#METABOLOMICS WORKBENCH shancock_20250219_170319 DATATRACK_ID:5649 STUDY_ID:ST003758 ANALYSIS_ID:AN006170 PROJECT_ID:PR002341 VERSION 1 CREATED_ON February 20, 2025, 2:22 pm #PROJECT PR:PROJECT_TITLE Untargeted lipidomics of gemcitabine-resistant PDAC cells PR:PROJECT_SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with few PR:PROJECT_SUMMARY treatment options and poor survivability. In this work we sought to characterise PR:PROJECT_SUMMARY metabolic adaptations to gemcitabine (GEMC)-based chemotherapy exposure to PR:PROJECT_SUMMARY discover new therapeutic targets for improving treatment efficacy. We show that PR:PROJECT_SUMMARY GEMC resistance (GEMR) upregulates de novo lipogenesis in Panc1 and MiaPaCa2 PR:PROJECT_SUMMARY cells. PR:INSTITUTE Victor Chang Cardiac Research Institute PR:LAST_NAME Hancock PR:FIRST_NAME Sarah PR:ADDRESS Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW, 20210 Australia PR:EMAIL s.hancock@victorchang.edu.au PR:PHONE +61414537526 #STUDY ST:STUDY_TITLE Untargeted lipidomics of gemcitabine-resistant cells ST:STUDY_SUMMARY In this work we developed gemcitabine (GEMC) resistant (GEMR) PDAC cell lines ST:STUDY_SUMMARY from Panc1 and MiaPaCa2 cells. This dataset contains results and raw data for ST:STUDY_SUMMARY untargeted lipidomics of Panc1 cells, including control (CON), and GEMR cells ST:STUDY_SUMMARY alongside internal quality controls (iQC) and blank samples for background ST:STUDY_SUMMARY subtraction (as described under sample prep). Untargeted lipidomics enabled the ST:STUDY_SUMMARY quantification of more than 400 distinct molecular lipid species within Panc1 & ST:STUDY_SUMMARY MiaPaCa2 control (CON) & GEMR cells from 12 different classes of lipid, with 79 ST:STUDY_SUMMARY molecular species being differentially abundant between MiaPaCa2 control and ST:STUDY_SUMMARY GEMR cells following unpaired t test. Data were analysed using MS-DIAL 4.9. ST:INSTITUTE Victor Chang Cardiac Research Institute ST:LAST_NAME Hancock ST:FIRST_NAME Sarah ST:ADDRESS Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW, 2010, Australia ST:EMAIL s.hancock@victorchang.edu.au ST:PHONE +61414537526 #SUBJECT SU:SUBJECT_TYPE Cultured cells SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - Blank_cells_neg Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_neg.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Blank_cells_neg_20211210204022 Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_neg_20211210204022.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Blank_cells_pos Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_pos.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - Blank_cells_pos_20211210152840 Sample source:Blank | group:Blank RAW_FILE_NAME(Raw file name)=Blank_cells_pos_20211210152840.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_neg Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_neg.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_neg_20211210211133 Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_neg_20211210211133.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_pos Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_pos.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - iQC_cells_pos_20211210155952 Sample source:pool | group:iQC RAW_FILE_NAME(Raw file name)=iQC_cells_pos_20211210155952.mzML; protein amount=- SUBJECT_SAMPLE_FACTORS - MiaPaCa2_CON_1_neg Sample source:MiaPaCa2 cells | group:CON RAW_FILE_NAME(Raw file name)=MiaPaCa2_CON_1_neg.mzML; protein amount=277.5669498 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_CON_1_pos Sample source:MiaPaCa2 cells | group:CON RAW_FILE_NAME(Raw file name)=MiaPaCa2_CON_1_pos.mzML; protein amount=277.5669498 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_CON_2_neg Sample source:MiaPaCa2 cells | group:CON RAW_FILE_NAME(Raw file name)=MiaPaCa2_CON_2_neg.mzML; protein amount=222.8989234 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_CON_2_pos Sample source:MiaPaCa2 cells | group:CON RAW_FILE_NAME(Raw file name)=MiaPaCa2_CON_2_pos.mzML; protein amount=222.8989234 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_CON_3_neg Sample source:MiaPaCa2 cells | group:CON RAW_FILE_NAME(Raw file name)=MiaPaCa2_CON_3_neg.mzML; protein amount=252.7464251 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_CON_3_pos Sample source:MiaPaCa2 cells | group:CON RAW_FILE_NAME(Raw file name)=MiaPaCa2_CON_3_pos.mzML; protein amount=252.7464251 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_GEMR_1_neg Sample source:MiaPaCa2 cells | group:GEMR RAW_FILE_NAME(Raw file name)=MiaPaCa2_GEMR_1_neg.mzML; protein amount=239.1103887 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_GEMR_1_pos Sample source:MiaPaCa2 cells | group:GEMR RAW_FILE_NAME(Raw file name)=MiaPaCa2_GEMR_1_pos.mzML; protein amount=239.1103887 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_GEMR_2_neg Sample source:MiaPaCa2 cells | group:GEMR RAW_FILE_NAME(Raw file name)=MiaPaCa2_GEMR_2_neg.mzML; protein amount=244.7938146 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_GEMR_2_pos Sample source:MiaPaCa2 cells | group:GEMR RAW_FILE_NAME(Raw file name)=MiaPaCa2_GEMR_2_pos.mzML; protein amount=244.7938146 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_GEMR_3_neg Sample source:MiaPaCa2 cells | group:GEMR RAW_FILE_NAME(Raw file name)=MiaPaCa2_GEMR_3_neg.mzML; protein amount=250.0487649 SUBJECT_SAMPLE_FACTORS - MiaPaCa2_GEMR_3_pos Sample source:MiaPaCa2 cells | group:GEMR RAW_FILE_NAME(Raw file name)=MiaPaCa2_GEMR_3_pos.mzML; protein amount=250.0487649 #COLLECTION CO:COLLECTION_SUMMARY Samples were obtained from established immortalised adherent human pancreatic CO:COLLECTION_SUMMARY ductal adenocarcinoma cells (MiaPaCa2). Cells were cultured in high glucose DMEM CO:COLLECTION_SUMMARY containing 4.5 g/L glucose and 4 mM glutamine and were supplemented with 10% CO:COLLECTION_SUMMARY FCS. Cells were cultured under 5% CO2 at 37ºC and routinely passaged every 2-3 CO:COLLECTION_SUMMARY days (when ~80-90% confluent). Cell lines were regularly screened for mycoplasma CO:COLLECTION_SUMMARY infection. CO:SAMPLE_TYPE Pancreas #TREATMENT TR:TREATMENT_SUMMARY MiaPaCa2 GEMR cells were produced by serial treatment with escalating doses of TR:TREATMENT_SUMMARY gemcitabine for approximately 12 weeks. The final concentration of GEMC for TR:TREATMENT_SUMMARY Panc1 cells was 64 nM, resulting in a half-maximal inhibitory concentration of TR:TREATMENT_SUMMARY 92.2 nM (approximately 3x increase over control (CON) cells, 30.6 nM) #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Lipids were extracted from cells grown to 80-90% confluency in 6 well plates SP:SAMPLEPREP_SUMMARY using a modified methyl tert-butyl ether (MTBE) method. Adherent cells were SP:SAMPLEPREP_SUMMARY washed with ice-cold PBS and scraped into methanol containing 0.01% butylated SP:SAMPLEPREP_SUMMARY hydroxytoluene and 100 pmol each of internal standards (phosphatidylcholine SP:SAMPLEPREP_SUMMARY 19:0/19:0, phosphatidylethanolamine 17:0/17:0, phosphatidylserine 17:0/17:0, SP:SAMPLEPREP_SUMMARY lysophosphatidylcholine 17:0, lysophosphatidylethanolamine 14:0, SP:SAMPLEPREP_SUMMARY phosphatidylglycerol 17:0/17:0, phosphatidic acid 17:0/17:0, ceramide SP:SAMPLEPREP_SUMMARY d18:1/17:0, dihydrosphingomyelin 12:0, cholesteryl ester 22:1, diacylglycerol SP:SAMPLEPREP_SUMMARY 17:0/17:0, D5-triacylglycerol 16:0/16:0/16:0 and cardiolipin SP:SAMPLEPREP_SUMMARY 14:0/14:0/14:0/14:0). An empty well was also scraped for use in background SP:SAMPLEPREP_SUMMARY subtraction. To this, MTBE was added at a ratio of 3:1 v/v, and extracts were SP:SAMPLEPREP_SUMMARY rotated overnight at 4ºC. Following overnight rotation, 1 part of ice-cold 150 SP:SAMPLEPREP_SUMMARY mM ammonium acetate was added, samples were vortexed vigorously and centrifuged SP:SAMPLEPREP_SUMMARY at 2000 x g for 5 min. The upper organic phase containing lipids was transferred SP:SAMPLEPREP_SUMMARY into a 1.5 mL autosampler vial and dried under N2 at 37ºC Dried lipids were SP:SAMPLEPREP_SUMMARY reconstituted in chloroform:methanol:water (60:30:4.5 v/v/v), transferred to a SP:SAMPLEPREP_SUMMARY sleeved vial, and stored at -20ºC until analysis. The aqueous phase containing SP:SAMPLEPREP_SUMMARY the protein pellet was dried under N2 and digested with 1M NaOH overnight at SP:SAMPLEPREP_SUMMARY 4ºC. Digested protein was diluted 1:2 v/v with water and protein concentration SP:SAMPLEPREP_SUMMARY was determined using a Pierce BCA assay kit (ThermoFisher Scientific) #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Waters ACQUITY UPLC CSH C18 (100 x 2.1mm,1.7um) CH:SOLVENT_A Acetonitrile:water (3:2 v/v), 10 mM Ammonium Formate, 0.1% Formic acid CH:SOLVENT_B Acetonitrile:isopropanol (1:9 v/v), 10 mM Ammonium Formate, 0.1% Formic acid CH:FLOW_GRADIENT As described by Hu et al. 2008 J Proteome Research CH:FLOW_RATE 0.26 ml/min CH:COLUMN_TEMPERATURE 60 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive HF hybrid Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Source conditions were as follows: a spray voltage 4.0 kV in positive ion mode MS:MS_COMMENTS and 3.5 kV in negative ion mode, capillary temperature 290°C, S lens RF 50, and MS:MS_COMMENTS auxiliary gas heater temperature of 250°C. Nitrogen was used as both source and MS:MS_COMMENTS collision gas, with the sheath gas flow rate set at 20 and the auxiliary gas MS:MS_COMMENTS flow rate at 5 (arbitrary units). Data were acquired in full scan/data-dependent MS:MS_COMMENTS MS2 mode (full-scan resolution 70,000 FWHM, max ion injection time 50 ms, scan MS:MS_COMMENTS range m/z 200–1,500), with the 10 most abundant ions being subjected to MS:MS_COMMENTS collision-induced dissociation using an isolation window of 1.5 Da and a MS:MS_COMMENTS normalized stepped collision energy of 15/27 eV. Product ions were detected at a MS:MS_COMMENTS resolution of 17,500. An exclusion list for background ions was developed using MS:MS_COMMENTS extraction blanks, and mass calibration was performed in both positive and MS:MS_COMMENTS negative ionization modes before analysis to ensure mass accuracy of 5 ppm in MS:MS_COMMENTS full-scan mode. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS nmol/mg protein MS_METABOLITE_DATA_START Samples MiaPaCa2_CON_1_pos MiaPaCa2_CON_2_pos MiaPaCa2_CON_3_pos MiaPaCa2_GEMR_1_pos MiaPaCa2_GEMR_2_pos MiaPaCa2_GEMR_3_pos Factors Sample source:MiaPaCa2 cells | group:CON Sample source:MiaPaCa2 cells | group:CON Sample source:MiaPaCa2 cells | group:CON Sample source:MiaPaCa2 cells | group:GEMR Sample source:MiaPaCa2 cells | group:GEMR Sample source:MiaPaCa2 cells | group:GEMR CE 14:0 0.14798770793070978 0.16522123308310913 0.18733329786155917 0.078847511 0.069763918 0.057243501 CE 16:0 0.23987574121423932 0.35278628234554665 0.29306908059653486 0.16933946779712233 0.12683247284983332 0.091997092 CE 16:1 0.4937253684303838 0.6476744889659062 0.6689516888792238 0.3837244342502429 0.38711969549806785 0.33644867708436266 CE 17:0 0.063017019 0.080581425 0.073166792 0.057277065 0.043841677 0.046481393450449236 CE 17:1 0.11629265878497572 0.14623435866831144 0.1247204469480388 0.10829880407005647 0.11009249592276875 0.098120813 CE 18:0 0.085390611 0.10621182400818978 0.072691807 0.068364973 0.11880380014781204 0.067801583 CE 18:1 3.735565690130216 3.694599823540443 4.234324177939047 2.4764339569648004 3.54639395 2.7788826192043024 CE 18:2 0.4087962081278096 0 0.5534261221616322 0.4799305526109276 0.41117564233641873 0.4675181167746466 CE 18:3 0.16348956454794258 0.1547354546187575 0.16596258533505687 0.12660532248669204 0.17972373323187402 0.16315383698558233 CE 19:1 0.16689264306107474 0.14835030604672542 0.18184488133151597 0.13912635942088863 0.18515554699065373 0.16794436883730213 CE 19:2 0.11037560906296615 0.11170854145468645 0.1085155783360863 0.09950959 0.15085004425485138 0.13305137134701936 CE 20:1 0.6323752339215399 0.6655095757079263 0.6717463382460606 0.6072560582936805 0.8985229458939266 0.5791818328906075 CE 20:2 0.1985622199566691 0.22665753295913083 0.2098114643323926 0.21977990430574804 0.2780230444960419 0.25851567935661746 CE 20:3 0.6185208218238436 0.9364383832601382 0.7061370977964067 0.6927567722372683 0.6049410808498695 0.5015337054029108 CE 20:4 0.8132273165630053 0.8674921830991064 0.8731875740220956 0.977059765 1.3162633262864571 1.137745135847802 CE 20:5 0.23736996297183519 0.19636641969196658 0.2448856967291361 0.206036799 0.3408722365912559 0.27631268811877735 CE 22:2 0.08813549 0.08627104 0.080890333 0.10135606446873861 0.13182142472836814 0.10516036351784099 CE 22:3 0.16989613520076413 0.1892517783652901 0.15825686544038828 0.20750079184625717 0.17589128398265577 0.14225561129024966 CE 22:4 0.5409760515557822 0.3850094805334919 0.38022620507288485 0.5641834099633062 0.7956649468807033 0.6061878603787404 CE 22:5 0.677359392 0.3621102815867603 0.3851494888986198 0.3961688115044339 0.9086394410811112 0.6262147952714892 CE 22:6 1.5665600751472126 1.480607423502424 1.0884274772477263 1.5762475358888566 1.9378519385662787 1.425387191639235 CE 24:0 0.052492465 0.06344754 0.051506399 0.042964051 0.061152652 0.060930013 CE 24:1 0.7563048659025432 0.8770166907407771 0.8701992903482368 0.6314467698513305 0.87366954 0.7051426625147785 CE 24:2 0.26664137512296227 0.291453365 0.2886332398342122 0.3557526689687335 0.46430124675740886 0.43860170239943685 CE 24:3 0.17968342708948404 0.23492627306494926 0.19596011455915233 0.2494319156075061 0.23689632061408997 0.1995924206548558 CE 24:4 0.39453047855116086 0.4299056703182204 0.41816241422906597 0.5999413331485858 0.5675112388940723 0.4315132456868934 CE 24:5 1.3549112780368384 0.9778777954700529 1.1071791179069643 0.608707517 0.8689386402748838 0.6442971612834035 CE 24:6 0.23731718475165636 0.21274309870128924 0.20848631243613694 0.20451769904407546 0.18048729600483893 0.14491101649451252 CE 26:0 0.2583182791873029 0.2215003887615802 0.16428832003848873 0.13297567422397294 0.15808538209256096 0.1530379529198894 CE 26:1 1.3964788811693027 1.8217933365693129 1.5573776023310006 1.2361215771177654 1.2029805914846832 1.2177051821158504 CE 26:2 0.6639464775875339 0.8023773091689294 0.7317132226303665 0.7474925119620034 1.118093292024167 0.9997368046914794 CE 26:3 0.28999271073878446 0.49595194003664994 0.33969260129215134 0.4353244679468553 0.30297929387834227 0.3025132243813563 CE 26:4 0.36524619509689443 0.641927465 0.45426926009383706 0.8413145966568231 0.4917803695762091 0.44342700978799343 CE 26:5 0.4811614249572106 0.816486863 0.5295015963403165 0.4518485127254417 0.2771247391564821 0.27592539364988383 CE 26:6 0.20194059026961955 0.32807589324889813 0.14172365329357656 0.2354446795431167 0.12060522999217949 0.1000333992734239 CE 28:0 0.037048336 0.034581583 0 0 0 0 CE 28:1 0.4011366190530238 0.40999521006081596 0.30941049133838733 0.25074800240325706 0.21776924780563003 0.23661161120829655 CE 28:2 0.086652928 0.1251244043226988 0.10038447998250545 0.090428309 0.096796249 0.094279288 CE 28:3 0.04972654 0.08718857 0.061319157786826346 0.052632644 0.037938029 0.033350029 CE 28:4 0.049803262 0.11488819546072469 0.067239758 0.10381975152884461 0.060970817 0.061285681910556465 CE 28:5 0.086046936 0.14642540348667238 0.097321392 0.075752894 0.033787637 0.031229878 CE 30:5 0.061496277 0.072133136 0.060317758 0.018064866097769416 0.028389767161998022 0.031534015451025084 Cer 17:1;2O/16:0 0.049665848 0.062992815 0.079801924 0.048787109 0.050510107 0.04645461 Cer 17:1;2O/22:0 0.036396261460857254 0.032781431 0.053703226712799576 0.050466911 0.05343907 0.045334009111776714 Cer 18:0;2O/16:0 0.14476051065192702 0.1491555681446765 0.16082719298721945 0.16922861177499687 0.20834230621163172 0.17119469664946077 Cer 18:0;2O/18:0 0.024453891217730464 0.018821191996242836 0.021406087869169494 0.024742089080853458 0.043480713 0.027195151 Cer 18:0;2O/22:0 0.022641958819747492 0.025528413061147778 0.032950596 0.033716271088754524 0.034499368 0.028206103691025376 Cer 18:0;2O/24:1 0.056171972 0.05801642 0.092951321 0.076828667 0.070729722 0.058381108 Cer 18:1;2O/14:0 0.038383802490270104 0.036830177723269866 0.037117487220212644 0.037103288 0.035344159121255936 0.026107941773714706 Cer 18:1;2O/16:0 1.8615006774219875 2.103848533359237 2.220926685994383 2.038353831066836 2.2581217551016133 1.9605747471410166 Cer 18:1;2O/18:0 0.5042517582826063 0.49885904122985475 0.5734513621537323 0.7012614340526392 0.9087106867086209 0.7010999505376877 Cer 18:1;2O/20:0 0.11368325114461247 0.13329926439529766 0.15500514 0.17584138255374832 0.20433717167833276 0.16112749499005494 Cer 18:1;2O/22:0 0.3537058962571531 0.39614742041325707 0.47417640730058735 0.5020275803034414 0.6152159960702512 0.4704619995557185 Cer 18:1;2O/22:1 0.1468529800637045 0.17934906966876013 0.1938283781561848 0.17173632048994142 0.17550545065260065 0.13577280669583225 Cer 18:1;2O/23:0 0.091236913 0.10058106213841751 0.10958690099063799 0.11123338511999664 0.1226728454338345 0.094457136 Cer 18:1;2O/23:1 0.07681038 0.084734902 0.094921843 0.08749754 0.091232683 0.066460275 Cer 18:1;2O/24:0 1.0645063039555245 1.090278854209176 1.1724936816140135 1.2132427493116558 1.564505176 1.180603440615287 Cer 18:1;2O/24:1 2.1793415124010163 2.4424951260095247 2.8381925333359233 2.8922328687117758 3.1404310115297074 2.438333475568852 Cer 18:1;2O/25:0 0.021943299 0.024552071143286225 0.027984360803817505 0.024652748127867535 0.024621146319658695 0.020183852124355053 Cer 18:1;2O/25:1 0.031259873 0.035035899 0.037936852 0.034141154 0.033422921 0.026411148873379055 Cer 18:1;2O/26:0 0.049566649 0.061069597 0.057881252404671166 0.057847302897016395 0.069334942 0.055716032 Cer 18:1;2O/26:1 0.12380181106557124 0.15156304516790223 0.15512831579011985 0.14479491530978314 0.13526594990605495 0.10746998675237598 Cer 18:2;2O/16:0 0.080347278 0.08626139 0.094947003 0.063057934 0.063909088 0.052733904 Cer 18:2;2O/18:0 0.056639779 0.044749767 0.048764935 0.056120209 0.067073562 0.043093926 Cer 18:2;2O/24:1 0.3783038686634409 0.3891362627041604 0.4368140937646526 0.34776118075233453 0.40648257889155115 0.26868132640063874 Cer 18:2;2O/26:1 0.029170436509573284 0.038095430796408244 0.042806685 0.027603874057504738 0.026226516 0.020538321 DG 14:0_16:1 0.032431674045654356 0.1135687558530476 0.074506592 0.083763029 0.038964802 0.057035033 DG 14:0_36:4 0.098326275 0.038157936675599254 0.045537652 0.051569202017339104 0.053694219 0.045839662 DG 16:0_16:0 0.5522376533001475 0.81537302 0.6921044292194758 0.6593811902784021 0.3413506833989392 0.3982477197576651 DG 16:0_16:1 0.959796423 1.8472560998620413 1.5298720080989272 1.6943833551063547 0.9915502392437398 1.2163239416068898 DG 16:0_17:1 0.029757989409951818 0.048486211 0.044049515257952726 0.056523846993168446 0.036856972 0.042175943 DG 16:0_18:0 0.1426089877138792 0.1944816188431262 0.16215700206363168 0.18730871151731396 0.1460176119342815 0.14494653959347373 DG 16:0_18:1 2.7432822072313825 4.735003549521724 4.4637185521133675 5.440555247694316 3.4282430324863467 4.272235009513952 DG 16:0_22:1 0.062972664 0.074446923 0.08207637 0.12199571146980145 0.081402113 0.082781397 DG 16:0_22:5 0.060216636 0.070154551 0.072816025 0.10153732149407758 0.09327108 0.087114 DG 16:0_24:1 0.074690045 0.10257588904395216 0.092187397 0.13737763175837125 0.060380087 0.06687669 DG 16:0_26:0 0.033618205 0.034336008 0.030022660407884698 0.032150887592352094 0.020125035174572824 0.022265346696426443 DG 16:0_26:1 0.1100505728225715 0.1107729971445101 0.10940035696549098 0.12854840677617982 0.053260781195027175 0.057843834380469444 DG 16:0_36:4 0.40154435164403085 0.2575758018508164 0.32341584924384775 0.2997700063330148 0.26785368966186573 0.27692654263462985 DG 16:1_16:1 0.054667908871016434 0.13408887273392944 0.1090930433656824 0.13473536666971336 0.097517291 0.11417039927898333 DG 16:1_18:1 1.0382562241253028 2.0765044282239673 1.884310575761673 2.6212204920328133 1.8753668141773365 2.2283653968812036 DG 17:0_18:1 0.058638378 0.10103077309312618 0.098111664 0.1593588409392937 0.090922402 0.11223554323704264 DG 17:1_18:1 0.052852047027525516 0.10015462 0.096985925 0.1417655284849421 0.11094383182505657 0.13124062651182555 DG 18:0_18:0 0.023875629 0.023558872 0.021029082665128835 0.033331222 0.041009318 0.036670541 DG 18:0_18:1 0.660083776 0.8999733021065807 0.9272492677263898 1.371154659147038 1.1058223744790276 1.265548763364656 DG 18:1_18:1 1.7832172683739427 3.2077804185620162 3.440962567003036 5.489252829904878 4.225241868833167 5.405822672379425 DG 18:1_18:2 0.1617104590069155 0.25520234516440665 0.2352855827193547 0.37136536744065024 0.35228669394197226 0.3318343238515623 DG 18:1_19:1 0.03327246 0.053699251 0.057303012 0.10767874323075916 0.069620457 0.080302015 DG 18:1_20:1 0 0 0.44244901277128873 0.9289063418184034 0.5624536514535252 0.7786207395278418 DG 18:1_20:2 0 0.060560663799799325 0.064342458 0.11910397318998232 0.078711813 0.096767699 DG 18:1_22:1 0.060439782 0.090364377 0.10285692434063137 0.20271244171582406 0.10923977880318979 0.1309950843133238 DG 18:1_24:1 0.090248024 0.14381182053506067 0.14950981191250612 0.2794427645988424 0.13418892362424692 0.17816171506334139 DG 18:1_26:1 0.092432917 0.10427806354176652 0.12279215396060351 0.23709731865839007 0.12893069456004216 0.1512125110482133 DG 18:1_28:1 0 0 0.01645105 0.031238831812478482 0 0.023848952910123504 DG 26:0_18:1 0.039387707 0.056142914 0.042565522 0.098828973 0.068430245 0.078595442 LPC 16:1 0.029796631 0.086858976 0.025608637045287406 0.051944695122876486 0.05488334 0.040052526 LPC 18:0/0:0 0.11195096240073699 0.10568542155884707 0.085301846 0.092731783 0.16544660875430556 0.12407392158369888 LPC 18:1 0.22632186913670135 0.44194153371614836 0.2023598211581635 0.37941790957521415 0.4660368627670544 0.3563610540818703 LPC 20:1/0:0 0.018826464 0.022315655589471132 0.017804565460013435 0.020263701682337255 0.027184763 0.020775774928601127 LPC 24:1/0:0 0.045345516 0.034488855191075585 0.042706842 0.04466885 0.072091596 0.056608891 LPC 26:1/0:0 0.1828816730243103 0.13542505589715922 0.15345418409855774 0.15523247908224352 0.15716629521972672 0.14070189872424757 LPC 28:0 0.763406745 0.9764295659590441 0.767821823 0.7259757606948324 0.620805579 0.6362373838507196 LPE 16:0 0.14345311752655082 0.1145371662015879 0.093652246 0.060115133 0.096868712 0.078525 LPE 16:1 0.034600046 0.049626954336245456 0.023599331501235637 0.025822343814008653 0.039086091569735255 0.031190850862120995 LPE 18:0 0.37260398624954816 0.252024297 0.23525478472202208 0.17467465310539773 0.3578404693203337 0.29106171286708044 LPE 18:1 0.5215551150124337 0.6367455945847658 0.081073447 0.41571312160428103 1.2177846576532885 0.5557905166741868 LPE 20:4 0.035851816 0.088113083 0 0.081326327 0.12541157319647545 0.087729635 LPE 22:5 0.013477027094935076 0.032770266213669144 0.012144167985287207 0.034813248 0.056917914 0.036256122 LPE 22:6 0.091360716 0.31282725694884234 0 0.2712381618405143 0.3196157133581948 0.15322838616459752 LPE 24:0 0.2926753899447612 0.15386113155212847 0.2120685712824383 0.16572441580006644 0.3508163996910285 0.2777066991545178 SM 30:1;2O 0.007424431 0.011192072953464268 0.011353734160551852 0.010052135144254237 0.010638474436104571 0.009382577 SM 32:1;2O 0.8239900790698373 0.7865204828486765 0.7870572837716313 0.8029140092070803 0.8497406600825669 0.8436850639987633 SM 32:2;2O 0.036860231 0.049767536 0.044104654 0.039278789646554554 0.048968893 0.045657465 SM 33:1;2O 1.0975030052874981 1.243346730566934 1.015732800752758 0.9060997258301249 1.0269914696469533 1.029883564780456 SM 34:0;2O 0.6908944337692431 0.643674987 0.5706934046390778 0.7515282783427846 0.7361525217479666 0.7674850807560942 SM 34:1;2O 23.241713770358007 28.69369431107506 24.830488018552963 23.128534998110162 23.590687987686593 25.531217640881106 SM 34:2;2O 1.6497120589160097 1.6614599119706337 1.7374705636449523 1.3698107992503878 1.4587315034204145 1.4663939201673444 SM 36:1;2O 2.053580003139659 2.675355067112844 2.4316701306329427 3.8070384394844683 4.465495150431094 3.241170647120526 SM 36:2;2O 0.6755906173237836 0.7077941919832597 0.6410684484753154 0.7495932459931691 0.9859114407000585 0.9496127648666575 SM 38:1;2O 0.2366013899809865 0.22626665372975235 0.2003306755740845 0.3013311351024181 0.4004227372368839 0.32068172421775165 SM 38:2;2O 0.073289877 0.09065881 0.070064926 0.086718147 0.12918637103697633 0.098159181 SM 40:0;2O 0.022666666744073638 0.026248010963357698 0.022846399919755227 0.025608366111062257 0.027330224 0.024618658491746277 SM 40:2;2O 0.6736162089053829 0.6787410834854288 0.599496466 0.6629040154677476 0.6785126236411929 0.6465149594648646 SM 41:1;2O 0.21111230654159618 0.23292753637907979 0.1976267171325254 0.20105168373601548 0.2079657268842158 0.19986242157557918 SM 41:2;2O 0.44874751526720363 0.4236837993209281 0.3707210113138886 0.45083840424037946 0.45854912166297485 0.4138427892256435 SM 42:1;2O 3.304439712822508 3.3648569758565983 2.9778189011916325 3.2031293273079777 3.8807018071066777 3.886565773051475 SM 42:2;2O 0.4728582328268671 0.5069946010206599 0.5017353075455584 0.6065976135816586 0.7064662416821369 0.7672402362080575 SM 42:3;2O 1.8335928411189408 1.7203568297661154 1.5586476547228478 1.845297288585617 1.8800587150066215 1.7843393403541072 SM 44:1;2O 0.094183968 0.1087651679780776 0.093826391 0.07608771 0.095200742 0.09154153 SM 44:2;2O 0.3959279958501967 0.48325676382078114 0.3897838145672229 0.4225078307402947 0.3766786266310468 0.3894404876002233 SM 44:3;2O 0.12046791492387748 0.13196893402758933 0.10753989972080044 0.13300771831369085 0.11618706527174724 0.11279439632025653 TG 10:0_12:0_14:0 0.001611152 0 0.021310998 0 0 0 TG 12:0_12:0_14:0 0.006880062 0 0.015054809600809215 0 0 0 TG 12:0_14:0_14:0 0.011914014890010684 0.001660215 0.010627407589128866 6.53420715020674e-4 0.001590736 0.001108981 TG 12:0_14:0_16:0 0.12554753469725588 0.017669585 0.050917530061744945 0.011622859 0.017199180790150623 0.012387660968900573 TG 12:0_14:0_16:1 0.04212919 0.008641103 0.02037068 0.006490785 0.011161904315023622 0.008478569 TG 12:0_14:0_18:1 0.5215636432223643 0.089401385 0.2253569411962304 0.067541486 0.12822289712535298 0.089718265 TG 12:0_14:1_18:1 0.050206722191063806 0.009919963 0.026430287673263133 0.009142704 0.018853552 0.014934240139434854 TG 12:0_15:0_16:0 0.031533653035096254 0.005579848 0.007950882 0.00385455 0.006388588 0.005297199 TG 12:0_16:0_22:5 0.015512227160407035 0.002634018 0.006515026 0.002630385 0.008173867 0.00465773 TG 12:0_16:1_17:1 0.015112191 0.002390318 0.005637235 0.003117011 0.00663237 0.004574868 TG 12:0_16:1_18:1 0.6841135310105371 0.1404643902868369 0.3282350294024634 0.1370262549768216 0.30078596540772184 0.21292410285278096 TG 14:0_14:0_16:0 0.8253769694800926 0.17166314999420865 0.257467454 0.11064962733679157 0.17965945647616463 0.11516114031199765 TG 14:0_14:0_18:1 0 0.07208024 0.20071591958875867 0.066002784 0 0 TG 14:0_15:0_16:0 0.11789424909479916 0.024151446 0.046585392473432456 0.020857985 0.03205471 0.021682854650473413 TG 14:0_15:0_16:1 0.11550526937931156 0.020901087693987613 0.046880583 0.018658933790325856 0.037331330393856436 0.028788189336749925 TG 14:0_16:0_16:0 3.579491450025049 1.092027084408503 2.1249798368297914 0.6942982103727998 0.9659908599042837 0.5934340607943666 TG 14:0_16:0_16:1 4.305735724487501 0.9100271685095894 1.6360333468241437 0.7888636258792144 1.580005904506894 1.032386827033362 TG 14:0_16:0_17:0 0.4542940685502081 0.10910639674455165 0.1783369271833301 0.098296246 0.13310309260750064 0.090170504 TG 14:0_16:0_17:1 0.5417225159922268 0.10187221323825504 0.22694374751323446 0.10955074340334302 0.22834846941079928 0.14349267640667487 TG 14:0_16:0_18:0 4.425770093049214 1.9785892952121429 2.5053814696111094 1.1543082679497803 1.3447117341074701 0.8248972656150166 TG 14:0_16:0_18:1 17.39761931 5.663279313217979 11.548683011779733 4.786044653262766 8.426426212065218 5.411656122977149 TG 14:0_16:0_22:6 0.038672163814188344 0.005473323 0.014529133361801434 0.004204932 0.012987119280697203 0.007286077 TG 14:0_16:1_17:1 0.1499132202971312 0.021715763464380696 0.067009188 0.026103888 0.075969492 0.058427652 TG 14:0_16:1_18:1 6.996446611717529 1.5791856197249505 3.451257214 1.8242221092064546 4.352693323584211 3.0280735777092347 TG 14:1_16:1_16:1 0.012724725829559864 0.002739047 0.008858873 0.002986506 0.006569097 0.004735199 TG 14:1_16:1_18:1 0.4465415346721793 0.09508916 0.1989486252469845 0.10956545719823511 0.30999092080116947 0.21207111426432007 TG 15:0_16:0_18:1 2.520690873171841 0.5474493448790535 1.1450330965282127 0.6445374146362229 1.2573944053652883 0.8026303339291784 TG 15:0_16:0_24:0 0.019311497274120796 0.004483247 0.002295531 0.004037146 0.006803253 0.00155227 TG 16:0_16:0_16:1 1.6035384485959887 0 0 0.46671668388839516 0 0 TG 16:0_16:0_17:0 0.4584172729725293 0.1626129557961301 0.2496192887315384 0.14373956225401768 0.18724613600176906 0.11819421436693689 TG 16:0_16:0_18:0 3.5104379892384188 1.5388952363463893 2.0534291515427965 0.9719442715349276 1.6589194275098165 0.8874223968270846 TG 16:0_16:0_18:1 22.23851794087213 9.242496152013846 14.187073880849352 7.796247448957218 12.469701487888546 8.155860925836917 TG 16:0_16:0_20:4 0.19174166032518009 0.052541531 0.1056397145635441 0.058949844 0 0.087975377 TG 16:0_16:0_22:6 0.11731862651901524 0.020057977848700462 0.042048750596123535 0.017486222 0.053683276850398504 0.023760888 TG 16:0_16:0_24:0 0.3097697288534074 0.11751915660840356 0.16070121688093855 0.087376286 0.13647424353449245 0.077228931 TG 16:0_16:0_24:1 2.2871419843052316 0.7430618154819997 1.1129540924779837 0.7821782674746927 1.5409029344197573 0.874680476 TG 16:0_16:0_25:0 0.019442896412175004 0.007709144 0.008152754 0.006212848 0.007045808 0.003920899 TG 16:0_16:0_26:1 2.177409866586139 0.8500954110300484 1.2150034911562948 0.8538361008075084 1.4574201917128569 0.9257638887356593 TG 16:0_16:1_16:1 0.3928608534154557 0.097695862 0.23800033489287947 0.12017214019099713 0.27542920050784025 0.16116787227032414 TG 16:0_16:1_17:1 0.8248190361651554 0.1699357794059106 0.33853291322735174 0.22612180137537716 0.6404100543855906 0.40205749509420774 TG 16:0_16:1_18:1 29.68467914658514 9.815135547 21.54235759318164 11.159408225103595 25.173332973478917 17.268125384037315 TG 16:0_16:1_20:4 0.1476688179810403 0.032663668 0.058048991417052956 0.034035242 0.10520742478423994 0.063122108 TG 16:0_16:1_22:6 0.10935368859664671 0.016445850194075445 0.048987784798922795 0.014477717518957496 0.053245232 0.031323918 TG 16:0_17:0_18:0 0.1728608220578692 0.055922719 0.082712943 0.059312313 0.11867385628107505 0.05603735 TG 16:0_17:0_18:1 2.390901445281716 0.7839010009890595 1.4467602362120249 0.9504232422248763 1.8622019062603632 1.186488338039788 TG 16:0_17:0_24:1 0.272636286 0.075847316 0.099764391 0.085022193 0.13900639746532423 0.081262393 TG 16:0_17:1_18:1 4.436891607140417 0.936384437 2.377622470430744 1.373356035289518 4.054209856888234 2.611708117899357 TG 16:0_18:0_18:0 1.2155759066054452 0.3643555187189342 0.4906312779646344 0.354289857 1.336341022608724 0.5431388293662707 TG 16:0_18:0_18:1 14.688769169038313 5.872469736302765 9.497566344 5.555283947 12.773068713178082 7.52231388 TG 16:0_18:0_20:0 0.2838866770122089 0.082559101 0.10813194967068557 0.077975979 0.23561265906144668 0 TG 16:0_18:0_20:1 4.341227204374406 1.3307338800755948 2.0902514587172627 1.820621420607311 5.543580834707468 3.1402041681348694 TG 16:0_18:0_24:0 0.4214792548351217 0.14451638560592428 0.17644041461006663 0.10850626543965586 0.2174903846441699 0.10788382019930967 TG 16:0_18:0_26:0 0.097200892 0.034813734143981805 0.037779869 0.031170833092994853 0.077038102 0.042393692 TG 16:0_18:0_26:1 1.7693314648301628 0.5339631693457134 0.7833500592415414 0.5547584055625915 1.2777463464737449 0.769790195 TG 16:0_18:0_28:0 0.014716425958816722 0.006106824 0.006581885 0.004774304 0.013164118 0.007943115 TG 16:0_18:1_18:1 35.00358912081001 13.484623485033275 24.87418688261556 16.801804237802305 38.503189391412484 26.104002525903482 TG 16:0_18:1_19:1 3.5961397521591176 1.139650198772535 2.3741180745884143 1.82706608 4.8996229801734135 3.204557151039602 TG 16:0_18:1_20:4 0.5960871350027539 0.14332380868122926 0.3293750511307808 0.17319845134309012 0.5618182933746636 0.2981534737388329 TG 16:0_18:1_21:5 0.026107655 0.004351926 0.010612174530718088 0.007224332 0.030589454 0.016079856 TG 16:0_18:1_22:5 0.7333953285682561 0.1654629471419817 0.396909038 0.2438288455379238 0.9078587298144242 0.5205578658029203 TG 16:0_18:1_22:6 0.33960886349683544 0.059687476302064876 0.132065767 0.066485012 0.27056060914334096 0.12466195055961184 TG 16:0_18:1_24:1 5.291564954413388 1.7045190837497632 2.963995820957585 2.5419502905962714 4.872944238354156 3.222545966088935 TG 16:0_18:1_26:1 4.60845089 1.6278651443695875 2.578603842993516 2.304425323052811 4.182864786416208 3.101096243908986 TG 16:0_18:1_27:1 0.3535955924030763 0.10655890308827647 0.16471244848312025 0.16998053718693462 0.3297621587691195 0.22377346281576818 TG 16:0_22:1_26:1 0.3143026735663433 0.09491024 0.1435343579436343 0.15647374669033928 0.3582604562425917 0.2532842956605578 TG 16:0_24:0_24:1 0.062031117899008864 0.023515526 0.022006374266847914 0.023101473 0.048189352 0.034371409 TG 16:0_24:1_26:1 0.12277234499137427 0.039586942 0.0630915 0.079754916 0.14721580701337994 0.10416866453291883 TG 16:0_26:0_26:1 0.026767802 0.009376802 0.010275310711752838 0.007981555 0.016851421630851675 0.011146564 TG 16:0_26:1_28:1 0.021483003346980646 0.006971962 0.008490784 0.010783770248731724 0.016631014554880294 0.014503280857035764 TG 16:1_16:1_17:1 0.077333625 0.014181708 0.037349666937418896 0.018922440806202773 0.061426857 0.043844107 TG 16:1_16:1_18:1 4.496306245641401 1.0334142456895035 2.649568585174544 1.5553510868108034 4.657734087262121 3.1784191661045402 TG 16:1_16:1_18:2 0.1827100501848097 0.033960163 0.082996718 0.042280357632140025 0.14975521662560498 0.10398307649831386 TG 16:1_16:1_20:4 0.014693262070660289 0.003165347 0.002722501 0.002779498 0.009257377 0.005220258 TG 16:1_17:1_18:1 0.5110568715831942 0.11920185318190325 0.25426925955489404 0.18798240570337482 0.711187088 0.4415136312952325 TG 16:1_18:1_16:2 0.037897883 0.009537107 0.016826852905894252 0.007984141 0.022778360822713842 0 TG 16:1_18:1_17:2 0.03261064 0.005298548 0.011084842614586473 0.009275057 0.032259706 0.020355669 TG 16:1_18:1_18:1 19.74389401708647 5.985125744938764 13.996687398820924 9.473453170609028 27.691640451035322 19.135997986212868 TG 16:1_18:1_18:2 1.0767278097624748 0.19542924553977745 0.5624054250073296 0.34306695239024343 1.3679529238980095 0.8247160900087719 TG 16:1_18:1_20:4 0.151752271 0.034207575 0.056172243341787505 0.040267105 0.14699219262273383 0.080055217 TG 16:1_18:1_22:5 0.076728051 0.016398067335394277 0.039400229 0.022777297744370515 0.090997181 0.050727944650768166 TG 16:1_18:1_22:6 0.090956327 0.015437068406923871 0.043424228045793524 0.017390111184547155 0.071393278 0.04383854 TG 16:1_18:1_24:2 0.4317996619343561 0.16601724898044387 0.3120473818400081 0.38648878635635336 0.9258633409650373 0.6504184771634671 TG 16:1_18:1_26:2 0.6293054977222551 0.1915711975643543 0.3222695107432287 0.47383040388058134 1.0949355271459729 0.9043216833857479 TG 16:1_19:1_26:1 0.4047516065278125 0.10292364147089202 0.17998468035742088 0.2519465883307471 0.5255013008952596 0.35585281251522927 TG 16:1_20:1_22:1 3.536906100562188 1.1203130275584114 2.1339942630518274 2.398796231916208 5.324015576 4.089585818458984 TG 16:1_26:1_24:2 0.032146260777628756 0.009868349 0.017910179543353173 0.031423104 0.062127179 0.043670826 TG 17:0_18:0_18:1 0.6816805549053009 0.23025887571229636 0 0.3319971927803418 0 0.4880564531838467 TG 17:0_18:1_20:1 0.8314689391510545 0.28979719786981045 0.5271520533878166 0.5456159708867026 1.3563052670172524 0.884932848 TG 17:0_18:1_22:1 0.491989318 0.13658904550818493 0.20317044174880686 0.24081917305570308 0.4655642105334424 0.29926050075238314 TG 17:0_18:1_24:1 0.617657671 0.1596749906301949 0.2546392390758691 0.28459257792208753 0.4515593865580928 0.2653279254301887 TG 17:1_18:1_18:1 2.6261093527790154 0.5505875662595995 1.5448174302162152 1.0599013680571137 4.135580169214535 2.6906464924107043 TG 17:1_18:1_18:2 0.16055752218994665 0.043700894968618405 0.096995958 0.069972034 0.22661462133229118 0.14235627235354323 TG 17:1_18:1_24:1 0.353962021 0.093644483 0.1817764004198423 0.23057037131697128 0.49693592673493314 0.3274407690695733 TG 17:1_18:1_24:2 0.054081052 0.015466323130445667 0.029361361355422177 0.044339864 0.11508703080337367 0.078624703 TG 17:1_18:1_26:2 0.05152402 0.015080720228261289 0.027666392737790247 0.034139026 0.098729002 0.065825535 TG 18:0_18:1_18:1 17.590970129719672 6.961775946185469 12.840886506903074 9.566248014522559 26.31640740293694 17.250011610314594 TG 18:0_18:1_18:2 0 0.5012466605671042 1.0369255204821564 0.9372186186774787 0 1.671703160755289 TG 18:0_18:1_19:2 0.1809905466214902 0.072497711 0.1988261740140236 0.14439647455716778 0.4364757294367924 0.2596445606716537 TG 18:0_18:1_20:1 5.840520765160352 1.8062401231719105 3.2094095672521035 2.9673025490299785 6.9892975608924806 4.947714227339725 TG 18:0_18:1_22:5 0.49999348768826885 0.1224352496998872 0.23150889779385225 0.21500484096608916 0.7735542170818851 0.421845718 TG 18:0_18:1_22:6 0.075509393 0.015341831523394876 0.037129625 0.018460559350663243 0.088268688 0.03972585 TG 18:0_18:1_26:1 1.9545971385779586 0.6057132786952639 0.9571633484447889 0.9197299874991132 2.306536024758721 1.5628283059018357 TG 18:0_18:1_27:1 0.072385375 0.021709048217998243 0.040090488704305496 0.043489239 0.08442525 0.057397161 TG 18:0_18:2_18:2 0.3113526882426069 0.090943037 0.3070939535406386 0.15845832061119777 0.5269392804107499 0.2886334259524546 TG 18:0_26:0_18:1 0.39728176853787955 0.12515247259058612 0.13230624031239277 0.11802699 0.38048034479074816 0.2120378575322143 TG 18:1_18:1_18:1 17.432125097175838 6.578202910843009 13.73964612934979 11.909532897705986 35.13735029192693 25.062891715453034 TG 18:1_18:1_18:2 3.7865000201434165 0.790934128 1.6234830605929307 1.5703933266614936 6.281943325215983 3.8634888357573627 TG 18:1_18:1_18:3 0.2937223676502931 0.052097381 0.14093945346686926 0.092135636 0.3995554120031938 0.23091985320127728 TG 18:1_18:1_19:1 1.5978413903038728 0.5212449881020336 1.2400359000922148 1.124937373721725 3.3120664970781846 2.2176409335899527 TG 18:1_18:1_19:2 0.2556175911211356 0.058030338 0.13107239639783314 0.12539295242099396 0.4435934748655152 0.280877374 TG 18:1_18:1_19:3 0.032948509 0.008200602 0.019981029 0.016158326151727756 0.05061932 0.036569240706568355 TG 18:1_18:1_20:1 6.121219851198256 2.579935185 5.148966934070144 5.119726119133376 11.831737217133076 8.596793872 TG 18:1_18:1_20:2 0.917372105 0.3109399999706318 0.6727088079910616 0.719678758 1.9762590786955136 1.3752842658135638 TG 18:1_18:1_20:3 1.0990906618743728 0.23030984064859616 0.4858885104240193 0.4152911412162885 1.4650514392807097 0.8473004491953001 TG 18:1_18:1_21:2 0.11720249005995217 0.033754039114932195 0.071986396 0.082909528 0.24026772351577644 0.160128091 TG 18:1_18:1_21:3 0.038170646 0.012118048010202415 0.013803945825823276 0.026296577307942985 0.063931012 0.042598056 TG 18:1_18:1_21:5 0.009802746 0.001650628 0.003704264 0.003117258 0.016372742132765072 0.008855049 TG 18:1_18:1_22:5 0.26132284249477133 0.072748216 0.18040521220897482 0.11517745228701459 0.35334353224917286 0.24974828328781992 TG 18:1_18:1_22:6 0.24055940598447828 0.041028325 0.095593261 0.059303043 0.34028963635115805 0.169526339 TG 18:1_18:1_24:1 3.8728980728559796 1.2549750472111076 2.3281485374748443 2.542073456911641 6.228014360859831 4.360707913808245 TG 18:1_18:1_24:3 0.12989762991147827 0.048282133 0.080929389 0.10800905831536371 0.23331091481025115 0.13605341692873324 TG 18:1_18:1_24:4 0.15491702337180488 0.055787369 0.093855615 0.1121445624537717 0.273096584 0.1671432846309529 TG 18:1_18:1_24:5 0.1518900286498049 0.036610233788993383 0.076491804 0.064796399 0.2028193385677446 0.11560020353818956 TG 18:1_18:1_26:1 2.4423441795407714 0.9034083285965062 1.6189623728925955 1.9260224410558315 4.147267219224048 3.055846381627271 TG 18:1_18:1_26:2 0.4678832807800592 0.14853288553843452 0.28417731195175033 0.37255699154445515 1.100829976523103 0.7724767458895845 TG 18:1_18:1_26:3 0.15456364408196274 0.043353662236130484 0.060481374597447686 0.094879693 0.19371557862479608 0.12989146721251552 TG 18:1_18:1_26:4 0.080975371 0.026977791902463976 0.034778998 0.047044326 0.1017239226787224 0.06441619 TG 18:1_18:1_26:5 0.05301521 0.01666336 0.032621532 0.029451256719936033 0.061535290720325014 0.043756168 TG 18:1_19:1_20:1 0.35060990076254034 0.13032999288743624 0.23810229776738387 0.2861796990495046 0.735750034 0.486158198 TG 18:1_19:1_20:4 0.035274682 0.006643209 0.010661269086762565 0.015759601089486163 0.054139631 0.030814669736483353 TG 18:1_19:1_26:1 0.15612935336595107 0.049754496087380834 0.079346675 0.10406613189630791 0.17924249613769286 0.1381080590035894 TG 18:1_19:1_26:2 0.023752699770384578 0.007613213 0.012468216723803415 0.019543168068419502 0.041949536021002036 0.031146885361045384 TG 18:1_20:1_20:3 0.31707834373902455 0.106617395 0.19550864110391136 0.2270163717492656 0.5405210517786946 0.34910950459818046 TG 18:1_20:1_21:3 0.015614010684157568 0.005565312 0.010745295 0.015120542834131733 0.029120795156367976 0.022714174126659707 TG 18:1_20:1_22:6 0.056163831566876175 0.011146496243997665 0.028208258956799733 0.019268922631276785 0.070655402 0.037244062 TG 18:1_20:1_26:1 0.6115384722015087 0.19526116191047602 0.2793876890698928 0.38595985024108964 0.7188930967740668 0.6528708003753614 TG 18:1_20:1_26:2 0.088154371 0.034364724 0.063988522 0.073180063 0.21336889526628086 0.12058539884169424 TG 18:1_21:1_26:1 0.021056023727980502 0.007291235 0.011609632 0.022105149307231457 0.035061894 0.026490631400704814 TG 18:1_22:1_26:1 0.13119878968522858 0.040671610206042146 0.079643025 0.10893822121777243 0.20485002400520266 0.14652477 TG 18:1_24:1_20:4 0.030106965697004225 0.011335877248840949 0.015588082718770036 0.022335232217401118 0.046084937 0.029245752 TG 18:1_24:1_22:5 0.024155958 0.007711227 0.012790089685142605 0.012468827469476713 0.034619115 0.020805418613350682 TG 18:1_24:1_26:1 0.087846588 0.025628103 0.041459846242826594 0.064856786 0.10730684157771078 0.082485474 TG 18:1_26:1_20:3 0.063518674 0.018528285934703834 0.027619102349100595 0.035620656 0.08087754 0.045785501 TG 18:1_26:1_20:4 0.058414072228134536 0.014363952936798575 0.022346267 0.028578358443908262 0.062414861404531494 0.039057435 TG 18:1_26:1_22:3 0.017450842 0.006001454 0.008738266 0.014752676819532564 0.021914377 0.014407515588341867 TG 18:1_26:1_22:4 0.022635011857015226 0.007450774 0.01075978 0.013145565 0.029984604 0.017313538310853516 TG 18:1_26:1_22:5 0.019214695337917417 0.005845764 0.007361975 0.008486293 0.019032476199772167 0.010808004478180892 TG 18:1_26:1_24:2 0.015479930810781882 0.005176621 0.009733569 0.017581113 0.037113056 0.025738514817878293 TG 18:1_26:1_24:3 0.0042471 0.001885052 0.002961278 0.006054854 0.008646216 0.005389614 TG 18:1_26:1_26:1 0.032811293 0.010332549221073647 0.012821530088894374 0.019260629 0.033272243 0.020931861 TG 18:1_26:1_26:2 0.006615652 0.002129667 0.003378747 0.006670541 0.012164801864060496 0.006765318 TG 18:1_26:1_28:1 0.004600063 0.002136978 0.002553527 0.003453962 0.005719288 0.003324769 TG 20:0_16:1_20:2 0.526958563 0.24338589936365687 0.5273846886124838 0.6013753647762604 1.7268597504984817 1.128886941546372 TG 22:1_22:1_21:2 0.006218219 0.001890137 0.003590019 0.005581517 0.011120655899190795 0.007016807 TG 24:0_18:1_26:1 0.094889116 0.022178989100676692 0.037847452 0.037305422 0.082143622 0.046259370735184546 TG 26:0_18:1_28:1 0.003513419 0.001262677 0.00183318 0.002107994 0.002658856 0.002531741 TG 26:0_26:0_18:1 0.004957896 0.001973722 0.002492529 0.002075914 0.004840015 0.002892425 TG 8:0_12:0_12:0 0.003296857 0.003111269 0.019158773028719364 0.002328618 0.003925674 0.003090976 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Average Rt(min) Average Mz CE 14:0 20.831 614.58777 CE 16:0 21.733 642.61859 CE 16:1 20.849 640.60272 CE 17:0 21.92 656.63428 CE 17:1 21.343 654.61951 CE 18:0 22.281 670.65118 CE 18:1 21.719 668.63513 CE 18:2 21.058 666.61816 CE 18:3 20.041 664.604 CE 19:1 21.953 682.65045 CE 19:2 21.382 680.63397 CE 20:1 22.249 696.6662 CE 20:2 21.783 694.64966 CE 20:3 21.148 692.63477 CE 20:4 20.422 690.61963 CE 20:5 19.383 688.60413 CE 22:2 22.275 722.68152 CE 22:3 21.854 720.66504 CE 22:4 21.29 718.64899 CE 22:5 20.493 716.63422 CE 22:6 19.841 714.61804 CE 24:0 23.236 754.74365 CE 24:1 22.947 752.72754 CE 24:2 22.626 750.71387 CE 24:3 22.32 748.69702 CE 24:4 21.917 746.68036 CE 24:5 21.424 744.66681 CE 24:6 20.774 742.64984 CE 26:0 23.447 782.77533 CE 26:1 23.194 780.7605 CE 26:2 22.928 778.74518 CE 26:3 22.68 776.72827 CE 26:4 22.357 774.71246 CE 26:5 21.992 772.69714 CE 26:6 21.521 770.68066 CE 28:0 23.641 810.80823 CE 28:1 23.408 808.79095 CE 28:2 23.182 806.77692 CE 28:3 22.973 804.76056 CE 28:4 22.707 802.74457 CE 28:5 22.429 800.72894 CE 30:5 22.608 828.758 Cer 17:1;2O/16:0 10.582 524.50494 Cer 17:1;2O/22:0 14.288 608.59888 Cer 18:0;2O/16:0 11.689 540.53534 Cer 18:0;2O/18:0 12.915 568.56586 Cer 18:0;2O/22:0 15.264 624.62878 Cer 18:0;2O/24:1 15.258 650.64514 Cer 18:1;2O/14:0 9.963 510.48834 Cer 18:1;2O/16:0 11.246 538.51892 Cer 18:1;2O/18:0 12.507 566.55096 Cer 18:1;2O/20:0 13.689 594.5824 Cer 18:1;2O/22:0 14.896 622.61469 Cer 18:1;2O/22:1 13.726 620.59894 Cer 18:1;2O/23:0 15.482 636.62897 Cer 18:1;2O/23:1 14.255 634.61292 Cer 18:1;2O/24:0 16.112 650.64526 Cer 18:1;2O/24:1 14.824 648.62988 Cer 18:1;2O/25:0 16.756 664.65936 Cer 18:1;2O/25:1 15.424 662.646 Cer 18:1;2O/26:0 17.383 678.67767 Cer 18:1;2O/26:1 15.901 676.66003 Cer 18:2;2O/16:0 10.121 536.50439 Cer 18:2;2O/18:0 11.444 564.53387 Cer 18:2;2O/24:1 13.834 646.61444 Cer 18:2;2O/26:1 14.99 674.64441 DG 14:0_16:1 11.118 556.49432 DG 14:0_36:4 21.123 830.75983 DG 16:0_16:0 13.435 586.54071 DG 16:0_16:1 12.368 584.52496 DG 16:0_17:1 12.967 598.5401 DG 16:0_18:0 14.593 614.57294 DG 16:0_18:1 13.505 612.55566 DG 16:0_22:1 15.786 668.62012 DG 16:0_22:5 12.425 660.55762 DG 16:0_24:1 17.093 696.6499 DG 16:0_26:0 19.608 726.69672 DG 16:0_26:1 18.196 724.68121 DG 16:0_36:4 21.764 858.79279 DG 16:1_16:1 11.292 582.50671 DG 16:1_18:1 12.504 610.54034 DG 17:0_18:1 13.925 626.57166 DG 17:1_18:1 13.051 624.55597 DG 18:0_18:0 15.805 642.60333 DG 18:0_18:1 14.642 640.58685 DG 18:1_18:1 13.554 638.57275 DG 18:1_18:2 12.685 636.55707 DG 18:1_19:1 14.113 652.5885 DG 18:1_20:1 14.703 666.60413 DG 18:1_20:2 13.801 664.58716 DG 18:1_22:1 15.871 694.63586 DG 18:1_24:1 17.053 722.66711 DG 18:1_26:1 18.288 750.69861 DG 18:1_28:1 19.551 778.72839 DG 26:0_18:1 19.649 752.71271 LPC 16:1 1.841 494.323 LPC 18:0/0:0 3.532 524.37158 LPC 18:1 2.474 522.3551 LPC 20:1/0:0 3.753 550.38672 LPC 24:1/0:0 6.835 606.44952 LPC 26:1/0:0 8.15 634.48083 LPC 28:0 9.314 664.52869 LPE 16:0 2.532 454.2934 LPE 16:1 1.836 452.27774 LPE 18:0 3.677 482.32458 LPE 18:1 11.966 480.30872 LPE 20:4 1.954 502.29272 LPE 22:5 2.031 528.30835 LPE 22:6 10.423 526.29419 LPE 24:0 8.283 566.4184 SM 30:1;2O 7.029 647.51239 SM 32:1;2O 8.304 675.54401 SM 32:2;2O 7.288 673.52875 SM 33:1;2O 8.934 689.55933 SM 34:0;2O 10.044 705.59088 SM 34:1;2O 9.57 703.5749 SM 34:2;2O 8.524 701.5599 SM 36:1;2O 10.897 731.6068 SM 36:2;2O 9.775 729.59009 SM 38:1;2O 12.192 759.63708 SM 38:2;2O 11.094 757.62231 SM 40:0;2O 13.813 789.68573 SM 40:2;2O 12.216 785.65247 SM 41:1;2O 14.029 801.6853 SM 41:2;2O 12.77 799.6701 SM 42:1;2O 14.559 815.7002 SM 42:2;2O 12.693 813.6846 SM 42:3;2O 12.361 811.6697 SM 44:1;2O 15.811 843.73413 SM 44:2;2O 14.496 841.7146 SM 44:3;2O 13.505 839.69989 TG 10:0_12:0_14:0 14.967 656.58289 TG 12:0_12:0_14:0 16.123 684.61389 TG 12:0_14:0_14:0 17.339 712.64624 TG 12:0_14:0_16:0 18.571 740.67609 TG 12:0_14:0_16:1 17.399 738.66144 TG 12:0_14:0_18:1 18.649 766.69238 TG 12:0_14:1_18:1 17.525 764.67816 TG 12:0_15:0_16:0 19.043 754.69238 TG 12:0_16:0_22:5 18.523 842.72473 TG 12:0_16:1_17:1 18.137 778.69165 TG 12:0_16:1_18:1 18.765 792.70959 TG 14:0_14:0_16:0 19.808 768.70886 TG 14:0_14:0_18:1 18.632 794.72345 TG 14:0_15:0_16:0 20.374 782.72278 TG 14:0_15:0_16:1 19.242 780.70758 TG 14:0_16:0_16:0 20.916 796.73914 TG 14:0_16:0_16:1 19.864 794.72382 TG 14:0_16:0_17:0 21.277 810.7561 TG 14:0_16:0_17:1 20.469 808.7392 TG 14:0_16:0_18:0 21.597 824.77124 TG 14:0_16:0_18:1 20.957 822.75336 TG 14:0_16:0_22:6 19.239 868.73993 TG 14:0_16:1_17:1 19.359 806.72321 TG 14:0_16:1_18:1 19.976 820.73932 TG 14:1_16:1_16:1 17.661 790.69354 TG 14:1_16:1_18:1 18.891 818.72369 TG 15:0_16:0_18:1 21.322 836.76965 TG 15:0_16:0_24:0 22.809 922.88202 TG 16:0_16:0_16:1 19.908 822.75 TG 16:0_16:0_17:0 21.822 838.78735 TG 16:0_16:0_18:0 22.075 852.80322 TG 16:0_16:0_18:1 21.614 850.78491 TG 16:0_16:0_20:4 20.803 872.77185 TG 16:0_16:0_22:6 20.424 896.77112 TG 16:0_16:0_24:0 22.944 936.89453 TG 16:0_16:0_24:1 22.699 934.88196 TG 16:0_16:0_25:0 23.036 950.91425 TG 16:0_16:0_26:1 22.927 962.90979 TG 16:0_16:1_16:1 18.746 820.73889 TG 16:0_16:1_17:1 20.532 834.75568 TG 16:0_16:1_18:1 20.993 848.77039 TG 16:0_16:1_20:4 19.757 870.75452 TG 16:0_16:1_22:6 19.127 894.75507 TG 16:0_17:0_18:0 22.212 866.8172 TG 16:0_17:0_18:1 21.85 864.80243 TG 16:0_17:0_24:1 22.812 948.89667 TG 16:0_17:1_18:1 21.356 862.78577 TG 16:0_18:0_18:0 22.417 880.83466 TG 16:0_18:0_18:1 22.077 878.81744 TG 16:0_18:0_20:0 22.709 908.86499 TG 16:0_18:0_20:1 22.42 906.84967 TG 16:0_18:0_24:0 23.137 964.92865 TG 16:0_18:0_26:0 23.313 992.96069 TG 16:0_18:0_26:1 23.126 990.94171 TG 16:0_18:0_28:0 23.453 1020.99432 TG 16:0_18:1_18:1 21.628 876.80249 TG 16:0_18:1_19:1 21.864 890.8186 TG 16:0_18:1_20:4 20.842 898.78577 TG 16:0_18:1_21:5 20.409 910.78577 TG 16:0_18:1_22:5 20.852 924.80164 TG 16:0_18:1_22:6 20.462 922.78534 TG 16:0_18:1_24:1 22.683 960.89563 TG 16:0_18:1_26:1 22.918 988.92761 TG 16:0_18:1_27:1 23.015 1002.94275 TG 16:0_22:1_26:1 23.293 1044.99048 TG 16:0_24:0_24:1 23.456 1047.00671 TG 16:0_24:1_26:1 23.435 1073.02283 TG 16:0_26:0_26:1 23.742 1103.06921 TG 16:0_26:1_28:1 23.737 1129.08618 TG 16:1_16:1_17:1 19.478 832.74103 TG 16:1_16:1_18:1 20.054 846.75525 TG 16:1_16:1_18:2 19.143 844.74109 TG 16:1_16:1_20:4 18.889 868.73999 TG 16:1_17:1_18:1 20.612 860.77148 TG 16:1_18:1_16:2 19.664 844.73901 TG 16:1_18:1_17:2 19.67 858.75507 TG 16:1_18:1_18:1 21.023 874.78448 TG 16:1_18:1_18:2 20.24 872.77051 TG 16:1_18:1_20:4 19.765 896.771 TG 16:1_18:1_22:5 19.838 922.78516 TG 16:1_18:1_22:6 19.34 920.771 TG 16:1_18:1_24:2 22.137 956.86609 TG 16:1_18:1_26:2 22.437 984.89496 TG 16:1_19:1_26:1 22.8 1000.92871 TG 16:1_20:1_22:1 22.414 958.87842 TG 16:1_26:1_24:2 23.094 1068.98901 TG 17:0_18:0_18:1 22.239 892.83392 TG 17:0_18:1_20:1 22.249 918.84851 TG 17:0_18:1_22:1 22.556 946.87958 TG 17:0_18:1_24:1 22.809 974.91315 TG 17:1_18:1_18:1 21.396 888.80164 TG 17:1_18:1_18:2 20.834 886.78522 TG 17:1_18:1_24:1 22.556 972.89758 TG 17:1_18:1_24:2 22.291 970.88171 TG 17:1_18:1_26:2 22.569 998.90967 TG 18:0_18:1_18:1 22.08 904.83313 TG 18:0_18:1_18:2 21.039 902.81232 TG 18:0_18:1_19:2 21.371 916.83234 TG 18:0_18:1_20:1 22.414 932.86334 TG 18:0_18:1_22:5 21.456 952.83484 TG 18:0_18:1_22:6 21.327 950.8092 TG 18:0_18:1_26:1 23.126 1016.95715 TG 18:0_18:1_27:1 23.207 1030.97559 TG 18:0_18:2_18:2 20.229 900.802 TG 18:0_26:0_18:1 23.299 1018.97589 TG 18:1_18:1_18:1 21.645 902.81616 TG 18:1_18:1_18:2 21.143 900.8028 TG 18:1_18:1_18:3 20.413 898.78485 TG 18:1_18:1_19:1 21.887 916.83264 TG 18:1_18:1_19:2 21.492 914.81683 TG 18:1_18:1_19:3 20.887 912.80121 TG 18:1_18:1_20:1 22.08 930.84717 TG 18:1_18:1_20:2 21.762 928.83453 TG 18:1_18:1_20:3 21.332 926.8161 TG 18:1_18:1_21:2 21.954 942.84833 TG 18:1_18:1_21:3 21.556 940.83185 TG 18:1_18:1_21:5 20.415 936.80084 TG 18:1_18:1_22:5 20.866 950.81763 TG 18:1_18:1_22:6 20.49 948.80164 TG 18:1_18:1_24:1 22.682 986.90979 TG 18:1_18:1_24:3 22.205 982.88269 TG 18:1_18:1_24:4 21.891 980.8631 TG 18:1_18:1_24:5 21.474 978.85004 TG 18:1_18:1_26:1 22.901 1014.94189 TG 18:1_18:1_26:2 22.696 1012.92651 TG 18:1_18:1_26:3 22.48 1010.9137 TG 18:1_18:1_26:4 22.249 1008.8985 TG 18:1_18:1_26:5 21.931 1006.87921 TG 18:1_19:1_20:1 22.264 944.86523 TG 18:1_19:1_20:4 21.17 938.81732 TG 18:1_19:1_26:1 23.006 1028.95801 TG 18:1_19:1_26:2 22.811 1026.94543 TG 18:1_20:1_20:3 21.847 954.8479 TG 18:1_20:1_21:3 21.998 968.86664 TG 18:1_20:1_22:6 21.308 976.83545 TG 18:1_20:1_26:1 23.099 1042.97217 TG 18:1_20:1_26:2 22.916 1040.95996 TG 18:1_21:1_26:1 23.18 1056.98877 TG 18:1_22:1_26:1 23.261 1071.00757 TG 18:1_24:1_20:4 22.235 1008.90448 TG 18:1_24:1_22:5 22.318 1034.91418 TG 18:1_24:1_26:1 23.406 1099.03845 TG 18:1_26:1_20:3 22.749 1038.94324 TG 18:1_26:1_20:4 22.59 1036.92847 TG 18:1_26:1_22:3 22.959 1066.97437 TG 18:1_26:1_22:4 22.825 1064.95679 TG 18:1_26:1_22:5 22.582 1062.94531 TG 18:1_26:1_24:2 23.264 1097.02295 TG 18:1_26:1_24:3 23.14 1095.00818 TG 18:1_26:1_26:1 23.51 1127.06775 TG 18:1_26:1_26:2 23.411 1125.05396 TG 18:1_26:1_28:1 23.697 1155.10107 TG 20:0_16:1_20:2 21.653 930.8468 TG 22:1_22:1_21:2 23.015 1054.97607 TG 24:0_18:1_26:1 23.581 1101.05554 TG 26:0_18:1_28:1 23.863 1157.11584 TG 26:0_26:0_18:1 23.873 1131.09998 TG 8:0_12:0_12:0 12.696 600.52075 METABOLITES_END #END