#METABOLOMICS WORKBENCH siokatgs_20250219_072847 DATATRACK_ID:5648 STUDY_ID:ST003743 ANALYSIS_ID:AN006147 PROJECT_ID:PR002329 VERSION 1 CREATED_ON February 19, 2025, 2:07 pm #PROJECT PR:PROJECT_TITLE Hepato-cardiac interorgan communication controls cardiac hypertrophy via PR:PROJECT_TITLE combined endocrine-autocrine FGF21 signaling. PR:PROJECT_SUMMARY Fibroblast Growth Factor (FGF) 21 is a hormone produced mainly by the liver but PR:PROJECT_SUMMARY also other organs, including the heart. Although FGF21 analogs are used for PR:PROJECT_SUMMARY treating obesity and metabolic syndrome in humans, preclinical and clinical PR:PROJECT_SUMMARY studies have elicited mixed results about whether prolonged FGF21 signaling is PR:PROJECT_SUMMARY protective or detrimental for cardiac function. Based on our findings, showing PR:PROJECT_SUMMARY elevated serum and cardiac FGF21 levels in humans with increased left PR:PROJECT_SUMMARY ventricular afterload, we explored involvement of FGF21 in cardiac hypertrophy. PR:PROJECT_SUMMARY Our mouse studies revealed an interorgan liver-heart crosstalk mechanism which PR:PROJECT_SUMMARY is controlled by initial hepatic FGF21 release followed by induction of PR:PROJECT_SUMMARY cardiomyocyte FGF21 expression. Tissue-specific genetic ablation or anti-sense PR:PROJECT_SUMMARY oligonucleotides-based inhibition of FGF21 showed that in response to pressure PR:PROJECT_SUMMARY overload, cardiomyocyte FGF21 upregulation is a critical event that is PR:PROJECT_SUMMARY stimulated by liver-derived FGF21 and drives cardiac hypertrophy likely by PR:PROJECT_SUMMARY interfering with cardioprotective oxytocin signaling. Conclusively, a PR:PROJECT_SUMMARY hepato-cardiac FGF21-based signaling axis governs cardiac hypertrophy. PR:INSTITUTE University of Cincinnati College of Medicine PR:LAST_NAME Siokatas PR:FIRST_NAME Georgios PR:ADDRESS 231 ALBERT SABIN WAY, University of Cincinnati, Cincinnati, OH, 45267-2827 PR:EMAIL siokatgs@ucmail.uc.edu PR:PHONE 5133028282 #STUDY ST:STUDY_TITLE Hepato-cardiac interorgan communication controls cardiac hypertrophy via ST:STUDY_TITLE combined endocrine-autocrine FGF21 signaling. ST:STUDY_SUMMARY Fibroblast Growth Factor (FGF) 21 is a hormone produced mainly by the liver but ST:STUDY_SUMMARY also other organs, including the heart. Although FGF21 analogs are used for ST:STUDY_SUMMARY treating obesity and metabolic syndrome in humans, preclinical and clinical ST:STUDY_SUMMARY studies have elicited mixed results about whether prolonged FGF21 signaling is ST:STUDY_SUMMARY protective or detrimental for cardiac function. Based on our findings, showing ST:STUDY_SUMMARY elevated serum and cardiac FGF21 levels in humans with increased left ST:STUDY_SUMMARY ventricular afterload, we explored involvement of FGF21 in cardiac hypertrophy. ST:STUDY_SUMMARY Our mouse studies revealed an interorgan liver-heart crosstalk mechanism which ST:STUDY_SUMMARY is controlled by initial hepatic FGF21 release followed by induction of ST:STUDY_SUMMARY cardiomyocyte FGF21 expression. Tissue-specific genetic ablation or anti-sense ST:STUDY_SUMMARY oligonucleotides-based inhibition of FGF21 showed that in response to pressure ST:STUDY_SUMMARY overload, cardiomyocyte FGF21 upregulation is a critical event that is ST:STUDY_SUMMARY stimulated by liver-derived FGF21 and drives cardiac hypertrophy likely by ST:STUDY_SUMMARY interfering with cardioprotective oxytocin signaling. Conclusively, a ST:STUDY_SUMMARY hepato-cardiac FGF21-based signaling axis governs cardiac hypertrophy. ST:INSTITUTE University of Cincinnati College of Medicine ST:LAST_NAME Siokatas ST:FIRST_NAME Georgios ST:ADDRESS 231 ALBERT SABIN WAY, University of Cincinnati, Cincinnati, OH, 45267-2827 ST:EMAIL siokatgs@ucmail.uc.edu ST:PHONE 5133028282 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS H-5466 FGF-H01 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=Sham; weight (g)=0.026; RAW_FILE_NAME(raw file name)=FGF-H01 SUBJECT_SAMPLE_FACTORS H-5467 FGF-H02 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=Sham; weight (g)=0.029; RAW_FILE_NAME(raw file name)=FGF-H02 SUBJECT_SAMPLE_FACTORS H-5468 FGF-H03 Sample source:Heart | Genotype:- | Timepoint:Fgf21 fl/fl Surgery=3 Days; weight (g)=Sham; RAW_FILE_NAME(raw file name)=0.02 SUBJECT_SAMPLE_FACTORS H-3881 FGF-H04 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=Sham; weight (g)=0.033; RAW_FILE_NAME(raw file name)=FGF-H04 SUBJECT_SAMPLE_FACTORS H-3916 FGF-H05 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=Sham; weight (g)=0.021; RAW_FILE_NAME(raw file name)=FGF-H05 SUBJECT_SAMPLE_FACTORS H-8 FGF-H06 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=TAC; weight (g)=0.021; RAW_FILE_NAME(raw file name)=FGF-H06 SUBJECT_SAMPLE_FACTORS H-9 FGF-H07 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=TAC; weight (g)=0.035; RAW_FILE_NAME(raw file name)=FGF-H07 SUBJECT_SAMPLE_FACTORS H-10 FGF-H08 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=TAC; weight (g)=0.041; RAW_FILE_NAME(raw file name)=FGF-H08 SUBJECT_SAMPLE_FACTORS H-3 FGF-H09 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=TAC; weight (g)=0.028; RAW_FILE_NAME(raw file name)=FGF-H09 SUBJECT_SAMPLE_FACTORS H-6 FGF-H10 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Surgery=TAC; weight (g)=0.021; RAW_FILE_NAME(raw file name)=FGF-H10 SUBJECT_SAMPLE_FACTORS H-5469 FGF-H11 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=Sham; weight (g)=0.022; RAW_FILE_NAME(raw file name)=FGF-H11 SUBJECT_SAMPLE_FACTORS H-5470 FGF-H12 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=Sham; weight (g)=0.038; RAW_FILE_NAME(raw file name)=FGF-H12 SUBJECT_SAMPLE_FACTORS H-5471 FGF-H13 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=Sham; weight (g)=0.035; RAW_FILE_NAME(raw file name)=FGF-H13 SUBJECT_SAMPLE_FACTORS H-3919 FGF-H14 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=Sham; weight (g)=0.024; RAW_FILE_NAME(raw file name)=FGF-H14 SUBJECT_SAMPLE_FACTORS H-3951 FGF-H15 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=Sham; weight (g)=0.036; RAW_FILE_NAME(raw file name)=FGF-H15 SUBJECT_SAMPLE_FACTORS H-6888 FGF-H16 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=TAC; weight (g)=0.054; RAW_FILE_NAME(raw file name)=FGF-H16 SUBJECT_SAMPLE_FACTORS H-6889 FGF-H17 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=TAC; weight (g)=0.045; RAW_FILE_NAME(raw file name)=FGF-H17 SUBJECT_SAMPLE_FACTORS H-6890 FGF-H18 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=TAC; weight (g)=0.061; RAW_FILE_NAME(raw file name)=FGF-H18 SUBJECT_SAMPLE_FACTORS H-6905 FGF-H19 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=TAC; weight (g)=0.037; RAW_FILE_NAME(raw file name)=FGF-H19 SUBJECT_SAMPLE_FACTORS H-6891 FGF-H20 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Surgery=TAC; weight (g)=0.043; RAW_FILE_NAME(raw file name)=FGF-H20 SUBJECT_SAMPLE_FACTORS 7367 FGF-H21 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=Sham; weight (g)=0.022; RAW_FILE_NAME(raw file name)=FGF-H21 SUBJECT_SAMPLE_FACTORS 7313 FGF-H22 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=Sham; weight (g)=0.022; RAW_FILE_NAME(raw file name)=FGF-H22 SUBJECT_SAMPLE_FACTORS 7370 FGF-H23 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=Sham; weight (g)=0.012; RAW_FILE_NAME(raw file name)=FGF-H23 SUBJECT_SAMPLE_FACTORS 7368 FGF-H24 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=Sham; weight (g)=0.023; RAW_FILE_NAME(raw file name)=FGF-H24 SUBJECT_SAMPLE_FACTORS 753 FGF-H25 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=Sham; weight (g)=0.022; RAW_FILE_NAME(raw file name)=FGF-H25 SUBJECT_SAMPLE_FACTORS 7680 FGF-H26 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.028; RAW_FILE_NAME(raw file name)=FGF-H26 SUBJECT_SAMPLE_FACTORS 7682 FGF-H27 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.035; RAW_FILE_NAME(raw file name)=FGF-H27 SUBJECT_SAMPLE_FACTORS 7828 FGF-H28 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.029; RAW_FILE_NAME(raw file name)=FGF-H28 SUBJECT_SAMPLE_FACTORS 7829 FGF-H29 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.031; RAW_FILE_NAME(raw file name)=FGF-H29 SUBJECT_SAMPLE_FACTORS 7161 FGF-H30 Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.024; RAW_FILE_NAME(raw file name)=FGF-H30 SUBJECT_SAMPLE_FACTORS 6357 FGF-H31 Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.026; RAW_FILE_NAME(raw file name)=FGF-H31 SUBJECT_SAMPLE_FACTORS 5814 FGF-H32 Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.034; RAW_FILE_NAME(raw file name)=FGF-H32 SUBJECT_SAMPLE_FACTORS 6077 FGF-H33 Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.021; RAW_FILE_NAME(raw file name)=FGF-H33 SUBJECT_SAMPLE_FACTORS 5974 FGF-H34 Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.021; RAW_FILE_NAME(raw file name)=FGF-H34 SUBJECT_SAMPLE_FACTORS 6188 FGF-H35 Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.02; RAW_FILE_NAME(raw file name)=FGF-H35 SUBJECT_SAMPLE_FACTORS 6534 FGF-H36 Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.011; RAW_FILE_NAME(raw file name)=FGF-H36 SUBJECT_SAMPLE_FACTORS 6537 FGF-H37 Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.022; RAW_FILE_NAME(raw file name)=FGF-H37 SUBJECT_SAMPLE_FACTORS 6538 FGF-H38 Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.025; RAW_FILE_NAME(raw file name)=FGF-H38 SUBJECT_SAMPLE_FACTORS 6282 FGF-H39 Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.012; RAW_FILE_NAME(raw file name)=FGF-H39 SUBJECT_SAMPLE_FACTORS 7221 FGF-H40 Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Surgery=TAC; weight (g)=0.026; RAW_FILE_NAME(raw file name)=FGF-H40 #COLLECTION CO:COLLECTION_SUMMARY Collection and Storage: Hearts were perfused with ice-cold PBS, carefully CO:COLLECTION_SUMMARY dissected, and snap-frozen in liquid nitrogen. All samples were stored at -80°C CO:COLLECTION_SUMMARY until further processing. CO:SAMPLE_TYPE Heart #TREATMENT TR:TREATMENT_SUMMARY Mice underwent Sham or TAC (Transverse Aortic Constriction) surgery. A TR:TREATMENT_SUMMARY thoracotomy was performed, and the transverse aorta was isolated and tied around TR:TREATMENT_SUMMARY 27-gauge needle, which was removed to generate the desired constriction. The TR:TREATMENT_SUMMARY incision to the rib cage was closed using a 6.0 silk suture (AD Surgical) and TR:TREATMENT_SUMMARY the skin wound was closed with a 5.0 silk suture. (AD Surgical). The sham TR:TREATMENT_SUMMARY procedure was identical except that aortic arch was not constricted. Tissues TR:TREATMENT_SUMMARY were collected 3 days, 2 weeks or 8 weeks post-surgery. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Each individual sample was homogenized using a cryogenic ball-mill homogenizer SP:SAMPLEPREP_SUMMARY (Cryomill, Retsch Inc.) and weighted into bead tubes (2.8 mm, MO BIO, catalog SP:SAMPLEPREP_SUMMARY #13114-50) for extraction. Based on the weights of tissues, the solvent volumes SP:SAMPLEPREP_SUMMARY used for extraction were calculated for each sample. Modified Bligh and Dyer SP:SAMPLEPREP_SUMMARY extraction1-3 was used to obtain polar metabolites. Briefly, cold methanol and SP:SAMPLEPREP_SUMMARY water were added to the samples in bead tubes and homogenized for 30 s. The SP:SAMPLEPREP_SUMMARY samples were transferred into glass tubes containing cold chloroform and water. SP:SAMPLEPREP_SUMMARY The final methanol:chloroform:water ratio is 2:2:1.8. The mixture was vortexed, SP:SAMPLEPREP_SUMMARY incubated on ice for 10 min, then centrifuged at 2000x gn for 5 min. The polar SP:SAMPLEPREP_SUMMARY phase was transferred into 1.5mL Eppendorf tube and dried by vacuum centrifuge SP:SAMPLEPREP_SUMMARY for 4-5 hrs at room temperature. The dried metabolites were resuspended in 220 SP:SAMPLEPREP_SUMMARY uL of NMR buffer containing 100mM phosphate buffer, pH7.3, 1mM TMSP SP:SAMPLEPREP_SUMMARY (3-Trimethylsilyl 2,2,3,3-d4 propinoate), 1mg/mL sodium azide) prepared in D2O. SP:SAMPLEPREP_SUMMARY Final volume of 200 uL of each sample was transferred into 3 mm NMR tube SP:SAMPLEPREP_SUMMARY (Bruker) for data collection #ANALYSIS AN:ANALYSIS_TYPE NMR #NMR NM:INSTRUMENT_NAME Bruker Avance III NM:INSTRUMENT_TYPE FT-NMR NM:NMR_EXPERIMENT_TYPE 1D-1H NM:FIELD_FREQUENCY_LOCK Detuterium NM:STANDARD_CONCENTRATION 1 mM NM:SPECTROMETER_FREQUENCY 600 MHz NM:NMR_PROBE Prodigy 5mm BBI NM:NMR_SOLVENT D2O NM:NMR_TUBE_SIZE 103.5 mm x 5 mm NM:SHIMMING_METHOD Topshim NM:PULSE_SEQUENCE noesygppr1d #NMR_METABOLITE_DATA NMR_METABOLITE_DATA:UNITS mM NMR_METABOLITE_DATA_START Samples FGF-H01 FGF-H02 FGF-H03 FGF-H04 FGF-H05 FGF-H06 FGF-H07 FGF-H08 FGF-H09 FGF-H10 FGF-H11 FGF-H12 FGF-H13 FGF-H14 FGF-H15 FGF-H16 FGF-H17 FGF-H18 FGF-H19 FGF-H20 FGF-H21 FGF-H22 FGF-H23 FGF-H24 FGF-H25 FGF-H26 FGF-H27 FGF-H28 FGF-H29 FGF-H30 FGF-H31 FGF-H32 FGF-H33 FGF-H34 FGF-H35 FGF-H36 FGF-H37 FGF-H38 FGF-H39 FGF-H40 Factors Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:- | Timepoint:Fgf21 fl/fl Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:3 Days Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:2 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:Fgf21 fl/fl | Timepoint:8 Weeks Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:αMHC-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks Sample source:Heart | Genotype:Alb-Cre Fgf21-/- | Timepoint:8 Weeks 3-Hydroxybutyrate 0.032307692 0.028965517 0.03 0.027272727 0.077142857 0.065714286 0.065142857 0.043902439 0.100714286 0.051428571 0.03 0.022105263 0.041142857 0.14 0.121666667 0.073333333 0.116 0.072786885 0.092432432 0.080930233 0.02727 0.02182 0.03000 0.02087 0.02455 0.05571 0.02229 0.02690 0.06581 0.05750 0.036923077 0.015882353 0.062857143 0.037142857 0.033 0.043636364 0.019090909 0.0312 0.05 0.013846154 ADP 1.089230769 1.189655172 1.542 0.867272727 0.782857143 0.831428571 1.253142857 0.725853659 0.820714286 0.637142857 1.197272727 0.934736842 1.004571429 0.3175 0.28 0.887777778 0.825333333 0.888196721 0.874054054 0.823255814 1.20818 1.34455 1.28000 1.44261 1.23818 1.40786 1.05600 1.40483 1.29290 1.23750 1.073076923 1.155882353 0.828571429 1.114285714 1.686 1.374545455 1.666363636 1.7568 2.035 1.073076923 AMP 3.724615385 3.833793103 2.784 4.290909091 4.3 2.108571429 2.269714286 2.086829268 2.089285714 2.237142857 3.166363636 2.34 3.001714286 2.1875 1.613333333 2.572222222 2.322666667 2.350819672 2.654594595 2.193488372 3.42545 3.59455 3.77500 3.33913 2.68091 3.16714 2.67257 3.03931 3.24387 3.66250 2.709230769 2.687647059 2.437142857 2.417142857 3.432 3.278181818 3.002727273 2.8776 3.105 2.570769231 ATP 1.804615385 1.377931034 2.34 0.301818182 0.22 1.822857143 0.905142857 1.211707317 1.000714286 1.168571429 1.420909091 1.354736842 1.093714286 0.105 0.116666667 0.896666667 1.112 1.02 0.765405405 1.160930233 1.53273 1.46455 2.15000 1.56522 1.17273 1.04786 0.99600 1.42552 1.17097 0.98250 1.017692308 1.692352941 0.808571429 0.625714286 1.482 2.056363636 1.838181818 1.3704 1.86 1.172307692 Acetate 0.166153846 0.128275862 0.207 0.109090909 0.222857143 0.214285714 0.135428571 0.093658537 0.145714286 0.194285714 0.220909091 0.108947368 0.157714286 0.195 0.128333333 0.098888889 0.104 0.074754098 0.098918919 0.111627907 0.15000 0.13364 0.15500 0.12000 0.13364 0.09000 0.09429 0.09103 0.07742 0.12750 0.122307692 0.084705882 0.085714286 0.122857143 0.168 0.163636364 0.12 0.0936 0.185 0.106153846 Alanine 2.441538462 1.992413793 2.379 2.443636364 2.191428571 2.385714286 2.458285714 1.833658537 3.250714286 2.234285714 2.536363636 1.678421053 2.178857143 2.185 1.921666667 2.575555556 2.266666667 2.350819672 2.28 2.934418605 1.33091 0.92727 1.43500 1.01217 1.03364 1.93714 1.06800 1.44000 1.83677 1.92500 1.71 1.985294118 2.011428571 1.657142857 2.727 2.852727273 1.865454545 2.1168 3.01 0.849230769 Asparagine 0.242307692 0.128275862 0.216 0.287272727 0.202857143 0.16 0.222857143 0.219512195 0.321428571 0.154285714 0.147272727 0.132631579 0.212571429 0.1975 0.118333333 0.743333333 0.212 0.230163934 0.222162162 0.255348837 0.14727 0.14455 0.20000 0.16957 0.15818 0.25071 0.17829 0.31241 0.29226 0.27750 0.297692308 0.229411765 0.262857143 0.317142857 0.309 0.343636364 0.21 0.264 0.365 0.15 Aspartate 1.386923077 1.24137931 1.41 1.545454545 1.277142857 1.237142857 1.568571429 1.094634146 2.237142857 1.38 1.126363636 0.753157895 0.855428571 0.8525 0.945 2.635555556 1.622666667 1.870819672 1.138378378 1.258604651 0.52909 0.80727 0.89500 0.87652 0.93545 1.16143 0.52457 1.15862 1.74194 1.30250 3.094615385 1.424117647 1.602857143 2 2.121 2.683636364 1.666363636 1.5264 2.26 0.703846154 Choline 0.087692308 0.099310345 0.108 0.105454545 0.14 0.051428571 0.073714286 0.052682927 0.070714286 0.068571429 0.106363636 0.091578947 0.085714286 0.135 0.105 0.088888889 0.057333333 0.048196721 0.087567568 0.054418605 0.06273 0.10091 0.09000 0.06261 0.09545 0.08143 0.07029 0.06207 0.07355 0.07750 0.066923077 0.074117647 0.048571429 0.071428571 0.096 0.081818182 0.087272727 0.0672 0.075 0.053076923 Citrate 0.747692308 0.866896552 0.783 0.636363636 0.642857143 0.371428571 0.430285714 0.342439024 0.694285714 0.434285714 0.867272727 0.836842105 0.793714286 0.435 0.36 0.401111111 0.410666667 0.384590164 0.322702703 0.470232558 0.69000 0.63818 0.38500 0.62870 0.58909 0.72643 0.32229 0.47586 0.60000 0.60000 0.521538462 0.705882353 0.388571429 0.671428571 0.717 0.932727273 0.957272727 0.9408 1.115 0.526153846 Creatine 14.70230769 14.26137931 13.722 13.44363636 13.39142857 10.02 10.15028571 8.357560976 6.57 8.365714286 12.90545455 9.737368421 12.32228571 8.7475 5.71 9.261111111 10.296 9.02557377 9.809189189 8.967906977 12.64364 12.67091 14.85500 14.21739 11.25545 12.63214 11.10171 11.49724 12.22452 12.20500 9.616153846 12.03 9.251428571 8.557142857 13.302 16.46181818 13.77545455 13.4904 14.735 10.68 Creatine phosphate 0.297692308 0.403448276 0.318 0.121818182 0.054285714 0.1 0.125142857 0.232682927 0.203571429 0.122857143 0.286363636 0.317368421 0.291428571 0.12 0.038333333 0.158888889 0.297333333 0.219344262 0.186486486 0.241395349 0.19091 0.02455 0.13500 0.27913 0.18273 0.16071 0.22114 0.21931 0.19935 0.14000 0.152307692 0.257647059 0.108571429 0.074285714 0.213 0.185454545 0.343636364 0.1704 0.17 0.258461538 Creatinine 0.154615385 0.10137931 0.024 0.14 0.108571429 0.108571429 0.084 0.07902439 0.12 0.082857143 0.122727273 0.093157895 0.128571429 0.1025 0.08 0.091111111 0.090666667 0.097377049 0.085945946 0.076744186 0.14455 0.14182 0.14500 0.14609 0.07909 0.13286 0.12000 0.13448 0.12387 0.13250 0.106153846 0.105882353 0.105714286 0.091428571 0.168 0.185454545 0.158181818 0.0984 0.16 0.101538462 Formate 0.115384615 0.084827586 0.111 0.081818182 0.105714286 0.102857143 0.077142857 0.061463415 0.107142857 0.08 0.106363636 0.058421053 0.082285714 0.0925 0.058333333 0.053333333 0.069333333 0.051147541 0.056756757 0.054418605 0.09000 0.09000 0.15000 0.07043 0.07909 0.07929 0.07029 0.07448 0.07161 0.09750 0.053076923 0.033529412 0.077142857 0.065714286 0.078 0.065454545 0.057272727 0.0504 0.1 0.064615385 Fumarate 0.256153846 0.200689655 0.282 0.203636364 0.168571429 0.162857143 0.164571429 0.136097561 0.201428571 0.185714286 0.21 0.126315789 0.152571429 0.135 0.085 0.154444444 0.176 0.167213115 0.141081081 0.160465116 0.11455 0.13364 0.08000 0.09913 0.08455 0.11143 0.05657 0.08276 0.11032 0.11000 0.154615385 0.130588235 0.125714286 0.108571429 0.204 0.207272727 0.158181818 0.1776 0.215 0.083076923 GTP 0.117692308 0.105517241 0.111 0.116363636 0.08 0.08 0.097714286 0.090731707 0.115714286 0.094285714 0.111818182 0.09 0.097714286 0.095 0.053333333 0.096666667 0.085333333 0.103278689 0.098918919 0.097674419 0.12545 0.13364 0.12500 0.12000 0.10909 0.13500 0.10971 0.13448 0.15097 0.15000 0.140769231 0.107647059 0.125714286 0.157142857 0.138 0.114545455 0.147272727 0.132 0.14 0.106153846 Glucose 2.720769231 3.088965517 3.234 1.601818182 0.317142857 0.142857143 0.111428571 0.103902439 0.304285714 0.1 4.857272727 1.601052632 2.000571429 0.7475 1.521666667 0.175555556 0.092 0.074754098 0.257837838 0.182790698 0.54545 0.25091 0.17000 0.42783 0.23727 0.38143 0.40457 0.25241 0.12581 0.15750 0.099230769 0.700588235 0.16 0.131428571 0.609 2.350909091 0.69 1.1232 2.21 0.318461538 Glutamate 4.273846154 4.274482759 4.098 3.914545455 4.06 2.677142857 2.957142857 2.114634146 3.561428571 2.462857143 3.826363636 3.811578947 5.117142857 2.7 1.828333333 3.994444444 3.006666667 2.918360656 2.680540541 2.78372093 5.23364 3.75000 5.94000 4.88087 3.47182 3.25071 4.32171 4.42966 4.56581 3.45750 3.643846154 3.187058824 2.542857143 2.397142857 3.231 3.725454545 3.335454545 3.8688 4.215 3.717692308 Glutamine 5.817692308 6.488275862 4.92 7.2 6.985714286 4.911428571 5.218285714 5.68097561 5.089285714 3.997142857 5.836363636 4.338947368 5.934857143 4.41 2.926666667 6.871111111 4.909333333 4.401639344 4.094594595 5.448837209 5.84455 8.04000 8.38500 5.79913 4.38273 6.43929 5.56114 5.35241 4.57355 5.18250 5.875384615 5.467058824 4.857142857 6.817142857 7.044 6.54 5.686363636 6.456 5.525 3.265384615 Glutathione 0.503076923 0.457241379 0.396 0.489090909 0.34 0.334285714 0.291428571 0.361463415 0.439285714 0.277142857 0.42 0.320526316 0.423428571 0.2575 0.211666667 0.4 0.350666667 0.337377049 0.342162162 0.318139535 0.27545 0.36545 0.46000 0.38870 0.30273 0.48000 0.39771 0.50069 0.52839 0.53500 0.530769231 0.467647059 0.371428571 0.454285714 0.459 0.414545455 0.466363636 0.4944 0.44 0.320769231 Glycine 0.565384615 0.554482759 0.588 0.674545455 0.591428571 0.451428571 0.445714286 0.602926829 0.685714286 0.334285714 0.572727273 0.566842105 0.598285714 0.8175 0.638333333 0.806666667 0.522666667 0.582295082 0.531891892 0.567906977 0.58364 0.38455 0.53500 0.50609 0.48818 0.70714 0.57086 0.58552 0.62129 0.61250 0.653076923 0.621176471 0.494285714 0.808571429 0.591 0.763636364 0.684545455 0.6672 0.64 0.422307692 Histidine 0.265384615 0.231724138 0.252 0.230909091 0.242857143 0.154285714 0.169714286 0.203414634 0.177857143 0.148571429 0.212727273 0.173684211 0.207428571 0.17 0.091666667 0.288888889 0.185333333 0.155409836 0.181621622 0.133953488 0.18545 0.19364 0.17000 0.24261 0.19909 0.16714 0.14400 0.16138 0.16258 0.19000 0.133846154 0.162352941 0.091428571 0.171428571 0.165 0.196363636 0.193636364 0.144 0.175 0.184615385 IMP 0.073846154 0.107586207 0.069 0.603636364 0.422857143 0.042857143 0.044571429 0.033658537 0.047142857 0.04 0.076363636 0.178421053 0.253714286 0.3325 0.101666667 0.046666667 0.057333333 0.040327869 0.053513514 0.039069767 0.09000 0.08455 0.14000 0.08870 0.07909 0.04500 0.07543 0.05793 0.05226 0.04000 0.099230769 0.068823529 0.06 0.04 0.057 0.130909091 0.040909091 0.0408 0.04 0.06 Inosine 0.096923077 0.062068966 0.066 0.145454545 0.248571429 0.2 0.166285714 0.077560976 0.124285714 0.157142857 0.057272727 0.094736842 0.138857143 0.3675 0.431666667 0.177777778 0.349333333 0.138688525 0.204324324 0.149302326 0.08182 0.12000 0.11500 0.09652 0.05727 0.07929 0.07029 0.07241 0.03677 0.02750 0.057692308 0.061764706 0.211428571 0.174285714 0.105 0.158181818 0.068181818 0.0768 0.08 0.064615385 Isoleucine 0.066923077 0.06 0.057 0.061818182 0.082857143 0.054285714 0.056571429 0.054146341 0.111428571 0.051428571 0.073636364 0.048947368 0.065142857 0.09 0.073333333 0.074444444 0.064 0.080655738 0.071351351 0.097674419 0.03273 0.02727 0.02500 0.03391 0.02727 0.07714 0.03429 0.03931 0.06387 0.05250 0.09 0.051176471 0.085714286 0.074285714 0.09 0.070909091 0.043636364 0.0648 0.085 0.025384615 Lactate 9.152307692 7.843448276 6.495 8.86 10.43142857 10.98571429 8.88 8.32097561 9.724285714 5.611428571 8.258181818 6.655263158 11.59371429 9.6975 9.86 10.11888889 8.170666667 9.806557377 11.29621622 10.83488372 9.79636 7.03364 11.33000 8.24870 4.08273 9.49286 8.98629 8.00897 9.29419 9.21250 7.583076923 5.16 8.08 4.994285714 9.291 10.94727273 5.397272727 5.544 6.675 6.763846154 Leucine 0.103846154 0.097241379 0.114 0.114545455 0.14 0.111428571 0.121714286 0.112682927 0.203571429 0.091428571 0.12 0.101052632 0.118285714 0.1575 0.133333333 0.156666667 0.122666667 0.139672131 0.150810811 0.14372093 0.04636 0.03273 0.04500 0.04435 0.03545 0.14357 0.05829 0.07448 0.11806 0.10250 0.138461538 0.086470588 0.131428571 0.134285714 0.153 0.130909091 0.109090909 0.108 0.155 0.036923077 Lysine 0.193846154 0.293793103 0.195 0.407272727 0.4 0.225714286 0.166285714 0.18 0.282857143 0.265714286 0.201818182 0.146842105 0.305142857 0.2225 0.13 0.137777778 0.208 0.149508197 0.165405405 0.18 0.24545 0.30000 0.25000 0.26609 0.16091 0.22929 0.14400 0.20897 0.21677 0.17250 0.175384615 0.24 0.18 0.197142857 0.189 0.229090909 0.248181818 0.1392 0.465 0.279230769 Methionine 0.087692308 0.093103448 0.093 0.1 0.074285714 0.111428571 0.147428571 0.14195122 0.169285714 0.091428571 0.095454545 0.082105263 0.137142857 0.065 0.05 0.161111111 0.126666667 0.132786885 0.124864865 0.110232558 0.17727 0.12273 0.07000 0.11217 0.03000 0.24214 0.14400 0.15724 0.19161 0.25750 0.138461538 0.109411765 0.228571429 0.234285714 0.141 0.289090909 0.242727273 0.132 0.18 0.131538462 N,N-Dimethylglycine 0.034615385 0.031034483 0.033 0.030909091 0.031428571 0.025714286 0.025714286 0.020487805 0.017142857 0.02 0.03 0.025263158 0.029142857 0.02 0.011666667 0.022222222 0.024 0.020655738 0.024324324 0.020930233 0.03000 0.03000 0.03500 0.03652 0.02727 0.03214 0.02571 0.02690 0.03097 0.03250 0.025384615 0.03 0.025714286 0.022857143 0.033 0.043636364 0.038181818 0.0336 0.04 0.053076923 NAD+ 0.925384615 0.703448276 0.777 0.645454545 0.668571429 0.731428571 0.589714286 0.535609756 0.627857143 0.528571429 0.758181818 0.637894737 0.663428571 0.185 0.275 0.537777778 0.657333333 0.553770492 0.585405405 0.551162791 0.62182 0.48818 0.60500 0.59739 0.54545 0.45214 0.44400 0.47793 0.43355 0.48750 0.339230769 0.591176471 0.36 0.331428571 0.603 0.523636364 0.542727273 0.5328 0.665 0.500769231 NADP+ 0.053076923 0.064137931 0.084 0.054545455 0.042857143 0.042857143 0.049714286 0.045365854 0.062142857 0.045714286 0.070909091 0.06 0.051428571 0.04 0.031666667 0.042222222 0.041333333 0.038360656 0.055135135 0.053023256 0.03000 0.04909 0.05000 0.05217 0.04091 0.04929 0.04286 0.04345 0.06000 0.04750 0.050769231 0.054705882 0.028571429 0.04 0.063 0.038181818 0.06 0.0528 0.065 0.055384615 Niacinamide 0.33 0.293793103 0.24 0.354545455 0.291428571 0.134285714 0.140571429 0.159512195 0.162857143 0.165714286 0.220909091 0.194210526 0.298285714 0.425 0.186666667 0.156666667 0.154666667 0.146557377 0.152432432 0.131162791 0.23727 0.23455 0.26500 0.24261 0.19636 0.21429 0.20571 0.14897 0.19355 0.21750 0.214615385 0.169411765 0.257142857 0.225714286 0.231 0.267272727 0.207272727 0.18 0.29 0.182307692 O-Acetylcarnitine 0.140769231 0.126206897 0.078 0.06 0.131428571 0.145714286 0.186857143 0.13902439 0.132857143 0.128571429 0.12 0.126315789 0.216 0.1 0.1 0.186666667 0.205333333 0.160327869 0.217297297 0.173023256 0.17455 0.10364 0.16000 0.12783 0.06545 0.22500 0.12171 0.17793 0.31355 0.25250 0.117692308 0.056470588 0.148571429 0.117142857 0.084 0.190909091 0.117272727 0.1464 0.14 0.096923077 O-Phosphocholine 0.177692308 0.165517241 0.168 0.172727273 0.145714286 0.094285714 0.099428571 0.073170732 0.094285714 0.102857143 0.141818182 0.126315789 0.150857143 0.11 0.145 0.191111111 0.138666667 0.134754098 0.11027027 0.104651163 0.13909 0.15545 0.14000 0.14870 0.09818 0.13500 0.10800 0.14690 0.15484 0.14250 0.163846154 0.107647059 0.131428571 0.145714286 0.177 0.201818182 0.130909091 0.1608 0.18 0.113076923 O-Phosphoethanolamine 0.36 0.175862069 0.249 0.414545455 0.322857143 0.188571429 0.137142857 0.155121951 0.387857143 0.162857143 0.182727273 0.233684211 0.265714286 0.3175 0.2 0.173333333 0.182666667 0.207540984 0.199459459 0.283255814 0.21273 0.19636 0.25500 0.31826 0.28091 0.13500 0.21257 0.15931 0.16258 0.20250 0.33 0.197647059 0.231428571 0.248571429 0.285 0.272727273 0.261818182 0.2232 0.415 0.288461538 Pantothenate 0.066923077 0.045517241 0.045 0.074545455 0.088571429 0.057142857 0.046285714 0.055609756 0.064285714 0.062857143 0.06 0.047368421 0.048 0.06 0.045 0.041111111 0.041333333 0.033442623 0.063243243 0.027906977 0.04364 0.08727 0.12500 0.06000 0.04364 0.05143 0.04971 0.03517 0.03677 0.03500 0.071538462 0.045882353 0.042857143 0.04 0.078 0.065454545 0.06 0.0456 0.095 0.043846154 Phenylalanine 0.062307692 0.047586207 0.069 0.063636364 0.077142857 0.028571429 0.046285714 0.045365854 0.062142857 0.031428571 0.049090909 0.039473684 0.054857143 0.055 0.055 0.094444444 0.054666667 0.042295082 0.06 0.044651163 0.04636 0.05455 0.06000 0.04696 0.03818 0.06429 0.05657 0.05379 0.07548 0.05500 0.057692308 0.037058824 0.04 0.054285714 0.084 0.038181818 0.051818182 0.0336 0.065 0.057692308 Pyruvate 0.191538462 0.148965517 0.177 0.152727273 0.134285714 0.122857143 0.114857143 0.093658537 0.137142857 0.108571429 0.15 0.080526316 0.092571429 0.105 0.075 0.101111111 0.113333333 0.087540984 0.089189189 0.10744186 0.08455 0.09545 0.06000 0.07826 0.06273 0.11357 0.04286 0.08483 0.08710 0.09250 0.124615385 0.118235294 0.117142857 0.1 0.189 0.201818182 0.139090909 0.1536 0.205 0.071538462 Serine 0.470769231 0.488275862 0.378 0.598181818 0.622857143 0.431428571 0.627428571 0.725853659 1.167857143 0.48 0.466363636 0.374210526 0.536571429 0.4625 0.461666667 1.122222222 0.586666667 0.610819672 0.713513514 0.602790698 0.37364 0.31636 0.32500 0.19826 0.33545 0.51429 0.44229 0.62276 0.59613 0.44500 0.590769231 0.351176471 0.5 0.742857143 0.561 0.616363636 0.654545455 0.5328 0.665 0.364615385 Succinate 0.729230769 0.533793103 0.405 0.878181818 1.102857143 1.017142857 0.973714286 0.762439024 0.668571429 0.705714286 0.553636364 0.336315789 0.637714286 0.645 0.708333333 0.754444444 0.984 0.780983607 0.940540541 0.985116279 0.45545 0.39273 0.44500 0.42522 0.28364 0.38786 0.21943 0.44483 0.67742 0.66000 0.302307692 0.333529412 0.531428571 0.297142857 0.504 0.621818182 0.27 0.3096 0.445 0.383076923 Taurine 40.43076923 40.04896552 38.601 37.87818182 38.68285714 31.88857143 30.02228571 29.85365854 31.01142857 25.30285714 36.28363636 30.6 35.94514286 24.73 20.04166667 26.12444444 29.22 28.12819672 28.34108108 29.38465116 37.26000 36.87000 35.61000 41.99217 33.24545 41.64214 34.45714 36.56276 39.84774 39.40750 31.53923077 32.57294118 25.95428571 31.17714286 37.08 43.16727273 39.38181818 37.584 38.655 32.39538462 Threonine 0.318461538 0.190344828 0.168 0.263636364 0.38 0.291428571 0.324 0.237073171 0.432857143 0.228571429 0.267272727 0.228947368 0.197142857 0.1825 0.116666667 0.303333333 0.305333333 0.298032787 0.257837838 0.274883721 0.23455 0.19909 0.23000 0.24000 0.21545 0.27214 0.21943 0.25655 0.28839 0.28750 0.401538462 0.245294118 0.222857143 0.265714286 0.408 0.294545455 0.182727273 0.1344 0.235 0.177692308 Tyrosine 0.080769231 0.072413793 0.069 0.109090909 0.071428571 0.091428571 0.084 0.071707317 0.096428571 0.048571429 0.081818182 0.053684211 0.089142857 0.065 0.08 0.107777778 0.073333333 0.08557377 0.092432432 0.080930233 0.05727 0.05182 0.05500 0.06261 0.05182 0.08357 0.05314 0.05793 0.09290 0.07750 0.06 0.040588235 0.068571429 0.06 0.075 0.076363636 0.076363636 0.0576 0.1 0.06 UDP-N-Acetylglucosamine 0.046153846 0.037241379 0.057 0.021818182 0.031428571 0.037142857 0.032571429 0.04097561 0.017142857 0.022857143 0.040909091 0.025263158 0.029142857 0.0225 0.025 0.033333333 0.021333333 0.02557377 0.038918919 0.03627907 0.04364 0.04091 0.09000 0.02870 0.04636 0.05143 0.02057 0.03931 0.02516 0.04250 0.043846154 0.031764706 0.025714286 0.065714286 0.036 0.043636364 0.049090909 0.0408 0.06 0.032307692 UDP-glucose 0.069230769 0.033103448 0.081 0.065454545 0.037142857 0.074285714 0.073714286 0.090731707 0.145714286 0.065714286 0.068181818 0.061578947 0.068571429 0.1 0.085 0.1 0.064 0.066885246 0.066486486 0.076744186 0.08182 0.08182 0.04500 0.09913 0.05727 0.09857 0.06514 0.05586 0.11226 0.06750 0.046153846 0.065294118 0.082857143 0.034285714 0.048 0.076363636 0.081818182 0.0432 0.075 0.046153846 Valine 0.138461538 0.134482759 0.123 0.116363636 0.154285714 0.128571429 0.135428571 0.124390244 0.182142857 0.094285714 0.144545455 0.107368421 0.138857143 0.145 0.135 0.167777778 0.137333333 0.152459016 0.12972973 0.178604651 0.06818 0.03818 0.03500 0.06261 0.05182 0.13286 0.07543 0.08897 0.13548 0.12500 0.145384615 0.098823529 0.125714286 0.134285714 0.156 0.147272727 0.092727273 0.1128 0.15 0.046153846 myo-Inositol 0.422307692 0.372413793 0.387 0.554545455 0.511428571 0.214285714 0.245142857 0.207804878 0.276428571 0.242857143 0.379090909 0.423157895 0.462857143 0.385 0.683333333 0.276666667 0.317333333 0.345245902 0.384324324 0.279069767 0.45818 0.37364 0.40500 0.30783 0.33273 0.34500 0.33086 0.27103 0.34258 0.37000 0.304615385 0.229411765 0.302857143 0.331428571 0.414 0.370909091 0.319090909 0.288 0.415 0.253846154 sn-Glycero-3-phosphocholine 0.985384615 1.069655172 0.975 0.8 0.768571429 0.697142857 0.620571429 0.613170732 0.48 0.442857143 0.818181818 0.672631579 0.586285714 0.495 0.34 0.574444444 0.498666667 0.481967213 0.587027027 0.514883721 0.57818 0.51818 0.70500 0.72783 0.37909 0.62357 0.48686 0.50897 0.48387 0.55500 0.447692308 0.381176471 0.368571429 0.4 0.471 0.649090909 0.463636364 0.5112 0.46 0.468461538 NMR_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name HMDB ID 3-Hydroxybutyrate HMDB0000011 ADP HMDB0001341 AMP HMDB0000045 ATP HMDB0000538 Acetate HMDB0000042 Alanine HMDB0000161 Asparagine HMDB0000168 Aspartate HMDB0000191 Choline HMDB0000097 Citrate HMDB0000094 Creatine HMDB0000064 Creatine phosphate HMDB0001511 Creatinine HMDB0000562 Formate HMDB0000142 Fumarate HMDB0000134 GTP HMDB0001273 Glucose HMDB0000122 Glutamate HMDB0000148 Glutamine HMDB0000641 Glutathione HMDB0000125 Glycine HMDB0000123 Histidine HMDB0000177 IMP HMDB0000189 Inosine HMDB0000195 Isoleucine HMDB0000172 Lactate HMDB0000190 Leucine HMDB0000687 Lysine HMDB0000182 Methionine HMDB0000696 N,N-Dimethylglycine HMDB0000092 NAD+ HMDB0000902 NADP+ HMDB0304435 Niacinamide HMDB0001406 O-Acetylcarnitine HMDB0000201 O-Phosphocholine HMDB0062577 O-Phosphoethanolamine HMDB0000224 Pantothenate HMDB0000210 Phenylalanine HMDB0000159 Pyruvate HMDB0000243 Serine HMDB0000187 Succinate HMDB0000254 Taurine HMDB0000251 Threonine HMDB0000167 Tyrosine HMDB0000158 UDP-N-Acetylglucosamine HMDB0000934 UDP-glucose HMDB0000286 Valine HMDB0000883 myo-Inositol HMDB0000211 sn-Glycero-3-phosphocholine HMDB0059660 METABOLITES_END #END