#METABOLOMICS WORKBENCH shancock_20250218_223155 DATATRACK_ID:5646 STUDY_ID:ST003757 ANALYSIS_ID:AN006168 PROJECT_ID:PR002341 VERSION 1 CREATED_ON February 20, 2025, 2:01 pm #PROJECT PR:PROJECT_TITLE Untargeted lipidomics of gemcitabine-resistant PDAC cells PR:PROJECT_SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with few PR:PROJECT_SUMMARY treatment options and poor survivability. In this work we sought to characterise PR:PROJECT_SUMMARY metabolic adaptations to gemcitabine (GEMC)-based chemotherapy exposure to PR:PROJECT_SUMMARY discover new therapeutic targets for improving treatment efficacy. We show that PR:PROJECT_SUMMARY GEMC resistance (GEMR) upregulates de novo lipogenesis in Panc1 and MiaPaCa2 PR:PROJECT_SUMMARY cells. PR:INSTITUTE Victor Chang Cardiac Research Institute PR:LAST_NAME Hancock PR:FIRST_NAME Sarah PR:ADDRESS Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW, 2010, Australia PR:EMAIL s.hancock@victorchang.edu.au PR:PHONE +61414537526 #STUDY ST:STUDY_TITLE Untargeted lipidomics of gemcitabine-resistant PDAC cells ST:STUDY_SUMMARY In this work we developed gemcitabine (GEMC) resistant (GEMR) PDAC cell lines ST:STUDY_SUMMARY from Panc1 and MiaPaCa2 cells. This dataset contains results and raw data for ST:STUDY_SUMMARY untargeted lipidomics of Panc1 cells, including control (CON), and GEMR cells ST:STUDY_SUMMARY alongside internal quality controls (iQC) and blank samples for background ST:STUDY_SUMMARY subtraction (as described under sample prep). Untargeted lipidomics enabled the ST:STUDY_SUMMARY quantification of more than 400 distinct molecular lipid species within Panc1 & ST:STUDY_SUMMARY MiaPaCa2 control (CON) & GEMR cells from 12 different classes of lipid, with 77 ST:STUDY_SUMMARY molecular species being differentially abundant between Panc1 control and GEMR ST:STUDY_SUMMARY cells following unpaired t test. Data were analysed using MS-DIAL 4.9. ST:INSTITUTE Victor Chang Cardiac Research Institute ST:LAST_NAME Hancock ST:FIRST_NAME Sarah ST:ADDRESS Level 7 Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW 2010 ST:ADDRESS Australia ST:EMAIL s.hancock@victorchang.edu.au ST:PHONE +61414537526 #SUBJECT SU:SUBJECT_TYPE Cultured cells SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:CELL_STRAIN_DETAILS Panc1 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - Blank_cells_neg Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_neg.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Blank_cells_neg_20210814030609 Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_neg_20210814030609.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Blank_cells_pos Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_pos.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Blank_cells_pos_20210813215440 Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_pos_20210813215440.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_neg Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_neg.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_neg_20210814033722 Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_neg_20210814033722.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_pos Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_pos.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_pos_20210813222552 Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_pos_20210813222552.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Panc1_CON_p1_neg Sample source:Panc1 cells | group:CON RAW_FILE_NAME(Raw file name)=Panc1_CON_p1_neg.mzML; protein amount=149.2651285 SUBJECT_SAMPLE_FACTORS - Panc1_CON_p1_pos Sample source:Panc1 cells | group:CON RAW_FILE_NAME(Raw file name)=Panc1_CON_p1_pos.mzML; protein amount=149.2651285 SUBJECT_SAMPLE_FACTORS - Panc1_CON_p2_neg Sample source:Panc1 cells | group:CON RAW_FILE_NAME(Raw file name)=Panc1_CON_p2_neg.mzML; protein amount=100.2281304 SUBJECT_SAMPLE_FACTORS - Panc1_CON_p2_pos Sample source:Panc1 cells | group:CON RAW_FILE_NAME(Raw file name)=Panc1_CON_p2_pos.mzML; protein amount=100.2281304 SUBJECT_SAMPLE_FACTORS - Panc1_CON_p3_neg Sample source:Panc1 cells | group:CON RAW_FILE_NAME(Raw file name)=Panc1_CON_p3_neg.mzML; protein amount=79.09305324 SUBJECT_SAMPLE_FACTORS - Panc1_CON_p3_pos Sample source:Panc1 cells | group:CON RAW_FILE_NAME(Raw file name)=Panc1_CON_p3_pos.mzML; protein amount=79.09305324 SUBJECT_SAMPLE_FACTORS - Panc1_GEMR_p1_neg Sample source:Panc1 cells | group:GEMR RAW_FILE_NAME(Raw file name)=Panc1_GEMR_p1_neg.mzML; protein amount=184.7074903 SUBJECT_SAMPLE_FACTORS - Panc1_GEMR_p1_pos Sample source:Panc1 cells | group:GEMR RAW_FILE_NAME(Raw file name)=Panc1_GEMR_p1_pos.mzML; protein amount=184.7074903 SUBJECT_SAMPLE_FACTORS - Panc1_GEMR_p2_neg Sample source:Panc1 cells | group:GEMR RAW_FILE_NAME(Raw file name)=Panc1_GEMR_p2_neg.mzML; protein amount=167.9988515 SUBJECT_SAMPLE_FACTORS - Panc1_GEMR_p2_pos Sample source:Panc1 cells | group:GEMR RAW_FILE_NAME(Raw file name)=Panc1_GEMR_p2_pos.mzML; protein amount=167.9988515 SUBJECT_SAMPLE_FACTORS - Panc1_GEMR_p3_neg Sample source:Panc1 cells | group:GEMR RAW_FILE_NAME(Raw file name)=Panc1_GEMR_p3_neg.mzML; protein amount=129.6441352 SUBJECT_SAMPLE_FACTORS - Panc1_GEMR_p3_pos Sample source:Panc1 cells | group:GEMR RAW_FILE_NAME(Raw file name)=Panc1_GEMR_p3_pos.mzML; protein amount=129.6441352 #COLLECTION CO:COLLECTION_SUMMARY Samples were obtained from established immortalised adherent human pancreatic CO:COLLECTION_SUMMARY ductal adenocarcinoma cells (Panc1). Cells were cultured in high glucose DMEM CO:COLLECTION_SUMMARY containing 4.5 g/L glucose and 4 mM glutamine and were supplemented with 10% CO:COLLECTION_SUMMARY FCS. Cells were cultured under 5% CO2 at 37ºC and routinely passaged every 2-3 CO:COLLECTION_SUMMARY days (when ~80-90% confluent). Cell lines were regularly screened for mycoplasma CO:COLLECTION_SUMMARY infection. CO:SAMPLE_TYPE Pancreas #TREATMENT TR:TREATMENT_SUMMARY Panc1 GEMR cells were produced by serial treatment with escalating doses of TR:TREATMENT_SUMMARY gemcitabine for approximately 12 weeks. The final concentration of GEMC for TR:TREATMENT_SUMMARY Panc1 cells was 150 nM, resulting in a half-maximal inhibitory concentration of TR:TREATMENT_SUMMARY 720.5 nM (approximately 2.5 times increase over control (CON) cells, 273.3 nM) #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Lipids were extracted from cells grown to 80-90% confluency in 6 well plates SP:SAMPLEPREP_SUMMARY using a modified methyl tert-butyl ether (MTBE) method. Adherent cells were SP:SAMPLEPREP_SUMMARY washed with ice-cold PBS and scraped into methanol containing 0.01% butylated SP:SAMPLEPREP_SUMMARY hydroxytoluene and 100 pmol each of internal standards (phosphatidylcholine SP:SAMPLEPREP_SUMMARY 19:0/19:0, phosphatidylethanolamine 17:0/17:0, phosphatidylserine 17:0/17:0, SP:SAMPLEPREP_SUMMARY lysophosphatidylcholine 17:0, lysophosphatidylethanolamine 14:0, SP:SAMPLEPREP_SUMMARY phosphatidylglycerol 17:0/17:0, phosphatidic acid 17:0/17:0, ceramide SP:SAMPLEPREP_SUMMARY d18:1/17:0, dihydrosphingomyelin 12:0, cholesteryl ester 22:1, diacylglycerol SP:SAMPLEPREP_SUMMARY 17:0/17:0, D5-triacylglycerol 16:0/16:0/16:0 and cardiolipin SP:SAMPLEPREP_SUMMARY 14:0/14:0/14:0/14:0). An empty well was also scraped for use in background SP:SAMPLEPREP_SUMMARY subtraction. To this, MTBE was added at a ratio of 3:1 v/v, and extracts were SP:SAMPLEPREP_SUMMARY rotated overnight at 4ºC. Following overnight rotation, 1 part of ice-cold 150 SP:SAMPLEPREP_SUMMARY mM ammonium acetate was added, samples were vortexed vigorously and centrifuged SP:SAMPLEPREP_SUMMARY at 2000 x g for 5 min. The upper organic phase containing lipids was transferred SP:SAMPLEPREP_SUMMARY into a 1.5 mL autosampler vial and dried under N2 at 37ºC Dried lipids were SP:SAMPLEPREP_SUMMARY reconstituted in chloroform:methanol:water (60:30:4.5 v/v/v), transferred to a SP:SAMPLEPREP_SUMMARY sleeved vial, and stored at -20ºC until analysis. The aqueous phase containing SP:SAMPLEPREP_SUMMARY the protein pellet was dried under N2 and digested with 1M NaOH overnight at SP:SAMPLEPREP_SUMMARY 4ºC. Digested protein was diluted 1:2 v/v with water and protein concentration SP:SAMPLEPREP_SUMMARY was determined using a Pierce BCA assay kit (ThermoFisher Scientific) #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Waters ACQUITY UPLC CSH C18 (100 x 2.1mm,1.7um) CH:SOLVENT_A Acetonitrile:water (3:2 v/v), 10 mM Ammonium Formate, 0.1% Formic acid CH:SOLVENT_B Acetonitrile:isopropanol (1:9 v/v), 10 mM Ammonium Formate, 0.1% Formic acid CH:FLOW_GRADIENT As described by Hu et al. 2008 J Proteome Research CH:FLOW_RATE 0.26 ml/min CH:COLUMN_TEMPERATURE 60 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive HF hybrid Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Source conditions were as follows: a spray voltage 4.0 kV in positive ion mode MS:MS_COMMENTS and 3.5 kV in negative ion mode, capillary temperature 290°C, S lens RF 50, and MS:MS_COMMENTS auxiliary gas heater temperature of 250°C. Nitrogen was used as both source and MS:MS_COMMENTS collision gas, with the sheath gas flow rate set at 20 and the auxiliary gas MS:MS_COMMENTS flow rate at 5 (arbitrary units). Data were acquired in full scan/data-dependent MS:MS_COMMENTS MS2 mode (full-scan resolution 70,000 FWHM, max ion injection time 50 ms, scan MS:MS_COMMENTS range m/z 200–1,500), with the 10 most abundant ions being subjected to MS:MS_COMMENTS collision-induced dissociation using an isolation window of 1.5 Da and a MS:MS_COMMENTS normalized stepped collision energy of 15/27 eV. Product ions were detected at a MS:MS_COMMENTS resolution of 17,500. An exclusion list for background ions was developed using MS:MS_COMMENTS extraction blanks, and mass calibration was performed in both positive and MS:MS_COMMENTS negative ionization modes before analysis to ensure mass accuracy of 5 ppm in MS:MS_COMMENTS full-scan mode. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS nmol/mg protein MS_METABOLITE_DATA_START Samples Panc1_CON_p1_pos Panc1_CON_p2_pos Panc1_CON_p3_pos Panc1_GEMR_p1_pos Panc1_GEMR_p2_pos Panc1_GEMR_p3_pos Factors Sample source:Panc1 cells | group:CON Sample source:Panc1 cells | group:CON Sample source:Panc1 cells | group:CON Sample source:Panc1 cells | group:GEMR Sample source:Panc1 cells | group:GEMR Sample source:Panc1 cells | group:GEMR CE 16:0 0.031488941 0.043065863 0.060986672942571714 0.023896308932954132 0.022444761 0.028920842 CE 16:1 0.049880762 0.042743035 0.060935864 0.051087616 0.04626502 0.044245989 CE 17:1 0.014543325 0 0.021544681656107584 0.013107375946356104 0.014300103680164626 0.014192795142397113 CE 18:1 0.2246224164150446 0.29273257620243076 0.3505530881026436 0.2189194774925636 0.19607585097519908 0.2068343811608906 CE 18:2 0.15839121339812381 0.15865057558989526 0.23507289700890815 0.1584479380721985 0.14281347307540082 0.15649316399635874 CE 18:3 0.023171223 0.008785389 0.016866781352621353 0.038953403172973064 0.032316448347183134 0.026082886 CE 20:1 0.044542602687480976 0.038427005 0.041645470167491434 0.042293182 0.030297712221163717 0.034026701 CE 20:3 0.12508124624382436 0.081475805 0.15364906614103388 0.12637821225295207 0.11091263312178035 0.092512924 CE 20:4 0.291802333 0.161319864 0.28503043085035684 0.36037233166748633 0.3125034337492136 0.28558396495271443 CE 20:5 0.040243366 0.011443543454388768 0.020318995496609947 0.078528853 0.065564583 0.048370041833747324 CE 22:2 0.017142411996008432 0 0 0.019243527783476027 0.014742201377574007 0.012794305502060396 CE 22:3 0.030045029207121432 0.027871869 0.037920849522777696 0.031010768184299663 0.022033241067365615 0.020588315386963707 CE 22:4 0.038532366 0.037200763 0.053717477 0.048615493684160245 0.038360321667664975 0.028080968818962056 CE 22:5 0.029241407119697832 0.026702597 0.040852169338585584 0 0 0 CE 22:6 0.24090082803311355 0.095050383 0.16012201168986345 0.2719487956957715 0.21100765304768374 0.20394746359586108 CE 24:1 0.025550155787894258 0.017755426304274163 0.026826311067199408 0.022637854315639652 0.016272062 0.016065658652270734 CE 24:2 0.016062936 0.013874850459632819 0.014987652009207911 0.015586778293538545 0.009446418 0.007663541 CE 24:3 0.034767287 0.026815791 0.031657030008669214 0.025181032255096058 0.016435053 0.014282697 CE 24:4 0.043086022 0.040758700389176984 0.059977762830644835 0.029526600697890166 0.019636012062364906 0.016419485 CE 24:5 0.081182619 0.075684842 0.1310586772608318 0.023372416761385906 0.022309182809711753 0.029981388 CE 24:6 0.1199319586870774 0.088577442 0.15031736996926284 0.038940042 0.034625790066951906 0.04703087 CE 26:1 0.011805173 0.008905902 0.012866628158766187 0.012455947681125703 0.006868043 0.005243922 CE 26:3 0.028087826 0.021685859851255183 0.034532642 0.015494639381494837 0.008604475 0.007770246 CE 26:4 0.054918538 0.040161683 0.049777081595898005 0.028086181689273966 0.014669229116645565 0.013720420260366666 CE 26:5 0.098541778 0.082428628 0.13287644139325677 0 0 0 CE 26:6 0.15507716464536955 0.17380087087598614 0.2521324917069797 0 0 0 CE 28:6 0.094446291 0.075877448 0.10548787639603105 0 0 0 CE 30:5 0.008566852 0.005967975 0.007909035 0 0 0 CE 30:6 0.024857618734476682 0.015775142484876093 0.021844001 0 9.77167116448123e-4 0 Cer 17:1;2O/24:1 0.003941595 0.002856497 0.004611393 0.007023789 0.006679573 0.005419614 Cer 18:0;2O/16:0 0.001565955 0.00177747 0.002024711 0.002308908 0.001758085 0.001991813 Cer 18:0;2O/17:0 0.002376303 0 0.002171432 0.002335054 0.002012828 0.003009051 Cer 18:1;2O/14:0 0.002918575 0.002999422 0.003690258 0.006173375 0.005287066 0.005846162 Cer 18:1;2O/16:0 0.046577293 0.051284868 0.063357732 0.076822645 0.067420133 0.082559282 Cer 18:1;2O/18:0 0.002418113 0.003238462 0.003694069 0.003419029 0.003296192 0.004366117 Cer 18:1;2O/19:0 6.698293723516357e-4 0 2.682574366651295e-4 4.207506945846408e-4 4.7529917314546947e-4 5.006406372985632e-4 Cer 18:1;2O/22:0 0.008092382 0.008969489 0.012421021575973282 0.012134788727796785 0.01141812 0.012078581679691502 Cer 18:1;2O/22:1 0.004524772 0.003043529 0.005467516 0.011760446868653643 0.009468807 0.008578544 Cer 18:1;2O/23:0 0.003403775 0.003183765 0.004575603 0.004386737 0.003935668 0.003912895 Cer 18:1;2O/24:0 0.03327395 0.028461232 0.037846216 0.036831411076509335 0.031836703 0.034834538 Cer 18:1;2O/24:1 0.086214749 0.067308857 0.10506708224595376 0.1348765127068965 0.11285469915492728 0.12670815658714119 Cer 18:1;2O/26:1 0.003092947 0.002296113 0.003124136 0.005084568 0.003352453 0.003429503 Cer 18:1;2O/26:2 0.001470005 0.001179534 0.001651359 0.003773911 0.002331099 0.001841185 Cer 18:2;2O/16:0 0.00441134 0.003607144 0.006013067 0.009449834 0.008226666 0.008927295 Cer 18:2;2O/24:0 0.007665322 0.00679374 0.006648214 0.009176587 0.007417397 0.007827227 Cer 18:2;2O/24:1 0.019129292939469928 0.013158721017216867 0.020698764341308802 0.033238685 0.028081629 0.027354929707639673 DG 14:0_18:1 0.062775518 0.040580883 0.051148436 0.3234694151844377 0.23113275609831274 0.18884477005776062 DG 16:0_16:0 0.029990790221431547 0.027915947088628257 0.032047411594604315 0.089418057 0.063796869 0.10463634131686998 DG 16:0_17:1 0.005163262 0 0.004632842 0.006599127 0.004913564 0.00512213 DG 16:0_18:0 0.004524844 0 0 0 0.009875752 0.010123401857161818 DG 16:0_18:1 0.184546878 0.12480671891741793 0.14021776776771244 0.6094374872656045 0.44302567693705325 0.4671571450305532 DG 16:0_20:1 0.050659359 0.034248664678344455 0.041307960604325025 0.083305903 0.077104167 0.1035794049445154 DG 16:0_22:3 0.003522839 0.004375863 0 0.005588026 0.005270359 0.002658581 DG 16:0_22:5 0.008978583 0.006675067 0.007654929 0.012115432431736198 0.009673536 0.014273933286236292 DG 16:0_36:4 0.031540562490706456 0 0 0.13767607243318303 0.13364159104519108 0.10515943991102795 DG 16:1_16:1 0.003940878 0.003650518 0.004034051 0.040024916307752664 0.028014199322467886 0.011928597129293617 DG 16:1_18:1 0.066082004 0.043562713696455035 0.047939387 0.3066833734552324 0.18926103411170558 0.14767975523048824 DG 16:1_18:2 4.6125550668720753e-4 6.724482018256784e-4 4.2040074048874907e-4 0.021933240582104163 0.009297139 0.004232169 DG 17:1_18:1 0.00475641 0.003586944 0.004112267 0.013447025001854601 0.010621046634774338 0.011438743505681448 DG 18:1_18:1 0.11228596684041589 0.084054641 0.089854536 0.35796829087571497 0.2831378038618908 0.3111290877891581 DG 18:1_18:2 0.020266910673115115 0.011274798222130766 0.015507581457953628 0.10154136024757054 0.070472155 0.054330063336179096 DG 18:1_20:1 0 0.017602882796473845 0 0.052069743 0 0.060340447 DG 18:1_20:2 0.010653784362636766 0.007208004 0.007414754 0.041541595 0.028716636 0.0294491 DG 18:1_20:3 0.00652233 0 0.003999663 0.022140385765581118 0.014412895563898694 0.013193416505947278 DG 18:1_22:3 0.003315122 0.002062465 0.002649311 0.010560646108417704 0.005356202 0.003729977 LPC 16:0/0:0 0.015317425551384932 0.014484284907924846 0.019908295437471128 0.024622969783763042 0.015529813575639494 0.017572378499112327 LPC 18:0/0:0 0.009781742 0.013214032888270721 0.019057475833133587 0.008648658 0.00879012 0.010591625404446454 LPC 18:1/0:0 0.010493683 0.009427265 0.013399995965937444 0.012512371230915306 0.008227028 0.010429142410633174 LPC 28:0 0.1849492188831513 0.058899181 0.15363945095074746 0.084348646 0.093659288 0.13786790409342495 LPE 22:6 0.012812114549443657 0.012709772 0 0.014210762 0 0.028594587865193373 SM 32:0;2O 0.006858805 0 0 0.010080584795483512 0.005251826 0.004879149 SM 32:1;2O 0.11245322414393202 0.083874174 0.11965004086801904 0.1372731616870652 0.1046062952326397 0.1180541005264837 SM 32:2;2O 0.002454948 0.003565104 0.004001282 0.00369688 0.003096598 0.002560761 SM 33:1;2O 0.1081970636143709 0.041587184 0.057412243 0.057776616 0.052839575656519706 0.071229408 SM 34:0;2O 0.068145899 0.068916975 0.098065472 0.077224179 0.040880664 0.044677666 SM 34:1;2O 1.8474390065317348 5.860554735419771 5.986067727280735 1.1112361464173035 1.3182835187116724 1.2345025648438508 SM 34:2;2O 0.13124259546865535 0.093324268 0.12457051801107931 0.13923215242534834 0.11691857796382232 0.14274368370653231 SM 36:1;2O 0.048844270187895694 0.052496864 0.09465111 0.020555057 0.019390528138351147 0.030355206151622807 SM 36:2;2O 0.020117413726000153 0.031831993 0.036368850543117455 0.010705272031951572 0.00925255 0.012954515583885225 SM 38:1;2O 0.017065426 0.015415726342245856 0.023344725064757245 0.009165915 0.006706733 0.009968449 SM 39:1;2O 0 0.003223686 0.003086483 0.001797236 0 0.001034794 SM 40:1;2O 0.10416993036099512 0.091935447 0.12446801521579975 0.053088852 0.039994098 0.055391146 SM 40:2;2O 0.11081280970544409 0.098425067683044265 0.21967842751453098 0.11531531105471217 0.081677942 0.095906307 SM 41:1;2O 0.019414826179776058 0.019574773093798015 0.029765565776576262 0.00990479 0.007463265 0.008652496 SM 41:4;2O 0.019547838 0.018490174213791025 0.024223431337789456 0.011719846646222465 0.011810699124594428 0.036395030609496296 SM 42:1;2O 0.22459265621795244 0.14925292376015536 0.24676078609403473 0.1187484795982617 0.082582691 0.097449616 SM 42:2;2O 0.8982530693983307 0.7892380628767152 1.1103643864418618 0.5049120615065517 0.43342486509344674 0.5661962682037318 SM 42:3;2O 0.044185609 0 0.078549209 0.03059609 0.013754956034379597 0.031529645 SM 42:4;2O 0.011860939301239814 0.013047798 0.017418936 0.010121753762619087 0.006397724 0.006304154 SM 43:2;2O 0.007188502 0.007301709 0.011922284 0.003571552 0.002515277 0.003041453 SM 43:5;2O 0.003884921 0.00354632 0.006223078 0.002357397 0.001785859 0.002212286 SM 44:3;2O 0.008525965 0.007332584 0.010367918115053536 0.010662927371879643 0.006366638 0.006294888 TG 10:0_12:0_14:0 1.5877365901499784e-4 1.5393917455717957e-4 3.518496560718647e-5 2.2102090532619697e-5 8.573185559261757e-5 5.906008399953565e-6 TG 12:0_12:0_14:0 1.624147252564567e-4 1.0939847165990709e-4 3.373361868300681e-5 3.1330708068374055e-5 9.370677752280607e-5 1.2870179930738837e-5 TG 12:0_12:0_16:0 1.4641763171584568e-4 7.661154237799175e-5 2.067243285250749e-5 8.541575351399856e-5 1.3169054651745288e-4 3.451625572922364e-5 TG 12:0_14:0_16:0 2.967016330308386e-4 1.1593539386782157e-4 7.856710700968595e-5 0.001579219 9.1099267496201e-4 4.944514374761127e-4 TG 12:0_14:0_16:1 1.3088656083301572e-4 7.336135238873865e-5 0 4.3674119260099894e-4 3.0334286921963606e-4 1.5904803638802607e-4 TG 14:0_14:0_16:0 0.001655308 0 7.017555811038902e-4 0.009055459 0.005431572 0.003348165 TG 14:0_14:0_16:1 5.688390507780651e-4 1.3552782042925817e-4 2.411071408888931e-4 0.008295109 0.003454184 0.001513544 TG 14:0_14:1_18:2 1.25525058337852e-5 0 0 3.944246150907224e-4 1.1508872146168513e-4 3.6888191415958465e-5 TG 14:0_15:0_16:0 5.315601419896104e-4 0 2.5878073388229116e-4 0.001595818 9.663997897959586e-4 7.385885492594825e-4 TG 14:0_15:0_16:1 1.8702104613345008e-4 0 0 9.385106871408765e-4 4.780854223253974e-4 2.6250892483909176e-4 TG 14:0_16:0_16:0 0.010643965104930953 0.003796101 0.006746622 0.03792389 0.029202251272082678 0.020641466460497124 TG 14:0_16:0_16:1 0.0056922 0.001570999 0.001714953 0.042796474 0.022973905203225214 0.012586803445042346 TG 14:0_16:0_18:0 0.015706297024886424 0.012055948067198875 0.014763988078218404 0.034236540318386945 0.025008779615576182 0.021993049 TG 14:0_16:0_18:1 0.049043011470912834 0.025779961205533056 0.029262863520989408 0.17669787768947762 0.13283778218862424 0.092711727 TG 14:0_16:0_22:5 6.587653245323314e-4 2.1397916063655052e-4 3.192594881595641e-4 0.002786596 0.0016265 8.464110594540421e-4 TG 14:0_16:0_22:6 1.9345350823958148e-4 1.1102053296001674e-4 1.1959106979570394e-4 4.482544365449731e-4 4.3600999368154574e-4 3.5617089746831017e-4 TG 14:0_16:1_16:1 3.010742519297194e-4 0 0 0.018127327682173403 0.006347554 0.00242906 TG 14:0_16:1_17:1 2.3362198810486298e-4 0 0 0.001811499 8.738103689291598e-4 4.073753793452968e-4 TG 14:0_16:1_18:1 0.009560847 4.4819196053924815e-4 8.534473482117125e-4 0.096439917 0.046603387527326706 0.021902373 TG 14:0_16:1_18:2 4.2101912344816165e-4 7.67764650435474e-5 8.868200031379097e-5 0.00933837 0.003254033 0.001155437 TG 14:0_16:1_20:4 0 1.2200967766190724e-5 0 0.001028092 2.7552199054365164e-4 9.361859471995235e-5 TG 14:0_17:1_18:1 0.002234801 0 8.624144204718955e-4 0.009295538 0.0054308 0.003300262 TG 14:0_18:1_22:6 5.27304744037821e-4 3.5407324289457945e-4 4.0242037664391914e-4 0.001748112 0.001269963 9.221438982856677e-4 TG 14:1_16:1_18:1 0 0 0 0.007559445 0.001828415 5.389850373871697e-4 TG 14:1_16:1_18:2 1.0864652305993154e-5 0 1.1992549975084542e-5 5.166361437122314e-4 1.5930693740063943e-4 4.994610661268694e-5 TG 15:0_16:0_16:0 0.001067531 0 2.3416444161479533e-4 0.003055923 0.002323294 0.001668191 TG 15:0_16:0_16:1 0.001459612 0 7.497182891072869e-4 0.0053037 0.00323333 0.002049477 TG 15:0_16:0_18:1 0.00493537 3.1488480449636815e-4 0.002386725 0.012386446849657052 0.009709593 0.0070496 TG 15:0_16:0_25:0 0 0 0 0 0 1.368131772132419e-4 TG 15:0_24:0_16:1 4.759248172176101e-4 3.5504705883450756e-5 3.2375816416472494e-4 2.880460828447874e-4 2.1829614122273794e-4 2.95240281496433e-4 TG 16:0_16:0_17:0 0.001426985 2.695860916554841e-4 0.00179347 0.001650409 0.00140303 0.001636965 TG 16:0_16:0_18:0 0.015112080002042314 0.00952715 0.012336044917417074 0.013181378947382938 0.011463719541703365 0.013239501779245707 TG 16:0_16:0_18:1 0.082118495 0.074998455 0.077094511 0.16270842440616512 0.12370489365263485 0.11558698119386823 TG 16:0_16:0_22:6 9.286177665283853e-4 6.737659016194286e-4 8.507202977249832e-4 0.001348899 0.001347223 0.001104533 TG 16:0_16:1_18:1 0.082583248 0.050204118 0.054077454334304186 0.32754500309061524 0.2328525661332405 0.15454797094868739 TG 16:0_17:0_18:0 0 0 0 2.0207911810150438e-4 0 3.00646424995649e-4 TG 16:0_17:0_18:1 0.00786881 0.005473392 0.007023667 0.008726938 0.007649576 0.008028242 TG 16:0_17:1_18:1 0.010044841670168421 0.007622334 0.008142102 0.022333872411531046 0.017890191 0.013450982894651303 TG 16:0_18:0_18:0 0.00420503 0.001340862 0.002922977 0 0 0.002801971 TG 16:0_18:0_18:1 0.05566574 0.042774638 0.049379685 0.054464369 0.047461517 0.057157243 TG 16:0_18:0_20:0 3.4671633082426854e-4 0 0 0 0 0 TG 16:0_18:0_20:1 0.010805431215936521 0.007523283 0.009012089 0 0 0 TG 16:0_18:0_22:1 0.0022225 0.001316974 0.001884353 0.00291877 0 0 TG 16:0_18:0_24:0 0 0 5.790674443558431e-5 0 0 5.406584348533547e-5 TG 16:0_18:1_18:1 0.16377468373907286 0.1675036834841557 0.16342210589265835 0.28980289703463596 0.23654912432813083 0.21517474138515794 TG 16:0_18:1_18:2 0.066148253 0.042565974747467254 0.045215267590761936 0.29641080423358385 0.20320719855121624 0.12244773708564184 TG 16:0_18:1_19:1 0.015156307273214426 0.012278660406978378 0.014700606 0.014229693640580405 0.013431061546017021 0.014764732784245163 TG 16:0_18:1_20:1 0.081362256 0.066085383 0.072348902 0.089822224 0.076642771 0.089021285 TG 16:0_18:1_22:1 0.015340802667000053 0.011133363919215496 0.012191311 0.017165031675578268 0.013670106279960048 0.016370798 TG 16:0_18:1_22:3 0.028762297 0.025873515655997575 0.029501625 0.052478568 0.042522334 0.03556146 TG 16:0_18:1_22:5 0.007671932 0.005406348 0.006970136 0.016817909 0.012627775770176392 0.008181408 TG 16:0_18:1_22:6 0.003235674 0.002435492 0.003031993 0.004410034 0.004035887 0.003561797 TG 16:0_18:1_24:1 0.004826721 0.003373961 0.004304456 0.007119619 0.004733225 0.004923 TG 16:0_18:1_24:6 0.006442959 0.005713282 0.006884036 0.00839041 0.007680326 0.006490359 TG 16:0_18:1_26:1 0.002190383 0.001392493 0.00178994 0.002306784 0.001229111 0.001320295 TG 16:0_18:1_28:5 0.001155749 8.819942806135603e-4 0.001157826 0.001086052 7.547640692571385e-4 6.930761806843139e-4 TG 16:0_24:0_18:1 0.00121478 6.557032844657465e-4 8.718353768217881e-4 0.001251837 8.531204198402223e-4 9.287466565551659e-4 TG 16:0_25:0_16:1 1.0341471091679575e-4 0 0 5.1104302842691006e-5 5.701768992684873e-5 5.2168985322614745e-5 TG 16:1_16:1_17:1 1.654399224636887e-4 0 3.68965518959613e-6 0.001540461 7.602148673050569e-4 3.2342731348084024e-4 TG 16:1_16:1_18:1 0.009554616 6.970373722586451e-4 0.001015516 0.1129520011674667 0.051672585 0.021670534201802448 TG 16:1_16:1_18:2 2.5355322160638223e-4 1.237973511035991e-4 8.618116349304722e-5 0.005858986 0.002499235 4.1348921076787994e-4 TG 16:1_16:1_20:4 3.1525388699739354e-5 1.7743527648585275e-5 1.6517135457168317e-5 4.8213602342553113e-4 1.786263933239816e-4 7.82628980188682e-5 TG 16:1_16:1_22:5 6.151362431696379e-5 2.8030785755427054e-5 0 3.8880319587308805e-4 1.2940048721596617e-4 0 TG 16:1_17:1_18:1 0.002136686 0.001269943 0.001376568 0.008435577 0.005291601 0.002958167 TG 16:1_18:1_16:2 2.056664363060548e-4 5.573972410165102e-5 1.2441730818380986e-4 0.003988056 0.001910173 5.515148067835432e-4 TG 16:1_18:1_18:2 0.005238796 0.0023124 0.00260045 0.070309658 0.032714452248011866 0.013527835989824244 TG 16:1_18:1_20:4 6.802995171198148e-4 4.120122576257849e-4 3.1170089252439525e-4 0.002866832 0.001584842 7.812638029387686e-4 TG 16:1_18:1_21:3 0.001144052 8.889850159421634e-4 9.7750213182685e-4 0.002479625 0.001953029 0.001163219 TG 16:1_18:1_22:5 7.458378981006843e-4 3.944473042680814e-4 4.803808481095867e-4 0.003014879 0.001854771 0.001145447 TG 16:1_18:1_22:6 5.181204294539047e-4 3.2283970310052735e-4 3.7566889374807745e-4 0.002089439 0.001390565 9.08518909462052e-4 TG 16:1_18:2_18:2 2.210754607528967e-4 0 8.47391814400445e-5 0.006127106 0.00212284 6.259772509685317e-4 TG 17:0_18:0_18:1 0.002699564 0.001973158 0.00247418 0.001753413 0.001621295 0.00207366 TG 17:0_18:1_20:1 0.003942327 0.003252772 0.003787143 0.002541779 0.002421351 0.003157296 TG 17:1_18:1_18:1 0.00838608 0.006969829 0.007627736 0.016831644473070267 0.014133360404951858 0.010809382633220373 TG 17:1_18:1_18:2 0.001733977 0.001083538 0.00119886 0.004840559 0.003467486 0.001972727 TG 18:0_18:1_18:1 7.886743181810785e-4 5.870651186494261e-4 7.146776465703497e-4 0.002337257 0.001798199 0.001350402 TG 18:0_18:1_24:6 0.00283839 0.0031387 0.003841121 0.002842061 0.002457489 0.002158042 TG 18:0_22:0_22:0 0 0 0 0 0 1.0644597899524073e-5 TG 18:1_18:1_18:1 0.11665676664450877 0.1171824794940247 0.11692696040004666 0.19228135043678574 0.1632859621139035 0.13985271347992745 TG 18:1_18:1_18:2 0.033836537 0.023747383 0.025889896121873524 0.12069571341109453 0.086013168 0.049917278 TG 18:1_18:1_19:1 0.010099267590771906 0.008246562 0.009947001 0.008863432 0.008676487 0.010015426 TG 18:1_18:1_20:1 0.045809258 0.037201808099549864 0.040754106739265335 0.058053498 0.04853565 0.054853879 TG 18:1_18:1_20:3 0.014375728 0.012416440607691237 0.014716859259966256 0.04137717 0.029062509243949354 0.017742796273477343 TG 18:1_18:1_21:3 0.001450339 0.001549537 0.001720464 0.001726914 0.001450421 0.001035862 TG 18:1_18:1_22:3 0.011380700849869288 0.009628251 0.012008161423444776 0.017377704805474313 0.014739947350119997 0.011366353 TG 18:1_18:1_22:4 0.006499559 0.006892337 0.008380957 0.012941393779206388 0.010625665197699984 0.007168686 TG 18:1_18:1_22:6 0.00297177 0.002066833 0.002649946 0.003441957 0.003955229 0.002948954 TG 18:1_18:1_24:1 0.003858212 0.002776504 0.003536728 0.005952406 0.003894438 0.004079384 TG 18:1_18:1_24:6 0.002495538 0.002432899 0.003111512 0.002741784 0.002611144 0.002644463 TG 18:1_18:1_26:1 0.001341763 8.408121533369178e-4 0.001154407 0.001629355 0.001188907 0.001323623 TG 18:1_18:1_26:5 0.001652882 0.001327797 0.001735991 0.001086607 8.938286869566655e-4 8.529436145491959e-4 TG 18:1_18:1_28:5 5.695228182843778e-4 4.2901708065950253e-4 5.411469998778681e-4 2.3897104281878306e-4 2.3337166803321096e-4 2.3425792811407922e-4 TG 18:1_18:1_28:6 5.778659604763789e-4 4.567047831441082e-4 6.387372818716754e-4 0 0 0 TG 18:1_18:2_18:2 0.003601025 0.001832398 0.001789128 0.015812555003437468 0.00928606 0.003915068 TG 18:1_18:2_21:3 6.602462798857489e-4 5.73903848673428e-4 7.193211659163808e-4 0.001002188 8.794209156285091e-4 5.926102810922893e-4 TG 18:1_18:2_22:6 2.6385115653938796e-4 1.3919969395636176e-4 1.5692548144624998e-4 7.423830379338039e-4 5.454016818362545e-4 3.2154384715587955e-4 TG 18:1_19:1_20:1 0.002513199 0.002163395 0.002441419 0 0 0.002203722 TG 18:1_19:1_20:2 0.002431287 0.002130607 0.002580753 0.002502712 0.002286156 0.002256687 TG 18:1_19:1_22:1 6.535464515319894e-4 5.642911739109829e-4 7.088154453218241e-4 6.718866326523228e-4 5.114661592054588e-4 5.34945942667989e-4 TG 18:1_19:1_22:2 6.612651412980093e-4 5.204050595533364e-4 6.507279588725246e-4 5.319803650298006e-4 4.8698531580445393e-4 5.146751503820751e-4 TG 18:1_19:1_22:3 7.056510984589719e-4 6.310957471822418e-4 8.406094625317217e-4 6.491685564164694e-4 5.648557631393936e-4 5.367829118668141e-4 TG 18:1_20:1_20:1 0.010354678967231034 0.007534378 0.008445288 0.014219216892919734 0.010764777308241828 0.011473589297269219 TG 18:1_20:1_20:2 0.010640138022498042 0.008494708 0.009786373 0.015265863399112735 0.011888480293043164 0.011006169783386375 TG 18:1_20:1_22:2 0.002932955 0.002172877 0.002463244 0.004131999 0.003089959 0.002726917 TG 18:1_20:1_24:3 9.234290848612287e-4 6.825204545192043e-4 7.880304973628312e-4 0.001023617 7.488111457396239e-4 6.507907875241655e-4 TG 18:1_20:1_24:6 9.060811106502021e-4 0.001072422 0.00136619 5.431437360743461e-4 5.676616484226128e-4 4.800466444351054e-4 TG 18:1_20:1_26:1 0 1.2823564618183843e-4 0 2.2170969251254362e-4 1.6384058305053648e-4 1.7090338950764104e-4 TG 18:1_20:2_22:2 0.003622809 0.002786236 0.003438242 0.004171516 0.003285795 0.00288269 TG 18:1_20:2_22:3 0.003600412 0.003039251 0.004083766 0.004335661 0.00375503 0.003001663 TG 18:1_24:1_20:2 9.665692545214633e-4 8.009458221093823e-4 9.586377434362401e-4 0.001399559 0 0 TG 18:1_26:1_20:2 1.8769102042813775e-4 1.0590489663327461e-4 1.9977080762206153e-4 2.3593110974827534e-4 1.6513604636431058e-4 1.4555721547936004e-4 TG 18:2_18:2_18:2 4.5369263687777367e-4 2.2220764332805292e-4 5.035158258651367e-5 0.002020735 8.968867228565399e-4 0 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Average Rt(min) Average Mz CE 16:0 21.89 642.6189 CE 16:1 21.107 640.60394 CE 17:1 21.535 654.61841 CE 18:1 21.872 668.63354 CE 18:2 21.238 666.61951 CE 18:3 20.366 664.60266 CE 20:1 22.361 696.66473 CE 20:3 21.373 692.63556 CE 20:4 20.72 690.61865 CE 20:5 19.712 688.60382 CE 22:2 22.397 722.68262 CE 22:3 21.994 720.66644 CE 22:4 21.484 718.65076 CE 22:5 21.051 716.63574 CE 22:6 20.156 714.61908 CE 24:1 23.03 752.73065 CE 24:2 22.743 750.71271 CE 24:3 22.442 748.69855 CE 24:4 22.069 746.68201 CE 24:5 21.614 744.66522 CE 24:6 21.012 742.65131 CE 26:1 23.274 780.76141 CE 26:3 22.782 776.7287 CE 26:4 22.482 774.71387 CE 26:5 22.131 772.69873 CE 26:6 21.689 770.68231 CE 28:6 22.211 798.71234 CE 30:5 22.834 828.76013 CE 30:6 22.559 826.74371 Cer 17:1;2O/24:1 14.475 634.61377 Cer 18:0;2O/16:0 11.864 540.53601 Cer 18:0;2O/17:0 12.502 554.55103 Cer 18:1;2O/14:0 10.075 510.48849 Cer 18:1;2O/16:0 11.43 538.51935 Cer 18:1;2O/18:0 12.703 566.5506 Cer 18:1;2O/19:0 13.303 580.56677 Cer 18:1;2O/22:0 15.119 622.61322 Cer 18:1;2O/22:1 13.9 620.59778 Cer 18:1;2O/23:0 15.746 636.63049 Cer 18:1;2O/24:0 16.377 650.64612 Cer 18:1;2O/24:1 15.071 648.62866 Cer 18:1;2O/26:1 16.219 676.66077 Cer 18:1;2O/26:2 15.219 674.64478 Cer 18:2;2O/16:0 10.27 536.50391 Cer 18:2;2O/24:0 15.3 648.62988 Cer 18:2;2O/24:1 14.052 646.61316 DG 14:0_18:1 12.549 584.52588 DG 16:0_16:0 13.618 586.54095 DG 16:0_17:1 13.128 598.54144 DG 16:0_18:0 14.558 614.57318 DG 16:0_18:1 13.689 612.55658 DG 16:0_20:1 14.866 640.58807 DG 16:0_22:3 14.327 664.58813 DG 16:0_22:5 12.622 660.55634 DG 16:0_36:4 21.888 858.79272 DG 16:1_16:1 11.509 582.50958 DG 16:1_18:1 12.672 610.54163 DG 16:1_18:2 11.74 608.5246 DG 17:1_18:1 13.285 624.55719 DG 18:1_18:1 13.789 638.57336 DG 18:1_18:2 12.898 636.55579 DG 18:1_20:1 14.927 666.60327 DG 18:1_20:2 13.988 664.5882 DG 18:1_20:3 13.213 662.57233 DG 18:1_22:3 14.362 690.60345 LPC 16:0/0:0 2.475 496.33942 LPC 18:0/0:0 3.616 524.37054 LPC 18:1/0:0 2.65 522.35571 LPC 28:0 9.423 664.52698 LPE 22:6 21.527 526.2937 SM 32:0;2O 8.9 677.56036 SM 32:1;2O 8.438 675.54321 SM 32:2;2O 7.395 673.52771 SM 33:1;2O 9.079 689.56097 SM 34:0;2O 10.223 705.59174 SM 34:1;2O 9.738 703.5743 SM 34:2;2O 8.657 701.5594 SM 36:1;2O 11.079 731.60553 SM 36:2;2O 9.95 729.59186 SM 38:1;2O 12.39 759.63873 SM 39:1;2O 13.007 773.65466 SM 40:1;2O 13.583 787.6709 SM 40:2;2O 12.383 785.6545 SM 41:1;2O 14.171 801.68463 SM 41:4;2O 11.421 795.63129 SM 42:1;2O 14.795 815.7001 SM 42:2;2O 13.556 813.6835 SM 42:3;2O 9.999 811.6703 SM 42:4;2O 11.642 809.65295 SM 43:2;2O 14.137 827.70068 SM 43:5;2O 13.032 821.65063 SM 44:3;2O 13.707 839.70264 TG 10:0_12:0_14:0 15.127 656.5835 TG 12:0_12:0_14:0 16.351 684.61499 TG 12:0_12:0_16:0 17.605 712.64563 TG 12:0_14:0_16:0 18.87 740.67572 TG 12:0_14:0_16:1 17.688 738.66077 TG 14:0_14:0_16:0 20.104 768.7074 TG 14:0_14:0_16:1 18.944 766.69171 TG 14:0_14:1_18:2 18.229 790.69324 TG 14:0_15:0_16:0 20.673 782.72528 TG 14:0_15:0_16:1 19.597 780.70697 TG 14:0_16:0_16:0 21.136 796.73779 TG 14:0_16:0_16:1 20.208 794.7226 TG 14:0_16:0_18:0 21.759 824.77112 TG 14:0_16:0_18:1 21.173 822.75519 TG 14:0_16:0_22:5 20.059 870.75714 TG 14:0_16:0_22:6 19.528 868.73956 TG 14:0_16:1_16:1 19.135 792.7088 TG 14:0_16:1_17:1 19.742 806.72339 TG 14:0_16:1_18:1 20.322 820.73816 TG 14:0_16:1_18:2 19.322 818.72528 TG 14:0_16:1_20:4 18.847 842.72534 TG 14:0_17:1_18:1 20.815 834.75488 TG 14:0_18:1_22:6 19.61 894.75531 TG 14:1_16:1_18:1 19.059 818.72534 TG 14:1_16:1_18:2 18.196 816.70752 TG 15:0_16:0_16:0 21.462 810.75507 TG 15:0_16:0_16:1 20.733 808.73834 TG 15:0_16:0_18:1 21.536 836.77216 TG 15:0_16:0_25:0 23.014 936.89648 TG 15:0_24:0_16:1 22.651 920.86609 TG 16:0_16:0_17:0 21.958 838.7865 TG 16:0_16:0_18:0 22.191 852.80231 TG 16:0_16:0_18:1 21.769 850.78815 TG 16:0_16:0_22:6 20.693 896.77081 TG 16:0_16:1_18:1 21.214 848.76929 TG 16:0_17:0_18:0 22.34 866.81561 TG 16:0_17:0_18:1 21.979 864.80219 TG 16:0_17:1_18:1 21.524 862.78516 TG 16:0_18:0_18:0 22.525 880.83307 TG 16:0_18:0_18:1 22.195 878.81665 TG 16:0_18:0_20:0 22.791 908.86377 TG 16:0_18:0_20:1 22.52 906.84839 TG 16:0_18:0_22:1 22.792 934.88068 TG 16:0_18:0_24:0 23.206 964.92786 TG 16:0_18:1_18:1 21.782 876.80347 TG 16:0_18:1_18:2 21.263 874.78558 TG 16:0_18:1_19:1 21.999 890.81812 TG 16:0_18:1_20:1 22.195 904.83307 TG 16:0_18:1_22:1 22.514 932.86646 TG 16:0_18:1_22:3 21.886 928.83405 TG 16:0_18:1_22:5 21.083 924.80096 TG 16:0_18:1_22:6 20.718 922.78534 TG 16:0_18:1_24:1 22.781 960.8985 TG 16:0_18:1_24:6 21.226 950.81757 TG 16:0_18:1_26:1 22.998 988.93085 TG 16:0_18:1_28:5 22.357 1008.89899 TG 16:0_24:0_18:1 23.01 962.91101 TG 16:0_25:0_16:1 22.901 948.89606 TG 16:1_16:1_17:1 19.902 832.74146 TG 16:1_16:1_18:1 20.501 846.75525 TG 16:1_16:1_18:2 19.39 844.74091 TG 16:1_16:1_20:4 19.023 868.74017 TG 16:1_16:1_22:5 18.932 894.75647 TG 16:1_17:1_18:1 20.96 860.771 TG 16:1_18:1_16:2 19.886 844.74109 TG 16:1_18:1_18:2 20.59 872.77106 TG 16:1_18:1_20:4 20.165 896.77094 TG 16:1_18:1_21:3 21.266 912.80145 TG 16:1_18:1_22:5 20.349 922.78528 TG 16:1_18:1_22:6 19.697 920.77124 TG 16:1_18:2_18:2 19.905 870.75677 TG 17:0_18:0_18:1 22.354 892.83362 TG 17:0_18:1_20:1 22.369 918.84808 TG 17:1_18:1_18:1 21.567 888.80145 TG 17:1_18:1_18:2 21.11 886.78595 TG 18:0_18:1_18:1 21.147 904.83392 TG 18:0_18:1_24:6 21.677 978.85107 TG 18:0_22:0_22:0 23.539 1020.99194 TG 18:1_18:1_18:1 21.81 902.81696 TG 18:1_18:1_18:2 21.349 900.8031 TG 18:1_18:1_19:1 22.008 916.8327 TG 18:1_18:1_20:1 22.198 930.85089 TG 18:1_18:1_20:3 21.543 926.81635 TG 18:1_18:1_21:3 21.753 940.83307 TG 18:1_18:1_22:3 21.972 954.8479 TG 18:1_18:1_22:4 21.599 952.83502 TG 18:1_18:1_22:6 20.76 948.80188 TG 18:1_18:1_24:1 22.775 986.91431 TG 18:1_18:1_24:6 21.306 976.83264 TG 18:1_18:1_26:1 22.983 1014.94592 TG 18:1_18:1_26:5 22.094 1006.88013 TG 18:1_18:1_28:5 22.437 1034.91028 TG 18:1_18:1_28:6 22.125 1032.89832 TG 18:1_18:2_18:2 20.698 898.78491 TG 18:1_18:2_21:3 21.363 938.81769 TG 18:1_18:2_22:6 19.84 946.78894 TG 18:1_19:1_20:1 22.363 944.86499 TG 18:1_19:1_20:2 22.08 942.84894 TG 18:1_19:1_22:1 22.644 972.89807 TG 18:1_19:1_22:2 22.415 970.88116 TG 18:1_19:1_22:3 22.119 968.86298 TG 18:1_20:1_20:1 22.519 958.87964 TG 18:1_20:1_20:2 22.253 956.86639 TG 18:1_20:1_22:2 22.549 984.89911 TG 18:1_20:1_24:3 22.568 1010.91351 TG 18:1_20:1_24:6 21.796 1004.86499 TG 18:1_20:1_26:1 23.18 1042.97583 TG 18:1_20:2_22:2 22.324 982.88257 TG 18:1_20:2_22:3 22.044 980.86719 TG 18:1_24:1_20:2 22.781 1012.92725 TG 18:1_26:1_20:2 23.012 1040.9624 TG 18:2_18:2_18:2 19.756 896.77051 METABOLITES_END #END