#METABOLOMICS WORKBENCH grangel0955_20240930_102036 DATATRACK_ID:5251 STUDY_ID:ST003562 ANALYSIS_ID:AN005853 PROJECT_ID:PR002196 VERSION 1 CREATED_ON 11-21-2024 #PROJECT PR:PROJECT_TITLE Multiple, redundant carboxylic acid transporters support mitochondrial PR:PROJECT_TITLE metabolism in Plasmodium falciparum PR:PROJECT_SUMMARY The mitochondrion of the deadliest human malaria parasite, Plasmodium PR:PROJECT_SUMMARY falciparum, is an essential source of cellular acetyl-CoA during the asexual PR:PROJECT_SUMMARY blood-stage of the parasite life cycle. Indeed, blocking mitochondrial PR:PROJECT_SUMMARY acetyl-CoA synthesis leads to a hypoacetylated proteome and parasite death. We PR:PROJECT_SUMMARY previously determined that mitochondrial acetyl-CoA is primarily synthesized PR:PROJECT_SUMMARY from glucose-derived pyruvate by α-ketoacid dehydrogenases. Here, we asked if PR:PROJECT_SUMMARY inhibiting the import of glycolytic pyruvate across the mitochondrial inner PR:PROJECT_SUMMARY membrane would affect acetyl-CoA production and, thus, could be a potential PR:PROJECT_SUMMARY target for novel antimalarial drug development. We selected the two predicted PR:PROJECT_SUMMARY mitochondrial pyruvate carrier proteins (MPC1 and MPC2) for genetic knockout and PR:PROJECT_SUMMARY isotopic metabolite tracing via HPLC-MS metabolomic analysis. Surprisingly, we PR:PROJECT_SUMMARY observed that asexual blood-stage parasites could survive the loss of either or PR:PROJECT_SUMMARY both proteins with only minor asexual blood-stage growth defects, despite a PR:PROJECT_SUMMARY substantial reduction in the amount of glucose-derived isotopic labelling into PR:PROJECT_SUMMARY acetyl-CoA. Furthermore, genetic deletion of two additional mitochondrial PR:PROJECT_SUMMARY carboxylic acid transporters â DTC (di/tricarboxylic acid carrier) and YHM2 (a PR:PROJECT_SUMMARY putative citrate/α-ketoglutarate carrier protein) â only mildly affected PR:PROJECT_SUMMARY asexual blood-stage replication, even in the context of MPC-deficiency. Although PR:PROJECT_SUMMARY we observed no added impact on the incorporation of glucose carbon into PR:PROJECT_SUMMARY acetyl-CoA in these quadruple knockout mutants, we noted a large decrease in PR:PROJECT_SUMMARY glutamine-derived label in tricarboxylic acid cycle metabolites, suggesting that PR:PROJECT_SUMMARY DTC and YHM2 both import glutamine derivatives into the mitochondrion. PR:PROJECT_SUMMARY Altogether, our results expose redundant routes used to fuel the mitochondria of PR:PROJECT_SUMMARY blood-stage malaria parasites with imported carbon from two major carbon sources PR:PROJECT_SUMMARY â glucose and glutamine. PR:INSTITUTE Pennsylvania State University PR:DEPARTMENT Biochemistry and Molecular Biology PR:LABORATORY Manuel Llinás PR:LAST_NAME Manuel PR:FIRST_NAME Llinás PR:ADDRESS 491 Pollock Road, Millennium Science Complex, W126 PR:EMAIL manuel@psu.edu PR:PHONE 814-867-3444 PR:DOI http://dx.doi.org/10.21228/M8RV6M #STUDY ST:STUDY_TITLE Multiple, redundant carboxylic acid transporters support mitochondrial ST:STUDY_TITLE metabolism in Plasmodium falciparum ST:STUDY_SUMMARY The mitochondrion of the deadliest human malaria parasite, Plasmodium ST:STUDY_SUMMARY falciparum, is an essential source of cellular acetyl-CoA during the asexual ST:STUDY_SUMMARY blood-stage of the parasite life cycle. Indeed, blocking mitochondrial ST:STUDY_SUMMARY acetyl-CoA synthesis leads to a hypoacetylated proteome and parasite death. We ST:STUDY_SUMMARY previously determined that mitochondrial acetyl-CoA is primarily synthesized ST:STUDY_SUMMARY from glucose-derived pyruvate by α-ketoacid dehydrogenases. Here, we asked if ST:STUDY_SUMMARY inhibiting the import of glycolytic pyruvate across the mitochondrial inner ST:STUDY_SUMMARY membrane would affect acetyl-CoA production and, thus, could be a potential ST:STUDY_SUMMARY target for novel antimalarial drug development. We selected the two predicted ST:STUDY_SUMMARY mitochondrial pyruvate carrier proteins (MPC1 and MPC2) for genetic knockout and ST:STUDY_SUMMARY isotopic metabolite tracing via HPLC-MS metabolomic analysis. Surprisingly, we ST:STUDY_SUMMARY observed that asexual blood-stage parasites could survive the loss of either or ST:STUDY_SUMMARY both proteins with only minor asexual blood-stage growth defects, despite a ST:STUDY_SUMMARY substantial reduction in the amount of glucose-derived isotopic labelling into ST:STUDY_SUMMARY acetyl-CoA. Furthermore, genetic deletion of two additional mitochondrial ST:STUDY_SUMMARY carboxylic acid transporters â DTC (di/tricarboxylic acid carrier) and YHM2 (a ST:STUDY_SUMMARY putative citrate/α-ketoglutarate carrier protein) â only mildly affected ST:STUDY_SUMMARY asexual blood-stage replication, even in the context of MPC-deficiency. Although ST:STUDY_SUMMARY we observed no added impact on the incorporation of glucose carbon into ST:STUDY_SUMMARY acetyl-CoA in these quadruple knockout mutants, we noted a large decrease in ST:STUDY_SUMMARY glutamine-derived label in tricarboxylic acid cycle metabolites, suggesting that ST:STUDY_SUMMARY DTC and YHM2 both import glutamine derivatives into the mitochondrion. ST:STUDY_SUMMARY Altogether, our results expose redundant routes used to fuel the mitochondria of ST:STUDY_SUMMARY blood-stage malaria parasites with imported carbon from two major carbon sources ST:STUDY_SUMMARY â glucose and glutamine. ST:INSTITUTE Pennsylvania State University ST:DEPARTMENT Biochemistry and Molecular Biology ST:LABORATORY Manuel Llinás ST:LAST_NAME Manuel ST:FIRST_NAME Llinà s ST:ADDRESS 491 Pollock Road ST:EMAIL manuel@psu.edu ST:PHONE 8148673444 ST:SUBMIT_DATE 2024-09-30 #SUBJECT SU:SUBJECT_TYPE Cultured cells SU:SUBJECT_SPECIES Plasmodium falciparum SU:TAXONOMY_ID 5833 SU:GENOTYPE_STRAIN NF54 attB SU:CELL_BIOSOURCE_OR_SUPPLIER Prigge Lab, Johns Hopkins University #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - 20240206_2KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_2KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_2KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_2KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_2KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_2KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-2KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-2KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-2KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-2KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-2KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-2KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-2KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-2KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-2KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-2KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-2KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-2KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_2KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_2KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_2KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_2KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_2KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_2KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-2KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-2KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-2KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-2KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-2KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-2KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-2KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-2KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-2KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-2KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-2KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-2KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_3KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_3KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20211215_3KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_3KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20211215_3KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_3KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20220330_3KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_3KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20220330_3KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_3KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20220330_3KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_3KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20220429_3KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_3KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20220429_3KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_3KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20220429_3KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_3KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_3KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_3KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_3KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_3KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_3KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_3KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_3KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_3KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20211215_3KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_3KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20211215_3KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_3KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20220330_3KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_3KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20220330_3KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_3KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20220330_3KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_3KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20220429_3KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_3KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20220429_3KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_3KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20220429_3KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_3KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_3KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_3KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_3KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_3KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_3KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_3KO-glutamine-n-3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_4KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_4KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_4KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_4KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_4KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_4KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20230830_4KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_4KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20230830_4KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_4KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20230830_4KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_4KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_4KO-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_4KO-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_4KO-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_4KO-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_4KO-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_4KO-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_4KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_4KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_4KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_4KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_4KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_4KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20230830_4KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_4KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20230830_4KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_4KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20230830_4KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_4KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_4KO-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_4KO-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_4KO-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_4KO-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_4KO-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_4KO-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Blank1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Blank1.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Blank2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Blank2.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Blank3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Blank3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Blank4 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Blank4.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Blank5 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Blank5.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Blank1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Blank1.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Blank2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Blank2.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Blank3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Blank3.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Blank4 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Blank4.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Blank5 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Blank5.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Blank1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Blank1.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Blank2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Blank2.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Blank3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Blank3.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Blank4 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Blank4.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Blank5 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Blank5.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Blank-1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Blank-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Blank-2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Blank-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Blank-3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Blank-3.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Blank-1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Blank-1.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Blank-2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Blank-2.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Blank-3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Blank-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Blank-1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Blank-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Blank-2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Blank-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Blank-3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Blank-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Blank-4 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Blank-4.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Blank-1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Blank-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Blank-2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Blank-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Blank-3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Blank-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Blank-1 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Blank-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Blank-2 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Blank-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Blank-3 Sample source:Cultured Plasmodium falciparum | Sample type:Blank | Treatment:NA MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Blank-3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Parental-glucose-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Parental-glucose-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Parental-glucose-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Parental-glucose-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Parental-glucose-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Parental-glucose-3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20211215_Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20220330_Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20220429_Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20230830_Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Parental-glutamine-1 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Parental-glutamine-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Parental-glutamine-2 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Parental-glutamine-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-Parental-glutamine-3 Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-Parental-glutamine-3.mzML SUBJECT_SAMPLE_FACTORS - 20211215_QC1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_QC1.mzML SUBJECT_SAMPLE_FACTORS - 20211215_QC2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_QC2.mzML SUBJECT_SAMPLE_FACTORS - 20211215_QC3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20211215; RAW_FILE_NAME(Raw file name)=20211215_QC3.mzML SUBJECT_SAMPLE_FACTORS - 20220330_QC1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_QC1.mzML SUBJECT_SAMPLE_FACTORS - 20220330_QC2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_QC2.mzML SUBJECT_SAMPLE_FACTORS - 20220330_QC3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20220330; RAW_FILE_NAME(Raw file name)=20220330_QC3.mzML SUBJECT_SAMPLE_FACTORS - 20220429_QC1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_QC1.mzML SUBJECT_SAMPLE_FACTORS - 20220429_QC2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_QC2.mzML SUBJECT_SAMPLE_FACTORS - 20220429_QC3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20220429; RAW_FILE_NAME(Raw file name)=20220429_QC3.mzML SUBJECT_SAMPLE_FACTORS - 20230804_QC-1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_QC-1.mzML SUBJECT_SAMPLE_FACTORS - 20230804_QC-2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_QC-2.mzML SUBJECT_SAMPLE_FACTORS - 20230804_QC-3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20230804; RAW_FILE_NAME(Raw file name)=20230804_QC-3.mzML SUBJECT_SAMPLE_FACTORS - 20230830_QC-1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_QC-1.mzML SUBJECT_SAMPLE_FACTORS - 20230830_QC-2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_QC-2.mzML SUBJECT_SAMPLE_FACTORS - 20230830_QC-3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20230830; RAW_FILE_NAME(Raw file name)=20230830_QC-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_QC-1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_QC-1.mzML SUBJECT_SAMPLE_FACTORS - 20240206_QC-2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_QC-2.mzML SUBJECT_SAMPLE_FACTORS - 20240206_QC-3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_QC-3.mzML SUBJECT_SAMPLE_FACTORS - 20240206_QC-4 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240206; RAW_FILE_NAME(Raw file name)=20240206_QC-4.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-QC-1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-QC-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-QC-2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-QC-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0227-QC-3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240315_0227; RAW_FILE_NAME(Raw file name)=20240315_0227-QC-3.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-QC-1 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-QC-1.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-QC-2 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-QC-2.mzML SUBJECT_SAMPLE_FACTORS - 20240315_0304-QC-3 Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA MSRunID=20240315_0304; RAW_FILE_NAME(Raw file name)=20240315_0304-QC-3.mzML #COLLECTION CO:COLLECTION_SUMMARY Each sample represents metabolites extracted from 1E8 Plasmodium falciparum CO:COLLECTION_SUMMARY infected human red blood cells (iRBCs). After treatment, the iRBCs were washed CO:COLLECTION_SUMMARY with cold PBS and metabolites were extracted using a 90% methanol solution. This CO:COLLECTION_SUMMARY solution was evaporated under nitrogen gas flow, resuspended in water plus CO:COLLECTION_SUMMARY chlorpropamide as an internal control, and run on the ThermoFisher Exactive CO:COLLECTION_SUMMARY Plus. CO:SAMPLE_TYPE Cultured cells #TREATMENT TR:TREATMENT_SUMMARY Magnetically purified Plasmodium falciparum infected human red blood cells TR:TREATMENT_SUMMARY (iRBCs) were cultured for 2.5 hours in standard RPMI media lacking normal TR:TREATMENT_SUMMARY glucose or glutamine but containing radiolabeled glucose or glutamine TR:TREATMENT_SUMMARY respectively. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Dried metabolite residue was resuspended to 1E6 former parasites per microliter SP:SAMPLEPREP_SUMMARY of water (usually 100 microliters) containing 1 micromolar chlorpropamide as an SP:SAMPLEPREP_SUMMARY internal control. These samples were then run on HPLC-MS #CHROMATOGRAPHY CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Waters XSelect HSS T3 Column XP (100 x 2.1 mm, 2.5 um) CH:COLUMN_TEMPERATURE 30°C CH:FLOW_GRADIENT 0-5.0 min: 100% A, 0% B; 5.0-13.0 min: 80% A, 20% B; 13.0-15.0 min: 45% A, 55% CH:FLOW_GRADIENT B; 15.0-17.5 min: 35% A, 65% B; 17.5-21.0 min: 5% A, 95% B; 21.0-25 min: 100% A, CH:FLOW_GRADIENT 0% B CH:FLOW_RATE 0.200 mL/min CH:SOLVENT_A 97% water/3% methanol; 15 mM acetic acid; 10 mM tributylamine; 2.5 µM medronic CH:SOLVENT_A acid CH:SOLVENT_B 100% Methanol CH:CHROMATOGRAPHY_TYPE Reversed phase #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:MS_COMMENTS .raw files were converted to .mzML files using MSConvert softward of the MS:MS_COMMENTS ProteoWizard package. The .mzML files were processed using El Maven software for MS:MS_COMMENTS peak picking, alignment, and annotation. MS:ION_MODE NEGATIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS blank-subtracted peak area MS_METABOLITE_DATA_START Samples 20240206_2KO-glucose-1 20240206_2KO-glucose-2 20240206_2KO-glucose-3 20240315_0227-2KO-glucose-1 20240315_0227-2KO-glucose-2 20240315_0227-2KO-glucose-3 20240315_0304-2KO-glucose-1 20240315_0304-2KO-glucose-2 20240315_0304-2KO-glucose-3 20240206_2KO-glutamine-1 20240206_2KO-glutamine-2 20240206_2KO-glutamine-3 20240315_0227-2KO-glutamine-1 20240315_0227-2KO-glutamine-2 20240315_0227-2KO-glutamine-3 20240315_0304-2KO-glutamine-1 20240315_0304-2KO-glutamine-2 20240315_0304-2KO-glutamine-3 20211215_3KO-glucose-1 20211215_3KO-glucose-2 20211215_3KO-glucose-3 20220330_3KO-glucose-1 20220330_3KO-glucose-2 20220330_3KO-glucose-3 20220429_3KO-glucose-1 20220429_3KO-glucose-2 20220429_3KO-glucose-3 20230804_3KO-glucose-1 20230804_3KO-glucose-2 20230804_3KO-glucose-3 20211215_3KO-glutamine-1 20211215_3KO-glutamine-2 20211215_3KO-glutamine-3 20220330_3KO-glutamine-1 20220330_3KO-glutamine-2 20220330_3KO-glutamine-3 20220429_3KO-glutamine-1 20220429_3KO-glutamine-2 20220429_3KO-glutamine-3 20230804_3KO-glutamine-1 20230804_3KO-glutamine-2 20230804_3KO-glutamine-3 20230804_4KO-glucose-1 20230804_4KO-glucose-2 20230804_4KO-glucose-3 20230830_4KO-glucose-1 20230830_4KO-glucose-2 20230830_4KO-glucose-3 20240206_4KO-glucose-1 20240206_4KO-glucose-2 20240206_4KO-glucose-3 20230804_4KO-glutamine-1 20230804_4KO-glutamine-2 20230804_4KO-glutamine-3 20230830_4KO-glutamine-1 20230830_4KO-glutamine-2 20230830_4KO-glutamine-3 20240206_4KO-glutamine-1 20240206_4KO-glutamine-2 20240206_4KO-glutamine-3 20211215_Parental-glucose-1 20211215_Parental-glucose-2 20211215_Parental-glucose-3 20220330_Parental-glucose-1 20220330_Parental-glucose-2 20220330_Parental-glucose-3 20220429_Parental-glucose-1 20220429_Parental-glucose-2 20220429_Parental-glucose-3 20230804_Parental-glucose-1 20230804_Parental-glucose-2 20230804_Parental-glucose-3 20230830_Parental-glucose-1 20230830_Parental-glucose-2 20230830_Parental-glucose-3 20240206_Parental-glucose-1 20240206_Parental-glucose-2 20240206_Parental-glucose-3 20240315_0227-Parental-glucose-1 20240315_0227-Parental-glucose-2 20240315_0227-Parental-glucose-3 20240315_0304-Parental-glucose-1 20240315_0304-Parental-glucose-2 20240315_0304-Parental-glucose-3 20211215_Parental-glutamine-1 20211215_Parental-glutamine-2 20211215_Parental-glutamine-3 20220330_Parental-glutamine-1 20220330_Parental-glutamine-2 20220330_Parental-glutamine-3 20220429_Parental-glutamine-1 20220429_Parental-glutamine-2 20220429_Parental-glutamine-3 20230804_Parental-glutamine-1 20230804_Parental-glutamine-2 20230804_Parental-glutamine-3 20230830_Parental-glutamine-1 20230830_Parental-glutamine-2 20230830_Parental-glutamine-3 20240206_Parental-glutamine-1 20240206_Parental-glutamine-2 20240206_Parental-glutamine-3 20240315_0227-Parental-glutamine-1 20240315_0227-Parental-glutamine-2 20240315_0227-Parental-glutamine-3 20240315_0304-Parental-glutamine-1 20240315_0304-Parental-glutamine-2 20240315_0304-Parental-glutamine-3 20211215_QC1 20211215_QC2 20211215_QC3 20220330_QC1 20220330_QC2 20220330_QC3 20220429_QC1 20220429_QC2 20220429_QC3 20230804_QC-1 20230804_QC-2 20230804_QC-3 20230830_QC-1 20230830_QC-2 20230830_QC-3 20240206_QC-1 20240206_QC-2 20240206_QC-3 20240206_QC-4 20240315_0227-QC-1 20240315_0227-QC-2 20240315_0227-QC-3 20240315_0304-QC-1 20240315_0304-QC-2 20240315_0304-QC-3 Factors Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:2KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:3KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:4KO | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glucose Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:Parental | Treatment:glutamine Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA Sample source:Cultured Plasmodium falciparum | Sample type:QC | Treatment:NA acetyl-CoA 1C13 761155.2899 822074.6336 496954.1133 758861.5232 717680.3802 546151.4441 1119455.9400 1290484.9870 1081257.5450 1759746.1230 1645243.3790 1704401.9620 2089300.5720 2291622.9650 2008867.9350 2360289.1760 3058004.2580 2786533.1110 432187.8243 588300.0425 451819.9694 71749.1303 78510.5519 116230.3633 940967.7089 809513.8624 928964.0898 346361.8151 381529.5183 360528.3291 525084.5239 888996.3428 1083963.1420 144960.3366 108604.2735 97385.6026 1174250.2050 1277160.4080 1288397.2580 630691.0849 618041.7518 491368.8884 335953.1108 319798.7427 276008.1080 331338.6644 262681.5343 282995.8537 716090.8476 710145.5697 399771.3282 640792.3525 719608.1168 729176.6488 633877.1739 619998.4653 605211.1762 1493676.2620 1626984.9610 1351198.4890 909516.6365 1183225.8540 994145.2731 209222.7600 214798.1259 381633.7630 580899.2078 695156.2417 609827.6342 457759.0894 467941.3123 367184.8159 526909.3266 653388.5995 508795.1606 533498.6159 648670.4429 681811.9121 748486.9564 811083.5439 1256542.4040 840536.4399 792126.4423 919293.8040 916866.1683 1676007.9840 2347245.9330 442987.5391 599028.2243 584229.8442 1317715.9630 1240914.2860 1597154.4130 866799.9519 924709.3695 970820.0086 1112561.9180 1437403.5430 1599830.3030 1765045.2940 1740986.0470 1921989.3670 3117500.0860 3665265.8050 3007272.3400 2467796.1950 2798014.8430 3211654.1710 890423.8170 900354.7996 942692.9387 271858.2014 248634.7654 248070.0380 1093352.2550 996094.0773 989419.9703 550119.2644 531284.8756 565014.7166 747317.0611 712763.0286 657127.2145 1084607.9970 1135685.7770 1209676.3790 1190489.5250 1766214.6550 1712808.4040 1862169.7860 1937710.0550 1935154.8910 1904254.6800 acetyl-CoA 2C13 594635.8556 497097.6872 368932.0459 811070.8359 768088.1350 583935.6655 763177.4460 931258.3635 763544.0507 317327.7466 352745.1702 303455.3786 436624.9860 484038.3600 437944.7835 450891.5859 574252.3574 536598.1265 354765.1206 474888.7218 337410.7755 23035.1176 30415.3730 49208.8446 711603.8853 785466.8357 764629.2633 382603.9337 399650.9868 425151.6051 73579.9719 167341.3878 175798.2422 17635.6977 365.9448 10652.8450 219165.8773 225375.3835 250707.2656 178202.2113 197878.7366 142351.1427 368139.8947 247564.7670 301221.8804 333867.9515 228350.5969 214118.6127 366993.9136 308578.2282 196000.3554 204922.1509 209191.7372 210803.8018 173348.2120 170190.8080 134367.7156 277583.7271 242055.0223 231281.0289 2313920.8040 2842150.4890 2532274.7690 398003.9644 428116.0948 684995.7011 1185389.3690 1555432.6820 1274990.1340 1160588.8920 1203623.1040 984485.4880 1457985.9040 1708359.5470 1348810.0870 1614465.5220 1856140.9390 1838652.7010 2747642.5560 3129078.1490 4859334.7430 2732757.5750 2450953.4330 2901460.3500 226546.3694 445753.5187 676765.0724 106618.1869 130285.9601 121607.3228 335284.4044 326565.0174 364325.5473 387637.4918 436818.3680 460810.7122 442595.4810 544539.6484 574100.7878 353896.5294 323422.6631 445003.3900 879055.9146 1029070.4430 823805.9334 644292.7396 680094.2494 832142.9960 734999.4360 757277.3673 776247.8336 178372.6378 163485.3620 173793.5957 689229.7297 618569.4158 641066.5633 475417.5306 436574.8075 413825.2626 591481.3964 602721.6609 593402.4647 535880.0853 583548.8312 602598.2740 586612.3599 1344415.3420 1418010.3430 1429214.6510 1307947.3620 1217898.3320 1203828.8140 acetyl-CoA C12 3037506.2420 3137421.7300 2000555.7880 2755243.5990 2565173.8980 1984715.9550 4025024.1360 5210775.0100 4083409.0770 6706379.1770 6135331.9000 6542597.6200 7687682.5270 8389010.5040 7435712.4550 8582009.0710 10889552.2900 10091730.7000 1674820.4150 2217096.9320 1555144.5280 312503.3072 297935.6906 522967.0864 3664961.9560 2995899.3380 3611813.2600 1342832.3900 1455775.7520 1326428.1840 1970183.4110 3641714.7430 4030030.1460 545643.3825 390203.3332 427212.5758 4584922.1060 4871952.6290 4963539.6540 2577946.5190 2413699.6190 1954376.2860 1247883.5630 1206110.3350 1195008.0540 1442037.3840 1251936.2610 1156772.7320 2465974.5240 2374092.9760 1637232.7310 2538150.1850 2802432.5440 2843702.4290 2414335.2640 2240644.7450 2400944.1710 5964918.4620 5773582.6330 5097345.9350 3227411.3930 4296140.9530 3834341.4830 768497.6258 959082.1586 1414458.2310 2093589.1430 2474990.1570 2330470.8350 1646093.1220 1738760.3650 1375556.5640 1946753.3360 2279491.3850 1787064.4630 2109750.8940 2262786.1380 2416634.9550 2418483.3470 2701874.8210 4245067.7150 2926247.7390 2705272.7160 3208071.7510 3472825.5430 6378099.3130 9212436.0610 1754459.4420 2312336.9280 2315925.1860 5049456.6810 4735004.1240 6108740.6280 3320317.2880 3540419.5310 3550978.8260 4340043.1230 5136071.5270 5983219.3050 6851701.6130 6549753.6870 7156836.5750 11610696.8000 13848090.2400 11319310.4000 9549308.8910 10647118.8300 11693087.5900 3261683.0030 3487154.2290 3533297.3380 1090819.1300 994071.5212 943688.7024 4213977.5990 3822070.7780 3803512.9230 2325077.6340 2117845.2500 2135569.2220 2756212.9460 2774183.5760 2604733.4350 4150265.9530 4235292.2320 4454698.1540 4487687.7380 6523266.4540 6473098.1510 7059752.3200 7355019.7740 7355212.9840 6924381.2710 a-ketoglutarate 1C13 9293144.2370 10650287.7600 12590284.3400 9703470.7680 9225177.2330 9529955.0190 10646596.1600 11077714.1800 12491751.3200 5176864.4740 5391937.0000 5444227.1540 3518383.7780 4010142.4670 3843341.3460 3035840.6160 4021840.7900 3589374.8840 972886.4396 1347923.8030 1086005.7600 468308.2022 308925.5400 635752.5983 3193399.2340 3982851.1130 3165112.8320 7309604.8960 6879243.4440 7324180.4530 607233.5439 1175018.4990 1459961.3570 875516.1198 412441.3790 722199.2466 2828171.7330 2457778.3840 2678941.2480 2857759.9130 2565932.1520 3008592.4260 9796734.0570 10262046.4900 9678869.0080 18744615.4500 20476057.1600 20219839.0900 12932825.6300 11706434.4800 13834773.5600 4852781.2410 4554958.5360 4438734.7650 8478967.5430 8080394.6970 8703244.7460 5287264.0940 5407693.1870 5386189.2050 5904276.9900 5169714.5320 5370366.4030 988845.1818 1117704.8490 1497415.3330 1939586.7040 2414982.3620 2514066.9750 5502666.2590 6067953.1100 6366942.1900 12730420.8000 13346383.6000 13377113.8900 17704771.2200 17298387.1500 16697964.5400 10176725.9200 9686852.0070 11671597.5000 9939682.8440 9745621.5170 10002502.2900 3214873.9700 3858881.0960 5214460.8680 1478698.5740 2017035.0290 2061578.4640 3122993.7070 3345675.4680 3653676.5410 3090678.0400 3476083.5710 3009132.8290 7221727.5900 7811589.8000 8654011.4460 5300344.2580 4692125.2210 4774190.8550 4025895.2910 4188954.5300 4272670.3280 3827360.5510 3867076.9420 4351546.6910 2650752.7660 2682443.2880 2671380.0580 1188887.4890 1119829.0720 994210.6008 3266616.5530 2955333.2450 3115833.8810 6197693.1600 6080815.1390 6214748.4450 12050008.0300 11998769.3600 11567794.8900 9153738.4450 9094408.9330 9407157.1080 9534322.1950 6685346.8530 6794391.9780 6843804.7250 6729558.7140 7013931.9720 7012550.3810 a-ketoglutarate 2C13 738437.9284 944027.8760 1058378.7930 869828.2211 860105.5630 958826.6796 936964.5575 1089091.9120 1279737.9760 108715.1188 23304.1101 65894.7834 44883.1756 96227.4613 4042.2302 28720.6758 62707.7525 50597.5054 18420.1716 8587.8450 36267.1251 28177.3916 19226.8743 24365.2920 154214.5925 173203.8289 171070.9289 205179.3808 195568.3225 253364.9868 5365.0397 3043.1516 8273.6501 28177.3916 28177.3916 28177.3916 64109.9191 57254.0679 91716.3229 24498.3309 28093.6626 45289.4169 235856.5220 245678.2028 153275.1252 354631.0406 369189.5120 405055.9774 228919.1387 243820.6827 252276.6188 93986.4285 45613.8972 64578.3074 107727.0527 139080.0129 120810.6784 86384.8269 67095.1154 57275.6740 5077688.3590 4062115.4090 4243575.5940 777958.3767 832968.8668 896618.8097 1472975.9200 1742395.7530 1885773.8010 806058.1163 1018320.5290 1129000.6440 3431958.3880 3500609.9480 3426893.5080 9245905.6330 8623301.6830 8138022.8240 6923021.9870 6701450.9190 7892160.7070 7506065.9480 7296779.9520 7023055.1150 140260.4833 172252.7505 179872.2951 38220.9168 407.5977 32878.1609 102825.1675 101822.4732 41340.1387 49258.8239 49512.2692 37601.5744 81827.5720 147501.4638 171359.1838 231724.0344 215006.2926 173908.3802 153640.2426 144311.6510 189069.7240 161052.7124 157788.7109 168187.0607 924193.1133 863719.9407 918121.2831 267547.9156 114850.7719 212092.1210 537949.4549 410378.6270 479792.6509 230336.5651 273665.5002 197368.1985 974603.4102 1008465.2740 844475.2820 1592412.0260 1604646.2020 1788649.5870 1682414.5480 1920628.4240 1954750.4710 2035854.5760 2003923.9800 1979601.1340 1940847.1510 a-ketoglutarate 3C13 1265.9500 8885.9565 8885.9565 16318.3871 24288.6076 16116.8094 19101.9895 6940.7497 181009.6969 250096.9520 228824.5354 210106.9796 208541.6441 232981.0907 351780.4558 459340.9022 400815.5167 2286.0140 4465.3770 2286.0140 3890.9095 24949.8091 50291.0157 62724.7461 3099.2721 6985.6486 8411.3248 222900.7004 182521.3385 181481.5995 67790.7339 14941.5185 33797.2579 13179.4175 8885.9565 196.2435 8885.9565 84958.6025 96616.5650 92669.9835 110414.1592 120330.4590 156586.5392 33103.1289 47219.6648 54626.2999 200664.3522 150474.8431 169330.7033 2286.0140 2286.0140 12440.0826 52581.9869 66992.3163 59328.6747 13089.6876 16480.0984 11762.2599 49681.4325 56524.0429 39372.3090 231062.9109 327062.5496 316068.6734 321692.4288 303600.6740 378108.9996 361024.9842 317444.3194 346707.0156 521279.2535 622570.6893 795798.5436 159103.5631 276223.7012 212795.8296 271790.9025 278434.4135 155514.6908 77924.7403 130182.6822 66062.3648 361965.4505 291153.3632 343764.3257 1686547.0640 1316292.7030 1574703.8860 1027256.2070 1073079.9790 1182649.7500 1510799.6420 1499908.7710 1626780.2020 167140.6823 204769.1533 208524.2948 21595.5674 32314.3419 27219.0658 130707.7795 118132.3746 99115.5082 19562.9860 45541.5852 31430.9592 123194.2550 85914.2128 183881.0684 267814.6453 312883.2562 347968.0076 309048.1532 426130.6832 419626.5924 408386.7979 591536.9790 664175.9571 557496.6116 a-ketoglutarate 4C13 27343.9315 70030.5044 40173.4588 158616.2879 121827.1935 152280.5372 142910.4378 171381.1530 191878.2588 8932181.7810 8810523.5370 9390099.5200 5460653.0140 6085900.5910 5971167.0320 7464106.9150 10138220.0300 9022363.8160 2688.1066 2700.6239 2700.6239 8207.5331 3486.0062 9012.8371 108621.5946 68450.2524 69694.0996 11650.4252 26486.8620 34741.2159 433033.4940 691489.2705 918436.5023 365357.1621 214297.0656 336111.2282 3194033.8040 3121601.4720 3277848.1220 4373150.0630 4163133.0060 4602971.2280 1279.3984 1279.3984 1279.3984 7464025.1180 7549011.7980 7264999.0300 12226546.9900 11824766.6900 12947286.0900 8794833.5630 8978075.9630 9130284.5590 839317.6815 673981.1999 744107.2901 185088.5891 299155.6964 258638.9904 581468.0436 732583.5383 699329.2806 283422.3721 341155.2701 316861.3204 568882.9585 626276.4303 633296.0783 931245.9607 673946.1631 736657.6233 1018473.3620 988649.1324 1249419.3600 1178065.6500 1098061.2240 1067026.5820 2151857.8880 2647671.2350 3230529.5020 900900.2374 1226981.6630 1221966.0360 2852458.9200 3097374.4400 1780795.0750 4103492.0500 4604477.6650 4059626.6320 8760283.7320 8464502.8950 9863180.0360 12708246.6200 11107690.1700 11954886.1800 5453244.9450 6106115.8600 6399239.8640 6450357.9570 6756410.4050 7231682.3100 934467.1694 966015.4553 1019612.3580 420390.9992 418404.2032 407820.2410 1679187.9580 1661969.5460 1777663.1940 2913425.7710 3076419.5950 3133603.0530 5407248.9030 5622551.5200 5029935.5130 5025477.8490 5218759.1830 5142983.8440 5308692.9770 3409485.9550 3503678.1960 3495983.5070 4415742.6550 4514783.9570 4630286.9400 a-ketoglutarate 5C13 20947.4272 10241.0529 26247.1564 27520.9406 39021.4282 52944.6412 41290.8658 29958.8644 68377.5259 220403577.3000 215586937.3000 227617930.3000 134225860.8000 150535112.4000 144413092.4000 182258117.4000 247358598.5000 226396993.1000 60866.5900 15071.9414 6053.8422 4960.8512 6774.9727 5916.0165 6774.9727 13837364.0600 24483166.6100 30196190.6100 15418178.8500 9016373.3380 12452468.9300 88006215.8200 86921519.5100 87841107.4100 113698263.7000 101481871.7000 118473491.6000 6774.9727 6774.9727 6774.9727 21301.2846 11602.9026 23120.9276 186041013.0000 183807548.3000 184030888.0000 288886876.8000 290781528.8000 317391112.1000 217223329.4000 220846749.9000 222919291.4000 499871.2993 338830.9579 351497.6964 77765.7568 115057.3342 120414.8348 250162.3880 301833.3413 265800.3778 28153.2875 40826.6696 78279.3202 141250.7537 57713.6636 171588.4280 409688.5938 311623.7638 391055.1767 469372.5942 381425.1202 524795.0261 553919.2419 450737.2453 521255.4345 71385124.9900 84940364.6500 106414604.4000 33518791.9100 41761495.7900 40820837.3900 75440459.3400 83292290.9400 48694827.5500 101921936.7000 112962321.4000 102424722.9000 212320905.4000 214337017.5000 248118030.4000 311255437.3000 274624294.2000 299368567.8000 139635581.0000 148186163.3000 155830013.1000 158969891.5000 165335203.7000 176848958.4000 27741937.8900 26992489.2200 27845000.6400 13688612.2600 11924690.6200 13058704.6800 43237402.3700 40816996.2600 41447896.9000 73147030.2800 76643532.1600 77909404.2900 130475676.2000 130301309.6000 124413979.7000 120854651.3000 123806713.7000 126769808.6000 128918760.5000 78642310.6000 77258586.1600 76454359.7600 101254823.9000 106323530.8000 107813663.4000 a-ketoglutarate C12 157158225.8000 181974125.9000 212426086.7000 161871055.4000 156393147.7000 157440611.3000 179500035.6000 194482516.9000 214645753.4000 91057756.2100 89124119.2100 91738574.6300 59720208.8700 67445952.4500 64463641.3400 50994431.7600 70426216.7000 63440401.6600 15696425.0200 20577415.8200 17562074.6200 8415995.0580 7343843.9280 11754104.0500 53818588.2900 66268250.0300 53789444.7400 129081116.3000 115174732.9000 123844939.4000 9347487.9860 18660570.6900 21899072.2100 15560034.4900 8552314.9480 12582273.9800 46572484.8500 40648013.4800 42269685.8300 51823228.3200 45830690.8700 51681533.6200 169099504.3000 178669140.6000 167920857.3000 315252700.7000 339196949.3000 351252873.3000 219954284.8000 199246819.5000 234126386.4000 81497221.5100 81178585.4900 79111884.8000 139725246.0000 143616958.3000 147287446.1000 90713868.9800 89991948.8900 92059750.9000 94706476.8600 85316106.1300 87373765.5000 19741829.0700 21154251.7600 28634214.6100 34954731.2200 40705001.1500 40226477.2900 93742798.7400 102303849.7000 108991922.5000 219431847.0000 231018946.5000 234451671.6000 298890612.8000 290610266.0000 285074139.2000 167570061.4000 164401569.7000 194866394.5000 167523808.2000 167857255.4000 165082443.0000 51868692.8700 63222162.6300 82692177.2300 26511802.3200 34772266.9700 38197197.4500 49396001.9400 56070257.5300 61215782.6700 54089986.4600 59185052.0000 52026066.0600 123568062.2000 132633889.3000 150551736.6000 90042427.6500 80558832.8300 82998568.4900 66606743.2500 70328306.8000 70802029.5900 67555813.3000 70057021.9300 74367786.3500 43252891.3000 42040916.3500 43536328.0700 21115629.0100 16404894.7200 17943575.5900 54586345.1800 48143227.1800 50334245.1500 100880902.1000 106967605.2000 109160064.0000 206384981.3000 206897853.2000 197515031.3000 155769678.4000 155598482.3000 158231307.3000 161270677.4000 112109768.7000 114202655.4000 117321681.6000 114830761.5000 122131743.0000 120115438.2000 citrate/isocitrate 1C13 4929383.9450 7124860.4630 5003661.0920 6165782.2070 9298279.2810 11939605.8700 12138528.2100 8817492.8110 9958274.9780 12320242.3600 11722026.8100 10757676.6300 2872763.8270 3897365.1700 2497845.9200 633067.3817 30920085.1900 4991285.8010 10124580.2800 7226021.7860 1238264.8550 1571749.2550 1298985.1470 1216825.9150 3257845.0770 5518118.3020 7927661.0810 3193482.9810 391333.1459 30920085.1900 6736090.8960 81796704.4200 5358292.3250 2433115.6690 2440151.1130 2497145.4510 1286820.6510 1744636.0530 1149010.1030 344813.2047 251090.7934 512430.0280 2502611.3980 2151161.5970 2096241.5680 347025.4261 453160.2526 82592.4657 9142459.3630 14694160.5100 11146104.2300 1453859.9450 30920085.1900 6838306.8880 2650897.0700 4895201.4320 5630456.8800 2063516.4140 1876974.5790 1844707.0550 344176.4470 275370.4341 413928.2270 6303821.0380 8218614.1470 10436259.2000 7487804.3610 8654908.3470 10076173.3800 12468733.3800 16069125.4300 20767959.5900 124048.3525 1631019.3670 3788905.7330 1940713.7710 12116607.7300 7545275.0540 4387321.6120 4672512.2660 3930834.6270 728353.7349 748818.1338 1055194.8250 14418882.5100 20032584.2400 15569708.5700 14288332.9500 17075018.9900 16231363.8800 9231690.0290 8175557.9070 8130862.3750 4002679.5060 30920085.1900 40448.2222 4184500.8600 4974729.3030 9288604.4010 2342731.8010 2707610.1610 2511701.6740 554555.4010 575010.0126 360421.1208 6429571.7230 8508759.7640 9726387.7070 9176590.9810 9493029.2470 8921597.5960 citrate/isocitrate 2C13 217036603.7000 141346476.5000 130984025.1000 119341988.0000 161106705.0000 144196388.7000 8410109.0050 42415010.8000 45558042.8300 15297864.2100 31502735.8200 30134057.8800 50742691.0000 75077751.5900 52464534.3200 221485.3987 148514.3608 162970.0567 14143891.7600 13592434.5200 13190865.5100 9672544.1970 9605472.2330 8793622.4410 514690.4864 28773.3774 2408.4308 183883.4600 162304.5333 78628.0266 150616.8905 1921925.7710 121597.8974 1213435.1200 1121105.8490 1213435.1200 5120507.4820 6161095.6030 5896002.8880 2143570.1310 1530321.7650 1770931.1300 1213435.1200 1213435.1200 1213435.1200 438196.8924 59917.1890 1015703.3070 193092713.5000 264050695.8000 221554144.1000 893398.9432 3461612.0850 2701757.0470 40321427.3800 44289684.4000 45154706.1600 26873708.6000 26628340.1500 27768217.0500 6548941.0770 6094017.5060 7207659.6380 183007345.9000 275717217.6000 320175669.7000 185251377.4000 194966490.4000 220234585.9000 679581.7424 336747.0458 2712610.5050 764024.2169 764024.2169 72514.9239 73558.5908 441823.7816 281292.6611 1213435.1200 1213435.1200 1213435.1200 1203022.7130 413966.4673 1322559.7910 3910655.5380 18160429.1900 30073933.1100 15382980.9300 1388192.1530 30184706.2900 61532597.4300 59181655.1800 61350103.7200 225759.7614 560144.8135 835530.8263 11970911.4900 14319665.6000 15540159.0000 5661716.4670 8021128.5960 6603571.0130 1762761.8710 2538243.9280 2381879.1570 65634981.3600 80680834.9700 94845127.7900 70998318.9300 71193465.5900 74712511.7700 citrate/isocitrate 3C13 11228814.2400 9154497.8680 7811630.2470 7449858.4370 10229406.3800 9703588.0250 3381501.7560 4700741.0440 4891704.3730 6001103.8890 6467499.5940 5919411.4120 2986627.9930 4423084.8190 2946532.0000 26809.1823 18324.8921 1170745.7520 1174849.4300 1127108.3390 438400.3992 318045.7171 336020.6973 7644.0348 21923.8088 14830.5480 27371.4804 10974.7068 8110.8065 8110.8065 184133.8776 350366.5491 312059.4997 190049.5258 172286.6299 297618.1391 8110.8065 8110.8065 8110.8065 16993.5608 8865048.9690 12431861.3800 10560553.8400 68130.2320 209386.0643 146687.6206 2303336.7210 2528590.0430 2540652.5160 1020494.5450 984476.3908 1083643.0500 459970.2974 381333.6381 384580.8831 10396790.4200 14586015.0500 16944858.1500 10076277.7400 10618515.9600 12268578.6300 1115892.3020 1154596.7700 1659354.2740 49715.1605 65420.2454 78044.4337 183411.3201 165654.2502 151293.1844 21923.3669 45667.3342 24804.5443 32550.3487 31100.3840 31220.7652 4664815.4640 7254767.9940 6257767.2460 6134754.8260 6382095.0810 7365086.6430 3259161.8190 3054611.1750 3433943.5010 8351.8909 21925.2068 98843.4320 820896.6558 845641.8235 1007458.9160 91800.9054 159659.8363 123130.4196 100462.6135 188963.3425 230228.9694 5094044.6740 6605602.4320 6957032.6510 5883618.4010 6303698.1460 6422503.7390 citrate/isocitrate 4C13 1808027.6060 9764202.4770 5791079.2290 7011098.2150 12538543.6700 11465457.9600 24862470.3500 17075727.4500 19270248.5500 32256420.7800 33330102.7200 30625555.1300 1312025.2920 2478264.0740 1405805.4730 44046.4613 12659.8329 12659.8329 550422.3925 621132.0804 462810.4929 198169.6459 226374.6624 233189.4928 548165.2154 823736.0052 945620.6920 32138.9241 12659.8329 12568.7652 448237.6069 349912.3016 406767.9031 306999.4831 300686.0799 238555.6892 981677.2486 1110998.6400 965521.3054 317482.5426 232052.9120 252532.3877 457282.0564 422149.4859 375488.9954 363904.7785 341425.3805 278627.6562 7268978.7090 8619204.8570 7965926.7240 113314.7327 231441.7523 99459.9247 2051672.5310 2201051.0520 2138136.3190 984346.5536 1031789.9220 1026187.6210 270889.0847 219457.1007 181777.6594 6196938.6790 7750002.5950 8939139.2560 8637414.8660 12053433.1900 13306351.1400 10036696.8100 11485330.0100 16176018.1500 316276.1549 479438.3406 418131.9541 1329715.0280 1412626.9560 1010592.6930 1283850.3990 1284165.5620 1124322.0530 598772.9554 613081.8386 575523.1510 30926346.7800 39387419.1800 31583064.6700 33402128.5000 40542105.3300 38859236.8300 5046353.0250 5136022.3380 5203618.4700 76779.8986 107004.6917 130416.7605 885957.3371 1063291.4810 1189849.9900 559492.3068 633181.3034 509773.2972 278578.8033 325212.6285 320869.4154 9932557.1440 14016337.8900 15640590.5600 17730208.7600 19905650.1600 18381139.8700 citrate/isocitrate 5C13 72465173.4000 57007198.7400 42509545.3300 38639966.7400 66427979.8200 60409209.3900 10123576.7100 15688681.8400 15386853.0200 12295807.4200 17966209.7700 15171191.4500 20846844.1900 30252209.7800 21384429.7000 172591.4412 100276.9349 80703.6935 8381735.7640 9538419.2700 7928495.5490 4997761.3270 4440782.3010 5222924.5370 2305901.7470 2697503.8700 3617891.2860 306128.1353 107998.0089 192086.4482 3381040.7040 2893268.9860 3923434.9690 3923786.3390 4072610.2230 3291374.8050 2902621.7470 3748559.7120 3273986.0350 877509.2390 707042.4723 749379.1426 4191516.6400 3541216.1050 3834119.7180 2436151.4180 2327454.4940 2225893.0870 52272190.2900 69832241.3700 57378282.9400 552114.7860 2208022.5860 1306478.6220 25045174.8000 26587033.6300 27737566.9200 12621891.9200 12521147.7200 13445256.9000 2140620.3280 1928707.1300 2295897.3140 70435689.3300 98536373.3000 119656316.6000 69904744.6100 70234935.5400 80722343.5700 38053577.5900 44577049.2800 59486858.1700 1652343.5480 2416752.7210 2626281.7920 10026275.2900 10400442.0600 7910031.0940 8932537.9140 8421808.1120 7796711.0880 3867518.1650 3671052.3130 3879059.3540 41557051.4500 59989166.2800 54553817.8700 53070060.8100 59168915.2700 63741912.1000 29469851.9700 29099100.3000 30480462.9100 383304.2626 583234.7782 1088781.0290 10032772.4800 12054154.4900 12367901.6700 5144424.4430 6820561.9030 6184479.9750 1785880.5610 2108378.0930 2229722.9850 30967012.3700 41791401.0200 45533369.8700 38235783.3700 41667597.5500 38968980.8900 citrate/isocitrate 6C13 970783.4367 654031.2306 536352.4791 620643.4668 1028011.8460 857177.0917 144969.8311 327501.8295 286151.0400 275394.4316 606798.2076 401217.2403 99182.4282 125459.3317 179623.8750 1884.8802 1884.8802 9442.0685 33430.5987 55720.5465 194835.5713 126683.7204 140546.7150 18760.8692 24662.9286 24662.9286 6065.2525 1884.8802 5977.2770 17431.7575 16704.4225 7990.2886 97505.1385 169417.0143 145479.1380 765579.1812 761740.6550 728954.8004 175081.7319 129244.7987 240757.8965 87740.4603 210697.6843 86074.5343 6439.2423 24649.0536 24649.0536 700611.9144 1048883.1540 733272.3849 1884.8802 26468.2692 6344.2117 325035.9345 367776.7655 418863.1724 287561.2756 228950.2352 229180.3885 45394.9966 24649.0536 19248.3241 1070220.9670 1620818.5150 2094411.3720 1429216.4490 1499540.9120 1886310.6800 318016.9920 204396.7921 382829.8909 4905.3619 20482.4786 7327.5339 6457.8625 17795.8203 235848.7511 183739.8899 240132.4438 28600.4331 59846.1379 37214.0097 397662.6203 713534.2990 479920.8505 571366.0954 818869.9301 844080.5172 224613.6284 230609.2708 265585.5941 10137.6465 6334.7958 16577.2522 37833.9092 91155.8939 61547.3144 229607.4513 315491.6572 303527.6366 11899.2006 92030.1540 81207.7917 372186.4846 464079.0143 599687.3375 536118.0335 550762.7418 696276.6828 citrate/isocitrate C12 72173235.0600 64744215.6200 31210075.7200 48165695.2300 86923711.0500 127002403.4000 190076020.8000 118770364.1000 134069740.3000 180853046.7000 162129261.3000 150527869.6000 20922153.1000 34475559.8300 20473923.4600 9660018.6860 452830907.9000 71859680.6200 142018854.1000 100726818.1000 18672897.8800 21894342.5400 14581768.0100 13207135.7600 42987798.9000 86079830.2500 111530072.8000 51369572.5200 15652376.5000 4909314.1740 98293771.9000 1205371667.0000 77017067.8600 33409699.7900 34737891.3700 34197337.0500 15490854.2200 19067274.9400 12617086.9800 2109324.7600 3786024.2310 2369433.6000 34828344.3000 28594031.1200 27789035.2300 3900836.0170 5349840.6630 2949908.1870 83227134.1100 143620495.7000 98023214.6700 21073181.8100 452830907.9000 113207328.1000 17406016.5800 62599163.9400 73711412.3500 20907719.1400 16633983.7200 17718300.7400 3594905.0820 1127354.5140 4376550.0990 29651805.0300 30212121.7900 49684402.6100 50938473.9500 68089947.7900 73688853.5200 180418925.7000 242809740.4000 298764091.1000 3160371.6780 26976476.7100 49281726.1000 17555109.0500 180572901.2000 104741410.5000 65754074.8600 70357353.0200 57901995.7600 12727326.4500 13456788.2500 14496731.5300 223802832.5000 293660301.2000 226159394.5000 211829727.9000 260212619.2000 234817169.3000 111338223.9000 101246875.8000 98151263.9800 61744730.5200 452830907.9000 3206198.1420 47734824.5400 63463599.3500 138971737.8000 33398097.6500 37222712.7300 38662477.5900 3181891.1810 6575431.0390 3807662.6280 68806302.5500 99454550.6100 112200561.0000 108498695.4000 120528109.6000 109686560.9000 fumarate 1C13 8130565.0950 7923056.4960 8241114.6340 4180957.6180 3745072.2710 3847252.0930 4363260.0400 5506890.0360 5414719.4060 7298927.6610 7509381.2620 7358055.6920 3696465.6880 3125789.9270 3500950.5170 3885047.9860 3896997.3380 4078254.7620 733648.0566 1069574.5250 793990.0215 602568.9132 628755.7898 661915.5106 4212568.9930 4388667.2800 4597283.6850 4098688.6510 3880863.7330 3877862.4530 497137.1270 1422820.0730 1506832.4860 647920.4664 407068.2955 600030.4812 4741503.8400 4146185.0300 4445835.7810 5094414.8040 5127241.9010 5627847.7060 4669580.9050 4930615.3250 4834535.4810 8696086.4120 8921292.3250 9657491.2930 5685464.6900 5516507.6390 5487253.4660 6597071.3430 6747584.2280 7325596.4010 10212118.0600 9755792.0320 11432685.1600 6374819.6270 6315016.7360 6591891.2660 2738181.0270 3127568.0760 3031090.1100 1252720.9170 1204878.6940 1391056.8840 3130583.9230 3318013.9380 3203146.1590 3075609.1740 3027571.3620 3255938.5380 5803722.0540 6986700.0920 6413737.2580 7324377.0500 8004690.1230 7544593.4380 3627994.6320 3986723.4290 4368858.4730 3568248.1220 3795648.8330 4702700.9480 2089954.1200 2684575.5840 3288815.3970 1390343.2820 1823797.1040 1884870.8760 4191690.8340 4700560.2810 4766568.8380 3889859.2420 3474512.4610 3413840.1490 7613161.9890 7218191.3780 8716987.7570 6124683.2680 6002404.6160 6643771.9480 3807433.8690 4714687.3230 4292230.5820 3438536.4540 3871679.1430 3673672.9900 1725337.4060 1748464.5670 1782943.4780 1141698.7950 1060500.4000 1078697.3870 3789568.0590 3985582.9460 4313510.6330 5099087.4510 5054351.9440 4905931.1500 8725829.2180 8385206.6950 7768576.0020 6566477.6190 6914599.3560 7056284.4170 7413783.6990 3833512.6300 4015481.3730 4190581.0730 4056099.1530 3923620.5340 4397728.9050 fumarate 2C13 1215222.1220 1111022.3920 1208476.6990 1206054.0710 1061051.0230 1079136.0470 1467205.9240 1865847.2240 1833506.0300 642041.7295 619820.8546 525129.5044 161575.9389 159313.5127 173135.2309 344370.4613 342384.5212 401321.4707 212197.1872 356034.8382 185188.3219 64088.5855 35615.7755 4144.6050 1802177.6670 1475630.4850 1622103.8430 21592.1183 77150.8675 41628.5537 138027.8704 138027.8704 138027.8704 48696.6203 35542.5822 25272.4569 1796576.1030 1818100.1740 1812035.9420 2421164.6940 2340069.5550 2253035.4630 1841329.9680 1868151.9890 1932940.8970 43566.3673 19349.8491 40040.9523 76594.4382 66678.5121 157501.2628 63534.1772 74288.9061 69748.5341 1233596.4130 1435590.4860 1426842.4070 353907.1770 242068.4012 468394.6406 1443545.4460 1373014.5590 1537891.5600 2029547.1170 2362196.8680 2150863.0130 3975293.7890 3967665.7780 4237658.0470 1907358.5580 2079716.8880 2268465.3830 2085133.5750 2294612.3720 2894348.0360 48580.1539 30393.7835 93079.5622 138027.8704 138027.8704 138027.8704 40474.9668 48641.2228 30314.0624 92617.1329 108478.5573 129917.8050 767521.3968 784051.5172 824548.5555 443917.0351 576534.9616 454237.8865 479449.9128 556079.1818 541372.7852 302973.5171 340597.7409 265690.7951 94452.8931 138027.8704 41106.7392 861143.5451 874646.6122 778114.2584 1245226.2320 1210630.4360 1073514.0550 1444430.8420 1425494.0980 1390761.1450 1473609.5880 893620.9438 953379.7631 1066110.0180 1200272.7160 1179998.6520 1246461.9350 fumarate 3C13 17438607.0300 16365682.9800 17546555.0600 21550092.8800 18830088.7700 19190786.5100 24731552.9700 27612659.9100 28085408.7200 6977724.7630 7316035.8810 6301578.6520 1938010.8620 1752622.6220 1995719.7610 4275596.9920 4359860.9310 4298094.3890 7316502.4740 9015156.8700 7381160.9600 5076598.2090 5161537.7260 6309272.3580 43707902.0000 48184816.8200 44652902.7700 36188608.1900 32406192.2200 35854892.7400 7507.4972 12461.7065 27590.1958 16144.9580 6470.8246 393254.2745 370146.3288 457823.6758 113708.7596 118793.6605 136598.9328 34451197.9700 37171694.1900 36751379.9400 50754924.1400 48809653.6100 53455654.1200 45546426.0100 45322031.0200 48310941.8900 20165.8755 27749.2572 20731.0372 95665.6856 136822.8983 92988.0791 2194.7203 2194.7203 9003.4985 15289085.6300 17891407.9400 16576268.5600 10748169.5400 10333793.1900 11828788.3000 29846696.5500 32391673.8000 31786701.5300 22598427.8800 21685956.0800 24438527.1500 33230924.5500 38608676.8000 34555415.7700 25332247.0100 24173562.9500 26995341.8400 20039529.8700 22612219.5800 24066649.7700 18779299.1600 20635261.7200 26821815.8100 569983.5268 755607.8662 880490.3633 319172.4404 372991.1833 392999.9706 906428.3927 943055.3505 468297.9083 325370.6117 340256.3150 265472.2570 779006.7625 829611.5312 949592.3169 4249053.4880 4359446.2860 4482674.8020 2184808.3830 2724567.9510 2289598.9850 2469739.7250 2664940.9580 2318999.2470 5698887.2490 5390525.6710 5432462.3640 4637649.4980 4252080.5150 4197027.7280 19140967.3700 19156195.8000 19873390.1000 16012426.2800 16251721.6300 16412008.1800 22976644.0800 22487055.8100 20987066.0600 15690369.6900 16415409.6800 17048066.4500 17054646.6100 10960569.0000 11314827.1800 12607274.2600 13440001.7300 12973619.2000 13852422.8900 fumarate 4C13 169391.1005 147195.0531 189451.2687 270825.9663 233542.8204 180457.9015 321679.4447 359100.1194 336713.0065 50704552.2300 50359151.7900 49724796.1600 18155045.0500 16645564.6000 20442376.0200 37543799.6600 38361167.6300 38055749.1100 79304.9356 80910.4074 77601.2888 29999.4856 36367.7615 39628.2989 597548.8008 621359.9619 593984.6486 372056.9432 333778.8337 363156.8017 211791.7996 369054.2470 394683.7180 245266.0725 143504.3671 237833.5396 2633835.3440 2657196.6280 2887035.8990 731816.2720 670970.6996 689104.3379 397416.0438 400878.9548 415771.2750 656253.7224 659475.7585 713663.1992 639103.7414 670123.5291 666021.1541 114928.5083 138912.6198 127288.5552 157587.6429 139719.0283 126705.6572 80814.5536 103991.2750 76804.1845 326593.5870 336172.1065 363546.2152 167721.5716 177124.5206 212935.6690 506642.9382 582761.6916 562408.6958 245362.4494 263333.5863 235746.4539 370497.8763 448347.9805 426228.4440 380250.8483 362647.0444 347968.1215 359931.4325 321437.8784 389114.1635 311418.0870 405718.7814 520521.0681 6548705.8770 8046379.8640 10096848.0100 3457803.2060 3820004.0290 4105414.5280 7564909.8260 7704225.1850 4105868.0450 2424285.1870 2403821.1140 2234645.7230 6234696.4530 6270156.9980 6952626.8650 36131541.4400 36184779.0300 38346379.5100 20303295.8900 24455151.0500 22355513.8400 22875108.8700 25659627.0000 25063010.4700 2370323.8380 2099728.3980 2168488.1670 1174256.2070 1106793.7800 977620.8615 2372009.9900 2603797.2990 2625461.5360 658931.4193 721716.3158 648047.8314 1921295.5230 1828485.1970 1710178.0420 13552014.2800 14671232.4600 14870794.1100 15331793.5000 10759403.9700 10624954.2400 12086481.0600 16631243.7800 16195236.5800 17320013.2000 fumarate C12 170660806.2000 168029128.1000 168528194.4000 83994053.0300 76058667.8900 75864041.7400 86289222.2100 104748274.2000 104677967.5000 158195762.7000 160595954.9000 157508333.1000 75520130.8600 65920496.2500 74425156.2900 82318218.5100 84429689.1700 83732570.4200 13815877.4500 20055819.7700 14530239.3200 12749877.1800 12356011.2300 15340066.4500 89288043.4100 89035830.5300 93254894.7700 83643314.8000 80211942.2500 81314370.6300 9721793.3010 28558245.4800 31025587.3500 15113742.9300 9890375.6590 13284951.9200 106761096.1000 93888078.3100 102727352.3000 115661183.3000 115442100.6000 129329604.0000 99868002.3200 99319209.1500 95704718.0600 172380748.2000 183403950.1000 193921811.3000 116074412.6000 111039054.8000 113892046.7000 146474580.7000 148042252.7000 166223237.9000 217046200.0000 206998145.5000 242490300.4000 141109318.9000 145561656.2000 138330915.4000 56941276.0800 66056463.7500 61032752.7700 28576568.4800 25671750.6200 32469412.3500 67472143.6300 72736399.2100 73843706.2100 64489729.9700 65197409.5500 67680724.3200 122724538.6000 149382226.2000 131726954.9000 148303621.5000 153509741.9000 153291427.4000 71706822.0500 81044395.5800 85446104.3600 71555100.7000 77418819.4900 93378356.5800 45171262.5100 57239282.9700 72329138.0200 31461911.1200 39111110.5000 42555927.0900 99688613.9300 104079585.1000 109136752.1000 87000707.4800 78867699.6100 77980506.0500 161311676.6000 160386002.0000 185616155.1000 134614867.0000 136494222.7000 143497260.9000 79140785.8100 96132912.8100 88951677.1100 72603252.3400 80196828.2100 77521249.3800 36055078.5700 34727123.4500 36003210.0700 25546245.3800 22454476.0800 22754379.4100 85956637.3000 87307439.1200 93928716.4300 111383438.5000 105309436.7000 102843669.8000 182277508.2000 174946551.2000 161778300.2000 135693021.4000 144290223.0000 150634416.7000 152513616.6000 77879601.5500 79573677.0500 87487720.5300 85818152.8600 84144685.3600 89015592.0200 hexose-phosphate 1C13 551948.6321 551403.0130 472208.4266 210732.5424 333358.3268 296086.8155 755538.0459 824453.7595 1039392.4070 8572490.3250 7911949.5490 8427203.4550 17197493.2700 15587802.6200 14353028.5800 26982244.1400 20724765.4500 22977042.4900 351909.7650 507370.3341 381410.4270 172306.4836 107606.4585 167282.3262 2159657.7210 2084768.1460 2269269.7710 440391.3867 480561.4785 482734.5648 2736498.0410 5878688.2840 4067288.1860 2309158.3170 1709826.5000 1642958.2830 36214796.3100 28775651.3500 34812110.0200 3943032.9130 2142174.0140 4488030.4900 276582.6785 372042.7065 271045.2135 208406.4047 648593.1264 222577.8327 601118.7864 628385.3663 620528.0402 3844115.2160 2844382.0760 3694852.7040 8018908.1290 6547405.2840 7035510.7280 5196702.7870 4472671.1060 5615655.0620 877840.0449 810952.7027 737966.8283 30269.3257 80600.5850 278715.0721 1426232.1850 1453223.4060 1387955.9670 383747.8520 370913.3997 390605.5565 363211.2788 246242.7264 529705.0771 482353.3855 497573.9366 320418.9618 407284.8957 547767.9417 149961.3000 493187.1018 616876.0997 548151.8741 7774359.7250 10315572.9800 12228799.9900 4676022.3840 7417722.1870 7496283.7500 30485678.4500 32287988.6100 27176233.1200 4143891.9820 3147236.6200 2568114.1310 13304471.1700 10211126.5400 10426411.0600 6056179.7360 10460791.3300 7187211.2240 22139976.7000 22580993.8100 17712805.3800 13930742.5100 19109639.2400 16453495.1400 4166256.5670 4036237.8630 2865050.2980 1994833.5480 1586627.6120 1788929.2820 17490490.6300 16937843.0700 17422959.8300 2267070.1070 2411213.2150 2305023.8170 4941322.8190 4976313.1270 4630090.1520 3851420.6970 3883257.6160 3746405.4290 3828321.0520 9512475.5860 9880123.3580 10408958.6600 11548471.1500 10578877.2600 10187201.2200 hexose-phosphate 2C13 2443427.2090 2832302.5780 2925533.1890 6007302.9760 4297341.9060 4771504.8500 5874361.0760 8929821.4000 6897300.0690 15077613.0800 15077613.0800 15077613.0800 4903870.7340 9127456.0290 10658618.4200 15077613.0800 15077613.0800 15077613.0800 16714577.9500 18121381.4500 19286715.6800 15077613.0800 15077613.0800 15077613.0800 3517054.8630 4101677.6770 4384509.5260 11341263.9800 15707728.3400 15804476.6700 15077613.0800 15077613.0800 15077613.0800 3114382.0680 3805957.3730 3732941.8300 10711608.6100 10885032.7200 11965057.4500 15077613.0800 15077613.0800 15077613.0800 2920315.0720 2562312.5240 2821849.5610 hexose-phosphate 3C13 858661.3939 927543.1892 689477.0814 874410.0635 961937.6478 751547.8681 538416.6145 538125.5076 679357.5706 290105.4951 290105.4951 290105.4951 134770.8811 220233.5997 256417.0103 325288.0200 98800.6567 221078.1057 613634.4298 972394.1583 838805.6882 4024477.4790 4183595.9630 4429720.0080 166804.7031 203957.8328 219926.2658 251530.9655 574001.5532 580732.8333 1010733.2850 1010733.2850 1010733.2850 19066.1811 14818.9368 21158.1153 197160.5121 199598.2472 171372.3783 588305.3972 213594.2994 588305.3972 992677.6147 766668.4483 707967.2084 21549.4663 23419.0228 24036.5677 588305.3972 588305.3972 588305.3972 290105.4951 290105.4951 290105.4951 2315826.7890 2388709.2590 2210958.1710 2786060.1120 2728172.3880 3487577.0440 223510.3668 187473.5435 207198.5981 617800.5024 646250.6182 896030.5406 597251.0534 469829.5927 230009.1100 1118694.0900 1372698.4230 1354004.0670 729738.4435 642237.5061 671919.0519 692265.8929 1101038.5170 993616.9880 1010733.2850 1010733.2850 1010733.2850 9470.4033 3239.3308 8179.5176 588305.3972 588305.3972 588305.3972 290105.4951 290105.4951 290105.4951 333985.9812 238301.3835 198788.0024 179195.2608 180174.8133 181843.7559 987996.8235 946262.6877 931244.7391 1348718.4230 1248710.8500 1297107.5200 166369.9723 175041.3982 148249.5308 588305.3972 588305.3972 588305.3972 123707.3189 136209.8297 181706.8580 133932.0122 512727.7980 537453.9363 567466.9145 342300.2181 350505.7853 280981.7030 hexose-phosphate 4C13 494030.7773 459877.7338 277431.5620 746255.4252 875194.3229 766495.8864 1138668.6980 1575814.1700 1363446.8690 3585.6008 3585.6008 3585.6008 109359.3005 109359.3005 109359.3005 34650.6113 34650.6113 34650.6113 159207.7173 301958.1095 232110.6186 2088079.3760 1998834.4840 2294457.3820 176068.2898 187274.9698 211760.2635 614227.8616 304559.2271 255495.5345 202488.6553 181902.9279 167620.4354 329170.2964 507895.4725 358786.7071 327544.1255 308219.2485 266395.3144 47332.8392 243.4496 1781.8605 3585.6008 3585.6008 3585.6008 914081.7593 777139.6101 848848.3510 1515137.7230 1583433.8150 1786804.2030 220299.2415 162063.3850 184305.3760 796273.5891 706183.9626 932130.3848 409660.5765 335477.9143 244882.9149 970221.5063 1283425.6630 1326875.9600 898998.7444 918657.4065 989565.6023 360970.3379 324076.0270 630391.6593 65856.9971 16711.2629 17850.3919 3585.6008 3585.6008 3585.6008 109359.3005 109359.3005 109359.3005 34650.6113 34650.6113 34650.6113 177963.7082 211889.4050 127978.0001 1012359.1050 923743.7761 1101344.1680 138344.4847 135400.9590 132269.1067 129985.8422 180343.2645 192300.2808 107286.1796 122980.0605 132924.7631 159124.3586 284306.5489 317131.5506 345190.7995 525942.0992 569777.8842 488328.8430 hexose-phosphate 5C13 7840495.0080 6117197.1940 3858854.5960 10474326.5800 9898550.6120 9550104.7740 14972256.7000 17406248.5100 16405254.4000 1946.3987 1946.3987 1946.3987 3919.2434 3919.2434 3919.2434 3058524.4730 4345560.1330 3772071.1840 1079048.4220 928228.9185 1229954.3310 22579152.3700 18866600.9400 23547762.4200 2601008.9750 2543553.1310 2702551.0920 46363.8310 151557.8921 103364.4113 1791915.4470 2440962.1000 1806621.3860 6595433.7250 9686107.5060 6981826.7890 3893214.0770 4419531.3030 3372244.7180 169447.3992 207785.8775 167608.4407 1946.3987 2224.2027 1946.3987 8371509.0660 9587367.2660 7553054.2470 656394.0343 1925147.0800 3510209.8090 22102579.5600 21911621.8800 20571360.8600 2744599.9030 2120673.2870 2455919.7870 10530010.7900 9663360.6400 12029786.2400 4176944.4970 4309506.9750 3978168.3350 10709568.7300 12408343.1300 14678577.4800 11307529.8700 11748317.8600 13762207.8100 3189.0346 67816.0091 88494.2557 173885.7710 109634.4118 168282.4189 137973.2372 1946.3987 1946.3987 1946.3987 3919.2434 3919.2434 3919.2434 2915888.1900 2723555.1490 2025336.5700 984794.8845 846600.0430 845527.7196 10070194.1500 10155687.2200 10241153.9900 1413171.8910 1547363.8810 1376533.7570 4222091.0740 4167142.8680 3894447.0960 2176729.0350 2253438.7850 2332058.5780 2324257.7750 4756258.2710 5341498.2980 5676491.6890 6816186.7790 6350031.0520 6454308.1890 hexose-phosphate 6C13 138222705.6000 107151033.6000 68509622.4600 155141461.6000 145400949.6000 143768665.7000 227653584.4000 260969815.2000 247608949.2000 3922.4680 3922.4680 3922.4680 489.8341 489.8341 489.8341 4841.6256 4841.6256 4841.6256 55256236.6400 79029079.7900 65554766.3800 23951963.3100 21035935.7300 26544151.8700 415615676.6000 340689520.0000 431596431.5000 43332804.2100 43577647.5700 44499085.3300 926.8634 926.8634 926.8634 31601325.7500 41451769.4100 31062489.5100 115161716.9000 172121759.5000 122766403.7000 67151750.9200 79145746.1100 61532361.4600 926.8634 926.8634 926.8634 3902.1526 6123.7212 3902.1526 663.1305 3922.4680 3922.4680 142903737.7000 158866975.2000 130633344.3000 15992432.5900 40237508.1400 71422397.1400 409969148.9000 409477611.4000 384643805.1000 47152832.7100 37449172.4800 40659560.7200 180893030.8000 161500336.7000 202271309.4000 72470927.9100 75561572.4900 69279112.1700 159848199.9000 185002388.6000 215901601.7000 171647645.2000 176634185.7000 209288687.4000 5828.3996 26433.8811 926.8634 926.8634 926.8634 3902.1526 3902.1526 3902.1526 3922.4680 3922.4680 3922.4680 489.8341 489.8341 489.8341 4841.6256 4841.6256 4841.6256 51862016.3300 47787159.0300 35281773.3200 21931156.9100 17774978.6200 19486779.9900 193598833.1000 189440705.1000 193854721.3000 23886956.7000 24261206.5500 25103753.2200 72267927.8700 73348963.1300 70253407.4400 41155843.7000 41716040.5900 41725697.8700 41535146.1800 72268345.0400 81025638.5200 86501300.4300 106201152.2000 100379946.2000 95808288.5600 hexose-phosphate C12 5809660.2060 6521223.6500 5585389.7980 4080550.9110 4138690.5350 3613369.1800 11039337.4900 12101879.7600 13329305.5600 128628436.0000 119492741.1000 128143339.6000 259997503.1000 234787365.3000 221380610.8000 400645130.0000 312406963.7000 337481380.4000 4914571.8440 7151352.3900 5560794.0980 3857465.0980 2920176.1730 3652124.3190 26333962.7800 27097049.9000 27034589.9300 6780713.6980 6678877.5610 7078814.2520 41302954.9300 89390501.5500 64429607.4600 36816420.9300 27437012.9500 27834763.3300 534624237.1000 426127056.1000 512490082.3000 60469925.8900 30994278.1300 67218682.0100 4370890.2210 5101355.7010 3680564.6570 5377387.0840 8763225.3760 5613289.2180 6966475.4710 7065218.2220 6758767.6330 55765923.4400 42029829.3200 55807576.7400 125495129.9000 103133920.7000 109482545.5000 78385439.0600 70184761.9600 86252596.1500 10740403.7700 10555312.4800 9973482.9670 2071836.6550 2440526.0540 5005743.5950 16061861.9600 17382445.9800 15856428.2200 6233704.1890 5532504.7300 6143414.7990 6667879.0630 5861735.4000 8014385.8210 6218700.5910 6114805.4970 5156510.1200 4731685.3800 5891075.7940 5167992.2200 6728740.9140 7471214.3100 6901911.4060 116592789.9000 155511264.6000 181416256.0000 74096836.5200 115880507.5000 115972870.6000 450479914.1000 484361884.8000 400175538.4000 62011793.3600 45406098.6300 37307232.0600 202212545.7000 155407370.4000 161673407.1000 94856908.9600 159351804.9000 109980178.5000 330325200.5000 343560667.0000 271380220.6000 210537779.3000 285528582.3000 247583229.8000 62411085.8900 58926594.9100 43834345.3600 33886840.8300 26600080.1100 29921110.0700 258255404.7000 254189364.1000 260801740.9000 33952863.4300 34875198.5500 35293483.4000 77651368.6800 78764544.0100 75244841.2500 55860822.0200 57401572.2500 57775335.9500 58115005.9000 145769258.4000 151214980.2000 155232668.0000 170964532.9000 161826007.2000 150784586.5000 malate 1C13 79849908.3500 78682819.1300 79807472.0600 47095536.2700 43732516.4300 44231437.5600 47019583.0500 57628127.0500 56986846.7000 71558482.5800 73310344.7800 69337176.2800 40782315.1400 37429816.9600 42223080.2200 42099976.8500 44076990.3500 44107766.2300 20437778.9500 27083676.2500 22340876.8200 9844732.0020 10276865.2200 13057273.7200 66277077.8000 67259129.2400 67497740.8800 33065242.5900 30900622.3100 31859280.6600 16533949.9800 31532876.9000 34476149.9800 12644511.3900 8076339.1660 11608768.3400 70780558.4900 63468888.4700 70845367.3100 43359460.4700 41445670.6400 45441255.2800 39510506.7600 40841088.2500 38629020.4200 84905859.3900 91912308.3800 96983730.2100 55788716.1100 54106655.8400 53223030.8100 54914238.9100 55164280.2500 58072295.1400 99674638.3600 95307384.6500 113190295.2000 63078628.1300 65977019.2800 62406069.4300 63534559.8800 67418857.1000 68284707.6700 24798122.4700 21803420.3100 28686521.1500 47062153.9800 51413414.9700 51941821.9400 25352325.6000 25126186.2300 26482785.4100 56875413.6300 70295435.9200 61870325.7500 71700836.0200 73938516.3100 75188783.5600 42697060.7800 46556446.1200 48729869.1300 39357933.1800 42320050.6000 51364525.7700 47819154.9100 60215171.6100 77328634.1300 25477715.2700 32610996.5600 35283162.3700 64976584.5500 68741063.5600 73095865.0400 31627221.2400 29627574.7600 27825295.0500 73301464.8900 73568719.1000 84672915.1300 59929635.3300 62601801.7100 65493717.1200 44804564.7600 51929360.1200 49273461.7200 38109463.9700 42272891.2100 41356691.9800 42937168.3300 40300123.7700 39795173.2200 22467301.2200 18575114.0300 18267140.9700 63930164.7200 62394424.7700 63797526.0900 40594253.0800 39450565.9200 38703551.9200 84977296.9000 81808106.5500 79240287.2000 65518152.9100 66374959.2900 68248881.2300 69805633.2700 44909810.5200 44704414.8800 48511915.6300 46179762.9500 45049390.1200 46774014.7300 malate 2C13 9395689.0860 9065662.8130 9314418.4680 9765322.1210 8786080.3310 9332903.7090 12587844.6700 14712447.7700 14430899.9600 4871793.8610 5187798.4640 4485261.7010 1562721.7800 1424157.2620 1516681.8750 2983726.4450 3231744.4940 2925882.6870 4579764.5990 5987313.1530 5000219.8270 2545479.7730 2530964.5320 3038010.8290 28673895.2500 30613373.2900 29561891.5300 11970578.1600 10870210.1300 11785602.3300 278995.5181 451577.6071 510158.9217 341614.4213 236700.8775 343357.1594 1215621.9900 1132544.5140 1255603.3690 497956.1838 496240.1516 576926.1455 12598844.1500 12865851.6400 12567713.9900 19508998.6700 19583064.3800 20851088.6500 14816067.8200 14583847.6900 15029586.7000 616028.0889 622017.8960 658098.1216 1404038.7460 1320377.1730 1412897.8110 938755.2563 991827.4114 901425.5005 22781227.4800 25027909.5100 25509039.7300 9396628.5520 8745283.8110 10682538.3900 23752763.4500 25871985.7700 25559751.0200 10305331.9900 9610278.8800 10600012.0400 16386161.6200 18515128.5000 17265369.4500 30528106.2600 31375814.5800 32255731.5100 17321215.3200 18328502.5600 19786126.9500 17749530.7800 18971016.8100 23095917.7000 1521031.8890 2137617.1280 2580738.5650 1047970.3270 1176943.7910 1327250.6530 1633690.3930 1806542.1760 1372021.6650 459615.3334 437265.3732 482589.7706 1307004.3710 1354367.9670 1426709.8750 5717588.6330 6309362.6780 6110899.8260 3800611.7300 4381185.4450 4058503.8810 4043146.7150 4358133.4060 4165431.0490 7242173.8020 6846305.6450 6481892.5870 3611960.7430 3332397.9940 3167332.0440 14788855.4500 14477440.3700 14252632.0100 6162934.2300 6095937.7980 5905661.1910 10130835.6100 9673548.3220 9586533.5960 10571497.8200 10810641.6200 10910771.4400 11551122.8200 7892888.1860 8083380.5380 8812185.4940 10207263.2600 9696335.4340 10211230.2000 malate 3C13 110407869.2000 105675038.9000 109759285.6000 138859927.6000 125580667.5000 130977427.6000 152866965.7000 177393903.0000 176266948.1000 44822496.4400 46315390.5700 41293284.7400 13033383.9200 11773504.6700 13019252.9800 26922556.6500 28561659.0600 27809875.9700 87025297.4300 112594845.5000 92858790.5300 61298922.6800 62591566.4100 74929010.3300 538472105.7000 598578290.5000 543443603.1000 205353809.7000 186269778.7000 210425678.1000 341775.2839 521270.4271 573339.9007 416029.6970 269750.6203 372765.3029 5270339.5710 5427672.7470 6180301.9090 674536.6684 701270.6862 800463.2080 203665962.5000 214767729.1000 210011226.0000 331577915.1000 321568029.5000 353555061.6000 287648765.6000 289671614.5000 303228458.5000 312350.9185 317910.1929 320724.0787 950157.9588 845893.8079 1060517.1630 254373.8934 192816.1902 247513.5412 198225379.3000 219045396.8000 216206665.2000 137839079.1000 126450526.2000 155867518.1000 369775799.2000 390656521.9000 393717800.6000 131444175.3000 129271694.9000 142193181.2000 217056378.4000 244819953.9000 222048053.3000 157150874.7000 155907256.8000 172946963.9000 140280366.0000 148148605.8000 162166872.9000 121073972.4000 129482199.7000 167454790.1000 7163897.7600 8978962.2710 11238951.0700 4191615.0060 4630907.2130 4854595.3880 10862114.7400 11491498.0600 6290406.7850 1953808.4390 1870759.2760 1774856.1640 5804689.7600 5452109.6000 6391440.9130 27236958.9500 28230259.5600 28125831.2900 14889598.9100 16716377.9800 15671111.8900 15580903.0500 16650078.3200 15862121.5700 72751328.7000 68157170.6900 67440092.3200 57211576.5600 51362254.7200 49495041.3800 242351608.1000 237019120.0000 243594298.7000 96756402.9800 92128919.4700 91780157.1100 145924453.5000 143498402.5000 138089470.7000 100066219.2000 103986160.0000 108360980.1000 108918448.0000 74185728.9600 73993198.8000 81013597.5300 85584768.3300 82649349.5000 86182573.0300 malate 4C13 1322312.5180 1263126.4670 1208471.9730 1477836.8920 1348249.8540 1296335.9070 1669426.9030 2027424.0800 1898180.8910 272787521.2000 277466880.6000 269981582.9000 100988258.5000 94040009.9500 109042730.0000 193024694.8000 199302529.5000 202502782.3000 883154.7718 1264708.4480 939730.0645 639470.8356 605470.1035 726459.9433 6128450.9600 6973033.9050 6268570.0250 2061966.7630 1804783.6040 2090405.3120 2179994.9230 3900591.3600 4084598.9130 2631213.3630 1441690.6620 2180671.2590 28259298.1300 28001814.0700 32957912.5900 4004795.1100 3926848.6960 4117761.8480 2224813.4410 2374062.8930 2319068.4470 4197936.2710 3918737.2330 4093370.4390 3996434.6510 3832336.9770 4096085.0730 810988.2204 882030.8705 826276.6632 1504782.7250 1450920.9750 1827277.4470 864530.6850 1011225.4710 854835.7871 3289263.4510 3545971.7070 3510606.4640 1832406.9270 1645574.9810 2067279.7070 5408874.0570 5734205.0410 5874657.8010 1364340.7010 1338998.7800 1569456.8290 2487444.6240 2853540.3160 2694109.5870 2555760.0600 2544570.5760 2646222.2930 1980456.6260 2068288.2060 2332621.6320 1927365.4710 2074801.3590 2634400.0030 63185094.5900 78948268.8400 99019165.3000 32210463.7700 36448953.1100 37876720.5800 80711991.3300 84809593.2200 43474525.3200 13217441.6900 12674493.2300 12291732.4800 36711247.1700 36691197.6000 42923214.2700 195396763.4000 196682698.2000 213771937.9000 111622722.8000 129252534.8000 121374508.3000 121060930.5000 135545314.0000 130184891.5000 21972565.7000 21013853.7600 21060889.5400 11322959.9400 9963279.4180 9747139.6690 27717510.7400 27350131.6100 28114935.7100 4023398.6750 3848779.7300 3970374.0920 11397437.5800 11178398.1500 10453323.2600 74595480.5300 78630816.5400 81191024.5100 84440517.5000 59392749.7000 58067743.6700 63079480.7800 87395217.2800 86055837.7300 89209471.1400 malate C12 1842597413.0000 1840224239.0000 1826208740.0000 1056588347.0000 979313149.0000 972659556.5000 1030856713.0000 1269655047.0000 1266665842.0000 1665228450.0000 1705322413.0000 1645276243.0000 932751946.5000 848658685.1000 971386198.0000 985773513.4000 1022926404.0000 1030202387.0000 430370579.1000 582796799.7000 475318688.3000 220470977.9000 216339692.5000 285009700.2000 1305583995.0000 1325096201.0000 1332791457.0000 725770744.9000 681607832.9000 690984387.2000 368453707.7000 717825164.9000 771862892.8000 270453545.9000 176713050.2000 252009425.7000 1510545959.0000 1362794930.0000 1510784846.0000 1010985253.0000 965913394.8000 1062458300.0000 817023704.5000 859294486.2000 815890534.0000 1872258160.0000 2015205730.0000 2151645413.0000 1217020541.0000 1192128502.0000 1187639691.0000 1287388262.0000 1282159874.0000 1342303877.0000 2341073596.0000 2260197139.0000 2640555311.0000 1488397352.0000 1549304510.0000 1480013542.0000 1356965527.0000 1467065885.0000 1484122323.0000 531414980.4000 465677988.2000 613666132.6000 963798613.0000 1049189960.0000 1053040827.0000 547833961.0000 543814525.6000 576896521.2000 1317573319.0000 1623931473.0000 1420449617.0000 1561376624.0000 1634472138.0000 1610364677.0000 935174983.1000 1030215804.0000 1071217008.0000 881150073.0000 943341406.3000 1132746558.0000 1049686308.0000 1331032953.0000 1705296496.0000 550514147.4000 706371330.1000 758405939.1000 1386885715.0000 1472779741.0000 1565288710.0000 747652895.4000 692486878.1000 654150887.0000 1737515772.0000 1748000208.0000 2007564649.0000 1414494132.0000 1463555094.0000 1515515318.0000 1018430722.0000 1185438299.0000 1123006448.0000 884931051.7000 979897621.0000 956857753.3000 938550213.8000 881047048.6000 863956959.8000 492764278.2000 411476662.9000 400047897.0000 1322355538.0000 1282401646.0000 1319328026.0000 893674177.8000 895811557.7000 896618392.5000 1962709320.0000 1907619976.0000 1824767223.0000 1490112334.0000 1535668083.0000 1576272888.0000 1592776393.0000 1001536163.0000 1009632281.0000 1100480267.0000 1043698738.0000 1022178897.0000 1069015588.0000 N-acetyl-glutamate 1C13 1303717.5490 1123189.9170 1066454.3350 1070725.8850 981299.8103 1061971.8330 2021003.5770 2353377.5370 2381136.8240 752316.0659 733627.4841 741304.4212 569843.8845 571434.3417 668600.6781 1098978.5090 1210330.3400 1226644.3860 413777.0837 470344.6569 392883.4165 173665.7469 156866.8323 187119.4960 876202.8374 1012784.9270 916336.8865 594524.5048 667860.9162 566766.4563 219687.3042 406421.4914 452947.0991 142371.3523 77790.7574 106649.1032 610655.4484 599490.7444 690939.0381 501046.7798 460147.6742 512103.6759 754711.6925 774392.8985 737449.5933 1356642.1760 1510592.2810 1546120.3470 1407898.2320 1349745.6630 1400269.1740 559973.2749 541487.6626 586835.8013 1023071.7240 1036096.6540 1022330.1380 765101.4223 758879.8973 701669.7284 835853.7171 937329.5368 840876.4057 407354.1279 323022.2386 396106.1892 554112.4631 660356.4620 569965.5562 488053.6007 452306.0498 490729.0811 868637.1263 1147990.7200 1112293.8360 953187.1810 1019112.6210 1062989.4450 957955.5647 1113859.5480 1332350.5790 1291367.7930 1416649.1100 1432969.2190 585034.9638 647678.3568 895372.6012 287475.4380 296405.5289 395975.9357 416498.8178 512693.1932 493033.2108 351216.6498 350513.0091 308871.2587 894292.3597 967483.9278 1033318.2400 921740.1265 918390.3325 923297.2478 728063.3887 962352.1865 952550.8230 1067407.6030 1105602.1610 1109178.3390 472600.0243 560731.1114 564287.5248 238509.4925 223199.2999 254190.6741 693425.3604 649654.0914 631681.6640 532872.5320 592280.5801 610123.3943 1219792.7500 1134103.9060 1099576.8410 858217.9542 942833.0286 959953.8376 997409.1805 840618.8605 876743.5566 987359.8633 1419556.2890 1420400.7670 1341474.9500 N-acetyl-glutamate 2C13 486497.6053 452369.4242 371274.6746 638248.0464 667602.0789 665945.8256 957064.1849 1110244.1540 1123145.5810 10244.8454 1449.2336 7309.5199 45290.0578 115781.1901 138143.4381 140671.1787 77813.7809 116614.9176 100643.8100 10974.7864 10974.7864 513.7595 133585.3542 174040.7175 197835.2107 117828.6929 103231.5172 96383.5244 35127.1954 51282.2267 67639.2296 10974.7864 10974.7864 10974.7864 11224.4646 2099.9969 12537.0215 8030.5595 186133.9669 157592.7232 184153.0764 342150.6191 275579.7341 303281.9133 498488.3454 443353.7633 447148.0313 14014.5549 8030.5595 7060.8014 9655.8563 5213.9377 3237.6109 2166268.0530 2408262.6320 2168344.9880 701709.5849 629604.5465 751958.4283 800068.1288 994717.1935 932204.9569 418677.7428 387179.1160 432774.0101 1421910.7810 1590823.7700 1662536.8130 5611690.8230 5452687.2700 6009459.6570 6175927.6970 6433168.5030 8651747.4060 7616208.1790 7677976.4540 8872809.5330 22110.3059 42335.4124 89919.0601 10974.7864 10974.7864 10974.7864 7329.1058 4757.1316 12124.5598 9351.1885 1810.7188 7151.0741 15893.6827 21454.7848 11677.4884 14053.4129 16140.0848 34514.8893 27592.3937 123406.7891 119063.0379 134641.2807 417839.1870 433625.2268 486691.1976 143037.2293 144376.0943 147044.6991 273299.0871 269854.5735 260666.2896 118374.2703 81278.9925 107717.9922 587745.6686 534627.5111 473655.1305 945334.7963 941142.2093 1051247.9690 1125732.1840 1765650.5550 1807620.3520 1857432.8210 2134347.0910 2278018.4340 2224287.8460 N-acetyl-glutamate 3C13 514673.8969 514673.8969 514673.8969 514673.8969 514673.8969 514673.8969 17009.3909 109033.8357 109033.8357 202061.9061 202061.9061 202061.9061 51166.3811 31427.8802 9724.3189 109033.8357 7892.1801 2046.2163 202061.9061 202061.9061 202061.9061 9903.5822 38202.1649 27081.3753 38202.1649 27192.5991 9837.2726 45023.5051 36822.2697 46256.6191 38202.1649 31019.3680 19144.7590 41921.9714 77006.6540 66938.2420 109033.8357 109033.8357 22679.3693 202061.9061 202061.9061 202061.9061 38202.1649 6126.2901 3305.0521 6499.6363 16531.3034 77006.6540 514673.8969 514673.8969 514673.8969 109033.8357 109033.8357 36116.5948 202061.9061 202061.9061 202061.9061 7483.8997 38202.1649 38202.1649 28379.5180 77006.6540 77006.6540 514673.8969 514673.8969 514673.8969 109033.8357 109033.8357 2427.3842 202061.9061 202061.9061 202061.9061 1219.3299 38202.1649 19971.3784 26420.5510 19056.5797 46445.9901 514673.8969 514673.8969 514673.8969 N-acetyl-glutamate 4C13 2383.6140 2383.6140 2383.6140 3824.6729 4279.9598 1144.5011 28830.3312 28830.3312 28830.3312 258495.5029 176962.7272 208317.3920 337538.4398 282981.5365 363157.9909 670199.2303 694275.6665 744467.4205 1229.5582 1229.5582 1229.5582 876.0615 876.0615 876.0615 4181.4713 382.8818 4181.4713 1484.7097 1484.7097 1484.7097 32804.6230 61961.8388 73677.0762 9686.0751 876.0615 876.0615 217553.3912 214556.4681 237251.2141 99613.8923 98222.8155 116547.0795 1484.7097 1484.7097 1484.7097 9348.1689 2383.6140 2383.6140 2383.6140 165690.3098 145716.8333 158572.6208 191037.6776 219171.2321 288288.1178 399833.6495 346176.2617 364965.1396 119547.7547 99494.1725 86538.9162 42527.7601 27532.6962 14984.5168 52214.2162 101846.9271 82120.5784 1484.7097 1484.7097 3722.6432 9086.4612 217158.6668 182489.5129 238874.9989 230492.5220 220675.6499 329845.9706 277445.6579 247245.3776 322099.2836 93698.1949 103945.1161 135634.6780 33696.5198 33586.8064 22498.6809 119143.9397 134978.7428 41399.0074 77564.4170 95953.5145 80879.5463 231467.1120 98820.3807 194369.1881 286882.3309 281726.8493 290404.2247 348880.2257 407347.7489 416296.2212 461872.0672 450844.9658 469327.7476 37747.8653 40422.3419 50495.3476 22440.8751 20894.7338 5788.8502 132669.8840 93177.2234 122641.2772 45084.8183 22825.0970 61277.7887 111756.9187 113281.2514 117927.5232 75756.8471 152354.6151 211283.2225 134152.0891 220166.5609 267802.8843 248694.3517 350313.5722 390695.7018 341655.1024 N-acetyl-glutamate 5C13 29932.6652 35026.1857 60929.7178 3731.6364 1090.2918 9026.0268 5381.0957 11444.1809 7465227.3190 6902673.5310 7550754.8920 8228975.7400 7865845.4160 8816616.1100 18140559.9800 19012813.8900 18668405.2700 18554.4519 6475.8990 6475.8990 74444.6352 18715.2618 74444.6352 217972.4518 217972.4518 778.2737 8621.8655 8621.8655 8621.8655 1348665.2670 2517768.2670 2890289.8180 532584.5253 220304.7727 378664.4979 5933062.4100 5930139.4780 6654928.1930 3249083.0470 2916651.9850 3115607.7610 8621.8655 8621.8655 8621.8655 8122.6778 22852.4671 13110.9896 92108.7318 23082.6662 4509143.4000 4315004.3510 4502822.3720 6256355.2130 6047935.1580 6521120.0870 9477708.6890 8857546.2380 8800542.7020 5335.7036 13115.7610 6475.8990 74444.6352 74444.6352 74444.6352 217972.4518 217972.4518 217972.4518 8621.8655 8621.8655 8621.8655 9109.4441 9044.4342 51715.5938 13121.8194 3731.6364 1073.3973 1822.7646 11203.1258 22498.7556 13179.7850 3419632.1420 3855076.7660 4853310.3440 1464730.1210 1632824.9740 1903586.7540 3068149.1320 3274386.6770 1464441.1090 2482253.3790 2301492.5530 2336586.0870 5587815.5210 5348195.0170 5587679.4130 7860483.7800 7491176.4780 7878546.0540 9035049.7240 10531687.1900 9941766.5000 11721733.8900 12194147.3100 12503161.1300 1351887.6810 1618836.6590 1521100.4060 511723.6909 425857.3450 403500.0705 2122162.5640 2001633.7070 1929602.2150 1722136.2890 1758000.4100 1893375.4660 2969251.8900 2747782.9680 2781397.1550 3397587.8730 3755413.3000 4112737.1730 3838063.5990 4878662.1080 4639477.6090 5085116.6820 7968124.8500 7873241.3400 7355072.3630 N-acetyl-glutamate C12 16054716.6200 14427955.3000 13357788.2400 15372805.7000 15475223.0700 15249213.3000 28003747.7300 32450668.0100 32368443.6400 9909711.5060 9859927.4810 10338372.0100 9176653.7150 9277130.7200 9692608.7370 15191071.5600 16580162.0400 15858691.1900 5223204.4540 6632740.9300 5604451.2550 1976759.3970 2055855.4890 2665562.8900 11580478.6200 12985644.6900 12111010.9800 8723955.9310 8343890.8570 7740147.6560 2754418.6220 5196539.4870 5927225.8190 1805014.3720 1065303.1560 1548847.6790 8786863.0890 8115655.6550 8721825.9610 6283159.3010 5970345.4590 6417113.0440 9934972.0610 10244806.1900 9888140.7790 19259542.3700 19685979.6100 20709327.4700 18528172.5100 17271384.5700 18684891.9000 7639697.2340 7444615.5080 7353558.3420 13579663.8700 13369077.9900 14167056.3600 10738782.3300 10436694.1700 9781782.0480 11081205.1800 12538728.5200 11666407.3400 4495706.9580 4250983.2940 5192667.2520 6703786.6570 8325110.5440 6950345.6580 6130854.7780 5690522.8140 6137403.9710 12982071.3600 14548549.4300 14060886.0500 12215206.5700 12943954.8800 12874931.9600 13164277.3000 13908125.0500 17649568.3700 15739479.2500 16710745.7300 18112927.0700 7838515.6310 8984369.7130 11661660.7000 3731570.5910 4274399.6860 5116151.1270 6210122.2190 6753865.1240 6635591.1770 4816063.5770 4803501.8060 4491425.1710 12609196.0500 12468968.4800 13268326.2200 12435621.1400 11801552.7400 12366878.3500 11962477.5600 14046142.9000 12938114.1000 14066167.3900 15123667.0600 14644806.6800 6744077.5630 7293956.0540 7305120.0860 3390048.7960 2953463.6640 3098706.1420 9155282.4470 8633508.5370 8122113.0950 7534067.9590 7573309.6870 8006550.9140 15786378.7600 14646817.7000 14726932.4600 11423186.0900 12679969.3200 13644832.6500 13860507.7000 12891614.2500 12917349.9900 13847705.0400 19027003.0000 19183670.3300 18307818.4500 succinate/Methylmalonic acid 1C13 23568810.2000 22141939.1100 22289181.6400 7381411.3160 7294064.5610 5565558.7200 10204564.2400 12077916.8900 11914882.8000 8904466.6550 8727082.4970 8450620.6900 4302610.0420 3759146.3840 5838864.5950 5930189.3820 6529138.9750 6499139.6900 1698058.7520 5369155.5780 2058037.2200 2564356.7540 1987387.0780 2827912.8060 11554267.5100 9788280.6180 11305924.5400 11532280.9300 12142729.6800 10498188.5200 1168224.2470 12492884.8600 10381404.3300 5865707.1770 3224855.1620 4606674.6560 25377980.6100 24611403.1700 25669806.8500 16963887.7900 16623665.8300 19451968.8500 14334709.0500 16867426.0400 15501605.2400 33762848.9900 36891818.9700 38660982.0800 24430948.7200 22943944.5400 24402390.6600 25786986.6800 25566232.1300 27607265.9800 46064342.4600 42965699.6300 48963792.7700 27236848.5200 26932497.4000 27420887.9800 5703594.8410 3755150.9070 7890377.2060 1206088.8760 1559672.2300 1569297.3990 4781513.4480 6612314.6110 5979077.5500 3208235.6700 2959747.1280 3222013.3960 7987658.8160 9709747.8560 10289876.2700 13364984.0700 13395909.1400 12484564.7700 4648567.3900 6043677.4520 6649922.8160 8215153.9070 8592896.9500 9676265.3840 11149111.2900 1920193.1330 4013728.8830 1116043.1240 1448982.6360 2345986.6040 5783824.2910 6940842.3090 6866480.8540 1767866.7870 1754342.5490 1688609.6460 5407842.7710 5465946.1300 5858283.3600 5754922.0110 5635046.4250 5453691.2280 2201772.9100 3090421.0690 2372397.2860 4393167.4840 4466125.1600 5009152.7290 5855712.3900 4353022.1940 1296287.5120 2788815.5580 2424468.8310 2187523.3590 13823518.4800 12969149.2700 12499817.4100 14131198.5400 15102544.4100 15459139.9600 26030796.8800 26741471.5600 23174487.3400 15369011.3500 17084247.6000 17223796.3800 17403840.0900 4040206.5120 4633222.2580 6975170.4340 7340554.2900 7310436.4320 7541387.9070 succinate/Methylmalonic acid 2C13 3793840.5890 3512633.4520 3709411.6250 1367598.0830 1372120.2480 1142951.4110 1734093.0060 2231132.5780 2167382.4220 1382511.8340 1351954.6070 1292918.6250 525347.2821 513990.9135 681605.3284 1282284.5220 1461751.8560 1312250.9220 1738433.4880 2189795.8220 1823825.6180 1150944.0780 1060115.1500 1135914.4820 5252132.8100 4992782.6600 5541138.1960 3455885.2890 3580277.9440 3171497.9070 177440.4153 498463.6108 438724.7068 245640.6006 118474.1615 162073.8931 1349172.8650 1355376.4190 1666704.1090 311371.0587 322665.4301 345796.6111 4575660.5790 5374652.6040 5285257.8870 10615278.1900 11038806.5600 11829513.5000 7614907.6680 7178218.5050 7741011.2370 671263.1930 652195.6738 746268.4618 1374573.3210 1178374.9510 1423334.8580 690629.1636 653991.9248 672494.3590 12964368.3200 14126867.2100 14784696.3500 2057130.6260 2295753.2500 2067654.7580 4644113.8510 5494369.2970 4965585.4810 1345775.2860 1199723.9430 1257767.2760 4606117.0620 5737155.7280 6162754.3760 19345306.9800 19748043.0100 18090740.0800 6759187.2500 8557114.7070 9354645.4180 11052116.6800 11720278.4600 12804190.6500 930533.4007 1208798.1530 1665115.7790 480508.2416 519311.6810 592158.0766 815593.2022 896127.4343 616755.6241 117089.0035 128128.0918 106258.2834 418602.4165 431468.8776 406552.4927 4162221.3570 4332547.3620 3992291.7280 1985145.8270 2592231.5240 2046187.6730 3534212.9640 3801263.1730 3913518.3220 4011964.5320 3641374.3990 3497092.1240 996310.8242 961695.5245 1009452.7940 3018624.0860 2838599.0630 2808209.6320 1814080.6700 1901578.6290 1991269.0220 5060582.8970 4804641.1190 4411887.9580 5409580.3840 5671029.6830 5630612.2210 5818906.8380 2416069.2180 2695418.1820 3663407.5510 4413140.6070 4624468.8340 4573622.4930 succinate/Methylmalonic acid 3C13 1672504.8920 1586601.1000 1607976.5970 1339597.1440 1258272.4780 1068336.2770 1927670.1630 2087559.7750 2001772.2010 21170182.0100 20536126.8000 20163728.6000 8459943.2730 8163796.1380 10917665.6400 14954469.9400 16301164.8300 16237841.9800 43526020.9600 51579018.4700 41286971.1800 28285625.2300 26620174.8700 28482108.0900 113991890.6000 110420014.7000 114773952.3000 78299514.4200 81033622.0700 72450783.2700 945183.0551 1621395.9400 1710410.2970 718661.8261 318203.4797 527568.6579 5519831.4410 6027747.7330 6645165.6370 1893233.2040 1923295.9480 2011471.3590 97773984.2900 113606570.5000 111280709.5000 205299134.3000 214249924.9000 229374268.6000 185259893.1000 180516702.9000 195511305.2000 345781.0654 423610.1289 431506.9908 734539.5375 686153.7777 795606.3631 643400.9051 757225.6309 660304.8604 2909550.6520 3502536.3950 3496827.1440 803820.1382 961637.4308 845149.1748 1952517.1160 2169315.3270 2121552.3250 622180.3236 554136.2068 562341.3799 1369860.3640 1395653.8910 1569562.1060 2825321.4980 2864800.2940 2923272.8930 1203557.7780 1412758.7740 1753740.8700 2638176.1970 2713537.0380 3072583.5430 3594001.2630 4271922.0910 5499709.3610 1424433.7310 1407004.6420 1551312.6570 4847378.7110 5220752.7450 2643471.6510 2293973.2120 2401109.1050 2306572.7570 6346409.8260 6246264.0480 6918064.1530 11085195.9900 11106640.3500 11216857.5400 5537564.2140 6937651.2790 5760610.8790 8428382.5320 9165445.8950 9902053.2100 14686672.8400 13215262.4100 13250399.1200 7535673.2590 7836521.1600 7744578.4280 30300810.2700 28239646.4200 27999026.8600 33244915.5300 34859120.7100 36007650.9800 62348396.0800 63389344.5000 56945726.1800 37268633.2400 39515135.1200 39931370.0100 41020655.5900 4564024.0950 5004965.6540 6647670.4880 7694738.8910 8113099.7090 8027035.8200 succinate/Methylmalonic acid 4C13 403455.1836 377198.5138 434840.8729 104935.5815 165316.7055 173849.7132 140638.3856 191372.1232 166781.1627 681910683.0000 666767608.3000 649295227.3000 278352986.2000 263727624.2000 358177895.8000 486840411.3000 529167315.3000 527639143.5000 800691.8525 1302944.6160 714985.6680 465536.0515 415634.6461 450091.9288 2005260.7660 2085963.0610 2173293.3410 1332871.4200 1325612.2900 1138934.2190 36550893.3800 64405529.7700 65435570.4100 25719391.5100 13837027.6500 20478602.3200 164543192.8000 175539180.5000 195812715.4000 59770761.8900 58907017.2400 66199526.9000 2759111.7860 3177161.1080 3021516.9370 5836672.7340 6101632.5830 6575184.1770 5372785.3070 4855742.6500 5317787.7940 10438648.5000 11996188.6100 12095713.4500 17413541.3200 16294244.7000 18856673.8700 22474067.5200 25980578.0600 21858325.2900 3465506.0850 3812651.1060 3866807.9590 1048125.1580 1104502.3660 945438.5019 2601635.6010 3105661.8780 2778575.6660 544864.7730 474827.5895 523693.1017 1223975.2900 1350254.8230 1452033.6980 2444570.4920 2107652.3290 2244255.7260 1449329.9170 1555192.4160 1668436.7600 1852253.8430 1801305.0000 2243992.6150 136203385.1000 155838516.9000 206807497.7000 51960144.8300 53622674.2600 59958419.5300 153029895.7000 162521454.3000 87598593.7900 75165620.3700 77622582.6200 73700335.5700 201948230.1000 202551858.5000 217507787.5000 356618785.5000 359889423.7000 350738031.5000 180868436.0000 222373705.4000 188776414.1000 268688695.8000 291881125.8000 315774969.4000 60661247.2100 55659019.6800 55131281.8900 17967092.4600 18357353.3700 17979363.7200 93725891.4700 87163278.3300 87127203.2500 25929705.7300 27396627.5200 28044649.5100 56614356.9700 57280461.2000 50745168.3400 164799246.2000 176972316.6000 178143931.6000 182902714.7000 135192814.6000 143439901.3000 191951309.6000 216497771.7000 226015800.3000 228157382.6000 succinate/Methylmalonic acid C12 484764655.1000 452424183.9000 460819487.5000 151885235.9000 147635595.2000 112956448.3000 206719451.5000 244765007.3000 240583594.3000 184599366.0000 183620601.5000 178142261.1000 89742819.4200 81809923.0500 123065447.0000 126428876.8000 137227346.4000 134631108.9000 29201352.5200 107755704.3000 35260621.1800 55700056.1000 40627638.0500 63382307.6600 242944276.2000 213695288.4000 238452924.7000 244702150.1000 252406245.0000 217962603.4000 17893672.2800 258026282.1000 208569277.1000 124451138.8000 70995953.9100 96460837.2200 540991837.1000 523103227.1000 546827714.3000 351896668.5000 345424147.0000 407924334.3000 295071133.7000 344428960.0000 318727864.2000 690515107.2000 744468481.8000 777926288.4000 494282031.4000 468494061.3000 507685522.2000 530204114.3000 523883160.4000 563929638.3000 937784330.8000 866411063.4000 990134397.6000 553024753.8000 544640829.3000 551746392.1000 119090514.5000 61135573.1600 156656491.9000 25260584.0400 36812326.4900 37022402.4500 104960271.4000 143765522.0000 126294362.8000 68930404.6600 62222265.9100 69676169.7200 162369008.8000 202032281.5000 211724486.3000 271715884.6000 276186994.3000 255233992.0000 94106828.6500 124091376.7000 135122569.9000 166194113.8000 172147797.1000 193012300.4000 246178536.1000 37827131.1400 81632543.7400 25721353.8600 32818852.5400 51321413.7100 126896582.1000 151848769.4000 150473373.0000 38461863.8200 38539819.9700 35492164.9200 112592226.5000 113811757.5000 121643662.8000 119356494.0000 112789142.3000 111874182.6000 46219399.4800 66244768.0300 48021431.1700 89596116.6100 95927176.2200 103025675.2000 117826332.9000 88279641.3300 17609852.1500 61090233.2800 51655168.1200 50469830.5900 294494983.9000 271957312.6000 270665882.0000 296341704.2000 313805771.8000 318550000.6000 530179548.2000 536951050.7000 477778957.8000 321262628.7000 349473798.6000 350563893.8000 364037363.8000 82047802.6900 96699162.5700 144802893.9000 152797641.2000 155383645.2000 159179905.0000 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name pubchem_id inchi_key kegg_id other_id other_id_type ri ri_type moverz_quant acetyl-CoA 1C13 809.125061 acetyl-CoA 2C13 810.129089 acetyl-CoA C12 808.122314 a-ketoglutarate 1C13 146.018158 a-ketoglutarate 2C13 147.021149 a-ketoglutarate 3C13 148.024902 a-ketoglutarate 4C13 149.028183 a-ketoglutarate 5C13 150.03154 a-ketoglutarate C12 145.014832 citrate/isocitrate 1C13 192.023911 citrate/isocitrate 2C13 193.0271 citrate/isocitrate 3C13 194.030502 citrate/isocitrate 4C13 195.033798 citrate/isocitrate 5C13 196.037247 citrate/isocitrate 6C13 197.040833 citrate/isocitrate C12 191.020615 fumarate 1C13 116.007568 fumarate 2C13 117.01091 fumarate 3C13 118.014328 fumarate 4C13 119.017593 fumarate C12 115.004196 hexose-phosphate 1C13 260.026764 hexose-phosphate 2C13 261.029266 hexose-phosphate 3C13 262.033051 hexose-phosphate 4C13 263.036102 hexose-phosphate 5C13 264.040253 hexose-phosphate 6C13 265.04364 hexose-phosphate C12 259.023071 malate 1C13 134.018158 malate 2C13 135.021423 malate 3C13 136.024765 malate 4C13 137.028152 malate C12 133.014816 N-acetyl-glutamate 1C13 189.060471 N-acetyl-glutamate 2C13 190.063202 N-acetyl-glutamate 3C13 191.066223 N-acetyl-glutamate 4C13 192.07019 N-acetyl-glutamate 5C13 193.073608 N-acetyl-glutamate C12 188.057388 succinate/Methylmalonic acid 1C13 118.02327 succinate/Methylmalonic acid 2C13 119.026375 succinate/Methylmalonic acid 3C13 120.029907 succinate/Methylmalonic acid 4C13 121.032623 succinate/Methylmalonic acid C12 117.019928 METABOLITES_END #END