Summary of Study ST000655
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000461. The data can be accessed directly via it's Project DOI: 10.21228/M8G609 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000655 |
Study Title | Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part II) |
Study Summary | In this study we have compared the metabolic effects of conventional soybean oil to those of genetically modified Plenish soybean oil, that is low in linoleic acid and high in oleic acid. This work builds on our previous study showing that soybean oil, rich in polyunsaturated fats, is more obesogenic and diabetogenic than coconut oil, rich in saturated fats (PMID: 26200659). Here, in order to elucidate the mechanisms responsible for soybean oil induced obesity, we have performed the first ever metabolomics (in plasma and liver) and proteomics on the livers of mice fed the two soybean oil diets (plus those fed a high coconut oil and Viv chow diet). Our results show that the new high oleic soybean oil induces less obesity and adiposity than conventional soybean oil, but can cause hepatomegaly and liver dysfunction. Metabolomic analysis reveals that the hepatic and plasma metabolic profiles differ considerably between the two soybean oils. Hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway were found to correlate positively with obesity. |
Institute | University of California, Davis |
Department | Genome and Biomedical Sciences Facility |
Laboratory | WCMC Metabolomics Core |
Last Name | Fiehn |
First Name | Oliver |
Address | 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616 |
ofiehn@ucdavis.edu | |
Phone | (530) 754-8258 |
Submit Date | 2017-06-22 |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2017-07-01 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)
mb_sample_id | local_sample_id | GROUP_DESCRIPTION | TIME_POINT | Genotype |
---|---|---|---|---|
SA037565 | CSH_PM D4-16 e3_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037566 | CSH_PM D4-18 e4_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037567 | CSH_PM D4-16 e1_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037568 | CSH_PM D4-16 e4_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037569 | CSH_PM D4-18 e2_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037570 | CSH_PM D4-18 e3_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037571 | CSH_PM D4-18 e1_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037572 | CSH_PM D4-16 e2_pos_MS_1032014.d | HFD | 24 weeks | WT C57-Bl6 |
SA037573 | CSH_PM a7 D4-4 e4_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037574 | CSH_PM a7 D4-4 e2_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037575 | CSH_PM a7 D4-2 e2_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037576 | CSH_PM a7 D4-2 e1_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037577 | CSH_PM a7 D4-2 e3_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037578 | CSH_PM a7 D4-2 e4_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037579 | CSH_PM a7 D4-4 e1_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037580 | CSH_PM a7 D4-4 e3_pos_MS_1032014.d | HFD | 35 weeks | HMZ a7 |
SA037581 | CSH_PM D4-9 e1_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037582 | CSH_PM D4-11 e3_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037583 | CSH_PM D4-9 e3_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037584 | CSH_PM D4-11 e1_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037585 | CSH_PM D4-10 e3_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037586 | CSH_PM D4-10 e2_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037587 | CSH_PM D4-10 e1_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037588 | CSH_PM D4-9 e2_pos_MS_1032014.d | HFD | 35 weeks | WT C57-Bl6 |
SA037589 | CSH_PM D3-18 e3_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037590 | CSH_PM D3-18 e4_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037591 | CSH_PM D3-18 e2_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037592 | CSH_PM D3-17 e2_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037593 | CSH_PM D3-17 e1_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037594 | CSH_PM D3-18 e1_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037595 | CSH_PM D3-17 e4_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037596 | CSH_PM D3-17 e3_pos_MS_1032014.d | LA-HFD | 24 weeks | WT C57-Bl6 |
SA037597 | CSH_PM a7 D3-4 e4_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037598 | CSH_PM a7 D3-1 e3_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037599 | CSH_PM a7 D3-5 e1_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037600 | CSH_PM a7 D3-4 e2_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037601 | CSH_PM a7 D3-5 e2_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037602 | CSH_PM a7 D3-5 e3_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037603 | CSH_PM a7 D3-5 e5_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037604 | CSH_PM a7 D3-5 e4_pos_MS_1032014.d | LA-HFD | 35 weeks | HMZ a7 |
SA037605 | CSH_PM D3-12 e3_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037606 | CSH_PM D3-13 e3_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037607 | CSH_PM D3-12 e1_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037608 | CSH_PM D3-10 e4_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037609 | CSH_PM D3-10 e1_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037610 | CSH_PM D3-11 e2_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037611 | CSH_PM D3-11 e3_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037612 | CSH_PM D3-11 e1_pos_MS_1032014.d | LA-HFD | 35 weeks | WT C57-Bl6 |
SA037613 | QC002 | N/A | N/A | N/A |
SA037614 | QC003 | N/A | N/A | N/A |
SA037615 | QC001 | N/A | N/A | N/A |
SA037616 | CSH_PM PL-4 e3_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037617 | CSH_PM PL-4 e2_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037618 | CSH_PM PL-4 e4_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037619 | CSH_PM PL-5 e2_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037620 | CSH_PM PL-5 e4_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037621 | CSH_PM PL-4 e1_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037622 | CSH_PM PL-5 e1_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037623 | CSH_PM PL-5 e3_pos_MS_1032014.d | PL-HFD | 24 weeks | WT C57-Bl6 |
SA037624 | CSH_PM 14 e3_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037625 | CSH_PM 14 e2_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037626 | CSH_PM 14 e4_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037627 | CSH_PM 16 e2_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037628 | CSH_PM 10 e1_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037629 | CSH_PM 16 e4_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037630 | CSH_PM 14 e1 _pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037631 | CSH_PM 16 e1_pos_MS_1032014.d | Viv chow | 24 weeks | WT C57-Bl6 |
SA037632 | CSH_PM a7 V-3 e1_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037633 | CSH_PM a7 V-1 e3_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037634 | CSH_PM a7 V-1 e2_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037635 | CSH_PM a7 V-2 e1_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037636 | CSH_PM a7 V-2 e2_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037637 | CSH_PM a7 V-3 e2_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037638 | CSH_PM a7 V-1 e4_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037639 | CSH_PM a7 V-3 e3_pos_MS_1032014.d | Viv chow | 35 weeks | HMZ a7 |
SA037640 | CSH_PM 9 e3_pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
SA037641 | CSH_PM 9 e4_pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
SA037642 | CSH_PM 9 e2_pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
SA037643 | CSH_PM 10 e2_pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
SA037644 | CSH_PM 10 e3_pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
SA037645 | CSH_PM 10 e4_pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
SA037646 | CSH_PM 9 e1 _pos_MS_1032014.d | Viv chow | 35 weeks | WT C57-Bl6 |
Showing results 1 to 82 of 82 |