Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease (Study ST000352)

UPLC POSITIVE ION MODE (Analysis AN000572)

Metabolite	Structure	F1	F2	F3	F4
adenosine	ME119962	0.21	0.21	0.66	2.91
N-delta-acetylornithine*	ME120016	0.47	0.40	1.37	1.76
threonine	ME120037	1.40	1.29	0.79	0.53
spermine	ME120034	1.39	1.55	0.52	0.54
ophthalmate	ME120019	1.50	1.40	0.58	0.52
pro-hydroxy-pro	ME120025	1.44	1.38	0.59	0.46
hydroxybutyrylcarnitine*	ME120002	1.28	1.24	1.04	0.43
guanosine 5^- monophosphate (5^-GMP)	ME120000	1.13	1.43	0.63	0.76
spermidine	ME120033	1.19	1.22	0.80	0.79
proline	ME120026	1.13	1.16	0.89	0.82
5-aminovalerate	ME119959	1.20	1.12	0.85	0.84
5-methylthioadenosine (MTA)	ME119960	1.19	1.17	0.84	0.81
cytidine-5^-diphosphoethanolamine	ME119982	1.11	1.31	0.80	0.78
guanosine	ME119999	1.18	1.26	0.70	0.87
cytidine 5^-monophosphate (5^-CMP)	ME119981	1.08	1.21	0.84	0.87
cytidine	ME119979	1.15	1.22	0.78	0.85
pipecolate	ME120024	1.12	1.24	0.77	0.87
choline phosphate	ME119973	1.29	1.23	0.72	0.76
gamma-glutamylthreonine*	ME119990	1.30	1.10	0.80	0.67
corticosterone	ME119975	0.47	0.50	1.42	0.96
propionylcarnitine	ME120027	0.70	0.70	1.46	1.14
serylleucine	ME120031	0.78	0.79	1.43	1.06
beta-hydroxyisovaleroylcarnitine	ME119967	0.75	0.79	1.33	1.13
carnitine	ME119970	0.77	0.80	1.34	1.10
stachydrine	ME120035	0.48	0.56	1.17	1.37
glycerophosphorylcholine (GPC)	ME119997	0.65	0.63	1.16	1.57
pyroglutamine*	ME120029	0.68	0.67	1.13	1.51
2-linoleoylglycerophosphoethanolamine*	ME119952	0.80	1.04	0.78	1.33
1-stearoylglycerophosphocholine (18:0)	ME119945	0.75	0.79	1.00	1.46
2-palmitoylglycerophosphocholine*	ME119955	0.88	0.71	0.98	1.43
1-oleoylglycerophosphocholine (18:1)	ME119942	0.87	0.76	0.95	1.43
1-palmitoylglycerophosphocholine (16:0)	ME119944	0.88	0.78	0.93	1.40
1-stearoylglycerophosphoethanolamine	ME119946	0.85	0.79	1.05	1.32
2-palmitoylglycerophosphoethanolamine*	ME119956	0.87	0.73	1.01	1.34
2-arachidonoylglycerophosphoethanolamine*	ME119948	0.84	0.82	0.96	1.38
2-docosahexaenoylglycerophosphoethanolamine*	ME119950	0.81	0.83	0.99	1.37
2-docosahexaenoylglycerophosphocholine*	ME119949	0.77	0.82	1.05	1.37
2-oleoylglycerophosphocholine*	ME119954	0.81	0.86	1.03	1.35
1-palmitoleoylglycerophosphocholine (16:1)*	ME119943	1.16	0.88	1.41	0.87
isobutyrylcarnitine	ME120003	1.03	0.95	1.28	0.74
isovalerylcarnitine	ME120005	0.87	0.85	1.22	1.06
succinylcarnitine	ME120036	0.84	0.82	1.20	1.02
3-dehydrocarnitine*	ME119957	0.86	0.91	1.26	0.98
acetylcarnitine	ME119961	0.94	0.91	1.23	0.93
butyrylcarnitine	ME119969	0.91	0.91	1.30	0.89
ergothioneine	ME119985	1.07	0.85	1.08	1.01
glycylleucine	ME119998	1.01	0.82	1.14	1.03
riboflavin (Vitamin B2)	ME120030	0.99	0.89	1.12	0.99
N6-methyladenosine	ME120011	0.93	1.01	1.09	0.97
serylphenyalanine	ME120032	0.87	1.01	1.09	1.01
arginine	ME119965	0.99	0.95	1.04	1.03
creatine	ME119976	0.99	0.99	1.02	1.00
xanthine	ME120041	0.99	0.98	1.04	0.99
glutathione, oxidized (GSSG)	ME119995	1.04	1.00	0.96	1.01
glutamine	ME119994	1.01	1.01	0.99	0.98
methionine	ME120008	1.03	0.99	1.01	0.97
xanthosine	ME120042	0.89	0.98	1.04	1.09
adenosine 5^-monophosphate (AMP)	ME119964	0.94	0.96	1.04	1.06
glutathione, reduced (GSH)	ME119996	0.92	0.96	1.08	1.04
palmitoylcarnitine	ME120020	0.98	0.91	1.03	1.06
N6-acetyllysine	ME120010	0.98	0.95	1.00	1.07
creatinine	ME119977	0.97	0.98	0.98	1.07
nicotinamide	ME120017	0.97	0.98	1.01	1.05
cysteine-glutathione disulfide	ME119978	0.87	0.77	1.19	1.17
gamma-glutamylglutamate	ME119986	0.80	0.77	1.19	1.24
gamma-glutamylglutamine	ME119987	0.90	0.93	1.06	1.11
argininosuccinate	ME119966	0.93	0.90	1.09	1.08
choline	ME119972	0.89	0.90	1.11	1.10
glutamate	ME119992	0.91	0.89	1.08	1.13
1-methylimidazoleacetate	ME119941	0.87	0.86	1.12	1.16
N-acetylglutamine	ME120014	0.83	0.86	1.13	1.18
homocitrulline	ME120001	0.76	0.93	1.11	1.20
N-acetylglutamate	ME120013	0.83	0.94	1.10	1.14
2-arachidonoylglycerophosphocholine*	ME119947	0.98	0.77	1.04	1.21
2-docosapentaenoylglycerophosphoethanolamine*	ME119951	0.92	0.87	0.99	1.22
nicotinamide adenine dinucleotide (NAD+)	ME120018	0.91	0.89	0.99	1.13
phosphopantetheine	ME120023	0.99	1.03	0.95	1.04
deoxycarnitine	ME119983	1.00	1.03	0.87	1.09
pyridoxal	ME120028	1.03	1.00	0.91	1.07
citrulline	ME119974	1.11	1.07	0.83	0.99
betaine	ME119968	1.06	1.04	0.79	1.10
N1-methyladenosine	ME120009	1.02	1.14	0.75	1.05
4-guanidinobutanoate	ME119958	0.99	1.10	0.83	1.08
glutamate, gamma-methyl ester	ME119993	1.03	1.10	0.82	1.04
dimethylarginine (SDMA + ADMA)	ME119984	0.92	1.17	1.03	0.85
valine	ME120040	1.19	1.08	0.96	0.76
leucine	ME120006	1.05	0.99	1.06	0.90
phenylalanine	ME120022	1.04	0.97	1.10	0.89
2-methylbutyrylcarnitine (C5)	ME119953	1.08	0.94	1.13	0.84
gamma-glutamylphenylalanine	ME119989	1.08	0.98	1.10	0.85
adenosine 2^-monophosphate (2^-AMP)	ME119963	1.04	1.05	1.04	0.87
isoleucine	ME120004	1.13	1.04	0.99	0.84
gamma-glutamylleucine	ME119988	1.12	1.04	1.05	0.79
gamma-glutamyltyrosine	ME119991	1.10	1.02	1.05	0.84
tryptophan	ME120038	1.09	1.03	1.04	0.84
cytidine 5^-diphosphocholine	ME119980	1.17	0.96	0.91	0.96
C-glycosyltryptophan*	ME119971	1.02	1.09	0.92	0.97
N-acetylneuraminate	ME120015	1.01	1.06	0.94	0.98
pantothenate	ME120021	1.10	1.10	0.95	0.85
tyrosine	ME120039	1.11	1.04	0.95	0.90
lysine	ME120007	1.06	1.08	0.93	0.92
N-acetyl-aspartyl-glutamate (NAAG)	ME120012	1.08	1.06	0.95	0.91

Factors:

F1	age:P15 \| genotype:Twitcher
F2	age:P15 \| genotype:Wild Type
F3	age:P22 \| genotype:Twitcher
F4	age:P22 \| genotype:Wild Type

Data matrix