Data for ST003112
| Metabolite structure | All data | F1 | F2 | F3 |
|---|---|---|---|---|
| 1-Methyladenosine | 19556.08 | 16746.45 | 14111.67 | |
| 1-Methylnicotinamide | 1945874.51 | 2307214.29 | 1689162.50 | |
| 2DG | - | - | - | |
| 2DGP | 3381391.43 | 177266.65 | 211956.27 | |
| 2-Hydroxycaproic acid | 903888.79 | 567832.79 | 815322.00 | |
| 2-Hydroxyvaleric acid | 1894247.14 | 1946166.11 | 1926664.67 | |
| 3-Hydroxymethylglutaric acid | 6474666.29 | 5535791.00 | 6446685.83 | |
| 3-Indolepropionic acid | 5743.42 | 5061.98 | 5497.34 | |
| 3-Methylhistidine | 4224222.43 | 4679968.71 | 5864539.00 | |
| 3-Phosphoglyceric acid | 377568.80 | 321119.99 | 457781.03 | |
| 4-Acetamidobutanoic acid | - | - | - | |
| 4-Hydroxyproline | - | - | - | |
| 4-Pyridoxic acid | 211056.56 | 184370.61 | 217513.17 | |
| 4-Trimethylammoniobutanoic acid | 11492030.71 | 6319373.43 | 7726736.67 | |
| 5-Thymidylic acid | - | - | - | |
| 6-Phosphogluconic acid | 64712.72 | 93323.05 | 136286.87 | |
| 6-Phosphonoglucono-D-lactone | - | - | - | |
| Acetylcholine | 14600173.71 | 17411742.57 | 12047787.83 | |
| Acetyl-CoA | 130680.92 | 115099.07 | 118870.91 | |
| Acetylcysteine | - | - | - | |
| Adenine | 42753642.86 | 42293462.86 | 44851503.33 | |
| Adenosine | 297792214.29 | 331088057.14 | 328843466.67 | |
| Adenosine monophosphate | 67825280.00 | 66409908.57 | 88384563.33 | |
| Adenosine triphosphate | 98006.79 | 99610.36 | 200716.42 | |
| ADP | 3069888.00 | 2507427.71 | 3795424.50 | |
| ADP-glucose | 111604.84 | 99547.17 | 134241.93 | |
| AICAR | 54647.05 | 33474.07 | 47367.57 | |
| Allantoin | 687617.64 | 516300.56 | 625160.95 | |
| Aminoadipic acid | 1340743.63 | 1180495.96 | 1721582.50 | |
| Argininosuccinic acid | 357731.81 | 270051.40 | 298565.58 | |
| Ascorbic acid | - | - | - | |
| Asymmetric dimethylarginine | 473595.66 | 431170.40 | 358674.13 | |
| Betaine | 89473988.57 | 108502231.43 | 120077328.33 | |
| Butyrylcarnitine | 7044221.86 | 5744929.14 | 6925030.00 | |
| Caprylic acid | 1366583.19 | 359908.11 | 1143112.00 | |
| Carnosine | 32537041.43 | 22785075.14 | 16834233.33 | |
| CDP | 11216.94 | 12628.06 | 8826.29 | |
| CDP-Ethanolamine | 1868567.14 | 1723791.84 | 1840671.00 | |
| Choline | 190195071.43 | 144666157.14 | 114055238.33 | |
| cis-Aconitic acid | 10170566.29 | 7684673.14 | 8127813.33 | |
| Citicoline | 3159521.57 | 2886084.57 | 3058509.67 | |
| Citric acid | 54200952.86 | 41645400.00 | 48908323.33 | |
| Citrulline | 8483887.29 | 7258106.00 | 8256778.17 | |
| Coenzyme A | 409142.70 | 411618.49 | 492724.37 | |
| Creatine | 971435357.14 | 930944942.86 | 948902350.00 | |
| Creatinine | 88965914.29 | 82491162.86 | 92393598.33 | |
| Cyclic AMP | 51391.65 | 45946.55 | 48504.39 | |
| Cytidine | 5967683.00 | 5700987.29 | 8067641.67 | |
| Cytidine monophosphate | 1013099.84 | 939663.96 | 979104.68 | |
| Cytidine triphosphate | - | - | - | |
| Cytosine | 187590.37 | 145950.03 | 220486.32 | |
| D-2-Hydroxyglutaric acid | 16304275.71 | 14072896.86 | 16163278.33 | |
| dCDP | - | - | - | |
| dCMP | - | - | - | |
| dCTP | - | - | - | |
| Deoxyadenosine | 165068.44 | 152944.46 | 214992.57 | |
| Deoxyadenosine monophosphate | - | - | - | |
| Deoxyadenosine triphosphate | - | - | - | |
| Deoxyinosine | 75379.60 | 21791.01 | 43478.72 | |
| Deoxyribose 5-phosphate | 22908.01 | 22106.79 | 16835.47 | |
| Deoxyuridine | 237673.24 | 174060.75 | 248033.38 | |
| D-Erythrose 4-phosphate | - | - | - | |
| D-Fructose | 208594.16 | 283220.23 | 241705.08 | |
| D-Glucose | 776742.40 | 910370.17 | 1360553.57 | |
| D-Glucuronic acid | 149272.45 | 49919.38 | 17150.11 | |
| D-Glyceraldehyde 3-phosphate | 867885.39 | 400092.27 | 261312.03 | |
| D-Ribose | 185824.73 | 180128.58 | 187787.63 | |
| D-Ribose 5-phosphate | 3170073.86 | 2853396.43 | 3261001.83 | |
| D-Ribulose | 28722.64 | 32052.06 | 31600.55 | |
| D-Ribulose 5-phosphate | 10177517.00 | 7751067.71 | 8069541.33 | |
| D-Sedoheptulose 7-phosphate | 1172794.79 | 1543645.71 | 1020155.58 | |
| FAD | 121630.77 | 146332.69 | 126797.13 | |
| Flavin Mononucleotide | - | - | - | |
| "Fructose 1,6-bisphosphate" | 132451.94 | 53483.26 | 121614.77 | |
| Fructose 6-phosphate | 1054503.91 | 810588.10 | 1030331.40 | |
| Fumaric acid | 14482454.29 | 12205312.29 | 16795893.33 | |
| Galactonic acid | 695415.93 | 1281043.59 | 1403846.47 | |
| GDP-glucose | 253743.66 | 239247.20 | 300479.95 | |
| Gluconic acid | 1373651.43 | 3288782.14 | 2797823.50 | |
| Glucosamine | - | - | - | |
| Glucosamine 6-phosphate | 69555.84 | 73498.12 | 78263.22 | |
| Glucose 6-phosphate | 1857676.76 | 1843760.01 | 3389166.50 | |
| Glutathione | 58650622.86 | 56053295.71 | 63876140.00 | |
| Glycerol 3-phosphate | 7536074.29 | 10821834.96 | 8009826.33 | |
| Glycerophosphocholine | 102160088.57 | 95257532.86 | 105835526.67 | |
| Glycine | 1941621.43 | 1650848.90 | 1770018.17 | |
| Guanidoacetic acid | 68163.74 | 59237.53 | 68282.22 | |
| Guanine | 1680601.29 | 1702279.61 | 1343195.80 | |
| Guanosine | 3130975.57 | 3003602.14 | 2554307.33 | |
| Guanosine diphosphate | 974352.76 | 780024.89 | 1425094.45 | |
| Guanosine monophosphate | 7991849.43 | 6856339.29 | 9239520.50 | |
| Guanosine triphosphate | 28711.95 | 31367.51 | 70311.14 | |
| Hexanoylcarnitine | 111794.94 | 79754.64 | 103158.34 | |
| Hippuric acid | 161287.49 | 110305.72 | 258603.22 | |
| Homocysteine | - | - | - | |
| Hypotaurine | 178500.97 | 152595.73 | 173818.38 | |
| Hypoxanthine | 63766198.57 | 67636374.29 | 68144596.67 | |
| IDP | - | - | - | |
| Imidazoleacetic acid | 438967.39 | 316572.44 | 368953.38 | |
| Indole | - | - | - | |
| Indolelactic acid | - | - | - | |
| Indoxyl sulfate | 113110.06 | 84113.39 | 154725.84 | |
| Inosine | 33337318.57 | 30353390.00 | 22309265.00 | |
| Inosinic acid | 4292832.14 | 3136353.71 | 3974280.67 | |
| Isovalerylcarnitine | 1523412.71 | 1042151.00 | 1165108.00 | |
| Kynurenic acid | 20587.55 | 15833.06 | 16923.93 | |
| L-Acetylcarnitine | 273315585.71 | 234443142.86 | 239091950.00 | |
| L-Alanine | 13770945.71 | 12397468.14 | 13967605.00 | |
| L-Arginine | 53940040.00 | 44972421.43 | 40321226.67 | |
| L-Asparagine | 5334812.86 | 5012200.14 | 5085582.17 | |
| L-Aspartic acid | 63876955.71 | 61037825.71 | 58938778.33 | |
| L-Carnitine | 255190542.86 | 232190914.29 | 269078650.00 | |
| L-Cystathionine | 1836113.96 | 1519664.84 | 1398646.42 | |
| L-Cysteine | - | - | - | |
| L-Cystine | 371668.67 | 273668.37 | 189842.07 | |
| L-Dihydroorotic acid | - | - | - | |
| L-Glutamic acid | 710881042.86 | 651542542.86 | 728895183.33 | |
| L-Glutamine | 427397057.14 | 380868314.29 | 393156016.67 | |
| L-Glyceric acid | 1595985.71 | 1575908.93 | 1739663.17 | |
| L-Histidine | 13689915.00 | 12854623.00 | 13220063.50 | |
| L-Homoserine | 9250255.43 | 8788439.43 | 9341624.33 | |
| L-Isoleucine | 11508351.86 | 17643579.57 | 13102153.00 | |
| L-Kynurenine | - | - | - | |
| L-Lactic acid | 461167242.86 | 403622285.71 | 426118883.33 | |
| L-Leucine | 27892900.00 | 26196612.86 | 26136266.67 | |
| L-Lysine | 17311037.14 | 15235544.29 | 12859293.33 | |
| L-Methionine | 17057990.00 | 13306158.86 | 15518498.67 | |
| L-Palmitoylcarnitine | - | - | - | |
| L-Phenylalanine | 27009437.14 | 19618579.57 | 19930681.67 | |
| L-Pipecolic acid | 2382756.57 | 2866110.29 | 3707409.67 | |
| L-Proline | 59244792.86 | 68336995.71 | 86751406.67 | |
| L-Serine | 13436680.00 | 10115202.00 | 10545487.00 | |
| L-Threonine | 21227272.86 | 21675168.57 | 22373086.67 | |
| L-Tryptophan | 3369297.43 | 2669967.43 | 2771210.83 | |
| L-Tyrosine | 8156896.29 | 6167451.29 | 7185600.83 | |
| L-Valine | 16860057.14 | 16607114.43 | 18599086.67 | |
| Malic acid | 155026428.57 | 136260181.43 | 167740583.33 | |
| Myoinositol | 30191527.14 | 30830167.14 | 32776970.00 | |
| N6-Acetyl-L-lysine | 769421.33 | 447049.09 | 455301.05 | |
| "N6,N6,N6-Trimethyl-L-lysine" | 16295395.71 | 15780979.00 | 17862901.67 | |
| N-Acetylasparagine | 273145.51 | 314041.36 | 374204.03 | |
| N-Acetylaspartylglutamic acid | 17620242.86 | 13288532.00 | 13740737.00 | |
| N-Acetyl-D-glucosamine | 77229.49 | 58162.02 | 67724.29 | |
| N-Acetyl-glucosamine 1-phosphate | 564059.46 | 426491.26 | 545034.53 | |
| N-Acetylglutamic acid | 2817905.86 | 2303505.43 | 2574896.67 | |
| N-Acetylglutamine | 797904.39 | 354273.09 | 574761.83 | |
| N-Acetyl-L-alanine | 866881.61 | 705313.01 | 684070.08 | |
| N-Acetyl-L-aspartic acid | 807275657.14 | 735833000.00 | 801554166.67 | |
| N-Acetyl-L-methionine | 3003509.14 | 3259308.29 | 2481143.17 | |
| N-Acetylornithine | 252157.09 | 210351.20 | 279487.65 | |
| N-Acetylputrescine | - | - | - | |
| N-acetyltryptophan | 6623.57 | 3841.68 | 4422.11 | |
| NAD | 2434099.06 | 1905505.29 | 3424220.50 | |
| NADH | 82098.66 | 50365.67 | 82404.12 | |
| NADP | 49371.03 | 41208.72 | 95545.72 | |
| NADPH | 33035.63 | 36126.10 | 54478.50 | |
| N-Formyl-L-methionine | 186211.64 | 160473.81 | 209055.48 | |
| Niacinamide | 61240640.00 | 76470750.00 | 62428640.00 | |
| Nicotinamide riboside | 610807.80 | 534533.61 | 564172.82 | |
| Nicotinamide ribotide | 84570.96 | 72495.12 | 105419.94 | |
| Nicotinic acid | - | - | - | |
| Nicotinic acid adenine dinucleotide | - | - | - | |
| Nicotinic acid mononucleotide | - | - | - | |
| O-Phosphoethanolamine | 38064315.71 | 37586324.29 | 46067833.33 | |
| Ornithine | 763548.11 | 1611293.01 | 699309.62 | |
| Orotic acid | 1086370.39 | 1186810.89 | 1583182.72 | |
| Oxalacetic acid | - | - | - | |
| Oxidized glutathione | 1567143.76 | 1658024.66 | 1189114.80 | |
| Oxoglutaric acid | 1694252.57 | 1424460.07 | 3345683.00 | |
| Palmitic acid | - | - | - | |
| Pantothenic acid | 27542762.43 | 8652714.00 | 10583245.17 | |
| Phosphocreatine | 158149.01 | 161931.16 | 122237.01 | |
| Phosphoenolpyruvic acid | 563120.89 | 453294.66 | 734956.48 | |
| Phosphorylcholine | 303872257.14 | 354561728.57 | 401570683.33 | |
| Phosphoserine | 18610.30 | 19411.81 | 20831.15 | |
| Propionylcarnitine | 13209780.43 | 9944885.71 | 13283215.33 | |
| Purine | 20538.39 | 19029.46 | 16787.05 | |
| Pyridoxine | - | - | - | |
| Pyroglutamic acid | 23118401.43 | 22617764.29 | 22317476.67 | |
| Pyruvic acid | 885329.06 | 644569.90 | 1110163.97 | |
| Riboflavin | 71501.25 | 56120.92 | 69628.41 | |
| S-Adenosylhomocysteine | 831032.79 | 943860.87 | 1014245.70 | |
| S-Adenosylmethionine | 5300267.43 | 4972891.57 | 5099555.00 | |
| "Sedoheptulose 1,7-bisphosphate" | 13620.19 | 11145.06 | 13595.31 | |
| Succinic acid | 21800663.43 | 23361239.00 | 22476321.00 | |
| Succinyl-CoA | - | - | - | |
| Taurine | 272230757.14 | 248048914.29 | 256123383.33 | |
| Thiamine | 614453.84 | 637316.96 | 633165.85 | |
| Thiamine monophosphate | 441657.34 | 423857.89 | 343816.38 | |
| Thymidine | 214607.54 | 146521.11 | 197467.53 | |
| Thymidine 5^-triphosphate | - | - | - | |
| Thymine | 144138.67 | 99105.66 | 117524.43 | |
| Uracil | 8208154.00 | 6051261.14 | 6575574.17 | |
| Ureidopropionic acid | 490699.77 | 478587.93 | 501687.22 | |
| Ureidosuccinic acid | 35077.61 | 30325.00 | 40598.53 | |
| Uric acid | 835413.33 | 809483.29 | 1028277.20 | |
| Uridine | 15353770.00 | 14225481.00 | 14605566.67 | |
| Uridine 5^-diphosphate | 168511.82 | 72083.37 | 81831.49 | |
| Uridine 5^-monophosphate | 985018.44 | 737063.96 | 828504.52 | |
| Uridine diphosphate glucose | 2414026.00 | 2427627.14 | 2959053.33 | |
| Uridine diphosphate glucuronic acid | 63452.85 | 62142.98 | 93266.90 | |
| Uridine diphosphate-N-acetylglucosamine | 4290683.86 | 3439574.86 | 3900217.17 | |
| Uridine triphosphate | - | - | - | |
| Urocanic acid | 5343248.57 | 4267061.86 | 5282543.00 | |
| Xanthine | 19836728.57 | 24756327.14 | 20734113.33 |
Factors:
| F1 | Sample source:Brain | Genotype:C9orf72 | Treatment:2DG |
| F2 | Sample source:Brain | Genotype:C9orf72 | Treatment:Saline |
| F3 | Sample source:Brain | Genotype:WT | Treatment:Saline |
