357337	331189	308695	28220	49223	1449470	197254	237788	105578	65696	214740	38412	313214	166254	114571	256566	309335	388950	60622	375095	273179	427030
Sorbitol/Mannitol/Dulcitol	127131	53589	76681	117001	184643	150120	39533	72559	132565	192328	297660	150217	139325	482626	140269	125868	119379	155886	201470	212482	147398	123198	2688006	244774	166819	156186	106808	246808	312295	99078	139943	272013	144510	151722	125397	187009	105880	285078	81507	230908	187918	126573	123966	133628	148102	211419	128906	172747	70153	85406	107527	158931	169529	90525	685161	168339	118405	123335	110090	111067	90349	124732	227675	131247	146333	251723	138447	101854	89527	83965	153599	113013	96902	133160	150805	73086	125207	55567	114912	185470	124005	56862	107923	151652	103332	120271	138759	109202	137148	90695	121426	124010
Succinic acid	317682	141125	392342	92777	170855	139370	100866	63211	80595	152675	325057	117518	144027	339857	92551	139486	85081	293549	425595	318703	98616	249743	719011	649481	353242	211511	425845	162753	1423784	1217538	416185	204858	103656	159082	476501	412390	92775	361702	73865	211140	220348	118445	144201	2960	121332	525864	191008	143149	57963	39386	110784	128573	85164	108890	390116	171691	67800	73346	60735	70892	42059	50976	258775	72346	147935	515165	349374	63227	86077	61849	214233	64179	78428	75554	93713	43373	96336	95166	140729	158135	85018	132514	116523	82432	99462	68614	202058	92207	77368	108278	158987	208638
Threonine	310705	122765	215011	373643	450698	480875	152494	268871	413844	385811	353352	462242	493676	774365	396622	467091	379926	405372	383109	493922	303388	322351	546096	558755	532188	638408	710450	828360	1278917	441658	375396	601987	584560	674900	467529	864076	432683	597333	407295	700218	549971	564123	176186	886437	860566	955963	552906	369801	388429	436770	384583	382799	385983	249879	356152	394982	448950	481993	396565	502713	640847	406025	384849	462973	516355	383596	319781	382806	287566	253365	360378	377475	332467	516910	613222	543752	480986	175194	405733	591218	590540	98211	386127	368661	555754	499218	527027	507705	719718	319605	343958	512736
Valine/5-Amino valeric acid	28639	7397	15505	39480	41716	48860	9655	20169	35040	38059	39205	50488	57060	105926	37096	36062	36882	30528	35122	46851	29432	23860	48356	54259	63359	75288	66932	94405	163713	42921	33220	64930	61540	79057	44545	115066	49339	76561	43592	88112	70346	51641	18548	90757	83914	91102	51604	38325	43515	45957	44491	38070	35014	20332	32531	42618	36872	49798	31899	47414	65512	37462	38838	50452	52132	39391	25465	37883	31510	21059	34742	32789	34499	44447	61778	50454	50310	15224	35804	67580	61961	9689	31696	39514	58546	50932	50983	49883	75081	33017	28283	50999
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	HMDB_ID	KEGG_ID	PUBCHEM_ID
1-Methyl Adenosine	HMDB0003331	27476	C02494
3-Methylhistidine	HMDB0000479	64969	C01152
4-Guanidinobutyric acid	HMDB0003464	500	C01035
4-Hydroxybenzaldehyde	HMDB0011718	126	C00633
Acetylcarnitine	HMDB0000201	7045767	C02571
Adenosine	HMDB0000050	60961	C00212
Arginine	HMDB0000517	6322	C00062
Carnitine	HMDB0000062	10917	C00487
Carnosine	HMDB0000033	439224	C00386
Choline	HMDB0000097	305	C00114
Citrulline	HMDB0000904	9750	C00327
Creatine	HMDB0000064	586	C00300
Cytidine	HMDB0000089	6175	C00475
Glutamic acid	HMDB0000148	33032	C00025
Glutamine	HMDB0000641	5961	C00064
Glutathione oxidized	HMDB0003337	65359	C00127
Histidine	HMDB0000177	6274	C00135
Hypoxanthine	HMDB0000157	790	C00262
Inosine	HMDB0000195	6021	C00294
Lysine	HMDB0000182	5962	C00047
Malic acid	HMDB0000156	222656	C00149
Methionine	HMDB0000696	6137	C00073
Methionine sulfoxide	HMDB0002005	158980	C02989
N-Acetyl-arginine	HMDB0004620	67427	NA
N-Acetyl-aspartic acid	HMDB0000812	65065	C01042
N-Acetyl-glutamine	HMDB0006029	182230	NA
Nicotine amide	HMDB0001406	936	C00153
Pantothenic acid	HMDB0000210	6613	C00864
Phenylalanine	HMDB0000159	6140	C00079
Phosphocholine	HMDB0001565	1014	C00588
Pyroglutamic acid	HMDB0000267	7405	C01879
Serine	HMDB0000187	5951	C00065
Spermine	HMDB0001256	1103	C00750
Taurine	HMDB0000251	1123	C00245
Thiamine	HMDB0000235	1130	C00378
Threonic acid	HMDB0000943	5460407	C01620
Tryptophan	HMDB0000929	6305	C00078
Tyrosine	HMDB0000158	6057	C00082
Uracil	HMDB0000300	1174	C00106
Uridine	HMDB0000296	6029	C00299
Xanthine	HMDB0000292	1188	C00385
y-Aminobutyric acid	HMDB0000112	119	C00334
12,13-DHOME	HMDB0004705	25320870	C14829
2-(hydroxymethyl)butanoic acid/2-Ethylhydracrylic acid	NA	NA	NA
2-Aminoadipic acid	HMDB0000510	92136	C00956
2'-Deoxycytidine	HMDB0000014	13711	C00881
2-Oxoglutaric acid	HMDB0000208	51	C00026
3-hydroxy-4,5-dimethyl-3(5H)-furanone	HMDB0031306	62835	NA
5-Hydroxymethyl-2-furaldehyde	HMDB0034355	237332	C11101
5-Methylcytosine	HMDB0002894	65040	C02376
8-Aminooctanoic acid/Propranolol	NA	NA	NA
Acetylcholine	HMDB0000895	187	C01996
Acetylhistidine	HMDB0032055	75619	C02997
Adenine	HMDB0000034	190	C00147
Alanine	HMDB0000161	5950	C00041
Anserine	HMDB0000194	112072	C01262
Asparagine	HMDB0000168	6267	C00152
Aspartic acid	HMDB0000191	5960	C00049
Benzaldehyde	HMDB0006115	240	C00261
Betaine	HMDB0000043	247	C00719
Butylated hydroxyanisole	HMDB0059925	8456	NA
Butyrylcarnitine	HMDB0002013	213144	C02862
CDP-choline	HMDB0001413	13805	C00307
CDP-ethanolamine	HMDB0001564	123727	C00570
cis-Aconitic acid	HMDB0000072	643757	C00417
Creatinine	HMDB0000562	588	C00791
Cystine	HMDB0000192	67678	C00491
Cytosine	HMDB0000630	597	C00380
Fumaric acid	HMDB0000134	444972	C00122
Glutaric acid/Ethylmalonic acid	NA	NA	NA
Glutathione	HMDB0000125	124886	C00051
Glycine	HMDB0000123	750	C00037
Guanidoacetic acid	HMDB0000128	763	C00581
Guanosine	HMDB0000133	6802	C00387
Hexose	NA	NA	NA
Hydroxyphenyllactic acid	HMDB0000755	9378	C03672
Imidazole	HMDB0001525	795	C01589
Isocitric acid	HMDB0000193	1198	C00311
Isoleucine	HMDB0000172	6306	C00407
Isovalerylcarnitine	HMDB0000688	6426851	NA
Kynurenine	HMDB0000684	161166	C00328
Leucine	HMDB0000687	6106	C00123
Maltotriose	HMDB0001262	439586	C01835
Mucic acid	HMDB0000639	3037582	C00879
N-Acetyl-alanine	HMDB0000766	88064	NA
N-Acetyl-glucosamine	HMDB0000215	439174	C00140
N-Acetyl-glutamic acid	HMDB0001138	70914	C00624
N-Acetyl-glycine	HMDB0000532	10972	NA
N-acetyl-methionine	HMDB0011745	448580	C02712
N-Acetylneuraminic acid	HMDB0000230	445063	C19910
N-Acetyl-ornithine	HMDB0003357	439232	C00437
Nicotinic acid	HMDB0001488	938	C00253
O-Phosphorylethanolamine	HMDB0000224	1015	C00346
Ornithine	HMDB0000214	6262	C00077
Phenylacetic acid	HMDB0000209	999	C07086
Phosphoenolpyruvic acid	HMDB0000263	1005	C00074
Pipecolinic acid	HMDB0000070	849	C00408
Proline	HMDB0000162	145742	C00148
Propionylcarnitine	HMDB0000824	188824	C03017
Putrescine	HMDB0001414	1045	C00134
Pyridoxal	HMDB0001545	1050	C00250
Ribulose-5-phosphate	HMDB0000618	439184	C00199
Sorbitol/Mannitol/Dulcitol	NA	NA	NA
Succinic acid	HMDB0000254	1110	C00042
Threonine	HMDB0000167	6288	C00188
Valine/5-Amino valeric acid	HMDB0240732	14274897	NA
METABOLITES_END
#END