Summary of Study ST000706
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000503. The data can be accessed directly via it's Project DOI: 10.21228/M8ND66 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000706 |
Study Title | Effect of DASH Diet on Gut Microbiome (SCFA from stool) |
Study Type | MS analysis |
Study Summary | This research will examine the effect of the currently recommended DASH diet versus a Vegetarian DASH diet on the gut microbiome and risk for cardiovascular disease in pre-hypertensive obese African American women. We will define the gut microbiota profile, short chain fatty acid production, breath hydrogen/methane response, plasma lipopolysaccharide production and other biomarkers of inflammation in response to diet type in obese African American pre-hypertensive females at baseline and following placement on the traditional DASH plan or DASH Vegetarian diet. We will also define these parameters in African American women adhering to a Vegetarian or Vegan Diet. Our goal is to determine how the gut microbiome modulates host physiology and immune function in response to diet type. By evaluating the effect of a recommended DASH dietary pattern versus a Vegetarian DASH plan on the gut microbiome and its fermentation products, we aim to identify novel information about how these diet types strategically reduce cardiovascular disease risk through gut:microbiota:host interaction. |
Institute | University of Michigan |
Department | Biomedical Research Core Facilities |
Laboratory | Metabolomics core |
Last Name | Kachman |
First Name | Maureen |
Address | 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 |
mkachman@med.umich.edu | |
Phone | (734) 232-8175 |
Submit Date | 2017-06-19 |
Num Groups | 5 |
Total Subjects | 13 |
Study Comments | We will define the gut microbiota profile, short chain fatty acid production, breath hydrogen/methane response, plasma lipopolysaccharide production and other biomarkers of inflammation in response to diet type in obese African American pre-hypertensive females at baseline and following placement on the traditional DASH plan or DASH Vegetarian diet. We will also define these parameters in African American women adhering to a Vegetarian or Vegan Diet. Our goal is to determine how the gut microbiome modulates host physiology and immune function in response to diet type. By evaluating the effect of a recommended DASH dietary pattern versus a Vegetarian DASH plan on the gut microbiome and its fermentation products, we aim to identify novel information about how these diet types strategically reduce cardiovascular disease risk through gut:microbiota:host interaction. |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | GC-MS |
Release Date | 2017-12-06 |
Release Version | 1 |
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Collection:
Collection ID: | CO000723 |
Collection Summary: | - |
Sample Type: | Feces |