Summary of Study ST003159
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001964. The data can be accessed directly via it's Project DOI: 10.21228/M8VD96 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003159 |
| Study Title | Untargeted serum metabolomics in the Parkinson's Environment and Genes (PEG) Study |
| Study Summary | This project aims to evaluate the serum metabolome of Parkinson’s disease (PD) patients relative to unaffected controls in the Parkinson’s Environment and Genes (PEG) Study. Background: Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways. Objective: Identify metabolic disturbances associated with PD in the PEG population-based study using untargeted metabolomics. Methods: We provide serum-based untargeted metabolomics data derived from liquid chromatography with high-resolution mass spectrometry (LC-HRMS). LC-HRMS detected 4,762 metabolites for analysis (HILIC: 2716 metabolites; C18: 2046 metabolites). |
| Institute | University of California, Los Angeles |
| Department | Neurology |
| Last Name | Paul |
| First Name | Kimberly |
| Address | 710 Westwood Plaza, Los Angeles, CA, 90095, USA |
| kimberlp@ucla.edu | |
| Phone | 310.206.7458 |
| Submit Date | 2023-12-15 |
| Total Subjects | 919 |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-04-23 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001964 |
| Project DOI: | doi: 10.21228/M8VD96 |
| Project Title: | Untargeted serum metabolomics in the Parkinson's Environment and Genes (PEG) Study |
| Project Summary: | This project aims to evaluate the serum metabolome of Parkinson’s disease (PD) patients relative to unaffected controls in the Parkinson’s Environment and Genes (PEG) Study. Background: Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways. Objective: Identify metabolic disturbances associated with PD in the PEG population-based study using untargeted metabolomics. Methods: We provide serum-based untargeted metabolomics data derived from liquid chromatography with high-resolution mass spectrometry (LC-HRMS). LC-HRMS detected 4,762 metabolites for analysis (HILIC: 2716 metabolites; C18: 2046 metabolites). |
| Institute: | University of California Los Angeles |
| Last Name: | Paul |
| First Name: | Kimberly |
| Address: | 710 Westwood Plaza, Los Angeles, CA, 90095, USA |
| Email: | kimberlp@ucla.edu |
| Phone: | 310.206.7458 |
| Funding Source: | National Institute of Environmental Health Sciences |
| Publications: | Paul, K. C., Zhang, K., Walker, D. I., Sinsheimer, J., Yu, Y., Kusters, C., ... & Ritz, B. (2023). Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s disease. Molecular Neurodegeneration, 18(1), 100. |
| Contributors: | Beate Ritz MD PhD, Dean P. Jones PhD, Kimberly C. Paul PhD, Jeff Bronstein PhD MD |
