#METABOLOMICS WORKBENCH pbjonker_20250208_161132 DATATRACK_ID:5609 STUDY_ID:ST003716 ANALYSIS_ID:AN006097 PROJECT_ID:PR002307 VERSION 1 CREATED_ON February 12, 2025, 7:12 pm #PROJECT PR:PROJECT_TITLE Microenvironmental arginine restriction sensitizes pancreatic cancers to PR:PROJECT_TITLE polyunsaturated fatty acids by suppression of lipid synthesis PR:PROJECT_TYPE Lipidomics PR:PROJECT_SUMMARY Nutrient limitation is a characteristic feature of poorly perfused tumors. These PR:PROJECT_SUMMARY changes in nutrient availability impose metabolic constraints and perturb PR:PROJECT_SUMMARY metabolic pathways in cancer cells, in contrast to cells in well-perfused PR:PROJECT_SUMMARY tissues. Consequently, targeting the metabolic dependencies created by tumor PR:PROJECT_SUMMARY microenvironmental constraints may be a promising antineoplastic therapeutic PR:PROJECT_SUMMARY approach. To identify these adaptations, we challenged pancreatic cancer cell PR:PROJECT_SUMMARY lines (mouse Pancreatic Ductal Adenocarcinoma - PDAC) with pathophysiological PR:PROJECT_SUMMARY nutrient levels and analyzed changes to cell metabolism. Here, we report that PR:PROJECT_SUMMARY arginine limitation in pancreatic cancer perturbs saturated and monounsaturated PR:PROJECT_SUMMARY fatty acid synthesis by suppressing the lipogenic transcription factor SREBP1. PR:PROJECT_SUMMARY Synthesis of these acyl species is critical to maintaining a balance of PR:PROJECT_SUMMARY saturated, monounsaturated, and polyunsaturated fatty acids in cellular PR:PROJECT_SUMMARY membranes. We found that, as a consequence of the loss of fatty acid synthesis, PR:PROJECT_SUMMARY pancreatic cancer cells were unable to maintain balanced lipidomes when exposed PR:PROJECT_SUMMARY to polyunsaturated fatty acids, leading to cell death by ferroptosis. PR:PROJECT_SUMMARY Importantly, we found orally administering oils rich in polyunsaturated fats PR:PROJECT_SUMMARY reduces tumor burden in mice with pancreatic cancer. In sum, this study PR:PROJECT_SUMMARY illustrates that arginine restriction in the tumor microenvironment alters PR:PROJECT_SUMMARY pancreatic cancer cells by perturbing lipid synthesis, making them sensitive to PR:PROJECT_SUMMARY supplementation with polyunsaturated fats. PR:INSTITUTE University of Chicago PR:LAST_NAME Jonker PR:FIRST_NAME Patrick PR:ADDRESS 929 E 57th St. Chicago IL, 60637 PR:EMAIL pbjonker@uchicago.edu PR:PHONE 6162884547 #STUDY ST:STUDY_TITLE Lipidomics analysis of mice treated with tung or safflower oil by oral gavage. ST:STUDY_TYPE Lipidomics ST:STUDY_SUMMARY Lyz2(-/-)-Cre;Arg1(fl/fl) or Lyz2(+/+)-Cre;Arg1(fl/fl) mice were injected with ST:STUDY_SUMMARY orthotopic pancreatic cancer cell tumors and mice were gavaged with tung oil ST:STUDY_SUMMARY (PUFA high) or safflower oil (control) for 4 weeks. After treatment, tumors were ST:STUDY_SUMMARY dissected and sorted for pancreatic cancer cells and lipidomics was performed to ST:STUDY_SUMMARY determine how the lipidome of tumors changed. Lyz2(-/-)-Cre;Arg1(fl/fl) tumors ST:STUDY_SUMMARY are arginine deprived, while Lyz2(+/+)-Cre;Arg1(fl/fl) tumors have plasma levels ST:STUDY_SUMMARY of arginine, which allowed us to assay how arginine deprivation affects PUFA ST:STUDY_SUMMARY treatment in vivo. We found that arginine low tumors were more strongly affected ST:STUDY_SUMMARY by tung oil administration than tumors with plasma levels of arginine. This was ST:STUDY_SUMMARY reflected in the cellular peroxidation index of triglycerides in this dataset, ST:STUDY_SUMMARY which was calculated from this dataset. ST:INSTITUTE University of Chicago ST:DEPARTMENT Ben May Department of Cancer Research ST:LABORATORY Muir Lab ST:LAST_NAME Jonker ST:FIRST_NAME Patrick ST:ADDRESS 929 E 57th St. Chicago IL, 60637 ST:EMAIL pbjonker@uchicago.edu ST:PHONE 6162884547 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - S03_LysmCre-S_1 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S03_LysmCre-S_1.mzML SUBJECT_SAMPLE_FACTORS - S07_LysmCre-S_2 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S07_LysmCre-S_2.mzML SUBJECT_SAMPLE_FACTORS - S14_LysmCre-S_3 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S14_LysmCre-S_3.mzML SUBJECT_SAMPLE_FACTORS - S17_LysmCre-S_4 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S17_LysmCre-S_4.mzML SUBJECT_SAMPLE_FACTORS - S20_LysmCre-S_5 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S20_LysmCre-S_5.mzML SUBJECT_SAMPLE_FACTORS - S22_LysmCre-S_6 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S22_LysmCre-S_6.mzML SUBJECT_SAMPLE_FACTORS - S24_LysmCre-S_7 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S24_LysmCre-S_7.mzML SUBJECT_SAMPLE_FACTORS - S01_LysmCre-T_1 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S01_LysmCre-T_1.mzML SUBJECT_SAMPLE_FACTORS - S02_LysmCre-T_2 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S02_LysmCre-T_2.mzML SUBJECT_SAMPLE_FACTORS - S06_LysmCre-T_3 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S06_LysmCre-T_3.mzML SUBJECT_SAMPLE_FACTORS - S13_LysmCre-T_4 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S13_LysmCre-T_4.mzML SUBJECT_SAMPLE_FACTORS - S15_LysmCre-T_5 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S15_LysmCre-T_5.mzML SUBJECT_SAMPLE_FACTORS - S25_LysmCre-T_6 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S25_LysmCre-T_6.mzML SUBJECT_SAMPLE_FACTORS - S05_WT-S_1 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S05_WT-S_1.mzML SUBJECT_SAMPLE_FACTORS - S08_WT-S_2 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S08_WT-S_2.mzML SUBJECT_SAMPLE_FACTORS - S12_WT-S_3 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S12_WT-S_3.mzML SUBJECT_SAMPLE_FACTORS - S16_WT-S_4 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S16_WT-S_4.mzML SUBJECT_SAMPLE_FACTORS - S18_WT-S_5 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil RAW_FILE_NAME(Raw file name)=S18_WT-S_5.mzML SUBJECT_SAMPLE_FACTORS - S04_WT-T_1 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S04_WT-T_1.mzML SUBJECT_SAMPLE_FACTORS - S09_WT-T_2 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S09_WT-T_2.mzML SUBJECT_SAMPLE_FACTORS - S10_WT-T_3 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S10_WT-T_3.mzML SUBJECT_SAMPLE_FACTORS - S11_WT-T_4 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S11_WT-T_4.mzML SUBJECT_SAMPLE_FACTORS - S19_WT-T_5 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S19_WT-T_5.mzML SUBJECT_SAMPLE_FACTORS - S23_WT-T_6 Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil RAW_FILE_NAME(Raw file name)=S23_WT-T_6.mzML #COLLECTION CO:COLLECTION_SUMMARY Yellow fluorescent protein (YFP+) mPDAC3 cells were orthotopically implanted CO:COLLECTION_SUMMARY into C57BL/6 mice with Lyz2-Cre-/-;Argfl/fl or Lyz2-Cre+/+;Arg1fl/fl background. CO:COLLECTION_SUMMARY After treatment, tumors were removed and mechanically dissociated. 1mL of 1x PBS CO:COLLECTION_SUMMARY was added onto tumor and it was minced with a razor blade. Slurry was CO:COLLECTION_SUMMARY transferred to a 15mL conical tube with 3 mL 1x PBS. Enzyme master mix was added CO:COLLECTION_SUMMARY (Dispase 3 mg/mL; Collagenase 1 mg/mL; Liberase 0.1 mg/mL; DNase 0.1 mg/mL; CO:COLLECTION_SUMMARY Hyaluronidase (100 units). Once all tumors were processed they were rotated at CO:COLLECTION_SUMMARY 37C for 30 minutes. 110 uL 0.5M EDTA was then added to quench enzymatic CO:COLLECTION_SUMMARY reaction. Cells were then passed through 70 uM filter and sorted for YFP CO:COLLECTION_SUMMARY positive cancer cells on FACSAria Fusion 5-18 flow cytometer. CO:SAMPLE_TYPE Pancreatic cancer epithelial cells #TREATMENT TR:TREATMENT_SUMMARY Mice were orally gavaged once daily for 4 weeks with 80-130 uL tung oil or TR:TREATMENT_SUMMARY safflower oil depending on mouse weight - 1.67 uL/g. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY All samples, blanks, and QC sample pools were resuspended in 50µL of LC/MS SP:SAMPLEPREP_SUMMARY grade acetonitrile (A955, Fisher) and LC/MS grade isopropanol (A461, Fisher) SP:SAMPLEPREP_SUMMARY 50:50 (v/v), pulse vortexed, and sonicated for 5 min in a room temperature water SP:SAMPLEPREP_SUMMARY bath prior to LC-MS/MS analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY All samples, blanks, and QC sample pools were resuspended in 50µL of LC/MS CH:CHROMATOGRAPHY_SUMMARY grade acetonitrile (A955, Fisher) and LC/MS grade isopropanol (A461, Fisher) CH:CHROMATOGRAPHY_SUMMARY 50:50 (v/v), pulse vortexed, and sonicated for 5 min in a room temperature water CH:CHROMATOGRAPHY_SUMMARY bath prior to LC-MS/MS analysis. Samples were analyzed with a Vanquish dual pump CH:CHROMATOGRAPHY_SUMMARY liquid chromatography system coupled to an Orbitrap ID-X (Thermo Fisher CH:CHROMATOGRAPHY_SUMMARY Scientific) using a H-ESI source in both positive and negative mode. All samples CH:CHROMATOGRAPHY_SUMMARY were injected at 2 μL and lipids were separated with a reversed-phase CH:CHROMATOGRAPHY_SUMMARY chromatography using an Accucore C30 column (2.6 μm, 2.1mm × 150mm, CH:CHROMATOGRAPHY_SUMMARY 27826-152130, Thermo) combined with an Accucore guard cartridge (2.6 μm, 2.1 mm CH:CHROMATOGRAPHY_SUMMARY × 10 mm, 27826-012105, Thermo). Mobile phase A consisted of 60% LC/MS grade CH:CHROMATOGRAPHY_SUMMARY acetonitrile (A955, Fisher). Mobile phase B consisted of 90% LC/MS grade CH:CHROMATOGRAPHY_SUMMARY isopropanol (A461, Fisher) and 8% LC/MS grade acetonitrile. Both mobile phases CH:CHROMATOGRAPHY_SUMMARY contained 10mM ammonium formate (70221, Sigma) and 0.1% LC/MS grade formic acid CH:CHROMATOGRAPHY_SUMMARY (A11710X1-AMP, Fisher). Column temperature was kept at 50 °C, flow rate was CH:CHROMATOGRAPHY_SUMMARY held at 0.4 mL/min, and the chromatography gradient was as follows: 0-1 min held CH:CHROMATOGRAPHY_SUMMARY at 25% B,1-3 min from 25% B to 40% B, 3-19 min from 40% B to 75% B, 19-20.5 min CH:CHROMATOGRAPHY_SUMMARY from 75% B to 90% B, 20.5-28 min from 90% B to 95% B, 28-28.1 min from 95% B to CH:CHROMATOGRAPHY_SUMMARY 100% B, and 28.1-30 min held at 100% B. A 30 minute re-equilibration went as CH:CHROMATOGRAPHY_SUMMARY follows: 0-10 min held at 100% B and 0.2 mL/min, 10-15 min from 100% B to 50% B CH:CHROMATOGRAPHY_SUMMARY and held at 0.2 mL/min, 15-20 min held at 50% B and 0.2 mL/min, 20-25 min from CH:CHROMATOGRAPHY_SUMMARY 50% B to 25% B and held at 0.2 mL/min, 25-26 min held at 25% B and ramped from CH:CHROMATOGRAPHY_SUMMARY 0.2 mL/min to 0.4 mL/min, and 26-30 min held at 25% B and 0.4 mL/min. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Vanquish dual pump CH:COLUMN_NAME Thermo Accucore C30 (150 x 2.1mm, 2.6um) with Accucore guard cartridge (10 x CH:COLUMN_NAME 2.1mm, 2.6um) CH:SOLVENT_A 60% acetonitrile/40% water; 0.1% formic acid; 10 mM ammonium formate CH:SOLVENT_B 90% isopropanol/8% acetonitrile/2% water; 0.1% formic acid; 10 mM ammonium CH:SOLVENT_B formate CH:FLOW_GRADIENT 0-1 min held at 25% B,1-3 min from 25% B to 40% B, 3-19 min from 40% B to 75% B, CH:FLOW_GRADIENT 19-20.5 min from 75% B to 90% B, 20.5-28 min from 90% B to 95% B, 28-28.1 min CH:FLOW_GRADIENT from 95% B to 100% B, and 28.1-30 min held at 100% B. A 30 minute CH:FLOW_GRADIENT re-equilibration went as follows: 0-10 min held at 100% B and 0.2 mL/min, 10-15 CH:FLOW_GRADIENT min from 100% B to 50% B and held at 0.2 mL/min, 15-20 min held at 50% B and 0.2 CH:FLOW_GRADIENT mL/min, 20-25 min from 50% B to 25% B and held at 0.2 mL/min, 25-26 min held at CH:FLOW_GRADIENT 25% B and ramped from 0.2 mL/min to 0.4 mL/min, and 26-30 min held at 25% B and CH:FLOW_GRADIENT 0.4 mL/min CH:FLOW_RATE 0.2-0.4 mL/min CH:COLUMN_TEMPERATURE 50 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Orbitrap ID-X Tribrid MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Mass spectrometer parameters were: source voltage 3250V for positive mode and MS:MS_COMMENTS -2800V for negative mode, sheath gas 40, aux gas 10, sweep gas 1, ion transfer MS:MS_COMMENTS tube temperature 300°C, and vaporizer temperature 275°C. Full scan data was MS:MS_COMMENTS collected using the orbitrap with scan range of 200-1700 m/z at a resolution of MS:MS_COMMENTS 240,000 for profiling samples and 500,000 for U13C6-Glucose traced samples. MS:MS_COMMENTS Primary fragmentation (MS2) was induced in the orbitrap with assisted HCD MS:MS_COMMENTS collision energies at 15, 30, 45, 75, 110%, CID collision energy was fixed at MS:MS_COMMENTS 35%, and resolution was at 15,000. Secondary fragmentation (MS3) was induced in MS:MS_COMMENTS the ion trap with rapid scan rate and CID collision energy fixed at 35% for 3 MS:MS_COMMENTS scans. Lipid identifications were assigned from ddMS3 files using LipidSearch MS:MS_COMMENTS (v5.0, Thermo), which was then used to generate a transition list for peak MS:MS_COMMENTS picking and integration in Skyline (v23.1). #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak area MS_METABOLITE_DATA_START Samples S03_LysmCre-S_1 S07_LysmCre-S_2 S14_LysmCre-S_3 S17_LysmCre-S_4 S20_LysmCre-S_5 S22_LysmCre-S_6 S24_LysmCre-S_7 S01_LysmCre-T_1 S02_LysmCre-T_2 S06_LysmCre-T_3 S13_LysmCre-T_4 S15_LysmCre-T_5 S25_LysmCre-T_6 S05_WT-S_1 S08_WT-S_2 S12_WT-S_3 S16_WT-S_4 S18_WT-S_5 S04_WT-T_1 S09_WT-T_2 S10_WT-T_3 S11_WT-T_4 S19_WT-T_5 S23_WT-T_6 Factors Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre+/+ Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Safflower oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil Sample source:Mouse PDAC cell line | Genotype:Lyz2-Cre-/- Arg1fl/fl | Treatment:Tung oil Cer(d18:2-24:1) 2299109 5759087 14006518 4219303 7857869 4605489 60707796 3021544 715034 1968023 1808516 4689085 26220834 8782060 4699534 6335605 13473311 11041738 6889528 2100125 7176871 5854580 6756625 21207432 Cer(d18:0-24:1) 2381404 5940765 9453479 7834999 3968379 4278459 30568440 5112886 1043066 2202054 3415028 5819584 20729892 7477373 4230350 7009094 5422317 6321662 6112523 2815358 7505513 4686048 5472612 13240090 Cer(d18:1-24:0) 2327399 3392142 5394926 2337102 5648307 2702952 20310884 2870741 1108651 1859052 1172996 3487653 11152741 6061234 3731865 3402625 6837256 5617208 5394623 1461500 5350837 2694690 5102927 10948594 Cer(d18:1-16:0) 524178 1027871 2355076 659360 2157280 1049510 9837704 650273 156104 467954 302726 536643 3283582 1874922 1162745 839575 2557182 1649030 1576109 448991 1106434 767197 1250695 2743598 Cer(d18:0-24:0) 2651685 9734869 20573788 9867397 6899088 7519061 53146064 6388538 833431 2998706 4885758 6289652 25692076 9498463 6275139 11126008 14824839 13476654 7568836 3439844 8092520 6618156 6982163 15731618 CerPE(16:0-d18:1) 1115845 2900062 1297808 2882664 1684608 1524301 4692908 4035452 507267 1461547 1839764 2373786 6449574 4400941 1782663 2747001 938939 1393368 3484449 1739370 3068116 2332034 2256462 4221992 Ch() 1047292 4217661 8037489 3836070 3165028 2759424 25727744 3331304 396922 1480277 2620034 3138449 13549081 4589904 2816854 4398255 6235679 5237949 3430607 1732513 3832658 3323709 3207692 7534312 Ch-D7() 1370552 3184593 5512198 1828471 5505592 2179584 18102654 1693407 365527 1159022 813344 1934465 8218779 4224830 2819469 2998877 7065176 4476572 3557840 835574 3366737 1867902 2968430 7176500 ChE(20:4) 4546443 8469444 14496514 15383837 6932481 7357154 49898592 12215048 1927461 4453767 6125940 10104913 32159086 15191489 6511470 13454950 8710464 9052020 11089641 5173536 11921413 9776271 11717004 22885208 ChE(22:6) 3565472 15160208 36250144 14009405 11407195 11138313 119661432 9642167 1619371 4874823 9469717 13403651 64418984 15516072 10792348 15634079 25735434 22596824 12071955 5973615 17236172 14383548 13881009 42181664 ChE(22:4) 3449893 5746787 7042989 4006629 11554488 4094166 30351924 5345634 1551286 4280073 1811122 5767901 18205928 14532695 5303342 6756387 10909980 6776674 9916279 3207594 8550452 6224731 10683488 18198258 Co(Q9) 18561 152143 808161 235774 34414 95959 954981 187107 0 20955 65719 109640 735060 121847 75754 157232 399956 205766 185651 23096 174283 114079 101608 470095 Co(Q10) 4394133 10723195 10216425 12081906 8614458 9883756 16489791 12024367 2042850 6226909 8380926 9696909 15866721 11583139 7106701 10324716 9203027 10737431 13196502 7235336 10941321 9992705 9387884 12938976 DG(19:2) 14782274 11341714 13752536 11262312 12870013 11323062 9461359 11040686 12331796 13689872 14816890 12579809 9876516 10395597 12732119 11869499 13839885 10497807 12913951 11341217 10761696 10944021 12486390 12470527 DG(16:0-18:2) 343095 2359280 1519461 1339485 2359482 1214922 22818780 1443209 160717 576978 911940 1076349 17133692 2963955 2001029 1385903 2145102 2141799 2261010 1058918 2862474 1844693 2077130 7276044 DG(16:0-18:0) 701614 10384812 1451771 1714128 3052588 1425116 14825222 5473880 524503 1287384 3038349 3417004 18434482 4202085 2148489 3379675 3083597 2016264 7919866 2454304 4542443 3245386 3697962 10076087 DG(18:2-18:2) 259433 3346486 797342 835210 1058204 648806 3983873 2108086 148904 517589 1185184 1051786 6260850 1977412 825673 1218192 893109 805873 2375050 1835931 1317442 1336616 1342837 3056851 DG(18:1-18:2) 3343656 13514387 11087227 13114975 8015165 5232288 27863598 17205652 2018956 6342102 7822475 14261273 32354358 20833838 7993580 12463712 8505081 6453814 21721884 6373862 12142147 10447822 13630416 26303336 DG(18:0-18:2) 566670 2127772 2499946 2617741 1193484 955914 4433476 2751114 374528 1040834 1521637 2394144 5730544 3130356 1684271 2234799 1227750 1322468 3818490 988985 1809739 1633232 2158082 3916012 DG(18:0-18:0) 4520044 4487883 4735084 4642420 4154427 3708264 4636572 4904979 5286954 4718330 4583217 4561689 4069923 4087668 4259014 4763551 4605306 3960502 5603640 4562187 3532823 4924381 4503680 4572532 DG(18:0-20:4) 1587059 3069359 1181284 1792491 2651666 1334416 4860532 5545293 812025 1976188 2459594 3442459 7370534 3868476 1964786 2057899 1784288 911119 3346604 1966452 3688816 1840227 2767329 2901864 Hex1Cer(d42:2) 3913191 3151368 651472 3474821 1340555 1016011 4729778 1774921 2320415 1944552 2907338 2531398 2486752 1904236 3422987 2728056 1800909 2115443 1333756 1956235 1649144 2059689 2724101 2550816 Hex1Cer(24:0-d18:1) 1990212 3478686 1706568 2359402 1848038 1253309 4291699 5267905 1097984 1856430 1739123 3262856 6293851 2970020 1667182 2096270 2080894 1062897 3328660 1451365 2802186 1808696 2318772 2410559 Hex1Cer(16:0-d18:1) 2981426 4982692 2211930 2877901 3550663 2019514 8035163 6778053 979308 2663552 2701651 4355346 10816129 5447930 2774636 3707176 3654557 1567191 4599942 2244354 4170442 2184874 3708864 4211627 LPC(18:2) 2050987 3553690 1738259 2626012 2920760 1533468 6347514 5621318 748191 2267970 2274261 3960144 7912906 5244317 2132178 2753543 2351428 1278841 4757581 2241007 4143838 2241411 3560670 4458705 LPC(18:0) 11476762 7737511 882731 8598762 2258242 1920478 3678809 2019914 6855172 3629982 7920752 6895599 3237133 2831446 8960392 6601294 5257932 5213158 1624880 3918749 2776169 5097990 6248066 5546715 LPC(30:0) 1779242 8291688 2724903 8194558 4234529 2942427 5398476 9269770 1700680 4190903 3716981 8898735 10135542 9391013 2955459 6476215 2677079 3034723 7582323 5238396 7996818 5393273 5939502 5143961 LPC(16:0) 659036 1416611 1317461 3752924 1573741 2273098 2848446 1045540 155499 742057 1662302 1073438 1932688 1826241 557571 2701385 1890804 1974452 1320035 986341 835979 966928 1044972 653924 LPE(18:1) 1373912 2395641 1637405 8357196 2397049 3002913 3956349 4735593 832789 1761422 3417820 3556098 4342550 4524298 1374538 5267893 1779840 2441092 4401565 3119672 2785387 2910892 2913294 1758201 LPE(20:4) 785677 1368705 1559396 5473559 2308816 2314808 5822739 1674663 355728 1261049 2724853 2025378 4010611 2438510 771863 3827997 1928999 2279005 2045543 1767098 1731391 1942247 1689360 1478410 PA(O-18:2-18:2) 1527910 3198614 421241 1395538 2332853 1131830 2112228 8817924 198405 1082832 3598141 3154414 3369808 4706962 1386763 1743796 2556238 729114 11481423 1367410 5217121 1892994 5263860 1979574 PA(O-20:2-18:2) 775229 14340226 946494 1843649 10896093 2060593 2727968 5274826 585939 695625 10379509 1308044 3185555 3151020 1472970 1741822 19500682 805857 6053889 845046 11583521 1145659 22740686 3719516 PA(O-4:0-15:0) 377798 853075 1135899 3369782 1188522 843036 10141054 2837864 80556 569802 604204 1119503 5445348 3038286 518052 2730575 1042308 1336324 3910537 785938 975678 1219410 1050652 2394868 PA(24:1-18:1) 899985 2688883 375685 1099244 2091550 707640 1445245 3832627 120834 607167 2182326 1450164 1992918 3214107 958850 810672 2533524 373715 6329466 723112 3869262 858104 3468026 1211818 PC(34:3) 3651183 3809247 845763 3746072 3853780 1374148 2039559 11913671 511587 1881575 5095855 3861018 2582472 10116980 2104609 2933577 3529746 435989 17819632 1079606 6282200 1335415 4925398 1787831 PC(34:2) 8684941 10942823 2875730 12608030 10688585 5196963 4522631 32051828 1002362 5519339 17385428 9972783 7392035 22782106 4743758 6263569 10766601 1327713 39491960 4145310 14447945 2966938 12407046 3426318 PC(16:0-18:1) 74656 3060591 1126067 5100777 1308525 1121300 14214421 8781468 234291 2527312 1439927 4369007 14565571 6210374 1158421 5349975 743123 2281604 6426325 2117065 1851129 4718460 3553378 6517617 PC(34:0) 50435 2105846 846744 3346815 603018 676738 10908528 3424021 133700 1108647 604219 2431352 9280868 3684086 618213 3458583 566111 1561533 3265375 1193072 1040498 2676329 1569968 3674066 PC(O-36:4) 2563500 2233297 2327610 2060866 2176792 1644188 2589548 2365842 1972518 2379653 2398633 2552764 2485226 2345905 2096911 2435003 2448557 1973424 2468232 2515024 1734478 2452969 2527503 2473656 PC(O-36:3) 2647870 7013030 1014773 5871117 2979607 1997474 2649979 3069401 1117237 2479385 3479543 4320586 6548641 2864574 1495230 4934733 421672 1853290 7002404 3464331 5857354 4216116 1639031 1316918 PC(O-36:2) 808696 1681946 1489729 3177817 882810 636702 2159428 7968538 274241 1224406 2788392 3404280 9054234 2176842 741936 1840706 1043063 662427 8155207 1781745 1848987 3039301 1816408 4241986 PC(36:4) 3805112 11270461 837676 15097398 5556269 3909543 6514853 25912286 999013 5378062 7438069 9723638 18735842 17307048 4323758 11163050 996663 2410800 19530724 5041554 4598070 9629334 5730160 5685405 PC(O-32:1) 96116568 386148448 58295852 378898944 132927968 131731272 200525872 564096448 34980460 141661776 197844432 246287632 536552288 406185856 127582000 298083360 73422000 109845712 467022560 142831952 153218320 248779040 159710656 175912288 PC(18:2-18:1) 9193160 35633116 16332189 44483344 12914684 16292595 45686520 43950628 3364019 13865728 14864433 28374408 56075092 44935960 15649918 30804020 15661423 20166394 42141156 19965350 17134384 27958678 18433086 29186370 PC(36:2) 2757763 10423604 8521257 26530578 10250882 9944367 46548256 16000674 1367183 7171699 9668988 11196977 40932784 16016524 5130234 16509002 10925664 12522791 15228385 9356886 9042449 10360653 10372610 16400029 1-PC(36:1) 42238 154087 94800 326208 84789 30387 1136538 165999 16122 64015 113812 148849 481102 327307 59384 300157 86430 119634 165535 97810 108026 183530 178447 163316 2-PC(36:1) 534238 1441175 1515694 2289221 535860 608815 12142452 657206 964498 863077 547956 703440 4388291 1914884 441123 2603279 2679552 1246186 1314507 364853 210335 282958 246233 1242540 PC(O-38:7) 6927938 20691432 2304434 19484310 6891983 5973306 11027274 33348912 1920176 7433123 12625747 19070232 29834370 19318166 5435006 19185320 2871790 4795900 29034294 9975908 8356950 17738626 11355496 11071273 PC(O-38:4) 80790 3964695 1314431 3030011 760002 1312953 7715655 5655736 321982 1278740 495162 3498696 15818900 5315494 1291787 4105058 727739 2301705 4352140 3362117 1823855 5222152 3347525 8510819 PC(22:7-16:0) 25923936 91334584 10361013 89104296 35955688 29837618 51258620 135166896 6650579 28170596 47790540 72734640 112466712 107987056 25782470 89762440 14379563 21202400 133806216 36722200 29668104 63460284 42814284 39799260 PC(38:6) 44458392 170816896 25861892 169004752 64025476 55578768 116402184 268456320 15804805 56274756 93509576 142114496 264302592 207610512 51437408 142464880 31113260 53846760 267209712 99320288 77548992 150765200 100582648 103555872 PC(38:5) 369573 1767166 166892 2129424 490370 371535 1190812 2070156 187913 463423 579236 1202468 1320755 1860517 486897 1340978 403735 423233 2195920 351999 540989 786254 459098 318904 PC(38:4) 12428210 54592312 11101653 67719568 29530780 24118778 48993456 80872872 4984423 22059994 39415464 57286688 120766424 70546376 22219614 54965192 12882810 25374758 70647176 46962972 30259582 51441808 34369572 45664024 PC(20:4-18:0) 2522 2222093 123727 313109 90245 133610 1684452 2414666 44317 473343 235155 1496119 7538047 1575142 303386 950877 62430 411950 2060978 1294759 595919 1907020 1136172 4774093 PC(38:3) 561515 1789292 1207995 3275768 1154871 1388497 6148045 1516819 85070 1003022 1362611 1335349 4707175 2157225 775301 1912584 1642517 1652192 1434837 1701656 733203 1168058 1529562 2261829 PC(38:2) 193299 1583579 156815 2390966 873060 843991 2002924 2741662 73505 804148 1477365 1967264 4883689 2155559 551533 1869166 296842 786528 2024135 1311276 1079873 1845334 1139041 1282801 PC(40:8) 4374279 30861958 8567822 36231580 14445207 12902356 56228056 53046072 1649610 10126965 22625598 31957774 90357960 34456360 9302138 31818210 9799156 16268824 44580856 13490371 15154493 25589404 18804472 31445344 PC(40:7) 3703471 12553229 1659944 15392884 4693970 3759572 9629337 14210755 683090 4104046 7580537 9267296 17283470 11457689 3724723 11374282 2470597 2852772 16446123 5236536 5083984 8346293 4638830 6540722 PC(40:6) 2188077 14448613 1170845 10557865 3647808 2232679 6133141 18471198 531304 4243230 9218690 12081121 16415552 10580271 2272964 10169828 1615151 2503340 16507457 4705675 3798700 10198023 7945374 6664181 PC(40:5) 49886 658112 88214 441974 166321 157022 305009 738539 5219 75747 147309 467048 603200 533250 185441 391775 73624 197794 280611 332044 204777 385006 303814 271393 PC(40:4) 148507 621238 93264 814259 261637 295236 652232 929868 28823 175932 294596 630871 2452658 1258205 363358 898593 96839 309529 782691 1006127 266170 1056963 528233 565212 PC(31:2) 2117282 9428035 465718 7293974 2593462 1905717 2876865 9479681 369722 1795737 3264427 4293815 8635913 10408463 1938442 6859281 790949 1238323 11036898 2420022 2050891 5173023 2996917 2434183 PC(31:0) 1512484 7189304 1643330 9379703 3959169 2841734 6735995 8199369 598180 2752852 5580776 5603939 10402800 5905604 2179022 6285529 2250918 3446400 9122574 4024009 3282883 5635238 3223034 4025964 PC(O-32:0) 1152364 5982462 1349102 6541270 2344140 1493442 7629764 7094759 373149 1438892 3696889 4821162 10761055 7193130 1319916 4497712 1408745 2355106 9990116 2644086 2181911 4323362 2643343 3670696 PC(32:1) 257225 1447427 109426 1262117 926616 243644 559121 1520258 38945 405246 677552 1149990 1924167 1132554 295251 1308571 127850 355579 1477188 687920 282563 933590 762351 946034 PC(16:0-16:0) 574882 4361230 803858 3807919 1639496 1268325 2378824 3833500 204791 1204531 1673226 1434790 4473838 3846920 1145885 2409809 1278612 1471539 3776405 1383189 1365976 1726931 1306279 1844141 PC(33:3) 1506712 9691063 2510212 8684221 3130456 3066529 5964427 9619727 444140 3037837 5262421 5819218 13015159 8195670 3539029 5876426 3101049 4123642 9743182 5388218 3945246 6033723 4785407 6366534 PC(O-34:3) 1280139 3561839 628425 5010023 2214059 1505897 4529929 10642309 258171 2520911 4227414 4511522 8395651 6441551 1678021 3688298 1065346 1518715 7736713 1593044 3076475 4090834 3391231 3764611 PC(30:0) 868582 5160299 2276131 10005654 3273998 2383422 6261495 6875015 387556 2553658 2805210 6087711 9251184 4891455 1315199 5776809 1546796 3094036 6664515 2684797 2625007 5730064 2708078 3559970 PC(33:2) 2951849 9315652 20146350 20401994 7160946 10871114 117039104 8021393 947362 3897382 3528932 7615826 51567216 12284888 5364162 15538966 22597514 20276070 9581012 4947139 5611226 8362590 5842604 13614111 PC(O-34:2) 7375699 15972467 2578106 33040242 11175275 7621690 12994621 52772268 2634494 13892155 14195032 18129376 36348656 24158278 8339765 20058038 2771814 6071498 29964428 9678768 11664651 19107260 11359092 12983185 PC(O-34:1) 35585304 140130656 69445344 245033584 66868428 80676968 181875376 171519408 12259256 64343860 69497000 119431704 266929456 157246720 53959640 163886560 57401648 97126952 141894048 69198008 73239712 121115992 70011288 94794000 PC(33:0) 3389693 8760869 981253 11055669 6441253 3376063 6644969 22443810 386258 4588506 8790407 8800357 13963761 17836100 3243482 10017942 1298151 2342412 23444230 2888117 4586439 6989797 6522411 6666565 PC(O-34:0) 65854 5046910 1108678 2651314 957242 1266633 10603982 7349155 391857 1941769 873218 5021579 19499282 5449090 1713639 5682566 678481 2675845 3839039 4588482 2371009 8197698 4704019 10497726 PE(P-18:0-20:4) 16372467 65361012 12922928 96064712 23636674 18662650 91339960 129881624 3729894 21944408 25725294 56922344 152028624 86520512 19352530 56749672 12655501 21945142 110880848 27557382 28699562 62638132 38239484 55398928 PE(22:6-16:0) 2906840 7685853 827579 8549857 4730926 2758499 5053574 15098187 355718 2904420 5297403 5177850 10414194 15765939 3198720 7550813 1363981 2014615 17245172 2097033 3672679 4974520 4266411 4666191 PE(20:4-18:0) 2828157 10240104 11653841 21917346 7545465 7348209 75972760 20442212 1442911 5331321 10321016 13091503 61603564 16020449 3879798 19587920 14788502 13263096 22619592 7919759 8777928 12089803 10693155 18574376 PE(38:4) 6266625 24070460 20527934 37841508 14348817 15514783 103853200 18196400 1586244 6874417 11021805 14873468 53458180 26148976 8720469 33880916 27670224 25324664 21411130 9649909 10466225 15496361 12484785 18790400 PE(P-18:1-22:6) 2171170 6810740 3801548 9236508 4499191 3204175 6351548 2306920 922337 3147750 3372557 4986512 8294363 2008735 1488889 7182200 1122504 4939417 3772720 3859543 6239917 5375970 1515934 1463134 PE(O-40:8) 461334 2035719 3515110 3766152 1166777 1843081 15287581 1951906 97437 620731 715107 1755028 7084728 1926409 843582 2992966 4395580 3533071 2163099 976241 1151351 1666841 1155702 2713041 PE(P-18:0-22:6) 231800 7295516 401317 14885149 768201 1388056 21226674 10772891 157845 2210055 1257695 6738419 32168950 14859265 1387463 7589591 134530 3277878 8763592 4649997 1640922 6834159 3509882 9049526 PE(40:7) 501695 2339539 282378 3600826 1497226 1049951 2150757 6179712 64963 1377255 3328556 3117770 6288595 4475093 1325912 2863127 456051 1047875 4581900 1163585 1965022 2214746 1860301 2238663 PE(22:6-18:0) 6049770 17199270 4850508 36198872 15556171 11250265 25865890 35406568 964483 10038573 21445594 18593742 47726492 36094256 7955918 25163716 7275401 11361066 33282922 11031417 13107555 16895840 14325318 15984995 PE(40:4) 765761 2112057 372488 2366667 1011522 852024 2419492 3115883 162782 806963 997293 1524126 3323984 3923175 949756 1939585 554712 632235 3407396 799242 1140812 1334950 1493662 1667393 PE(34:1) 61576 3218586 500793 3384663 961617 1070645 2554661 4705811 230352 1225562 1448826 1825192 6700376 3890556 1128013 2663345 559920 1651369 4077691 990520 1116030 2163164 1108840 2850924 PE(19:1) 46300 1251936 259986 2183950 371646 438579 2988798 1767862 97458 565804 452152 1107342 4076420 2285362 491669 1260571 271921 770686 1429693 837846 541364 1108632 843830 1532452 PE(P-16:0-18:2) 64890 2831375 546800 3880363 579192 696263 4879790 4959841 56015 1165542 1036813 2679703 7887221 4727013 1257304 2210239 360941 1247367 3810503 1397281 1061427 2357969 1357303 3597905 PE(P-16:0-18:1) 555538 1366524 455454 3277255 1571924 1075990 2590326 2890220 56272 862355 2154837 1506831 4162442 3092100 726524 2171145 764807 1113619 2633252 936723 1363772 1636144 1364579 1653929 PE(34:2) 1078678 5282037 1464850 9468029 3363197 2881308 5473516 12073243 200573 2617349 6826125 5510600 11514152 9101377 2513671 6319727 1890088 3143188 9806986 2407552 3192032 4247833 3929591 4772116 PE(P-16:0-20:4) 1105001 4388358 1444119 9459013 3175085 2343327 6068489 6660901 128498 2161187 4336173 3427660 9179605 7158742 2118302 4672431 2238988 2583245 6732224 2362080 2445059 3148556 3758888 3549155 PE(P-18:0-18:2) 2359054 7017223 1050921 8520745 2998341 2611213 6942667 15031331 301371 3252263 4893819 5543672 12760127 11576804 3151014 5521422 1790428 2307713 11194700 2272001 4117591 5595128 4533294 5651984 PE(P-18:0-18:1) 401824 1353846 626608 3353440 1326861 2503762 4183405 3929348 426076 952517 835620 1339407 5931920 4149530 2118804 3740331 513166 1799669 2013878 1297774 2697412 3770578 2656673 3277232 PE(20:4-16:0) 74650 3287072 1120155 5059637 1309113 1118019 14464143 9053547 234292 2497457 1430250 4312824 14528005 6166990 1153310 5395481 743138 2288727 6271026 2102342 1838827 4958591 3526313 6441966 PE(36:2) 178315 6544728 1208190 9984582 1945361 1954454 19373968 11655774 375174 3312870 1796576 6738404 22684942 13845295 2521125 10428591 917782 3181018 9517635 3556555 3023628 7875144 5214007 10754613 PE(O-38:8) 1284385 3698351 628425 4499853 2214059 1497258 4313003 10285115 258171 2395705 3924907 4300530 7908923 6306739 1628139 3698313 1065346 1498940 6990761 1541708 3004283 4051797 3468407 3660802 PE(18:0-18:1) 673797 15723145 4094487 32225764 7474498 7206121 39472552 30150958 937534 11159859 7566771 16422640 63106372 28726582 6635682 20942190 2808572 11181533 20417154 12795623 8524425 17448746 12175626 20398678 PE(P-16:0-22:6) 50437 1870491 739086 3325924 603017 676795 10586775 3569520 133898 1226231 600607 2275027 9535199 3737527 622999 3247483 566155 1647458 3225841 1170870 929692 2481260 1787287 3614869 PI(20:4-18:0) 84419 2355173 640545 3765017 550328 776944 6757901 2927861 153704 774461 522649 2506860 7769015 4736033 870555 3695965 373492 1265147 2969786 1117955 1095936 2395203 1777582 3694006 SM(d42:1) 1074110 3633057 651761 6406648 2562094 1823956 3891623 10692118 175964 2214598 4640556 4225198 11093497 6077693 1578884 4188724 994087 2046913 6825484 1788300 3097378 3489704 2826374 2988481 SM(d42:0) 5233229 13677629 3294662 21037346 8281450 6543967 18204316 34701420 1118615 8343342 13851373 15618893 28616282 27589634 6018399 15215078 4807156 5895482 33001238 6743659 10757659 13695372 13148701 14941779 SM(d44:5) 26316 1481820 302604 2757405 617582 613642 3916465 2642288 26720 921309 611602 1562053 5613879 2793944 621595 1963715 209841 1000837 1860542 1189066 746457 1689506 1174808 1857965 SM(d44:4) 6114193 18327326 3457489 21476488 7341073 6540768 21069980 26771496 889348 6435849 9111196 12974891 27724964 34916576 7376619 16849206 4751447 5865984 30044052 5986475 9613156 11949450 11826319 14909666 SM(t22:1) 61037 7512771 1318558 12459045 2525163 2297376 14313687 15714292 56557 4304296 4087508 9260564 25420590 12094810 3679028 8638728 898812 4030107 10349349 4102359 2959743 6904651 4007361 10253479 SM(d34:1) 4786098 34155364 4521478 25738428 3258895 6457079 3027186 46832824 4537620 9008690 7238583 31347220 15787376 26969796 3206015 16851010 5035269 1050185 37238560 11983088 8453318 6023383 19181056 5797871 SM(d34:0) 1621905 2033450 691782 1763473 2267979 2101044 3561432 3825203 106096 808161 609929 1321125 3997441 5253619 1351360 1457044 2197831 886720 6469567 644617 1414154 1720864 2378673 2733189 SM(d36:4) 2553833 2456289 525621 2498995 3468568 2245143 1854484 8201258 456236 2230568 929240 2369177 5161594 6461321 2204837 1476027 1797390 845205 8885600 1178076 2984928 2569397 3920890 4672069 SM(d36:3) 319100 1257142 587208 1094239 469565 962107 1718988 1585109 21350 182970 585794 533321 1921915 1079616 433591 980245 1331988 561082 1628687 278467 444408 573484 751165 852033 SM(d40:1) 501132 980649 214568 1432796 401473 716265 889947 2771234 31009 247881 541373 949883 1890016 2103786 495415 1063647 436398 224307 2162829 356958 834420 697174 960377 1210259 SM(d40:0) 179674 3298777 3051543 2636977 3109016 3537739 2101422 5388564 1527033 2483416 3747997 3279539 2750844 3956720 3554240 3247609 6331125 1377815 6484607 1952764 2733143 1986045 5919560 6503807 SM(t40:7) 13115537 32144688 15079125 39161568 18499108 32290246 54472140 76382496 2305739 10942160 34241872 26614262 76160936 42985152 19768926 32528752 42040904 16207906 60538504 12279357 25277384 24715050 35209884 50882696 SM(d41:3) 7295056 7954221 2674694 11472510 7057490 9589646 11167983 25034726 1059674 4412306 4450728 7879278 19591418 21499740 6539008 6342335 7034216 3577358 28159430 3747362 8614228 9468266 10700081 14660228 SM(d42:3) 774026 1896838 843709 2306431 1074278 1873846 3488396 4591027 95442 552408 2026931 1521630 4719867 2658042 1257241 1984262 2528719 962448 3607606 730937 1521580 1363035 2154009 3171706 SM(d42:2) 412614 482848 131098 706457 458989 593790 633598 1713777 21293 247230 256342 494550 1445721 1408092 367571 334487 409187 185770 1842675 161954 493108 578501 693823 905099 TG(12:0-16:0-18:2) 4416539 8430669 2032991 10139419 3431633 5842426 7141897 18003548 675723 2301429 4755938 6195024 14278713 14375812 3572547 7815615 3962192 2172499 17004168 2828514 5643374 5053135 7271468 7745584 TG(34:2-16:2) 2366422 2150467 417152 2783627 2408973 2178168 1824755 6370239 351113 1308193 842922 2197278 4688371 7358481 1664371 1494279 1295624 609624 9858563 1137752 2418880 2466401 3391995 3706341 TG(16:0-16:1-18:1) 12027038 18641610 16362960 16712354 13220165 4825852 20110854 15665439 6181052 15666060 20217430 23359156 19225794 12602742 8660752 20596982 12538643 8917323 19029742 16682480 5462192 18883650 16074025 18057088 TG(32:1-18:0) 3383738 4976712 4517832 4480515 3639974 1060291 5835978 4193025 1465944 4566162 5242255 7191906 5391335 3458794 1914659 5877418 4074804 2663548 5557989 4682489 1353304 5577757 4778006 5440310 TG(16:0-18:0-16:1) 4129472 14530834 7093380 12691838 5796095 11932150 21598854 19265038 501759 2415366 8091454 5971853 20419282 15325729 5889655 12095143 16034075 7369265 17692430 3380543 5342122 6376645 8615016 10490641 TG(16:0-16:0-18:0) 5674096 6818812 6247544 9056607 7370498 6639318 7718738 11092137 5941926 7108088 6789300 9356914 16055070 11332362 7398727 7792359 6827654 6832909 11590300 8279131 9579813 7210838 9620441 12865607 TG(O-16:0-16:0-20:4) 1634824 3960623 2087733 7172847 3273266 2289592 4714920 10674551 1788812 2915527 3487775 6126805 18473412 10883076 6466953 4260015 2933357 2165310 9000575 4462007 5681252 6024989 4331442 13245834 TG(15:0-18:1-18:2) 28607444 38462204 21914366 56356020 33285960 24461846 36635704 64379596 16222292 27542208 27030946 55816176 106382544 111445848 40085808 46725244 38397332 21970612 61606420 29641674 34338900 34437136 47949736 92129544 TG(O-18:1-16:0-18:2) 4674998 9045783 3998344 8857638 6628902 6522714 7747388 17290352 2983388 5827109 5343337 12350517 28606552 18202536 8550866 7921990 6910373 4725402 14232959 9441098 7120440 7310808 9161275 17945792 TG(O-18:1-14:0-16:0) 54495084 101689392 62732288 138128640 80587448 74056768 121235000 220694848 41750928 63125564 68023008 194817120 347582432 314928576 114488728 128832816 98742456 69640128 155350720 92443280 132830608 107763376 128880560 286689664 TG(16:0-17:1-18:1) 16917786 34297732 20212442 42930520 27824654 30101672 74028168 75410568 16066194 22457550 24784900 55077508 194488560 86364240 40260920 37343744 28914672 26234646 50279848 42909776 50663616 43485016 44827504 100986648 TG(O-16:0-18:0-18:2) 839612 2587212 2015087 3071364 3661753 2189420 10835776 5931635 872362 1919592 1799932 5431021 19112686 9566066 3489913 3217910 2654121 2697627 5861493 3725398 5207950 3183302 5116118 17499028 TG(16:0-17:0-18:1) 3443320 5995137 4328132 5918270 5436191 3880002 5591528 8038082 3469339 4322895 3300736 8134223 11936914 9695182 3843579 6530086 4986408 3791777 7147648 5633744 4813953 6717425 6960765 10579804 TG(O-16:1-18:0-18:0) 1441125 3512500 3040345 2908349 3903410 2663065 11910032 4964863 803619 1789192 1934914 4921614 12227318 7741207 3045679 4515102 4586404 2958511 4945613 3243288 4155769 2334070 4432747 12000648 TG(O-18:0-16:0-18:1) 915785 1190198 1004272 2132505 2124317 1522730 3272502 3390589 666225 1097140 1036714 2172064 6080519 4806643 1748943 2595417 1451569 1341148 2630565 1661420 1993879 1055320 2664961 6683707 TG(16:0-17:0-18:0) 3904108 4108762 4523985 5683944 5567558 4689783 6958748 7246128 3697331 4945393 3242956 7579346 12836449 10877753 5409801 5708291 5539637 4678990 8868664 4793275 3789315 6375892 5938400 10590334 TG(O-18:0-16:0-18:0) 886373 1648192 1764958 2576226 2548218 2277569 8562588 3500971 835856 1382975 1224836 3943309 9507635 6082300 2070008 3378309 2690265 2465923 3757834 2397521 3693622 2214712 3875254 9066037 TG(14:0-18:2-20:4) 3249138 4746217 3488012 4635916 4808863 3572115 4955318 4811692 2985401 3150219 3785175 5724421 9942906 8539583 4548268 4871552 4089135 3902025 6234767 3909190 4577010 5175649 4742567 9292909 TG(16:0-18:2-18:3) 682186 1309098 954894 1896890 1467809 1200971 3417824 2619892 439621 882305 711378 2176931 6489439 3917131 1459179 2082232 1523885 1528737 2265106 1580210 2056163 1318346 1999140 4622909 TG(16:0-16:1-20:4) 2283450 3809340 2675657 6403250 4291567 4071020 11275708 6109140 1493055 2405189 2676811 7479013 18344370 13429434 4896024 6777896 4085061 4030344 6544803 4980722 6618761 3483981 6297019 16547539 TG(16:1-18:1-18:2) 1268823 1684582 1406482 2164373 1677771 1450345 2388965 2129363 1165200 927110 1527500 1774048 3799617 2579097 1482293 1533989 1621332 1515921 2000208 1902676 1705046 2337878 1740089 3255159 TG(16:1-18:1-18:1) 706302 1142260 780336 2458042 1569664 1673723 5590871 2147951 715180 929922 1036216 3360818 8121471 4215397 1924240 2527382 1136918 1380273 2214102 2331966 3072705 1515184 3171569 8238546 TG(16:0-18:1-18:2) 2368022 4775499 2086092 9063933 3197606 2394493 4910789 8527627 1538733 3335650 3558090 6783193 16961722 9793793 5709413 4984489 2797476 2078544 11800013 4736914 5170289 7682533 4149833 9235192 TG(16:0-18:1-18:1) 5031101 8633167 4415375 12131202 7734626 5575183 9562598 14375283 2860228 5306510 5508116 12732557 24760032 16851084 8509796 11769704 6715730 4424880 15873726 7427799 9045738 10067661 8200673 18821250 TG(16:0-18:0-18:2) 4247935 10757264 4783819 15988055 7430400 3883034 11480700 13923149 2933667 6069235 6497816 10673010 26621714 22319466 13488843 10297112 6135127 5258758 12824824 6724186 11091151 10617267 5812327 12929144 TG(20:0-18:0-14:1) 41711536 61347232 41891408 71227616 70249072 43291728 89088528 110401920 40001732 44492896 43423140 106067344 169799728 141398240 54696204 109883560 55225664 44256788 98754320 73242904 88358904 75471256 61828228 115686232 TG(14:0-19:0-19:0) 12266864 12179810 8575632 19515022 10734948 9143091 13244902 17668164 4899813 9096628 8259752 18855418 31048690 36543476 14669903 17822556 15461862 7289547 17945308 10030674 10082489 11900342 16087892 26980564 TG(16:0-18:0-18:0) 92241552 210085120 89304800 143015024 148213680 127850624 190578352 291113152 50076424 91083520 95079080 245496112 390917184 367095712 174412128 205815760 162700624 110109384 261554736 135230992 166823664 141138320 157081712 365618976 TG(O-32:0-22:6) 76572296 134323344 87794896 156009056 98196528 96266016 145752272 214345056 53677240 66421260 72288512 201155344 380659552 373228160 133612440 183943536 135041552 94223184 180218544 102208248 134314592 118474448 139697248 296803712 TG(O-16:0-18:1-20:4) 44800832 85587872 47670768 109799600 94962208 65087404 143977216 155576912 35234772 57728304 65544380 177896192 379790304 331254464 97868856 108069752 89886632 76946064 180479424 89816576 124422464 102157832 137161232 273449536 TG(O-36:3-18:1) 52018712 103104312 57320268 140661536 82255432 76690176 152838480 192110032 41109640 59080964 62734976 153932528 524183648 333135776 105404432 117333360 83666248 74222392 192038560 96966680 125119104 103560816 125201328 318536320 TG(O-16:0-18:0-20:4) 4811537 7708306 4989749 11235983 7888215 6807053 13499609 16289840 3899163 5750814 5883648 13863944 42765316 22051090 8969097 8076538 7535260 7417055 14438936 9838343 10893026 8833750 9131194 21669948 TG(O-18:0-18:1-18:2) 34570840 36434876 23226310 64689684 39484576 30984012 71695424 55548720 26905438 26370208 32516508 66117776 122853064 76437824 44820476 41672784 40395980 37021340 53655688 47640140 47880076 40654756 52475496 102455192 TG(O-18:0-16:0-20:3) 1516065 4914697 3046818 5860741 4501025 2877687 10918177 9548761 1304328 2648586 3123251 11270799 28190252 16706280 5313779 6866032 3993749 3211798 8211364 5928301 8359308 4915589 8188371 24040422 TG(17:0-18:1-18:1) 929376 2974064 2752866 2863543 2917277 2253081 14729687 3951474 684704 1111257 1616181 3816892 17608262 9152164 3987177 3149839 3768577 3558274 3874269 2487058 3614238 2395653 3051367 9100452 TG(O-20:0-16:0-18:2) 234027 950741 757719 619437 666783 662703 2973180 557264 73307 168570 254135 677544 1462780 1791636 714609 1403672 1601881 944039 554155 355235 480633 246856 472597 2031144 TG(18:2-14:0-22:6) 401882 1107687 1048956 1325425 1563145 1151304 5335140 1487985 353097 684971 929781 2186458 8725145 3929020 1669484 1331979 1682916 1348107 2233287 1708639 2584161 1400488 2138308 6906021 TG(17:0-18:0-18:1) 793392 1484652 1455087 1941752 1932318 1229217 6136462 2248976 464442 971194 829017 2571880 5745047 3863153 1427889 2738241 2356525 1790057 2712382 1523867 2247237 1383741 2014514 5473671 TG(O-20:0-16:0-18:1) 366770 1430685 784983 1727395 1416491 884593 2321938 1826845 286798 695755 792075 2029115 5451181 3556691 1179932 1551599 622993 1230904 2442445 1281589 2193140 1239784 1968494 7169575 TG(18:2-16:0-20:5) 1708916 1924888 2121477 2173985 2284776 2052114 2594074 2795526 955917 1311251 1871207 3176111 6261183 5154907 1853967 3422452 2381624 1628977 4258689 1364158 2440536 2233692 2673979 4456419 TG(16:1-18:2-20:3) 702415 1163728 919851 1609068 1755566 1282778 3502878 1612138 317720 643755 826024 1528581 4045154 3895140 1192107 2085001 1544889 1149192 1822860 968421 1279428 1057060 1419396 4234890 TG(16:0-18:2-20:4) 834862 2940668 1074215 5273874 1825803 1080084 3050823 4780406 627164 1603073 1422239 3351685 5415030 5002368 3746534 2282922 1526008 1052195 5898021 1902757 2752188 3598393 1929517 5619573 TG(16:0-16:0-22:6) 819342 1751227 1361838 2228058 1705515 1613509 2047461 2105920 862579 1230231 992690 2807951 5570099 4747776 1897262 2076059 1936429 1545383 2704534 1645254 1827864 2282988 1430379 3911783 TG(18:1-18:2-18:2) 772443 1300434 787915 2460453 1526419 1394843 3838132 2200496 488893 890648 855887 2749968 6555142 4319194 1630946 2620777 1304909 1425412 2575533 1692259 2342528 1394393 2433856 5994407 TG(16:0-18:1-20:4) 15562621 21146258 15406057 27237912 15635149 15200669 22382610 23751084 11824991 16155950 19033000 22642128 36426496 26524672 20549122 21875142 15983006 14934857 29639064 21112826 20032526 24535194 17170508 29766628 TG(20:4-16:0-18:1) 51240924 64894660 51161696 58741116 50992876 53273792 67948264 68610360 43264464 48341016 42453012 81386656 108212976 81660392 53202152 70856720 53688012 44978244 73404824 65750824 58268708 75102208 57674248 97508976 TG(18:0-18:2-18:2) 16320075 56562312 18796820 64004008 24230662 19220314 60408312 75754920 13524367 23499150 30117720 68874896 159209312 103183016 49574388 41535988 23564964 17363252 76748624 42847356 52184304 64169468 40138852 125447336 TG(O-18:0-14:0-16:0) 3549282 9267098 3491681 5807382 5020254 4114404 8794784 22894094 2625906 6265393 7243675 14870756 33048248 18980510 13988663 5585439 7604380 3473840 18378830 7357762 11112794 9209531 7506603 18937272 TG(16:0-18:0-20:4) 78839024 111836888 74724712 122145064 104788624 81923576 125742304 138542768 53328296 62821260 69551648 143104272 239661312 228880736 97181120 171648576 94930912 82842760 147364832 100113512 95584712 106827072 100919816 192719792 TG(18:2-18:0-18:1) 29960436 86520272 43735444 86309656 47724728 34251376 91016336 91900968 18878092 45374412 54063220 97423888 193618784 145936144 76758928 73647040 64850620 40326804 89829896 55491272 68576720 79734880 62473060 186075680 TG(18:0-18:1-18:2) 216091 258470 335956 409351 329317 234739 430945 335537 182413 260941 277578 230964 442801 567273 285301 309279 237112 223509 360936 209191 384090 368332 273489 872386 TG(36:2-18:0) 79649416 153935456 80880224 119540024 114045016 105610424 139604592 153474464 45147412 58511652 62191180 162884992 297876896 279365344 126331320 204430016 138369088 90234328 176127936 89758704 95381184 95381896 107600280 239651536 TG(16:0-18:1-20:1) 919134 1207873 1276537 2994218 2448648 1928623 6294203 3725185 1002918 1539501 1368343 3403906 9439441 5458344 2114780 2394723 1842194 1907003 3182556 2306304 3440212 1789198 3520150 9377130 TG(18:0-18:0-18:2) 1277600 3223204 2293224 3821009 1796671 2017568 4953409 4935749 1575853 1781204 2781412 5299338 12397435 6832029 4204735 3217833 2766774 2439394 5428036 4147811 4880321 3934022 3211278 8332984 TG(16:0-18:0-20:1) 12292253 20859420 13115548 19266484 16673011 13176921 23027400 35268772 9790464 12472734 12844885 29901972 50728484 40973800 22192350 28093080 21028094 18233086 32809920 18394528 19524646 20763554 22751386 42739472 TG(16:0-18:0-20:0) 61184516 123774624 63785748 139095424 118743568 84417728 157600256 169207392 40132336 63875076 70562792 206223424 382250656 449087232 120752496 180018864 118902728 97811800 227472784 94459560 130308696 113932168 147667120 301856352 TG(O-18:0-18:1-20:4) 9589487 14752751 10801335 19782878 10704101 11781123 15724467 24888524 6902663 7061901 9099268 19167914 38781336 33418384 13260506 19992464 15275186 12557021 21537376 12623587 14846771 13235071 15519073 22800516 TG(O-16:0-18:0-22:4) 42838880 92571488 43078392 111221472 63034176 59399896 102425768 112727696 26938700 38719884 39925996 110004160 341937440 278560864 76435552 107849216 66921328 61744468 155667440 59730316 80415808 67393200 80221264 224401216 TG(37:1-18:2) 20516142 33764252 20269300 52015288 34524380 29730424 57075092 82384472 17121852 23800406 21684728 75775448 188151056 118837704 37588848 41603208 31450616 27264748 78018968 50194028 46852356 49694240 57480472 156049472 TG(18:2-18:2-20:4) 44643204 58979920 34428612 117069616 63808304 54042124 83243584 87894088 31391478 39159000 42391260 108106608 223591472 175200384 66963880 78179544 72154600 51631720 113803312 63903312 73637080 62769056 76581392 167309536 TG(16:0-18:2-22:6) 12927717 11579700 5020004 15927523 7776272 8858474 15780820 9700780 9991980 7422143 11189550 17174102 24713994 15419081 14676737 11545861 8746913 10452702 10019052 12766121 10169691 12666646 14898043 23144828 TG(18:1-18:2-20:4) 564616 1832263 1452921 1750565 1061234 1210759 4192160 3274600 300724 878782 930039 2465681 10045774 5108607 2624914 1819257 1646564 1571494 2126801 1898798 2396648 1630170 2078358 4835671 TG(18:1-18:2-20:3) 541280 1319903 939892 1737878 1663178 1016561 2407375 2334632 403504 903970 1014183 2572036 7656584 4509140 1915012 1294908 1105285 1192367 2123931 1936629 2095442 1183093 2381006 8019858 TG(18:1-18:1-20:4) 592761 926184 1089954 1030794 1401266 542969 1350582 1312334 361933 594580 461933 855647 2922407 1718577 750240 1686196 851984 619426 1232252 922058 654583 1508062 1277307 2620788 TG(18:0-18:2-20:4) 8462766 20994910 6261617 32029904 9331083 7008559 21278486 23768288 4596897 11176718 14234068 24243318 56005772 29767450 16294994 19744146 8909587 6548628 41268196 18781294 19515640 28086988 12382550 40633464 TG(16:0-18:0-22:6) 8272057 36870988 13351131 40057780 20689086 13410771 48295664 55882224 8106486 17103686 21680836 55495104 141445520 76302248 36587188 33278896 22865310 19981456 67430536 29883812 38351292 42432324 23973114 86558696 TG(18:1-18:2-20:2) 13728854 57100036 15672377 54030564 23410438 15985064 53023444 55431828 5573047 15506892 23707110 53838068 116337752 84472712 41538888 40883832 20097640 14265345 75058312 27218848 40242896 47507000 23993170 83753016 TG(13:0-18:1-25:4) 8086621 16689335 8008782 22247666 9898335 10414907 17252658 26063018 4675485 9640135 8587717 25684322 41521524 41744796 16893116 21058230 9464435 7984546 29626628 13719296 15715108 17349098 13993466 38291956 TG(18:0-18:1-20:4) 11121159 49730032 21797048 47456892 18374848 15964480 53334928 38143532 4084022 17437964 19533026 54182312 109873592 79028624 35602232 36454276 32502216 18744398 40525036 20736010 22920964 31052262 22286630 80472576 TG(18:0-18:2-20:2) 1571739 5385503 2961418 5105512 3324225 2805748 7635541 5531614 1441616 2512861 3338414 6537102 10237658 8395872 5524996 4554174 3589334 3037008 7377539 4202928 5540686 5734712 4225309 12680441 TG(16:0-18:0-22:4) 2353062 7851298 3261975 6186109 4186493 3590030 8305746 16985964 2281253 4349534 5031052 14036748 31007456 18319790 9001000 5529606 5428597 3960202 16503026 7436280 8345395 8067142 6684336 22862192 TG(18:0-18:0-20:4) 10838474 26235254 8494239 27718334 13956842 16481970 22215148 32506592 4753003 9480004 8660284 35477084 57600668 60137044 15168155 30303616 14342258 10416710 35606008 14216537 18335232 20337142 20814328 45173836 TG(36:2-20:1) 5739884 16129177 8324785 12687848 10023209 10188245 16997664 21367264 2041987 6802296 7926088 21038858 52558924 42559724 17027520 15350760 10591093 10056881 20901518 9235641 10597171 12207440 9827181 37526376 TG(8:0-20:0-28:3) 8763088 35580148 18816296 37312576 16848012 16309991 52025100 44889556 5890801 11780548 17073498 46178740 157674640 88586112 37188972 33959832 28576058 22546158 55746340 26614314 33247790 29777538 27062576 111635760 TG(18:2-18:0-20:0) 6176044 12670892 8277208 24122066 12072663 12486299 25631672 29663374 3732293 6812418 4142983 20846334 51581296 47710332 13126074 19225568 11922633 11554226 23213172 12167825 13075930 11862398 13153628 34769872 TG(22:0-16:1-18:1) 2575138 6325327 4005551 5940053 4102816 3803623 7274100 11696106 1917183 4268981 4386671 10349312 25404994 16466642 8267039 4539214 5120769 3801661 12159055 7316799 6948241 6704181 7017465 21858128 TG(18:0-20:0-18:2) 2869953 9083110 6178942 14928699 6177962 6440748 18413250 21349642 2637360 4816000 5815771 18663834 80496808 34691488 11197161 7477049 7598188 7358691 22785770 11961630 13442923 10264715 12061541 42784980 TG(O-45:1-12:1) 10321070 18431136 10784948 23354694 18101956 15579006 24207072 25371052 7078343 10913213 10125660 29030706 48887024 50044684 17224412 24654256 21978742 19224004 34415420 17807762 18466866 18557346 22607252 32154424 TG(8:0-24:0-24:1) 11036013 26465376 12094245 33565920 17499316 17985862 32303690 42416296 7014350 10908762 9831212 38342248 95490328 87117576 19468710 36565496 18674038 16507418 45415112 20730890 25490652 24168296 27687646 74934624 TG(12:0-22:0-22:0) 7420657 13804303 7538245 17836954 9872268 10570220 14081418 16830206 5014720 6613030 6528322 15212255 37310364 33559152 10749196 15613303 10892465 11025137 22734228 9618308 11119010 11130616 11993015 22313008 TG(14:0-18:0-24:0) 17213960 23927966 11915089 42181360 21818858 20048776 24769680 31628364 8133811 11520699 12545508 34270092 72950720 75434664 22211368 36008204 22920834 20131796 43238476 19218044 23795262 22237170 25638532 54178280 TG(18:2-18:1-22:6) 4913547 7796583 4435490 16406699 7719135 8013457 13537186 15315646 4188762 5692181 5412596 20670924 41280156 29041224 6287469 11612006 7143815 7806090 17983470 9949505 14159025 11272896 15972131 32431770 TG(18:0-18:2-22:6) 187460 166094 187591 228591 376613 369519 1377560 498967 190180 149709 137566 588416 1547134 623544 299470 594445 352378 414934 393358 386953 578385 270172 585595 1252379 TG(18:2-18:0-22:5) 5451350 8869475 4536211 16847748 7631082 8882746 13376939 14169994 4722761 5631599 5764694 17576984 37156604 30848184 8929392 11549019 7354981 9069841 16154313 10037317 11381672 10926026 14089431 30107730 TG(18:1-18:0-22:6) 2492200 2249778 1185314 3038025 1507780 1723506 3121227 1985118 1706411 1424435 2219610 3116768 5503553 3899290 2390202 2187347 1917157 2679262 2383838 2584627 1849434 2525814 2691102 4659682 TG(18:0-18:2-22:4) 1328336 1984986 1345904 3296309 1500493 2676398 5878900 3779328 1653557 1683687 1412514 4543960 8834714 6068816 2397538 2902559 1964957 2182311 3244543 3301044 3435863 3630814 4274104 7746247 TG(16:0-18:1-24:4) 6464739 31578090 8715743 28394738 15192497 9842932 34002308 26193704 4361485 7440105 11760568 30333112 74167328 55615860 25938268 26555690 15810245 11639933 48180424 17108248 19198266 24087360 11662620 36825232 TG(16:2-20:1-22:1) 6777884 24995338 15658400 29907950 18126250 9877811 42076060 40384028 5553146 13312855 15154899 45663716 102011104 57163044 22683232 27338898 19521206 16104479 48839180 22184858 25169954 29716496 20184970 68843296 TG(14:0-22:0-22:4) 625263 1968496 953828 1552529 1200659 1059446 1946794 2856572 520686 951453 1178399 2440869 4558729 3705402 1819319 1743094 1590833 1048754 3431628 1335840 1817667 1743667 1443592 3726393 TG(18:0-20:0-20:4) 2810489 11847156 5572503 9510523 6568423 5611909 13789755 9221860 1880568 3347974 5450096 13877123 49060504 21694262 14636496 8303073 4830644 5854075 19686598 7429087 9778358 11005050 8548819 33853800 TG(40:1-18:2) 2106457 6347834 2333565 7365562 5007608 4404760 7956509 8233783 995202 2653090 2289199 9301624 16685587 22384926 5488706 8054832 4319048 4094223 9594395 4006443 5833349 5546316 6574784 15796002 TG(22:0-18:1-18:2) 2538344 8475295 3695782 9325679 4743631 4585514 8673525 11394258 1607804 2928921 3120136 9808264 30231458 21669298 6408721 10591123 5241120 4837729 13210529 5035659 7721616 5753312 7016090 18487114 TG(24:0-16:1-18:1) 511366 1688010 1489644 2072382 614785 1033637 1743973 3266392 572824 1060633 980065 2474990 7119900 4011092 1730821 780225 1513705 1646683 2687443 1613986 2241664 1976398 1948183 5326260 TG(16:0-24:0-18:2) 1194805 1284372 1560036 3512236 1711534 2094783 2558000 3991572 1027750 1096374 1036508 4193062 11760174 5523680 2105628 1530413 1709874 1559251 3885561 2643231 3049623 2097746 2282896 5792692 TG(16:0-24:0-18:1) 2166180 4241430 2171453 6225229 2969055 3491134 3622874 6787194 1119476 1977675 1905437 5855407 10494263 10402279 3078613 5639310 3063697 3538565 6246205 3302359 3389515 4542322 4012966 7093182 TG(16:0-18:0-24:0) 1977284 4007732 1895451 5925234 3827605 3574931 4151920 6148198 1307591 1745377 2434779 6970779 13795886 10758323 2727118 5519195 2865046 2329662 7799596 3366687 4648133 4492055 5751566 12437391 TG(20:4-20:4-20:4) 3523552 6421683 3748023 8971040 5631084 5250273 7696895 9258181 2227109 3586348 3787388 8991802 19719646 17853500 5438786 8202974 5583212 5503520 10476167 5119424 6196895 6297830 7738783 16902412 TG(18:1-20:4-22:6) 3008207 5396298 3013224 8734745 4961810 5744726 8839965 10075899 2496303 3301448 3642489 10124448 23502884 18327790 5397565 7451696 4992400 4630807 8807448 6399638 8168935 7461557 9658805 19090630 TG(20:4-18:1-22:6) 769264 956590 864168 1862246 1173431 1423066 3613909 1733872 849990 833257 1005662 2160821 4615599 3002360 1434737 1552848 1363837 1494907 1360470 1735648 1703242 2080812 2642858 4728043 TG(38:5-22:6) 2841219 11361656 2931643 14073455 7847985 3055568 13048673 10304918 1801140 4568498 6136406 11903196 20056992 16514636 9280060 9476984 5301379 3579941 21709934 7693293 8790648 10810487 4715703 16954084 TG(16:2-22:4-22:4) 1184784 5819489 2449514 4115456 3148056 1968831 6621989 5618689 833914 2595856 3190793 5766190 12532595 7927147 5208428 4844934 3620559 2702174 8897627 3477940 4457061 4828902 2221457 10427159 TG(18:0-20:4-22:6) 33173 399896 247697 303468 287149 168399 583125 527799 78743 158587 255266 546672 1069394 820131 353907 360035 278982 239843 699330 257303 407918 260579 142329 903238 TG(18:2-18:2-24:4) 996841 3468184 2292053 3931014 2699423 1731656 5900209 4735898 916757 2002535 2369224 5724703 10248853 6645166 3393895 3855021 2728617 2625307 6393110 3143775 3736843 4238286 3031515 8365824 TG(18:0-20:4-22:4) 548248 3756045 1309266 2220808 1649542 800626 3542890 4715204 463560 1294445 1557874 3551860 9415317 6277759 3466150 2105577 1933882 1226694 4095388 1877248 2667800 2079658 1546195 6235875 TG(18:1-20:1-22:5) 953269 4686941 2980653 4376938 2758978 1419958 7826364 7948611 843090 2380724 3085359 7724892 19027058 12834802 5312206 4942916 4684383 3655923 10561915 3248979 5131769 4941268 3257700 13968943 TG(24:3-18:0-18:2) 1459559 8044144 4467270 8206584 4789160 3357499 10724630 9039615 1510614 3589198 3829349 11512332 22398870 14464582 5965583 6912115 4458196 4346171 10304216 5347781 5314840 7104786 5909045 18423654 TG(14:0-16:1-18:2) 842926 5374898 4637706 4279505 3405284 2317269 9306045 5496891 784524 2420232 2906882 5635341 18666034 11215897 4405059 4713961 4453445 4332673 7918537 3416086 4347260 3825765 3607004 13040490 TG(40:1-20:4) 299708 1548809 1127521 1973428 737574 935262 2900165 2328098 224686 677619 398898 2864730 6260485 4841999 1270683 1739443 1206268 915289 2901759 1260976 2230743 1150824 1452276 5389889 TG(12:1-24:1-24:2) 2250537 2873379 2330323 6031072 3763949 2701990 2998020 7113257 2106226 2947628 2781066 4696163 10277867 7179705 4870725 3642546 2894592 2622490 6236014 3328138 4391779 3587393 4606128 7204680 TG(24:0-18:2-18:2) 3040065 6292899 3473957 8078368 7296219 4269681 7247410 8638083 1502359 2769602 3012040 8146369 17336866 14464422 5379874 8947315 6438453 4388252 9627624 4340697 6203888 4910564 6748543 15730286 TG(18:0-24:1-18:2) 502489 979947 753108 1559901 1316316 1020724 1727607 1024459 335256 634151 977648 2583920 2704671 2776223 701413 2112699 830845 988272 2468813 1005460 716828 1418189 1064742 4155642 TG(24:0-18:1-18:1) 1537868 3261991 1655195 4397387 3834044 3215349 4142434 6317438 1264916 2142947 1825162 5940120 10477564 8824481 2634105 5029789 3037217 2650612 6016995 3228267 4169310 3629024 5444753 11080196 TG(18:0-24:0-18:2) 871836 2018651 1068471 2152245 2044874 1651875 2137637 2613423 719583 1036748 857507 2401288 7089053 6335625 1835720 3355398 1594432 1200478 2807273 1613163 1972407 1538321 2694182 4629191 TG(18:0-24:0-18:1) 1279684 2004273 1441640 4167331 1917712 2166046 4518360 4135704 1374758 1663263 1209809 4846694 8996775 7067555 2316640 2998482 2034952 2045067 4603997 3658943 4058729 3180535 4922483 9334009 TG(20:4-20:4-22:6) 978145 2406556 1447147 3416075 2240813 2183137 3849463 3924440 1079388 1343147 1542516 4524840 10683543 7570193 2579011 3039482 1939401 2220415 4235737 2718291 3146637 3449476 4846053 9555501 TG(20:4-20:4-22:4) 440940 2073496 990646 2046191 1764193 871328 3459540 2782868 518132 1203858 1867443 3500693 4157863 4730317 2376214 2449653 1747641 1242418 4950776 1827429 2450622 2671749 808170 4363717 TG(20:2-20:4-22:4) 498215 2999253 1797334 2598791 2184284 1210603 5518651 2790466 360636 1180079 1994482 3347581 6432174 4871789 3474237 2473595 2354611 1514266 4878449 1793140 2268954 2224920 1446434 7491298 TG(18:2-16:0-14:1) 482121 2622669 1362601 2365580 1518036 1068529 3328590 3109215 389152 1205505 1242764 3488777 7511281 5929421 3217073 2247201 1986418 1384041 4488424 1709566 2047410 1901150 1658728 7109245 TG(55:1-6:0) 2142425 2825077 2251813 5810436 3724129 2751439 3150174 7426202 2108898 3048302 2682899 4602158 10150789 7074597 4960745 3829962 2954714 2349361 6217160 3464507 4319762 3668068 4423731 7091235 TG(26:1-18:1-18:1) 814627 1205998 684309 2674104 1170549 1231281 1692296 1945302 745635 837536 796915 2557361 5175935 4089649 1098533 1712584 1191192 1328871 2389199 1560109 1469859 1447535 1682556 3865364 TG(20:0-24:0-18:2) 114118 420044 235888 436565 608548 415632 709378 782315 239075 386331 162986 553890 1467247 1309962 387632 908436 529495 413310 707182 552040 503243 428581 848150 1255173 TG(15:0-16:0-16:0) 259541 459792 394354 997453 533139 595201 1214117 705032 259353 442171 331775 931009 1959519 1671780 363389 844239 496806 505589 956912 769259 1077445 748339 1261972 2243341 TG(18:2-16:0-16:3) 4656176 4641811 4613110 4873889 4474793 4473574 5746403 5887388 4361528 4701807 5108033 4735499 8328832 5638710 3891731 4950076 4625072 3912192 7645215 4617397 4945341 5055355 5288605 5941796 TG(16:1-18:2-22:6) 557518 1008746 494255 1552525 1021731 612035 868404 2311076 464286 670774 730507 1748545 2926582 2116361 1110511 1022111 615835 391330 2470501 1003220 1088567 1253139 1350586 2811658 TG(40:9-16:0) 302037 917795 380387 1314730 568558 334413 1319997 1993926 320259 728205 1083067 1614405 4439949 1766101 1269785 927374 560141 387045 2737156 926462 1387061 1635672 804130 2845225 TG(O-16:0-20:4-20:4) 616150 1497774 785465 1261777 910103 724639 1031991 3604405 851795 1034099 1214265 2670907 4388775 2739109 2481591 1326669 1371151 1078592 2519095 1492064 2286072 1780530 1327742 3346927 TG(O-16:0-18:2-22:4) 836583 3683368 2198071 2812481 2493745 1810107 9098740 5880345 739432 1474190 2098009 6220162 16475955 7699940 3531431 3481449 2982597 2495859 5494209 3188361 4737475 2863242 3922319 14505760 TG(O-18:0-18:1-22:4) 195731 1320862 1564261 1527236 1109938 889183 5969370 1975583 110749 598738 680723 2076044 9207860 4358939 1549013 1580554 2142408 1391929 1905915 1012451 1825610 1363981 1241687 3991127 TG(32:2-27:1) 389175 1189162 1079045 1186516 815788 874853 1854512 1753437 226239 466967 678658 1508712 3658267 3206918 1831634 708218 1345961 928819 1767098 1039989 1378988 739923 1458651 3650758 TG(18:0-20:4-22:5) 7160783 12952285 7873536 16329120 14296436 10037174 16669628 16694847 4858314 8532373 8176936 20432150 32392112 38090696 14266744 19480042 14757098 12082804 23306558 10150810 14140695 11873032 15856570 30707938 TG(40:5-22:6) 120877 931786 1064076 797160 805161 582067 2012251 801510 148031 331588 551093 1198466 3731099 2171752 1175508 956599 895415 957846 1708649 814779 950044 903252 636632 3049484 TG(42:8-22:6) 43421 455231 274620 341082 405709 162781 938055 548152 30619 250002 380499 556067 1229232 799216 695490 369206 455498 308390 961087 347450 406914 436216 188468 1133851 TG(15:0-16:1-18:1) 73989200 66520204 80817048 58596644 67285744 47306176 58186392 53990148 69276240 72949216 69006480 82289440 43608912 64027476 60333520 63085292 84672584 44485040 62560448 62700048 55931188 65197584 81763400 64301536 TG(17:0-18:2-18:2) 1813326 1673546 1416459 2130786 1755502 1240136 1522498 1265766 853648 1174763 1010350 2944958 3038972 1648868 1309224 2544073 1774255 829364 1387790 1275841 1266972 2301905 2418925 4675020 TG(O-16:0-18:1-22:6) 1176759 4172930 1965928 3368099 2329309 2126332 6847346 6480886 785599 1525002 2007571 7209925 15928810 10887501 4612330 5102630 3120636 2472268 5538090 3637535 5966934 2623541 4005288 14487686 TG(14:0-16:1-18:1) 16073278 25499352 15425673 38881316 25465222 20506124 24155430 61813064 14934499 20726830 21307262 39014768 82883320 59905080 30194564 28073138 20537748 15925065 44534416 24186698 33266876 28761006 35871128 60655568 TG(30:1-18:0) 1817005 2527357 1011747 2803595 1544505 1233295 1351834 4733449 1361997 2461025 1460687 2357349 5620678 3781266 2610225 2844436 1558824 1844257 3597701 1584261 2339830 1666622 2927196 3578549 TG(14:0-16:0-18:1) 25363060 38488028 23445888 52480340 38977056 25791460 33628992 77098296 23382390 29380514 27344090 62932172 108654096 96442936 49543900 45100600 38822636 27604826 61631588 34347144 44168928 40127116 53794636 94926096 TG(16:0-16:0-16:0) 19144470 31287098 22768122 45918104 31638306 28260244 48339600 84428640 20062670 24644328 29505212 60822592 114288224 80393704 38722964 40635348 34059288 26100224 49110944 39919224 49350944 42801592 46883008 97114096 TG(O-16:0-16:1-18:1) 618561 1094649 796717 1555771 1256778 1105716 2419127 2177201 361637 595026 646428 1632343 4127950 3422963 1418011 2331834 1159009 928536 1903400 1043083 1608461 797611 1548015 3883170 TG(O-16:0-16:0-18:2) 1025148 1515456 1855903 2706670 2728578 1868539 7929097 4072973 900980 1344495 1610111 3757814 9427124 5748476 1633692 3267964 2581620 2004066 3618180 2478487 2925066 1653992 3880082 8140562 TG(15:0-16:0-18:1) 8212150 9408239 8163299 9541894 9479791 8855841 11354011 12296808 6935301 8180298 8516891 12332026 18401614 15070946 10369739 10825073 9641047 9924662 13623543 10115574 9634866 10375222 9999771 16103522 TG(O-16:0-16:0-18:1) 2458378 4374600 3178464 6216320 5653690 4237360 12459960 8410479 1656776 3173289 2871787 8170281 19751826 14875656 5300841 8047363 5484519 4596748 7310605 5240433 7821295 3789173 6716150 18538334 TG(14:0-16:0-16:0) 10529018 16174426 12232820 19067442 14402954 11551928 16923882 24575710 12220922 13914520 13022545 22340266 42155012 33415092 17820060 17490954 15505731 11176845 24838642 15724158 16853952 16410904 22065646 31610768 TG(15:0-16:0-18:0) 2115918 2756831 2072259 2811659 2885501 2533775 3781637 3210560 2166054 2309214 2767742 3399121 5349568 3757943 2784996 2570781 2605696 2465158 3530427 3163021 2651306 2784988 3270841 5079504 TG(O-16:0-16:0-18:0) 1193845 1811387 1475411 3671223 2816319 2649517 8844379 4028961 1340763 1521993 1547195 4968939 13175000 6864111 2910260 3317350 2237236 2409894 3938137 3407291 4770582 2402892 4641902 12305955 TG(16:1-16:1-18:2) 5543069 9669054 5301714 14610167 9322575 6567986 9974416 22991182 4388752 7002089 7660522 16200872 32334438 21511116 10699735 11279814 7256233 5201292 22214452 10048835 12051771 13022506 12102531 28338194 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Cer(d18:2-24:1) Cer(d18:0-24:1) Cer(d18:1-24:0) Cer(d18:1-16:0) Cer(d18:0-24:0) CerPE(16:0-d18:1) Ch() Ch-D7() ChE(20:4) ChE(22:6) ChE(22:4) Co(Q9) Co(Q10) DG(19:2) DG(16:0-18:2) DG(16:0-18:0) DG(18:2-18:2) DG(18:1-18:2) DG(18:0-18:2) DG(18:0-18:0) DG(18:0-20:4) Hex1Cer(d42:2) Hex1Cer(24:0-d18:1) Hex1Cer(16:0-d18:1) LPC(18:2) LPC(18:0) LPC(30:0) LPC(16:0) LPE(18:1) LPE(20:4) PA(O-18:2-18:2) PA(O-20:2-18:2) PA(O-4:0-15:0) PA(24:1-18:1) PC(34:3) PC(34:2) PC(16:0-18:1) PC(34:0) PC(O-36:4) PC(O-36:3) PC(O-36:2) PC(36:4) PC(O-32:1) PC(18:2-18:1) PC(36:2) 1-PC(36:1) 2-PC(36:1) PC(O-38:7) PC(O-38:4) PC(22:7-16:0) PC(38:6) PC(38:5) PC(38:4) PC(20:4-18:0) PC(38:3) PC(38:2) PC(40:8) PC(40:7) PC(40:6) PC(40:5) PC(40:4) PC(31:2) PC(31:0) PC(O-32:0) PC(32:1) PC(16:0-16:0) PC(33:3) PC(O-34:3) PC(30:0) PC(33:2) PC(O-34:2) PC(O-34:1) PC(33:0) PC(O-34:0) PE(P-18:0-20:4) PE(22:6-16:0) PE(20:4-18:0) PE(38:4) PE(P-18:1-22:6) PE(O-40:8) PE(P-18:0-22:6) PE(40:7) PE(22:6-18:0) PE(40:4) PE(34:1) PE(19:1) PE(P-16:0-18:2) PE(P-16:0-18:1) PE(34:2) PE(P-16:0-20:4) PE(P-18:0-18:2) PE(P-18:0-18:1) PE(20:4-16:0) PE(36:2) PE(O-38:8) PE(18:0-18:1) PE(P-16:0-22:6) PI(20:4-18:0) SM(d42:1) SM(d42:0) SM(d44:5) SM(d44:4) SM(t22:1) SM(d34:1) SM(d34:0) SM(d36:4) SM(d36:3) SM(d40:1) SM(d40:0) SM(t40:7) SM(d41:3) SM(d42:3) SM(d42:2) TG(12:0-16:0-18:2) TG(34:2-16:2) TG(16:0-16:1-18:1) TG(32:1-18:0) TG(16:0-18:0-16:1) TG(16:0-16:0-18:0) TG(O-16:0-16:0-20:4) TG(15:0-18:1-18:2) TG(O-18:1-16:0-18:2) TG(O-18:1-14:0-16:0) TG(16:0-17:1-18:1) TG(O-16:0-18:0-18:2) TG(16:0-17:0-18:1) TG(O-16:1-18:0-18:0) TG(O-18:0-16:0-18:1) TG(16:0-17:0-18:0) TG(O-18:0-16:0-18:0) TG(14:0-18:2-20:4) TG(16:0-18:2-18:3) TG(16:0-16:1-20:4) TG(16:1-18:1-18:2) TG(16:1-18:1-18:1) TG(16:0-18:1-18:2) TG(16:0-18:1-18:1) TG(16:0-18:0-18:2) TG(20:0-18:0-14:1) TG(14:0-19:0-19:0) TG(16:0-18:0-18:0) TG(O-32:0-22:6) TG(O-16:0-18:1-20:4) TG(O-36:3-18:1) TG(O-16:0-18:0-20:4) TG(O-18:0-18:1-18:2) TG(O-18:0-16:0-20:3) TG(17:0-18:1-18:1) TG(O-20:0-16:0-18:2) TG(18:2-14:0-22:6) TG(17:0-18:0-18:1) TG(O-20:0-16:0-18:1) TG(18:2-16:0-20:5) TG(16:1-18:2-20:3) TG(16:0-18:2-20:4) TG(16:0-16:0-22:6) TG(18:1-18:2-18:2) TG(16:0-18:1-20:4) TG(20:4-16:0-18:1) TG(18:0-18:2-18:2) TG(O-18:0-14:0-16:0) TG(16:0-18:0-20:4) TG(18:2-18:0-18:1) TG(18:0-18:1-18:2) TG(36:2-18:0) TG(16:0-18:1-20:1) TG(18:0-18:0-18:2) TG(16:0-18:0-20:1) TG(16:0-18:0-20:0) TG(O-18:0-18:1-20:4) TG(O-16:0-18:0-22:4) TG(37:1-18:2) TG(18:2-18:2-20:4) TG(16:0-18:2-22:6) TG(18:1-18:2-20:4) TG(18:1-18:2-20:3) TG(18:1-18:1-20:4) TG(18:0-18:2-20:4) TG(16:0-18:0-22:6) TG(18:1-18:2-20:2) TG(13:0-18:1-25:4) TG(18:0-18:1-20:4) TG(18:0-18:2-20:2) TG(16:0-18:0-22:4) TG(18:0-18:0-20:4) TG(36:2-20:1) TG(8:0-20:0-28:3) TG(18:2-18:0-20:0) TG(22:0-16:1-18:1) TG(18:0-20:0-18:2) TG(O-45:1-12:1) TG(8:0-24:0-24:1) TG(12:0-22:0-22:0) TG(14:0-18:0-24:0) TG(18:2-18:1-22:6) TG(18:0-18:2-22:6) TG(18:2-18:0-22:5) TG(18:1-18:0-22:6) TG(18:0-18:2-22:4) TG(16:0-18:1-24:4) TG(16:2-20:1-22:1) TG(14:0-22:0-22:4) TG(18:0-20:0-20:4) TG(40:1-18:2) TG(22:0-18:1-18:2) TG(24:0-16:1-18:1) TG(16:0-24:0-18:2) TG(16:0-24:0-18:1) TG(16:0-18:0-24:0) TG(20:4-20:4-20:4) TG(18:1-20:4-22:6) TG(20:4-18:1-22:6) TG(38:5-22:6) TG(16:2-22:4-22:4) TG(18:0-20:4-22:6) TG(18:2-18:2-24:4) TG(18:0-20:4-22:4) TG(18:1-20:1-22:5) TG(24:3-18:0-18:2) TG(14:0-16:1-18:2) TG(40:1-20:4) TG(12:1-24:1-24:2) TG(24:0-18:2-18:2) TG(18:0-24:1-18:2) TG(24:0-18:1-18:1) TG(18:0-24:0-18:2) TG(18:0-24:0-18:1) TG(20:4-20:4-22:6) TG(20:4-20:4-22:4) TG(20:2-20:4-22:4) TG(18:2-16:0-14:1) TG(55:1-6:0) TG(26:1-18:1-18:1) TG(20:0-24:0-18:2) TG(15:0-16:0-16:0) TG(18:2-16:0-16:3) TG(16:1-18:2-22:6) TG(40:9-16:0) TG(O-16:0-20:4-20:4) TG(O-16:0-18:2-22:4) TG(O-18:0-18:1-22:4) TG(32:2-27:1) TG(18:0-20:4-22:5) TG(40:5-22:6) TG(42:8-22:6) TG(15:0-16:1-18:1) TG(17:0-18:2-18:2) TG(O-16:0-18:1-22:6) TG(14:0-16:1-18:1) TG(30:1-18:0) TG(14:0-16:0-18:1) TG(16:0-16:0-16:0) TG(O-16:0-16:1-18:1) TG(O-16:0-16:0-18:2) TG(15:0-16:0-18:1) TG(O-16:0-16:0-18:1) TG(14:0-16:0-16:0) TG(15:0-16:0-18:0) TG(O-16:0-16:0-18:0) TG(16:1-16:1-18:2) METABOLITES_END #END