Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures (Study ST000379)

GC POSITIVE ION MODE (Analysis AN000613)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13
sorbitol	ME132730	0.07	0.09	0.11	0.08	0.31	0.25	0.28	0.24	0.11	0.11	0.07	0.08	11.21
ribitol	ME132735	0.77	0.71	0.77	0.66	0.72	0.75	0.63	0.72	0.58	0.67	0.56	0.79	4.67
tagatose	ME132725	0.37	0.33	0.34	0.39	0.42	0.34	0.43	0.37	0.52	0.36	0.42	0.38	8.32
gluconic acid lactone	ME132788	0.36	0.33	0.44	0.28	1.03	1.15	0.68	1.23	0.43	0.27	0.21	0.30	6.29
UDP GlcNAc	ME132717	0.42	0.41	0.65	0.56	0.61	0.47	0.77	0.55	0.44	0.39	0.30	0.50	6.92
putrescine	ME132738	0.35	0.64	0.09	2.84	0.30	0.29	0.07	3.38	0.38	0.39	0.17	4.01	0.10
cholesterol	ME132803	1.72	3.78	0.12	3.61	0.11	0.09	0.11	0.10	0.11	0.10	1.48	1.58	0.09
fructose	ME132793	0.15	0.16	0.20	0.09	3.65	2.78	2.21	2.67	0.24	0.12	0.10	0.12	0.50
talose	ME132724	2.23	0.94	4.65	1.09	0.08	0.96	0.44	0.86	1.02	0.35	0.10	0.23	0.04
urea	ME132715	1.51	0.84	0.84	0.55	1.07	0.92	0.04	2.13	2.07	1.09	0.05	1.46	0.43
mannose-6-phosphate NIST	ME132761	2.26	1.40	1.18	2.05	0.69	0.99	0.40	0.92	1.00	0.49	0.28	0.52	0.81
aspartic acid	ME132810	0.70	1.63	0.37	1.14	0.65	2.03	0.40	1.73	0.49	1.56	0.31	1.42	0.57
1-monostearin	ME132824	1.06	0.74	0.65	0.85	0.85	0.89	0.75	0.82	0.86	2.83	0.95	0.92	0.84
alanine	ME132814	0.53	0.69	1.80	1.13	0.51	0.68	1.94	1.24	0.46	0.68	1.57	1.26	0.52
glucose	ME132787	1.66	1.30	2.29	0.77	1.05	0.59	0.55	0.54	1.79	0.46	0.47	0.46	1.06
mannose	ME132762	1.05	0.86	1.50	0.40	1.59	1.08	1.22	1.12	1.68	0.17	0.26	0.17	1.89
fructose-6-phosphate	ME132792	1.66	0.83	0.78	0.98	1.07	1.04	1.90	1.06	1.53	0.42	0.20	0.48	1.06
galactose-6-phosphate	ME132790	1.31	0.73	1.47	1.05	1.49	1.08	1.19	0.83	1.96	0.54	0.29	0.46	0.60
glucose-6-phosphate	ME132786	1.46	0.90	1.09	1.02	1.55	1.30	1.11	1.25	1.63	0.53	0.21	0.52	0.43
pyrophosphate	ME132736	1.00	1.00	0.82	1.00	0.91	0.92	0.91	1.06	0.85	0.77	0.62	1.21	1.92
isothreonic acid	ME132770	1.06	0.94	0.83	0.99	1.14	0.96	0.97	0.86	0.64	0.72	0.44	1.08	2.37
ribulose-5-phosphate	ME132732	0.91	0.90	0.87	0.88	0.94	0.98	0.66	0.99	0.83	0.90	0.65	1.03	2.47
behenic acid	ME132809	1.00	0.57	0.56	0.84	0.98	0.77	0.88	1.19	1.07	0.87	1.01	0.83	2.42
erythritol	ME132794	1.18	0.74	0.83	0.88	1.25	0.88	0.95	1.00	1.09	0.71	0.80	0.85	1.82
hexuronic acid	ME132778	1.05	0.93	0.96	0.93	0.98	0.79	0.85	0.73	1.02	0.84	1.00	0.87	2.04
inosine	ME132774	0.98	0.80	0.93	0.91	0.94	0.85	0.89	0.90	0.88	0.75	0.92	0.80	2.46
N-acetyl-D-mannosamine	ME132754	1.17	0.73	0.73	0.83	1.09	0.88	0.91	0.90	1.17	0.74	0.75	0.77	2.32
mannitol	ME132763	0.82	0.67	1.14	0.70	0.95	1.39	0.65	0.46	0.88	0.71	0.75	0.76	3.13
cysteine	ME132800	0.86	0.59	0.80	0.83	0.93	0.79	0.62	0.80	1.09	0.91	0.79	0.78	3.22
uracil	ME132716	1.12	0.87	0.64	0.96	0.74	0.83	0.92	0.52	0.83	0.68	0.97	0.75	3.18
taurine	ME132723	0.66	0.62	0.85	0.82	0.84	1.07	1.95	0.67	1.12	0.84	2.19	0.61	0.75
2-hydroxyglutaric acid	ME132822	0.49	0.57	0.94	0.74	1.38	0.57	1.61	0.79	1.70	1.23	1.53	0.95	0.50
5^-deoxy-5^-methylthioadenosine	ME132818	1.07	0.85	1.46	0.59	0.94	0.77	1.26	0.44	1.40	1.07	2.11	0.49	0.55
adenine	ME132816	1.17	0.78	1.24	0.62	1.14	0.80	1.17	0.58	1.43	1.09	1.55	0.48	0.94
alpha ketoglutaric acid	ME132813	0.85	0.74	1.37	1.62	0.71	0.47	1.17	1.06	0.52	1.00	1.11	2.06	0.30
fumaric acid	ME132791	0.91	1.47	0.71	1.64	0.59	1.17	0.65	1.44	0.54	1.17	0.59	1.78	0.34
malic acid	ME132764	0.91	1.48	0.65	1.65	0.53	1.17	0.62	1.47	0.48	1.21	0.61	1.98	0.25
succinic acid	ME132727	0.52	0.97	0.77	1.42	1.06	1.04	0.86	1.58	0.73	0.96	0.76	1.90	0.42
phosphogluconic acid	ME132743	0.92	1.20	0.95	1.45	0.72	1.06	0.72	1.23	1.12	0.89	0.65	1.46	0.63
pyrazine 2,5-dihydroxy NIST	ME132737	0.76	0.94	0.69	1.39	1.03	0.90	0.80	1.19	0.99	1.29	0.83	1.53	0.66
tyrosine	ME132718	0.33	1.44	0.99	0.70	1.20	1.32	1.17	1.57	0.80	1.17	0.39	0.69	1.22
2-aminoadipic acid	ME132823	0.52	0.85	0.42	1.33	1.56	1.13	0.95	1.67	1.68	1.27	0.33	0.92	0.38
lauric acid	ME132767	0.59	0.59	1.11	1.38	1.53	1.06	0.88	1.06	1.11	1.31	0.51	0.94	0.93
elaidic acid	ME132795	0.39	0.80	0.80	1.09	0.68	0.72	1.01	2.28	1.08	0.91	1.53	0.72	0.99
oleic acid	ME132751	0.87	0.91	0.83	0.72	0.99	0.66	1.03	1.90	1.30	1.13	0.96	0.87	0.83
triethanolamine	ME132720	0.93	0.80	0.82	0.85	1.00	0.86	0.81	2.10	1.00	0.97	1.09	0.86	0.90
beta-alanine	ME132807	1.33	1.37	0.54	0.87	1.18	1.46	0.51	0.76	1.15	1.41	0.32	0.89	1.21
glutamine	ME132784	1.19	1.34	0.27	0.93	1.21	1.41	0.17	1.14	1.47	1.25	0.18	1.05	1.40
gluconic acid	ME132789	0.98	0.98	0.75	1.02	1.13	0.82	0.61	1.31	0.95	1.20	0.64	1.13	1.47
methanolphosphate	ME132760	1.27	1.15	0.58	1.11	1.24	1.02	0.60	1.15	1.29	1.27	0.54	1.33	0.43
pantothenic acid	ME132747	1.04	1.22	0.38	1.17	0.93	1.28	0.49	1.25	0.92	1.54	0.33	1.45	1.00
cytidine-5-monophosphate NIST	ME132799	1.39	0.88	0.64	0.37	1.32	1.04	0.73	0.70	1.33	1.09	1.52	1.08	0.90
adenosine	ME132815	1.28	1.17	0.65	1.01	0.58	1.25	1.00	0.70	1.02	0.73	1.68	0.90	1.02
asparagine	ME132811	1.35	0.86	0.69	0.83	0.75	0.71	0.95	0.74	0.90	1.26	1.75	1.02	1.20
3-phosphoglycerate	ME132819	0.90	1.20	1.35	1.37	0.88	0.81	0.71	0.82	0.92	1.28	1.33	1.19	0.25
lactic acid	ME132769	0.99	0.87	1.73	1.06	0.77	0.74	1.27	1.06	0.85	0.78	1.21	1.10	0.55
lathosterol NIST	ME132768	1.06	0.86	1.37	1.27	0.84	0.76	0.92	1.10	1.12	0.76	1.06	1.21	0.66
creatinine	ME132801	0.76	0.86	0.71	1.03	1.46	1.12	0.99	1.11	1.04	1.13	1.29	1.17	0.32
glycolic acid	ME132779	0.72	0.69	0.93	0.81	1.39	0.64	1.06	1.09	1.11	1.02	1.65	1.11	0.77
glycerol-alpha-phosphate	ME132782	1.78	1.12	1.03	1.17	1.27	0.90	0.90	0.79	0.96	0.92	0.39	0.88	0.89
glycerol-beta-phosphate	ME132781	1.48	0.85	1.04	1.05	1.25	0.79	0.95	0.79	1.19	0.97	0.83	0.74	1.07
ribose-5-phosphate	ME132733	1.35	0.94	1.14	1.13	1.23	0.82	0.87	0.89	1.06	0.75	0.72	1.03	1.07
6-deoxyglucitol NIST	ME132817	1.05	0.91	0.81	1.52	0.86	0.74	0.90	0.87	1.06	0.83	1.20	1.30	0.96
sucrose	ME132726	1.39	1.28	0.74	0.84	0.74	0.97	0.68	0.92	1.19	0.84	1.06	1.48	0.89
ribose	ME132734	0.92	0.92	0.64	1.11	0.87	1.59	1.09	1.19	0.93	0.88	0.89	0.89	1.07
lysine	ME132765	0.76	1.00	1.22	0.68	0.97	0.89	1.03	1.21	1.29	0.74	1.00	0.79	1.42
arachidic acid	ME132812	0.63	0.62	0.96	0.99	1.04	0.94	1.11	1.35	1.21	1.29	0.88	0.94	1.02
ornithine	ME132750	0.67	0.74	1.30	0.96	1.17	0.95	1.12	1.28	0.98	1.00	0.97	0.94	0.92
salicylaldehyde	ME132731	1.06	1.22	0.90	0.63	1.33	1.19	1.25	0.82	0.80	0.99	1.34	0.90	0.58
methylhexadecanoic acid	ME132758	1.11	1.09	0.77	1.09	1.20	0.91	0.81	1.41	0.89	0.97	1.03	0.93	0.78
monopalmitin-1-glyceride	ME132757	1.05	1.01	0.87	1.08	0.99	1.07	0.86	1.25	1.15	1.02	0.96	1.00	0.68
myristic acid	ME132756	0.92	0.76	0.95	1.05	1.12	0.99	0.98	1.23	1.16	1.07	1.04	0.85	0.88
serine	ME132729	0.98	0.94	0.59	0.97	1.04	1.17	1.16	1.32	0.94	1.20	0.82	1.22	0.66
threonine	ME132722	0.97	1.04	0.75	1.02	1.06	1.18	0.88	1.15	0.94	1.15	0.78	1.08	1.02
trans-4-hydroxyproline	ME132721	1.02	0.99	0.75	1.07	1.09	1.04	0.91	1.10	0.98	1.01	0.81	1.27	0.96
N-acetylaspartic acid	ME132755	1.14	0.94	0.73	1.09	1.12	0.99	0.88	0.79	1.36	1.21	1.19	1.05	0.51
glutamic acid	ME132785	1.02	1.26	0.64	1.06	1.09	1.23	0.65	0.99	1.32	1.47	0.80	0.97	0.51
oxoproline	ME132749	1.26	1.16	0.68	1.06	1.04	1.08	0.64	0.92	1.31	1.27	0.78	1.00	0.81
benzoic acid	ME132808	1.06	1.07	0.98	1.13	1.04	1.08	1.00	0.90	1.14	1.07	0.79	0.89	0.88
isoleucine	ME132771	1.04	1.04	0.84	0.88	1.20	1.20	0.87	0.92	1.19	1.17	0.91	0.88	0.86
phenylalanine	ME132745	1.04	1.09	0.77	0.92	1.17	1.26	0.78	1.00	1.18	1.21	0.84	0.93	0.81
leucine	ME132766	1.07	1.02	0.78	0.90	1.29	1.24	0.79	0.86	1.20	1.26	0.77	0.88	0.93
methionine	ME132759	1.06	1.00	0.68	0.93	1.25	1.38	0.75	0.89	1.16	1.33	0.82	0.88	0.88
phosphoethanolamine	ME132744	0.88	0.78	0.99	0.85	1.07	1.00	0.67	1.17	0.88	1.13	1.27	1.05	1.26
pelargonic acid	ME132746	1.00	1.24	1.26	0.81	1.05	0.65	1.13	0.82	1.00	0.93	1.45	0.94	0.73
beta-sitosterol	ME132806	1.01	1.06	1.35	0.81	1.04	0.99	1.03	1.02	1.04	0.85	1.19	0.81	0.80
inositol-4-monophosphate	ME132772	0.90	0.92	1.33	0.86	0.91	0.87	1.21	0.88	1.02	0.87	1.56	0.71	0.95
idonic acid NIST	ME132775	0.96	1.00	1.00	0.92	1.13	0.91	1.12	0.83	0.92	1.36	1.35	0.92	0.58
glutathione	ME132783	1.01	0.94	1.10	1.14	0.72	0.91	1.04	0.84	1.06	1.34	1.14	0.96	0.82
proline	ME132740	1.01	0.87	1.17	1.11	0.99	0.92	1.10	0.88	0.87	1.10	0.97	1.11	0.89
glycine	ME132780	0.83	0.92	0.97	1.05	0.95	0.95	1.32	1.18	0.80	0.92	1.20	1.07	0.84
octadecanol	ME132752	1.05	0.78	0.85	0.87	1.00	0.92	1.42	0.96	1.03	1.02	1.07	0.99	1.04
dodecanol	ME132796	1.09	1.24	1.00	0.92	0.95	0.90	0.82	0.90	1.01	1.01	0.96	0.90	1.28
citramalic acid	ME132802	1.18	0.92	0.88	1.03	1.02	0.97	0.86	0.84	1.10	0.88	0.95	0.96	1.40
dehydroabietic acid	ME132798	1.04	0.87	0.83	1.07	1.04	0.96	0.94	0.86	1.11	0.96	1.17	0.84	1.29
1,2,4-benzenetriol	ME132825	0.93	1.13	1.05	0.77	0.75	1.14	0.94	0.87	1.22	1.23	1.15	0.94	0.89
dodecane	ME132797	0.80	1.03	1.06	0.99	1.04	0.96	1.13	0.77	1.15	0.96	1.39	0.85	0.87
homoserine	ME132777	1.06	0.78	1.03	0.83	1.03	0.88	1.19	0.68	1.31	1.11	1.35	0.75	0.99
inositol myo-	ME132773	0.86	0.84	1.14	0.70	1.11	1.02	1.14	0.83	1.29	1.10	1.37	0.72	0.85
3-aminoisobutyric acid	ME132820	1.06	0.92	1.04	0.93	1.24	0.84	1.04	0.92	0.88	0.95	1.36	0.93	0.88
phosphoric acid	ME132742	0.98	0.95	1.01	0.79	1.13	0.96	1.07	0.82	0.92	0.88	1.51	0.81	1.18
zymosterol	ME132713	1.32	0.99	0.82	0.98	1.01	0.88	1.03	1.06	1.15	0.89	1.05	0.86	0.97
propane-1,3-diol NIST	ME132739	0.92	0.99	0.91	0.89	1.11	0.88	0.96	0.87	1.26	1.11	1.04	1.03	1.01
valine	ME132714	1.02	0.81	0.93	0.91	1.13	1.17	0.94	0.91	1.18	1.18	1.01	0.94	0.88
N-methylalanine	ME132753	1.07	1.17	0.73	1.07	1.08	1.13	0.99	0.80	1.11	0.96	1.18	0.91	0.78
2-ketoisocaproic acid	ME132821	0.98	1.00	0.99	1.12	1.07	0.98	1.00	0.96	0.90	1.04	1.13	0.93	0.91
palmitic acid	ME132748	0.97	1.02	0.84	0.84	1.05	1.15	0.98	1.05	0.97	1.01	1.26	0.92	0.93
tryptophan	ME132719	0.91	0.96	0.92	0.90	1.09	1.10	0.97	1.01	1.04	1.12	1.08	0.94	0.95
butylamine NIST	ME132805	1.07	0.88	0.83	0.87	1.01	0.96	1.13	0.96	1.14	0.92	1.36	1.02	0.85
hydroxylamine	ME132776	1.09	0.96	0.74	0.98	1.09	1.03	0.95	0.92	1.18	1.00	1.20	0.81	1.05
stearic acid	ME132728	0.97	1.00	0.91	0.92	1.01	1.09	1.02	0.84	1.06	1.02	1.32	0.86	0.97
capric acid	ME132804	1.05	0.97	0.92	0.94	1.10	0.89	1.08	0.90	1.12	1.05	1.19	0.89	0.90
p-hydroquinone	ME132741	1.17	0.99	0.90	0.96	0.99	1.01	0.99	0.84	1.13	0.99	1.22	0.87	0.95

Factors:

F1	Treatment:10.5mM Glu \| Time:10min
F2	Treatment:10.5mM Glu \| Time:1hr
F3	Treatment:10.5mM Glu \| Time:24hr
F4	Treatment:10.5mM Glu \| Time:6hr
F5	Treatment:5.5mM Glu 5mM Fru \| Time:10min
F6	Treatment:5.5mM Glu 5mM Fru \| Time:1hr
F7	Treatment:5.5mM Glu 5mM Fru \| Time:24hr
F8	Treatment:5.5mM Glu 5mM Fru \| Time:6hr
F9	Treatment:5.5mM Glu \| Time:10min
F10	Treatment:5.5mM Glu \| Time:1hr
F11	Treatment:5.5mM Glu \| Time:24hr
F12	Treatment:5.5mM Glu \| Time:6hr
F13	Treatment:Glucosamine \| Time:10min

Data matrix