Summary of Study ST001042

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000698. The data can be accessed directly via it's Project DOI: 10.21228/M8FT3B This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001042
Study TitleNon-targeted serum metabolomic profiling of prostate cancer patients (FI-TWIM-MS PCa )
Study SummaryNon-targeted metabolomics study of serum samples from prostate cancer and healthy individuals using flow injection ion mobility mass spectrometry
Institute
Georgia Institute of Technology
Last NameZang
First NameXiaoling
Address901 Atlantic Drive Atlanta, GA 30332-0400
Emailxzang3@gatech.edu
Phone4043850381
Submit Date2018-06-07
Analysis Type DetailFIA-MS
Release Date2019-07-17
Release Version1
Xiaoling Zang Xiaoling Zang
https://dx.doi.org/10.21228/M8FT3B
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000698
Project DOI:doi: 10.21228/M8FT3B
Project Title:Non-targeted serum metabolomic profiling of prostate cancer patients (FI-TWIM-MS PCa )
Project Summary:Flow injection ion mobility mass spectrometry data for non-targeted serum metabolomic profiling of prostate cancer patients and healthy individuals
Institute:Georgia Institute of Technology
Last Name:Zang
First Name:Xiaoling
Address:901 Atlantic Drive Atlanta, GA 30332-0400
Email:xzang3@gatech.edu
Phone:404-385-0381

Subject:

Subject ID:SU001081
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Class
SA070118116CCancer
SA07011996CCancer
SA070120148CCancer
SA07012198CCancer
SA07012272CCancer
SA070123166CCancer
SA07012417CCancer
SA07012520CCancer
SA07012636CCancer
SA07012760CCancer
SA070128140CCancer
SA07012964CCancer
SA070130122CCancer
SA070131114CCancer
SA070132112CCancer
SA070133130CCancer
SA0701341CCancer
SA07013574CCancer
SA07013621CCancer
SA070137142CCancer
SA070138100CCancer
SA07013952CCancer
SA070140170CCancer
SA070141118CCancer
SA070142108CCancer
SA07014314CCancer
SA070144144CCancer
SA070145110CCancer
SA07014648CCancer
SA070147156CCancer
SA07014835CCancer
SA070149160CCancer
SA07015045CCancer
SA07015158CCancer
SA07015292CCancer
SA070153150CCancer
SA07015470CCancer
SA070155120CCancer
SA070156172CCancer
SA070157134CCancer
SA070158158CCancer
SA070159152CCancer
SA070160164CCancer
SA07016166CCancer
SA070162168CCancer
SA0701633CCancer
SA070164136CCancer
SA07016534CCancer
SA07016694CCancer
SA070167146CCancer
SA07016881CCancer
SA070169132CCancer
SA07017068CCancer
SA070171154CCancer
SA07017256CCancer
SA07017310CCancer
SA07017454CCancer
SA07017588CCancer
SA0701769CCancer
SA07017762CCancer
SA07017878CCancer
SA07017940HHealthy
SA07018049HHealthy
SA07018145HHealthy
SA07018233HHealthy
SA07018341HHealthy
SA07018423HHealthy
SA07018535HHealthy
SA07018644HHealthy
SA07018728HHealthy
SA0701888HHealthy
SA07018956HHealthy
SA07019034HHealthy
SA07019152HHealthy
SA07019237HHealthy
SA0701936HHealthy
SA0701947HHealthy
SA07019513HHealthy
SA07019610HHealthy
SA07019711HHealthy
SA07019831HHealthy
SA0701999HHealthy
SA07020046HHealthy
SA07020150HHealthy
SA07020227HHealthy
SA07020317HHealthy
SA07020430HHealthy
SA07020521HHealthy
SA07020615HHealthy
SA07020747HHealthy
SA07020839HHealthy
SA07020919HHealthy
SA07021016HHealthy
SA07021120HHealthy
SA07021242HHealthy
SA07021312HHealthy
SA07021457HHealthy
SA07021529HHealthy
SA07021655HHealthy
SA07021748HHealthy
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Collection:

Collection ID:CO001075
Collection Summary:After approval by the Institutional Review Board (IRB), blood samples were collected at Saint Joseph’s Hospital of Atlanta (GA, USA) by venipuncture from each donor into evacuated blood collection tubes that contained no anticoagulant. Serum was obtained by centrifugation at 5000 rpm for 5 min at 4 °C. Immediately after centrifugation, 200 μL aliquots of serum were frozen and stored at −80 °C for further use. The sample collection and storage procedures for PCa patients and controls were identical.
Sample Type:Blood (serum)

Treatment:

Treatment ID:TR001095
Treatment Summary:Prostate cancer patients and healthy individuals

Sample Preparation:

Sampleprep ID:SP001088
Sampleprep Summary:Frozen serum samples were thawed on ice, and 300 µL of extraction solution (acetone: acetonitrile: methanol 1:1:1, cooled to -20 ˚C) was added to 100 µL of serum. Samples were vortex-mixed for 20 s and centrifuged at 16,000 × g for 5 min to pellet proteins. To remove most lipids and other non-polar metabolites, 800 µL of dichloromethane was added to ~350 µL of supernatant and vortex-mixed. Following the addition of 250 µL deionized water, samples were vortex-mixed and kept on ice for 10 min. The aqueous phase was subject to FI-TWIM-MS analysis. Sample blanks were prepared using deionized water instead of serum following the same procedure.

Combined analysis:

Analysis ID AN001705
Analysis type MS
Chromatography type None (Direct infusion)
Chromatography system Waters
Column none
MS Type ESI
MS instrument type QTOF
MS instrument name Waters Synapt G2
Ion Mode NEGATIVE
Units peak area

Chromatography:

Chromatography ID:CH001203
Instrument Name:Waters
Column Name:none
Chromatography Type:None (Direct infusion)

MS:

MS ID:MS001579
Analysis ID:AN001705
Instrument Name:Waters Synapt G2
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
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