Metabolomics Workbench Archive

Metabolomics Workbench Highlights

February, 2017

Pilot and Feasibility Projects

The six Regional Comprehensive Metabolomics Research Cores (RCMRCs) are accepting applications for exploratory biomedical research projects utilizing metabolomics technology. These "Pilot and Feasibility (P&F) studies" are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research. The awards are intended to support projects that will provide preliminary data for new extramural proposal submission. Application deadline: March 16, 2017. See our Funding Opportunities page for more information.

October, 2016

Human Metabolome Gene/Protein Database (MGP) - The Human Metabolome Gene/Protein Database (MGP) of metabolome-related genes and proteins contains data for over 7300 genes and over 15,500 proteins. Each record is enhanced with Gene Ontology (GO) annotations, REACTOME pathway annotations, InterPro domain annotations, UniProt annotations, and a listing of related proteins. MGP can be searched by any of MGP_ID, Entrez Gene_ID, Gene Name, Gene Symbol, Synonyms, Alternate names, HMDB Pathway, and Reactome Pathway.

April, 2016

Bubble-Plot searches

sample source species disease pathways metabolite class

January, 2016

Studies deposited

Over 200 studies have been deposited and are listed on the Metabolomics Workbench Study Summary page. For the over 100 studies that have been released to the public, you can view metadata, download experimental results, and perform various online analyses.

Online data submission

A new online data submission system is now available. See our Upload and Manage Experimental Data and Metadata page for complete requirements for depositing data via the Metabolomics Workbench, including a link to the new interface.

July, 2015

Order Standards Now! As part of the NIH Common Fund's Metabolomics Program, the Metabolite Standards Synthesis Cores (MSSC) aim to provide metabolomics researchers with high quality, freely available metabolite standards. Several of these compounds have been synthesized and are now available for shipment.

Jan, 2015

Metabolomics Workbench REST Service

The REST service enables access to a variety of data (including metabolite structures, study metadata and experimental results). These requests may be carried out using a web browser or may be embedded in 3rd party applications or scripts to enable rapid programmatic access.

Aug, 2014

Funded P&F Projects 2014 (as of May 2014)

A number of Pilot and Feasibility studies (P&F) -- exploratory biomedical research projects utilizing metabolomics technology -- have recently been funded via our six Regional Comprehensive Metabolomics Research Cores (RCMRCs). These P&F awards are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research, and to support projects that will provide preliminary data for new extramural proposal submission.

see the list of funded projects

April, 2014

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

In this project from the Mayo clinic, researchers examined global metabolic changes in both plasma and cerebrospinal fluid (CSF) from individuals representing the spectrum of Alzheimer’s Disease - ranging from cognitively normal (CN) to mild cognitive impairment (MCI) to Alzheimer’s Disease (AD). Data produced from their non-targeted metabolomics approach, point to alterations in a number of metabolic pathways, and pave the way for identification of novel therapeutic targets.

Reference: Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One. 2013 May 20;8(5):e63644.
doi: 10.1371/journal.pone.0063644

October, 2013

Three new RCMRCs have joined the NIH Metabolomics Consortium

May, 2013

About the Metabolomics Workbench

The Metabolomics Workbench is a scalable and extensible informatics infrastructure which will serve as a national metabolomics resource. This is a companion to RCMRCs and is a part of the Common Fund Initiative in metabolomics. The Metabolomics Workbench will coordinate data activities of national and international metabolomics centers and initiatives, serve as a national data repository and develop a Workbench that will have data, query and analysis interfaces, and tools for interactive analysis and integration of metabolomics data.

February, 2013

Regional Comprehensive Metabolomics Research Cores (RCMRC) accepting applications for Pilot and Feasibility Studies

The three Regional Comprehensive Metabolomics Research Cores (RCMRC) are accepting applications for exploratory biomedical research projects utilizing metabolomics technology. These "Pilot and Feasibility" Studies (P/F) are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research.

These awards are intended to support projects that will provide preliminary data for new extramural proposal submission. The application deadline is March 1, 2013 and earliest funding start date May 1, 2013.

News Archive

09-07-2017 - Slides from August 28th NIH Common Fund Pre-application webinar - The August 28th NIH Common Fund Metabolomics Program Pre-application webinar was aimed at providing information related to recent FOAs for Stage II of the NIH Common Fund Metabolomics Program.

08-15-2017 - Funding Opportunity: RFA-RM-17-015: Metabolomics Core for the Undiagnosed Diseases Network (UDN) Phase II (U01)

The NIH Common Fund’s Undiagnosed Diseases Network (UDN) is a research study with three overarching goals: 1) improve the level of diagnosis and care for patients with undiagnosed diseases 2) to facilitate research into the etiology of undiagnosed diseases and 3) to promote an integrated and collaborative community of laboratory and clinical investigators prepared to investigate these difficult to diagnose diseases. The NIH is now inviting applications for Phase II of the UDN. One component of the network will be filled via RFA-RM-17-015: Metabolomics Core for the Undiagnosed Diseases Network (UDN) Phase II (U01). The purpose of this funding opportunity is to provide the Metabolomics Core for participants seen through the UDN. The Metabolomics Core will provide clinical expertise and consultation to the UDN network. It will also provide specific expertise in at least two of the following areas: glycans, lipids, and mitochondria. Additionally, the core will serve as a network conduit that will provide access to resources and world class investigators with expertise in metabolomics beyond the scope of the cores’ own expertise.

08-02-2017 - Four new funding opportunities for Stage II of the NIH Common Fund Metabolomics Program have just been published in the NIH Guide for Grants and Contracts:

05-27-2017 - Upcoming FOAs - Funding Opportunities for Stage II of the NIH Common Fund Metabolomics Program to be published soon

05-10-2017 - 2017 National Institutes of Health (NIH) Metabolomics Consortium Annual Investigators Program Review Meeting
September 27-28, 2017
Davis, CA, USA
(invitation-only - NIH Common Fund Metabolomics Consortium)

04-27-2017 - 2017 UAB Metabolomics Workshop
July 16-21, 2017
Birmingham, AL, USA

The 2017 UAB Metabolomics Workshop will be held July 16-21 in Birmingham, Alabama. There will be slots for 40 attendees. UAB particularly encourages graduate students and postdoctoral and clinical fellows. Those at US universities and institutes may qualify for support from NIH funding. UAB also encourages applications from all levels of faculty and other research personnel as well as all genders and ethnicities.

01-13-2017 - Announcement: 2017 International Summer Sessions in Metabolomics
August 14-25, 2017
UC Davis, CA Alumni Center, Davis, CA, USA

This course will feature hands-on training with real-world metabolomics data covering LC/MS compound identification, data processing, statistical analysis, network mapping and data interpretation. Instruction will include a variety of software, workflows, and algorithms but also give theoretical background information and overviews.

01-18-2017 - 2017 Call for Pilot and Feasibility Project Applications - The six Regional Comprehensive Metabolomics Research Cores (RCMRCs) are accepting applications for exploratory biomedical research projects utilizing metabolomics technology. These "Pilot and Feasibility (P&F)" studies are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research. Please see our funding opportunities page for further details. Application deadline is March 16, 2017.

12-23-2016 - Renowned Scientist Joins Nutrition Research Institute - Susan Sumner, PhD has joined the University of Carolina Nutrition Research Institute as a Professor of Nutrition. For the past 12 years, Dr. Sumner has worked at the Research Triangle Institute as a Senior Scientist, and the PI/director of the NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC). With Dr. Sumner’s arrival in Kannapolis, the University of Carolina Nutrition Research Institute will be home to the Eastern Regional Comprehensive Metabolomics Research Core.

12-13-2016 - Novel Analytical Approaches for Metabolomics Data (R03) The National Institutes of Health (NIH) has developed a Common Fund initiative to foster collaboration between computational scientists, metabolomics experts, and biomedical researchers in developing, piloting, and/or validating novel bioinformatic approaches that address current analytical hurdles in metabolomics data. Projects are expected to use existing, publicly available metabolomics data and complement the efforts and resources of the Common Fund Metabolomics Program. See the Funding Opportunity Announcement (FOA) for further details.

11-04-2016 - New metabolomic screening method detects multiple inborn errors of metabolism in urine Analysis of a single urine sample using a metabolomics-based screening approach can identify multiple different inborn errors of metabolism (IEMs), facilitating early disease detection and rapid initiation of treatment, as described in an article published in Genetic Testing and Molecular Biomarkers.

11-02-2016 - Navigating an Ocean of Biological Data in the Modern Era Scientists and software engineers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have developed a new -omics visualization tool, Arrowland, which combines different realms of functional genomics data in a single intuitive interface. The aim of this system is to provide scientists an easier way to navigate the ever-growing amounts of biological data generated by the postgenomic revolution.

11-01-2016 - Agilent Technologies and PureHoney Technologies to Develop New Applications for RapidFire/MS System Agilent Technologies Inc. and PureHoney Technologies today announced a co-marketing agreement to develop new applications on the Agilent RapidFire 365 High-throughput Mass Spectrometry System. They will independently create new workflows for pharma and biopharma research, as well as forensic toxicology and metabolomics analysis.

10-24-2016 - How plants time their flowering - Professor Markus Schmid, Umeå University, Sweden, is leading a project to find out how flowering time is regulated on cell level. "By using advanced gene sequencing and metabolomics, we are hoping to gain new insights into the function of the genetic, regulatory networks, and also more knowledge on what controls the time of flowering."

10-17-2016 - Metabolomics Events - Visit the Metabolomics Workbench Events Calendar for the most comprehensive and up-to-date listing of metabolomics events — seminars, workshops, symposia, conferences, and congresses — on the Web!

10-13-2016 - Statistics Toolbox now accompanies each study - When viewing an individual study, you can now access a suite of analysis tools that enable you to perform a variety of statistical functions, including data normalization and averaging, hierarchial clustering, correlation heatmaps, ANOVA, volcano plots, multivariate analysis, random forest analysis and VIP plots as well as metabolite mapping to biochemical pathways.

09-03-2016 - NuSirt Biopharma and OWL Metabolomics Partner to Advance Treatment of NASH / Non-alcoholic Steatohepatitis - "NASHVILLE, Tenn. and DERIO, Spain, Sept. 20, 2016 /PRNewswire/ -- NuSirt Biopharma, a company dedicated to improving the lives of those with chronic metabolic diseases, and One Way Liver S.L. (OWL Metabolomics), a leader in the field of metabolomics and liver diseases diagnostics, today announced they have initiated a strategic partnership to develop novel diagnostic tools for ongoing drug evaluation trials for NuSirt's fatty liver drug research candidate, NS-0200. . . ."

09-03-2016 - CPRIT awards Baylor $5 million grant for core facility support in proteomics and metabolomics - "Baylor College of Medicine has received $5 million from the Cancer Prevention and Research Institute of Texas (CPRIT) for a renewal grant focused on core facility support in proteomics and metabolomics. . . ."

08-18-2016 - 9th Annual Course on Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis - November 7-11, 2016, Nashville, TN, USA. This is the ninth annual offering of a course that provides basic introductory and comprehensive information on performing metabolic studies using tracers labeled with radioactive or stable isotopes, in man and in animals. Futher details on our Events Calendar page.

08-16-2016 - 2016 Funded P&F Projects announced - Pilot and Feasibility (P&F) awards are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research, and to support projects that will provide preliminary data for new extramural proposal submission. This year's awardees have been selected and are listed on our Pilot and Feasibility Program page.

08-08-2016 - The NCI SBIR Program recently announced 15 new contract funding opportunities in a range of novel technology areas, including NIH/NCI 364: Methods and Software for Integration of Cancer Metabolomic Data with Other –Omic and Imaging Data. The deadline for receipt of all FY2017 contract topic proposals is October 21, 2016 by 5:00 PM ET. Read more on our funding opportunities page.

06-06-2016 - Human Metabolome Gene/Protein Database (MGP) - The Human Metabolome Gene/Protein Database (MGP) of metabolome-related genes and proteins is now available via the Metabolomics Workbench; MGP contains data for over 7300 genes and over 15,500 proteins.

05-04-2016 - Free Agilent and West Coast Metabolomics Center workshop - please register at http://www.agilent.com/chem/ucdavis.

02-25-2016 - UAB 4th Annual Workshop on Metabolomics - July 17 - 21, 2016, Birmingham, AL, USA
This course is jointly sponsored by the National Institute of General Medical Sciences (NIGMS) as part of the NIH Common Fund Metabolomics Initiative, and the Departments of Chemistry and Pharmacology and Toxicology at UAB. Topics covered range from design of a metabolomics experiment to advanced elective sessions (imaging mass spectrometry, isotope ratio analysis, ion mobility, command line and R programs)

02-25-2016 - Invitation to participate - The ABRF Metabolomics Research Group invites you to participate in its second study [on the current use of metabolomics technologies] with a focus on strategies for the analysis of metabolomics data collected with high resolution mass spectrometry. For study details and materials please consult Instructions_MRG2016 Data Analysis Study.pdf and Bioshare.

02-23-2016 - Position Announcement: Food and Nutritional Metabolomics Computational Biology Faculty - The Ohio State University (OSU), College of Food, Agricultural and Environmental Sciences, College of Education and Human Ecology and the College of Medicine invite applicants for a tenure-track position at the rank of assistant, associate or full professor (9 month) in Food and Nutritional Metabolomics Computational Biology. Download the position announcement.

01-15-2016 - The six Regional Comprehensive Metabolomics Research Cores (RCMRCs) are accepting applications for exploratory biomedical research projects utilizing metabolomics technology. These "Pilot and Feasibility (P&F) studies" are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research. Awards are intended to support projects that will provide preliminary data for new extramural proposal submission. Please see our funding opportunities page for further details. Application deadline is March 15, 2016.

12-22-2015 - Online data submission - We invite researchers to submit metabolomics data using our new web-based system. Please see the tutorial for step-by-step instructions. The new online interface is offered in addition to the option to submit data using Excel templates.

11-10-2015 - Metabolomics Data Analysis (R03) - The purpose of this small research grant Funding Opportunity Announcement (FOA) is to foster collaboration between bioinformaticians, metabolomics experts, and/or biomedical researchers in efforts to improve the ability to analyze metabolomics data to address biomedical questions. It is also expected that these grants would complement the current efforts of the Common Fund Metabolomics Program and maximize the value of existing metabolomics databases and resources.

10-13-2015 - Administrative Supplements for Collaborative Activities to Promote Metabolomics Research (PA-16-005) - These administrative supplements aim to support collaborative, multi-disciplinary research using metabolomics and to help expand the cadre of investigators experienced in metabolomics study design, analytical methodology, and data interpretation. These supplements will provide funds to current NIH-funded research projects for new collaborations between basic or clinical researchers and metabolomics experts to pursue biomedical studies requiring a metabolomics approach within the scope of the parent grant.

10-13-2015 - Funding Opportunity Announcements (FOAs) for the Molecular Transducers of Physical Activity in Humans Program have been released. These FOAs invite applications for the six scientific components of the Molecular Transducers of Physical Activity Consortium (MoTrPAC). The MoTrPAC is a national research consortium designed to discover and perform preliminary characterization of the range of molecular transducers (the ‘molecular map’) that underlie the effects of physical activity in humans.

10-06-2015 - Notice of Intent to Publish a Funding Opportunity Announcement for NLM Institutional Grants for Research Training in Biomedical Informatics and Data Science (T15) This FOA is expected to be published in the winter of 2016 with an expected application due date in the spring of 2016. See our funding opportunities page for more information on this and other funding opportunities.

09-10-2015 - Online Learning PlatformMetabolomics in Medicine, developed by Martin Kohlmeier from the University of North Carolina. Online instruction and other resources at this site will help researchers and clinicians to catch up with the rapid pace of development in the metabolomic sciences. The learning materials will teach the scientific foundations for understanding current technologies and analytical strategies. Supported by a NIH Common Fund Metabolomics Award (R25 GM103802). http://metabolomicsinmedicine.org/

07-14-2015 - Order Standards Now! As part of the NIH Common Fund's Metabolomics Program, the Metabolite Standards Synthesis Cores (MSSC) aim to provide metabolomics researchers with high quality, freely available metabolite standards. Several of these compounds have been synthesized and are now available for shipment.

07-02-2015 - The NIH Director's Blog recently featured the video, "Cool Videos: Battling Bad Biofilms" submitted by Metabolomics Consortium member Dr. Mary Cloud Ammons to the Common Fund Video Contest.

06-09-2015 - The 8th Annual Course on Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis - Announced

This is the 8th annual offering of a course that provides basic introductory and comprehensive information on performing metabolic studies using tracers labeled with radioactive or stable isotopes, in human and in animals. The course is designed for beginners as well as those with experience who wish to expand their capabilities to more sophisticated problems. The faculty is well-versed in a variety of applications and methodologies.
More info

05-27-2015 - The NIH Common Fund Metabolomics Program 2015 Annual Meeting will be held September 26-27, 2015 in Lexington, KY, USA. This is an invitation-only meeting for the NIH Common Fund Metabolomics Consortium.

05-27-2015 - Registration is still open for the 11th Annual International Conference of the Metabolomics Society, which will take place June 29-July 02, 2015 in San Francisco/Burlingame, CA, USA. The deadline for regular registration is May 30th, 2015, after which the price goes up! Don't miss this exciting meeting, with already over 700 registrants, 125 oral, and more 500 than poster presentations.

04-16-2015 - Jacquelyn Gosse represented the Mayo Clinic’s Metabolomics Resource Core at the Experimental Biology 2015 Exhibition at the Boston Convention Center on March 29-31. Almost 15,000 people attended the multidisciplinary, scientific meeting that featured plenary and award lectures, pre-meeting workshops, oral and posters sessions, on-site career services and exhibits of an array of informational booths, equipment, supplies and publications required for research labs and experimental study.

In addition to Mayo Clinic information, Ms. Gosse distributed the new NIH Common Fund Metabolomics Program flyer that shared information about the five other centers, which provided an opportunity for discussion based on where the attendee lived and which one was closest to them.

“We wanted to see if this idea would work – to bring our information to where a large group of researchers were already gathered,” said Ms. Gosse. “I had a goal of having direct and meaningful conversations with at least 100 people a day and I doubled that. There is great interest in this exciting area,” she said.

01-20-2015 - Call for Pilot and Feasibility Project Applications - The six Regional Comprehensive Metabolomics Research Cores (RCMRCs) are accepting applications for exploratory biomedical research projects utilizing metabolomics technology. Application deadline: March 16, 2014.

01-09-2015 - Submit your abstracts to Metabolomics 2015. The Metabolomics Society Meeting is hosting its annual meeting on June 29 - July 2, 2015 in San Francisco, CA. This is a great opportunity to see what’s new in metabolomics, share your latest results, and meet members of the international metabolomics community.

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