Summary of project PR001938
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001938. The data can be accessed directly via it's Project DOI: 10.21228/M86T69 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001938 |
| Project DOI: | doi: 10.21228/M86T69 |
| Project Title: | Role of central carbon metabolism in embryonic development |
| Project Summary: | This work aims to understand how central carbon metabolism plays a crucial role in germ layer fate specification and morphogenesis during gastrulation. In this project, we manipulated central carbon metabolism using different glucose concentrations and its inhibitors. To understand developmental phenotype of such manipulations, we analysed the levels of intermediates of the glycolytic pathway, oxidative phosphorylation, hexosamine biosynthetic pathway etc as well as glucose epimers such as fucose, mannose, galactose. We later tested how changes in these metabolite levels affected signalling pathways, important in germ layer fate specification and subsequently their morphogenesis. |
| Institute: | Dept of Genetics, University of Cambridge |
| Last Name: | Dingare |
| First Name: | Chaitanya |
| Address: | Downing Site, Cambridge, Cambridgeshire, CB2 3EH, United Kingdom |
| Email: | cd705@cam.ac.uk |
| Phone: | +447916677460 |
Summary of all studies in project PR001938
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003120 | Mannose is crucial for mesoderm specification and symmetry breaking in gastruloids. | Mus musculus | Dept of Genetics, University of Cambridge | MS* | 2024-03-13 | 1 | 22 | Uploaded data (9.2G)* |
