Clustering data with hclust algorithm for Glycolysis/TCA/Nucleotide_Wt_KO_TimeCourse_LPS (Study ST000209)
ESI negative ion mode (Analysis AN000311)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phosphoenolpyruvate | ME698013 | 0.03 | 0.05 | 1.08 | 1.43 | 1.64 | 1.78 | 2.32 | 2.44 | 0.07 | 0.21 | 0.36 | 0.58 |
| Sucrose | ME698014 | 0.10 | 0.12 | 1.01 | 1.49 | 1.47 | 1.79 | 2.19 | 2.33 | 0.12 | 0.27 | 0.41 | 0.70 |
| Acetyl-CoA | ME698016 | 0.51 | 0.45 | 0.94 | 1.25 | 1.21 | 1.55 | 2.05 | 1.43 | 0.50 | 0.70 | 0.58 | 0.82 |
| Sedoheptulose 7-phosphate | ME698021 | 0.34 | 0.41 | 0.69 | 1.64 | 1.03 | 1.74 | 1.33 | 2.01 | 0.42 | 0.92 | 0.47 | 1.00 |
| Ribose-5-phosphate or xylulose 5-phosphate | ME698020 | 0.42 | 0.37 | 1.06 | 0.72 | 2.24 | 0.75 | 1.52 | 1.03 | 0.95 | 0.57 | 1.63 | 0.74 |
| AMP | ME698025 | 1.32 | 0.95 | 0.71 | 0.74 | 1.09 | 0.51 | 0.81 | 0.41 | 1.69 | 0.92 | 1.88 | 0.97 |
| 2 or 3-phosphoglycerate_2PG/3PG | ME698015 | 0.24 | 0.23 | 0.91 | 1.32 | 1.16 | 1.10 | 1.13 | 1.73 | 0.65 | 1.33 | 0.82 | 1.38 |
| Fructose 1,6-bisphosphate | ME698009 | 0.65 | 0.62 | 0.94 | 1.38 | 0.97 | 0.98 | 1.08 | 1.23 | 0.80 | 1.34 | 0.82 | 1.21 |
| Glucose 6-phosphate or fructose-6-phosphate | ME698019 | 0.52 | 0.58 | 0.75 | 1.23 | 1.08 | 1.15 | 1.25 | 1.46 | 0.77 | 1.21 | 0.77 | 1.26 |
| Nicotinamide Adenine Dinucleotide reduced | ME698012 | 0.51 | 0.62 | 0.98 | 1.08 | 0.74 | 0.83 | 0.88 | 0.93 | 0.81 | 1.96 | 0.94 | 1.71 |
| ADP | ME698026 | 0.85 | 0.81 | 1.00 | 1.19 | 1.19 | 0.84 | 1.19 | 0.84 | 0.86 | 1.19 | 0.93 | 1.10 |
| nicotinamide adenine dinucleotide phosphate oxidized | ME698023 | 1.03 | 0.93 | 1.01 | 1.03 | 1.04 | 0.88 | 1.13 | 0.86 | 0.95 | 1.06 | 1.01 | 1.07 |
| nicotinamide adenine dinucleotide phosphate reduced | ME698024 | 1.10 | 1.04 | 1.02 | 0.95 | 0.81 | 0.86 | 1.14 | 0.73 | 0.92 | 1.26 | 0.98 | 1.20 |
| ATP | ME698027 | 0.97 | 1.14 | 0.96 | 1.05 | 0.88 | 0.93 | 1.19 | 0.91 | 0.76 | 1.20 | 0.80 | 1.20 |
| flavin adenine dinucleotide | ME698022 | 0.92 | 1.17 | 1.01 | 1.01 | 1.07 | 0.87 | 1.15 | 0.75 | 0.93 | 1.16 | 0.81 | 1.13 |
| Nicotinamide Adenine Dinucleotide oxidized | ME698011 | 0.92 | 0.97 | 1.04 | 1.02 | 0.77 | 0.94 | 0.87 | 0.81 | 0.95 | 1.83 | 0.88 | 1.01 |
| Citrate or Isocitrate | ME698017 | 0.91 | 0.71 | 1.13 | 0.91 | 1.13 | 0.77 | 1.07 | 0.94 | 0.96 | 1.50 | 0.93 | 1.03 |
| Malate | ME698010 | 0.75 | 0.68 | 1.06 | 0.84 | 1.11 | 0.73 | 1.06 | 0.66 | 1.11 | 1.79 | 1.14 | 1.07 |
Factors:
| F1 | time course:0h | Cell type:KO macrophage | Treatment:untreated |
| F2 | time course:0h | Cell type:Wt macrophage | Treatment:untreated |
| F3 | time course:12h | Cell type:KO macrophage | Treatment:LPS |
| F4 | time course:12h | Cell type:Wt macrophage | Treatment:LPS |
| F5 | time course:18h | Cell type:KO macrophage | Treatment:LPS |
| F6 | time course:18h | Cell type:Wt macrophage | Treatment:LPS |
| F7 | time course:24h | Cell type:KO macrophage | Treatment:LPS |
| F8 | time course:24h | Cell type:Wt macrophage | Treatment:LPS |
| F9 | time course:3h | Cell type:KO macrophage | Treatment:LPS |
| F10 | time course:3h | Cell type:Wt macrophage | Treatment:LPS |
| F11 | time course:6h | Cell type:KO macrophage | Treatment:LPS |
| F12 | time course:6h | Cell type:Wt macrophage | Treatment:LPS |
