Clustering data with hclust algorithm for Murine gut bile acid analysis (Study ST000212)
ESI negative ion mode (Analysis AN000314)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Taurocholic acid | ME698070 | 1.55 | 0.08 | 1.14 | 0.08 | NA | NA | NA | NA | NA | 10.29 | 1.03 | 0.08 |
| b-Muricholic acid | ME698059 | 0.00 | 0.32 | 0.00 | 0.29 | 0.01 | 0.45 | 0.01 | 4.16 | 0.01 | 6.07 | 0.00 | 0.47 |
| Cholic acid | ME698060 | 0.05 | 0.04 | 0.03 | 0.08 | 0.23 | 0.66 | 0.46 | 4.00 | 0.33 | 5.80 | 0.04 | 0.13 |
| ?a-Muricholic acid | ME698058 | 0.01 | 0.12 | 0.00 | 0.15 | 0.02 | 0.11 | 0.02 | 3.29 | 0.02 | 6.67 | 0.00 | 0.73 |
| g-Muricholic acid (hyocholic acid) | ME698067 | 0.01 | 0.12 | 0.01 | 0.20 | 0.01 | 0.11 | 0.03 | 3.94 | 0.01 | 7.29 | 0.01 | 0.27 |
| Chenodeoxycholic acid | ME698061 | 0.05 | NA | 0.03 | NA | 0.23 | 0.87 | 0.26 | 3.06 | 0.19 | 4.22 | 0.06 | NA |
| w-Muricholic acid | ME698075 | NA | 0.59 | NA | 0.54 | 0.00 | 0.20 | 0.02 | 2.47 | 0.01 | 4.17 | NA | 0.99 |
| Glycodeoxycholic acid | ME698065 | 0.44 | 0.56 | 0.56 | 0.58 | 0.44 | 2.23 | 0.29 | 1.97 | 0.37 | 2.73 | 0.51 | 1.33 |
| Taurolithocolic acid | ME698074 | 0.32 | 0.42 | 0.39 | 0.44 | 0.73 | 2.38 | 0.52 | 2.53 | 0.74 | 2.08 | 0.38 | 1.07 |
| Glychocholic acid | ME698063 | 0.02 | 0.02 | 0.02 | 0.02 | 0.49 | 2.70 | 0.37 | 4.01 | 0.68 | 3.59 | 0.02 | 0.05 |
| Taurodeoxycholic acid | ME698072 | 0.01 | 0.09 | 0.02 | 0.16 | 0.01 | 4.45 | 0.01 | 3.00 | 0.01 | 3.94 | 0.02 | 0.29 |
| Taurochenodeoxycholic acid | ME698071 | 0.05 | 0.01 | 0.04 | 0.01 | 2.63 | 1.66 | 2.06 | 1.35 | 2.92 | 1.21 | 0.05 | 0.02 |
| Glycochenodeoxycholic acid | ME698064 | 0.50 | 0.52 | 0.61 | 0.52 | 1.27 | 1.58 | 0.98 | 1.24 | 1.48 | 1.36 | 0.58 | 1.36 |
| GLYCO-HYODEOXYCHOLIC ACID/GLYCOURSODEOXYCHOLIC ACID | ME698076 | 0.35 | 0.36 | 0.43 | 0.36 | 1.94 | 1.37 | 1.72 | 0.83 | 2.41 | 0.88 | 0.41 | 0.94 |
| Tauroursodeoxycholic acid/Tauro-hyodeoxycholic acid | ME698073 | 1.70 | 0.25 | 1.36 | 0.54 | NA | NA | NA | NA | NA | NA | 1.37 | 0.50 |
| Lithocholic acid | ME698069 | 0.05 | 2.78 | 0.07 | 2.85 | 0.06 | 0.14 | 0.04 | 0.12 | 0.05 | 0.08 | 0.06 | 5.71 |
| Glycolithocholic acid | ME698066 | 0.48 | 0.97 | 0.74 | 1.51 | 0.87 | 1.25 | 0.50 | 1.27 | 0.97 | 0.68 | 0.60 | 2.32 |
| Deoxycholic acid | ME698062 | NA | 1.18 | NA | 1.43 | NA | 0.14 | NA | 0.30 | NA | 0.44 | NA | 2.54 |
| Hyodeoxycholic acid | ME698068 | NA | 1.94 | 0.00 | 1.73 | 0.02 | 0.31 | 0.02 | 1.10 | 0.02 | 1.23 | 0.00 | 3.30 |
Factors:
| F1 | GI tract location:cecum | treatment:cefoperazone |
| F2 | GI tract location:cecum | treatment:vehicle |
| F3 | GI tract location:colon | treatment:cefoperazone |
| F4 | GI tract location:colon | treatment:vehicle |
| F5 | GI tract location:duodenum | treatment:cefoperazone |
| F6 | GI tract location:duodenum | treatment:vehicle |
| F7 | GI tract location:ileum | treatment:cefoperazone |
| F8 | GI tract location:ileum | treatment:vehicle |
| F9 | GI tract location:jejunum | treatment:cefoperazone |
| F10 | GI tract location:jejunum | treatment:vehicle |
| F11 | GI tract location:stool | treatment:cefoperazone |
| F12 | GI tract location:stool | treatment:vehicle |
