Summary of Study ST002773

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001730. The data can be accessed directly via it's Project DOI: 10.21228/M8371M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002773
Study TitleA nested case-control study of untargeted plasma metabolomics and lung cancer risk among never-smoking women in Shanghai Women’s Health Study
Study SummaryBackground: The etiology of lung cancer among never smokers has not been fully elucidated despite 15% of cases in men and 53% in women worldwide are not smoking-related. Metabolomics provides a snapshot of dynamic biochemical activities, including those found to be driving tumor formation and progression. This study used untargeted metabolomics with network analysis to agnostically identify network modules and independent metabolites in pre-diagnostic blood samples among never-smokers to further understand the pathogenesis of lung cancer. Methods and Findings: Within the prospective Shanghai Women’s Health Study, we conducted a nested case-control study of 395 never-smoking incident lung cancer cases and 395 never-smoking controls matched on age. We performed liquid chromatography high-resolution mass spectrometry to quantify 20,348 metabolic features in plasma. We agnostically constructed 28 network modules using a weighted correlation network analysis approach and assessed associations for network modules and individual metabolites with lung cancer using conditional logistic regression models, adjusting for covariates. We accounted for multiple testing using a false discovery rate (FDR) < 0.20. We identified a network module of 122 metabolic features enriched in lysophosphatidylethanolamines that was associated with all lung cancer combined (p = 0.001, FDR = 0.028) and lung adenocarcinoma (p = 0.002, FDR = 0.056) and another network module of 440 metabolic features that was associated with lung adenocarcinoma (p = 0.014, FDR = 0.196). Metabolic features were enriched in pathways associated with cell growth and proliferation, including oxidative stress, bile acid biosynthesis, and metabolism of nucleic acids, carbohydrates, and amino acids, including 1-carbon compounds. Conclusions: Our prospective study suggests that untargeted plasma metabolomics in pre-diagnostic samples could provide new insights into the etiology of lung cancer in never-smokers. Replication and further characterization of these associations are warranted.
Institute
Emory University
DepartmentGangarosa Department of Environmental Health
LaboratoryComprehensive Laboratory for Untargeted Exposome Science
Last NameWalker
First NameDouglas
Address1518 Clifton Rd, CNR 7025, Atlanta, GA 30322
Emaildouglas.walker@emory.edu
Phone(404) 727-6123
Submit Date2023-06-19
Num Groups2
Total Subjects790
Num Females790
Study CommentsSamples were collected from participants enrolled in the Shanghai Women's Health Study
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2024-02-28
Release Version1
Douglas Walker Douglas Walker
https://dx.doi.org/10.21228/M8371M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Subject_ID LungCancer
SA294464nist1NIST_1950 NA
SA294465nist2NIST_1950 NA
SA294466q3June2014_11aPooledQAQC NA
SA294467q3June2014_10fPooledQAQC NA
SA294468q3June2014_11bPooledQAQC NA
SA294469q3June2014_11dPooledQAQC NA
SA294470q3June2014_11fPooledQAQC NA
SA294471q3June2014_11ePooledQAQC NA
SA294472q3June2014_10ePooledQAQC NA
SA294473q3June2014_11cPooledQAQC NA
SA294474q3June2014_10dPooledQAQC NA
SA294475q3June2014_9ePooledQAQC NA
SA294476q3June2014_9dPooledQAQC NA
SA294477q3June2014_9fPooledQAQC NA
SA294478q3June2014_10aPooledQAQC NA
SA294479q3June2014_10cPooledQAQC NA
SA294480q3June2014_10bPooledQAQC NA
SA294481q3June2014_12aPooledQAQC NA
SA294482q3June2014_12cPooledQAQC NA
SA294483q3June2014_14aPooledQAQC NA
SA294484q3June2014_13fPooledQAQC NA
SA294485q3June2014_14bPooledQAQC NA
SA294486q3June2014_14cPooledQAQC NA
SA294487q3June2014_14ePooledQAQC NA
SA294488q3June2014_14dPooledQAQC NA
SA294489q3June2014_13ePooledQAQC NA
SA294490q3June2014_13cPooledQAQC NA
SA294491q3June2014_12dPooledQAQC NA
SA294492q3June2014_9cPooledQAQC NA
SA294493q3June2014_12ePooledQAQC NA
SA294494q3June2014_12fPooledQAQC NA
SA294495q3June2014_13bPooledQAQC NA
SA294496q3June2014_13aPooledQAQC NA
SA294497q3June2014_12bPooledQAQC NA
SA294498q3June2014_9aPooledQAQC NA
SA294499q3June2014_5dPooledQAQC NA
SA294500q3June2014_5cPooledQAQC NA
SA294501q3June2014_5bPooledQAQC NA
SA294502q3June2014_5ePooledQAQC NA
SA294503q3June2014_5fPooledQAQC NA
SA294504q3June2014_6bPooledQAQC NA
SA294505q3June2014_6aPooledQAQC NA
SA294506q3June2014_5aPooledQAQC NA
SA294507q3June2014_4fPooledQAQC NA
SA294508q3June2014_4aPooledQAQC NA
SA294509q3June2014_3fPooledQAQC NA
SA294510q3June2014_4bPooledQAQC NA
SA294511q3June2014_4cPooledQAQC NA
SA294512q3June2014_4ePooledQAQC NA
SA294513q3June2014_4dPooledQAQC NA
SA294514q3June2014_6cPooledQAQC NA
SA294515q3June2014_6dPooledQAQC NA
SA294516q3June2014_8cPooledQAQC NA
SA294517q3June2014_8bPooledQAQC NA
SA294518q3June2014_8aPooledQAQC NA
SA294519q3June2014_8dPooledQAQC NA
SA294520q3June2014_8ePooledQAQC NA
SA294521q3June2014_14fPooledQAQC NA
SA294522q3June2014_8fPooledQAQC NA
SA294523q3June2014_7fPooledQAQC NA
SA294524q3June2014_7ePooledQAQC NA
SA294525q3June2014_6fPooledQAQC NA
SA294526q3June2014_6ePooledQAQC NA
SA294527q3June2014_7aPooledQAQC NA
SA294528q3June2014_7bPooledQAQC NA
SA294529q3June2014_7dPooledQAQC NA
SA294530q3June2014_7cPooledQAQC NA
SA294531q3June2014_9bPooledQAQC NA
SA294532q3June2014_15bPooledQAQC NA
SA294533q3June2014_22cPooledQAQC NA
SA294534q3June2014_22bPooledQAQC NA
SA294535q3June2014_22aPooledQAQC NA
SA294536q3June2014_22dPooledQAQC NA
SA294537q3June2014_22ePooledQAQC NA
SA294538q3June2014_23aPooledQAQC NA
SA294539q3June2014_22fPooledQAQC NA
SA294540q3June2014_21fPooledQAQC NA
SA294541q3June2014_21ePooledQAQC NA
SA294542q3June2014_20fPooledQAQC NA
SA294543q3June2014_20ePooledQAQC NA
SA294544q3June2014_21aPooledQAQC NA
SA294545q3June2014_21bPooledQAQC NA
SA294546q3June2014_21dPooledQAQC NA
SA294547q3June2014_21cPooledQAQC NA
SA294548q3June2014_23bPooledQAQC NA
SA294549q3June2014_23cPooledQAQC NA
SA294550q3June2014_25bPooledQAQC NA
SA294551q3June2014_25aPooledQAQC NA
SA294552q3June2014_24fPooledQAQC NA
SA294553q3June2014_25cPooledQAQC NA
SA294554q3June2014_25dPooledQAQC NA
SA294555q3June2014_25fPooledQAQC NA
SA294556q3June2014_25ePooledQAQC NA
SA294557q3June2014_24ePooledQAQC NA
SA294558q3June2014_24dPooledQAQC NA
SA294559q3June2014_23ePooledQAQC NA
SA294560q3June2014_23dPooledQAQC NA
SA294561q3June2014_23fPooledQAQC NA
SA294562q3June2014_24aPooledQAQC NA
SA294563q3June2014_24cPooledQAQC NA
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