Summary of Study ST002989
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001861. The data can be accessed directly via it's Project DOI: 10.21228/M85B0W This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002989 |
| Study Title | Targeting NPM1 Epigenetically Promotes Post-infarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism |
| Study Summary | Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing. Metabolic adaptation orchestrates the phenotypic transition of macrophages; however, the precise mechanisms governing metabolic reprogramming of cardiac reparative macrophages remain poorly understood. In this study, we investigated the role of Nucleophosmin 1 (NPM1) in the metabolic and phenotypic shift of cardiac macrophages in the context of MI, and explored the effect of targeting NPM1 for ischemic tissue repair. |
| Institute | Renji Hospital, Shanghai Jiao Tong University School of Medicine |
| Last Name | Zhan |
| First Name | Zhenzhen |
| Address | 160 Pujian Road, Shanghai, Shanghai, 200127, China |
| zhanzz2022@sjtu.edu.cn | |
| Phone | 86-21-61569249 |
| Submit Date | 2023-11-23 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-03-20 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN004909 |
|---|---|
| Analysis type | MS |
| Chromatography type | Ion exchange |
| Chromatography system | Thermo Scientific Dionex ICS-6000 HPIC |
| Column | Dionex IonPac AS11-HC (250 × 2mm, 9um, 2000Ã) and AG11-HC (50 × 2 mm, 13um) |
| MS Type | ESI |
| MS instrument type | QTRAP |
| MS instrument name | ABI Sciex 6500+ |
| Ion Mode | UNSPECIFIED |
| Units | pmol |
Chromatography:
| Chromatography ID: | CH003704 |
| Instrument Name: | Thermo Scientific Dionex ICS-6000 HPIC |
| Column Name: | Dionex IonPac AS11-HC (250 × 2mm, 9um, 2000Ã) and AG11-HC (50 × 2 mm, 13um) |
| Column Temperature: | 30 ℃ |
| Flow Gradient: | 0.15 mL/min: 0min:20%/80%, 3.01min:20%/80%,12min:50%/50%, 21min:100%/100%, 26min:100%/100%, 26.1min:20%/80%,0min:80%/20%, 30min:80%/20% |
| Flow Rate: | 0.15 mL/min |
| Solvent A: | 100 mM NaOH/water; water |
| Solvent B: | water |
| Chromatography Type: | Ion exchange |
| Solvent C: | 2 mM acetic acid in methanol |
