#METABOLOMICS WORKBENCH yxw_524521_20240927_100018 DATATRACK_ID:5240 STUDY_ID:ST003538 ANALYSIS_ID:AN005810 PROJECT_ID:PR002177
VERSION             	1
CREATED_ON             	October 17, 2024, 10:59 pm
#PROJECT
PR:PROJECT_TITLE                 	Metabolomic analysis of fluorescent hairy roots overexpressing the Gretchen
PR:PROJECT_TITLE                 	Hagen 3 genes enhancing soybean resistance to cyst nematodes
PR:PROJECT_SUMMARY               	Soybean root samples were collected, target metabolites were extracted, standard
PR:PROJECT_SUMMARY               	curves were established, methodology verification was performed, LC-MS/MS
PR:PROJECT_SUMMARY               	metabolites were detected, and data were analyzed.Metabolome analysis was
PR:PROJECT_SUMMARY               	conducted on FHRs overexpressing these genes to investigate how plant hormones
PR:PROJECT_SUMMARY               	play a role in soybean resistance to SCN. These results provide a new framework
PR:PROJECT_SUMMARY               	for understanding the interaction between soybean and SCN.
PR:INSTITUTE                     	Shenyang Agricultural University
PR:LAST_NAME                     	yang
PR:FIRST_NAME                    	wen
PR:ADDRESS                       	College of Plant Protection
PR:EMAIL                         	2020200130@stu.syau.edu.cn
PR:PHONE                         	15702428682
#STUDY
ST:STUDY_TITLE                   	Metabolomic analysis of fluorescent hairy roots overexpressing the Gretchen
ST:STUDY_TITLE                   	Hagen 3_2 genes enhancing soybean resistance to cyst nematodes
ST:STUDY_SUMMARY                 	The Gretchen Hagen 3 genes maintain endogenous hormone homeostasis by
ST:STUDY_SUMMARY                 	conjugating excess hormones with amino acids. Herein, we identified the members
ST:STUDY_SUMMARY                 	of the GH3 family in soybeans and analyzed their phylogeny, gene duplication,
ST:STUDY_SUMMARY                 	structure, domains, conserved motifs, cis-elements in promoter regions for
ST:STUDY_SUMMARY                 	stress responses, and functional characteristics. We found that GH3 genes are
ST:STUDY_SUMMARY                 	induced by pathogens in Group-II. Furthermore, 8 out of 16 Group-II genes
ST:STUDY_SUMMARY                 	responded to cyst nematode infection. Through functional analysis of eight GmGH3
ST:STUDY_SUMMARY                 	genes via overexpression, they play a negative role in soybean resistance to
ST:STUDY_SUMMARY                 	cyst nematode. In addition, our metabolomic analysis showed that overexpression
ST:STUDY_SUMMARY                 	of Glyma.02G125600, Glyma.17G165500, and Glyma.13G284600 affected the content of
ST:STUDY_SUMMARY                 	salicylic acid and jasmonic acid. Our findings clarify the functional features
ST:STUDY_SUMMARY                 	of GH3 genes and reveal their involvement in plant hormone signaling pathways.
ST:STUDY_SUMMARY                 	This provides valuable insights into the complex molecular mechanisms underlying
ST:STUDY_SUMMARY                 	the interaction between soybeans and cyst nematode.
ST:INSTITUTE                     	Shenyang Agricultural University
ST:LAST_NAME                     	Yang
ST:FIRST_NAME                    	Xiaowen
ST:ADDRESS                       	College of Plant Protection
ST:EMAIL                         	2020200130@stu.syau.edu.cn
ST:PHONE                         	15702428682
#SUBJECT
SU:SUBJECT_TYPE                  	Plant
SU:SUBJECT_SPECIES               	Glycine max
SU:TAXONOMY_ID                   	3847
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	CK-1	Sample source:Plant root | Phenotype:control	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	CK-2	Sample source:Plant root | Phenotype:control	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	CK-3	Sample source:Plant root | Phenotype:control	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	CK-4	Sample source:Plant root | Phenotype:control	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	CK-5	Sample source:Plant root | Phenotype:control	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	CK-6	Sample source:Plant root | Phenotype:control	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	GH3_2-1	Sample source:Plant root | Phenotype:transgene	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	GH3_2-2	Sample source:Plant root | Phenotype:transgene	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	GH3_2-3	Sample source:Plant root | Phenotype:transgene	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	GH3_2-4	Sample source:Plant root | Phenotype:transgene	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	GH3_2-5	Sample source:Plant root | Phenotype:transgene	RAW_FILE_NAME(Raw file name)=-
SUBJECT_SAMPLE_FACTORS           	-	GH3_2-6	Sample source:Plant root | Phenotype:transgene	RAW_FILE_NAME(Raw file name)=-
#COLLECTION
CO:COLLECTION_SUMMARY            	Liquid nitrogen grinding samples, weighing a certain amount of samples into mass
CO:COLLECTION_SUMMARY            	spectrometry water, vortex mixing, as diluted samples; Take a dilution sample of
CO:COLLECTION_SUMMARY            	100μL and add 400 μL precipitator (acetonitrile: Water =1:1), vortex mixing,
CO:COLLECTION_SUMMARY            	extraction at 4 ° C for 30 min, centrifugation at 12000 rpm and 4 ° C for 10
CO:COLLECTION_SUMMARY            	min, taking 300μL supernatant slowly through the extraction column, adding 500
CO:COLLECTION_SUMMARY            	μL eluent (30% acetonitrile), slowly through the extraction column, mixing the
CO:COLLECTION_SUMMARY            	two times of flow solution, LC-MS analysis.
CO:SAMPLE_TYPE                   	Plant roots
#TREATMENT
TR:TREATMENT_SUMMARY             	Take a dilution sample of 100μL and add 400 μL precipitator (acetonitrile:
TR:TREATMENT_SUMMARY             	Water =1:1), vortex mixing, extraction at 4 ° C for 30 min, centrifugation at
TR:TREATMENT_SUMMARY             	12000 rpm and 4 ° C for 10 min, taking 300μL supernatant slowly through the
TR:TREATMENT_SUMMARY             	extraction column, adding 500 μL eluent (30% acetonitrile), slowly through the
TR:TREATMENT_SUMMARY             	extraction column, mixing the two times of flow solution, LC-MS analysis.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	The concentration series of the standard solution were detected by LC-MS, and
SP:SAMPLEPREP_SUMMARY            	the ratio of the concentration of the standard product to the internal standard
SP:SAMPLEPREP_SUMMARY            	was taken as the horizontal coordinate and the ratio of the peak area of the
SP:SAMPLEPREP_SUMMARY            	standard product to the internal standard was taken as the vertical coordinate
SP:SAMPLEPREP_SUMMARY            	to investigate the linearity of the standard solution. QC samples were tested by
SP:SAMPLEPREP_SUMMARY            	inserting a number of needles at intervals in each batch of samples. The RSD of
SP:SAMPLEPREP_SUMMARY            	all QC samples was calculated with the concentration of the standard substance
SP:SAMPLEPREP_SUMMARY            	to evaluate stability. According to the established sample pretreatment and
SP:SAMPLEPREP_SUMMARY            	instrumental analysis methods, all samples were quantitatively analyzed.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	AB Sciex QTRAP 6500+
CH:COLUMN_NAME                   	Agilent Zorbax Eclipse Plus C18 (100 x 2.1mm, 1.8 um)
CH:SOLVENT_A                     	5mM Ammonium Acetate Aqueous Solution (Adjusted to pH 4.5 with Acetic Acid)
CH:SOLVENT_B                     	Acetonitrile
CH:FLOW_GRADIENT                 	The initial proportion of mobile phase B is set at 15%, which then linearly
CH:FLOW_GRADIENT                 	increases at a rate of 0.8% per minute until it reaches 45%, where it is held
CH:FLOW_GRADIENT                 	for 5 minutes to adequately elute moderately polar metabolites. Afterward, it
CH:FLOW_GRADIENT                 	increases at a rate of 2% per minute up to 90%, and finally remains at this
CH:FLOW_GRADIENT                 	composition for an additional 5 minutes to clean the chromatographic column and
CH:FLOW_GRADIENT                 	collect less polar metabolites.
CH:FLOW_RATE                     	0.35ml/min
CH:COLUMN_TEMPERATURE            	35
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	AB Sciex QTRAP 6500+
MS:INSTRUMENT_TYPE               	QTRAP
MS:MS_TYPE                       	EI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	The concentration series of the standard solution were detected by LC-MS, and
MS:MS_COMMENTS                   	the ratio of the concentration of the standard product to the internal standard
MS:MS_COMMENTS                   	was taken as the horizontal coordinate and the ratio of the peak area of the
MS:MS_COMMENTS                   	standard product to the internal standard was taken as the vertical coordinate
MS:MS_COMMENTS                   	to investigate the linearity of the standard solution. QC samples were tested by
MS:MS_COMMENTS                   	inserting a number of needles at intervals in each batch of samples. The RSD of
MS:MS_COMMENTS                   	all QC samples was calculated with the concentration of the standard substance
MS:MS_COMMENTS                   	to evaluate stability. According to the established sample pretreatment and
MS:MS_COMMENTS                   	instrumental analysis methods, all samples were quantitatively analyzed.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	Peak area
MS_METABOLITE_DATA_START
Samples	CK-1	CK-2	CK-3	CK-4	CK-5	CK-6	GH3_2-1	GH3_2-2	GH3_2-3	GH3_2-4	GH3_2-5	GH3_2-6
Factors	Sample source:Plant root | Phenotype:control	Sample source:Plant root | Phenotype:control	Sample source:Plant root | Phenotype:control	Sample source:Plant root | Phenotype:control	Sample source:Plant root | Phenotype:control	Sample source:Plant root | Phenotype:control	Sample source:Plant root | Phenotype:transgene	Sample source:Plant root | Phenotype:transgene	Sample source:Plant root | Phenotype:transgene	Sample source:Plant root | Phenotype:transgene	Sample source:Plant root | Phenotype:transgene	Sample source:Plant root | Phenotype:transgene
Adenosine	95440000	44840000	10230000	44610000	3631000	10900000	1.33E+08	1.56E+08	1.56E+08	1.09E+08	1.36E+08	71270000
Cytidine	12980000	16550000	10360000	11630000	19200000	17860000	18030000	21100000	36660000	29620000	21290000	21220000
Indole-3-acetic acid	76270	160900	64930	53850	66490	66070	44770	32120	19010	41260	35450	18780
Ademetionine	34570	53460	24950	21050	22900	41720	62760	60600	63240	37020	34590	61680
SDMA	264900	511000	297400	189600	231100	241500	819600	640300	524400	533200	418300	349700
5-Methylcytidine	174800	269200	195000	160900	200300	231900	286400	263900	365500	318500	188800	222800
Calycosin-7-O-beta-D-glucoside	375300	377100	611600	569400	446600	1621000	191500	276000	216000	464500	299000	133100
L-Leucine	32050000	40200000	19830000	18450000	24400000	16380000	45400000	45860000	40480000	38090000	38480000	20380000
Glycine	70050	54070	39400	57630	31790	36440	147300	129300	68820	154400	118000	77620
DL-Citrulline	1907000	2725000	1184000	1200000	1630000	1014000	3161000	3811000	2968000	3650000	2843000	2484000
beta-Nicotinamide Mononucleotide	14470	10140	13730	3970	13580	7282	149500	82070	37060	29020	327100	7945
H-Gly-Pro-OH	79420	153000	86270	89150	105000	96850	133300	168500	162500	157800	99720	140100
2-Amino-4-(methylthio)butyric acid	160900	236300	185200	154400	136400	123200	429500	375900	173300	199400	232700	215800
L-serine	1028000	1378000	817300	1003000	842400	815100	2526000	2055000	1482000	1811000	1971000	1274000
D-Phenylalanine	41970000	56930000	27990000	31710000	29630000	27540000	72090000	81700000	71820000	81320000	71130000	34260000
Nicotinamide	2743000	1949000	2886000	3217000	3306000	2752000	3629000	5181000	5094000	4267000	3317000	3659000
4-Acetamidobutyric Acid	277600	295700	155000	432800	460500	215900	438300	641900	545900	399900	644700	593400
Toringin	1.28E+08	91650000	1.06E+08	48330000	88490000	1.11E+08	1.22E+08	1.33E+08	1.48E+08	1.52E+08	1.2E+08	1.09E+08
Sattabacin	42380	40250	49080	82870	56250	77640	28600	28590	27640	43640	19840	32040
1,2-Benzenedicarboxylic acid	317600	343000	175700	183400	179500	199100	427000	510100	437900	491200	473800	236100
Phe-Pro	97220	96370	26750	30490	92440	50520	153800	242800	207100	270800	115200	120400
Oleamide	53710000	33510000	49150000	37360000	61430000	56830000	1.3E+08	69030000	93050000	43610000	53720000	1.02E+08
NG,NG-Dimethyl-L-arginine	300800	426400	397800	295000	335300	189300	668600	503700	584800	422900	444000	340000
N-Acetyl-L-leucine	23500000	17960000	18650000	22140000	19670000	19720000	26880000	33080000	27600000	25700000	25900000	24370000
2-Hydroxy-6-Aminopurine	1152000	953900	555600	226600	728200	362500	1510000	2085000	597000	1831000	1656000	1074000
N-(2-Hydroxyethyl)iminodiacetic acid	1885000	1218000	2250000	3101000	2511000	2654000	1320000	1439000	1113000	1128000	1062000	1504000
Hypoxanthine-9-beta-D-Arabinofuranoside	7042000	3330000	756800	3232000	290200	768300	9574000	11230000	11000000	7275000	9966000	5011000
Diethanolamine	202200	289300	160300	230100	180300	168500	519700	443600	313100	375600	360900	291000
Benzamidine	683100	893500	417400	490900	511900	407300	1180000	1265000	1200000	1323000	1217000	554600
Acetaminophen	785600	764600	397000	322800	400700	511500	1192000	1350000	959300	1173000	1038000	757300
Tetraethylammonium fluoride	5446000	6756000	4607000	3076000	6323000	6163000	4725000	11700000	9343000	9382000	8665000	5868000
5'-Deoxy-5'-(Methylthio)Adenosine	371200	667000	479600	498100	658500	480500	3269000	2536000	1213000	1460000	1347000	2232000
gamma-Glutamylglutamic acid	258300	220000	192100	111000	330300	257700	385300	347000	401100	267700	228500	380700
1-Methylhistidine	449500	302100	123100	121700	244700	198200	999400	1229000	942700	824300	686800	716600
S-ribosyl-L-homocysteine	107900	123400	59760	73420	99830	69310	130400	158300	163700	155200	123000	117100
Spermidine	11750	19080	13270	16780	11890	23090	88780	42860	21090	52930	18680	45880
S-Methyl-5'-thioadenosine	571900	1057000	779700	780200	1019000	713900	5295000	3938000	1974000	2262000	2102000	3573000
Purine	53200	72550	40390	41620	39220	31710	89310	90470	95150	105400	95390	42800
L-Saccharopine	601200	877200	502100	515900	646400	678000	918300	824800	987700	832600	642600	778900
Homoserine	7274000	7779000	3485000	4361000	3250000	2122000	10180000	9720000	8364000	8132000	9844000	4239000
DL-Leucine	711400	915400	432800	388900	566400	364300	1010000	1026000	948500	856100	908000	453600
Asp-glu	152000	183800	143800	146400	191200	151000	213000	254700	245900	345200	171600	230200
Allopurinol	35790	48990	15390	41320	29210	23560	90960	132000	95450	263500	60200	80200
5-Methyl-dl-tryptophan	93590	93010	103900	54410	107000	116200	151000	148900	133100	113200	89550	125500
1-Methylnicotinamide	21710	18620	12700	9047	4417	12930	67410	80410	73370	157700	39450	37030
D-Pyroglutamic acid	1697000	2032000	928200	4738100	1401000	1113000	10730000	11400000	8900000	17630000	6533000	8307000
methyl oxo pentanoate	80050	129800	112400	97320	148900	137100	80260	58300	81600	98370	108700	83070
Trimethylamine N-oxide	19710	43350	21510	17140	25910	30080	56590	42000	38540	51700	21760	35390
D-Myo-inositol 4-monophosohate	5644000	4072000	4238000	5203000	2490000	4772000	5254000	5087000	6885000	6808000	6363000	5070000
3'-Aenylic Acid	91310	87940	72280	43450	63410	82440	95980	93880	94650	95270	97190	84850
dAMP	97590	65810	67830	125200	158300	135900	70170	24630	67240	55820	12230	14330
1-Methylguanosine	36830	36410	16560	13530	28920	23900	44240	41360	43270	61360	44120	51590
dCMP	39440	39150	32380	31210	25800	48260	87980	110200	74410	78390	104300	64920
thiamine phosphate	15040	11420	2591	9211	12064	5702	20290	30110	32130	21280	36200	8914
dGMP	5831	6858	4472	9969	6349	10670	18780	8444	11713	11370	18820	15640
Scopine	22750	22690	28640	31340	22590	32720	17600	21020	13550	22780	20130	24770
Quinidine	13180	9801	14770	15470	21170	13680	15090	23150	25470	24180	22060	14190
Cephalotaxine	11133	12070	14080	8054	11980	34480	6339	9879	3228	13296	2591	8787
Deoxyarbutin	58200	112900	132000	110000	89420	63170	278300	109000	156700	121500	94060	170400
2,2'-Cyclouridine	59832	62870	44260	45611	34440	34610	89500	67250	106700	70711	102700	38520
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine	2655	3562	2463	3384	2350	5540	1907	2071	2322	2557	2273	949
Aloesin	7534	6921	4666	7006	6967	4120	10630	13710	8857	7287	6608	7034
Homoplantaginin	182200	127700	191400	239000	312300	548100	187400	147800	121900	112600	94220	161000
Tabersonine	242600	333800	203200	474700	601400	974100	116200	128700	84030	198700	64710	195900
Aloperine	7873	7236	9446	9516	9533	7409	17380	18410	17190	19770	9613	10630
VitaMin U	10750000	8440000	3973000	4002000	3009000	3070000	11080000	12220000	9608000	11080000	16830000	5999000
3-Amino-4-methylpentanoic acid	545300	292400	525800	494200	565000	305500	1229000	907700	696300	566600	546400	523500
D-Serine	6389000	7021000	4712000	5450000	5369000	4544000	12890000	12570000	8317000	10040000	11280000	7542000
1-Aminocyclopropanecarboxylic acid	3814000	3794000	1846000	1817000	1733000	1370000	4824000	4736000	4422000	4199000	5471000	2294000
L-Phenylalanine	40580000	56840000	26750000	29190000	28700000	26010000	69540000	79180000	70360000	78000000	66770000	31740000
Levodopa	68070	79130	79710	116600	123800	95720	271100	164500	117500	103900	108000	156000
Nobiletin	34120	34450	25350	42470	29420	50300	121200	116500	110900	147600	79820	64790
3-Hydroxy-9,10-Dimethoxypterocarpan	26070	71720	28320	43180	88870	95260	12370	27930	36090	33450	8735	40170
4-Hydroxycoumarin	25760	31140	4099	6044	14010	8567	53710	54470	41950	31080	33840	23520
Paeonol	127400	195400	139900	47430	163000	76090	223100	246000	248600	243300	237300	122900
Indirubin	9606	26930	3357	4406	5280	13540	142300	65500	41490	49670	18740	26420
Homoharringtonine	22470	44770	22090	26440	36950	32740	38340	25640	12910	16850	13940	8748
Pratensein-7-O-glucoside	89760	132100	236100	137700	294300	351100	38230	146600	111800	62570	112300	39840
Prim-O-glucosylcimifugin	113500	94080	344700	255900	290400	440200	54610	86280	52090	37650	107300	32240
Oxymatrine	64120	73000	34790	26490	41150	29010	213700	208600	106200	85970	137500	68260
Oxysophocarpine	9034	13720	4927	3295	7558	16200	84720	47370	18300	32830	28810	24450
ladanein	10970	86840	12090	39590	82270	47160	2981	14863	5341	5406	2008	11299
Sarsasapogenin	96170000	58780000	73020000	34280000	61390000	76010000	91840000	1.08E+08	1.09E+08	1.22E+08	99680000	71410000
N-Acetylthreonine	39740	60290	43170	42480	49480	40160	190500	100500	75920	66550	66420	69120
7-methylguanine	8256000	11170000	5352000	6074000	5826000	5110000	14270000	16340000	15230000	16050000	14340000	6826000
Chrysin O-hexoside	2.12E+08	1.48E+08	1.66E+08	78500000	1.51E+08	1.86E+08	2.07E+08	2.36E+08	2.37E+08	2.62E+08	2.2E+08	1.73E+08
Agmatine	105900	92660	82520	32400	59190	51950	204400	211900	178900	211000	105300	165500
Gallocatechin-gallocatechin	8287	22880	28320	8753	24620	36800	6104	7401	15100	11910	5730	9956
LysoPC 10:0	158100	202700	56820	75230	50890	66740	257900	195100	207900	132400	154100	107100
MAG (18:1)	5289	5666	3096	2133	2676	7611	10060	5598	9090	5429	8043	6590
Daidzin	1.61E+08	1.31E+08	1.4E+08	71970000	1.22E+08	1.58E+08	1.62E+08	1.81E+08	1.83E+08	2.02E+08	1.67E+08	1.44E+08
Guanosine monophosphate	74580	116200	119100	49470	44330	78090	368700	211800	222800	175200	456000	92590
Methionine sulfoxide	1179000	682400	841000	563300	366400	324400	2077000	1715000	1515000	1165000	2105000	1014000
Methylguanidine	322700	326300	143000	142500	159600	76490	438400	409700	408200	316400	476700	205800
Sissotrin	810800	819200	1484000	1131000	1575000	3494000	142700	330700	163300	358000	291100	186800
Peonidin O-hexoside	93500	204000	256800	326600	358700	432000	44530	121500	107700	49130	76300	30340
Delphinidin 3-O-Rutinoside	6016	9929	7571	12480	9894	14718	8438	7453	4511	5332	6902	3798
(-)-Norepinephrine N-hexoside	827200	929100	1426000	1484000	1359000	1880000	665600	778000	672300	625900	653300	1027000
1-Methyladenine	82090	145000	79080	76980	77270	56430	249000	156300	156200	160100	153600	114800
2-Methyladenosine	1712000	3067000	1851000	1555000	2413000	2562000	3324000	2742000	2777000	3632000	1978000	3601000
5-Sulfanyl-1-pentanesulfonamide	66530	44310	55920	40870	69540	49630	161300	75880	106500	44270	60940	120300
Apo-13-zeaxanthinone	392400	303000	535500	564100	665500	523300	335600	449600	367600	385600	281100	307900
Chinese bittersweet alkaloid II	30970	22630	26570	28310	44560	17780	37270	43390	44980	45610	38830	34830
Chrysoeriol 5-O-hexoside	171200	127700	240700	213800	349400	668200	154300	107200	107200	89970	91060	124300
GDP-L-fucose	14390	11380	10510	26050	8458	15100	11880	5480	1570	3657	12420	9189
IAA-Asp	455000	763100	789800	747100	1168000	1001000	410000	417200	389800	436700	350600	594500
Kaempferol 3-O-glucoside-2‘-O-rhamnoside	15630	10880	17010	32970	28720	35970	7799	9968	7007	5392	3615	3347
L-Homocystine	5779000	2784000	607400	2649000	248900	649800	8178000	9618000	9147000	6286000	8202000	4218000
Luteolin O-malonylhexoside	1561000	982700	1744000	1734000	1707000	3994000	887000	1340000	1150000	1724000	605700	351000
methylChrysoeriol 5-O-hexoside	54600	34480	37600	31790	58360	47450	61280	69170	57670	61040	48460	65190
methylQuercetin O-hexoside	639300	477700	329100	536900	636900	433300	732700	594400	741200	533900	697800	1275000
N-(9H-Purin-6-ylcarbamoyl)threonine	137000	95220	125700	90880	137700	144700	353000	199400	295600	132900	170100	257200
N,N-Caffeoyl, p-cinnamoylputrescine	8032	7545	3758	8434	11860	8799	24830	33090	15730	8475	14580	20560
N-p-Coumaroylspermidine	12970	15050	14410	18300	20600	14610	9437	11120	13690	10630	7748	16200
Pyridoxine	24470	38330	20780	41020	39450	43000	39240	48110	56940	44870	38690	57200
Xanthurenic acid O-hexoside	22308	2707	25481	29144	1499	28999	87050	51780	58690	109800	55320	68770
Linoleic acid	64040	38170	57070	38370	47160	50600	166800	89550	126100	41250	84650	112300
Selgin O-hexosyl-O-hexoside	190000	121300	97230	46970	41900	46440	113900	192400	226800	146600	154500	89730
N-Sinapoyl agmatine	11430	6428	12340	2087	9157	10780	22740	22780	19480	14620	15390	12950
Chrysoeriol O-malonylhexoside	275500	192500	405400	521900	648700	1206000	193500	163300	179900	204500	106600	137800
Orotic acid	307600	242200	248800	440800	463197	314200	1415000	855200	461000	411300	470200	1122000
L-Dihydroorotic acid	16680000	15530000	14920000	11640000	11670000	15350000	16810000	26550000	20190000	17960000	17350000	14150000
D-Threonine	1614000	1275000	694200	707000	676000	391900	1792000	1975000	1812000	1484000	2325000	820300
Gossypol	10791	11750	11491	11572	11797	14181	12070	19460	15864	17870	14400	14780
Auramine	123500	119100	91090	149400	106700	109500	101500	84740	73660	111700	85430	84050
Benzyl cinnamate	15300	19980	24950	12210	15880	18910	34140	47840	63910	62980	44190	21510
Vanillin	43230	24500	49520	75990	49890	29790	30225	23000	14960	25450	20240	28460
Nerol	6603	16410	6069	8678	13400	10970	15557	15690	27880	21740	15260	8917
N-p-Coumaroylputrescine	7170	11540	4535	7367	8137	17200	34170	32660	21490	28180	20830	17980
D-Threose	40000	56060	240610	23610	31140	47020	483000	630600	421800	965600	373000	521200
Phytocassane C	104200	116200	97050	153300	216200	197400	101400	113200	101400	106500	86870	84690
1,5-Diaminopentane	101000	67350	39050	6985	41910	39990	143500	101300	131100	203300	75480	85300
Icariside B2	14060	19360	50390	25230	37210	36450	14120	16400	18610	13940	13500	18190
HBOA	29860000	43470000	20210000	22100000	21690000	19380000	52320000	59850000	52550000	57720000	51640000	23420000
Isomangiferin	125900	122200	126900	205200	26870	180800	1015000	592400	304900	231000	360100	747300
L-Alanyl-L-Phenylalanine	73780	111800	44330	49160	37050	40070	75900	95980	122600	102900	87340	65710
L-Leucyl-L-phenylalanine	44020	65060	42910	42780	42420	51960	61460	75740	79170	98940	63360	62600
Elemol	16260000	18560000	17410000	18740000	15620000	21620000	14480000	10590000	16390000	15810000	14990000	14610000
Phenylethanolamine	36030	4948	3436	5598	8573	28850	21290	50130	32150	63770	33560	27730
D-Panthenol	9249	5553	7784	16770	9812	12390	1388000	1467000	881000	2091000	685600	848100
Luteolin	69670	77740	69950	126500	145200	154800	28550	42960	76590	43860	37780	47740
Diosmetin	1303000	2183000	3104000	4108000	5233000	6153000	372900	245100	188800	475000	202800	594900
Quinic acid	1470000	849200	2092000	2584000	198900	1398000	8265000	2521000	3615000	2066000	2129000	7034000
DL-Panthenol	5715	3157	21626	6756	4168	28479	240200	213500	177700	448300	128300	158200
p-Coumaric Acid	41710	70590	25650	23010	45050	61850	11100	24900	15520	38540	7680	23180
3,4-Dihydroxyphenylacetic acid	46110	37480	52120	60490	75290	48120	28490	38360	37340	44540	19850	42150
Tartaric acid	326000	387600	482800	506500	623500	346200	163700	211300	312700	222200	148500	190400
Scutellarein	42610	58140	57800	55130	66770	82290	27040	32700	53320	33090	25160	28720
Tectorigenin	2720	7229	8806	14630	19660	22510	1261	4537	2814	3476	4177	3195
Engeletin	33710	40600	46480	31460	71320	59810	37510	20220	36200	29740	30100	31050
Isoguanosine	908300	878400	574900	432800	542900	629900	1346000	1029000	1293000	1205000	971800	755000
Sesamoside	8126	26140	25470	27000	29850	30310	6875	2458	4418	6502	8038	4107
Uridine 5'-monophosphate	115800	55460	66110	70050	23540	27880	212000	147200	236700	137300	222100	63460
L-Threonine	171800	151200	93690	151900	85080	38770	154200	361700	277200	170400	387200	147800
Cytosine	8818	6211	9118	9014	8454	6799	17820	16060	10970	15690	16760	12240
cis-Aconitic acid	196800	119000	227900	486500	88810	232400	3363000	1205000	1037000	212300	451200	1569000
Citric acid	1601000	1935000	3855000	3362000	467000	3212000	25880000	6002000	11190000	2035000	4052000	16310000
L-Pyroglutamic acid	10520	5925	5886	9160	4749	4817	21650	29010	33900	46010	21590	22600
L-Arabinitol	80980	75090	66190	82260	98040	52920	35530	15340	38100	44800	33210	24730
N-Acetylornithine	71950	85870	45030	83550	60200	95060	60360	44140	54060	53140	34890	59940
D-Galacturonic acid	153500	78340	201400	230300	30010	207000	812400	253000	399500	208700	262600	821900
GA7-1	4997000	3413000	4243000	7283000	6034000	5985000	3365000	949000	2774000	3476000	1500000	2227000
3-Hydroxyanthranilic Acid	38540	36180	40600	43740	93750	49990	22990	22700	25990	26340	13320	55340
Lactic acid	24310	80576	33480	18720	19080	16760	106400	98700	236900	405500	112800	160700
9(S)-HOTrE	109700	74970	73710	73360	68410	71970	62320	26310	67750	40280	34690	48980
alpha-Benzylsuccinic acid	128600	145000	129900	172600	121800	138500	139000	69080	116500	96160	89030	139400
ADP-ribose	13220	13678	14840	8075	9009	10730	119000	26610	25040	13050	36430	11550
Citraconic acid	100000	72940	127500	228300	30770	67590	926800	229000	363500	111300	144300	381000
deoxyribose-phosphate	27650	24830	18470	15020	31810	12240	42440	23870	31530	29650	32950	34510
D-Glucarate	1734000	2808000	2169000	1883000	2081000	1854000	2196000	2459000	2903000	5509000	4000000	2459000
D-Glucopyranose	274000	407000	233500	422600	403300	263500	131400	230200	252400	242800	203200	140800
L-Cysteinesulfinic acid	4969	10810	9323	10391	10270	10939	13900	16890	19250	21050	19740	7948
D-threo-Isocitric acid	3696000	1451000	3507000	4056000	286800	2819000	11880000	5751000	7256000	2747000	4862000	12390000
L-Homoserine	3265	2695	1648	6877	2981	6299	25740	8753	3242	7437	7016	6872
D-Arabinose 5-phosphate	238100	198300	240600	137300	115700	57080	317300	340700	295300	189300	409800	172600
UDP-galactose	1017000	151800	678600	522000	55190	108900	1521000	1435000	1992000	578300	1641000	949900
Methyl protocatechuate	97430	131400	73890	128000	144400	238400	21410	48730	47710	106400	30720	74980
Oxyresveratrol	197900	529000	220500	349800	228900	331700	251900	207400	202600	182000	163800	160600
Vidarabine	225600	77760	35130	117200	9139	20600	281500	231600	287900	177600	299200	118500
Propylparaben	5530	16700	8998	20650	13950	20370	46570	30200	19520	23990	21570	31350
Hexadecanedioic acid	14390	20790	18640	18380	16060	13000	14570	14020	15030	11750	10850	11530
Calycosin	10000000	13270000	16440000	20210000	28670000	33970000	1294000	1574000	1163000	2557000	1809000	2736000
beta-L-Arabinose	3779000	5497000	6042000	5479000	8553000	4996000	1899000	1732000	2435000	2572000	2117000	2247000
Hastatoside	13960	13150	22730	49370	25020	41750	11820	5804	4616	10830	7212	12560
Choline bitartrate	715200	848900	885600	737700	1118000	682400	408700	399400	376900	493500	346700	383500
Cytidylic acid	27100	50410	34570	23820	15410	24020	61760	45610	91260	55180	72570	34790
2-Amino-3-hydroxypropionic acid	218400	237400	218600	144000	93850	49080	396600	260900	340500	171600	368400	242000
D-Ribose	237200	384800	399000	420300	556800	259300	184000	198800	209500	233100	137500	139400
Peonidin chloride	16210	18090	19660	15590	15030	17930	11110	15130	12840	13340	13780	11610
Acetyl tryptophan	52560	69340	62810	106700	136900	105300	37870	26230	47800	42960	28090	55250
Myristoleic acid	66340	60090	69940	383000	98870	118600	27690	24680	45250	29570	30620	53250
13(S)-HOTrE	202400	175300	161800	171800	185100	202000	138000	113100	172500	116300	107100	138800
9-KODE	226300	181800	165100	160800	189100	197600	159900	112000	161600	128900	101200	128300
12,13-EODE	1533000	1192000	1138000	1281000	1191000	1390000	933300	408300	1033000	725900	479200	728900
UDP-D-glucose	898000	140700	419500	335700	47220	69880	1332000	738700	1290000	359400	1215000	465500
Gallic acid O-Hexoside	101000	45220	137800	44850	152800	120700	6883	17970	22290	77490	14440	15190
Di-O-methylquercetin	3976000	4209000	3465000	5737000	4259000	4568000	3750000	2116000	3451000	4082000	2007000	2880000
L(-)-Malic acid	34650000	25990000	43090000	37600000	28490000	33730000	70040000	34570000	47320000	41920000	46590000	66870000
N-[(-)-Jasmonoyl]-(L)-Isoleucine	5824	4585	4546	3109	5053	4893	11500	6901	10760	11670	6340	5031
5-oxoproline	21860	5258	7279	10790	12250	4513	31940	39380	48780	61880	32810	22760
2'-Hydroxydaidzein	1077000	1234000	703000	1243000	1894000	1916000	271800	275800	890000	818700	273700	649300
Trifolin	140300	120900	107300	132100	121000	144500	106800	59430	93740	71160	48630	80760
2'-Hydroxygenistein	1362000	1827000	1808000	2833000	3350000	3873000	559500	725700	1263000	940800	576000	799600
Prunetin	614900	496900	711700	1007000	998500	1797000	207000	269400	337900	507700	213500	267800
D-Xylose	53560	46580	95460	82310	104300	59690	40220	25390	46820	42510	37780	29510
Fmoc-Ile-OH	35010	30980	38170	35500	8051	28290	3619	3781	9102	7374	10679	8813
Rhein 8-Glucoside	17490	14900	16630	20710	16450	33280	16650	7818	8050	12940	11290	11330
4'-Hydroxyacetophenone	6784	2717	12780	6079	10330	7082	50870	26320	21910	53320	20740	26100
Pinoresinol Diglucoside	39120	40840	44470	81700	113000	73840	26370	28730	29710	30620	11770	46360
Crocetin	62110	45540	45920	71240	60950	49030	47740	20890	38000	51840	21860	38480
Coumestrol	57700000	52000000	43270000	63530000	60470000	71340000	26810000	36170000	52090000	49500000	34320000	47200000
D-2-Hydroxypentanedioic acid disodium salt	235100	105200	235900	298000	35040	283100	1235000	446300	588600	219500	252200	1042000
D-Xylulose	6033000	5531000	5949000	6886000	8330000	5585000	1942000	2111000	2586000	2149000	1877000	2051000
Isocitrate	4326000	1633000	4847000	6188000	664600	8462000	16600000	6960000	12430000	5013000	7432000	22320000
P-Coumaryl Alcohol	1480000	1272000	1806000	1719000	2344000	1333000	505800	665900	778800	713400	575600	640900
Physcion 8-O-Beta-D-Monoglucoside	159700	176000	285100	383500	160200	691100	67930	85930	102700	146800	54990	19780
Cyclic AMP	137700	184100	222300	91820	97620	111900	616300	246000	272100	163200	342900	137200
2–furanoic acid	385600	111700	475500	636700	49210	546500	1461000	855700	971900	274500	546100	1794000
Fumaric Acid	1295000	909600	1352000	1156000	812100	1353000	2156000	1324000	1426000	1267000	1349000	1979000
2-Oxoadipic acid	93580	145100	121400	141800	63810	116400	56970	55700	112800	79890	68000	81250
N alpha-Acetyl-L-glutamine	871300	1194000	625300	1536000	1341000	1634000	724100	656700	582000	847400	420700	530900
13(S)-HODE;13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid	1618000	1392000	1290000	1583000	1455000	1878000	1255000	971100	1491000	1048000	754400	1067000
(-)-Jasmonoyl-L-isoleucine	2115	3308	2445	8338	3051	7050	16120	11550	16350	14460	13100	6422
9S-Hydroxy-10E,12Z-octadecadienoic acid	2657000	2352000	2067000	2839000	2449000	2964000	2015000	1781000	2350000	1696000	1330000	1928000
D-Arabinono-1,4-lactone	26270	32390	30010	52030	19540	52360	195600	107000	63830	29000	41090	125400
9,10,13-Trihydroxyoctadec-11-enoic acid	5539000	6095000	5018000	7761000	6747000	6660000	5894000	4194000	5347000	5805000	3194000	4253000
UDP-D-xylose	167000	33430	56890	60320	11960	8818	379900	175600	152600	53670	323000	151600
Koaburaside	72760	67110	100900	91400	120300	158900	17810	20460	23780	38110	24070	30100
Ayapin	55600	59540	39340	99220	65340	80250	46500	25770	34390	37140	24070	25420
Eucommiol	215000	366200	207600	503000	426300	407400	246000	185600	176900	221800	127800	161100
1-O-Galloyl-D-glucose	36090	26130	28470	28620	64110	50040	10730	10620	14000	15090	11580	22940
2,2-Dimethylsuccinic acid	68550	88630	79980	95450	117800	129300	265400	279600	110200	133000	134800	126700
L-Citramalic acid	133700	58510	152300	185900	142884	113300	488500	233500	303700	115500	162600	627400
12(13)-EpOME	2791000	2216000	2121000	2620000	2378000	2952000	2181000	1665000	2414000	1780000	1323000	1774000
2,6-Dimethyl-7-octene-2,3,6-triol	224900	391000	240100	418200	426200	433500	291100	203800	189700	179900	145200	170000
N-Acetyl-L-Tryptophan	252100	311000	398700	481700	558500	416700	214000	175200	193800	183100	128100	199300
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	log2(GH3_2/CK)	P-value	VIP
Adenosine	1.86	0.005987	1.607178
Cytidine	0.73	0.006659	1.561119
Indole-3-acetic acid	-1.35	0.001927	1.709407
Ademetionine	0.68	0.024876	1.483948
SDMA	0.92	0.005509	1.663813
5-Methylcytidine	0.41	0.047245	1.275903
Calycosin-7-O-beta-D-glucoside	-1.34	0.013019	1.543096
L-Leucine	0.59	0.043985	1.305939
Glycine	1.26	0.000872	1.809119
DL-Citrulline	0.96	0.001348	1.797739
beta-Nicotinamide Mononucleotide	3.32	0.011338	1.508
H-Gly-Pro-OH	0.49	0.016484	1.514005
2-Amino-4-(methylthio)butyric acid	0.7	0.027574	1.463266
L-serine	0.91	0.000663	1.841753
D-Phenylalanine	0.93	0.00463	1.635105
Nicotinamide	0.57	0.004305	1.648428
4-Acetamidobutyric Acid	0.82	0.007544	1.587921
Toringin	0.44	0.041975	1.30986
Sattabacin	-0.95	0.002565	1.712199
1,2-Benzenedicarboxylic acid	0.88	0.004529	1.645149
Phe-Pro	1.49	0.002845	1.734647
Oleamide	0.74	0.035494	1.393092
NG,NG-Dimethyl-L-arginine	0.6	0.018908	1.44245
N-Acetyl-L-leucine	0.42	0.000622	1.863234
2-Hydroxy-6-Aminopurine	1.13	0.021146	1.483171
N-(2-Hydroxyethyl)iminodiacetic acid	-0.84	0.003663	1.644888
Hypoxanthine-9-beta-D-Arabinofuranoside	1.8	0.006483	1.598443
Diethanolamine	0.9	0.000554	1.8667
Benzamidine	0.98	0.003849	1.651269
Acetaminophen	1.02	0.0014	1.80464
Tetraethylammonium fluoride	0.61	0.046033	1.287216
5'-Deoxy-5'-(Methylthio)Adenosine	1.93	3.90E-05	2.03589
gamma-Glutamylglutamic acid	0.55	0.042912	1.37349
1-Methylhistidine	1.9	0.000102	1.984884
S-ribosyl-L-homocysteine	0.66	0.003877	1.688591
Spermidine	1.49	0.005606	1.678699
S-Methyl-5'-thioadenosine	1.95	4.00E-05	2.033297
Purine	0.89	0.006156	1.576876
L-Saccharopine	0.38	0.023547	1.4538
Homoserine	0.83	0.02515	1.392952
DL-Leucine	0.62	0.041931	1.311862
Asp-glu	0.59	0.004045	1.670771
Allopurinol	1.89	0.000895	1.805365
5-Methyl-dl-tryptophan	0.42	0.049791	1.353302
1-Methylnicotinamide	2.51	0.000271	1.882377
D-Pyroglutamic acid	2.41	6.68E-05	1.947296
methyl oxo pentanoate	-0.46	0.032335	1.421937
Trimethylamine N-oxide	0.64	0.043236	1.351781
D-Myo-inositol 4-monophosohate	0.42	0.038217	1.234331
3'-Aenylic Acid	0.34	0.040386	1.335496
dAMP	-1.41	0.008686	1.565442
1-Methylguanosine	0.87	0.004183	1.681205
dCMP	1.26	2.93E-05	2.004203
thiamine phosphate	1.41	0.012226	1.501082
dGMP	0.94	0.005739	1.575037
Scopine	-0.42	0.02436	1.387378
Quinidine	0.49	0.039596	1.237344
Cephalotaxine	-1.05	0.04265	1.207555
Deoxyarbutin	0.71	0.046792	1.274663
2,2'-Cyclouridine	0.75	0.023626	1.344035
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine	-0.72	0.028946	1.410453
Aloesin	0.54	0.040475	1.390048
Homoplantaginin	-0.95	0.031686	1.293401
Tabersonine	-1.84	0.002454	1.672814
Aloperine	0.86	0.00192	1.739856
VitaMin U	1	0.013111	1.495481
3-Amino-4-methylpentanoic acid	0.71	0.027305	1.422731
D-Serine	0.9	0.000275	1.911418
1-Aminocyclopropanecarboxylic acid	0.85	0.014881	1.479327
L-Phenylalanine	0.92	0.006601	1.59435
Levodopa	0.7	0.027153	1.448595
Nobiletin	1.56	4.97E-05	1.963491
3-Hydroxy-9,10-Dimethoxypterocarpan	-1.15	0.041794	1.251279
4-Hydroxycoumarin	1.41	0.007334	1.640953
Paeonol	0.81	0.024894	1.403154
Indirubin	2.44	0.002381	1.774053
Homoharringtonine	-0.67	0.047768	1.189422
Pratensein-7-O-glucoside	-1.27	0.017925	1.464923
Prim-O-glucosylcimifugin	-2.05	0.0015	1.772424
Oxymatrine	1.61	0.00154	1.808581
Oxysophocarpine	2.11	0.00124	1.836684
ladanein	-2.73	0.003529	1.605248
Sarsasapogenin	0.58	0.021078	1.429716
N-Acetylthreonine	1.04	0.004646	1.703853
7-methylguanine	0.99	0.003738	1.657959
Chrysin O-hexoside	0.5	0.030455	1.373283
Agmatine	1.34	0.000895	1.850705
Gallocatechin-gallocatechin	-1.2	0.031623	1.359023
LysoPC 10:0	0.78	0.035784	1.364096
MAG (18:1)	0.75	0.025316	1.408709
Daidzin	0.4	0.040113	1.319887
Guanosine monophosphate	1.66	0.003265	1.648691
Methionine sulfoxide	1.27	0.002408	1.707534
Methylguanidine	0.94	0.016675	1.467172
Sissotrin	-2.66	7.22E-05	1.957478
Peonidin O-hexoside	-1.96	0.001445	1.771904
Delphinidin 3-O-Rutinoside	-0.73	0.020389	1.411564
(-)-Norepinephrine N-hexoside	-0.83	0.003532	1.653942
1-Methyladenine	0.93	0.002062	1.737261
2-Methyladenosine	0.45	0.046855	1.327647
5-Sulfanyl-1-pentanesulfonamide	0.8	0.046548	1.343018
Apo-13-zeaxanthinone	-0.48	0.039807	1.290007
Chinese bittersweet alkaloid II	0.51	0.014437	1.46865
Chrysoeriol 5-O-hexoside	-1.39	0.0081	1.541997
GDP-L-fucose	-0.95	0.048965	1.23118
IAA-Asp	-0.92	0.002222	1.695518
Kaempferol 3-O-glucoside-2‘-O-rhamnoside	-1.92	0.000541	1.812336
L-Homocystine	1.84	0.005809	1.613797
Luteolin O-malonylhexoside	-0.95	0.044366	1.289721
methylChrysoeriol 5-O-hexoside	0.45	0.014624	1.563353
methylQuercetin O-hexoside	0.58	0.036136	1.358734
N-(9H-Purin-6-ylcarbamoyl)threonine	0.94	0.004607	1.687002
N,N-Caffeoyl, p-cinnamoylputrescine	1.27	0.006533	1.69369
N-p-Coumaroylspermidine	-0.47	0.021592	1.38862
Pyridoxine	0.46	0.038227	1.322526
Xanthurenic acid O-hexoside	1.96	0.008733	1.523868
Linoleic acid	1.07	0.009813	1.59032
Selgin O-hexosyl-O-hexoside	0.76	0.048811	1.261231
N-Sinapoyl agmatine	1.04	0.015977	1.518865
Chrysoeriol O-malonylhexoside	-1.72	0.004244	1.649327
Orotic acid	1.23	0.00971	1.628774
L-Dihydroorotic acid	0.39	0.032486	1.397952
D-Threonine	0.92	0.020145	1.42582
Gossypol	0.39	0.006507	1.610062
Auramine	-0.37	0.019041	1.445227
Benzyl cinnamate	1.35	0.000986	1.746174
Vanillin	-0.93	0.010913	1.520575
Nerol	0.75	0.040332	1.260473
N-p-Coumaroylputrescine	1.47	0.000514	1.876779
D-Threose	2.95	6.78E-05	1.951624
Phytocassane C	-0.57	0.034949	1.306652
1,5-Diaminopentane	1.32	0.019598	1.470605
Icariside B2	-0.94	0.016892	1.470579
HBOA	0.92	0.007339	1.579101
Isomangiferin	2.04	0.003365	1.714518
L-Alanyl-L-Phenylalanine	0.62	0.029433	1.352238
L-Leucyl-L-phenylalanine	0.6	0.002243	1.703854
Elemol	-0.31	0.018392	1.54228
Phenylethanolamine	1.38	0.013013	1.521609
D-Panthenol	6.9	1.59E-09	2.146201
Luteolin	-1.21	0.002162	1.744632
Diosmetin	-3.4	1.80E-05	2.00028
Quinic acid	1.57	0.025257	1.394867
DL-Panthenol	4.28	1.26E-05	2.006581
p-Coumaric Acid	-1.14	0.01856	1.379465
3,4-Dihydroxyphenylacetic acid	-0.6	0.022287	1.385458
Tartaric acid	-1.09	0.000421	1.872625
Scutellarein	-0.85	0.00153	1.768396
Tectorigenin	-1.95	0.008243	1.588214
Engeletin	-0.61	0.029766	1.384668
Isoguanosine	0.73	0.005111	1.641038
Sesamoside	-2.18	0.000258	1.939094
Uridine 5'-monophosphate	1.5	0.006128	1.562534
L-Threonine	1.11	0.019715	1.416241
Cytosine	0.88	0.000148	1.911746
cis-Aconitic acid	2.53	0.007168	1.63474
Citric acid	2.18	0.020354	1.45566
L-Pyroglutamic acid	2.08	1.32E-05	1.99642
L-Arabinitol	-1.24	0.000516	1.907865
N-Acetylornithine	-0.52	0.0323	1.3001
D-Galacturonic acid	1.61	0.01717	1.461438
GA7-1	-1.16	0.004201	1.70255
3-Hydroxyanthranilic Acid	-0.86	0.023052	1.354905
Lactic acid	2.53	0.000292	1.845308
9(S)-HOTrE	-0.75	0.006345	1.617686
alpha-Benzylsuccinic acid	-0.36	0.048318	1.284173
ADP-ribose	1.73	0.032299	1.367737
Citraconic acid	1.78	0.019033	1.459317
deoxyribose-phosphate	0.58	0.025729	1.400632
D-Glucarate	0.64	0.031668	1.247078
D-Glucopyranose	-0.73	0.008697	1.596225
L-Cysteinesulfinic acid	0.8	0.019203	1.361483
D-threo-Isocitric acid	1.5	0.03065	1.366086
L-Homoserine	1.31	0.041073	1.340797
D-Arabinose 5-phosphate	0.8	0.041194	1.286405
UDP-galactose	1.67	0.011615	1.498398
Methyl protocatechuate	-1.3	0.006836	1.59057
Oxyresveratrol	-0.66	0.031876	1.318277
Vidarabine	1.52	0.01347	1.478872
Propylparaben	1	0.012641	1.536974
Hexadecanedioic acid	-0.38	0.017836	1.429517
Calycosin	-3.46	1.63E-06	2.07396
beta-L-Arabinose	-1.4	1.77E-05	2.037276
Hastatoside	-1.65	0.00296	1.701228
Choline bitartrate	-1.05	1.06E-05	2.017652
Cytidylic acid	1.04	0.006036	1.550573
2-Amino-3-hydroxypropionic acid	0.88	0.031431	1.340975
D-Ribose	-1.03	0.001344	1.775966
Peonidin chloride	-0.39	0.001279	1.7693
Acetyl tryptophan	-1.16	0.002299	1.732196
Myristoleic acid	-1.91	0.004472	1.683361
13(S)-HOTrE	-0.48	0.001699	1.730027
9-KODE	-0.5	0.003144	1.653634
12,13-EODE	-0.84	0.002335	1.733963
UDP-D-glucose	1.49	0.021954	1.39238
Gallic acid O-Hexoside	-1.96	0.002818	1.725967
Di-O-methylquercetin	-0.51	0.020629	1.458469
L(-)-Malic acid	0.59	0.014868	1.460616
N-[(-)-Jasmonoyl]-(L)-Isoleucine	0.89	0.006171	1.590955
5-oxoproline	1.93	0.000426	1.831819
2'-Hydroxydaidzein	-1.34	0.005033	1.658572
Trifolin	-0.73	0.001737	1.713973
2'-Hydroxygenistein	-1.62	0.000366	1.883977
Prunetin	-1.64	0.000775	1.834964
D-Xylose	-0.99	0.002412	1.784008
Fmoc-Ile-OH	-2.02	0.001196	1.835092
Rhein 8-Glucoside	-0.81	0.007598	1.588053
4'-Hydroxyacetophenone	2.12	0.000297	1.868548
Pinoresinol Diglucoside	-1.17	0.010169	1.495242
Crocetin	-0.61	0.023388	1.431515
Coumestrol	-0.5	0.017395	1.488678
D-2-Hydroxypentanedioic acid disodium salt	1.66	0.026572	1.412406
D-Xylulose	-1.59	6.98E-08	2.122817
Isocitrate	1.43	0.029751	1.358723
P-Coumaryl Alcohol	-1.35	8.38E-06	2.044681
Physcion 8-O-Beta-D-Monoglucoside	-1.95	0.004282	1.687988
Cyclic AMP	1.07	0.029115	1.366605
2–furanoic acid	1.42	0.048181	1.279944
Fumaric Acid	0.46	0.03278	1.369169
2-Oxoadipic acid	-0.58	0.036753	1.392755
N alpha-Acetyl-L-glutamine	-0.93	0.006351	1.577096
13(S)-HODE;13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid	-0.48	0.009066	1.533912
(-)-Jasmonoyl-L-isoleucine	1.56	0.001437	1.712483
9S-Hydroxy-10E,12Z-octadecadienoic acid	-0.46	0.005948	1.57382
D-Arabinono-1,4-lactone	1.4	0.032155	1.431401
9,10,13-Trihydroxyoctadec-11-enoic acid	-0.39	0.032006	1.343566
UDP-D-xylose	1.86	0.013753	1.49741
Koaburaside	-1.98	1.25E-05	2.040177
Ayapin	-1.04	0.001722	1.75106
Eucommiol	-0.92	0.00682	1.574044
1-O-Galloyl-D-glucose	-1.45	0.000381	1.85029
2,2-Dimethylsuccinic acid	0.85	0.017572	1.542773
L-Citramalic acid	1.29	0.029005	1.407701
12(13)-EpOME	-0.43	0.011356	1.498855
2,6-Dimethyl-7-octene-2,3,6-triol	-0.85	0.004079	1.613497
N-Acetyl-L-Tryptophan	-1.14	0.000246	1.878943
METABOLITES_END
#END