#METABOLOMICS WORKBENCH jsto1886_20241029_101113 DATATRACK_ID:5323 STUDY_ID:ST003588 ANALYSIS_ID:AN005892 PROJECT_ID:PR002218
VERSION             	1
CREATED_ON             	November 24, 2024, 8:20 pm
#PROJECT
PR:PROJECT_TITLE                 	Mitochondria complex III is essential for IL-10 secretion in macrophages
PR:PROJECT_TITLE                 	independent of respiration
PR:PROJECT_SUMMARY               	Mitochondrial electron transport chain (ETC) function is linked to macrophage
PR:PROJECT_SUMMARY               	function. However, mechanisms underlying mitochondrial ETC control of macrophage
PR:PROJECT_SUMMARY               	immune responses are not fully understood. We used genetic tools to examine the
PR:PROJECT_SUMMARY               	necessity of mitochondrial electron transport chain (ETC)-dependent respiration
PR:PROJECT_SUMMARY               	and the production of reactive oxygen species (mtROS) in macrophage immune
PR:PROJECT_SUMMARY               	responses. Here we report that mitochondrial ETC complex III (CIII)-deficient
PR:PROJECT_SUMMARY               	mouse macrophages, which have impaired macrophage respiration and mtROS
PR:PROJECT_SUMMARY               	production, exhibit increased susceptibility to influenza A virus and
PR:PROJECT_SUMMARY               	LPS-induced endotoxic shock. Mitochondrial CIII-deficient bone marrow-derived
PR:PROJECT_SUMMARY               	macrophages (BMDMs) produced IL-10 but exhibit dampened release following TLR3
PR:PROJECT_SUMMARY               	or TLR4 stimulation in vitro. Surprisingly, restoring mitochondrial respiration
PR:PROJECT_SUMMARY               	without generating mtROS in mitochondrial CIII-deficient macrophages with Ciona
PR:PROJECT_SUMMARY               	intestinalis alternative oxidase (AOX) is not sufficient to reverse the
PR:PROJECT_SUMMARY               	increased vulnerability to LPS-induced endotoxic shock or rescue IL-10 release
PR:PROJECT_SUMMARY               	in vitro. However, activation of PKA, an mtROS-responsive pathway2, was
PR:PROJECT_SUMMARY               	sufficient to rescue BMDM IL-10 release following LPS stimulation. Additionally,
PR:PROJECT_SUMMARY               	mitochondrial CIII impairment in macrophages does not affect canonical responses
PR:PROJECT_SUMMARY               	to interleukin-4 (IL-4) stimulation. Thus, our results highlight necessity of
PR:PROJECT_SUMMARY               	mitochondrial ROS but not respiration in release of IL-10.
PR:INSTITUTE                     	Northwestern University, Feinberg School of Medicine
PR:DEPARTMENT                    	Pulmonary
PR:LABORATORY                    	Chandel
PR:LAST_NAME                     	Stoolman
PR:FIRST_NAME                    	Joshua
PR:ADDRESS                       	303 E Superior Street
PR:EMAIL                         	joshua.stoolman@northwestern.edu
PR:PHONE                         	7343559440
#STUDY
ST:STUDY_TITLE                   	Mitochondria complex III is essential for IL-10 secretion in macrophages
ST:STUDY_TITLE                   	independent of respiration
ST:STUDY_SUMMARY                 	Mitochondrial electron transport chain (ETC) function is linked to macrophage
ST:STUDY_SUMMARY                 	function, however, mechanisms underlying mitochondrial ETC control of macrophage
ST:STUDY_SUMMARY                 	immune responses are not fully understood. We used genetic tools to examine the
ST:STUDY_SUMMARY                 	necessity of mitochondrial electron transport chain (ETC)-dependent respiration
ST:STUDY_SUMMARY                 	and the production of reactive oxygen species (mtROS) in macrophage immune
ST:STUDY_SUMMARY                 	responses. Here we report that mitochondrial ETC complex III (CIII)-deficient
ST:STUDY_SUMMARY                 	mouse macrophages, which have impaired macrophage respiration and mtROS
ST:STUDY_SUMMARY                 	production, exhibit increased susceptibility to influenza A virus and
ST:STUDY_SUMMARY                 	LPS-induced endotoxic shock. Mitochondrial CIII-deficient bone marrow-derived
ST:STUDY_SUMMARY                 	macrophages (BMDMs) produced IL-10 but exhibit dampened release following TLR3
ST:STUDY_SUMMARY                 	or TLR4 stimulation in vitro. Surprisingly, restoring mitochondrial respiration
ST:STUDY_SUMMARY                 	without generating mtROS in mitochondrial CIII-deficient macrophages with Ciona
ST:STUDY_SUMMARY                 	intestinalis alternative oxidase (AOX) is not sufficient to reverse the
ST:STUDY_SUMMARY                 	increased vulnerability to LPS-induced endotoxic shock or rescue IL-10 release
ST:STUDY_SUMMARY                 	in vitro. However, activation of PKA, a mtROS-responsive pathway, was sufficient
ST:STUDY_SUMMARY                 	to rescue BMDM IL-10 release following lipopolysaccharide (LPS) stimulation.
ST:STUDY_SUMMARY                 	Additionally, mitochondrial CIII impairment in macrophages does not affect
ST:STUDY_SUMMARY                 	canonical responses to interleukin-4 (IL-4) stimulation. Thus, our results
ST:STUDY_SUMMARY                 	highlight the necessity of mitochondrial ROS but not respiration in the release
ST:STUDY_SUMMARY                 	of IL-10.
ST:INSTITUTE                     	Northwestern University, Feinberg School of Medicine
ST:LAST_NAME                     	Stoolman
ST:FIRST_NAME                    	Joshua
ST:ADDRESS                       	303 E Superior Street
ST:EMAIL                         	joshua.stoolman@northwestern.edu
ST:PHONE                         	7343559440
ST:NUM_GROUPS                    	15
ST:TOTAL_SUBJECTS                	11
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	QHL1325	Cha-Jos-20231019-01	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-01
SUBJECT_SAMPLE_FACTORS           	LAQ1052	Cha-Jos-20231019-02	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-02
SUBJECT_SAMPLE_FACTORS           	LAQ1059	Cha-Jos-20231019-03	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-03
SUBJECT_SAMPLE_FACTORS           	LAQ1060	Cha-Jos-20231019-04	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-04
SUBJECT_SAMPLE_FACTORS           	LAQ1073	Cha-Jos-20231019-05	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-05
SUBJECT_SAMPLE_FACTORS           	LAQ1074	Cha-Jos-20231019-06	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-06
SUBJECT_SAMPLE_FACTORS           	QHL1325	Cha-Jos-20231019-07	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-07
SUBJECT_SAMPLE_FACTORS           	LAQ1052	Cha-Jos-20231019-08	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-08
SUBJECT_SAMPLE_FACTORS           	LAQ1059	Cha-Jos-20231019-09	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-09
SUBJECT_SAMPLE_FACTORS           	LAQ1060	Cha-Jos-20231019-10	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-10
SUBJECT_SAMPLE_FACTORS           	LAQ1073	Cha-Jos-20231019-11	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-11
SUBJECT_SAMPLE_FACTORS           	LAQ1074	Cha-Jos-20231019-12	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-12
SUBJECT_SAMPLE_FACTORS           	QHL1325	Cha-Jos-20231019-13	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-13
SUBJECT_SAMPLE_FACTORS           	LAQ1052	Cha-Jos-20231019-14	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-14
SUBJECT_SAMPLE_FACTORS           	LAQ1059	Cha-Jos-20231019-15	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-15
SUBJECT_SAMPLE_FACTORS           	LAQ1060	Cha-Jos-20231019-16	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-16
SUBJECT_SAMPLE_FACTORS           	LAQ1073	Cha-Jos-20231019-17	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-17
SUBJECT_SAMPLE_FACTORS           	LAQ1074	Cha-Jos-20231019-18	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-18
SUBJECT_SAMPLE_FACTORS           	QHL1325	Cha-Jos-20231019-19	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-19
SUBJECT_SAMPLE_FACTORS           	LAQ1052	Cha-Jos-20231019-20	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-20
SUBJECT_SAMPLE_FACTORS           	LAQ1059	Cha-Jos-20231019-21	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-21
SUBJECT_SAMPLE_FACTORS           	LAQ1060	Cha-Jos-20231019-22	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-22
SUBJECT_SAMPLE_FACTORS           	LAQ1073	Cha-Jos-20231019-23	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-23
SUBJECT_SAMPLE_FACTORS           	LAQ1074	Cha-Jos-20231019-24	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-24
SUBJECT_SAMPLE_FACTORS           	QHL1325	Cha-Jos-20231019-25	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-25
SUBJECT_SAMPLE_FACTORS           	LAQ1052	Cha-Jos-20231019-26	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-26
SUBJECT_SAMPLE_FACTORS           	LAQ1059	Cha-Jos-20231019-27	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-27
SUBJECT_SAMPLE_FACTORS           	LAQ1060	Cha-Jos-20231019-28	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-28
SUBJECT_SAMPLE_FACTORS           	LAQ1073	Cha-Jos-20231019-29	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-29
SUBJECT_SAMPLE_FACTORS           	LAQ1074	Cha-Jos-20231019-30	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-30
SUBJECT_SAMPLE_FACTORS           	LAQ1067	Cha-Jos-20231019-31	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-31
SUBJECT_SAMPLE_FACTORS           	LAQ1069	Cha-Jos-20231019-32	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-32
SUBJECT_SAMPLE_FACTORS           	LAQ1072	Cha-Jos-20231019-33	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-33
SUBJECT_SAMPLE_FACTORS           	LAQ1068	Cha-Jos-20231019-34	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-34
SUBJECT_SAMPLE_FACTORS           	LAQ1071	Cha-Jos-20231019-35	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-35
SUBJECT_SAMPLE_FACTORS           	LAQ1067	Cha-Jos-20231019-36	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-36
SUBJECT_SAMPLE_FACTORS           	LAQ1069	Cha-Jos-20231019-37	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-37
SUBJECT_SAMPLE_FACTORS           	LAQ1072	Cha-Jos-20231019-38	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-38
SUBJECT_SAMPLE_FACTORS           	LAQ1068	Cha-Jos-20231019-39	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-39
SUBJECT_SAMPLE_FACTORS           	LAQ1071	Cha-Jos-20231019-40	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-40
SUBJECT_SAMPLE_FACTORS           	LAQ1067	Cha-Jos-20231019-41	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-41
SUBJECT_SAMPLE_FACTORS           	LAQ1069	Cha-Jos-20231019-42	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-42
SUBJECT_SAMPLE_FACTORS           	LAQ1072	Cha-Jos-20231019-43	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-43
SUBJECT_SAMPLE_FACTORS           	LAQ1068	Cha-Jos-20231019-44	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-44
SUBJECT_SAMPLE_FACTORS           	LAQ1071	Cha-Jos-20231019-45	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-45
SUBJECT_SAMPLE_FACTORS           	LAQ1067	Cha-Jos-20231019-46	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-46
SUBJECT_SAMPLE_FACTORS           	LAQ1069	Cha-Jos-20231019-47	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-47
SUBJECT_SAMPLE_FACTORS           	LAQ1072	Cha-Jos-20231019-48	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-48
SUBJECT_SAMPLE_FACTORS           	LAQ1068	Cha-Jos-20231019-49	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-49
SUBJECT_SAMPLE_FACTORS           	LAQ1071	Cha-Jos-20231019-50	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	RAW_FILE_NAME(file name)=Cha-Jos-20231019-50
SUBJECT_SAMPLE_FACTORS           	LAQ1067	Cha-Jos-20231019-51	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-51
SUBJECT_SAMPLE_FACTORS           	LAQ1069	Cha-Jos-20231019-52	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-52
SUBJECT_SAMPLE_FACTORS           	LAQ1072	Cha-Jos-20231019-53	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-53
SUBJECT_SAMPLE_FACTORS           	LAQ1068	Cha-Jos-20231019-54	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-54
SUBJECT_SAMPLE_FACTORS           	LAQ1071	Cha-Jos-20231019-55	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	RAW_FILE_NAME(file name)=Cha-Jos-20231019-55
#COLLECTION
CO:COLLECTION_SUMMARY            	After treatment, cells were washed two times with ice-cold saline and scraped
CO:COLLECTION_SUMMARY            	into 1mL ice-cold methanol (80% methanol/20% H2O) and stored at -80C overnight.
CO:COLLECTION_SUMMARY            	Samples were lysed by 3x cycles of freeze thaw in liquid N2 followed by 37C
CO:COLLECTION_SUMMARY            	water bath. Samples were then spun at 16,000xg for 15min. Supernatant was
CO:COLLECTION_SUMMARY            	collected and analyzed as below.
CO:SAMPLE_TYPE                   	Bone derived Macrophages (BMDMs)
#TREATMENT
TR:TREATMENT_SUMMARY             	Glucose-free RPMI (Fisher) supplemented with 10% FBS and 11mM D-Glucose
TR:TREATMENT_SUMMARY             	(U-¹³C₆) (Cambridge Isotope Laboratories). BMDMs were plated 2e6 cells per
TR:TREATMENT_SUMMARY             	well in 12-well plates and washed with blank Glucose-free RPMI twice prior to
TR:TREATMENT_SUMMARY             	treatment plating in Glucose-free RPMI (Fisher) supplemented with 10% FBS and
TR:TREATMENT_SUMMARY             	11mM D-Glucose (U-¹³C₆) (Cambridge Isotope Laboratories). heavy-labeled and
TR:TREATMENT_SUMMARY             	treatment with either Lipopolysaccharide (LPS) (100ng/mL, Sigma) or vehicle
TR:TREATMENT_SUMMARY             	control for 0, 1 or 2 hours. After treatment, cells were washed two times with
TR:TREATMENT_SUMMARY             	ice-cold saline and scraped into 1mL ice-cold methanol (80% methanol/20% H2O)
TR:TREATMENT_SUMMARY             	and stored at -80C overnight. Samples were lysed by 3x cycles of freeze thaw in
TR:TREATMENT_SUMMARY             	liquid N2 followed by 37C water bath. Samples were then spun at 16,000xg for
TR:TREATMENT_SUMMARY             	15min. Supernatant was collected and analyzed as below.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	BMDMs were plated 2e6 cells per well in 12-well plates and washed with blank
SP:SAMPLEPREP_SUMMARY            	Glucose-free RPMI twice prior to plating in Glucose-free RPMI (Fisher)
SP:SAMPLEPREP_SUMMARY            	supplemented with 10% FBS and 11mM D-Glucose (U-¹³C₆) and subsequent
SP:SAMPLEPREP_SUMMARY            	treatment with Lipopolysaccharide LPS (100ng/mL, Sigma) or vehicle control for
SP:SAMPLEPREP_SUMMARY            	times indicated in text. After treatment, cells were washed two times with
SP:SAMPLEPREP_SUMMARY            	ice-cold saline and scraped into 1mL ice-cold methanol (80% methanol/20% H2O)
SP:SAMPLEPREP_SUMMARY            	and stored at -80C overnight. Samples were lysed by 3x cycles of freeze-thaw in
SP:SAMPLEPREP_SUMMARY            	liquid N2 followed by a 37C water bath. Samples were then spun at 16,000xg for
SP:SAMPLEPREP_SUMMARY            	15min and supernatants were collected for analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	15μl aliquot of the sample was used for high-resolution HPLC-tandem mass
CH:CHROMATOGRAPHY_SUMMARY        	spectrometry. High-resolution HPLC-tandem mass spectrometry was performed on a
CH:CHROMATOGRAPHY_SUMMARY        	Q-Exactive (ThermoFisher Scientific) in line with an electrospray source and an
CH:CHROMATOGRAPHY_SUMMARY        	UltiMate 3000 (ThermoFisher Scientific) series HPLC consisting of a binary pump,
CH:CHROMATOGRAPHY_SUMMARY        	degasser and autosampler outfitted with a XBridge Amide column (Waters; 4.6 mm
CH:CHROMATOGRAPHY_SUMMARY        	× 100 mm dimension and a 3.5 μm particle size). Mobile phase A contained water
CH:CHROMATOGRAPHY_SUMMARY        	and acetonitrile (95/5, v/v), 10 mM ammonium hydroxide and 10 mM ammonium
CH:CHROMATOGRAPHY_SUMMARY        	acetate (pH 9.0). Mobile phase B was 100% acetonitrile. The gradient was set to
CH:CHROMATOGRAPHY_SUMMARY        	0 min, 15% A; 2.5 min, 30% A; 7 min, 43% A; 16 min, 62% A; 16.1–18 min, 75% A;
CH:CHROMATOGRAPHY_SUMMARY        	18–25 min, 15% A, with a flow rate of 400 μl min–1. The capillary of the
CH:CHROMATOGRAPHY_SUMMARY        	electrospray ionization source was set to 275 °C, with sheath gas at 45
CH:CHROMATOGRAPHY_SUMMARY        	arbitrary units, auxiliary gas at 5 arbitrary units and the spray voltage at 4.0
CH:CHROMATOGRAPHY_SUMMARY        	kV. A mass/charge ratio scan ranging from 70 to 850 was used in
CH:CHROMATOGRAPHY_SUMMARY        	positive/negative polarity switching mode. MS1 data were collected at a
CH:CHROMATOGRAPHY_SUMMARY        	resolution The automatic gain control (AGC) target was set at 1 × 106, with a
CH:CHROMATOGRAPHY_SUMMARY        	maximum injection time of 200 ms. The top five precursor ions were fragmented
CH:CHROMATOGRAPHY_SUMMARY        	using the higher-energy collisional dissociation cell with normalized collision
CH:CHROMATOGRAPHY_SUMMARY        	energy of 30% in MS2 at a resolution of 17,500. Data were acquired with Xcalibur
CH:CHROMATOGRAPHY_SUMMARY        	software (v.4.1; ThermoFisher Scientific).
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000
CH:COLUMN_NAME                   	Waters XBridge Amide (100 x 4.6mm,3.5um)
CH:SOLVENT_A                     	95% water/5% acetonitrile; 10 mM ammonium hydroxide; 10 mM ammonium acetate (pH
CH:SOLVENT_A                     	9.0)
CH:SOLVENT_B                     	100% acetonitrile
CH:FLOW_GRADIENT                 	0 min, 15% A; 2.5 min, 30% A; 7 min, 43% A; 16 min, 62% A; 16.1–18 min, 75% A;
CH:FLOW_GRADIENT                 	18–25 min, 15% A
CH:FLOW_RATE                     	400 uL/min
CH:COLUMN_TEMPERATURE            	25
CH:INJECTION_TEMPERATURE         	275
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Plus Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	UNSPECIFIED
MS:MS_COMMENTS                   	A 15μl aliquot of the sample was used for high-resolution HPLC-tandem mass
MS:MS_COMMENTS                   	spectrometry. High-resolution HPLC-tandem mass spectrometry was performed on a
MS:MS_COMMENTS                   	Q-Exactive (ThermoFisher Scientific) in line with an electrospray source and an
MS:MS_COMMENTS                   	UltiMate 3000 (ThermoFisher Scientific) series HPLC consisting of a binary pump,
MS:MS_COMMENTS                   	degasser and autosampler outfitted with a Xbridge Amide column (Waters; 3 mm ×
MS:MS_COMMENTS                   	100 mm dimension and a 3.5 μm particle size). Mobile phase A contained water
MS:MS_COMMENTS                   	and acetonitrile (95/5, v/v), 10 mM ammonium hydroxide and 10 mM ammonium
MS:MS_COMMENTS                   	acetate (pH 9.0). Mobile phase B was 100% acetonitrile. The gradient was set to
MS:MS_COMMENTS                   	0 min, 15% A; 2.5 min, 30% A; 7 min, 43% A; 16 min, 62% A; 16.1–18 min, 75% A;
MS:MS_COMMENTS                   	18–25 min, 15% A, with a flow rate of 400 μl min–1. The capillary of the
MS:MS_COMMENTS                   	electrospray ionization source was set to 275 °C, with sheath gas at 45
MS:MS_COMMENTS                   	arbitrary units, auxiliary gas at 5 arbitrary units and the spray voltage at 4.0
MS:MS_COMMENTS                   	kV. A mass/charge ratio scan ranging from 70 to 850 was used in
MS:MS_COMMENTS                   	positive/negative polarity switching mode. MS1 data were collected at a
MS:MS_COMMENTS                   	resolution The automatic gain control (AGC) target was set at 1 × 106, with a
MS:MS_COMMENTS                   	maximum injection time of 200 ms. The top five precursor ions were fragmented
MS:MS_COMMENTS                   	using the higher-energy collisional dissociation cell with normalized collision
MS:MS_COMMENTS                   	energy of 30% in MS2 at a resolution of 17,500. Data were acquired with Xcalibur
MS:MS_COMMENTS                   	software (v.4.1; ThermoFisher Scientific).
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	Peak Area
MS_METABOLITE_DATA_START
Samples	Cha-Jos-20231019-01	Cha-Jos-20231019-02	Cha-Jos-20231019-03	Cha-Jos-20231019-04	Cha-Jos-20231019-05	Cha-Jos-20231019-06	Cha-Jos-20231019-07	Cha-Jos-20231019-08	Cha-Jos-20231019-09	Cha-Jos-20231019-10	Cha-Jos-20231019-11	Cha-Jos-20231019-12	Cha-Jos-20231019-13	Cha-Jos-20231019-14	Cha-Jos-20231019-15	Cha-Jos-20231019-16	Cha-Jos-20231019-17	Cha-Jos-20231019-18	Cha-Jos-20231019-19	Cha-Jos-20231019-20	Cha-Jos-20231019-21	Cha-Jos-20231019-22	Cha-Jos-20231019-23	Cha-Jos-20231019-24	Cha-Jos-20231019-25	Cha-Jos-20231019-26	Cha-Jos-20231019-27	Cha-Jos-20231019-28	Cha-Jos-20231019-29	Cha-Jos-20231019-30	Cha-Jos-20231019-31	Cha-Jos-20231019-32	Cha-Jos-20231019-33	Cha-Jos-20231019-34	Cha-Jos-20231019-35	Cha-Jos-20231019-36	Cha-Jos-20231019-37	Cha-Jos-20231019-38	Cha-Jos-20231019-39	Cha-Jos-20231019-40	Cha-Jos-20231019-41	Cha-Jos-20231019-42	Cha-Jos-20231019-43	Cha-Jos-20231019-44	Cha-Jos-20231019-45	Cha-Jos-20231019-46	Cha-Jos-20231019-47	Cha-Jos-20231019-48	Cha-Jos-20231019-49	Cha-Jos-20231019-50	Cha-Jos-20231019-51	Cha-Jos-20231019-52	Cha-Jos-20231019-53	Cha-Jos-20231019-54	Cha-Jos-20231019-55
Factors	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:0h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:1h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:Vehicle	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:KO + AOX | Time:2h | Treatment:LPS	Sample source:Bone marrow derived macrophages | Genotype:CTRL | Time:2h | Treatment:LPS
1,3-diphosphoglycerate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
1,3-diphosphoglycerate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	48199	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
1,3-diphosphoglycerate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
1,3-diphosphoglycerate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2,3-diphosphoglycerate	45209	16156	15570	0	13793	5687	0	0	8924	0	0	6575	0	6886	6845	0	8168	9050	0	12046	5454	0	0	7055	0	5877	5418	4495	9539	6345	12677	6111	6751	6122	19258	6120	6741	6193	6683	0	0	6609	0	5564	5586	0	0	0	0	10673	0	0	5786	0	5607
2,3-diphosphoglycerate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2,3-diphosphoglycerate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	4780	0	0	0	0	0	0	0
2,3-diphosphoglycerate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2/3-phosphoglycerate	486236	399912	324102	390343	882251	126780	19518	105404	84608	63140	139946	44490	228108	320049	30197	172499	340771	168031	217253	353615	124655	87392	344729	152112	392053	1325254	275915	381743	455162	378447	540228	501751	595465	710322	363391	390180	0	44206	175048	200997	563815	762326	343347	647743	522809	301711	301620	272601	423819	389871	324276	801573	153021	678047	444513
2/3-phosphoglycerate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10179	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2/3-phosphoglycerate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8226	6034	0	0	0	0	0	0	0	0	8156	0	0	0	0	0	7807	0	0	0	0	0	0	0	0	0	0
2/3-phosphoglycerate_13C3	0	0	0	0	0	0	0	14100	110898	41970	101997	197143	194933	294781	656160	508328	946312	604415	258735	324819	284626	157286	482409	312177	598232	368063	1195491	1033158	1241092	1005631	0	0	0	0	0	226649	117695	49452	246971	95190	654507	1065631	1004584	1286809	481706	461416	599801	586111	659730	479516	787380	1324413	985088	1167434	702170
2-HG	1088256	548797	2269960	315679	650556	2055227	1233073	738754	1778403	344686	492011	2660149	1468190	746009	2489456	892000	739447	2151254	963450	396545	1434900	448613	463299	1190976	804554	873106	1745088	477853	705053	1929142	75329	1188086	1822175	570669	213181	276744	1721426	1946224	791023	318485	703721	2058135	2515744	1105337	483466	278543	1177067	2040153	537314	80974	199357	2005452	2477066	1329821	293442
2-HG_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2-HG_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2-HG_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2-HG_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
2-HG_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
3-phospho-serine	21381	0	0	18173	67009	0	0	0	116183	14024	9539	24369	61193	164966	73464	50147	298405	163125	0	28700	26334	29193	95741	91489	219833	186736	199479	285005	304434	244937	0	44496	20594	33357	0	179823	0	0	0	0	344572	358464	281886	424516	91209	148445	177676	18869	225469	88489	304836	236080	0	475543	90706
3-phospho-serine_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
3-phospho-serine_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
3-phospho-serine_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	16936	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6-phospho-D-gluconate	82450	43806	26521	49887	281722	103395	27411	0	34845	183461	625339	63312	324240	579827	9656	394178	1169187	94765	55029	173079	0	51502	524722	29322	269359	170646	9090	293704	560753	43767	45486	0	0	119391	0	129175	197944	151619	559564	238068	386850	563576	565576	952681	536320	362683	205348	155374	518896	194459	535795	233740	35831	445785	270147
6-phospho-D-gluconate_13C1	0	0	0	6644	0	0	0	0	0	0	55881	0	15175	0	0	44522	145308	0	0	0	5656	0	49814	0	0	0	0	9688	26009	0	0	0	0	0	0	0	0	0	0	0	0	11634	11585	59544	0	12625	0	0	0	0	67515	0	0	13850	9340
6-phospho-D-gluconate_13C2	0	0	0	0	0	0	0	0	0	0	12447	0	0	0	0	0	117188	2829	0	7109	0	0	15612	0	0	0	0	0	8011	0	0	0	0	0	0	0	0	0	0	0	0	0	18843	31273	0	0	0	0	0	0	9145	0	0	8401	0
6-phospho-D-gluconate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6-phospho-D-gluconate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7419	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7028	0	0	0	6534	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6-phospho-D-gluconate_13C5	13697	8796	25448	31017	31846	16975	6893	0	54535	0	60777	59346	9966	41144	85564	5925	315488	107535	0	17897	21024	0	125942	64609	60323	0	64273	65374	125311	80187	0	44299	87105	74327	9593	149783	248251	228745	408325	72624	112926	358948	255462	494528	168767	72367	253883	282156	350516	103131	124550	481261	30697	538316	89355
6-phospho-D-gluconate_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	39825	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	23273	0	0	0	0	4725	0	0	0	0	0	0	0	0	0	0	0	0	0
acetoacetate / succinic semialdehyde	5068074	4565697	4971756	3772117	4746163	9292559	8008299	8231152	6678785	9023351	4061268	3965790	8008098	3507244	4200503	8243575	4493779	4279879	15367817	9314623	10906449	13983200	12928787	9451748	9076523	13318653	9838940	10745744	9303005	9542606	3655479	3883239	3441171	3697110	2479079	5088093	4180246	5547348	3280433	4454780	5843723	2763289	6209975	2610757	2143418	4655654	3264626	6906926	4719644	2959778	2849397	2805760	9505003	2260822	3203998
acetoacetate / succinic semialdehyde_13C1	294405	258344	289991	243117	357946	513814	397782	443346	189454	389764	280527	338853	459621	333015	268091	510175	314491	271212	916106	547497	548148	685634	629049	556224	486633	756442	594262	653712	497130	568080	281497	232925	277662	283533	205622	277000	192881	360523	233299	324373	439209	188553	292025	193349	183184	344959	254273	433032	249732	197109	217334	150204	524895	108806	233350
acetoacetate / succinic semialdehyde_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	4974	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2185	0	0	0	0	9306	0	0	0	0	0	0	0	7653	0	0
acetoacetate / succinic semialdehyde_13C3	519949	319233	342571	382301	444021	415349	514381	328598	273312	348713	429019	372487	468298	436478	327856	412942	441045	330065	462972	621163	411262	394415	508165	320765	431999	433513	372273	408250	400972	555520	296584	361077	248565	246268	270740	358503	574657	462797	538013	566832	545558	442857	640548	589740	1056910	378734	440764	599118	869797	924508	546186	686990	1197854	565529	724332
acetoacetate / succinic semialdehyde_13C4	81935	78055	129920	90915	67857	243530	231436	404219	415776	702447	376703	501878	776180	858874	822203	296245	826792	716912	1662822	1498742	1142734	1245389	1010816	1082048	944214	1196032	926349	1075315	971289	1074167	454759	386599	302356	267703	213964	237308	1398603	667488	1165910	1042799	782951	672441	962568	679811	792684	1107649	641030	868319	818923	835264	745332	613444	626450	544635	398124
acetyl-CoA +	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
acetyl-CoA_13C1 +	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
acetyl-CoA_13C2 +	0	0	0	0	0	0	88578	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
aconitic acid -	67197	82219	166939	142754	232846	81898	122480	124197	63676	134650	237601	0	63669	67249	197913	200274	64370	71026	777988	645047	696659	1171102	924857	1168768	1267332	1243322	1089369	1330652	1559824	935949	0	0	0	0	0	75452	93820	173582	158002	181703	53083	142639	428494	70251	150104	0	0	67943	0	0	0	60357	0	0	0
aconitic acid_13C1 -	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	13269	0	0	12953	21833	19131	0	0	71278	22871	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
aconitic acid_13C2 -	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
adenosine	426634	3304039	6958475	3370676	3690360	4678359	5375017	2303058	2484101	786873	4610019	2288189	3898103	2809193	2422534	1923354	2380155	3734214	1567352	1063983	2680241	891436	2688169	2791275	1075559	673105	5027884	1151954	1225084	1520118	2461785	2040261	1551845	1189152	2530057	1440701	131210476	72887323	87422219	57200007	6769614	32255619	18484592	26108672	13245419	14496253	37470057	24387992	53001756	12565159	12463296	5223729	51225134	24260442	8922599
adenosine_13C10	0	0	0	0	0	0	0	0	8666	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9180	0	0	0	0	0	6834	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8126
adenosine_13C5	0	0	0	0	0	0	0	0	0	8825	0	0	7586	0	5682	0	0	0	7848	0	0	6413	0	0	0	0	42851	9276	9485	26754	6753	9221	0	0	0	0	823934	324912	360606	109767	42990	451387	276528	268527	82140	144570	588575	264031	724228	12681	524822	124201	2024638	938564	259987
adenosine_13C6	0	0	0	0	0	0	0	0	8314	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	14146	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	15429	0	0
adenosine_13C7	562289545	384148159	735738684	976423958	668504599	0	412043306	612141971	1452013955	828564228	1040148513	974268124	0	584174403	420879398	1008409293	616491738	592260681	0	579168481	10452218	0	1952866487	1096453717	371156822	890953432	354615153	848772495	549728371	728399940	587790085	589504032	686487348	379720322	645433043	1248369808	0	701167163	500090369	596771044	1272794981	1828541961	872642356	870322224	481946619	0	1910703653	5186020860	585281542	487585723	1298338826	1712445035	1626026352	2521452813	1090602584
adenosine_13C8	0	0	0	0	6132	0	0	11226	0	0	0	0	0	7524	0	0	0	0	0	0	0	0	0	0	0	6869	0	5367	0	0	0	0	0	0	0	0	0	46065	12877	13882	0	66900	101393	0	0	15594	92114	0	137473	26702	48325	26859	119394	70590	0
adenosine_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	24575	0	14101	0	10264	0	0	0	0	0	0	0	13605	0
ADP / dGDP	9160730	23740135	48544660	39334521	39899029	38964021	16379898	17554422	39210882	23495425	38773055	62218475	16522969	32616155	28030550	20237628	35170139	61748771	23343645	25556148	55281816	26953602	60461462	56870283	35808726	16757250	31941806	39164503	45657077	47529716	16715259	27201784	35896940	27670782	22073089	16613741	52855557	98514403	73864278	59678668	44024702	98835541	114533906	129004182	72541317	73912609	127776464	113483673	136208591	73086014	55799381	75700557	35711764	116753892	64485783
ADP / dGDP_13C1	951862	2458975	5151038	4276193	4117678	4512415	1618693	1675192	4161337	2356767	4103530	6443174	1660728	3292735	3035782	2158622	3551013	6534516	2439626	2740646	5746901	2815034	6407474	6044954	3891292	1870060	3400777	4004511	4810078	4919668	1874185	3027093	3598074	3050894	2358697	1549327	5559654	10145786	7402235	6286418	4620839	10101406	11501755	13141147	7244873	7747144	13412735	11784274	13869747	7348375	6011756	7829507	3662519	11672464	6585298
ADP / dGDP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6020	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP / dGDP_13C2	0	99952	468674	569288	287908	502939	82810	180268	471260	132589	235648	783164	0	373566	293574	72676	322368	252109	334732	237444	563795	181830	283024	619976	777291	233447	468152	327085	322448	593223	96724	170688	328166	283022	184147	214268	720469	1592933	883557	1120045	1066634	2236066	2388249	2558047	1152368	1750491	1836817	2234090	2532103	1074581	1295275	1742683	700282	2419620	859940
ADP / dGDP_13C3	0	0	47094	0	0	31252	0	0	54513	0	19401	47700	16046	31379	0	0	0	151146	46132	0	161877	10944	123768	155520	187993	68113	180308	172358	135015	311819	0	0	0	0	0	0	83006	297783	121147	113234	245035	399678	590267	590238	189089	326555	544108	510140	487518	101882	588233	781414	322279	891383	323434
ADP / dGDP_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	19074	0	0	0	0	0	0	0	0	0	0	54532	0	81906	42369	15320	67950	0	0	0	0	0	0	0	33258	0	24842	162925	147958	161005	196933	97795	274043	254919	98313	222131	46530	407153	326085	111406	336639	180828
ADP / dGDP_13C5	0	0	0	0	0	0	0	0	134872	42415	0	86125	0	106018	67770	37527	0	387013	116861	59918	537831	206561	372431	383446	759638	227642	1221851	819412	905099	1402584	0	0	0	0	0	50397	236517	526602	457960	132101	955923	1597219	1703864	1917269	716110	1197528	2367949	1487270	1792957	477096	3171806	3796612	1742222	4362328	1390799
ADP / dGDP_13C6	138387	38186	64550	0	0	35600	13030	0	0	0	0	17180	29415	0	112129	0	63727	8669	0	0	0	0	0	0	0	0	23051	28644	18296	29807	0	0	0	0	7285	0	0	15020	0	0	0	97682	28117	20470	19475	38009	84409	74347	25606	54303	162177	120053	10492	168572	16299
ADP / dGDP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	14161	0	0	0	0	0	0
ADP / dGDP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ADP / dGDP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9262	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AICAR	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AICAR_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AICAR_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AICAR_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AICAR_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AICAR_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
a-KG	0	0	0	84320	0	0	0	0	0	0	106536	0	297341	99737	196131	213696	95015	255750	941369	631113	1233982	733562	957026	1045042	1933296	2873583	2822345	1954056	2337906	2442186	103101	88546	0	0	0	94784	102059	129261	601909	231917	86829	652530	1260896	425482	0	97377	316087	326992	108480	0	0	704883	783152	671131	74244
a-KG_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	32219	32363	41902	0	170627	145971	147498	82699	270330	164394	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
a-KG_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
a-KG_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
a-KG_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
a-KG_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
alanine	8261277	2995093	11681421	8056704	5876390	6267289	9109245	5518282	5918738	5899262	7409200	5039639	12592258	4182322	6402794	5577562	6795824	6842390	45737665	24540791	45531482	35987777	52552707	68280176	59620611	274953653	61070815	69397619	50390840	34768441	4996416	9818697	3685034	6225723	6822233	38211103	17814738	42610565	37316760	29917042	32203213	41336968	60155606	25434528	23431916	20127016	23019389	28466024	33099383	15733856	15204218	120004142	29130561	51909265	8913685
alanine_13C1	211520	84319	0	265649	47180	100167	402361	0	0	0	308818	0	220197	63642	0	105903	0	90530	1671388	946204	1448103	1278393	1665041	2121965	2113032	7914219	1921797	2139508	1581138	1332295	0	0	0	0	0	1118848	512100	1266827	701851	1000255	812379	670999	1855602	880406	585860	474092	492301	1248660	737791	169394	171918	2649972	1410983	1719756	399761
alanine_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	14609	0	28987	62547	12965	16036	86813	77949	45463	12114	59280	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
alanine_13C3	0	0	0	0	0	0	0	0	0	150034	99604	111389	228279	0	0	0	0	0	1124203	617667	1342215	1386994	2210002	1504400	2536942	1218258	2283680	2492430	2857676	1902245	0	0	0	0	0	152579	201505	118010	0	0	371392	203581	1032985	258152	94422	405639	213335	650690	408370	106603	50080	197670	1073633	207270	0
AMP / dGMP	54759	0	292712	0	97845	462488	165341	0	724835	237889	104547	442163	212610	316473	45467	249799	179913	590426	454139	14352	797235	643144	1030966	1049406	499132	581538	383157	569554	647183	417932	0	15202	0	54991	0	0	2871000	3482646	1595987	1167051	1588525	4050712	3617251	3943270	1615969	1779317	4524233	5902683	5421964	1848076	1553212	1448798	7829445	5261587	1810493
AMP / dGMP_13C1	0	43166	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	58366	0	0	15266	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9055	13499	71433	149006	0	48869	102062	78132	36320	10178	17742	0	694204	36495	0
AMP / dGMP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	50984	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP / dGMP_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	45913	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP / dGMP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	28730	0	0	0	0	0	0	0	44043	0	0	0	0	0	58600	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	39546	0	0
AMP / dGMP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	52035	0	0	75431	0	0	0	97526	47037	0	0	0	0	0	130944	0
AMP / dGMP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6266	0	0	0	0	0	0	0	0	0	0	0	0	0	0
AMP / dGMP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	48931	0	0	0	0	0
AMP / dGMP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
aspartate	54254234	45253031	32219987	41010265	57465286	37748441	50337924	38832787	24716732	31090924	43379171	31571955	56810504	33075690	32783988	36405330	46818455	30682195	41516115	36817677	25144760	34005378	41782105	35287754	30600034	52197394	29874446	35023138	37089352	35036820	23589780	20031464	20227880	23349774	18170087	60294227	35949086	29943551	48102582	33015896	25615391	37623563	29943853	39677284	38473797	27109802	38665721	47813586	39996008	34372279	30646787	51214869	40703822	47847400	26491430
aspartate_13C1	2099075	2215488	1296676	1521215	2132814	1384374	2642526	1927432	1152784	2792305	3935536	1452905	3105335	1734677	1319802	2647763	3545785	1457676	2008233	1776884	1202414	2659181	2935982	1618266	1954421	3022156	1335623	2266809	2838413	1532071	744504	668497	862146	863713	685524	2339808	1729584	1281425	2988224	1527320	1768620	1912851	1321117	2075326	1970985	2061713	1661102	1926568	2079745	1554199	2818619	2466477	1783306	2650977	1441845
aspartate_13C2	0	0	0	0	0	0	0	0	0	0	3153558	145306	2870525	1139304	166861	0	3245403	93060	3605069	605274	0	0	2676083	69768	1241821	0	0	1628246	2315576	0	0	0	0	0	0	353696	225515	322706	1187424	199883	1088744	206305	495701	1022673	642216	800250	285293	312157	936875	0	1828888	349824	0	986493	209968
aspartate_13C3	2099075	2215488	1296676	1521215	2132814	1384374	2642526	1927432	1152784	2792305	3935536	1452905	3105335	1734677	1319802	2647763	3545785	1457676	2008233	1776884	1202414	2659181	2935982	1618266	1954421	3022156	1335623	2266809	2838413	1532071	744504	668497	862146	863713	685524	2339808	1729584	1281425	2988224	1527320	1768620	1912851	1321117	2075326	1970985	2061713	1661102	1926568	2079745	1554199	2818619	2466477	1783306	2650977	1441845
aspartate_13C4	0	0	0	0	0	0	0	0	0	0	76075	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
ATP / dGTP	265086477	221916478	260319121	269064057	364618576	308789404	110987181	96266732	188251077	114595688	283590878	264723906	121011148	170584195	303477491	115878323	324846909	257947037	128710676	165945931	240572817	117814596	375588189	250241750	208672236	97146927	252218677	225720079	331419409	234557672	203753076	296496852	313373041	315132787	209722640	150719496	282177000	243861271	305419960	182205839	141891539	169266235	157143530	186156584	127681934	121104514	195728510	160595816	179557802	163852029	159098657	185398440	78134457	210304002	114413381
ATP / dGTP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6208	0	0	0	0	0	0	0	0	0	0	4669	0	0
ATP / dGTP_13C5	0	0	0	0	0	0	274173	243341	963201	477548	1005576	1023132	1116948	1307310	3752829	871936	2351754	2750214	877812	1008291	2478211	1018598	2566545	2038711	4960316	1787385	9152334	5080907	7233839	7946032	0	0	0	0	0	1105729	2288129	1597903	2168267	666913	3265936	3065153	2484850	3096570	1297767	2154557	3804510	2172693	2684872	1264721	9078318	9317075	3832516	8215760	2619041
ATP / dGTP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	9767	127627	0	45531	79380	0	0	39874	0	9224	37787	226283	49251	531383	264522	376886	415574	0	0	2981	0	0	0	14127	30044	40871	0	80021	80678	35785	145061	34811	93179	187180	0	48431	0	559524	570124	208362	446559	95058
ATP / dGTP_13C7	0	0	0	0	0	0	0	0	0	0	0	17002	10825	204	31605	0	0	0	0	0	9154	0	0	0	10467	10921	162254	23038	18305	52853	0	0	0	0	6633	46875	0	0	0	0	12677	0	11147	0	0	15248	11423	12721	0	0	117113	99678	13280	72122	0
ATP / dGTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5633	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	11956	32240	10441	0	0	0	0	21596	11401	7841	0	0	0	0
ATP / dGTP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	12336	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6535	0	0	0	0	0	0	0	0	0	0	0	12043	0	0	0	9111	0	0
choline+	83332051	150721292	134911490	148281365	143909645	5103498	38167826	127345557	151368500	138434929	206649420	209781447	79160497	263541088	35024278	102581210	197667119	271330908	275535598	380923408	354975266	281251091	560110933	466239806	468866062	336686806	482727981	656411516	492881744	475244523	137997009	183080946	246640291	179612819	208975258	520814268	249554766	310847382	1630957199	251992942	139239720	118027703	274511668	133810734	82878279	122093621	130796878	150464342	153780368	154141900	164046958	128685768	156712073	129596978	117128024
choline_13C1+	3745799	7528881	6519361	7207446	6991725	95128	1690237	6360225	7391884	6996236	10067771	10454138	3557510	12863158	1478036	4846982	9913104	14100568	14044279	19303919	18551012	14151980	29944145	24517020	23835235	17575195	25308534	32074859	25329694	25116128	7217654	8968244	12991999	9124016	10365306	26451193	12325147	15635730	12304987	12388193	6824127	5758797	14430461	6191209	4335265	6492275	5899666	6126101	7235033	6954296	7291874	5652794	7419276	5595048	5704151
choline_13C2+	74984	655152	51939	69932	72633	NaN	11219	72479	59321	96963	193455	95748	53253	171728	39530	33391	108929	167107	253369	290277	305535	166419	385908	2569786	421746	216250	347809	305435	289206	370318	78329	95183	183565	103322	131683	452097	156714	266217	1504216	104667	11226	NaN	113643	NaN	20123	78922	NaN	25326	73959	118757	72655	NaN	70059	NaN	NaN
choline_13C3+	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	68286	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
choline_13C4+	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
choline_13C5+	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
citrate(iso)/citrate	210798814	164591243	56253470	143079347	275808573	69364714	77341105	71986662	209183193	84866867	208567644	123425902	134414608	204370984	100807860	76118457	270815171	122788783	104432324	141706692	75101396	75571285	366282839	101764381	234741146	108602745	100183099	158097061	281000739	83980913	96075068	144687388	134127865	218104653	107485283	176850637	216623227	167192044	291541198	180916785	282572602	337239114	269706671	517482523	280270158	159409721	234580589	201780806	370422879	210222231	200466060	397446585	71784379	475005389	157917017
citrate(iso)/citrate_13C1	12298895	9273097	3227326	8143674	16165429	3940756	5591614	5077947	12879669	8561462	23942073	9089530	10795807	16826345	7261373	8669693	30763036	9592933	7604565	10238210	5280803	7763649	42395086	7996057	21636964	8929314	7337634	17135724	32342425	6968354	5658343	8602453	7754535	13066610	6353078	12528537	16564044	12922615	28839282	12879318	27069919	29577548	23910408	52005002	23340154	14967882	19181414	15457024	33458505	15026424	23196084	32621769	6062509	46560864	12708380
citrate(iso)/citrate_13C2	0	0	0	0	0	0	4362726	4054524	2995452	15706246	50332332	9724768	23099771	29187087	8217553	25014190	96197902	16457868	8634019	10221782	3968348	14978132	93167711	9120175	30628143	10874578	6174655	38018977	78507133	8404460	309105	156062	85913	8125	0	6340517	16229743	15734231	46291306	8329916	38842503	50984831	43828675	100298557	29938613	15926554	21877079	15237496	43641980	10411273	34028130	34016189	7196147	69368395	11780360
citrate(iso)/citrate_13C3	0	0	0	0	0	0	181037	40222	178669	2656066	8611829	997529	2129350	2735954	1063865	3962527	15016054	2080717	872251	952963	603807	2374191	14858204	1255537	4432597	1358858	1263047	6874721	14200837	1441456	0	30266	0	0	0	641755	1853773	1611878	6510305	597243	5954392	6259767	5133030	13994206	3380252	2628770	3533834	2371695	6491747	1501913	8033515	6322747	1176258	11767533	1749041
citrate(iso)/citrate_13C4	8566	9435	0	0	0	0	10182	18143	6996	1753207	5263993	342259	1195038	1284829	271749	2888299	11398678	1186711	171902	242033	134824	1346791	8694012	542330	1994735	412550	259333	4451629	9058518	523574	18688	0	0	0	0	129598	674340	644299	3593805	87161	2929424	3186345	2531651	8201146	1375026	1195353	1599012	787714	2939602	264203	4011089	3070572	303120	6028036	480718
citrate(iso)/citrate_13C5	0	13735	0	11977	0	0	50725	64687	12519	388912	1158678	13319	216120	64070	16803	817504	2734601	50214	86160	20261	0	424365	1981821	70333	262151	180924	60023	1058746	2410576	89341	20401	26703	47855	36657	0	0	63032	62652	523277	5958	464742	355369	330278	1562673	101395	170216	247546	140665	491007	56196	1049258	623544	141870	1366660	80291
citrate(iso)/citrate_13C6	0	0	0	0	0	0	0	0	0	0	9694	0	0	0	0	0	0	0	7747	0	0	0	42702	0	5930	0	0	33135	67615	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10072	0	0	0	0	0	0	10340	0	0	9966	0
CMP	99593	96360	36660	130283	74324	0	0	90640	281245	52802	56905	493002	35128	417672	8321	0	18831	366958	478700	593781	724505	212223	647096	495709	893358	524051	696525	530551	443533	662978	0	47665	229158	47036	81145	299573	1350820	1895889	1530054	1411483	25687695	11078786	17048588	14606895	23899557	19255162	14322804	11252706	14269451	8803668	10318122	18212144	1358214	12073753	19392852
CMP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	11790	0	0	0	0	9769	0	9933	0	0	0	0	0	0	0	0	0	0	12828	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CMP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10101	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CMP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8053	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CMP_13C8	114793	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	11216	0	0
CMP_13C9	0	0	0	0	0	0	0	0	27679	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Crotonyl-CoA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CTP	31420687	27293316	15242353	16965607	23704086	16136250	13747983	11048424	11452845	7065038	16180518	15071244	17886259	29706737	27492693	10016798	25458060	22075790	8388696	13837413	14209590	5436208	14001222	10917575	21934215	9642049	20016733	16696960	24145326	18519753	21997910	19077020	16440498	19373757	18390703	16815517	18302231	13847438	18717406	15731168	19840816	16640951	13340850	15944838	16135131	12467902	10605351	10266955	9506100	11471318	18138426	13506762	5555980	14050296	10418546
CTP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CTP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CTP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
CTP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
cystathionine	492571	373528	482582	472838	609554	528659	196359	166261	339537	191780	383524	454835	216422	334172	520199	231841	833256	507126	210619	283835	516363	135063	477264	384849	416811	254201	485555	411572	531151	504651	141483	245658	159843	393747	76912	1143477	385136	342239	419234	344996	327371	634102	547523	748761	558011	308443	731649	468161	701463	436459	371409	1297487	292929	879698	435297
cystathionine_13C1	0	0	0	0	0	0	0	0	0	0	9883	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9179	0	0	0	0	0	0
cysteine	0	0	0	0	0	0	0	17235	64636	0	40754	12131	0	47860	0	0	100624	43153	458808	509603	546532	168475	637946	731781	426926	655575	487191	509595	363690	431992	0	0	0	0	0	1499604	541954	1627243	1512309	833261	5156586	2831557	10612426	4288132	3333015	4212891	5707019	5762189	7080144	4208073	3525523	3677044	4033077	6233460	2523480
cysteine_13C1	0	0	0	0	0	0	0	0	41262	0	0	0	9450	0	0	0	0	0	12873	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8032	0	0	14403	0	70629	0	0	0	0	0	0	0
cysteine_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
cysteine_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	32132	0	12212	0	0	0	0	19205	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dATP	15812	0	20543	0	17372	0	0	9011	14687	0	0	0	0	0	0	0	15820	13788	0	10637	12697	0	17319	0	0	0	32162	0	15954	32059	0	15362	21379	18766	0	13047	136347	131112	202458	112708	10022	13792	0	0	0	0	0	0	0	0	0	0	0	0	0
dATP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6277	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dATP_13C5	0	0	0	0	9397	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dATP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8181	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dATP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6091
dATP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dATP_13C9	0	0	0	0	0	0	0	0	0	6942	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8698	0	0	0	0	10603	0	0
dCTP	1351052	946444	657469	624470	915842	727157	397976	308707	409950	297750	722640	686129	597323	674055	979600	323911	1042772	764052	435710	452435	545322	201184	795606	546923	926974	265086	710858	540771	993150	706989	632218	718880	971326	769728	670846	460318	734926	705351	642642	574099	596959	587737	579686	566573	539432	341346	470587	529758	429257	487632	580286	563868	215276	632160	433005
dCTP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7573	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	11076	0	9489	0	0	0	0	0	0	0	0	0
dCTP_13C6	0	0	6771	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	11620	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dCTP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dCTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8217	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dCTP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
deoxyguanosine	2232532	1310249	2427783	2869443	5692550	1938763	6391563	4138780	5593678	3998332	8302911	7602647	13268074	9604198	7596843	5133435	9552002	5859646	2886560	3018179	2887603	1886125	2204285	6725343	2937615	2926228	7215480	6073931	5665804	7192248	17590821	11894443	6323847	14404425	9493232	6509999	17573505	16939516	29680791	20644306	4821826	19068331	8616844	20745098	24088759	10231314	18372586	14645966	20723516	20310943	20166621	16329421	16241253	30836028	18386880
deoxyguanosine_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6834	0	0	0	0	0	0	0	0	32378	0	0	0	0	0	30767	0	0	0	0	0	8126
deoxyguanosine_13C5	0	0	0	0	10265	0	0	0	0	7362	0	0	0	0	5682	11181	0	0	0	0	0	10781	4813	0	9002	5318	0	81089	26037	23321	17239	0	0	6557	0	0	0	0	0	0	0	0	0	0	39163	26749	14679	20681	11628	27346	10888	10659	399316	0	429750
deoxyguanosine_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	38488	31019	4550	0	0	21053	5606	60488	41567	0	20029	64141	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10738	0	0
deoxyguanosine_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	20624	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
deoxyguanosine_13C8	0	0	0	0	0	0	0	6717	0	0	0	0	0	7524	0	4957	0	0	8507	15997	0	5848	0	24648	0	0	0	24123	37516	0	0	0	0	0	0	20054	0	0	56222	69463	7010	83359	101431	296807	35896	90003	45837	273489	261108	335545	314817	181491	71272	2306340	97516
deoxyguanosine_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	14672	32220	0	0	270969	207620	82376	141987	229891	32616	105946	118567	282847	56102	216923	69492
D-galactosamine/glucosamine-1/6-phosphate	161739	255413	167301	174717	420703	84298	42599	22218	391022	0	64049	48590	17857	8713	18434	8229	29699	55435	8727	8508	0	0	29562	10212	51104	32082	28892	10088	48813	0	0	27420	20378	24331	22697	0	36174	22270	10252	0	44822	22745	12303	10720	8183	9687	22953	0	9267	19540	62850	40410	0	34582	4641
D-galactosamine/glucosamine-1/6-phosphate_13C6	0	0	0	0	0	10230	0	0	714	0	0	7639	0	6838	8759	0	25931	117822	0	0	0	0	0	0	0	0	22143	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	31504	16007	18623	0
D-ribose-1/5-phosphate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	53033	0	0	0	0	0	0	0	0	0	0	0	0	0	18854	0	16336	14081	0	0	0	0	0	0	26303	80192	42811	0	18174
D-ribose-1/5-phosphate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
D-ribose-1/5-phosphate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
D-ribose-1/5-phosphate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	63391	51300	0	0	0	0	0	0	0	0	0	0	0
D-ribose-1/5-phosphate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
D-ribose-1/5-phosphate_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
D-sedoheptulose-7-phosphate	191039	153506	229453	263640	357671	406335	26439	36689	173790	29016	247267	286834	52624	23284	331331	85951	259171	269130	10786	97985	220455	47438	277565	261367	156589	305263	366901	128814	291309	274050	226021	472527	684136	638860	127608	10371	380055	417125	420767	53339	24915	677298	512651	728833	197799	90282	478586	462318	448538	72246	50624	609441	351049	923157	167663
D-sedoheptulose-7-phosphate_13C1	0	0	0	0	14113	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9293	0	0	0	0	0	7396	0	0	14188	0	0	0	0	0	0	0	0	0	25634	0	0	0	0	0	0	0	0	10636	0	10867	0
D-sedoheptulose-7-phosphate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10072	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	12912	0	0	0	0	0	0	0	0	0	0	0	0	0
D-sedoheptulose-7-phosphate_13C3	0	0	0	0	0	0	0	0	0	0	9044	0	0	0	0	0	0	0	0	8670	0	0	0	0	0	0	64791	0	11482	6355	0	0	0	0	0	0	15550	11957	13352	0	0	13116	12425	0	9508	0	15027	9540	9119	0	0	50148	50528	13714	0
D-sedoheptulose-7-phosphate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9710	0	0	22021	0	8345	31730	0	0	0	0	0	0	10181	14212	0	0	0	12960	19030	0	0	0	16746	29485	9749	0	0	98561	21513	58316	0
D-sedoheptulose-7-phosphate_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9538	9422	0	0	0	11066	0	0	0
D-sedoheptulose-7-phosphate_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	22071	0	0	0	0	0	0	0	0	50130	0	0	66595	0	0	0	0	0	0	0	0	0	0	0	0	42709	15615	0	8221	8973	0	12693	0	0	63878	65343	22648	0
D-sedoheptulose-7-phosphate_13C7	0	0	0	0	0	0	0	0	54374	0	19823	63087	29068	103882	173175	54235	90395	342926	11908	0	150720	0	54174	158719	10199	14896	879315	229696	396524	686772	0	0	0	0	0	0	144255	191863	126222	0	17893	373968	518218	391853	0	7721	500846	315267	205866	0	36974	1204980	1153342	1088177	37299
dTTP	0	21599	24058	14284	29671	8444	10995	0	17450	10146	60263	20092	14461	0	9006	17391	71059	26881	0	9548	24633	10062	77098	23404	32654	0	25100	26129	31075	36613	28426	19288	11323	48271	8416	0	47931	11733	49705	7612	37121	14493	6905	37923	7442	7575	7990	0	8097	6499	23122	28036	0	32112	0
dTTP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8281	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9539	0	0	0	0	0
dTTP_13C5	13199	0	0	0	0	0	0	0	0	0	0	0	10117	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9712	0	0	0	0	0	7668	0	0	0	0	0	0	8378	0	0	0
dTTP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8399	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dTTP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5396	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5546	0	0	0	0	0	0	0	0	0	0
dTTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10317	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8168	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dTTP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dUTP	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dUTP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dUTP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7112	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dUTP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10056	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dUTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	7229	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
dUTP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
F-1,6/2,6-P	2073640	2299521	2162522	2320710	2984465	3190280	1124198	945026	1599089	943049	1347150	1469018	960105	1196350	1987757	1018744	1408633	1238643	502040	1024664	1126391	595373	1347020	1013674	1209757	554639	1208320	1308228	1720837	1292673	1839849	2269961	1875195	2696867	1972074	1410063	1636718	1978542	2431375	2011685	1325426	1840473	1324904	3004200	1481226	1066388	1394185	1534689	2175123	1734225	1108740	2454211	1075445	2540154	1559384
F-1,6/2,6-P_13C1	16306	6722	56028	16741	65729	12859	0	5198	13472	4612	12863	7297	0	5387	12215	0	23142	25354	0	6124	5444	9749	5062	0	11593	3483	21277	0	5829	4263	22361	31790	46625	75675	11220	4911	13133	24053	63325	36327	15954	17254	33955	42431	0	10669	35194	22337	22336	0	9438	31680	9891	52956	20056
F-1,6/2,6-P_13C2	0	0	0	15495	11988	6806	0	0	0	0	8235	766	11030	18724	44936	5769	21629	37600	4569	16710	17301	7779	39638	5093	29163	14487	54200	4284	53365	53300	19083	11118	30924	16932	12136	36094	5655	0	5076	4163	24730	21025	68379	57385	27895	37698	17577	0	5512	8720	40018	57593	9832	58920	25649
F-1,6/2,6-P_13C3	0	0	0	0	0	0	0	7670	63101	19305	69838	239015	46175	330212	1878230	426194	1875693	1310569	43312	221780	300278	70068	323318	48107	753856	351754	1034147	1099756	1509249	1936121	50340	0	4791	0	0	50016	73923	22713	55386	6976	295523	2022628	2295359	1817832	890929	579424	947851	1000823	860474	781804	1399832	2935067	1423965	3092814	1228032
F-1,6/2,6-P_13C4	0	0	0	0	0	0	0	5289	0	5638	0	5115	0	0	47947	0	9573	34364	0	0	0	0	6714	0	5111	5016	5454	5713	32065	32439	0	0	0	0	0	0	0	0	0	0	0	43319	96777	54362	0	5602	18209	12538	4812	0	7064	58576	37314	177305	4564
F-1,6/2,6-P_13C5	6993	0	0	0	0	0	0	3716	6244	11755	5750	38030	0	32777	492639	10375	422548	475700	0	18577	53985	10838	25283	27731	101206	8428	325513	241517	578754	786086	22278	5459	0	0	0	4176	4545	10262	17661	0	21097	594298	642375	829776	150012	91371	326687	277405	222105	95284	284064	1081857	681188	1093472	352254
F-1,6/2,6-P_13C6	0	0	0	0	0	0	0	5930	646041	222251	612460	1252294	778116	1633879	3617193	1572847	3566575	4034088	589693	805564	1189937	454269	1299966	575329	2204282	1507959	2625886	3209257	3541493	4761537	424270	39129	0	0	0	318056	591637	480404	1030050	53940	1307056	5979121	7407919	5116058	2191885	1776259	3319819	3338724	2280301	1823523	2678702	8935620	5767108	7785669	3970895
F6P/G1P/G6P	3610872	2606270	2875908	3583790	5440353	3207530	1287521	1255104	3830290	1886337	2632109	2788732	1572573	2351666	3122468	2238402	3333478	3282078	2092921	3324826	2420194	1490128	3296922	2740372	4095871	4732831	3679411	2994142	2944291	3198712	4778166	5079940	5484154	5427059	2962467	2303291	4801290	4877069	4809005	5109863	3289343	6435759	5492129	7092954	5025444	3981243	6751243	6234349	5814068	5881181	4502495	10416856	4231245	9846186	5943579
F6P/G1P/G6P_13C1	56156	10102	23091	56888	141720	9141	0	11885	154822	14360	54045	56776	9558	28539	23716	25195	79982	40357	0	106695	52368	38201	66595	70734	135192	143811	94267	64134	51035	102978	163458	70164	234090	192144	34952	15705	235720	183718	166262	221830	67221	251793	178731	326424	126800	190889	298229	282866	209700	161615	113059	498625	107100	431528	233197
F6P/G1P/G6P_13C2	0	0	0	0	8480	0	0	0	0	0	9281	0	0	0	0	0	0	0	0	0	0	0	6600	15360	0	0	8008	0	818	0	0	5509	7635	0	0	0	14828	21815	10529	17134	6763	7059	17713	13108	8322	65428	0	16350	10334	9901	27339	16150	11033	0	27953
F6P/G1P/G6P_13C3	0	0	0	0	0	0	0	0	29969	0	134276	42963	0	0	61071	0	37831	80278	11638	7614	33417	10528	95163	24863	26684	0	309307	25040	106459	196277	0	0	0	0	0	16332	245954	267560	290489	143821	11270	225610	444785	135494	13135	146628	122683	121461	56207	29762	30782	365852	428369	219000	13812
F6P/G1P/G6P_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5949	0	0	0	0	0	0	0	0	44842	18218	19088	0	0	0	0	0	0	9112	0	0	17475	0	0	12127	0	13765	0
F6P/G1P/G6P_13C5	0	0	0	0	0	0	0	0	0	0	14073	7678	10678	0	46893	24095	66764	86834	8572	0	0	12778	47119	49425	6938	0	214775	23502	47422	68780	0	0	0	0	0	19654	586180	404469	545674	314104	0	58766	222097	141903	11498	52888	88205	89645	65079	66080	45707	395770	268016	248918	17774
F6P/G1P/G6P_13C6	0	0	0	0	0	0	243243	212643	741923	495983	1290822	1027447	565505	740455	1938174	889709	2443909	2374225	321944	565076	959683	430227	1385453	1503460	919759	462388	4112574	1586039	2134474	2780528	0	0	0	0	0	396675	9919276	7056466	9994687	5376668	1358737	3381903	4595069	3702574	1302771	1160402	2809493	2616383	2586762	1410427	1835362	5470362	4484021	4799933	2040640
fructose / mannose	34984197	25448398	19923408	18588339	22239448	9259519	20093485	12901096	41356680	28192806	25210254	24543878	47176403	27697656	38591417	23819064	88254145	26565964	19019831	23835458	11026252	10864227	23629286	28971932	18677786	37422274	26551799	16764060	21481704	16422327	21521901	18590486	12922494	18450465	12196291	221940201	47970062	16727753	54415641	38460385	52261407	43322860	29101254	53789838	49525422	14441805	23991225	22354299	11352887	20651580	12091217	91043721	15124917	23361315	21527738
fumarate	849589	785889	1221137	644896	625062	1033993	842189	588115	820925	658347	501827	829587	1224937	511839	1543427	922483	840978	1236805	3634751	1750914	1821016	1719831	3774032	2306946	4250784	4197165	3375488	2478724	4592770	3002208	220371	682148	1023563	696127	317904	234783	1159735	1455442	1131010	537284	323452	1346402	2078391	1476828	941100	446778	1620103	2338542	1562003	1265891	714427	1868966	3424864	2610185	1474514
fumarate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	43199	0	0	107800	48419	0	26891	154348	0	242768	158623	39669	135779	231532	0	0	0	60002	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	128671	0	59619	0
fumarate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
fumarate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	24774	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
fumarate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
galactose / glucose	158624204	189450879	149878341	222751472	188239667	45477250	14467985	57584030	44281421	27820197	64345781	32060916	65918187	32318601	29939638	33680182	59087227	31602547	22992324	25605989	16179698	10587450	20036015	21574551	19996042	811321090	38056584	19107270	16872110	22319207	147244360	83664883	36728433	110346252	52981322	1337422544	78861113	37166978	74739494	116381863	80041849	280216782	48864092	186868684	190976396	20806464	40672362	37012089	29362632	45370037	20608129	1092988176	37247213	275371175	27840545
glucose_13C6	0	0	0	0	0	0	92655276	75706557	166945073	100985155	123970212	135122830	326787372	191825538	281252527	217821104	889415490	125053151	197076563	244923221	116416064	91718080	190765509	158401682	170043784	179062684	247719074	148310812	165678847	117925254	4310682	0	0	0	0	2507530605	370309020	131080079	387395466	280860273	506136362	346773792	295362854	355152563	711447889	123958675	211958091	176437478	90437004	249894950	100070399	154274836	135771765	111171395	132626637
GAP / DHAP	0	0	0	0	73699	0	0	0	0	0	0	0	15010	0	0	72539	0	0	0	5388	9937	7062	10008	22587	24575	0	13593	24751	0	13394	6397	15201	35013	0	0	0	0	72483	0	14270	29755	0	13903	26018	3121	18206	12972	79786	30885	0	24554	60339	69589	2481	23512
GAP / DHAP_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
GAP / DHAP_13C2	0	0	0	18033	0	0	0	0	11101	0	0	0	13152	79266	16470	0	35252	0	10030	0	0	0	12089	0	21297	0	0	0	12684	0	0	14255	0	15182	0	0	0	0	13272	12931	44703	49227	78850	160217	125026	64960	12725	23159	144384	49754	79541	37209	0	128895	70268
GAP / DHAP_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	166765	0	11287	80101	0	0	0	0	0	0	93498	175870	103534	0	0	68049	171349	159435	0	0	0	56583	0	0	0	648769	932189	553486	0
glutamate	143591118	96683793	131569505	111323970	140080681	132833229	125190077	76432931	88652580	87185176	97802632	99017658	148891164	83153763	147828640	125124664	127433878	118116132	159480238	99555061	112858014	116558208	123898964	113123111	138157925	179587789	158781049	132877099	158495181	149376410	68742529	88182454	91920690	85416115	59060609	91959285	114813923	113041201	114492504	83261833	91902695	169947390	145226410	152754765	128936614	90630598	150481266	191283573	143478519	118791307	138035135	242416028	227394995	243094172	113485869
glutamate_13C1	7551683	4653368	6882790	5181918	7039178	7029090	8219454	4725063	4964299	9004946	9759229	5921432	11157499	6418176	8459033	11175267	11761860	7217884	10620733	6399092	6774337	10083737	11094008	6701834	10429112	14115012	9243561	11834628	15001316	9143052	3482067	4177905	4683723	4246076	2931680	6249879	7223665	6671644	9302791	5124810	7873861	11007958	8960005	11531160	9005719	7692907	9473922	11183601	9923397	7351395	13490926	14980246	14778827	17899536	8055921
glutamate_13C2	0	0	0	0	0	0	7492403	7549433	2462745	19469908	15424227	3546803	20042948	7946089	5504563	33602963	22052917	5168366	15120137	4707539	2026053	16296344	15594407	2769637	10153035	14422046	3776034	17531217	22706375	4253453	0	0	0	0	0	2304491	4847717	4329395	9586511	2261822	9078204	9250766	7315917	13959194	8066175	5178100	5221381	5440824	7846435	3731850	14700611	8565215	13164221	15250160	5453268
glutamate_13C3	0	0	0	0	0	0	346630	1195380	82402	2286385	2524931	85705	1533660	312645	247780	3997431	3343458	394218	1037721	110447	56823	2198107	2183526	80878	1193413	1662059	287811	2752554	3548913	231122	0	0	0	0	0	539344	0	396269	1183961	0	1058656	363713	516891	1693094	447505	581897	295450	468950	670574	82348	2758231	1163582	1341162	1967081	338603
glutamate_13C4	0	0	0	0	0	0	0	0	0	1077460	1252603	0	445912	95294	0	1823579	1652394	0	71667	0	0	804320	1151676	0	339907	353214	0	1434077	2184227	0	0	0	0	0	0	0	0	0	428463	0	258605	86486	137605	870769	0	0	68560	149904	66595	0	1287231	428805	220753	1314122	0
glutamate_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	364503	0	0	0	0	0	0	289544	0	0	352440	0	619772	732887	246578	445461	409749	0	0	486266	0	0	0	558825	0
glutamine	24997859	20824076	18444646	19214997	21043816	18939426	19622811	17916979	17880717	16110206	23985243	17415544	33501985	20818106	27763113	24404900	44327566	22167331	35422625	24281030	21163564	21603824	35009139	25022953	25916225	77674484	31006376	27862053	37767740	26576306	10535716	13361568	13760198	15775282	10599607	108432787	28273045	27789018	37445368	25652594	31007376	31749067	36061220	37555432	33627951	14849479	26197367	26389199	24862662	19381893	17985657	60628791	25701067	31562787	15482871
glutamine_13C1	673954	601451	475045	594945	407631	422648	899150	548139	583141	375637	800816	381227	1013987	495667	1072566	831488	2267670	739368	1322500	258782	792542	675784	1554626	814360	866143	3703044	1058223	1047688	1312007	909278	0	383038	267857	405521	0	5280770	693311	1143213	1538675	1013572	1626604	817761	1306866	1732302	1178904	116336	626290	1227150	1050639	384035	577565	3097463	1089815	915606	149006
glutamine_13C2	0	0	0	0	0	0	0	0	0	93406	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	91990	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	71202	0	0	0	0	0	0	0
glutamine_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	81147	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutamine_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutamine_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutathione	4509338	3625560	6163220	4356758	5748760	5335702	3629707	2232293	691987	2242230	4649904	3024978	1860369	1920764	4068001	1819469	1850133	3901744	5301240	3894235	5908115	5741798	9579018	7264336	5307676	1372371	8278163	5429252	9809732	7589306	1513434	4569828	4200542	4194850	1770437	0	7277302	8241086	8217110	4304874	4799651	11083531	13544165	10794298	6663154	4998213	11523469	13240562	10988712	6854793	5598858	8085184	11002945	11557741	5714488
glutathione_13C1	298741	118256	347420	0	0	112844	0	0	0	0	0	0	0	0	0	0	0	0	179791	0	419182	466347	1110083	223188	126103	0	591135	218295	822470	168990	0	140323	360677	149767	0	0	290297	676032	415907	150483	274316	740224	1311398	891244	135804	229585	584637	1396141	593190	256032	90403	386209	619302	1053156	363634
glutathione_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	233338	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutathione_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutathione_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutathione_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glutathione disulfide	35341327	34287813	28403426	39760732	47666989	50139674	13006859	13206382	55362570	25375387	40318060	58763593	30875000	34958677	71209031	34729978	85162205	56436988	25386970	25302610	40534927	17095562	49129875	39400818	30668067	22366587	42681881	49561149	46031078	42124958	26748157	40036651	44295583	47965307	30931373	14035010	31019709	12894189	18342438	20541105	4188313	9523858	6537518	9126016	3993217	2292858	6398438	6356168	8701975	4302884	2693845	18463537	6736515	11311473	4330714
glutathione disulfide_13C1	8125852	7841860	6639942	9218173	11077021	11672630	3036943	3116976	12535883	5935371	9394248	13708331	7280569	8360051	17030772	8180482	20542390	13353919	6128786	6017987	9395999	4149991	12202544	8985211	7388460	5295212	10255165	12286727	11340350	10007284	6128005	9266237	10218227	10849133	6989692	3395697	7088519	2955793	4243439	4839878	1028516	2145044	1657623	2184307	977694	540730	1534092	1517681	2147690	977043	609815	4385747	1620393	2864135	1075875
glutathione disulfide_13C2	0	0	0	0	0	0	0	0	0	8048	0	0	0	0	0	0	0	0	0	9482	0	5800	9788	0	0	36410	10207	2432154	194602	11527	0	0	0	0	0	0	0	0	0	12836	0	0	0	0	0	26389	0	10268	0	45518	78219	0	20953	148097	0
glutathione disulfide_13C3	14704	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	87201	0	0	0	0	0	264306	225003	0	0	0	0	0	0	0	0	0	0	0	0	7386	0	0	0	10199	6545	0	0	22589	15604	8457	0	35223	9496
glutathione disulfide_13C4	0	0	0	0	0	0	0	0	0	22175	0	0	0	0	0	0	0	0	0	16073	0	6579	0	0	0	0	0	6540	111937	0	0	0	0	0	0	0	8528	0	0	0	0	0	0	0	0	0	6677	0	0	0	0	0	0	13758	0
glutathione disulfide_13C5	0	0	0	0	0	0	0	0	0	0	9540	0	0	0	0	0	0	0	0	0	0	7852	7173	0	0	0	0	21366	46027	0	0	0	0	7755	0	0	0	9869	0	0	0	0	0	0	0	0	0	0	12166	0	0	0	0	0	0
glycerate	68099603	46501607	32357219	25395316	21788265	9053916	12538868	14282644	17349696	13855601	14947636	13757576	13052030	14379332	13455813	11273226	13388557	12436802	9499267	10984385	6125263	7810971	7002762	11250149	9684235	11501524	9608999	11017327	9077721	11041865	12309637	10508272	11756232	10577180	11981890	25745083	13171722	10567105	14698920	13461369	23990103	20778838	17047753	18607799	17848482	14544712	16329525	17277018	15737713	14422596	14228502	14297465	12510841	13697323	12882481
glycerate_13C1	1925369	1132646	721067	431742	423960	34447	154310	95725	128556	71716	60763	110265	88102	24253	59619	21164	29470	21893	91970	35583	27922	0	22783	141300	94074	113154	60909	120158	88441	103576	81700	28680	18872	43400	60562	376046	92362	12606	177926	65951	414516	150691	156988	117982	46762	118860	155708	134146	113737	109273	31702	83984	135735	88080	105743
glycerate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
glycerate_13C3	53545	39150	37132	12897	44782	42537	47635	124622	222152	336002	419748	489092	537264	507788	626888	662651	600898	862650	357383	669383	382035	728782	535502	628011	734204	538962	857506	774211	644708	913093	944280	577901	331038	473849	282183	572967	1839775	986726	1211462	1347531	1084725	1591589	969219	1803294	2060393	1243647	2221472	1502664	1921340	1458709	1928719	825531	3213083	1530514	1368325
glycerol-2/3-phosphate	914867	250565	15411026	631222	1626883	14276863	506649	258612	8216052	775637	769571	6341746	1117634	407818	12354322	1188840	1270091	9856705	634552	541933	6449836	688162	1195845	6286626	634017	653256	9324357	817833	1229720	9406607	1024792	6543948	10023707	2143968	418501	648710	7130981	7849810	2579537	970670	689411	7567257	11449988	2578880	368854	1285600	6216788	11378691	2496538	1054576	1899542	6630147	13896363	3175332	538226
glycerol-2/3-phosphate_13C2	0	0	0	0	0	0	0	0	45256	0	0	0	0	0	140363	0	0	70141	0	0	0	0	0	0	0	0	140791	0	0	86057	0	0	0	0	0	0	0	0	0	0	0	0	146244	0	0	0	0	0	0	0	0	74042	648704	0	0
glycerol-2/3-phosphate_13C3	0	0	0	0	0	0	0	0	7020922	209600	225323	5641021	130586	0	15158017	628051	801284	12150879	232188	68834	6910110	640639	705501	6458253	241923	0	15277060	927511	1260766	13117532	0	0	0	0	0	0	5498039	7759836	1266585	0	54653	9263528	14060371	2463288	0	705190	8300575	12891569	2543134	462148	1654062	11658998	23510376	4022020	395173
glycine	8377145	7052173	6631986	7490828	8363448	8129291	8789142	6039366	7265854	6746543	8251640	6760062	7622723	6725034	9529156	9691026	14058413	6639180	12762552	7212200	8413178	9200769	17215597	13140253	8877090	11994144	9801740	14545317	13295208	8417412	7194942	8020147	6796967	7217635	5264718	16200277	13300628	10246779	13592618	9683838	12877089	14776221	13701605	15384422	11940622	7805575	12428890	11392018	15522776	8098911	8799128	20008441	9070674	17912146	7916320
glycine_13C1	0	0	0	0	35749	0	0	0	0	33712	0	0	39457	0	0	0	0	0	36935	0	0	52933	46127	0	0	43813	0	0	42289	0	0	0	0	0	0	0	0	0	0	0	0	97576	0	59290	0	0	38508	0	0	0	58686	46313	32655	103599	37228
glycine_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
GMP	866616	763881	2431589	732693	842302	1835006	519147	682315	2067404	801937	841190	3364710	413655	1157963	914017	646417	1374629	2090531	773540	852288	2622491	1247504	1352426	2753155	1758483	289246	1365487	1804441	728547	2105867	623674	824514	1069477	918732	811450	666909	6829778	9910440	6282699	3842612	4007347	10042937	10451097	11219177	4326876	5365749	11263754	7645894	12694138	3121967	3605691	3257078	9095927	8550517	3119362
GMP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	14052	0	0
GMP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	33590	10305	0	11033	0	0	0	0	0	0	31782	121961	92942	0	13197	231771	269289	277380	0	42157	289061	95739	258825	0	185848	117845	843155	656998	10591
GMP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	13069	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
GMP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	91206	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
GMP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	12634	0	0	0	0
GMP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
GTP	49631439	37395629	48509781	45671582	64391250	59794763	19048000	14768180	31716184	17043770	45150541	46162764	23014836	39122669	64592691	21900763	59592998	62389935	14688458	24470742	38583145	16158344	48309916	39399118	41879368	14638884	49519796	36467828	59221470	48705095	35169804	44684791	46961047	42477943	31571647	17300912	47754691	41401616	48701773	29443348	26573119	32462607	28626933	32335316	22347971	15888738	28162582	26657324	24995970	23761095	27653351	27789839	16608050	31703954	18784460
GTP_13C10	0	0	15012	0	0	0	5764	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7921	0	0	0	0	9467	0	0	0	0	0	6193	0
GTP_13C5	0	0	0	0	0	8702	0	24816	195646	67951	162398	157919	254384	490737	1239674	239200	705130	924802	96922	147383	523613	189715	419321	337205	1418237	424843	3815993	1822467	2743108	3087774	0	0	0	0	0	0	574496	391045	637909	36546	478780	964065	749041	1021226	228738	319357	845804	505729	656091	258321	1773067	2598576	1475787	2683399	600511
GTP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	22983	0	104205	66897	58674	149798	0	8273	0	0	0	0	0	12385	0	13674	0	0	0	0	0	0	17502	0	13828	0	85356	0	30997	40579	8250
GTP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8922	21961	0	0	10151	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
GTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NaN	0	0	NaN	0	0	0	0	0	0	0	0	NaN	0	0	0	NaN	NaN	16377	17893	NaN	16589	21734	19842	9738	0	0	0	0	NaN	18107
GTP_13C9	0	0	0	0	8969	0	0	0	7545	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10319	0	0	23694	72404	26653	9852	NaN	15044	0	18128	8259	7909	0	0	33836	0
guanosine	284142	425782	389500	434691	503006	40793	105101	344129	359318	363401	856733	625450	310786	659895	245393	428487	790479	726142	359968	441196	303071	381211	681995	672278	497001	365585	694864	755150	757038	764382	132253	240913	273207	255753	214570	158498	15518575	16255584	29216084	11088114	2801074	8229723	4488497	9874507	4617069	3738081	10449155	5374788	10717069	4208575	4283504	2873717	3285612	10052387	2768799
guanosine_13C10	0	0	0	8360	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
guanosine_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
guanosine_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
guanosine_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
guanosine_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
guanosine_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP	24834	45657	0	31912	54086	0	0	0	0	0	10639	0	34779	0	0	0	37916	0	0	0	0	0	0	0	0	0	0	0	9558	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	12579	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7908	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	10366	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IDP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IMP	0	0	0	0	0	0	0	0	13671	0	0	0	0	0	0	0	0	58150	0	0	0	0	0	59235	0	0	15793	0	0	0	0	0	0	0	0	0	0	43982	0	0	0	0	16923	0	0	0	0	0	0	0	0	0	0	0	0
IMP_13C10	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IMP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IMP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IMP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	29039	30032	25550	55176	0	0	21757	0	0	25110	0	0	48832	0	0	0
IMP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
IMP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
itaconic acid	85511668	52556893	44563458	58509773	92708330	51153010	90660208	53315650	35400325	61537118	80850965	43313601	98281978	49760768	55800613	74980200	85709102	41083170	343003272	75931079	73127196	234384905	632427264	195829037	437345278	292654975	84364089	299931919	549488040	76283778	7109433	36134494	32684150	51282736	24996611	10968027	40240973	108579702	63388505	35078286	17536060	33092464	102414093	48230191	26167866	11200629	23267635	32450934	38290802	16946688	4969351	24074143	35828922	36091114	16265703
itaconic acid_13C1	4077179	2840393	1905966	2830376	4240572	2060082	5199162	3307861	2416452	6514322	8075965	2600217	6581899	3403743	3590619	7579286	8863662	2848058	29231614	6118756	5283736	41306593	115341498	19086285	46984442	31280632	8258429	55354169	103337289	6691077	70723	1843294	1684955	2604831	994796	602703	2622064	7257066	5443215	2076691	1157656	2480193	7347317	4426820	2006511	966063	2182571	2945707	4618251	1209735	396356	2345880	3421286	4806288	1371405
itaconic acid_13C2	0	0	0	0	0	0	0	0	0	1039107	1479323	0	493410	0	0	1353486	1531116	0	3694862	0	0	11945028	35140261	1150331	8761449	5465701	377810	15842769	30551708	1033890	0	0	0	0	0	0	0	0	424821	0	0	0	698357	0	0	0	0	360516	798605	0	0	0	469331	743150	0
lactate	7445075382	6316711995	6353775917	5932158178	6229072155	2641956834	4864947976	3100417007	3754061323	3069983887	3837000083	4813265294	6028192424	5099729528	5596354201	5370938001	6168341539	3751599941	2052084643	2223224943	1451443407	1795043682	852779103	2751728705	1901200978	2446365092	2359853615	3064114655	2697441118	2534312001	5926059372	6249884760	5753346199	5495091686	4919393976	6310555108	5835228455	2717017465	6178675085	3486284489	2281187981	6376326332	2401033696	5046210987	5170815738	2411975999	2730275679	2756608378	2394883732	2650927556	2388192977	13415636677	2460311925	5965454170	2995308253
lactate_13C1	270744488	229529625	231711787	217745049	227242474	94040176	180646477	113359846	118419910	115399674	182831342	177090119	227661449	186299386	203662814	199181345	224848995	140196328	77175591	81782143	53620302	65246321	32345100	99849450	73342154	93300955	90531538	110124194	102483354	97326140	217628748	229556599	206673190	200957782	183386834	221533174	213880160	128352613	221925420	130969556	91886050	229594789	97932363	181510137	185008416	81122901	100833939	99275890	90005950	102601982	90842327	475515196	95153177	213659389	102214067
lactate_13C2	5195435	4512272	3869598	4099617	4374403	2482579	4551545	2664345	10642861	5671530	9256070	8972538	8518587	7564556	20691366	14257950	23994721	16274418	5703945	4753786	5879619	8461582	8708966	11149390	14064715	6459906	32215324	19046412	28503992	30825039	7258418	6387452	5537404	5894294	5287144	19387726	11048929	11583385	16307696	8366993	9162880	23402036	27638019	15598531	13911417	3388935	16560977	19250414	10564545	10667152	10085616	26595535	25690298	28936853	5355612
lactate_13C3	30539719	28697360	29617252	28391556	29639579	12045680	55365345	27017581	217395937	94325740	161519509	164171206	179325890	131482969	447772007	333563212	570894335	432364639	186891187	168541102	185646372	215522986	191593234	249989025	284882216	153722567	792860264	466346653	709574260	745961864	111175405	88551974	74120712	85996432	72223988	569551344	336633718	256483313	355217395	153943249	186149004	543663488	493193136	550044321	328019194	116274841	235599595	322337432	232583642	225327385	194440599	609505862	590478631	695852743	204371504
leucine / leucine(iso)	430855064	536966846	141512269	510921533	473878414	105875095	300685419	211999005	361067179	156124401	672189796	285579098	504153422	522977298	411396064	465356879	1157148632	487107273	600121773	694927202	414636747	313230041	435565287	977577658	821932448	1858985761	1157983449	1153497356	1100710049	794865082	186942015	413715894	288922849	392567744	266385912	5363495370	1655962116	1833622480	2768540408	1764336038	1417884310	1883873526	1826699960	1884017989	1629426049	853525040	1493657233	1184917690	1615936244	1165878752	960262637	3454240009	901848425	1923754159	708528077
leucine / leucine(iso)_13C1	21657887	33389908	30128313	34870115	32691262	6483032	19436880	24047732	21054863	12102699	43709136	30950551	32588325	34072200	27323878	29499843	81191655	37419350	41596929	46792720	18459090	21224884	29631900	66111658	55968466	125869690	78259010	78301130	74182970	53975570	22657086	16100445	27185138	25708250	17508422	362907823	110498859	123089990	170479131	120941767	93437565	125267090	122195203	128702124	107621419	59228940	100111037	81249680	109195838	76536933	64281077	229017972	63101960	126631814	48402939
leucine / leucine(iso)_13C2	584921	655554	496736	501811	600673	380561	419805	429952	711422	695137	882436	479145	659620	593032	495651	547315	1393775	652852	1069204	1109124	592735	794936	743212	1498948	1279963	2362068	1742162	1679255	1472073	1270973	493320	483998	558458	386284	446968	7540736	2045182	2609068	3807005	2569252	2048101	2619585	2608233	2922086	2245430	1297511	2259006	1819491	2466572	1537566	1557624	4781844	1291812	2494417	1114607
leucine / leucine(iso)_13C3	0	7825	7300	0	7785	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
leucine / leucine(iso)_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
malate	19907237	16361587	24729273	13543284	19396511	27066208	13921871	9141469	16000845	9845049	11273208	19835798	19023465	14669817	36483504	17594180	22129339	32096611	26718081	21634839	22383178	15674379	19759031	24788066	28106229	32968204	38068283	24274158	34350881	42696129	5021562	15479527	20397457	14337576	8354155	5401425	22785920	24891131	17292390	9990979	7291762	33095074	38377211	29564158	22731426	7925918	30827330	45439229	29545708	23825162	12554519	42052564	62001586	55490338	24214669
malate_13C1	815793	250655	756440	333139	452021	732492	406791	323371	449967	379361	703374	582548	574320	386217	1109857	1079448	1156647	970555	884767	588938	593325	716434	939574	528709	1033723	1286172	1226982	1396360	1910424	1647970	0	322339	544005	208972	0	104132	659037	767262	791227	200653	129732	998697	1376832	1398249	887426	145811	1018493	1471415	1033673	647297	607314	1629270	2041889	2334768	776024
malate_13C2	0	0	0	0	0	0	0	0	0	600356	534901	0	517690	149293	230849	1645697	1168185	185374	496316	0	0	338679	590434	48681	287399	468586	81057	809038	1223642	89258	0	0	0	0	0	0	0	0	351068	0	68932	297071	375068	645618	242907	0	0	0	61871	0	87272	325925	833046	955419	0
malate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	487752	145628	99926	90318	0	0	0	0	0	82926	0	55635	516419	127368	441056	650478	0	0	0	0	0	0	0	0	0	0	0	77288	320067	243164	0	0	0	67217	0	0	0	153112	612803	509599	0
malate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
mevalonate_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
N-acetyl-glucosamine-1/6-phosphate	0	0	71837	0	0	55404	38584	37216	89207	70094	13183	0	0	7104	44453	0	0	40922	0	19234	0	20996	79397	44257	11664	103483	16981	9171	8400	0	0	11255	12032	11555	0	0	65210	28867	220940	46290	65167	112061	100002	49035	0	84185	47973	128136	136495	47058	11551	58047	13592	32512	102186
N-acetyl-glucosamine-1/6-phosphate_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	12537	12070	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
N-acetyl-glucosamine-1/6-phosphate_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8883	0	0	0	0	0	0	0	0	8413	0	0	0	0	0	0	0
NAD+	0	0	0	0	0	0	0	86011	0	0	0	0	0	0	0	0	0	0	0	0	0	0	98032	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	102722	0	77789	0	0	0	0	89983	0	0
NADH	0	0	0	0	0	0	0	0	0	0	0	63610	0	0	0	0	0	0	0	0	0	0	0	48257	0	43670	0	0	0	57634	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	61871	0	0	0	0	49377	0	0	0
NADP+	5473558	5224494	5205224	5228660	4883373	4166623	2637836	2395845	4103659	2043654	5334193	5122246	3358494	5717637	7553385	3080782	6522572	6231056	2110756	4025075	3687526	1792601	4538692	3615042	4507785	2478588	3715113	2839335	6172824	4515652	5061060	5943985	4469027	4753585	4585418	2699335	2056582	2003134	2487015	1693080	5470826	7306192	6340536	6828708	6024033	2991365	5585325	4413000	4951839	4822506	3333900	4429111	1933471	4899055	3956383
NADPH	2430628	1823252	0	326298	1856951	1467269	304487	551874	52425	195329	0	534232	1817547	2860602	1255754	623370	2854876	1823577	1108904	355190	467190	205522	1155345	0	678524	147308	0	1258737	32321	83983	0	453151	1085249	1414433	246803	1560728	28790	0	0	0	547953	18105	29131	23306	484951	805082	29205	17623	0	65011	520107	0	0	23115	0
N-carbamoyl-L-aspartate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
N-carbamoyl-L-aspartate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
N-carbamoyl-L-aspartate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	112824	0	0
N-carbamoyl-L-aspartate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
N-carbamoyl-L-aspartate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
N-carbamoyl-L-aspartate_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
oxaloacetate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
oxaloacetate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
oxaloacetate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
oxaloacetate_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
oxaloacetate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
phosphoenolpyruvate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	19684	0	0	0	0	14924	348083	0	0	21357	0	0	0	0	0	0	0	0	0	0	0	0	27477	0	23177	17201	0	0	0	0	0	0	102257	0	15075	0
phosphoenolpyruvate_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
phosphoenolpyruvate_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9733	0	0	9308	0	0	0	9194	0	0	0	12247	0	0	8925	9204	0	0	0	9633	0	0	0	7575	11418	0	0	11507	0
phosphoenolpyruvate_13C3	0	0	0	0	0	0	0	0	0	0	19196	0	0	0	0	0	0	0	0	16302	0	0	0	60492	13112	17997	159391	0	141654	115832	0	0	0	0	0	0	0	0	0	0	52217	91830	145783	169774	11211	28034	26911	29362	51460	0	29356	216424	25703	111886	33021
PRPP	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5776	0	0	0	0	0	0	5508	0	0	0	0	0	0	0	0	4216	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
PRPP_13C1	0	0	0	0	0	0	0	0	0	0	0	5288	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5364	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
PRPP_13C2	0	6676	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5038	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
PRPP_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
PRPP_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5031	0	0	0	0	0	0	0	4823	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5482	0	0	0
PRPP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5534	0	0	0	7866	0	0	0	0	4837	0	4881	0
pyruvate	65512311	247966659	37119543	37969711	26982150	19033522	10509302	29877454	24418594	19053238	21588204	20641303	14578861	24353301	15992246	23500927	15451495	22442262	20916177	20365689	22886247	17820885	20307542	85062698	22423328	145104569	33777671	87880822	56181503	22693317	19643531	43964115	55761187	19488887	23577755	554451500	53308940	43090348	47364454	58541209	34138556	33698920	24498701	78288390	46903659	17335566	15843703	26974304	14700209	13325480	13200977	792317753	12896282	110663476	23855902
pyruvate_13C1	1461456	6955168	1008399	1053556	793529	461003	290258	801571	776512	592878	634040	625701	193816	690612	392270	741416	521685	618098	583675	529266	980352	567630	740134	2345681	646667	3860449	972646	2419167	1600878	743247	716438	1240264	1457848	726434	608567	16766762	1600924	1214473	1588210	1551034	1108179	1023068	751736	2383508	1434910	586319	749565	880690	458479	372381	553713	25208331	374013	3183297	714882
pyruvate_13C2	0	0	0	0	0	0	0	322644	0	130765	0	0	57494	0	0	124403	0	0	196990	0	0	0	0	0	0	96411	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	730418	0	0	0	0	0	0	0
pyruvate_13C3	0	0	0	0	0	0	0	0	1460821	592200	636877	582033	428695	613182	698555	854290	530030	990811	626263	1004289	653561	1229177	902105	1390344	2785793	1374009	8176420	3414918	4236534	3769649	0	0	0	0	0	1472681	2626041	3576715	5427512	1577508	6495816	7399211	8775176	9921142	3148071	3211359	4362796	3988625	4656779	2715602	4414705	5477776	6997994	9025160	3132596
S-adenosyl-L-homoCysteine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
S-adenosyl-L-homoCysteine_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
S-adenosyl-L-methionine	17890523	12966001	16325900	15912419	22318161	20790870	7306027	5056866	11792760	7308894	14595915	15075284	8954776	11146346	23105427	8435301	23899766	17760799	11612339	11981294	14780187	7562771	24822168	16280464	19819813	6647848	17078011	18745555	23788859	17246111	9638548	15171563	14211197	17975926	11344383	6891475	15994794	12892943	15316876	10250781	11558772	16641096	14275814	17415057	12004115	11955083	19240450	14952960	18618486	14835974	14639669	15572321	6677547	19982946	12339757
S-adenosyl-L-methionine_13C1	2819679	2011097	2412172	2334047	3294830	3143112	1143999	824872	1759418	1140773	2265855	2277954	1363555	1656658	3459878	1241507	3647607	2745525	1826726	1878659	2137092	1110820	3641031	2467052	2915405	996967	2675246	2872959	3699184	2485809	1484536	2313608	2192825	2852925	1733368	1030147	2503962	1971094	2322875	1614107	1642593	2513429	2221981	2678626	1752015	1798297	2949627	2244210	2789348	2127479	2329041	2388836	1031814	3129542	1804155
S-adenosyl-L-methionine_13C2	123141	30142	104000	127939	141286	158541	7615	30706	81597	27707	67650	85394	11036	83103	203267	16332	226705	114814	62072	92388	112475	17664	256938	134379	240944	8846	160372	154332	168173	141663	36511	76985	64668	122178	25792	12286	90579	55790	136197	59790	49723	83529	114072	135227	63754	88157	195367	111452	173893	66128	142679	217054	48129	185388	62992
S-adenosyl-L-methionine_13C3	0	7879	0	0	0	0	0	0	0	0	0	0	0	0	10280	0	0	7596	7816	0	0	6639	0	6738	35566	0	64911	22166	24780	32226	0	0	0	0	0	0	0	7746	0	0	8516	8958	0	7168	0	6921	12302	11853	8648	0	9252	55488	16226	32759	10294
S-adenosyl-L-methionine_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	18840	0	16438	0	17774	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8014	0	0	7398	0	21621	8234	0	17002	0
S-adenosyl-L-methionine_13C5	0	0	0	0	0	0	0	0	9391	0	0	0	0	19618	74784	0	33594	26597	11634	7921	104885	31691	120653	46666	228518	25560	430713	301641	339049	387237	0	0	0	0	0	0	19027	10241	11595	0	91370	64186	27713	94488	21846	88198	279354	107694	192404	0	509856	523702	245134	580895	105990
S-adenosyl-L-methionine_13C6	0	9484	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7114	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	32656	6455	7482	0
S-adenosyl-L-methionine_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
S-adenosyl-L-methionine_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8533	0	0	0	0	4636	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
S-adenosyl-L-methionine_13C9	61273	36228	66351	111870	77095	62066	24427	39056	42550	27219	69847	83659	24434	36739	85133	37652	86748	94328	31478	92289	73842	22275	20706	67582	93743	53898	26752	110493	21614	59752	86221	116310	127229	116035	101186	76386	93575	125823	22144	79432	76092	36982	46753	27946	50470	52696	34039	32347	2569	23596	29691	51657	10974	30676	60751
serine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	149319	0	581649	1052151	73226	0	81362	1086941	125167	0	0	0	0	0	0	1353422	431180	151071	158850	0	87275	560270	735519	1096996	186483	0	399795	77166	303518	0	191412	1370906	70254	866162	69197
serine_13C1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
serine_13C2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
serine_13C3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
sorbitol / galactitol / L-iditol / manitol	25797264	26487783	28732464	26044994	27302100	10249910	15929364	9860069	17578763	9579511	16965247	20266547	38289584	17043022	52328950	41668382	106383821	17106788	12778251	13954104	7971403	9295243	13325513	12203275	11768523	21197288	15688590	12507379	7673346	13313494	35643460	45192445	23362993	35348478	12238212	124542593	59930607	6794527	29662818	12179282	23036449	80228569	20344567	39540814	118990567	7716642	22771905	12472505	15042774	22668123	10555890	135073488	12708768	56182953	17468689
sorbitol / galactitol / L-iditol / manitol_13C6	0	0	0	0	0	0	0	0	114414	0	41286	59725	0	0	506405	159222	30353	255003	0	18528	18746	0	0	21067	26409	30938	545522	71937	69061	521227	0	0	0	0	0	0	388182	0	0	0	0	689452	68599	266581	45930	18312	29579	145210	0	25999	0	2001178	673683	1127566	105543
succinate	5910751	5281259	15435727	7016072	15488012	10048701	7565027	6686974	10446671	7833344	10103355	9433833	17102046	5382349	26914113	11978891	18100359	16972061	29260514	1294053	7807948	13358946	22689421	23950781	7267611	12217530	24023012	3020500	17028909	15661371	2315807	7153672	11334253	6820073	3616074	9325534	6972250	14117217	6916898	5001484	3542556	9858134	20734466	13224809	5588193	2908444	8668710	14461384	6524595	5585955	1490001	15091035	21319838	11128904	3007098
succinate_13C1	766944	566341	892291	668437	938299	798433	371856	640797	840929	470438	1173408	577954	551707	524905	1304840	1829484	2237462	963239	582310	923327	967791	1293242	2456235	1136173	1079134	326658	1068459	1143869	1358639	1049068	185344	783306	454389	907220	114480	535751	1124724	1182793	962874	550073	342025	792960	1381985	1015520	527885	441781	886196	789478	610300	270126	145475	1006122	853193	577219	325847
succinate_13C2	0	0	0	0	0	0	0	0	0	1016796	1059391	0	394844	0	0	1221372	1586124	0	324711	89409	0	459069	1158291	0	54415	36158	58214	362261	1019497	0	0	0	0	0	0	0	158041	124032	588886	0	0	212705	222532	296135	51049	0	59583	53558	70575	54958	0	212194	364398	264788	52289
succinate_13C3	0	0	0	0	0	0	0	0	0	92572	195963	0	40877	0	65499	349314	217149	0	0	0	0	53485	168174	0	0	0	0	105791	201658	119374	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	62152	101316	0	0
succinate_13C4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	130569	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	51462	0	51405	0	0	35031	0	0	48903	0	0	0	0	42264
thiamine diphosphate+	7638270	5999659	6555920	7061622	9734314	7547522	2662286	2137661	4406542	3041585	6432849	6435959	3378927	4691243	7885161	2992329	8996976	6592445	2746248	3597621	4840405	2493147	7300963	4600615	5265290	1964958	5858663	6622717	8616316	5874488	4046711	5951960	5934380	7409820	4212155	3100475	5378753	5290152	6822707	3397686	4177635	6172037	6066579	6923125	4135276	3279332	6212090	5852970	6328917	4276909	4017788	5384797	1984761	6377624	3844856
thiamine phosphate+	156966	88717	200897	214067	448814	121980	7774	7295	31116	13528	140012	93340	0	45014	150805	16119	219866	148312	21691	39507	78173	5736	110932	113893	58854	8641	204697	120183	295007	162554	62432	118939	143880	175080	27553	0	3027211	2250031	1927064	1096520	504770	1496303	1608930	1427677	507896	480864	1405912	1338278	1920712	473820	405937	671208	1006464	2457724	419522
thiamine+	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	486380	0	0	0
UDP-N-acetyl-galactosamine/glucosamine	109677	50822	0	62081	109138	127435	639856	423742	0	280030	44009	0	586112	279113	49386	276850	153223	64834	618437	470173	0	398741	179985	165070	240406	753248	62278	94003	52370	111322	74352	78195	53270	1296	189263	180458	115406	255294	206572	75608	95665	254026	253950	140887	196175	191129	117533	523452	340044	309207	131802	294225	576711	314255	257380
UDP-N-acetyl-galactosamine/glucosamine_13C13	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
UDP-N-acetyl-galactosamine/glucosamine_13C6	0	0	0	0	0	0	0	0	0	0	0	0	9972	0	0	9223	0	0	0	0	0	0	0	0	0	0	4215	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2542	0	0	1348	0	4882	0
UDP-N-acetyl-galactosamine/glucosamine_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9673	0	0	0	0	0
UMP	0	0	0	0	0	0	0	0	0	39779	0	0	52555	0	0	45843	0	0	0	36006	48914	38348	0	0	0	0	0	0	0	0	0	0	0	0	0	53747	1063870	1204395	1430153	659268	0	430568	368335	554412	109864	49168	55469	338614	185678	0	122272	0	1662249	780741	0
UMP_13C5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
UMP_13C6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
UMP_13C7	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
UMP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	41820	0	0
UMP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	15551	0	0	12316	0	0	0	0	0	0	0	10880
UTP	38387633	38939282	15733993	17315050	23747504	19030748	18045376	19046991	15846295	9530182	20835348	23743731	29400515	59445906	38703404	14434932	39703175	30938631	11895188	21862925	16954080	6602919	23805378	14934384	37137427	13959334	28296476	24523183	30747443	23563574	45307856	32122285	26661838	32781195	36500415	37915469	39142734	29349286	41069316	42665336	51441948	37285856	30611649	31587282	37591120	21930169	19473014	19580899	19312815	22843915	41957997	29132426	11917291	32161148	24088352
UTP_13C5	0	0	0	0	0	0	0	0	0	0	0	6467	0	0	65057	9181	106242	61937	0	0	54905	0	116131	59380	35406	0	349592	239860	418423	315885	0	0	0	0	0	0	22014	29050	15064	0	0	55798	67198	58719	0	14162	106864	109029	113184	6252	133004	286781	121737	450420	33407
UTP_13C6	8180	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6369	0	0	0	0	11591	13967	0	0	0	8551	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6598	0
UTP_13C7	0	0	0	0	0	5560	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	8369	0
UTP_13C8	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5833	0	0	0	0	0
UTP_13C9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	4261	0	0	0	0	0	0	0	0	4844	0	0	0	0
xylitol / arabitol / ribito	86261758	53267044	37004411	37771212	34766248	2491554	11727536	16133347	21037245	21647289	20520377	15400304	9544869	19990753	16172188	11306711	19448949	20697602	12152159	21933489	8831514	16962378	16519508	14072115	19124595	17783501	16786310	14481123	22175229	16180498	11351176	11614847	14754956	11746391	11534112	28856751	8085244	15664874	11781639	9257339	4224621	6043990	7902834	5241559	3475629	2304717	4540003	7801969	5940190	5998480	3868679	5127323	7377079	5670801	3259489
xylitol / arabitol / ribito_13C5	0	0	0	0	0	0	0	0	36346	0	0	0	0	0	0	25851	0	171492	17932	0	186435	90679	176470	263590	98461	53490	638262	318270	463365	591688	0	0	0	0	0	0	51885	157759	0	0	0	25395	314030	46375	0	11336	200756	210608	222555	14359	13060	55861	687380	340782	15116
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	KEGG ID
1,3-diphosphoglycerate	C00236
1,3-diphosphoglycerate_13C1
1,3-diphosphoglycerate_13C2
1,3-diphosphoglycerate_13C3
2,3-diphosphoglycerate	C01159
2,3-diphosphoglycerate_13C1
2,3-diphosphoglycerate_13C2
2,3-diphosphoglycerate_13C3
2/3-phosphoglycerate	C00631 / C00197
2/3-phosphoglycerate_13C1
2/3-phosphoglycerate_13C2
2/3-phosphoglycerate_13C3
2-HG	C02630
2-HG_13C1
2-HG_13C2
2-HG_13C3
2-HG_13C4
2-HG_13C5
3-phospho-serine	C01005
3-phospho-serine_13C1
3-phospho-serine_13C2
3-phospho-serine_13C3
6-phospho-D-gluconate	C00345
6-phospho-D-gluconate_13C1
6-phospho-D-gluconate_13C2
6-phospho-D-gluconate_13C3
6-phospho-D-gluconate_13C4
6-phospho-D-gluconate_13C5
6-phospho-D-gluconate_13C6
acetoacetate / succinic semialdehyde	C00164 / C00232
acetoacetate / succinic semialdehyde_13C1
acetoacetate / succinic semialdehyde_13C2
acetoacetate / succinic semialdehyde_13C3
acetoacetate / succinic semialdehyde_13C4
acetyl-CoA +	C00024
acetyl-CoA_13C1 +
acetyl-CoA_13C2 +
aconitic acid -	C6H6O6
aconitic acid_13C1 -
aconitic acid_13C2 -
adenosine	C00212
adenosine_13C10
adenosine_13C5
adenosine_13C6
adenosine_13C7
adenosine_13C8
adenosine_13C9
ADP / dGDP	C00008 / C00361
ADP / dGDP_13C1
ADP / dGDP_13C10
ADP / dGDP_13C2
ADP / dGDP_13C3
ADP / dGDP_13C4
ADP / dGDP_13C5
ADP / dGDP_13C6
ADP / dGDP_13C7
ADP / dGDP_13C8
ADP / dGDP_13C9
AICAR	C04677
AICAR_13C5
AICAR_13C6
AICAR_13C7
AICAR_13C8
AICAR_13C9
a-KG	C00026
a-KG_13C1
a-KG_13C2
a-KG_13C3
a-KG_13C4
a-KG_13C5
alanine	C00041-C00133
alanine_13C1
alanine_13C2
alanine_13C3
AMP / dGMP	C00020 / C00362
AMP / dGMP_13C1
AMP / dGMP_13C10
AMP / dGMP_13C2
AMP / dGMP_13C5
AMP / dGMP_13C6
AMP / dGMP_13C7
AMP / dGMP_13C8
AMP / dGMP_13C9
aspartate	C16433-C00049
aspartate_13C1
aspartate_13C2
aspartate_13C3
aspartate_13C4
ATP / dGTP	C00002 / C00286
ATP / dGTP_13C10
ATP / dGTP_13C5
ATP / dGTP_13C6
ATP / dGTP_13C7
ATP / dGTP_13C8
ATP / dGTP_13C9
choline+	C00114
choline_13C1+
choline_13C2+
choline_13C3+
choline_13C4+
choline_13C5+
citrate(iso)/citrate	C00311 / C00063
citrate(iso)/citrate_13C1
citrate(iso)/citrate_13C2
citrate(iso)/citrate_13C3
citrate(iso)/citrate_13C4
citrate(iso)/citrate_13C5
citrate(iso)/citrate_13C6
CMP	C00055
CMP_13C5
CMP_13C6
CMP_13C7
CMP_13C8
CMP_13C9
Crotonyl-CoA	C00877
CTP	C00063
CTP_13C5
CTP_13C6
CTP_13C7
CTP_13C8
CTP_13C9
cystathionine	C00542
cystathionine_13C1
cysteine	C00736-C00097
cysteine_13C1
cysteine_13C2
cysteine_13C3
dATP	C00131
dATP_13C10
dATP_13C5
dATP_13C6
dATP_13C7
dATP_13C8
dATP_13C9
dCTP	C00458
dCTP_13C5
dCTP_13C6
dCTP_13C7
dCTP_13C8
dCTP_13C9
deoxyguanosine	C00330
deoxyguanosine_13C10
deoxyguanosine_13C5
deoxyguanosine_13C6
deoxyguanosine_13C7
deoxyguanosine_13C8
deoxyguanosine_13C9
D-galactosamine/glucosamine-1/6-phosphate	C03783 / C00352 / C06156 / C00352
D-galactosamine/glucosamine-1/6-phosphate_13C6
D-ribose-1/5-phosphate	C00620 / C00117
D-ribose-1/5-phosphate_13C1
D-ribose-1/5-phosphate_13C2
D-ribose-1/5-phosphate_13C3
D-ribose-1/5-phosphate_13C4
D-ribose-1/5-phosphate_13C5
D-sedoheptulose-7-phosphate	C05382
D-sedoheptulose-7-phosphate_13C1
D-sedoheptulose-7-phosphate_13C2
D-sedoheptulose-7-phosphate_13C3
D-sedoheptulose-7-phosphate_13C4
D-sedoheptulose-7-phosphate_13C5
D-sedoheptulose-7-phosphate_13C6
D-sedoheptulose-7-phosphate_13C7
dTTP	C00459
dTTP_13C10
dTTP_13C5
dTTP_13C6
dTTP_13C7
dTTP_13C8
dTTP_13C9
dUTP	C00460
dUTP_13C5
dUTP_13C6
dUTP_13C7
dUTP_13C8
dUTP_13C9
F-1,6/2,6-P	C00354 / C00665
F-1,6/2,6-P_13C1
F-1,6/2,6-P_13C2
F-1,6/2,6-P_13C3
F-1,6/2,6-P_13C4
F-1,6/2,6-P_13C5
F-1,6/2,6-P_13C6
F6P/G1P/G6P	C00085 / C00103 / C00092
F6P/G1P/G6P_13C1
F6P/G1P/G6P_13C2
F6P/G1P/G6P_13C3
F6P/G1P/G6P_13C4
F6P/G1P/G6P_13C5
F6P/G1P/G6P_13C6
fructose / mannose	C00095 / C00159
fumarate	C00122
fumarate_13C1
fumarate_13C2
fumarate_13C3
fumarate_13C4
galactose / glucose	C00124 / C00267
glucose_13C6
GAP / DHAP	C00118 / C00111
GAP / DHAP_13C1
GAP / DHAP_13C2
GAP / DHAP_13C3
glutamate	C00302-C00025
glutamate_13C1
glutamate_13C2
glutamate_13C3
glutamate_13C4
glutamate_13C5
glutamine	C00303-C00064
glutamine_13C1
glutamine_13C2
glutamine_13C3
glutamine_13C4
glutamine_13C5
glutathione	C00051
glutathione_13C1
glutathione_13C2
glutathione_13C3
glutathione_13C4
glutathione_13C5
glutathione disulfide	C00127
glutathione disulfide_13C1
glutathione disulfide_13C2
glutathione disulfide_13C3
glutathione disulfide_13C4
glutathione disulfide_13C5
glycerate	C00258
glycerate_13C1
glycerate_13C2
glycerate_13C3
glycerol-2/3-phosphate	C02979 / C00093
glycerol-2/3-phosphate_13C2
glycerol-2/3-phosphate_13C3
glycine	C00037
glycine_13C1
glycine_13C2
GMP	C00144
GMP_13C10
GMP_13C5
GMP_13C6
GMP_13C7
GMP_13C8
GMP_13C9
GTP	C00044
GTP_13C10
GTP_13C5
GTP_13C6
GTP_13C7
GTP_13C8
GTP_13C9
guanosine	C00387
guanosine_13C10
guanosine_13C5
guanosine_13C6
guanosine_13C7
guanosine_13C8
guanosine_13C9
IDP	C00104
IDP_13C10
IDP_13C5
IDP_13C6
IDP_13C7
IDP_13C8
IDP_13C9
IMP	C00130
IMP_13C10
IMP_13C5
IMP_13C6
IMP_13C7
IMP_13C8
IMP_13C9
itaconic acid	C00490
itaconic acid_13C1
itaconic acid_13C2
lactate	C01432-C00186
lactate_13C1
lactate_13C2
lactate_13C3
leucine / leucine(iso)	C16439-C00123 / C16434-C00407
leucine / leucine(iso)_13C1
leucine / leucine(iso)_13C2
leucine / leucine(iso)_13C3
leucine / leucine(iso)_13C6
malate	C00711-C00149
malate_13C1
malate_13C2
malate_13C3
malate_13C4
mevalonate	C00418
mevalonate_13C1
mevalonate_13C2
mevalonate_13C3
mevalonate_13C4
mevalonate_13C5
mevalonate_13C6
N-acetyl-glucosamine-1/6-phosphate	C04256 / C00357
N-acetyl-glucosamine-1/6-phosphate_13C6
N-acetyl-glucosamine-1/6-phosphate_13C8
NAD+	C00003
NADH	C00004
NADP+	C00006
NADPH	C00005
N-carbamoyl-L-aspartate	C00438
N-carbamoyl-L-aspartate_13C1
N-carbamoyl-L-aspartate_13C2
N-carbamoyl-L-aspartate_13C3
N-carbamoyl-L-aspartate_13C4
N-carbamoyl-L-aspartate_13C5
oxaloacetate	C00036
oxaloacetate_13C1
oxaloacetate_13C2
oxaloacetate_13C3
oxaloacetate_13C4
phosphoenolpyruvate	C00074
phosphoenolpyruvate_13C1
phosphoenolpyruvate_13C2
phosphoenolpyruvate_13C3
PRPP	C00119
PRPP_13C1
PRPP_13C2
PRPP_13C3
PRPP_13C4
PRPP_13C5
pyruvate	C00022
pyruvate_13C1
pyruvate_13C2
pyruvate_13C3
S-adenosyl-L-homoCysteine	C00021
S-adenosyl-L-homoCysteine_13C1
S-adenosyl-L-methionine	C00019
S-adenosyl-L-methionine_13C1
S-adenosyl-L-methionine_13C2
S-adenosyl-L-methionine_13C3
S-adenosyl-L-methionine_13C4
S-adenosyl-L-methionine_13C5
S-adenosyl-L-methionine_13C6
S-adenosyl-L-methionine_13C7
S-adenosyl-L-methionine_13C8
S-adenosyl-L-methionine_13C9
serine	C00716-C00065
serine_13C1
serine_13C2
serine_13C3
sorbitol / galactitol / L-iditol / manitol	C00794 / C01697 / C01507 / C00392
sorbitol / galactitol / L-iditol / manitol_13C6
succinate	C00042
succinate_13C1
succinate_13C2
succinate_13C3
succinate_13C4
thiamine diphosphate+	C00068
thiamine phosphate+	C01081
thiamine+	C00378
UDP-N-acetyl-galactosamine/glucosamine	C00203 / C00043
UDP-N-acetyl-galactosamine/glucosamine_13C13
UDP-N-acetyl-galactosamine/glucosamine_13C6
UDP-N-acetyl-galactosamine/glucosamine_13C8
UMP	C00105
UMP_13C5
UMP_13C6
UMP_13C7
UMP_13C8
UMP_13C9
UTP	C00075
UTP_13C5
UTP_13C6
UTP_13C7
UTP_13C8
UTP_13C9
xylitol / arabitol / ribito	C00379/ C01904 / C00532 / C00474
xylitol / arabitol / ribito_13C5
METABOLITES_END
#END