Clustering data with hclust algorithm for High Insulin Combined With Essential Amino Acids Stimulates Skeletal Muscle Mitochondrial Protein Synthesis While Decreasing Insulin Sensitivity in Healthy Humans (Study ST000149)
ESI positive ion mode (Analysis AN000236)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| Methionine | ME696063 | 0.17 | 1.95 | 0.76 | 1.38 | 1.56 | 0.18 |
| Sarcosine | ME696050 | 0.74 | 2.06 | 0.88 | 0.79 | 0.66 | 0.87 |
| Homocystine | ME696065 | 0.60 | 1.08 | 1.57 | 0.82 | 0.54 | 0.93 |
| Tyrosine | ME696062 | 0.89 | 1.24 | 0.84 | 1.02 | 1.02 | 0.99 |
| Tryptophan | ME696067 | 0.77 | 1.26 | 0.90 | 1.14 | 1.10 | 0.82 |
| Valine | ME696080 | 0.73 | 1.25 | 0.88 | 1.19 | 1.18 | 0.77 |
| Cystathionine 1 | ME696059 | 0.82 | 1.22 | 1.00 | 1.11 | 1.03 | 0.82 |
| Histidine | ME696068 | 0.82 | 1.24 | 0.98 | 0.99 | 1.12 | 0.86 |
| Phenylalanine | ME696066 | 0.53 | 1.61 | 0.84 | 1.26 | 1.21 | 0.54 |
| Isoleucine | ME696081 | 0.64 | 1.33 | 0.84 | 1.32 | 1.21 | 0.66 |
| Leucine | ME696082 | 0.68 | 1.23 | 0.81 | 1.28 | 1.25 | 0.74 |
| Threonine | ME696075 | 0.68 | 1.25 | 0.84 | 1.21 | 1.29 | 0.72 |
| alpha-Aminoadipic-acid | ME696054 | 0.60 | 1.47 | 0.84 | 1.36 | 1.10 | 0.63 |
| Lysine | ME696079 | 0.69 | 1.41 | 0.92 | 1.21 | 1.07 | 0.71 |
| Citrulline | ME696051 | 0.95 | 1.43 | 0.90 | 0.77 | 0.81 | 1.14 |
| gamma-Amino-N-butyric-acid | ME696053 | 1.15 | 1.08 | 0.76 | 0.80 | 0.81 | 1.37 |
| Cystathionine 2 | ME696060 | 0.90 | 0.78 | 0.91 | 1.24 | 1.35 | 0.75 |
| beta-Alanine | ME696052 | 0.95 | 1.17 | 1.04 | 0.91 | 0.87 | 1.05 |
| Cystine | ME696061 | 1.04 | 0.98 | 1.03 | 0.92 | 0.93 | 1.10 |
| Phosphoethanolamine | ME696043 | 1.04 | 0.96 | 0.95 | 0.99 | 0.98 | 1.08 |
| 3-Methylhistidine | ME696044 | 0.90 | 1.04 | 1.05 | 1.00 | 1.04 | 0.98 |
| Glutamic acid | ME696074 | 0.99 | 1.07 | 1.03 | 1.04 | 0.92 | 0.96 |
| Ornithine | ME696078 | 1.15 | 0.79 | 0.73 | 1.19 | 0.99 | 1.16 |
| alpha-Amino-N-butyric-acid | ME696058 | 0.94 | 0.88 | 0.68 | 1.28 | 1.11 | 1.11 |
| Hydroxylysine 1 | ME696056 | 1.03 | 0.75 | 0.67 | 1.22 | 1.24 | 1.09 |
| Aspartic Acid | ME696049 | 1.02 | 0.92 | 0.81 | 0.96 | 0.98 | 1.31 |
| 1-Methylhistidine | ME696042 | 1.14 | 0.84 | 0.79 | 1.01 | 1.17 | 1.00 |
| Asparagine | ME696045 | 1.02 | 0.84 | 0.82 | 1.12 | 1.17 | 1.04 |
| Hydroxylysine 2 | ME696057 | 1.04 | 0.85 | 0.75 | 1.15 | 1.14 | 1.07 |
| Glycine | ME696073 | 1.13 | 0.88 | 0.82 | 1.02 | 1.04 | 1.11 |
| Proline | ME696077 | 1.09 | 0.94 | 0.86 | 1.02 | 0.97 | 1.13 |
| Arginine | ME696069 | 1.00 | 0.91 | 0.85 | 1.03 | 1.07 | 1.14 |
| Serine | ME696071 | 1.06 | 0.86 | 0.80 | 1.08 | 1.02 | 1.18 |
| Alanine | ME696076 | 0.91 | 1.04 | 0.83 | 1.09 | 1.13 | 1.00 |
| beta-Aminoisobutyric-acid | ME696055 | 0.96 | 1.01 | 0.85 | 1.10 | 1.12 | 0.97 |
| Ethanolamine | ME696048 | 1.00 | 0.95 | 0.87 | 0.99 | 1.13 | 1.05 |
| Hydroxyproline | ME696041 | 1.05 | 0.93 | 0.90 | 0.99 | 1.09 | 1.03 |
| Glutamine | ME696072 | 0.99 | 1.00 | 0.87 | 1.05 | 1.03 | 1.05 |
| Taurine | ME696070 | 1.01 | 0.94 | 0.82 | 1.11 | 1.06 | 1.05 |
Factors:
| F1 | Sample Group:High Insulin |
| F2 | Sample Group:High Insulin + EAA |
| F3 | Sample Group:High Insulin+Saline |
| F4 | Sample Group:Low Ins +EAA |
| F5 | Sample Group:Low Ins+ Saline |
| F6 | Sample Group:Low Insulin |
