Summary of project PR001927

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001927. The data can be accessed directly via it's Project DOI: 10.21228/M8N42X This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001927
Project DOI:doi: 10.21228/M8N42X
Project Title:The Human Cardiac “Age-OME”: Age-specific changes in myocardial molecular expression
Project Type:MS analysis
Project Summary:A substantial proportion of the World’s population is ageing. One of the most significant risk factors for heart disease is ageing. However, we do not understand how the human heart changes with age. Taking advantage of a unique set of pre-mortem, cryopreserved, non-diseased human hearts, we performed multi-omic analyses (transcriptomics, proteomics, metabolomics and lipidomics), coupled with biological computational modelling in younger (<25 years old) and older hearts (>50years old) to describe the molecular landscape of human cardiac ageing. In older hearts, we observed a downregulation of proteins involved in calcium signalling and of the contractile apparatus itself. In addition, we found a potential counteractive upregulation of central carbon generation of fuel, upregulation of glycolysis and increases in long-chain fatty acids. This is the first molecular data set of normal human cardiac ageing, which may have important implications for the development of age-related heart disease.
Institute:University of Sydney
Department:School of Medical Sciences
Laboratory:Cardiometabolic Medicine
Last Name:Koay
First Name:Yen Chin
Address:The Hub, Charles Perkins Centre, D17, The University of Sydney, NSW, 2006
Email:yen.koay@sydney.edu.au
Phone:+61486275851

Summary of all studies in project PR001927

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST003104 Metabolomics studies on human cardiac samples Homo sapiens University of Sydney MS 2024-03-11 1 25 Uploaded data (9.8M)*
ST003168 Lipidomic analysis of cryopreserved human cardiac tissue from young and ageing adults Homo sapiens University of Sydney MS* 2024-05-03 1 23 Uploaded data (32.4G)*
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