Summary of Study ST001831

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001155. The data can be accessed directly via it's Project DOI: 10.21228/M8DH5P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001831
Study TitleNested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort (part II)
Study TypeObservational
Study SummaryPreterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI
Emailmkachman@med.umich.edu
Phone734-232-0842
Submit Date2021-06-15
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2021-12-15
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8DH5P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001155
Project DOI:doi: 10.21228/M8DH5P
Project Title:Nested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort.
Project Summary:Preterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth.
Institute:University of Michigan
Department:Nutritional Sciences
Laboratory:Meeker Lab
Last Name:Meeker
First Name:John
Address:Ann Arbor, MI
Email:meekerj@umich.edu
Phone:734-764-7184

Subject:

Subject ID:SU001908
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id PRETERM BIRTH
SA170237Sample2605NO
SA170238Sample2603NO
SA170239Sample2599NO
SA170240Sample2608NO
SA170241Sample2622NO
SA170242Sample2794NO
SA170243Sample2765NO
SA170244Sample2597NO
SA170245Sample2609NO
SA170246Sample2590NO
SA170247Sample2580NO
SA170248Sample2578NO
SA170249Sample2577NO
SA170250Sample2582NO
SA170251Sample2584NO
SA170252Sample3002NO
SA170253Sample2589NO
SA170254Sample2585NO
SA170255Sample2591NO
SA170256Sample3080NO
SA170257Sample7023NO
SA170258Sample7013NO
SA170259Sample7012NO
SA170260Sample7037NO
SA170261Sample7045NO
SA170262Sample7130NO
SA170263Sample7121NO
SA170264Sample7118NO
SA170265Sample7001NO
SA170266Sample7000NO
SA170267Sample3082NO
SA170268Sample3081NO
SA170269Sample2576NO
SA170270Sample3083NO
SA170271Sample3116NO
SA170272Sample6019NO
SA170273Sample3123NO
SA170274Sample3117NO
SA170275Sample3079NO
SA170276Sample2592NO
SA170277Sample2172NO
SA170278Sample2166NO
SA170279Sample2149NO
SA170280Sample2573NO
SA170281Sample2207NO
SA170282Sample2310NO
SA170283Sample2305NO
SA170284Sample2144NO
SA170285Sample2125NO
SA170286Sample1006NO
SA170287Sample1001NO
SA170288Sample1042NO
SA170289Sample2012NO
SA170290Sample2044NO
SA170291Sample2038NO
SA170292Sample2319NO
SA170293Sample2177NO
SA170294Sample2555NO
SA170295Sample2551NO
SA170296Sample2329NO
SA170297Sample2339NO
SA170298Sample2350NO
SA170299Sample2324NO
SA170300Sample2344NO
SA170301Sample2320NO
SA170302Sample2558NO
SA170303Sample2321NO
SA170304Sample2342NO
SA170305Sample2327NO
SA170306Sample2037YES
SA170307Sample2017YES
SA170308Sample2010YES
SA170309Sample1019YES
SA170310Sample7138YES
SA170311Sample7141YES
SA170312Sample7148YES
SA170313Sample7128YES
SA170314Sample7122YES
SA170315Sample1021YES
SA170316Sample6021YES
SA170317Sample7115YES
SA170318Sample3144YES
SA170319Sample3037YES
SA170320Sample3059YES
SA170321Sample3061YES
SA170322Sample3034YES
SA170323Sample3012YES
SA170324Sample2680YES
SA170325Sample2792YES
SA170326Sample2284YES
SA170327Sample2325YES
SA170328Sample2596YES
SA170329Sample2616YES
SA170330Sample3146YES
SA170331Sample3156YES
SA170332Sample3136YES
SA170333Sample2128YES
SA170334Sample0002YES
SA170335Sample2135YES
SA170336Sample2115YES
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Collection:

Collection ID:CO001901
Collection Summary:Standard blood plasma collection protocol
Sample Type:Blood (plasma)
Storage Conditions:-80℃

Treatment:

Treatment ID:TR001921
Treatment Summary:This is an observational study, no specific treatment was applied.

Sample Preparation:

Sampleprep ID:SP001914
Sampleprep Summary:Standard MRC2 lipidomics sample preparation protocol
Sampleprep Protocol Filename:Shotgun_Lipidomics.PDF

Combined analysis:

Analysis ID AN002972 AN002973
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Shimadzu 20AD Shimadzu 20AD
Column Waters Acquity BEH HSS T3 (50 x 2.1mm,1.8um) Waters Acquity BEH HSS T3 (50 x 2.1mm,1.8um)
MS Type ESI ESI
MS instrument type Triple TOF Triple TOF
MS instrument name ABI Sciex 5600+ TripleTOF ABI Sciex 5600+ TripleTOF
Ion Mode POSITIVE NEGATIVE
Units Peak area Peak area

Chromatography:

Chromatography ID:CH002201
Instrument Name:Shimadzu 20AD
Column Name:Waters Acquity BEH HSS T3 (50 x 2.1mm,1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH002202
Instrument Name:Shimadzu 20AD
Column Name:Waters Acquity BEH HSS T3 (50 x 2.1mm,1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS002762
Analysis ID:AN002972
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
MS Comments:In-house data processing pipeline
Ion Mode:POSITIVE
  
MS ID:MS002763
Analysis ID:AN002973
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
MS Comments:In-house data processing pipeline
Ion Mode:NEGATIVE
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