#METABOLOMICS WORKBENCH Rene_Neuhaus_20250314_071413 DATATRACK_ID:5721 STUDY_ID:ST003807 ANALYSIS_ID:AN006259 PROJECT_ID:PR002381 VERSION 1 CREATED_ON March 17, 2025, 2:13 am #PROJECT PR:PROJECT_TITLE A lipidomic exploration of the effects of high-intensity interval exercise in PR:PROJECT_TITLE healthy men after metformin intake PR:PROJECT_TYPE Lipidomics untargeted MS PR:PROJECT_SUMMARY Changes in the plasma levels of individual lipids could play an important role PR:PROJECT_SUMMARY in the response to exercise under metformin intake. This study explores the PR:PROJECT_SUMMARY changes in the plasma lipidome of nine healthy individuals for 12 h after PR:PROJECT_SUMMARY metformin intake followed by either high-intensity interval exercise (HIIE) or PR:PROJECT_SUMMARY rest, followed by food intake in both cases. We observed several variations in PR:PROJECT_SUMMARY the lipid profiles due to HIIE. Most affected lipid classes are fatty acids, PR:PROJECT_SUMMARY acyl carnitines, phosphatidylcholines, sphingomyelins, and triglycerides, of PR:PROJECT_SUMMARY which most were increased upon HIIE, but only some (mainly fatty acids and PR:PROJECT_SUMMARY triglycerides) upon food intake. PR:INSTITUTE University CEU San Pablo PR:DEPARTMENT Chemistry and Biochemistry PR:LABORATORY CEMBIO PR:LAST_NAME Neuhaus PR:FIRST_NAME René PR:ADDRESS Urb. Montepríncipe, Alcorcón, Madrid, 28925, Spain PR:EMAIL rene.neuhaus@ceu.es PR:PHONE +34611042778 #STUDY ST:STUDY_TITLE A lipidomic exploration of the effects of high-intensity interval exercise in ST:STUDY_TITLE healthy men after metformin intake ST:STUDY_SUMMARY Changes in the plasma levels of individual lipids could play an important role ST:STUDY_SUMMARY in the response to exercise under metformin intake. This study explores the ST:STUDY_SUMMARY changes in the plasma lipidome of nine healthy individuals for 12 h after ST:STUDY_SUMMARY metformin intake followed by either high-intensity interval exercise (HIIE) or ST:STUDY_SUMMARY rest, followed by food intake in both cases. We observed several variations in ST:STUDY_SUMMARY the lipid profiles due to HIIE. Most affected lipid classes are fatty acids, ST:STUDY_SUMMARY acyl carnitines, phosphatidylcholines, sphingomyelins, and triglycerides, of ST:STUDY_SUMMARY which most were increased upon HIIE, but only some (mainly fatty acids and ST:STUDY_SUMMARY triglycerides) upon food intake. ST:INSTITUTE University CEU San Pablo ST:DEPARTMENT Chemistry and Biochemistry ST:LABORATORY CEMBIO ST:LAST_NAME Neuhaus ST:FIRST_NAME René ST:ADDRESS Urb. 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RAW_FILE_NAME=A6_12_N.mzML SUBJECT_SAMPLE_FACTORS P_7 A7_12 Sample source:Plasma | Session:Exercise | Timepoint:12 RAW_FILE_NAME=A7_12_P.mzML; RAW_FILE_NAME=A7_12_N.mzML SUBJECT_SAMPLE_FACTORS P_8 A8_12 Sample source:Plasma | Session:Exercise | Timepoint:12 RAW_FILE_NAME=A8_12_P.mzML; RAW_FILE_NAME=A8_12_N.mzML SUBJECT_SAMPLE_FACTORS P_9 A9_12 Sample source:Plasma | Session:Exercise | Timepoint:12 RAW_FILE_NAME=A9_12_P.mzML; RAW_FILE_NAME=A9_12_N.mzML SUBJECT_SAMPLE_FACTORS P_1 A1_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A1_13_P.mzML; RAW_FILE_NAME=A1_13_N.mzML SUBJECT_SAMPLE_FACTORS P_2 A2_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A2_13_P.mzML; RAW_FILE_NAME=A2_13_N.mzML SUBJECT_SAMPLE_FACTORS P_3 A3_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A3_13_P.mzML; RAW_FILE_NAME=A3_13_N.mzML SUBJECT_SAMPLE_FACTORS P_4 A4_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A4_13_P.mzML; RAW_FILE_NAME=A4_13_N.mzML SUBJECT_SAMPLE_FACTORS P_5 A5_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A5_13_P.mzML; RAW_FILE_NAME=A5_13_N.mzML SUBJECT_SAMPLE_FACTORS P_6 A6_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A6_13_P.mzML; RAW_FILE_NAME=A6_13_N.mzML SUBJECT_SAMPLE_FACTORS P_7 A7_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A7_13_P.mzML; RAW_FILE_NAME=A7_13_N.mzML SUBJECT_SAMPLE_FACTORS P_8 A8_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A8_13_P.mzML; RAW_FILE_NAME=A8_13_N.mzML SUBJECT_SAMPLE_FACTORS P_9 A9_13 Sample source:Plasma | Session:Exercise | Timepoint:13 RAW_FILE_NAME=A9_13_P.mzML; RAW_FILE_NAME=A9_13_N.mzML SUBJECT_SAMPLE_FACTORS P_1 C1_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C1_0_P.mzML; RAW_FILE_NAME=C1_0_N.mzML SUBJECT_SAMPLE_FACTORS P_2 C2_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C2_0_P.mzML; RAW_FILE_NAME=C2_0_N.mzML SUBJECT_SAMPLE_FACTORS P_3 C3_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C3_0_P.mzML; RAW_FILE_NAME=C3_0_N.mzML SUBJECT_SAMPLE_FACTORS P_4 C4_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C4_0_P.mzML; RAW_FILE_NAME=C4_0_N.mzML SUBJECT_SAMPLE_FACTORS P_5 C5_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C5_0_P.mzML; RAW_FILE_NAME=C5_0_N.mzML SUBJECT_SAMPLE_FACTORS P_6 C6_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C6_0_P.mzML; RAW_FILE_NAME=C6_0_N.mzML SUBJECT_SAMPLE_FACTORS P_7 C7_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C7_0_P.mzML; RAW_FILE_NAME=C7_0_N.mzML SUBJECT_SAMPLE_FACTORS P_8 C8_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C8_0_P.mzML; RAW_FILE_NAME=C8_0_N.mzML SUBJECT_SAMPLE_FACTORS P_9 C9_0 Sample source:Plasma | Session:Resting | Timepoint:0 RAW_FILE_NAME=C9_0_P.mzML; RAW_FILE_NAME=C9_0_N.mzML SUBJECT_SAMPLE_FACTORS P_1 C1_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C1_1_P.mzML; RAW_FILE_NAME=C1_1_N.mzML SUBJECT_SAMPLE_FACTORS P_2 C2_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C2_1_P.mzML; RAW_FILE_NAME=C2_1_N.mzML SUBJECT_SAMPLE_FACTORS P_3 C3_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C3_1_P.mzML; RAW_FILE_NAME=C3_1_N.mzML SUBJECT_SAMPLE_FACTORS P_4 C4_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C4_1_P.mzML; RAW_FILE_NAME=C4_1_N.mzML SUBJECT_SAMPLE_FACTORS P_5 C5_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C5_1_P.mzML; RAW_FILE_NAME=C5_1_N.mzML SUBJECT_SAMPLE_FACTORS P_6 C6_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C6_1_P.mzML; RAW_FILE_NAME=C6_1_N.mzML SUBJECT_SAMPLE_FACTORS P_7 C7_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C7_1_P.mzML; RAW_FILE_NAME=C7_1_N.mzML SUBJECT_SAMPLE_FACTORS P_8 C8_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C8_1_P.mzML; RAW_FILE_NAME=C8_1_N.mzML SUBJECT_SAMPLE_FACTORS P_9 C9_1 Sample source:Plasma | Session:Resting | Timepoint:1 RAW_FILE_NAME=C9_1_P.mzML; RAW_FILE_NAME=C9_1_N.mzML SUBJECT_SAMPLE_FACTORS P_1 C1_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C1_2_P.mzML; RAW_FILE_NAME=C1_2_N.mzML SUBJECT_SAMPLE_FACTORS P_2 C2_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C2_2_P.mzML; RAW_FILE_NAME=C2_2_N.mzML SUBJECT_SAMPLE_FACTORS P_3 C3_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C3_2_P.mzML; RAW_FILE_NAME=C3_2_N.mzML SUBJECT_SAMPLE_FACTORS P_4 C4_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C4_2_P.mzML; RAW_FILE_NAME=C4_2_N.mzML SUBJECT_SAMPLE_FACTORS P_5 C5_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C5_2_P.mzML; RAW_FILE_NAME=C5_2_N.mzML SUBJECT_SAMPLE_FACTORS P_6 C6_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C6_2_P.mzML; RAW_FILE_NAME=C6_2_N.mzML SUBJECT_SAMPLE_FACTORS P_7 C7_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C7_2_P.mzML; RAW_FILE_NAME=C7_2_N.mzML SUBJECT_SAMPLE_FACTORS P_8 C8_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C8_2_P.mzML; RAW_FILE_NAME=C8_2_N.mzML SUBJECT_SAMPLE_FACTORS P_9 C9_2 Sample source:Plasma | Session:Resting | Timepoint:2 RAW_FILE_NAME=C9_2_P.mzML; RAW_FILE_NAME=C9_2_N.mzML SUBJECT_SAMPLE_FACTORS P_1 C1_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C1_3_P.mzML; RAW_FILE_NAME=C1_3_N.mzML SUBJECT_SAMPLE_FACTORS P_2 C2_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C2_3_P.mzML; RAW_FILE_NAME=C2_3_N.mzML SUBJECT_SAMPLE_FACTORS P_3 C3_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C3_3_P.mzML; RAW_FILE_NAME=C3_3_N.mzML SUBJECT_SAMPLE_FACTORS P_4 C4_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C4_3_P.mzML; RAW_FILE_NAME=C4_3_N.mzML SUBJECT_SAMPLE_FACTORS P_5 C5_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C5_3_P.mzML; RAW_FILE_NAME=C5_3_N.mzML SUBJECT_SAMPLE_FACTORS P_6 C6_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C6_3_P.mzML; RAW_FILE_NAME=C6_3_N.mzML SUBJECT_SAMPLE_FACTORS P_7 C7_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C7_3_P.mzML; RAW_FILE_NAME=C7_3_N.mzML SUBJECT_SAMPLE_FACTORS P_8 C8_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C8_3_P.mzML; RAW_FILE_NAME=C8_3_N.mzML SUBJECT_SAMPLE_FACTORS P_9 C9_3 Sample source:Plasma | Session:Resting | Timepoint:3 RAW_FILE_NAME=C9_3_P.mzML; RAW_FILE_NAME=C9_3_N.mzML SUBJECT_SAMPLE_FACTORS P_1 C1_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C1_4_P.mzML; RAW_FILE_NAME=C1_4_N.mzML SUBJECT_SAMPLE_FACTORS P_2 C2_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C2_4_P.mzML; RAW_FILE_NAME=C2_4_N.mzML SUBJECT_SAMPLE_FACTORS P_3 C3_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C3_4_P.mzML; RAW_FILE_NAME=C3_4_N.mzML SUBJECT_SAMPLE_FACTORS P_4 C4_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C4_4_P.mzML; RAW_FILE_NAME=C4_4_N.mzML SUBJECT_SAMPLE_FACTORS P_5 C5_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C5_4_P.mzML; RAW_FILE_NAME=C5_4_N.mzML SUBJECT_SAMPLE_FACTORS P_6 C6_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C6_4_P.mzML; RAW_FILE_NAME=C6_4_N.mzML SUBJECT_SAMPLE_FACTORS P_7 C7_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C7_4_P.mzML; RAW_FILE_NAME=C7_4_N.mzML SUBJECT_SAMPLE_FACTORS P_8 C8_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C8_4_P.mzML; RAW_FILE_NAME=C8_4_N.mzML SUBJECT_SAMPLE_FACTORS P_9 C9_4 Sample source:Plasma | Session:Resting | Timepoint:5 RAW_FILE_NAME=C9_4_P.mzML; RAW_FILE_NAME=C9_4_N.mzML SUBJECT_SAMPLE_FACTORS P_1 C1_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C1_5_P.mzML; RAW_FILE_NAME=C1_5_N.mzML SUBJECT_SAMPLE_FACTORS P_2 C2_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C2_5_P.mzML; RAW_FILE_NAME=C2_5_N.mzML SUBJECT_SAMPLE_FACTORS P_3 C3_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C3_5_P.mzML; RAW_FILE_NAME=C3_5_N.mzML SUBJECT_SAMPLE_FACTORS P_4 C4_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C4_5_P.mzML; RAW_FILE_NAME=C4_5_N.mzML SUBJECT_SAMPLE_FACTORS P_5 C5_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C5_5_P.mzML; RAW_FILE_NAME=C5_5_N.mzML SUBJECT_SAMPLE_FACTORS P_6 C6_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C6_5_P.mzML; RAW_FILE_NAME=C6_5_N.mzML SUBJECT_SAMPLE_FACTORS P_7 C7_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C7_5_P.mzML; RAW_FILE_NAME=C7_5_N.mzML SUBJECT_SAMPLE_FACTORS P_8 C8_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C8_5_P.mzML; RAW_FILE_NAME=C8_5_N.mzML SUBJECT_SAMPLE_FACTORS P_9 C9_5 Sample source:Plasma | Session:Resting | Timepoint:9 RAW_FILE_NAME=C9_5_P.mzML; RAW_FILE_NAME=C9_5_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_1 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_1_P.mzML; RAW_FILE_NAME=QC_1_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_2 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_2_P.mzML; RAW_FILE_NAME=QC_2_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_3 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_3_P.mzML; RAW_FILE_NAME=QC_3_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_4 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_4_P.mzML; RAW_FILE_NAME=QC_4_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_5 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_5_P.mzML; RAW_FILE_NAME=QC_5_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_6 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_6_P.mzML; RAW_FILE_NAME=QC_6_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_7 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_7_P.mzML; RAW_FILE_NAME=QC_7_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_8 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_8_P.mzML; RAW_FILE_NAME=QC_8_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_9 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_9_P.mzML; RAW_FILE_NAME=QC_9_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_10 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_10_P.mzML; RAW_FILE_NAME=QC_10_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_11 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_11_P.mzML; RAW_FILE_NAME=QC_11_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_12 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_12_P.mzML; RAW_FILE_NAME=QC_12_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_13 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_13_P.mzML; RAW_FILE_NAME=QC_13_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_14 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_14_P.mzML; RAW_FILE_NAME=QC_14_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_15 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_15_P.mzML; RAW_FILE_NAME=QC_15_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_16 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_16_P.mzML; RAW_FILE_NAME=QC_16_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_17 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_17_P.mzML; RAW_FILE_NAME=QC_17_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_18 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_18_P.mzML; RAW_FILE_NAME=QC_18_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_19 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_19_P.mzML; RAW_FILE_NAME=QC_19_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_20 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_20_P.mzML; RAW_FILE_NAME=QC_20_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_21 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_21_P.mzML; RAW_FILE_NAME=QC_21_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_22 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_22_P.mzML; RAW_FILE_NAME=QC_22_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_23 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_23_P.mzML; RAW_FILE_NAME=QC_23_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_24 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_24_P.mzML; RAW_FILE_NAME=QC_24_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_25 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_25_P.mzML; RAW_FILE_NAME=QC_25_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_26 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_26_P.mzML; RAW_FILE_NAME=QC_26_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_27 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_27_P.mzML; RAW_FILE_NAME=QC_27_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_28 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_28_P.mzML; RAW_FILE_NAME=QC_28_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_29 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_29_P.mzML; RAW_FILE_NAME=QC_29_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_30 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_30_P.mzML; RAW_FILE_NAME=QC_30_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_31 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_31_P.mzML; RAW_FILE_NAME=QC_31_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_32 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_32_P.mzML; RAW_FILE_NAME=QC_32_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_33 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_33_P.mzML; RAW_FILE_NAME=QC_33_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_34 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_34_P.mzML; RAW_FILE_NAME=QC_34_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_35 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_35_P.mzML; RAW_FILE_NAME=QC_35_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_36 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_36_P.mzML; RAW_FILE_NAME=QC_36_N.mzML SUBJECT_SAMPLE_FACTORS QC QC_37 Sample source:Plasma | Session:QC | Timepoint:QC RAW_FILE_NAME=QC_37_P.mzML; RAW_FILE_NAME=QC_37_N.mzML #COLLECTION CO:COLLECTION_SUMMARY Venous blood samples were collected in EDTA tubes, in the exercise session (A) CO:COLLECTION_SUMMARY before taking metformin (0 h, T0) and after taking metformin at 40 min (T1, CO:COLLECTION_SUMMARY before exercise), 1 h 25 min (T2, 40 min after start of exercise), 2 h 5 min CO:COLLECTION_SUMMARY (T3, 4 min after finishing exercise), 2 h 30 min (T4), 3 h (T5), 3 h 30 min CO:COLLECTION_SUMMARY (T6), 4 h (T7, after banana intake), 4 h 30 min (T8), 6 h (T9), 7 h (T10, after CO:COLLECTION_SUMMARY meal intake), 8 h (T11), 10 h (T12) and 12 h (T13). In the resting session (C), CO:COLLECTION_SUMMARY blood was taken before taking metformin (0 h, T0) and after taking metformin at CO:COLLECTION_SUMMARY 40 min (T1), 1 h 25 min (T2), 2 h 5 min (T3), 3 h (T5) and 6 h (T9). CO:SAMPLE_TYPE Blood (plasma) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Plasma was collected by centrifugation and stored at –80 ºC #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Plasma samples were thawed on ice for approximately 1 h and vortex-mixed for 2 SP:SAMPLEPREP_SUMMARY min. Then, 50 μL of each sample were transferred to an Eppendorf vial on ice. SP:SAMPLEPREP_SUMMARY Subsequently, 175 μL of ice-cold methanol (stored at –20 °C), containing 2.3 SP:SAMPLEPREP_SUMMARY ppm of sphinganine (d17:0) and 4.6 ppm of palmitic acid-d31. After shaking the SP:SAMPLEPREP_SUMMARY sample for 1 min, 175 μL of MTBE and 10 μL of LightSPLASH LIPIDOMIX SP:SAMPLEPREP_SUMMARY Quantitative Mass Spec Primary Standard mix were added. Samples were SP:SAMPLEPREP_SUMMARY vortex-mixed for 30 min and centrifuged for 15 min at 15 °C and 16,100 x g. SP:SAMPLEPREP_SUMMARY Finally, 100 μL of supernatants were added to chromatography vials, centrifuged SP:SAMPLEPREP_SUMMARY for 5 min at 15 °C and 2,000 x g, and then injected into the LC-MS system. SP:SAMPLEPREP_SUMMARY Extraction solvents were used as a blank and followed the same procedure as the SP:SAMPLEPREP_SUMMARY samples. Quality control (QC) samples were prepared by pooling equal volumes of SP:SAMPLEPREP_SUMMARY all samples. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Samples were analyzed using an Agilent 1290 Infinity II UHPLC system coupled to CH:CHROMATOGRAPHY_SUMMARY an Agilent 6545 quadrupole time-of-flight (QTOF) mass spectrometer (Agilent, CH:CHROMATOGRAPHY_SUMMARY Santa Clara, CA, USA). An Agilent InfinityLab Poroshell 120 EC-C18 (3.0 × 100 CH:CHROMATOGRAPHY_SUMMARY mm, 2.7 µm) column, protected by a compatible guard column (Agilent InfinityLab CH:CHROMATOGRAPHY_SUMMARY Poroshell 120 EC-C18, 3.0 × 5 mm, 2.7 µm), was employed for the analysis. The CH:CHROMATOGRAPHY_SUMMARY column temperature was set at 50oC, while the autosampler’s temperature was CH:CHROMATOGRAPHY_SUMMARY set at 15 °C. Data were acquired in both ionization modes in separate runs. For CH:CHROMATOGRAPHY_SUMMARY positive ionization (ESI+), the injection volume was set at 0.5 μL, while, for CH:CHROMATOGRAPHY_SUMMARY negative ionization (ESI-), at 1 μL. Elution was performed with a solvent CH:CHROMATOGRAPHY_SUMMARY system consisting of (A) 10 mM ammonium acetate, 0.2 mM ammonium fluoride in CH:CHROMATOGRAPHY_SUMMARY water/methanol (9:1, v/v) and (B) 10 mM ammonium acetate, 0.2 mM ammonium CH:CHROMATOGRAPHY_SUMMARY fluoride in acetonitrile/methanol/isopropanol (2:3:5, v/v/v). The elution CH:CHROMATOGRAPHY_SUMMARY program applied was 70% B at 0–1 min, linear gradient to 86% B until 3.5 min, CH:CHROMATOGRAPHY_SUMMARY held until 10 min, linear gradient to 100% B until 11 min, and held until 17 CH:CHROMATOGRAPHY_SUMMARY min. Then, the system returned to the initial condition for a total of 2 min. CH:CHROMATOGRAPHY_SUMMARY The total analysis time was 19 min. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity II CH:COLUMN_NAME Agilent InfinityLab Poroshell 120 EC-C18 (100 x 3mm,2.7um) CH:SOLVENT_A 10 mM ammonium acetate, 0.2 mM ammonium fluoride in 9:1 water/methanol CH:SOLVENT_B 10 mM ammonium acetate, 0.2 mM ammonium fluoride in 2:3:5 CH:SOLVENT_B acetonitrile/methanol/isopropanol CH:FLOW_GRADIENT 0-1 min: 70% B; 1-3.5 min: linear increase until 86% B; 3.5-10 min: 86% B; 10-11 CH:FLOW_GRADIENT min: linear increase until 100% B; 11-17 min: 100% B. Then the equipment CH:FLOW_GRADIENT returned to the initial conditions in 0.1 min, which were held for 1.9 min for CH:FLOW_GRADIENT column reconditioning. CH:FLOW_RATE 0.6 mL/min CH:COLUMN_TEMPERATURE 50 ºC #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Agilent 6545 QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS The QTOF mass spectrometer, equipped with a dual atmospheric jet stream MS:MS_COMMENTS electrospray ionization (ESI) ion source, was configured with the following MS:MS_COMMENTS parameters: 150 V fragmentor, 65 V skimmer, 3500 V capillary voltage, 750 V MS:MS_COMMENTS octopole radio frequency voltage, 10 L/min nebulizer gas flow, 200 °C gas MS:MS_COMMENTS temperature, 50 psi nebulizer gas pressure, 12 L/min sheath gas flow, and 300 MS:MS_COMMENTS °C sheath gas temperature. In full scan mode, operated from 50 to 1.800 m/z MS:MS_COMMENTS with a scan rate of 3 spectra/s, data were collected for both ionization modes. MS:MS_COMMENTS A solution of two reference mass compounds was used throughout the analysis: MS:MS_COMMENTS purine (C5H4N4) at m/z 121.0509 and HP-0921 (C18H18O6N3P3F24) at m/z 922.0098. MS:MS_COMMENTS These masses were continuously infused into the system to provide constant mass MS:MS_COMMENTS correction. MS:MS_RESULTS_FILE ST003807_AN006259_Results.txt UNITS:Peak area Has m/z:Neutral masses Has RT:Yes RT units:Minutes #END