Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Targeting CRBN to alter CD8 T cell metabolism (Study ST000307)

NEGATIVE ION MODE (Analysis AN000487)

Metabolite	Structure	F1	F2	F3	F4	F5	F6
ALPHA-HYDROXYISOBUTYRIC ACID	ME108618	3.36	0.47	0.53	0.49	0.54	0.62
SUCCINATE	ME108652	3.18	0.95	0.28	0.51	0.42	0.65
3-(2-HYDROXYPHENYL)PROPANOATE	ME108607	4.93	0.34	0.25	0.08	0.30	0.10
HOMOVANILLATE	ME108634	4.52	0.71	0.32	0.17	0.21	0.08
MEVALOLACTONE	ME108642	3.79	0.63	0.85	0.27	0.18	0.28
NICOTINATE	ME108648	4.28	0.29	0.13	0.25	0.08	0.97
N-ACETYL-DL-GLUTAMIC ACID	ME108643	3.92	0.61	0.29	0.28	0.24	0.66
N-ACETYL-L-LEUCINE	ME108647	4.45	0.33	0.30	0.27	0.30	0.36
3-METHYL-2-OXOVALERIC ACID	ME108609	4.13	0.35	0.46	0.22	0.38	0.47
4-METHYL-2-OXO-PENTANOIC ACID	ME108613	4.13	0.33	0.35	0.37	0.36	0.47
C12H22O11-DISACCHARIDE-(6C/6C; GLC-GLC/GLC-FRC/GAL-GLC)	ME108620	0.03	1.96	1.16	0.71	0.22	1.92
GUANOSINE 5^-MONOPHOSPHATE	ME108632	0.55	1.42	NA	0.10	0.31	1.98
GLUCONIC ACID	ME108627	0.30	1.92	0.08	0.96	0.25	2.48
HYPOXANTHINE	ME108635	0.15	1.56	0.27	1.03	0.74	2.26
2-HYDROXYPHENYLACETIC ACID	ME108606	0.95	0.46	1.15	0.36	0.23	2.86
THYMIDINE 5^-MONOPHOSPHATE	ME108655	0.02	0.23	0.00	0.00	0.10	3.31
O-ACETYL-L-SERINE	ME108650	1.17	0.67	0.27	0.36	0.30	3.23
L-PHENYLALANINE	ME108639	0.77	1.07	0.28	0.33	0.25	3.30
THREONINE/HOMOSERINE	ME108654	0.48	0.96	0.50	0.62	0.38	3.06
XANTHINE	ME108660	0.60	1.07	0.28	0.59	0.49	2.96
ALDOPENTOSE	ME108616	0.14	1.33	0.06	0.95	0.12	3.41
C6H12O6-HEXOSE/KETOSE/INOSITOL	ME108621	0.05	0.95	0.09	0.93	0.07	3.92
L-METHIONINE	ME108638	0.60	0.66	0.17	0.09	0.25	4.22
N-METHYL-D-ASPARTIC ACID	ME108649	0.47	0.70	0.22	0.62	0.29	3.70
ISOCITRIC ACID	ME108636	1.02	2.20	0.32	2.13	0.18	0.14
N-ACETYL-L-ASPARTIC ACID	ME108646	1.19	2.85	0.19	0.93	0.38	0.46
3-SULFINO-L-ALANINE	ME108610	0.03	3.42	0.27	1.16	0.42	0.70
CREATINE	ME108623	0.02	2.47	0.29	1.21	1.19	0.83
GUANINE	ME108631	0.18	2.59	0.33	0.91	0.92	1.07
Disaccharide (6C/6C)	ME108625	0.16	2.29	1.12	0.96	0.34	1.13
ALLANTOIN	ME108617	0.37	2.22	0.61	1.39	0.47	0.75
hexose alcohol	ME108633	0.20	2.63	0.60	1.40	0.31	0.87
MALONIC ACID	ME108641	0.23	2.55	0.56	1.15	0.37	1.15
CYTIDINE	ME108624	2.47	0.64	0.21	0.28	0.44	1.97
URACIL	ME108656	2.81	0.40	0.31	0.21	0.45	1.83
CITRAMALATE	ME108622	2.36	1.41	0.21	0.60	0.41	1.02
URIDINE	ME108658	2.57	0.99	0.24	0.31	0.47	1.41
4-PYRIDOXATE	ME108614	2.50	0.49	2.00	0.36	0.27	0.37
2^,4^-DIHYDROXYACETOPHENONE	ME108605	1.41	0.65	1.54	0.67	0.62	1.11
4-GUANIDINOBUTANOATE	ME108612	1.46	1.42	1.44	0.77	0.38	0.52
3-HYDROXYPHENYLACETATE	ME108608	2.22	1.05	1.45	0.50	0.37	0.42
AZELAIC ACID	ME108619	1.83	0.93	1.69	0.48	0.55	0.51
L-GLUTAMINE	ME108637	0.58	1.61	0.65	0.74	0.57	1.85
GLUTARATE	ME108628	1.09	1.49	0.52	0.72	0.67	1.51
L-TYROSINE	ME108640	1.43	1.64	0.43	0.65	0.37	1.48
(R)-MALATE	ME108604	1.64	1.88	0.13	1.06	0.36	0.93
URATE	ME108657	0.76	2.01	0.69	0.92	0.67	0.95
N-ACETYL-DL-SERINE	ME108644	1.23	1.76	0.78	0.83	0.66	0.74
UROCANATE	ME108659	1.38	1.77	0.79	0.73	0.74	0.60
GLYCOLATE	ME108630	0.57	0.74	1.59	0.82	0.52	1.75
Salicylic Acid-d4	ME108651	0.99	0.97	0.90	0.98	1.03	1.13
Succinic Acid-d4	ME108653	0.89	1.03	0.97	1.08	0.99	1.04
ADENINE	ME108615	0.96	0.74	0.94	0.62	0.87	1.88
GLYCERALDEHYDE/LACTATE	ME108629	0.87	0.96	0.99	0.79	0.86	1.54
N-ACETYLGLYCINE	ME108645	1.71	1.00	0.46	0.74	1.36	0.72
4-COUMARATE	ME108611	1.83	0.71	0.79	0.73	0.70	1.24
ETHYLMALONIC ACID	ME108626	1.65	1.10	0.47	0.72	0.54	1.52

Factors:

F1	Strain:CRBN -/- \| Treatment:anti-CD3 & anti-CD28 stimulation
F2	Strain:CRBN +/+ \| Treatment:anti-CD3 & anti-CD28 stimulation
F3	Strain:CRBN -/- \| Treatment:anti-CD3 stimulation
F4	Strain:CRBN +/+ \| Treatment:anti-CD3 stimulation
F5	Strain:CRBN -/- \| Treatment:unstimulated
F6	Strain:CRBN +/+ \| Treatment:unstimulated

Data matrix