Summary of Study ST002559

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001651. The data can be accessed directly via it's Project DOI: 10.21228/M8971G This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study ID	ST002559
Study Title	The ECHO Cohort Exposome: First Steps using HHEAR Analysis – An Opportunity for ALL ECHO Cohorts to Contribute Type A Samples – Untargeted Analysis (VCSIP Cohort)
Study Type	Prospective Cohort Study
Study Summary	Maternal smoking during pregnancy negatively effects fetal lung development and causes lifelong decreases in offspring pulmonary function and offspring respiratory health including increased risk of childhood asthma development. The VCSIP cohort was created from 2 RCTs to determine if vitamin C supplementation to pregnant smokers could ameliorate some of the negative effects of maternal smoking during pregnancy on offspring lung health (JAMA 311:2074-2082, 2014; JAMA Pediatr 177:16-24, 2023). Both pre- and postnatal tobacco exposures have been carefully monitored and extensive respiratory phenotyping on the offspring have been performed. Please contact Cindy McEvoy at Mcevoyc@ohsu.edu for questions related to subject characteristics and outcomes. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. VCSIP is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
Institute	Oregon Health and Science University
Department	Division of Neuroscience
Last Name	Spindel
First Name	Eliot
Address	3181 SW Sam Jackson Park Road Portland, OR 97239-3098
Email	spindele@ohsu.edu
Phone	503-346-5524
Submit Date	2023-04-13
Total Subjects	200
Study Comments	HHEAR Project EM20-0011, ECHO Project EC0376
Raw Data Available	Yes
Raw Data File Type(s)	raw(Thermo)
Chear Study	Yes
Analysis Type Detail	LC-MS
Release Date	2024-04-14
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	Sample Type
SA257342	VCSIP_B_8	Blank \| Batch:1 \| Analysis Order:108
SA257343	VCSIP_B_1	Blank \| Batch:1 \| Analysis Order:12
SA257344	VCSIP_B_2	Blank \| Batch:1 \| Analysis Order:26
SA257345	VCSIP_B_3	Blank \| Batch:1 \| Analysis Order:39
SA257346	VCSIP_B_4	Blank \| Batch:1 \| Analysis Order:53
SA257347	VCSIP_B_5	Blank \| Batch:1 \| Analysis Order:67
SA257348	VCSIP_B_6	Blank \| Batch:1 \| Analysis Order:81
SA257349	VCSIP_B_7	Blank \| Batch:1 \| Analysis Order:94
SA257350	VCSIP_B_9	Blank \| Batch:2 \| Analysis Order:123
SA257351	VCSIP_B_10	Blank \| Batch:2 \| Analysis Order:137
SA257352	VCSIP_B_11	Blank \| Batch:2 \| Analysis Order:150
SA257353	VCSIP_B_12	Blank \| Batch:2 \| Analysis Order:164
SA257354	VCSIP_B_13	Blank \| Batch:2 \| Analysis Order:178
SA257355	VCSIP_B_14	Blank \| Batch:2 \| Analysis Order:192
SA257356	VCSIP_B_15	Blank \| Batch:2 \| Analysis Order:205
SA257357	VCSIP_B_16	Blank \| Batch:2 \| Analysis Order:219
SA257358	VCSIP_B_17	Blank \| Batch:3 \| Analysis Order:234
SA257359	VCSIP_B_18	Blank \| Batch:3 \| Analysis Order:248
SA257360	VCSIP_B_19	Blank \| Batch:3 \| Analysis Order:262
SA257361	VCSIP_B_20	Blank \| Batch:3 \| Analysis Order:276
SA257362	VCSIP_CHEAR_U_1	CHEAR Urine Pool \| Batch:1 \| Analysis Order:14
SA257363	VCSIP_CHEAR_U_2	CHEAR Urine Pool \| Batch:1 \| Analysis Order:41
SA257364	VCSIP_CHEAR_U_3	CHEAR Urine Pool \| Batch:1 \| Analysis Order:69
SA257365	VCSIP_CHEAR_U_4	CHEAR Urine Pool \| Batch:1 \| Analysis Order:96
SA257366	VCSIP_CHEAR_U_5	CHEAR Urine Pool \| Batch:2 \| Analysis Order:125
SA257367	VCSIP_CHEAR_U_6	CHEAR Urine Pool \| Batch:2 \| Analysis Order:152
SA257368	VCSIP_CHEAR_U_7	CHEAR Urine Pool \| Batch:2 \| Analysis Order:180
SA257369	VCSIP_CHEAR_U_8	CHEAR Urine Pool \| Batch:2 \| Analysis Order:207
SA257370	VCSIP_CHEAR_U_9	CHEAR Urine Pool \| Batch:3 \| Analysis Order:236
SA257371	VCSIP_CHEAR_U_10	CHEAR Urine Pool \| Batch:3 \| Analysis Order:264
SA257372	VCSIP_HHEAR_U1_1	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:1 \| Analysis Order:13
SA257373	VCSIP_HHEAR_U1_2	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:1 \| Analysis Order:40
SA257374	VCSIP_HHEAR_U1_3	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:1 \| Analysis Order:68
SA257375	VCSIP_HHEAR_U1_4	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:1 \| Analysis Order:95
SA257376	VCSIP_HHEAR_U1_5	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:2 \| Analysis Order:124
SA257377	VCSIP_HHEAR_U1_6	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:2 \| Analysis Order:151
SA257378	VCSIP_HHEAR_U1_7	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:2 \| Analysis Order:179
SA257379	VCSIP_HHEAR_U1_8	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:2 \| Analysis Order:206
SA257380	VCSIP_HHEAR_U1_9	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:3 \| Analysis Order:235
SA257381	VCSIP_HHEAR_U1_10	HHEAR Urine Pool 1 (HHEAR_U1_20) \| Batch:3 \| Analysis Order:263
SA257382	VCSIP_HHEAR_U2_4	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:1 \| Analysis Order:109
SA257383	VCSIP_HHEAR_U2_1	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:1 \| Analysis Order:27
SA257384	VCSIP_HHEAR_U2_2	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:1 \| Analysis Order:54
SA257385	VCSIP_HHEAR_U2_3	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:1 \| Analysis Order:82
SA257386	VCSIP_HHEAR_U2_5	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:2 \| Analysis Order:138
SA257387	VCSIP_HHEAR_U2_6	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:2 \| Analysis Order:165
SA257388	VCSIP_HHEAR_U2_7	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:2 \| Analysis Order:193
SA257389	VCSIP_HHEAR_U2_8	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:2 \| Analysis Order:220
SA257390	VCSIP_HHEAR_U2_9	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:3 \| Analysis Order:249
SA257391	VCSIP_HHEAR_U2_10	HHEAR Urine Pool 2 (HHEAR_U2_50) \| Batch:3 \| Analysis Order:277
SA257392	VCSIP_NIST_3672_1	NIST Urine Pool 3672 \| Batch:1 \| Analysis Order:1
SA257393	VCSIP_NIST_3672_3	NIST Urine Pool 3672 \| Batch:1 \| Analysis Order:111
SA257394	VCSIP_NIST_3672_2	NIST Urine Pool 3672 \| Batch:1 \| Analysis Order:56
SA257395	VCSIP_NIST_3672_4	NIST Urine Pool 3672 \| Batch:2 \| Analysis Order:112
SA257396	VCSIP_NIST_3672_5	NIST Urine Pool 3672 \| Batch:2 \| Analysis Order:167
SA257397	VCSIP_NIST_3672_6	NIST Urine Pool 3672 \| Batch:2 \| Analysis Order:222
SA257398	VCSIP_NIST_3672_7	NIST Urine Pool 3672 \| Batch:3 \| Analysis Order:223
SA257399	VCSIP_NIST_3672_8	NIST Urine Pool 3672 \| Batch:3 \| Analysis Order:251
SA257400	VCSIP_NIST_3672_9	NIST Urine Pool 3672 \| Batch:3 \| Analysis Order:279
SA257401	VCSIP_SP_8	Study Pool \| Batch:1 \| Analysis Order:110
SA257402	VCSIP_SP_1	Study Pool \| Batch:1 \| Analysis Order:15
SA257403	VCSIP_SP_2	Study Pool \| Batch:1 \| Analysis Order:28
SA257404	VCSIP_SP_3	Study Pool \| Batch:1 \| Analysis Order:42
SA257405	VCSIP_SP_4	Study Pool \| Batch:1 \| Analysis Order:55
SA257406	VCSIP_SP_5	Study Pool \| Batch:1 \| Analysis Order:70
SA257407	VCSIP_SP_6	Study Pool \| Batch:1 \| Analysis Order:83
SA257408	VCSIP_SP_7	Study Pool \| Batch:1 \| Analysis Order:97
SA257409	VCSIP_SP_9	Study Pool \| Batch:2 \| Analysis Order:126
SA257410	VCSIP_SP_10	Study Pool \| Batch:2 \| Analysis Order:139
SA257411	VCSIP_SP_11	Study Pool \| Batch:2 \| Analysis Order:153
SA257412	VCSIP_SP_12	Study Pool \| Batch:2 \| Analysis Order:166
SA257413	VCSIP_SP_13	Study Pool \| Batch:2 \| Analysis Order:181
SA257414	VCSIP_SP_14	Study Pool \| Batch:2 \| Analysis Order:194
SA257415	VCSIP_SP_15	Study Pool \| Batch:2 \| Analysis Order:208
SA257416	VCSIP_SP_16	Study Pool \| Batch:2 \| Analysis Order:221
SA257417	VCSIP_SP_17	Study Pool \| Batch:3 \| Analysis Order:237
SA257418	VCSIP_SP_18	Study Pool \| Batch:3 \| Analysis Order:250
SA257419	VCSIP_SP_19	Study Pool \| Batch:3 \| Analysis Order:265
SA257420	VCSIP_SP_20	Study Pool \| Batch:3 \| Analysis Order:278
SA257421	VCSIP_S_9	Study Sample \| Batch:1 \| Analysis Order:10
SA257422	VCSIP_S_73	Study Sample \| Batch:1 \| Analysis Order:100
SA257423	VCSIP_S_74	Study Sample \| Batch:1 \| Analysis Order:101
SA257424	VCSIP_S_75	Study Sample \| Batch:1 \| Analysis Order:102
SA257425	VCSIP_S_76	Study Sample \| Batch:1 \| Analysis Order:103
SA257426	VCSIP_S_77	Study Sample \| Batch:1 \| Analysis Order:104
SA257427	VCSIP_S_78	Study Sample \| Batch:1 \| Analysis Order:105
SA257428	VCSIP_S_79	Study Sample \| Batch:1 \| Analysis Order:106
SA257429	VCSIP_S_80	Study Sample \| Batch:1 \| Analysis Order:107
SA257430	VCSIP_S_10	Study Sample \| Batch:1 \| Analysis Order:11
SA257431	VCSIP_S_11	Study Sample \| Batch:1 \| Analysis Order:16
SA257432	VCSIP_S_12	Study Sample \| Batch:1 \| Analysis Order:17
SA257433	VCSIP_S_13	Study Sample \| Batch:1 \| Analysis Order:18
SA257434	VCSIP_S_14	Study Sample \| Batch:1 \| Analysis Order:19
SA257435	VCSIP_S_1	Study Sample \| Batch:1 \| Analysis Order:2
SA257436	VCSIP_S_15	Study Sample \| Batch:1 \| Analysis Order:20
SA257437	VCSIP_S_16	Study Sample \| Batch:1 \| Analysis Order:21
SA257438	VCSIP_S_17	Study Sample \| Batch:1 \| Analysis Order:22
SA257439	VCSIP_S_18	Study Sample \| Batch:1 \| Analysis Order:23
SA257440	VCSIP_S_19	Study Sample \| Batch:1 \| Analysis Order:24
SA257441	VCSIP_S_20	Study Sample \| Batch:1 \| Analysis Order:25