Summary of Study ST003132
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001945. The data can be accessed directly via it's Project DOI: 10.21228/M89M7J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003132 |
| Study Title | Untargeted Metabolomics on Mouse colonic mucosa |
| Study Type | Mouse |
| Study Summary | While there is strong evidence for interactions between the microbiota-gut-brain axis and host physiology in the context of chronic stress, limited research has investigated the role of the microbiome in host response to acute stress. Determining the underlying mechanisms by which stress-induced microbiota changes may provoke functional changes in the gut and brain is critical for developing future therapeutics to alleviate the adverse consequences of traumatic stress. Here, we aimed to identify a biological signature of gut metabolites that are significantly altered following exposure to acute restraint stress. Adult male C57Bl/6 conventional, germ-free and colonized germ-free mice underwent a 15-minute restraint stress exposure. Caecal contents were collected from naïve mice and stressed mice, either immediately or 45 minutes following stress. Colonic mucosa underwent untargeted metabolomics analysis. |
| Institute | University College Cork |
| Department | Psychiatry |
| Laboratory | Microbiota-Gut-Brain Axis Group |
| Last Name | Clarke |
| First Name | Gerard |
| Address | Gaol Walk, Cork |
| G.Clarke@ucc.ie | |
| Phone | +353-21-4901408 |
| Submit Date | 2024-03-19 |
| Num Groups | 9 |
| Total Subjects | 63 |
| Num Males | 63 |
| Analysis Type Detail | Other |
| Release Date | 2024-03-22 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001945 |
| Project DOI: | doi: 10.21228/M89M7J |
| Project Title: | The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut |
| Project Type: | Untargeted metabolomics by Metabolon |
| Project Summary: | Adult male C57Bl/6 conventional, germ-free and colonized germ-free mice underwent a 15-minute restraint stress exposure. Caecal contents and colonic mucosal scrapings were collected from naïve mice and stressed mice, either immediately or 45 minutes following stress. Caecal contents and colonic mucosal scrapings underwent untargeted metabolomics analysis. |
| Institute: | University College Cork |
| Department: | Psychiatry |
| Laboratory: | Microbiota-Gut-Brain Axis Group |
| Last Name: | Clarke |
| First Name: | Gerard |
| Address: | Gaol Walk, Cork |
| Email: | G.Clarke@ucc.ie |
| Phone: | +353-21-4901408 |
| Funding Source: | The research was conducted in the APC Microbiome Ireland which is funded by Science Foundation Ireland (SFI/12/RC/2273). This project in part is a collaborative agreement (FA9550-17-1-0016) funded by European Office of Aerospace Research and Development, Air Force Office of Scientific Research and 711 Human Performance Wing, Air Force Research Laboratory. |
