Summary of Study ST003040
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001892. The data can be accessed directly via it's Project DOI: 10.21228/M8572M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST003040 |
Study Title | MM.1S Myeloma tumor cells and tumors made by subcutaneously injecting 1M Luc+/GFP+ MM.1S cells treated with 50 μM BMS309403 and Vehicle (PBS with a matched concentration of 5% DMSO) |
Study Summary | MM.1S Myeloma tumor cells were treated with 50 μM BMS309403 once over 24 hours in vitro or at 5mg/kg X3 per week over 32 days in vivo. In Vivo tumors were made by subcutaneously injecting 1M Luc+/GFP+ MM.1S cells mixed with Matrigel in a 1:1 ratio into the backs of 8-week old, female SCID-Beige. Vehicle (PBS with a matched concentration of 5% DMSO) was used as control for each condition. |
Institute | Mainehealth |
Last Name | Reagan |
First Name | Michaela |
Address | 81 Research Drive, Scarborough, ME, Portland, ME, 04074, USA |
Michaela.Reagan@mainehealth.org | |
Phone | (207)396-8196 |
Submit Date | 2023-12-20 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2024-03-25 |
Release Version | 1 |
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Sample Preparation:
Sampleprep ID: | SP003160 |
Sampleprep Summary: | Lipids were extracted from cell and tumors previously treated with Vehicle and BMS309403 using a modified Bligh and Dyer protocol [Bligh and Dyer, 1959] of Avanti Polar Lipids, INC. Water:Methanol:Dichloromethane (34:34:31, v/v/v). After the extraction and dried out the samples were resuspended in Methanol:Dichloromethane (50:50, v/v) with 10 mM of Ammonium acetate to be injected by Direct Infusion. |